MCID: PRC018
MIFTS: 19

Precursor T-Lymphoblastic Lymphoma/leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards integrated aliases for Precursor T-Lymphoblastic Lymphoma/leukemia:

Name: Precursor T-Lymphoblastic Lymphoma/leukemia 12 15
Precursor T Cell Lymphoblastic Leukemia/lymphoblastic Lymphoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5599
UMLS 74 C1301359

Summaries for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards based summary : Precursor T-Lymphoblastic Lymphoma/leukemia, also known as precursor t cell lymphoblastic leukemia/lymphoblastic lymphoma, is related to childhood precursor t-lymphoblastic lymphoma/leukemia and precursor t-lymphoblastic lymphoma/leukemia refractory. An important gene associated with Precursor T-Lymphoblastic Lymphoma/leukemia is IRF6 (Interferon Regulatory Factor 6), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Dexamethasone acetate and Diphenhydramine have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Related Diseases for Precursor T-Lymphoblastic Lymphoma/leukemia

Diseases in the Precursor Lymphoblastic Lymphoma/leukemia family:

Precursor B Lymphoblastic Lymphoma/leukemia Precursor T-Lymphoblastic Lymphoma/leukemia

Diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 childhood precursor t-lymphoblastic lymphoma/leukemia 12.7
2 precursor t-lymphoblastic lymphoma/leukemia refractory 12.7
3 leukemia 10.4
4 lymphoblastic lymphoma 10.4
5 lymphoma 10.4
6 precursor lymphoblastic lymphoma/leukemia 9.5 IRF6 MME

Graphical network of the top 20 diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia:



Diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia

Symptoms & Phenotypes for Precursor T-Lymphoblastic Lymphoma/leukemia

Drugs & Therapeutics for Precursor T-Lymphoblastic Lymphoma/leukemia

Drugs for Precursor T-Lymphoblastic Lymphoma/leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
2
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
3
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
4
Sodium Citrate Approved, Investigational Phase 2 68-04-2
5
Acetaminophen Approved Phase 2 103-90-2 1983
6
Promethazine Approved, Investigational Phase 2 60-87-7 4927
7
Histamine Approved, Investigational Phase 2 51-45-6 774
8
Ranitidine Approved Phase 2 66357-59-3, 66357-35-5 3001055
9 Daratumumab Approved Phase 2 945721-28-8
10
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
11 Antacids Phase 2
12 Gastrointestinal Agents Phase 2
13 HIV Protease Inhibitors Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
15 Autonomic Agents Phase 2
16 Anti-Allergic Agents Phase 2
17 Neurotransmitter Agents Phase 2
18 Antineoplastic Agents, Hormonal Phase 2
19 Peripheral Nervous System Agents Phase 2
20 Bismuth tripotassium dicitrate Phase 2
21 Central Nervous System Depressants Phase 2
22 BB 1101 Phase 2
23 glucocorticoids Phase 2
24 Antipruritics Phase 2
25 Analgesics, Non-Narcotic Phase 2
26 Antipyretics Phase 2
27 Antibodies Phase 2
28 Pharmaceutical Solutions Phase 2
29 Hormones Phase 2
30 Ranitidine bismuth citrate Phase 2
31 Anti-Inflammatory Agents Phase 2
32 Histamine Antagonists Phase 2
33
protease inhibitors Phase 2
34 Dermatologic Agents Phase 2
35 Anesthetics Phase 2
36 Citrate Phase 2
37 Hypnotics and Sedatives Phase 2
38
Bismuth Phase 2 7440-69-9 16682734 105143
39 Antiemetics Phase 2
40 Immunoglobulins Phase 2
41 Analgesics Phase 2
42 Anti-Ulcer Agents Phase 2
43
Histamine Phosphate Phase 2 51-74-1 65513
44 Histamine H1 Antagonists Phase 2
45 Histamine H2 Antagonists Phase 2
46 Antibodies, Monoclonal Phase 2
47 Hormone Antagonists Phase 2
48 Anesthetics, Local Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Isatuximab in Lymphoblastic Leukemia Terminated NCT02999633 Phase 2 Isatuximab SAR650984;dexamethasone;dexamethasone;acetaminophen;ranitidine;diphenhydramine

Search NIH Clinical Center for Precursor T-Lymphoblastic Lymphoma/leukemia

Genetic Tests for Precursor T-Lymphoblastic Lymphoma/leukemia

Anatomical Context for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards organs/tissues related to Precursor T-Lymphoblastic Lymphoma/leukemia:

42
T Cells

Publications for Precursor T-Lymphoblastic Lymphoma/leukemia

Articles related to Precursor T-Lymphoblastic Lymphoma/leukemia:

# Title Authors Year
1
Flow cytometry in the diagnosis of mediastinal tumors with emphasis on differentiating thymocytes from precursor T-lymphoblastic lymphoma/leukemia. ( 15160915 )
2004
2
Translocation (5;17)(q13;q21) in a case with precursor T-lymphoblastic lymphoma/leukemia. ( 11801318 )
2002
3
Immunoperoxidase detection of CD10 in Precursor T-lymphoblastic lymphoma/leukemia: a clinicopathologic study of 24 cases. ( 10782151 )
2000

Variations for Precursor T-Lymphoblastic Lymphoma/leukemia

Expression for Precursor T-Lymphoblastic Lymphoma/leukemia

Search GEO for disease gene expression data for Precursor T-Lymphoblastic Lymphoma/leukemia.

Pathways for Precursor T-Lymphoblastic Lymphoma/leukemia

Pathways related to Precursor T-Lymphoblastic Lymphoma/leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 IRF6 MME

GO Terms for Precursor T-Lymphoblastic Lymphoma/leukemia

Sources for Precursor T-Lymphoblastic Lymphoma/leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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