MCID: PRC018
MIFTS: 23

Precursor T-Lymphoblastic Lymphoma/leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards integrated aliases for Precursor T-Lymphoblastic Lymphoma/leukemia:

Name: Precursor T-Lymphoblastic Lymphoma/leukemia 12 15
Precursor T Cell Lymphoblastic Leukemia/lymphoblastic Lymphoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5599
UMLS 73 C1301359

Summaries for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards based summary : Precursor T-Lymphoblastic Lymphoma/leukemia, also known as precursor t cell lymphoblastic leukemia/lymphoblastic lymphoma, is related to childhood precursor t-lymphoblastic lymphoma/leukemia and precursor t-lymphoblastic lymphoma/leukemia refractory. An important gene associated with Precursor T-Lymphoblastic Lymphoma/leukemia is IRF6 (Interferon Regulatory Factor 6), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ranitidine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include t cells.

Related Diseases for Precursor T-Lymphoblastic Lymphoma/leukemia

Graphical network of the top 20 diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia:



Diseases related to Precursor T-Lymphoblastic Lymphoma/leukemia

Symptoms & Phenotypes for Precursor T-Lymphoblastic Lymphoma/leukemia

Drugs & Therapeutics for Precursor T-Lymphoblastic Lymphoma/leukemia

Drugs for Precursor T-Lymphoblastic Lymphoma/leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranitidine Approved Phase 2 66357-59-3, 66357-35-5 3001055
2
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
3
Acetaminophen Approved Phase 2 103-90-2 1983
4
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
5
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
6
Promethazine Approved, Investigational Phase 2 60-87-7 4927
7
Daratumumab Approved Phase 2 945721-28-8
8
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
9 Ranitidine bismuth citrate Phase 2
10
Bismuth Phase 2 7440-69-9 16682734 105143
11
Histamine Phosphate Phase 2 51-74-1 65513
12 Dexamethasone acetate Phase 2 1177-87-3
13 Analgesics Phase 2
14 glucocorticoids Phase 2
15
protease inhibitors Phase 2
16 Central Nervous System Depressants Phase 2
17 Gastrointestinal Agents Phase 2
18 Neurotransmitter Agents Phase 2
19 Analgesics, Non-Narcotic Phase 2
20 Histamine Antagonists Phase 2
21 Histamine H1 Antagonists Phase 2
22 Histamine H2 Antagonists Phase 2
23 HIV Protease Inhibitors Phase 2
24 Anesthetics Phase 2
25 Hormone Antagonists Phase 2
26 Dermatologic Agents Phase 2
27 Anesthetics, Local Phase 2
28 Hormones Phase 2
29 Antacids Phase 2
30 Anti-Allergic Agents Phase 2
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
32 Peripheral Nervous System Agents Phase 2
33 Hypnotics and Sedatives Phase 2
34 Pharmaceutical Solutions Phase 2
35 Antibodies Phase 2
36 Immunoglobulins Phase 2
37 Antibodies, Monoclonal Phase 2
38 Antiemetics Phase 2
39 Anti-Inflammatory Agents Phase 2
40 Antipruritics Phase 2
41 Antipyretics Phase 2
42 Anti-Ulcer Agents Phase 2
43 BB 1101 Phase 2
44 Autonomic Agents Phase 2
45 Bismuth tripotassium dicitrate Phase 2
46 Antineoplastic Agents, Hormonal Phase 2
47 Citrate Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Isatuximab in Lymphoblastic Leukemia Terminated NCT02999633 Phase 2 Isatuximab SAR650984;dexamethasone;dexamethasone;acetaminophen;ranitidine;diphenhydramine

Search NIH Clinical Center for Precursor T-Lymphoblastic Lymphoma/leukemia

Genetic Tests for Precursor T-Lymphoblastic Lymphoma/leukemia

Anatomical Context for Precursor T-Lymphoblastic Lymphoma/leukemia

MalaCards organs/tissues related to Precursor T-Lymphoblastic Lymphoma/leukemia:

41
T Cells

Publications for Precursor T-Lymphoblastic Lymphoma/leukemia

Articles related to Precursor T-Lymphoblastic Lymphoma/leukemia:

# Title Authors Year
1
Flow cytometry in the diagnosis of mediastinal tumors with emphasis on differentiating thymocytes from precursor T-lymphoblastic lymphoma/leukemia. ( 15160915 )
2004
2
Translocation (5;17)(q13;q21) in a case with precursor T-lymphoblastic lymphoma/leukemia. ( 11801318 )
2002
3
Immunoperoxidase detection of CD10 in Precursor T-lymphoblastic lymphoma/leukemia: a clinicopathologic study of 24 cases. ( 10782151 )
2000

Variations for Precursor T-Lymphoblastic Lymphoma/leukemia

Expression for Precursor T-Lymphoblastic Lymphoma/leukemia

Search GEO for disease gene expression data for Precursor T-Lymphoblastic Lymphoma/leukemia.

Pathways for Precursor T-Lymphoblastic Lymphoma/leukemia

Pathways related to Precursor T-Lymphoblastic Lymphoma/leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 CD79A IRF6
2 11.02 CD79A MME
3 10.49 IRF6 MME

GO Terms for Precursor T-Lymphoblastic Lymphoma/leukemia

Sources for Precursor T-Lymphoblastic Lymphoma/leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....