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MCID: PRC049
MIFTS: 38

Precursor T-Cell Acute Lymphoblastic Leukemia

Categories: Blood diseases, Rare diseases, Immune diseases, Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards integrated aliases for Precursor T-Cell Acute Lymphoblastic Leukemia:

Name: Precursor T-Cell Acute Lymphoblastic Leukemia 59
T-All 59 55
Precursor T-Cell Acute Lymphoblastic Leukemia/lymphoma 59
Precursor T-Cell Acute Lymphocytic Leukemia/lymphoma 59
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 73
Precursor T-Cell Acute Lymphocytic Leukemia 59
Adult T-Cell Lymphoma/leukemia 73

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare haematological diseases


External Ids:

Orphanet 59 ORPHA99861
ICD10 via Orphanet 34 C91.0
UMLS via Orphanet 74 C1961099
UMLS 73 C1961099
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Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards based summary : Precursor T-Cell Acute Lymphoblastic Leukemia, also known as t-all, is related to acute t cell leukemia and leukemia, acute lymphoblastic. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is BAX (BCL2 Associated X, Apoptosis Regulator), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include t cells, bone marrow and bone, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

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Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 acute t cell leukemia 32.4 BAX BCL10 TRB
2 leukemia, acute lymphoblastic 32.1 ABL1 BCR FLT3 PICALM TRD
3 lymphoblastic leukemia 31.9 ABL1 BAX BCR CDKN2A FLT3 TLX1
4 lymphoma 31.6 BAX BCL10 MYC TCL1A
5 leukemia 31.5 ABL1 BAX BCR FLT3 TAL1 TCL1A
6 myeloid leukemia 31.0 ABL1 BCR FLT3 PICALM
7 leukemia, acute myeloid 30.6 ABL1 BCR FLT3 MLLT10 MYB MYC
8 suppressor of tumorigenicity 3 11.0 BAX CDKN2A MYC
9 neonatal leukemia 11.0 FLT3 MLLT10 MYC
10 philadelphia-negative chronic myeloid leukemia 10.9 ABL1 BCR
11 acute lymphocytic leukemia 10.9 BCR CDKN2A TAL1 TLX3
12 leukemia, acute lymphoblastic 3 10.9 ABL1 BCR CDKN2A FLT3
13 b-cell lymphomas 10.8 BAX BCL10 CDKN2A MYC TCL1A
14 t-cell prolymphocytic leukemia 10.8 ABL1 MYC TCL1A
15 lymphoma, non-hodgkin, familial 10.8 BAX BCL10 BCR MYC TCL1A
16 t-cell leukemia 10.8 MYC TAL1 TCL1A TLX1 TLX3
17 subcutaneous panniculitis-like t-cell lymphoma 10.7 MYC TRD
18 leukemia, chronic myeloid 10.7 ABL1 BCR FLT3 MYB MYC
19 burkitt lymphoma 10.7 BAX BCR MYC TCL1A
20 hematologic cancer 10.7 ABL1 BCR FLT3 MLLT10 MYC PICALM
21 thyroid lymphoma 10.6 CDKN2A PICALM
22 acute promyelocytic leukemia 10.6 BAX FLT3 MYC ZBTB16
23 acute leukemia 10.3 FLT3 MLLT10 TAL1
24 lymphoblastic lymphoma 10.1
25 laryngitis 10.1
26 acute pancreatitis 10.0
27 thymoma 10.0
28 retinitis 10.0
29 pancreatitis 10.0
30 retinal detachment 10.0
31 bone marrow necrosis 10.0
32 aging 10.0
33 acute biphenotypic leukemia 10.0

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia
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Symptoms & Phenotypes for Precursor T-Cell Acute Lymphoblastic Leukemia

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MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.24 BCR PICALM CDKN2A STIL TAL1 FLT3
2 hematopoietic system MP:0005397 10.03 BCR PICALM CDKN2A FLT3 ABL1 MYB
3 embryo MP:0005380 10.02 PICALM CDKN2A STIL TAL1 ABL1 MYB
4 immune system MP:0005387 9.97 BCR PICALM CDKN2A TAL1 FLT3 ABL1
5 mortality/aging MP:0010768 9.77 NUP214 BCR PICALM CDKN2A STIL FLT3
6 neoplasm MP:0002006 9.1 CDKN2A FLT3 BAX MYC TLX3 ZBTB16
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Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

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Search Clinical Trials , NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

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Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

41
T Cells, Bone Marrow, Bone, Appendix, Cervix, Myeloid
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Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

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Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

(show all 17)
# Title Authors Year
1
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. ( 25624896 )
2015
2
A 25-Year-Old Man with Exudative Retinal Detachments and Infiltrates without Hematological or Neurological Findings Found to Have Relapsed Precursor T-Cell Acute Lymphoblastic Leukemia. ( 26483676 )
2015
3
Secondary pancreatic involvement by precursor T-cell acute lymphoblastic leukemia presenting as acute pancreatitis. ( 26905170 )
2015
4
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia. ( 23349303 )
2013
5
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. ( 23057758 )
2012
6
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder. ( 22184539 )
2011
7
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. ( 18722237 )
2008
8
Gum hypertrophy - an unusual presenting feature in a case of precursor T-cell acute lymphoblastic leukemia. ( 27264925 )
2008
9
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. ( 17369128 )
2007
10
A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. ( 17498558 )
2007
11
Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. ( 16493618 )
2006
12
An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma. ( 15843931 )
2005
13
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. ( 14983942 )
2004
14
ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblastic leukemia/lymphoma: report of the first case. ( 15282669 )
2004
15
Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix. ( 12004362 )
2002
16
Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets. ( 11863221 )
2002
17
Orbital mass secondary to precursor T-cell acute lymphoblastic leukemia: a rare presentation. ( 11231781 )
2001
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Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

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ClinVar genetic disease variations for Precursor T-Cell Acute Lymphoblastic Leukemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.136_137insA (p.Ile46Asnfs) insertion Pathogenic rs387906351 GRCh37 Chromosome 1, 85736511: 85736511
2 BCL10 NM_003921.4(BCL10): c.136_137insA (p.Ile46Asnfs) insertion Pathogenic rs387906351 GRCh38 Chromosome 1, 85270828: 85270828
3 BAX NM_138761.3(BAX): c.199G> A (p.Gly67Arg) single nucleotide variant Pathogenic rs398122513 GRCh37 Chromosome 19, 49459056: 49459056
4 BAX NM_138761.3(BAX): c.199G> A (p.Gly67Arg) single nucleotide variant Pathogenic rs398122513 GRCh38 Chromosome 19, 48955799: 48955799
5 BAX NM_138761.3(BAX): c.115_121delGGGGGGG (p.Gly39Argfs) deletion Pathogenic rs398122842 GRCh37 Chromosome 19, 49458972: 49458978
6 BAX NM_138761.3(BAX): c.115_121delGGGGGGG (p.Gly39Argfs) deletion Pathogenic rs398122842 GRCh38 Chromosome 19, 48955715: 48955721
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Expression for Precursor T-Cell Acute Lymphoblastic Leukemia

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Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.
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Pathways for Precursor T-Cell Acute Lymphoblastic Leukemia

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Pathways related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.55 ABL1 BAX BCR CDKN2A FLT3 MYC
2
Pathways in cancer 37
12.42 ABL1 BAX BCR CDKN2A FLT3 MYC
3
NF-kappaB Signaling 4
12.29 BCL10 MYB TAL1 ZBTB16
4
HTLV-I infection 37
12.14 BAX CDKN2A MYB MYC
5
DNA Damage Response 1
Show member pathways
 12.07 ABL1 BAX CDKN2A MYC
6
Immune response Antigen presentation by MHC class II 22
Show member pathways
 11.87 MYC TRA TRB
7
DNA Damage Response (only ATM dependent) 1
11.73 ABL1 BAX CDKN2A MYC
8
Transcriptional misregulation in cancer 37
11.7 BAX FLT3 MYC TLX1 TLX3 ZBTB16
9
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.84 ABL1 CDKN2A MYC
10
TP53 Network 1
Show member pathways
 10.27 ABL1 BAX CDKN2A MYC
Sources

GO Terms for Precursor T-Cell Acute Lymphoblastic Leukemia

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Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.93 ABL1 BAX BCL10 BCR CDKN2A FLT3
2 nucleus GO:0005634 9.83 ABL1 BAX BCL10 CDKN2A FLT3 MLLT10
3 protein-containing complex GO:0032991 9.28 ABL1 BCL10 BCR FLT3 MLLT10 MYC

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.87 ABL1 BAX BCL10 FLT3
2 positive regulation of apoptotic process GO:0043065 9.72 ABL1 BAX BCL10 CDKN2A ZBTB16
3 regulation of hematopoietic stem cell differentiation GO:1902036 9.7 ABL1 MYB TAL1
4 neural tube closure GO:0001843 9.65 ABL1 BCL10 STIL
5 regulation of cell cycle GO:0051726 9.56 ABL1 BAX BCR NUP214
6 definitive hemopoiesis GO:0060216 9.55 BCR TAL1
7 positive regulation of protein oligomerization GO:0032461 9.54 BAX TCL1A
8 hypothalamus development GO:0021854 9.51 BAX MYC
9 positive regulation of glial cell proliferation GO:0060252 9.49 MYB MYC
10 positive regulation of mitochondrial membrane potential GO:0010918 9.46 MYC TCL1A
11 negative regulation of ubiquitin-protein transferase activity GO:0051444 9.43 ABL1 CDKN2A
12 B cell apoptotic process GO:0001783 9.4 BAX BCL10
13 leukocyte homeostasis GO:0001776 9.37 BAX FLT3
14 positive regulation of neuron death GO:1901216 9.33 ABL1 MYB PICALM
15 hemopoiesis GO:0030097 9.26 FLT3 PICALM TAL1 ZBTB16
16 positive regulation of transcription, DNA-templated GO:0045893 9.17 BCL10 CDKN2A MYB MYC PICALM TAL1
17 regulation of transcription, DNA-templated GO:0006355 10.21 ABL1 CDKN2A MLLT10 MYB MYC TAL1

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ABL1 BAX BCL10 BCR CDKN2A FLT3
2 DNA binding GO:0003677 9.28 ABL1 CDKN2A MLLT10 MYB MYC TAL1
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Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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