T-ALL
MCID: PRC049
MIFTS: 49

Precursor T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards integrated aliases for Precursor T-Cell Acute Lymphoblastic Leukemia:

Name: Precursor T-Cell Acute Lymphoblastic Leukemia 59
T-All 59 55
Precursor T-Cell Acute Lymphoblastic Leukemia/lymphoma 59
Precursor T-Cell Acute Lymphocytic Leukemia/lymphoma 59
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 73
Precursor T-Cell Acute Lymphocytic Leukemia 59
Adult T-Cell Lymphoma/leukemia 73

Classifications:



External Ids:

Orphanet 59 ORPHA99861
ICD10 via Orphanet 34 C91.0
UMLS via Orphanet 74 C1961099

Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards based summary : Precursor T-Cell Acute Lymphoblastic Leukemia, also known as t-all, is related to leukemia, acute lymphoblastic and acute t cell leukemia. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is BAX (BCL2 Associated X, Apoptosis Regulator), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include t cells, bone and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 31.4 ABL1 BCR FLT3 PICALM TRD
2 acute t cell leukemia 31.4 BAX BCL10 MLLT10 NUP214 TAL1 TLX1
3 leukemia 31.3 ABL1 BAX BCR FLT3 TAL1 TLX1
4 myeloid leukemia 30.4 ABL1 BCR FLT3 PICALM
5 leukemia, acute myeloid 30.3 ABL1 BCR FLT3 MLLT10 MYB MYC
6 acute lymphocytic leukemia 30.2 BCR CDKN2A TAL1 TLX3
7 t-cell leukemia 30.1 CDKN2A MYB MYC TAL1 TLX1 TLX3
8 acute leukemia 29.9 FLT3 MLLT10 TAL1
9 lymphoma, non-hodgkin, familial 29.7 BAX BCL10 BCR MYC
10 lymphocytic leukemia 10.7
11 lymphoma 10.5
12 philadelphia-negative chronic myeloid leukemia 10.3 ABL1 BCR
13 suppressor of tumorigenicity 3 10.3 BAX CDKN2A MYC
14 neonatal leukemia 10.3 FLT3 MLLT10 MYC
15 lymphoblastic lymphoma 10.3
16 leukemia, acute lymphoblastic 3 10.2 ABL1 BCR CDKN2A FLT3
17 b-cell lymphomas 10.2 BAX BCL10 CDKN2A MYC
18 leukemia, chronic myeloid 10.2 ABL1 BCR FLT3 MYB MYC
19 subcutaneous panniculitis-like t-cell lymphoma 10.2 MYC TRD
20 hematologic cancer 10.2 ABL1 BAX BCR FLT3 MLLT10 MYC
21 acute pancreatitis 10.1
22 thymoma 10.1
23 pancreatitis 10.1
24 bone marrow necrosis 10.1
25 sarcoma 9.8
26 burkitt lymphoma 9.6
27 anemia, autoimmune hemolytic 9.6
28 ataxia-telangiectasia 9.6
29 fanconi anemia, complementation group a 9.6
30 galactorrhea 9.6
31 lymphoma, hodgkin, classic 9.6
32 langerhans cell histiocytosis 9.6
33 wilms tumor 6 9.6
34 follicular lymphoma 9.6
35 hemolytic anemia 9.6
36 prolymphocytic leukemia 9.6
37 pancytopenia 9.6
38 papilledema 9.6
39 myeloproliferative neoplasm 9.6
40 histiocytosis 9.6
41 myeloid sarcoma 9.6
42 cleft lip 9.6
43 acute leukemia of ambiguous lineage 9.6
44 histiocytic sarcoma 9.6
45 t-cell prolymphocytic leukemia 9.6

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia

Symptoms & Phenotypes for Precursor T-Cell Acute Lymphoblastic Leukemia

GenomeRNAi Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

26 (show all 33)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.94 BCR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.94 FLT3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.94 TAL1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.94 BCR FLT3 SET TAL1 TLX1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.94 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.94 FLT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.94 BCR FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.94 FLT3 SET
9 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.94 BCR SET
10 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.94 SET
11 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.94 SET
12 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.94 SET TLX1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.94 TAL1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.94 FLT3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.94 BCR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.94 BCR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.94 TAL1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.94 TLX1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.94 BCR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.94 SET
21 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.94 BCR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.94 FLT3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.94 BCR
24 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.94 TAL1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.94 TLX1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.94 TAL1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.94 TAL1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.94 FLT3
29 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.94 TAL1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.94 BCR
31 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.94 BCR
32 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.94 TAL1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.94 TLX1

MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ABL1 BAX BCL10 BCR CDKN2A FLT3
2 embryo MP:0005380 10.02 ABL1 BCL10 CDKN2A MYB MYC NUP214
3 hematopoietic system MP:0005397 10 ABL1 BAX BCL10 BCR CDKN2A FLT3
4 immune system MP:0005387 9.93 ABL1 BAX BCL10 BCR CDKN2A FLT3
5 mortality/aging MP:0010768 9.77 ABL1 BAX BCL10 BCR CDKN2A FLT3
6 nervous system MP:0003631 9.32 ABL1 BAX BCL10 BCR CDKN2A MYC

Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

Search Clinical Trials , NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

41
T Cells, Bone, Prostate, Bone Marrow, Liver, Myeloid, Colon

Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

(show top 50) (show all 216)
# Title Authors Year
1
Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations. ( 30117174 )
2018
2
NOTCH1 pathway activating mutations and clonal evolution in pediatric T-cell acute lymphoblastic leukemia (T-ALL). ( 30387229 )
2018
3
T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1. ( 30412053 )
2018
4
T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies. ( 28830639 )
2018
5
Matrine induced G0/G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia (T-ALL) cells. ( 29045804 )
2018
6
IGF1 Brings Growing Pains for T-ALL LSCs. ( 30388418 )
2018
7
Correlation of expression of aberrant immunophenotypic markers in T-ALL with its morphology: A pilot study. ( 30498313 )
2018
8
Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells. ( 28641473 )
2018
9
Drugging DNA repair to target T-ALL cells. ( 29115896 )
2018
10
Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system. ( 29151585 )
2018
11
Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL. ( 29187379 )
2018
12
Case report: Exome sequencing identifies T-ALL with myeloid features as a IKZF1-struck early precursor T-cell malignancy. ( 29204341 )
2018
13
MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-ALL. ( 29330145 )
2018
14
Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome. ( 29330284 )
2018
15
Refining genetic stratification in T-ALL. ( 29348308 )
2018
16
MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47. ( 29368647 )
2018
17
Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5. ( 29496689 )
2018
18
"Dar"-ing to target CD38 in T-ALL. ( 29496700 )
2018
19
AKR1C enzymes sustain therapy resistance in paediatric T-ALL. ( 29515258 )
2018
20
Saracatinib impairs maintenance of human T-ALL by targeting the LCK tyrosine kinase in cells displaying high level of lipid rafts. ( 29535432 )
2018
21
Investigation of BAX and BCL2 expression and apoptosis in a resveratrol- and prednisolone-treated human T-ALL cell line, CCRF-CEM. ( 29662863 )
2018
22
Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset. ( 29746601 )
2018
23
High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL. ( 29746793 )
2018
24
The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL. ( 29930300 )
2018
25
Expression of CD56 defines a distinct subgroup in childhood T-ALL with inferior outcome. Results of the ALL-BFM 2000 trial. ( 30028023 )
2018
26
Selective killing of human T-ALL cells: an integrated approach targeting redox homeostasis and the OMA1/OPA1 axis. ( 30069011 )
2018
27
NOTCH1 Signaling Hijacks the Stress Response to Promote T-ALL. ( 30076148 )
2018
28
Apoptotic effect of resveratrol on human T-ALL cell line CCRF-CEM is unlikely exerted through alteration of BAX and BCL2 promoter methylation. ( 30132966 )
2018
29
Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL. ( 30159143 )
2018
30
NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263. ( 30224339 )
2018
31
MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells. ( 30297804 )
2018
32
Successful second allogeneic stem cell transplantation in a patient with T-lymphoblastic leukemia (T-ALL) relapsed as myeloid sarcoma. ( 28451803 )
2017
33
DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma. ( 29100357 )
2017
34
The effect of the JAK2 inhibitor TG101209 against T cell acute lymphoblastic leukemia (T-ALL) is mediated by inhibition of JAK-STAT signaling and activation of the crosstalk between apoptosis and autophagy signaling. ( 29290986 )
2017
35
CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. ( 27698445 )
2017
36
T-ALL: several homes rather than homeless? ( 27824040 )
2017
37
The genetics and molecular biology of T-ALL. ( 28115373 )
2017
38
Synergistic antileukemic therapies in NOTCH1-induced T-ALL. ( 28174276 )
2017
39
Targeted therapies for T-cell acute lymphoblastic leukaemia (T-ALL): what makes T-ALL TYK? ( 28211568 )
2017
40
Regarding the sudden death of a juvenile with rare TdT-negative T-LBL/T-ALL, splenic rupture, and mediastinal mass. ( 28215035 )
2017
41
Dnmt3a regulates T-cell development and suppresses T-ALL transformation. ( 28321121 )
2017
42
Response to "regarding the sudden death of a juvenile with rare TdT-negative T-LBL/T-ALL, splenic rupture, and mediastinal mass". ( 28405884 )
2017
43
A TCR-switchable cell death pathway in T-ALL. ( 28540327 )
2017
44
MRD response in a refractory paediatric T-ALL patient through anti-programmed cell death 1 (PD-1) Ab treatment associated with induction of fatal GvHD. ( 28581460 )
2017
45
Creation of a human T-ALL cell line online database. ( 28609209 )
2017
46
Novel oncogenic noncoding mutations in T-ALL. ( 28620102 )
2017
47
Outcome and Clinical Significance of Immunophenotypic Markers Expressed in Different Treatment Protocols of Pediatric Patients With T-ALL in Developing Countries. ( 28624542 )
2017
48
Pediatric T-ALL complicated by irreversible nelarabine neurotoxicity. ( 28745456 )
2017
49
In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL. ( 28885610 )
2017
50
Nelarabine toxicity in children and adolescents with relapsed/refractory T-ALL/T-LBL: can we avoid throwing the baby out with the bathwater? ( 28891074 )
2017

Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

ClinVar genetic disease variations for Precursor T-Cell Acute Lymphoblastic Leukemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.136_137insA (p.Ile46Asnfs) insertion Pathogenic rs387906351 GRCh37 Chromosome 1, 85736511: 85736511
2 BCL10 NM_003921.4(BCL10): c.136_137insA (p.Ile46Asnfs) insertion Pathogenic rs387906351 GRCh38 Chromosome 1, 85270828: 85270828
3 BAX NM_138761.3(BAX): c.199G> A (p.Gly67Arg) single nucleotide variant Pathogenic rs398122513 GRCh37 Chromosome 19, 49459056: 49459056
4 BAX NM_138761.3(BAX): c.199G> A (p.Gly67Arg) single nucleotide variant Pathogenic rs398122513 GRCh38 Chromosome 19, 48955799: 48955799
5 BAX NM_138761.3(BAX): c.115_121delGGGGGGG (p.Gly39Argfs) deletion Pathogenic rs398122842 GRCh37 Chromosome 19, 49458972: 49458978
6 BAX NM_138761.3(BAX): c.115_121delGGGGGGG (p.Gly39Argfs) deletion Pathogenic rs398122842 GRCh38 Chromosome 19, 48955715: 48955721

Expression for Precursor T-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.

Pathways for Precursor T-Cell Acute Lymphoblastic Leukemia

GO Terms for Precursor T-Cell Acute Lymphoblastic Leukemia

Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.85 ABL1 CDKN2A HNRNPH1 MLLT10 MYB MYC
2 nucleus GO:0005634 9.83 ABL1 BAX BCL10 CDKN2A FLT3 HNRNPH1
3 protein-containing complex GO:0032991 9.23 ABL1 BCL10 BCR FLT3 MLLT10 MYC
4 cytosol GO:0005829 10.03 ABL1 BAX BCL10 BCR CDKN2A FLT3

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.73 BCL10 CDKN2A MYB MYC PICALM TAL1
2 neural tube closure GO:0001843 9.63 ABL1 BCL10 STIL
3 hemopoiesis GO:0030097 9.61 FLT3 PICALM TAL1
4 positive regulation of glial cell proliferation GO:0060252 9.51 MYB MYC
5 definitive hemopoiesis GO:0060216 9.49 BCR TAL1
6 hypothalamus development GO:0021854 9.48 BAX MYC
7 regulation of cell cycle GO:0051726 9.46 ABL1 BAX BCR NUP214
8 negative regulation of ubiquitin-protein transferase activity GO:0051444 9.4 ABL1 CDKN2A
9 B cell apoptotic process GO:0001783 9.37 BAX BCL10
10 leukocyte homeostasis GO:0001776 9.32 BAX FLT3
11 positive regulation of neuron death GO:1901216 9.13 ABL1 MYB PICALM
12 regulation of hematopoietic stem cell differentiation GO:1902036 8.8 ABL1 MYB TAL1

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.61 ABL1 CDKN2A MLLT10 MYB MYC SET
2 protein binding GO:0005515 9.55 ABL1 BAX BCL10 BCR CDKN2A FLT3

Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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