MCID: PRD001
MIFTS: 30

Predominantly Cortical Thymoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Predominantly Cortical Thymoma

MalaCards integrated aliases for Predominantly Cortical Thymoma:

Name: Predominantly Cortical Thymoma 12 15
Lymphocyte-Predominant Thymoma 12
Thymoma, Organoid 12
Thymoma, Type B1 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6917
NCIt 50 C6887
UMLS 73 C1266094

Summaries for Predominantly Cortical Thymoma

MalaCards based summary : Predominantly Cortical Thymoma, also known as lymphocyte-predominant thymoma, is related to sweat gland disease and myoepithelioma. An important gene associated with Predominantly Cortical Thymoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Keratinization and Circadian entrainment. Affiliated tissues include lung, bone and ovary, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Predominantly Cortical Thymoma

Diseases related to Predominantly Cortical Thymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 sweat gland disease 10.1 KRT14 PGR
2 myoepithelioma 10.1 KRT14 PTPRC
3 embryoma 10.1 KRT14 KRT19
4 odontoma 10.1 KRT14 KRT19
5 vestibular gland benign neoplasm 10.1 ESR1 PGR
6 bartholin's gland adenoma 10.1 ESR1 PGR
7 limbal stem cell deficiency 10.1 KRT14 KRT19
8 vulvar syringoma 10.1 ESR1 PGR
9 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
10 lipoadenoma 10.1 KRT14 KRT19
11 lung leiomyoma 10.1 ESR1 PGR
12 leiomyoma 10.1 ESR1 PGR
13 myoma 10.1 ESR1 PGR
14 vulvar benign neoplasm 10.1 ESR1 PGR
15 trigonitis 10.1 ESR1 PGR
16 vulvar leiomyoma 10.1 ESR1 PGR
17 breast medullary carcinoma 10.1 ESR1 PGR
18 pregnancy adenoma 10.1 KRT14 KRT19
19 breast scirrhous carcinoma 10.1 ESR1 PGR
20 spindle cell carcinoma 10.1 KRT14 PGR
21 bartholin's gland benign neoplasm 10.1 ESR1 PGR
22 progesterone-receptor positive breast cancer 10.1 ESR1 PGR
23 progesterone resistance 10.1 ESR1 PGR
24 endometrial squamous cell carcinoma 10.1 ESR1 PGR
25 epidural neoplasm 10.1 KRT19 PTPRC
26 cribriform carcinoma 10.1 ESR1 PGR
27 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
28 adenoid basal cell carcinoma 10.1 ESR1 PGR
29 breast adenoid cystic carcinoma 10.1 ESR1 PGR
30 apocrine adenocarcinoma 10.1 ESR1 PGR
31 peritoneal benign neoplasm 10.1 ESR1 PGR
32 gender identity disorder 10.1 ESR1 PGR
33 deep angioma 10.1 ESR1 PGR
34 diffuse peritoneal leiomyomatosis 10.1 ESR1 PGR
35 leiomyomatosis 10.1 ESR1 PGR
36 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
37 intraneural perineurioma 10.1 KRT14 KRT19
38 corneal abscess 10.1 KRT19 PGR
39 thymus lipoma 10.1 KRT19 PTPRC
40 female reproductive endometrioid cancer 10.1 ESR1 PGR
41 cervical carcinosarcoma 10.1 ESR1 PGR
42 pinguecula 10.1 KRT14 KRT19
43 estrogen excess 10.1 ESR1 PGR
44 immune system organ benign neoplasm 10.1 KRT19 PTPRC
45 intramuscular hemangioma 10.1 ESR1 PGR
46 glycogen-rich clear cell breast carcinoma 10.1 ESR1 PGR
47 mammographic density 10.1 ESR1 PGR
48 retinitis pigmentosa 47 10.1 ESR1 PGR
49 white sponge nevus 1 10.1 KRT14 KRT19
50 inflammatory breast carcinoma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Predominantly Cortical Thymoma:



Diseases related to Predominantly Cortical Thymoma

Symptoms & Phenotypes for Predominantly Cortical Thymoma

MGI Mouse Phenotypes related to Predominantly Cortical Thymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.77 ESR1 KRT14 KRT19 PDPN PTPRC
2 endocrine/exocrine gland MP:0005379 9.72 ESR1 KRT14 KRT19 PGR PTPRC
3 integument MP:0010771 9.65 ESR1 KRT14 KRT19 PDPN PGR
4 neoplasm MP:0002006 9.55 ESR1 KRT14 KRT19 PGR PTPRC
5 no phenotypic analysis MP:0003012 9.26 ESR1 KRT19 PGR PTPRC
6 skeleton MP:0005390 9.02 ESR1 KRT19 PDPN PGR PTPRC

Drugs & Therapeutics for Predominantly Cortical Thymoma

Search Clinical Trials , NIH Clinical Center for Predominantly Cortical Thymoma

Genetic Tests for Predominantly Cortical Thymoma

Anatomical Context for Predominantly Cortical Thymoma

MalaCards organs/tissues related to Predominantly Cortical Thymoma:

41
Lung, Bone, Ovary, Prostate, Cervix, Smooth Muscle, Thymus

Publications for Predominantly Cortical Thymoma

Articles related to Predominantly Cortical Thymoma:

# Title Authors Year
1
Thymoma type B1 arising in a giant supradiaphragmatic thymolipoma. ( 24887884 )
2014

Variations for Predominantly Cortical Thymoma

Expression for Predominantly Cortical Thymoma

Search GEO for disease gene expression data for Predominantly Cortical Thymoma.

Pathways for Predominantly Cortical Thymoma

Pathways related to Predominantly Cortical Thymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 IVL KRT14 KRT19
2
Show member pathways
11.79 ESR1 KRT14 KRT19 PGR
3 10.5 ESR1 KRT19

GO Terms for Predominantly Cortical Thymoma

Cellular components related to Predominantly Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.8 KRT14 KRT19 PTPRC

Biological processes related to Predominantly Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to estrogen GO:0043627 9.26 ESR1 KRT19
2 steroid hormone mediated signaling pathway GO:0043401 9.16 ESR1 PGR
3 keratinization GO:0031424 9.13 IVL KRT14 KRT19
4 cornification GO:0070268 8.8 IVL KRT14 KRT19

Molecular functions related to Predominantly Cortical Thymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.26 ESR1 PGR
2 steroid hormone receptor activity GO:0003707 9.16 ESR1 PGR
3 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
4 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Predominantly Cortical Thymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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