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MCID: PRD004
MIFTS: 48

Prediabetes Syndrome

Categories: Blood diseases, Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Prediabetes Syndrome

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MalaCards integrated aliases for Prediabetes Syndrome:

Name: Prediabetes Syndrome 12 15 73
Prediabetic State 12 55 44
Prediabetes 12 43 15

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11716
ICD10 33 R73.03
MeSH 44 D011236
NCIt 50 C122685
SNOMED-CT 68 15777000 9414007
UMLS 73 C0362046
Sources

Summaries for Prediabetes Syndrome

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MedlinePlus : 43 Prediabetes means you have blood glucose, or blood sugar, levels that are higher than normal but not high enough to be called diabetes. Glucose comes from the foods you eat. Too much glucose in your blood can damage your body over time. If you have prediabetes, you are more likely to develop type 2 diabetes, heart disease, and stroke. Most people with prediabetes don't have any symptoms. Your doctor can use an A1C test or another blood test to find out if your blood glucose levels are higher than normal. If you are 45 years old or older, your doctor may recommend that you be tested for prediabetes, especially if you are overweight. Losing weight - at least 5 to 10 percent of your starting weight - can prevent or delay diabetes or even reverse prediabetes. That's 10 to 20 pounds for someone who weighs 200 pounds. You can lose weight by cutting down on the amount of calories and fat you eat and being physically active at least 30 minutes a day. Being physically active makes your body's insulin work better. Your doctor may also prescribe medicine to help control the amount of glucose in your blood. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Prediabetes Syndrome, also known as prediabetic state, is related to nonalcoholic steatohepatitis and fatty liver disease. An important gene associated with Prediabetes Syndrome is INS (Insulin), and among its related pathways/superpathways are Glucose / Energy Metabolism and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Metformin and Saxagliptin have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 76 Prediabetes is the precursor stage before diabetes mellitus in which not all of the symptoms required to... more...

Sources

Related Diseases for Prediabetes Syndrome

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Diseases related to Prediabetes Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 nonalcoholic steatohepatitis 32.4 ADIPOQ INS LEP
2 fatty liver disease 32.2 ADIPOQ IL6 INS LEP
3 gestational diabetes 30.3 ADIPOQ INS LEP TCF7L2
4 diabetes mellitus, noninsulin-dependent 30.3 ADIPOQ ALB APOB COG2 CRP DPP4
5 fatty liver disease, nonalcoholic 1 30.2 ADIPOQ INS LEP
6 diabetes mellitus 30.2 ADIPOQ ALB APOB COG2 CRP DPP4
7 peripheral nervous system disease 30.1 ALB IL6 INS
8 deficiency anemia 30.1 ALB CRP IL6
9 liver disease 30.0 ADIPOQ ALB IL6 INS LEP
10 hyperinsulinism 29.9 APOB INS LEP
11 hyperuricemia 29.8 APOB CRP INS
12 hyperglycemia 29.8 ADIPOQ ALB DPP4 GCG INS LEP
13 sleep apnea 29.7 ADIPOQ CRP IL6 INS LEP
14 heart disease 29.7 ALB APOB CRP IL6 INS
15 diabetes mellitus, ketosis-prone 29.7 GAD1 INS SLC30A8
16 endocarditis 29.7 ALB CRP IL6
17 glucose intolerance 29.6 ADIPOQ APOB CRP DPP4 GCG INS
18 lipid metabolism disorder 29.6 ADIPOQ APOB COG2 CRP INS LEP
19 ischemic heart disease 29.6 APOB CRP IL6
20 coronary artery anomaly 29.5 APOB COG2 CRP
21 coronary heart disease 1 29.5 ADIPOQ APOB COG2 CRP IL6 INS
22 kidney disease 29.5 ADIPOQ ALB CRP IL6 INS
23 hypercholesterolemia, familial 29.5 APOB COG2 CRP INS
24 peripheral vascular disease 29.4 ALB APOB CRP IL6
25 morbid obesity 29.4 ADIPOQ CRP GCG INS LEP PPARG
26 cerebrovascular disease 29.3 ADIPOQ APOB CRP IL6 INS
27 nonalcoholic fatty liver disease 29.3 ADIPOQ APOB CRP IL6 INS LEP
28 hypertension, essential 29.2 ADIPOQ ALB APOB CRP INS LEP
29 vascular disease 29.0 ADIPOQ ALB APOB CRP IL6 INS
30 arteriosclerosis 29.0 ADIPOQ APOB COG2 CRP IL6 INS
31 myocardial infarction 29.0 ADIPOQ ALB APOB COG2 CRP IL6
32 arteries, anomalies of 28.7 ADIPOQ ALB APOB COG2 CRP IL6
33 body mass index quantitative trait locus 11 28.5 ADIPOQ APOB COG2 CRP DPP4 GCG
34 malignant otitis externa 10.3 CRP INS
35 autoimmune polyendocrine syndrome, type ii 10.3 GAD1 INS
36 idiopathic recurrent pericarditis 10.2 ADIPOQ LEP
37 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.2 ADIPOQ INS
38 severe nonproliferative diabetic retinopathy 10.2 ALB INS
39 idiopathic edema 10.2 ADIPOQ INS PPARG
40 burns 10.2 CRP INS
41 cold agglutinin disease 10.2 CRP IL6
42 gastrointestinal tuberculosis 10.2 ALB CRP
43 lipodystrophy, congenital generalized, type 1 10.2 ADIPOQ INS LEP
44 lipodystrophy, familial partial, type 1 10.2 INS LEP PPARG
45 abdominal tuberculosis 10.2 ALB CRP
46 endocrine pancreas disease 10.2 ADIPOQ INS LEP
47 complete generalized lipodystrophy 10.2 INS LEP PPARG
48 pyuria 10.2 ALB CRP
49 familial partial lipodystrophy 10.2 INS LEP PPARG
50 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.2 CRP INS LEP

Graphical network of the top 20 diseases related to Prediabetes Syndrome:



Diseases related to Prediabetes Syndrome
Sources

Symptoms & Phenotypes for Prediabetes Syndrome

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MGI Mouse Phenotypes related to Prediabetes Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ADIPOQ ALB APOB COG2 CRP DPP4
2 growth/size/body region MP:0005378 10.11 ADIPOQ APOB COG2 DPP4 GAD1 IL6
3 endocrine/exocrine gland MP:0005379 10.1 ADIPOQ ALB DPP4 GAD1 IL6 INS
4 cardiovascular system MP:0005385 10.03 ADIPOQ APOB CRP IL6 INS LEP
5 adipose tissue MP:0005375 9.93 ADIPOQ IL6 INS LEP PPARG TCF7L2
6 liver/biliary system MP:0005370 9.91 ADIPOQ ALB APOB IL6 INS LEP
7 muscle MP:0005369 9.76 ADIPOQ ALB APOB IL6 INS LEP
8 neoplasm MP:0002006 9.43 ADIPOQ ALB IL6 LEP PPARG TCF7L2
9 renal/urinary system MP:0005367 9.17 ADIPOQ ALB IL6 INS LEP PPARG
Sources

Drugs & Therapeutics for Prediabetes Syndrome

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Drugs for Prediabetes Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 446)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Saxagliptin Approved Phase 4,Phase 3,Not Applicable 361442-04-8 11243969
3
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
4
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
5
Benzocaine Approved, Investigational Phase 4,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
6 tannic acid Approved Phase 4,Phase 2,Not Applicable
7
Ticagrelor Approved Phase 4 274693-27-5 9871419
8
Ticlopidine Approved Phase 4 55142-85-3 5472
9
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
10
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
11
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6
12
Insulin Glargine Approved Phase 4,Phase 3,Phase 1,Not Applicable 160337-95-1
13
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 141758-74-9 15991534
14
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
15
Testosterone enanthate Approved Phase 4,Phase 3 315-37-7 9416
16
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
17
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3 5949-44-0
18
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
19
Simvastatin Approved Phase 4,Phase 2,Phase 3,Not Applicable 79902-63-9 54454
20
Nitric Oxide Approved Phase 4,Phase 2,Phase 3,Not Applicable 10102-43-9 145068
21
Acarbose Approved, Investigational Phase 4,Phase 3 56180-94-0 441184
22
Pravastatin Approved Phase 4 81093-37-0 54687
23
Bilberry Approved, Experimental Phase 4
24
Hydroxychloroquine Approved Phase 4 118-42-3 3652
25
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
26
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
27
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
28
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 111025-46-8 4829
29
Phytonadione Approved, Investigational Phase 4,Phase 1,Phase 2 84-80-0 4812 5284607
30
Nicotinamide Approved, Investigational Phase 4,Not Applicable 98-92-0 936
31
Insulin Aspart Approved Phase 4,Phase 2,Phase 3 116094-23-6 16132418
32
Insulin Lispro Approved Phase 4,Phase 3,Phase 2 133107-64-9
33
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
34
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
35
Fluspirilene Approved, Investigational Phase 4 1841-19-6 3396
36
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 5282452 6366718
37
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
38 Nutmeg Approved Phase 4
39
Linagliptin Approved Phase 4,Not Applicable 668270-12-0 10096344
40
Adalimumab Approved Phase 4 331731-18-1 16219006
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
42
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1406-16-2
44
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 67-97-0 5280795 6221
45
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 50-14-6 5280793
46
Menadione Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-27-5 4055
47
Niacin Approved, Investigational, Nutraceutical Phase 4,Not Applicable 59-67-6 938
48
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 77-92-9 311
49
2,4-thiazolidinedione Investigational Phase 4,Phase 2,Not Applicable 2295-31-0
50
Menatetrenone Investigational Phase 4 863-61-6 5282367

Interventional clinical trials:

(show top 50) (show all 824)
# Name Status NCT ID Phase Drugs
1 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
2 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Unknown status NCT02051842 Phase 4 Metadoxine
3 Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance Unknown status NCT01052025 Phase 4 Curcumin
4 Intensity of Exercise and Glucose Metabolism Unknown status NCT01649219 Phase 4
5 Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study Unknown status NCT02409238 Phase 4 Metformin
6 PRotective Effect on the Coronary Microcirculation of Patients With DIabetes by Clopidogrel or Ticagrelor Unknown status NCT02698618 Phase 4 Randomization
7 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
8 Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes Completed NCT02700334 Phase 4 Dapagliflozin;Placebo
9 Effects of Antidiabetic Medications on the Postprandial State in Prediabetes Completed NCT02104739 Phase 4 Exenatide;Saxagliptin;Exenatide extended-release (ER)
10 Effect of Rubus Occidentalis Extract on Plasma Glucose Levels in Subject With Prediabetes Completed NCT01964703 Phase 4 Rubus occidentalis extract
11 Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes Completed NCT02754739 Phase 4 Pravastatin;Placebo (for Pravastatin)
12 Metformin and Longevity Genes in Prediabetes Completed NCT01765946 Phase 4 Metformin;placebo
13 Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study) Completed NCT00928005 Phase 4
14 Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus Completed NCT01436916 Phase 4 oral cholecalciferol + life style counselling;placebo + life style counselling
15 Development of Pre-pregnancy Intervention to Reduce the Risk of Diabetes and Prediabetes Completed NCT02617693 Phase 4
16 Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes Completed NCT02689765 Phase 4
17 Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness Completed NCT02167620 Phase 4 Metformin;Placebo
18 Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2 Completed NCT01497132 Phase 4 Vitamin D3;Placebo
19 Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes Completed NCT01326533 Phase 4 hydroxychloroquine
20 Sitagliptin and Brown Adipose Tissue Completed NCT02294084 Phase 4 Sitagliptin;placebo
21 Acute Impact of Intramuscular (IM) Aripiprazole and Olanzapine on Insulin Resistance in High Risk Prediabetics Completed NCT01411930 Phase 4 Intramuscular olanzapine, aripiprazole;Intramuscular aripiprazole, olanzapine
22 Physical Exercise Versus Rosiglitazone in CAD and Prediabetes Completed NCT00675740 Phase 4 rosiglitazone
23 Evaluation of the Translation of the DE-PLAN Program for the Primary Prevention of Type 2 Diabetes in Routine Primary Care Completed NCT01365013 Phase 4
24 The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes Completed NCT00546728 Phase 4 Exenatide;Metformin
25 Study to Determine the Effects of Human Growth Hormone and Pioglitazone in Overweight, Prediabetic Adults Completed NCT00352287 Phase 4 Recombinant human growth hormone; pioglitazone
26 Incretins in Impaired Fasting Glucose Completed NCT00364377 Phase 4 Sitagliptin
27 Mechanisms Underlying Metabolic Syndrome in Obesity Completed NCT00579813 Phase 4 Pioglitazone
28 The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion Completed NCT01056497 Phase 4 alpha lipoic acid
29 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
30 The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes Completed NCT01181986 Phase 4 Exenatide SC;Exenatide IV;Placebo SC;Exendin-9;Placebo IV
31 Effect of DPP4 Inhibition on Growth Hormone Secretion Completed NCT01701973 Phase 4 Sitagliptin;Pegvisomant;Placebo;L-NMMA;Exendin 9-39
32 Metformin in Insulin Resistant Left Ventricular (LV) Dysfunction (TAYSIDE Trial) Completed NCT00473876 Phase 4 Metformin;Matched Placebo (Capsules)
33 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
34 Niacin, N-3 Fatty Acids and Insulin Resistance Completed NCT00286234 Phase 4 omega-3 acid ethyl esters;extended release niacin;placebo;omega-3 acid ethyl esters;combined treatment
35 Metformin in Longevity Study (MILES). Completed NCT02432287 Phase 4 Metformin;Placebo
36 Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM Completed NCT01856907 Phase 4 Sitagliptin-Metformin;Metformin;Placebo pill
37 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
38 MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease Completed NCT02226510 Phase 4 Metformin XL;Placebo
39 Satisfaction of Treatment Among Elderly Patients With Insulin Therapy Completed NCT01240200 Phase 4 Glargine
40 Sitagliptin Therapy in Hospitalized Patients With Type 2 Diabetes Completed NCT01845831 Phase 4 Sitagliptin;Basal Bolus;Metformin and Sitagliptin;Glargine;Glargine 50%;Glargine 80%
41 Coronary Artery Disease Progression in Patients With Prediabetes Recruiting NCT02744976 Phase 4 Metformin
42 Improving Beta Cell Function in Mexican American Women With Prediabetes Recruiting NCT02488057 Phase 4 Liraglutide
43 China Protection Trial of Glucose Metabolism by Pitavastatin in Patients With Prediabetes and Hypertension Recruiting NCT03532620 Phase 4 Pitavastatin Calcium;Atorvastatin Calcium
44 Efficacy of Metformin in Preventing Diabetes in China Recruiting NCT03441750 Phase 4 metformin
45 Hospital-based Diabetes Prevention Study in Korea Recruiting NCT02981121 Phase 4 Metformin
46 Cardiovascular Effects of GLP-1 Receptor Activation Recruiting NCT03101930 Phase 4 Liraglutide;Sitagliptin;Placebos;Exendin (9-39)
47 Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling Recruiting NCT02437084 Phase 4 Atorvastatin
48 High-Dose Statin Combined With Telmisartan vs Amlodipine on Glucose Metabolism in ASCVD Patients With IFG and Hypertension Recruiting NCT03474562 Phase 4 Duowell®;Monorova® + Amlopin®
49 Saxenda in Obesity Services (STRIVE Study) Recruiting NCT03036800 Phase 4 Saxenda
50 A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men ( TRAVERSE ) Recruiting NCT03518034 Phase 4 Testosterone;Placebo

Search NIH Clinical Center for Prediabetes Syndrome

Cochrane evidence based reviews: prediabetic state

Sources

Genetic Tests for Prediabetes Syndrome

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Sources

Anatomical Context for Prediabetes Syndrome

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MalaCards organs/tissues related to Prediabetes Syndrome:

41
Testes, Heart, Kidney, Liver, Skin, Brain, Bone
Sources

Publications for Prediabetes Syndrome

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Articles related to Prediabetes Syndrome:

(show all 39)
# Title Authors Year
1
Sympathetic and baroreflex abnormalities in the uncomplicated prediabetic state. ( 29300244 )
2018
2
Influence of Health Behaviors and Occupational Stress on Prediabetic State among Male Office Workers. ( 29904033 )
2018
3
Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. ( 28007053 )
2017
4
Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice. ( 28559285 )
2017
5
Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. ( 25961052 )
2015
6
Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultraperformance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry. ( 20557141 )
2010
7
Bullosis diabeticorum associated with a prediabetic state. ( 19434030 )
2009
8
Postprandial hyperglycemia after a gastrectomy and the prediabetic state: a comparison between a distal and total gastrectomy. ( 18668310 )
2008
9
Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats. ( 17608620 )
2007
10
Insulin resistance, inflammation, and the prediabetic state. ( 12957323 )
2003
11
Inflammation in the prediabetic state is related to increased insulin resistance rather than decreased insulin secretion. ( 14517163 )
2003
12
Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. ( 10704163 )
2000
13
Postpartum oral glucose tolerance tests in mothers of macarosomic infants: inadequacy of current antenatal test criteria in detecting prediabetic state. ( 10471139 )
1999
14
Type 1 diabetes and prediabetic state in a monozygotic triplet. ( 10916559 )
1998
15
Characterization of the prediabetic state. ( 9324118 )
1997
16
Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study. ( 8243847 )
1993
17
Delayed menarche as an indicator of a prediabetic state. ( 7239049 )
1981
18
Dietetic therapy of prediabetic state. ( 865858 )
1977
19
Pharmacologic treatment of the prediabetic state. ( 865859 )
1977
20
The prediabetic state, its nature and consequences--a look toward the future. ( 5054335 )
1972
21
Electron microscopic study of the beta cells of the islets of Langerhans in rats under an experimentally-induced prediabetic state. ( 4893517 )
1969
22
Microangiopathy within the gingival tissues of diabetic subjects with special reference to the prediabetic state. ( 5228309 )
1967
23
Hyperglycemia after gastrectomy as a prediabetic state. Clinical study of 100 postgastrectomy patients. ( 6026709 )
1967
24
The remote prediabetic state. Effect on infant size, fetal and perinatal mortality. ( 5950497 )
1966
25
PREDIABETIC STATE IN ISCHEMIC HEART DISEASE. ( 14285473 )
1965
26
THE PREDIABETIC STATE. ( 14114984 )
1964
27
A study of pregnancy in relation to the prediabetic state. ( 13994740 )
1963
28
Studies on the prediabetic state. ( 13859737 )
1962
29
The prediabetic state: a concept of dynamic resistance to a genetic diabetogenic influence. ( 13880870 )
1962
30
Prediabetic state. ( 13926259 )
1962
31
The prediabetic state. A concept of dynamic resistance to a genetic diabetogenic influence. ( 13880869 )
1961
32
The prediabetic state. ( 13787950 )
1960
33
Diabetes mellitus or the prediabetic state in the mother and the neonate. ( 13828237 )
1959
34
Pregnancy and the prediabetic state. ( 13844741 )
1959
35
Unsuspected prediabetic state and pregnancy. ( 13559332 )
1958
36
The prediabetic state in man; definition, interpretation and implications. ( 13574021 )
1958
37
Evaluation of the prediabetic state during pregnancy. ( 13431126 )
1957
38
Diabetes and pregnancy: with special reference to the prediabetic state. ( 14811291 )
1951
39
The prediabetic state and its clinical importance. ( 15436964 )
1950
Sources

Variations for Prediabetes Syndrome

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Expression for Prediabetes Syndrome

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Search GEO for disease gene expression data for Prediabetes Syndrome.
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Pathways for Prediabetes Syndrome

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Pathways related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Glucose / Energy Metabolism 4
12.29 ADIPOQ GAD1 GCG INS PPARG
2
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.19 ADIPOQ INS LEP PPARG
4
Selenium Micronutrient Network 1
Show member pathways
 12.05 ALB APOB CRP IL6 INS
5
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.81 ALB IL6 INS
6
Adipogenesis 1
11.67 ADIPOQ IL6 INS LEP PPARG
7
Peptide hormone metabolism 66
Show member pathways
 11.36 DPP4 GCG INS LEP SLC30A8 TCF7L2
8
Incretin synthesis, secretion, and inactivation 66
Show member pathways
 11.31 DPP4 GCG LEP TCF7L2
9
FOXA1 transcription factor network 1
Show member pathways
 11.27 APOB GCG INS
10
Differentiation of white and brown adipocyte 1
10.94 ADIPOQ LEP PPARG
11
Overview of nanoparticle effects 1
10.77 CRP IL6
12
Transcription factor regulation in adipogenesis 1
10.6 ADIPOQ IL6 LEP PPARG
Sources

GO Terms for Prediabetes Syndrome

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Cellular components related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ADIPOQ ALB APOB CRP GCG IL6
2 endoplasmic reticulum lumen GO:0005788 9.55 ALB APOB GCG IL6 INS
3 extracellular region GO:0005576 9.32 ADIPOQ ALB APOB CRP DPP4 GCG
4 endosome lumen GO:0031904 9.26 APOB INS

Biological processes related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.77 IL6 INS LEP
2 regulation of signaling receptor activity GO:0010469 9.77 ADIPOQ GCG IL6 INS LEP
3 cellular protein metabolic process GO:0044267 9.73 ALB APOB IL6 INS
4 response to nutrient GO:0007584 9.7 ADIPOQ LEP PPARG
5 response to glucose GO:0009749 9.67 ADIPOQ SLC30A8 TCF7L2
6 regulation of insulin secretion GO:0050796 9.65 DPP4 GCG LEP
7 negative regulation of collagen biosynthetic process GO:0032966 9.59 IL6 PPARG
8 positive regulation of cellular protein metabolic process GO:0032270 9.58 ADIPOQ INS
9 positive regulation of insulin receptor signaling pathway GO:0046628 9.58 INS LEP
10 glucose metabolic process GO:0006006 9.58 ADIPOQ INS LEP
11 regulation of fat cell differentiation GO:0045598 9.57 LEP PPARG
12 fatty acid oxidation GO:0019395 9.56 ADIPOQ PPARG
13 negative regulation of gluconeogenesis GO:0045721 9.55 ADIPOQ INS
14 locomotory exploration behavior GO:0035641 9.54 DPP4 GAD1
15 negative regulation of blood vessel diameter GO:0097756 9.51 CRP INS
16 negative regulation of acute inflammatory response GO:0002674 9.46 INS PPARG
17 acute-phase response GO:0006953 9.43 CRP IL6 INS
18 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.33 ADIPOQ CRP PPARG
19 cellular response to prostaglandin stimulus GO:0071379 9.32 APOB PPARG
20 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 LEP
21 glucose homeostasis GO:0042593 9.1 ADIPOQ INS LEP PPARG SLC30A8 TCF7L2

Molecular functions related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ADIPOQ ALB CRP DPP4 GCG INS
2 low-density lipoprotein particle receptor binding GO:0050750 9.16 APOB CRP
3 hormone activity GO:0005179 8.92 ADIPOQ GCG INS LEP
Sources

Sources for Prediabetes Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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