MCID: PRC017
MIFTS: 26

Precursor Lymphoblastic Lymphoma/leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Precursor Lymphoblastic Lymphoma/leukemia

MalaCards integrated aliases for Precursor Lymphoblastic Lymphoma/leukemia:

Name: Precursor Lymphoblastic Lymphoma/leukemia 12 15
Precursor Cell Lymphoblastic Leukemia Lymphoma 73
Precursor Lymphoid Neoplasm 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5600
NCIt 50 C7055

Summaries for Precursor Lymphoblastic Lymphoma/leukemia

Disease Ontology : 12 A lymphoblastic leukemia that has material basis in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located in bone marrow and located in peripheral blood.

MalaCards based summary : Precursor Lymphoblastic Lymphoma/leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to precursor t-lymphoblastic lymphoma/leukemia and precursor b lymphoblastic lymphoma/leukemia. An important gene associated with Precursor Lymphoblastic Lymphoma/leukemia is PTPRJ (Protein Tyrosine Phosphatase, Receptor Type J), and among its related pathways/superpathways are Innate Immune System and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Vincristine and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and b cells.

Related Diseases for Precursor Lymphoblastic Lymphoma/leukemia

Diseases in the Precursor Lymphoblastic Lymphoma/leukemia family:

Precursor B Lymphoblastic Lymphoma/leukemia Precursor T-Lymphoblastic Lymphoma/leukemia

Diseases related to Precursor Lymphoblastic Lymphoma/leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 precursor t-lymphoblastic lymphoma/leukemia 9.9 IRF6 MME
2 precursor b lymphoblastic lymphoma/leukemia 9.8 CD27 PTPRJ
3 follicular lymphoma 9.8 CD27 MME
4 myeloma, multiple 9.8 CD27 MME
5 lymphoma, non-hodgkin, familial 9.7 CD27 MME

Graphical network of the top 20 diseases related to Precursor Lymphoblastic Lymphoma/leukemia:



Diseases related to Precursor Lymphoblastic Lymphoma/leukemia

Symptoms & Phenotypes for Precursor Lymphoblastic Lymphoma/leukemia

Drugs & Therapeutics for Precursor Lymphoblastic Lymphoma/leukemia

Drugs for Precursor Lymphoblastic Lymphoma/leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
2
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
3
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
4
Daunorubicin Approved Phase 2 20830-81-3 30323
5
Pegaspargase Approved, Investigational Phase 2 130167-69-0
6
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
7
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
8
Etoposide Approved Phase 2 33419-42-0 36462
9 Imatinib Mesylate Phase 2 220127-57-1 123596
10 6-Mercaptopurine Phase 2
11 Etoposide phosphate Phase 2
12
asparaginase Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Personalized Therapy of Precursor Lymphoid Neoplasms Unknown status NCT01665001 Phase 2

Search NIH Clinical Center for Precursor Lymphoblastic Lymphoma/leukemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Precursor Lymphoblastic Lymphoma/leukemia

Anatomical Context for Precursor Lymphoblastic Lymphoma/leukemia

MalaCards organs/tissues related to Precursor Lymphoblastic Lymphoma/leukemia:

41
Bone, T Cells, B Cells, Bone Marrow, B Lymphoblasts

Publications for Precursor Lymphoblastic Lymphoma/leukemia

Variations for Precursor Lymphoblastic Lymphoma/leukemia

Expression for Precursor Lymphoblastic Lymphoma/leukemia

Search GEO for disease gene expression data for Precursor Lymphoblastic Lymphoma/leukemia.

Pathways for Precursor Lymphoblastic Lymphoma/leukemia

Pathways related to Precursor Lymphoblastic Lymphoma/leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 CD27 IRF6 MME PTPRJ
2 10.82 IRF6 MME
3 10.35 CD27 MME

GO Terms for Precursor Lymphoblastic Lymphoma/leukemia

Cellular components related to Precursor Lymphoblastic Lymphoma/leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.8 CD27 MME PTPRJ

Sources for Precursor Lymphoblastic Lymphoma/leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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