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MCID: PRD004
MIFTS: 45

Prediabetes Syndrome

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Prediabetes Syndrome

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MalaCards integrated aliases for Prediabetes Syndrome:

Name: Prediabetes Syndrome 12 15 73
Prediabetic State 12 55 44
Prediabetes 12 43

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11716
ICD10 33 R73.09
MeSH 44 D011236
NCIt 50 C122685
UMLS 73 C0362046
Sources

Summaries for Prediabetes Syndrome

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MedlinePlus : 43 Prediabetes means you have blood glucose, or blood sugar, levels that are higher than normal but not high enough to be called diabetes. Glucose comes from the foods you eat. Too much glucose in your blood can damage your body over time. If you have prediabetes, you are more likely to develop type 2 diabetes, heart disease, and stroke. Most people with prediabetes don't have any symptoms. Your doctor can use an A1C test or another blood test to find out if your blood glucose levels are higher than normal. If you are 45 years old or older, your doctor may recommend that you be tested for prediabetes, especially if you are overweight. Losing weight - at least 5 to 10 percent of your starting weight - can prevent or delay diabetes or even reverse prediabetes. That's 10 to 20 pounds for someone who weighs 200 pounds. You can lose weight by cutting down on the amount of calories and fat you eat and being physically active at least 30 minutes a day. Being physically active makes your body's insulin work better. Your doctor may also prescribe medicine to help control the amount of glucose in your blood. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Prediabetes Syndrome, also known as prediabetic state, is related to nonalcoholic steatohepatitis and fatty liver disease. An important gene associated with Prediabetes Syndrome is INS (Insulin), and among its related pathways/superpathways are Glucose / Energy Metabolism and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Metformin and Saxagliptin have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 76 Prediabetes is the precursor stage before diabetes mellitus in which not all of the symptoms required to... more...

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Related Diseases for Prediabetes Syndrome

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Diseases related to Prediabetes Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 nonalcoholic steatohepatitis 32.7 ADIPOQ INS LEP
2 fatty liver disease 30.7 ADIPOQ APOB IL6 INS LEP PPARG
3 gestational diabetes 30.1 ADIPOQ INS LEP TCF7L2
4 liver disease 29.9 ADIPOQ ALB INS LEP
5 deficiency anemia 29.8 ALB CRP IL6
6 hyperuricemia 29.8 APOB CRP INS
7 apnea, obstructive sleep 29.3 ADIPOQ CRP IL6 INS LEP
8 sleep apnea 29.3 ADIPOQ CRP IL6 INS LEP
9 cerebrovascular disease 29.1 APOB CRP IL6 INS
10 coronary heart disease 1 28.9 ADIPOQ APOB COG2 CRP INS
11 hypercholesterolemia, familial 28.9 APOB COG2 CRP INS
12 glucose intolerance 28.8 ADIPOQ DPP4 GCG INS LEP
13 heart disease 28.5 ADIPOQ ALB APOB CRP IL6 INS
14 hypertension, essential 28.2 ADIPOQ ALB APOB CRP INS LEP
15 hyperglycemia 28.0 ADIPOQ ALB DPP4 GCG INS LEP
16 morbid obesity 28.0 ADIPOQ CRP GCG INS LEP PPARG
17 coronary artery anomaly 27.9 ADIPOQ APOB COG2 CRP IL6 INS
18 lipid metabolism disorder 27.6 ADIPOQ APOB COG2 CRP INS LEP
19 arteriosclerosis 27.5 ADIPOQ APOB COG2 CRP IL6 INS
20 myocardial infarction 27.3 ADIPOQ ALB APOB COG2 CRP IL6
21 arteries, anomalies of 26.4 ADIPOQ ALB APOB COG2 CRP IL6
22 diabetes mellitus, noninsulin-dependent 25.6 ADIPOQ ALB APOB COG2 CRP DPP4
23 diabetes mellitus 25.1 ADIPOQ ALB APOB COG2 CRP DPP4
24 malignant otitis externa 10.8 CRP INS
25 autoimmune polyendocrine syndrome, type ii 10.8 GAD1 INS
26 acquired generalized lipodystrophy 10.8 ADIPOQ LEP
27 idiopathic recurrent pericarditis 10.7 ADIPOQ LEP
28 severe nonproliferative diabetic retinopathy 10.7 ALB INS
29 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.7 ADIPOQ INS
30 lipodystrophy, familial partial, type 2 10.7 INS LEP
31 idiopathic edema 10.7 ADIPOQ INS PPARG
32 cold agglutinin disease 10.7 CRP IL6
33 abdominal tuberculosis 10.6 ALB CRP
34 cryopyrin-associated periodic syndrome 10.6 CRP IL6
35 familial partial lipodystrophy 10.6 INS LEP PPARG
36 cardiogenic shock 10.6 CRP IL6
37 burns 10.6 ALB INS
38 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.6 CRP INS LEP
39 pyuria 10.6 ALB CRP
40 acute cholangitis 10.5 CRP IL6
41 neutrophilia, hereditary 10.5 CRP IL6
42 obesity-hypoventilation syndrome 10.5 ADIPOQ IL6 LEP
43 severe pre-eclampsia 10.4 ADIPOQ ALB LEP
44 uremic pruritus 10.4 CRP IL6
45 chronic ulcer of skin 10.4 ALB CRP
46 nutritional deficiency disease 10.4 ALB CRP LEP
47 hypersensitivity reaction type iii disease 10.4 ALB CRP IL6
48 sleep disorder 10.4 CRP IL6 LEP
49 acute cystitis 10.4 ALB CRP IL6
50 acute pyelonephritis 10.4 ALB CRP IL6

Graphical network of the top 20 diseases related to Prediabetes Syndrome:



Diseases related to Prediabetes Syndrome
Sources

Symptoms & Phenotypes for Prediabetes Syndrome

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MGI Mouse Phenotypes related to Prediabetes Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 PPARG SLC30A8 TCF7L2 APOB LEP COG2
2 growth/size/body region MP:0005378 10.11 PPARG SLC30A8 TCF7L2 APOB COG2 LEP
3 endocrine/exocrine gland MP:0005379 10.1 PPARG SLC30A8 TCF7L2 LEP DPP4 GAD1
4 cardiovascular system MP:0005385 10.03 PPARG TCF7L2 INS APOB CRP LEP
5 adipose tissue MP:0005375 9.93 PPARG TCF7L2 INS LEP ADIPOQ IL6
6 liver/biliary system MP:0005370 9.91 PPARG SLC30A8 TCF7L2 LEP ADIPOQ IL6
7 muscle MP:0005369 9.76 PPARG TCF7L2 APOB LEP ADIPOQ IL6
8 neoplasm MP:0002006 9.43 PPARG TCF7L2 LEP ADIPOQ IL6 ALB
9 renal/urinary system MP:0005367 9.17 PPARG TCF7L2 LEP ADIPOQ IL6 ALB
Sources

Drugs & Therapeutics for Prediabetes Syndrome

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Drugs for Prediabetes Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 430)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Saxagliptin Approved Phase 4,Phase 3,Not Applicable 361442-04-8 11243969
3
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
4
Curcumin Approved, Investigational Phase 4 458-37-7 969516
5
Benzocaine Approved, Investigational Phase 4,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
6
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
7
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
8
Ticagrelor Approved Phase 4 274693-27-5 9871419
9
Ticlopidine Approved Phase 4 55142-85-3 5472
10
Insulin Glargine Approved Phase 4,Phase 3,Phase 1,Not Applicable 160337-95-1
11
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 23994
12
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 141758-74-9 15991534
13
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
14
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10102-43-9 145068 160954
15
Simvastatin Approved Phase 4,Phase 2,Phase 3,Not Applicable 79902-63-9 54454
16
Acarbose Approved, Investigational Phase 4,Phase 3 56180-94-0 441184
17
Hydroxychloroquine Approved Phase 4 118-42-3 3652
18
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
19
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
20
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
21
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 111025-46-8 4829
22
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
23
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
24
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 5284616 6436030 46835353
25
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
26
Insulin Aspart Approved Phase 4,Phase 2,Phase 3 116094-23-6 16132418
27
Insulin Lispro Approved Phase 4,Phase 3,Phase 2 133107-64-9
28
Fluspirilene Approved, Investigational Phase 4 1841-19-6 3396
29
Pravastatin Approved Phase 4 81093-37-0 54687
30
Linagliptin Approved Phase 4,Not Applicable 668270-12-0 10096344
31
Adalimumab Approved Phase 4 331731-18-1 16219006
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
33
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
34
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
35 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Not Applicable
36
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1406-16-2
37
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 67-97-0 6221 5280795
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 50-14-6 5280793
39
Menadione Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-27-5 4055
40
Phytonadione Approved, Investigational, Nutraceutical Phase 4,Phase 1,Phase 2 84-80-0 4812 5284607
41
Niacin Approved, Investigational, Nutraceutical Phase 4,Not Applicable 59-67-6 938
42
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Not Applicable 98-92-0 936
43
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 77-92-9 311
44
2,4-thiazolidinedione Investigational Phase 4,Phase 2,Not Applicable 2295-31-0
45
Menatetrenone Investigational Phase 4 863-61-6 5282367
46 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
47 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
48 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 758)
# Name Status NCT ID Phase Drugs
1 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
2 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Unknown status NCT02051842 Phase 4 Metadoxine
3 Sitagliptin and Brown Adipose Tissue Unknown status NCT02294084 Phase 4 Sitagliptin;placebo
4 Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance Unknown status NCT01052025 Phase 4 Curcumin
5 Intensity of Exercise and Glucose Metabolism Unknown status NCT01649219 Phase 4
6 Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study Unknown status NCT02409238 Phase 4 Metformin
7 PRotective Effect on the Coronary Microcirculation of Patients With DIabetes by Clopidogrel or Ticagrelor Unknown status NCT02698618 Phase 4 Randomization
8 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
9 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4 Anakinra;TNF alpha inhibitors
10 Inflammatory Axis and Sirtuins' in Overweight Pre-diabetics Patients Completed NCT03491241 Phase 4 Metformin
11 Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes Completed NCT02700334 Phase 4 Dapagliflozin;Placebo
12 Effects of Antidiabetic Medications on the Postprandial State in Prediabetes Completed NCT02104739 Phase 4 Exenatide;Saxagliptin;Exenatide extended-release (ER)
13 Effect of Rubus Occidentalis Extract on Plasma Glucose Levels in Subject With Prediabetes Completed NCT01964703 Phase 4 Rubus occidentalis extract
14 Metformin and Longevity Genes in Prediabetes Completed NCT01765946 Phase 4 Metformin;placebo
15 Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study) Completed NCT00928005 Phase 4
16 Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus Completed NCT01436916 Phase 4 oral cholecalciferol + life style counselling;placebo + life style counselling
17 Development of Pre-pregnancy Intervention to Reduce the Risk of Diabetes and Prediabetes Completed NCT02617693 Phase 4
18 Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes Completed NCT02689765 Phase 4
19 Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2 Completed NCT01497132 Phase 4 Vitamin D3;Placebo
20 Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes Completed NCT01326533 Phase 4 hydroxychloroquine
21 Acute Impact of Intramuscular (IM) Aripiprazole and Olanzapine on Insulin Resistance in High Risk Prediabetics Completed NCT01411930 Phase 4 Intramuscular olanzapine, aripiprazole;Intramuscular aripiprazole, olanzapine
22 Physical Exercise Versus Rosiglitazone in CAD and Prediabetes Completed NCT00675740 Phase 4 rosiglitazone
23 Evaluation of the Translation of the DE-PLAN Program for the Primary Prevention of Type 2 Diabetes in Routine Primary Care Completed NCT01365013 Phase 4
24 The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes Completed NCT00546728 Phase 4 Exenatide;Metformin
25 Study to Determine the Effects of Human Growth Hormone and Pioglitazone in Overweight, Prediabetic Adults Completed NCT00352287 Phase 4 Recombinant human growth hormone; pioglitazone
26 Incretins in Impaired Fasting Glucose Completed NCT00364377 Phase 4 Sitagliptin
27 Mechanisms Underlying Metabolic Syndrome in Obesity Completed NCT00579813 Phase 4 Pioglitazone
28 The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion Completed NCT01056497 Phase 4 alpha lipoic acid
29 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
30 The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes Completed NCT01181986 Phase 4 Exenatide SC;Exenatide IV;Placebo SC;Exendin-9;Placebo IV
31 Effect of DPP4 Inhibition on Growth Hormone Secretion Completed NCT01701973 Phase 4 Sitagliptin;Pegvisomant;Placebo;L-NMMA;Exendin 9-39
32 Metformin in Insulin Resistant Left Ventricular (LV) Dysfunction (TAYSIDE Trial) Completed NCT00473876 Phase 4 Metformin;Matched Placebo (Capsules)
33 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
34 Niacin, N-3 Fatty Acids and Insulin Resistance Completed NCT00286234 Phase 4 omega-3 acid ethyl esters;extended release niacin;placebo;omega-3 acid ethyl esters;combined treatment
35 Metformin in Longevity Study (MILES). Completed NCT02432287 Phase 4 Metformin;Placebo
36 Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM Completed NCT01856907 Phase 4 Sitagliptin-Metformin;Metformin;Placebo pill
37 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
38 MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease Completed NCT02226510 Phase 4 Metformin XL;Placebo
39 Assessing DSA Formation, Diabetes, Viral Infections, Structural Kidney Changes With an Everolimus-based Regimen (ADVISE) Completed NCT02316938 Phase 4 Everolimus and reduced CNI;Calcineurin Inhibitor and MPA
40 Sitagliptin Therapy in Hospitalized Patients With Type 2 Diabetes Completed NCT01845831 Phase 4 Sitagliptin;Basal Bolus;Metformin and Sitagliptin;Glargine;Glargine 50%;Glargine 80%
41 Coronary Artery Disease Progression in Patients With Prediabetes Recruiting NCT02744976 Phase 4 Metformin
42 Improving Beta Cell Function in Mexican American Women With Prediabetes Recruiting NCT02488057 Phase 4 Liraglutide
43 China Protection Trial of Glucose Metabolism by Pitavastatin in Patients With Prediabetes and Hypertension Recruiting NCT03532620 Phase 4 Pitavastatin Calcium;Atorvastatin Calcium
44 Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes Recruiting NCT02754739 Phase 4 Pravastatin;Placebo (for Pravastatin)
45 Dapagliflozin in Type 2 Diabetes or Pre-diabetes, and PRESERVED Ejection Fraction Heart Failure Recruiting NCT03030235 Phase 4 Dapagliflozin 10Mg Oral Tablet;Dapagliflozin matching placebo
46 Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients. Recruiting NCT03398356 Phase 4 Metformin
47 Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness Recruiting NCT02167620 Phase 4 Metformin;Placebo
48 Efficacy of Metformin in Preventing Diabetes in China Recruiting NCT03441750 Phase 4 metformin
49 Hospital-based Diabetes Prevention Study in Korea Recruiting NCT02981121 Phase 4 Metformin
50 Cardiovascular Effects of GLP-1 Receptor Activation Recruiting NCT03101930 Phase 4 Liraglutide;Sitagliptin;Placebos;Exendin (9-39)

Search NIH Clinical Center for Prediabetes Syndrome

Cochrane evidence based reviews: prediabetic state

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Genetic Tests for Prediabetes Syndrome

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Anatomical Context for Prediabetes Syndrome

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MalaCards organs/tissues related to Prediabetes Syndrome:

41
Testes, Heart, Kidney, Endothelial, Ovary, Bone, Skeletal Muscle
Sources

Publications for Prediabetes Syndrome

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Articles related to Prediabetes Syndrome:

# Title Authors Year
1
Cardiovascular risk factors and the prediabetic syndrome. ( 8862692 )
1996
Sources

Variations for Prediabetes Syndrome

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Expression for Prediabetes Syndrome

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Search GEO for disease gene expression data for Prediabetes Syndrome.
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Pathways for Prediabetes Syndrome

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Pathways related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Glucose / Energy Metabolism 4
12.29 ADIPOQ GAD1 GCG INS PPARG
2
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.19 ADIPOQ INS LEP PPARG
4
Folate Metabolism 1
Show member pathways
 12.05 ALB APOB CRP IL6 INS
5
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.81 ALB IL6 INS
6
Peptide hormone metabolism 66
Show member pathways
 11.69 DPP4 GCG INS LEP SLC30A8 TCF7L2
7
Adipogenesis 1
11.67 ADIPOQ IL6 INS LEP PPARG
8
Incretin synthesis, secretion, and inactivation 66
Show member pathways
 11.31 DPP4 GCG LEP TCF7L2
9
FOXA1 transcription factor network 1
Show member pathways
 11.27 APOB GCG INS
10
Differentiation of white and brown adipocyte 1
10.94 ADIPOQ LEP PPARG
11
Overview of nanoparticle effects 1
10.77 CRP IL6
12
Transcription factor regulation in adipogenesis 1
10.27 ADIPOQ IL6 LEP PPARG
Sources

GO Terms for Prediabetes Syndrome

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Cellular components related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ADIPOQ ALB APOB CRP GCG IL6
2 endoplasmic reticulum lumen GO:0005788 9.55 ALB APOB GCG IL6 INS
3 extracellular region GO:0005576 9.32 ADIPOQ ALB APOB CRP DPP4 GCG
4 endosome lumen GO:0031904 9.26 APOB INS

Biological processes related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 ALB GCG IL6 INS LEP
2 positive regulation of gene expression GO:0010628 9.93 APOB CRP IL6 INS
3 cellular protein metabolic process GO:0044267 9.8 ALB APOB IL6 INS
4 regulation of signaling receptor activity GO:0010469 9.8 ADIPOQ GCG IL6 INS LEP
5 response to organic substance GO:0010033 9.75 APOB INS PPARG
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 ADIPOQ IL6 INS
7 response to nutrient GO:0007584 9.7 ADIPOQ LEP PPARG
8 regulation of insulin secretion GO:0050796 9.69 DPP4 GCG LEP
9 glucose metabolic process GO:0006006 9.65 ADIPOQ INS LEP
10 lipoprotein transport GO:0042953 9.62 APOB PPARG
11 positive regulation of cellular protein metabolic process GO:0032270 9.62 ADIPOQ INS
12 positive regulation of insulin receptor signaling pathway GO:0046628 9.61 INS LEP
13 regulation of fat cell differentiation GO:0045598 9.61 LEP PPARG
14 response to nutrient levels GO:0031667 9.61 ADIPOQ INS LEP
15 fatty acid oxidation GO:0019395 9.6 ADIPOQ PPARG
16 negative regulation of collagen biosynthetic process GO:0032966 9.59 IL6 PPARG
17 locomotory exploration behavior GO:0035641 9.58 DPP4 GAD1
18 negative regulation of gluconeogenesis GO:0045721 9.57 ADIPOQ INS
19 response to glucose GO:0009749 9.56 ADIPOQ INS SLC30A8 TCF7L2
20 negative regulation of blood vessel diameter GO:0097756 9.54 CRP INS
21 acute-phase response GO:0006953 9.54 CRP IL6 INS
22 negative regulation of acute inflammatory response GO:0002674 9.46 INS PPARG
23 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.33 ADIPOQ CRP PPARG
24 cellular response to prostaglandin stimulus GO:0071379 9.32 APOB PPARG
25 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 LEP
26 glucose homeostasis GO:0042593 9.1 ADIPOQ INS LEP PPARG SLC30A8 TCF7L2

Molecular functions related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ADIPOQ ALB CRP DPP4 GCG INS
2 low-density lipoprotein particle receptor binding GO:0050750 9.16 APOB CRP
3 hormone activity GO:0005179 8.92 ADIPOQ GCG INS LEP
Sources

Sources for Prediabetes Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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