MCID: PRC018
MIFTS: 14

Precursor T-Lymphoblastic Lymphoma/leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards integrated aliases for Precursor T-Lymphoblastic Lymphoma/leukemia:

Name: Precursor T-Lymphoblastic Lymphoma/leukemia 12 15
Precursor T Cell Lymphoblastic Leukemia/lymphoblastic Lymphoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5599
UMLS 73 C1301359

Summaries for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards based summary : Precursor T-Lymphoblastic Lymphoma/leukemia, also known as precursor t cell lymphoblastic leukemia/lymphoblastic lymphoma, is related to childhood precursor t-lymphoblastic lymphoma/leukemia and precursor t-lymphoblastic lymphoma/leukemia refractory. An important gene associated with Precursor T-Lymphoblastic Lymphoma/leukemia is IRF6 (Interferon Regulatory Factor 6), and among its related pathways/superpathways is Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Diphenhydramine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Related Diseases for Precursor T-Lymphoblastic Lymphoma/leukemia

Diseases in the Precursor Lymphoblastic Lymphoma/leukemia family:

Precursor B Lymphoblastic Lymphoma/leukemia Precursor T-Lymphoblastic Lymphoma/leukemia

Diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 childhood precursor t-lymphoblastic lymphoma/leukemia 12.7
2 precursor t-lymphoblastic lymphoma/leukemia refractory 12.7
3 lymphoblastic lymphoma 10.4
4 lymphoma 10.4
5 leukemia 10.3
6 precursor lymphoblastic lymphoma/leukemia 9.7 IRF6 MME

Graphical network of the top 20 diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia:



Diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia

Symptoms & Phenotypes for Precursor T-Lymphoblastic Lymphoma/leukemia

Drugs & Therapeutics for Precursor T-Lymphoblastic Lymphoma/leukemia

Drugs for Precursor T-Lymphoblastic Lymphoma/leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
3
Promethazine Approved, Investigational Phase 2 60-87-7 4927
4
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
5
Daratumumab Approved Phase 2 945721-28-8
6
Ranitidine Approved Phase 2 66357-35-5, 66357-59-3 3001055
7
Histamine Approved, Investigational Phase 2 51-45-6, 75614-87-8 774
8
Acetaminophen Approved Phase 2 103-90-2 1983
9
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
10 Hormone Antagonists Phase 2
11 Central Nervous System Depressants Phase 2
12 Histamine H2 Antagonists Phase 2
13 Antibodies Phase 2
14 Autonomic Agents Phase 2
15 Anti-Allergic Agents Phase 2
16 Citrate Phase 2
17 glucocorticoids Phase 2
18 Anesthetics Phase 2
19 Antineoplastic Agents, Hormonal Phase 2
20 Anti-Ulcer Agents Phase 2
21 Anesthetics, Local Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
23 Analgesics, Non-Narcotic Phase 2
24 HIV Protease Inhibitors Phase 2
25 Pharmaceutical Solutions Phase 2
26 Antiemetics Phase 2
27 Antacids Phase 2
28 Anti-Inflammatory Agents Phase 2
29 Antipyretics Phase 2
30 Neurotransmitter Agents Phase 2
31 Dermatologic Agents Phase 2
32
protease inhibitors Phase 2
33 Ranitidine bismuth citrate Phase 2
34 Peripheral Nervous System Agents Phase 2
35 Histamine H1 Antagonists Phase 2
36 Histamine Antagonists Phase 2
37 Gastrointestinal Agents Phase 2
38 Hypnotics and Sedatives Phase 2
39
Histamine Phosphate Phase 2 51-74-1 65513
40 Antibodies, Monoclonal Phase 2
41 BB 1101 Phase 2
42
Bismuth Phase 2 7440-69-9 16682734 105143
43 Bismuth tripotassium dicitrate Phase 2
44 Hormones Phase 2
45 Immunoglobulins Phase 2
46 Antipruritics Phase 2
47 Analgesics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Isatuximab in Lymphoblastic Leukemia Terminated NCT02999633 Phase 2 Isatuximab SAR650984;dexamethasone;dexamethasone;acetaminophen;ranitidine;diphenhydramine

Search NIH Clinical Center for Precursor T-Lymphoblastic Lymphoma/leukemia

Genetic Tests for Precursor T-Lymphoblastic Lymphoma/leukemia

Anatomical Context for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards organs/tissues related to Precursor T-Lymphoblastic Lymphoma/leukemia:

41
T Cells

Publications for Precursor T-Lymphoblastic Lymphoma/leukemia

Articles related to Precursor T-Lymphoblastic Lymphoma/leukemia:

# Title Authors Year
1
Flow cytometry in the diagnosis of mediastinal tumors with emphasis on differentiating thymocytes from precursor T-lymphoblastic lymphoma/leukemia. ( 15160915 )
2004
2
Translocation (5;17)(q13;q21) in a case with precursor T-lymphoblastic lymphoma/leukemia. ( 11801318 )
2002
3
Immunoperoxidase detection of CD10 in Precursor T-lymphoblastic lymphoma/leukemia: a clinicopathologic study of 24 cases. ( 10782151 )
2000

Variations for Precursor T-Lymphoblastic Lymphoma/leukemia

Expression for Precursor T-Lymphoblastic Lymphoma/leukemia

Search GEO for disease gene expression data for Precursor T-Lymphoblastic Lymphoma/leukemia.

Pathways for Precursor T-Lymphoblastic Lymphoma/leukemia

Pathways related to Precursor T-Lymphoblastic Lymphoma/leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 IRF6 MME

GO Terms for Precursor T-Lymphoblastic Lymphoma/leukemia

Sources for Precursor T-Lymphoblastic Lymphoma/leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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