PEE1
MCID: PRC031
MIFTS: 41

Preeclampsia/eclampsia 1 (PEE1)

Categories: Blood diseases, Genetic diseases
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Aliases & Classifications for Preeclampsia/eclampsia 1

MalaCards integrated aliases for Preeclampsia/eclampsia 1:

Name: Preeclampsia/eclampsia 1 57 28 12
Preeclampsia/eclampsia, Type 1 38
Toxemia of Pregnancy 57
Pregnancy Toxemias 53
Pre-Eclampsia 71
Preg1 57
Pee1 57
Pee 57

Characteristics:


Inheritance:

Autosomal dominant 57

OMIM®:

57 (Updated 08-Dec-2022)
Miscellaneous:
majority of cases are sporadic
occurs in ~3% pregnancies in western populations
clinical manifestation ranges from mild, transient hypertension to hellp syndrome (hemolysis, elevated liver enzymes, and low platelets)


Classifications:



Summaries for Preeclampsia/eclampsia 1

OMIM®: 57 Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide (summary by Payne et al., 2011). Preeclampsia is otherwise known as gestational proteinuric hypertension (Davey and MacGillivray, 1988). A high proportion of patients with preeclampsia have glomerular endotheliosis, the unique histopathologic feature of the condition (Fisher et al., 1981). A distinct form of severe preeclampsia is characterized by hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome) (Brown et al., 2000). (189800) (Updated 08-Dec-2022)

MalaCards based summary: Preeclampsia/eclampsia 1, also known as preeclampsia/eclampsia, type 1, is related to eclampsia and pre-eclampsia, and has symptoms including edema and hyperemesis gravidarum. An important gene associated with Preeclampsia/eclampsia 1 is NOS3 (Nitric Oxide Synthase 3). The drugs Azithromycin and Magnesium sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and placenta, and related phenotypes are seizure and hypertension

Related Diseases for Preeclampsia/eclampsia 1

Diseases in the Preeclampsia/eclampsia 1 family:

Preeclampsia/eclampsia 2 Preeclampsia/eclampsia 3
Preeclampsia/eclampsia 4 Preeclampsia/eclampsia 5

Diseases related to Preeclampsia/eclampsia 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 eclampsia 30.9 SERPINC1 PEE1 NOS3
2 pre-eclampsia 30.9 SERPINC1 PEE1 NOS3
3 buerger disease 29.6 SERPINC1 NOS3
4 pulmonary edema 29.5 SERPINC1 NOS3
5 stroke, ischemic 29.2 SERPINC1 NOS3
6 preeclampsia/eclampsia 5 11.0
7 ovarian cancer 11.0
8 thrombotic thrombocytopenic purpura 11.0
9 adrenal gland disease 11.0
10 retinal detachment 10.4
11 hypertension, essential 10.3
12 disseminated intravascular coagulation 10.3
13 hydatidiform mole, recurrent, 1 10.3
14 severe pre-eclampsia 10.3
15 gestational trophoblastic neoplasm 10.3
16 hypertensive retinopathy 10.2
17 placental abruption 10.2
18 pain agnosia 10.1
19 hypoadrenocorticism, familial 10.1
20 mild pre-eclampsia 10.1
21 pyelonephritis 10.1
22 thrombocytopenia 10.1
23 retinal vascular occlusion 10.1
24 retinal vascular disease 10.1
25 glomerulonephritis 10.1
26 purpura 10.1
27 urinary tract infection 10.1
28 chlamydia 10.1
29 encephalopathy 10.1
30 coloboma of optic nerve 10.0
31 hepatic encephalopathy 10.0
32 interstitial cystitis 10.0
33 cystitis 10.0
34 liver disease 10.0
35 irritable bowel syndrome 10.0
36 endocardial fibroelastosis 10.0
37 histidinemia 10.0
38 prothrombin deficiency, congenital 10.0
39 prothrombin thrombophilia 10.0
40 fetal erythroblastosis 10.0
41 respiratory failure 10.0
42 visual epilepsy 10.0
43 pemphigoid gestationis 10.0
44 prothrombin deficiency 10.0
45 anuria 10.0
46 hypertriglyceridemia 1 10.0
47 pheochromocytoma 10.0
48 thrombocytopenic purpura, autoimmune 10.0
49 thrombophilia due to thrombin defect 10.0
50 volvulus of midgut 10.0

Graphical network of the top 20 diseases related to Preeclampsia/eclampsia 1:



Diseases related to Preeclampsia/eclampsia 1

Symptoms & Phenotypes for Preeclampsia/eclampsia 1

Human phenotypes related to Preeclampsia/eclampsia 1:

30 (show all 10)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizure 30 HP:0001250
2 hypertension 30 HP:0000822
3 proteinuria 30 HP:0000093
4 intrauterine growth retardation 30 HP:0001511
5 elevated hepatic transaminase 30 HP:0002910
6 thrombocytopenia 30 HP:0001873
7 edema 30 HP:0000969
8 preeclampsia 30 HP:0100602
9 eclampsia 30 HP:0100601
10 maternal hypertension 30 HP:0008071

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Genitourinary Kidneys:
proteinuria

Muscle Soft Tissue:
edema

Cardiovascular Vascular:
maternal hypertension (after 20th week gestation, resolved postpartum)

Abdomen Liver:
elevated liver enzymes

Hematology:
thrombocytopenia (hellp syndrome)

Laboratory Abnormalities:
proteinuria
elevated liver enzymes

Growth Other:
intrauterine growth retardation (in fetus)

Prenatal Manifestations Maternal:
maternal hypertension (after 20th week gestation, resolved postpartum)

Neurologic Central Nervous System:
seizures (eclampsia)

Clinical features from OMIM®:

189800 (Updated 08-Dec-2022)

UMLS symptoms related to Preeclampsia/eclampsia 1:


edema; hyperemesis gravidarum

Drugs & Therapeutics for Preeclampsia/eclampsia 1

Drugs for Preeclampsia/eclampsia 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 277)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043
2
Magnesium sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9
3
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
4
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
5
Nitric Oxide Approved Phase 4 10102-43-9 145068
6
Enalaprilat Approved Phase 4 76420-72-9 6917719 5462501
7
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5388962 5362032
8
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
9
Isosorbide dinitrate Approved, Investigational Phase 4 87-33-2 3780 6883
10
Isosorbide Approved, Investigational Phase 4 652-67-5 99937 12597
11
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
12
Clonidine Approved Phase 4 4205-91-8, 4205-90-7 2803 20179
13
Captopril Approved Phase 4 62571-86-2 44093
14
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
15
Metformin Approved Phase 4 1115-70-4, 657-24-9 4091
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
18
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
19
Labetalol Approved Phase 4 36894-69-6 3869
20
Nifedipine Approved Phase 4 21829-25-4 4485
21
Ibuprofen Approved Phase 4 15687-27-1 3672
22
Metamizole Approved, Investigational, Withdrawn Phase 4 50567-35-6 3111 522325
23
Racephedrine Approved, Experimental Phase 4 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
24
Phenylephrine Approved Phase 4 59-42-7 6041
25
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
26
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
27
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
28 Vitamins Phase 4
29 Calciferol Phase 4
30 Trace Elements Phase 4
31 Micronutrients Phase 4
32
Vitamin D2 Phase 4 3249
33 Ergocalciferols Phase 4
34 Anti-Bacterial Agents Phase 4
35 Anti-Arrhythmia Agents Phase 4
36 Sympatholytics Phase 4
37 Estrogens Phase 4
38 Sodium Potassium Chloride Symporter Inhibitors Phase 4
39 Pharmaceutical Solutions Phase 4
40 Hormone Antagonists Phase 4
41 Estrogen Receptor Antagonists Phase 4
42 Estrogen Antagonists Phase 4
43 17 alpha-Hydroxyprogesterone Caproate Phase 4
44 11-hydroxyprogesterone Phase 4
45 Caproate Phase 4
46 Progestins Phase 4
47 Isosorbide-5-mononitrate Phase 4
48 Sodium Channel Blockers Phase 4
49 Anesthetics, Local Phase 4
50 Diuretics, Potassium Sparing Phase 4

Interventional clinical trials:

(show top 50) (show all 623)
# Name Status NCT ID Phase Drugs
1 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
2 Low Dose Calcium Supplementation to Prevent Preeclampsia: a Cluster Randomized Study Unknown status NCT02338687 Phase 4
3 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Unknown status NCT03233880 Phase 4 Azithromycin 1gm
4 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Unknown status NCT02911701 Phase 4 Acetaminophen;Ibuprofen
5 Effectiveness Of Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia: Randomized Placebo-Controlled Clinical Trial Unknown status NCT01361425 Phase 4 methildopa;placebo
6 Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Unknown status NCT03318211 Phase 4 Magnesium Sulfate
7 A Prospective Muti-center Study of Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort Unknown status NCT04631627 Phase 4 Aspirin
8 Effect of Administering Intravenous Magnesium Sulfate Heptahydrate (MgSO4•7H2O) on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients in 3rd Trimester of Pregnancy Unknown status NCT03237000 Phase 4 MgSO4
9 Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial Unknown status NCT04051567 Phase 4 Aspirin 100mg
10 Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial) Unknown status NCT00117546 Phase 4 alpha methyldopa
11 Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension Unknown status NCT03449277 Phase 4 Oral Tablet
12 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Unknown status NCT02920593 Phase 4 Vitamin D3
13 An Open-label Randomized-Controlled Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
14 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
15 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
16 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
17 A Randomized-controlled Trial to Assess the Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed NCT02891174 Phase 4 Ibuprofen;Acetaminophen
18 Efficacy and Safety of One Gram Versus Two Grams Intravenous Maintenance Dose of Magnesium Sulfate in Women With Severe Pre-eclampsia: a Randomized Clinical Trial. Completed NCT03164304 Phase 4 Magnesium Sulfate
19 Adding Magnesium Sulphate to Epidural Levobupivacaine in Elective Caesarian Section for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
20 A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Serum Concentrations Obtained in the Treatment of Severe Preeclampsia With a Repeat Bolus Intravenous Magnesium Sulfate Regimen Administered With the Springfusor Infusion Pump to a Continuous Intravenous Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
21 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Completed NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
22 A Randomized Controlled Trial Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period Completed NCT04236258 Phase 4 NIFEdipine ER;Enalapril
23 Efficacy of 17-Hydroxyprogesterone Caproate in Expectantly Managed Early-onset Preeclampsia: A Randomized Controlled Study Completed NCT04077853 Phase 4 17 Hydroxyprogesterone Capronate
24 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
25 Randomized Controlled Trial of Nitric-oxide Donor (NOD) Isosorbide Mononitrate (IMN) Versus Placebo for Induction of Labor in Pregnancies Complicated by Preeclampsia Completed NCT03171480 Phase 4 Monoket Pill;Placebo
26 Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women With Severe Preeclampsia: a Randomized Clinical Trial Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
27 Comparison Between Different Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Ceaserian Section for Patients With Preeclampsia Completed NCT05368415 Phase 4 Norepinephrine
28 Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
29 Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients Completed NCT03506724 Phase 4 Nifedipine;Labetalol
30 Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsia: a Randomized Clinical Trial Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
31 Randomized Trial of Magnesium Sulfate in Obese Preeclamptic Women Completed NCT02835339 Phase 4 Magnesium sulfate 4g loading dose, 1g/hr infusion;Magnesium sulfate 6g loading dose, 2g/hr infusion
32 Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension: A Pilot Study Recruiting NCT04908982 Phase 4 Aspirin 81mg
33 Personalized Hemodynamically Guided Antihypertensive Treatment in Pregnant Women With Mild to Moderate Hypertension: a Randomized Controlled Trial Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
34 Lignocaine Nebulization for Attenuation of Intubation Stress Response in Patients With Severe Pre-eclampsia: a Prospective Double-blinded Placebo-controlled Trial Recruiting NCT04441073 Phase 4 Lignocaine;Placebo
35 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
36 The Effect of 81mg vs 162mg ASA for Preeclampsia Prevention in Obese Women at High Risk for Developing Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
37 162 mg of Aspirin for Prevention of Preeclampsia Recruiting NCT05221164 Phase 4 Aspirin 162 mg
38 Aspirin to Prevent Cardiac Dysfunction in Preeclampsia Recruiting NCT04479072 Phase 4 Aspirin 81 mg;Placebo
39 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Recruiting NCT03570632 Phase 4 Metformin
40 Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia Recruiting NCT04797949 Phase 4 Low-dose aspirin
41 Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension: A Comparative Effectiveness Pilot Randomized Controlled Trial Active, not recruiting NCT05049616 Phase 4 ACE Inhibitors and Diuretics;NIFEdipine ER
42 Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor Active, not recruiting NCT04392375 Phase 4 Nifedipine 30 MG;Placebos
43 The Effectiveness of Low-dose Aspirin on Preventing Pre-eclampsia in High-risks Pregnant Women Not yet recruiting NCT04656665 Phase 4 Aspirin
44 A Prospective Randomized Clinical Research Trial Comparing the Incidence of Preeclampsia Between Pregnant Women Receiving Tdap Vaccinations at Week 28 and Those Receiving Tdap Vaccinations at Week 36 Not yet recruiting NCT04424693 Phase 4 Tdap Vaccine Administration
45 Blood Levels of Co-inhibitory Receptors (TIM-3,LAG-3 and TIGIT)in Preeclampsia Patients Not yet recruiting NCT05294952 Phase 4
46 A Prospective Interventional Randomized Controlled Trial to Assess the Effect of Low Dose Acetylsalicylic Acid as a Preventive Treatment of Pre-eclampsia in Pregnant Women Who Underwent Frozen Embryo Transfer Not yet recruiting NCT05460416 Phase 4 Acetylsalicylic acid
47 Use of Ibuprofen Versus Dipyrone in Preeclampsia Submitted to C-section: Randomized Clinical Trial Not yet recruiting NCT05586373 Phase 4 medication 1;medication 2
48 Oral Nifedipine Versus Intravenous Labetalol for Postpartum (PP) Hypertensive Emergency: A Randomized Clinical Trial (RCT) Not yet recruiting NCT05139238 Phase 4 Labetalol;Nifedipine
49 Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial Not yet recruiting NCT05309460 Phase 4 Labetalol Oral Tablet;NIFEdipine ER
50 Impact of Vasopressor Administration on Maternal and Neonatal Outcomes in Women With Pre-eclampsia Terminated NCT02025426 Phase 4 Phenylephrine;Ephedrine

Search NIH Clinical Center for Preeclampsia/eclampsia 1

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Magnesium Sulfate

Genetic Tests for Preeclampsia/eclampsia 1

Genetic tests related to Preeclampsia/eclampsia 1:

# Genetic test Affiliating Genes
1 Preeclampsia/eclampsia 1 28 NOS3

Anatomical Context for Preeclampsia/eclampsia 1

Organs/tissues related to Preeclampsia/eclampsia 1:

MalaCards : Liver, Endothelial, Placenta, Whole Blood, Brain, Lung, Kidney

Publications for Preeclampsia/eclampsia 1

Articles related to Preeclampsia/eclampsia 1:

(show top 50) (show all 1526)
# Title Authors PMID Year
1
A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. 62 57
11035632 2000
2
The familial factor in toxemia of pregnancy. 62 57
5742111 1968
3
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. 57
28628106 2017
4
Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia. 57
25143393 2015
5
HELLP babies link a novel lincRNA to the trophoblast cell cycle. 57
23093777 2012
6
Assessment, surveillance and prognosis in pre-eclampsia. 57
21459048 2011
7
Pre-eclampsia: pathophysiology, diagnosis, and management. 57
21822394 2011
8
Familial aggregation of preeclampsia and intrauterine growth restriction in a genetically isolated population in The Netherlands. 57
18612323 2008
9
Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. 57
18660815 2008
10
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. 57
18469803 2008
11
Extremely skewed X-chromosome inactivation is increased in pre-eclampsia. 57
17115188 2007
12
Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. 57
15889386 2005
13
The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. 57
16059745 2005
14
Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study. 57
15384082 2004
15
Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. 57
15477349 2004
16
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. 57
14673478 2004
17
Circulating angiogenic factors and the risk of preeclampsia. 57
14764923 2004
18
The genetics of pre-eclampsia: a feto-placental or maternal problem? 57
12859402 2003
19
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. 57
12618519 2003
20
Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia. 57
12173035 2002
21
Paternal contribution to the risk for pre-eclampsia. 57
11826024 2002
22
A genome-wide scan for preeclampsia in the Netherlands. 57
11781687 2001
23
A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. 57
11283205 2001
24
Risk factors for preeclampsia. 57
11259727 2001
25
Paternal and maternal components of the predisposition to preeclampsia. 57
11259719 2001
26
Pathogenesis and genetics of pre-eclampsia. 57
11197372 2001
27
Expression and relationship between endothelin-1 messenger ribonucleic acid (mRNA) and inducible/endothelial nitric oxide synthase mRNA isoforms from normal and preeclamptic placentas. 57
10852470 2000
28
Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. 57
10866201 2000
29
The detection, investigation and management of hypertension in pregnancy: full consensus statement. 57
10925900 2000
30
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. 57
10655155 2000
31
Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies. 57
10576196 1999
32
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. 57
10441346 1999
33
Twin mothers, pregnancy hypertension and pre-eclampsia. 57
10426615 1999
34
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. 57
10194466 1999
35
Increased frequency of genetic thrombophilia in women with complications of pregnancy. 57
9878639 1999
36
Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism. 57
9459326 1998
37
Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. 57
9311740 1997
38
Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. 57
9192280 1997
39
A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. 57
9150163 1997
40
HELLP syndrome associated with factor V R506Q mutation. 57
8616100 1996
41
Concerns about the genetics of pre-eclampsia. 57
8488831 1993
42
An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance. 57
1550119 1992
43
Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus? 57
1760418 1991
44
Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta. 57
1975853 1990
45
Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. 57
2242360 1990
46
Association between susceptibility to pre-eclampsia within families and HLA DR4. 57
2572795 1989
47
Genetics of pre-eclampsia. 57
2901618 1988
48
Genetic control of susceptibility to eclampsia and miscarriage. 57
3415930 1988
49
The classification and definition of the hypertensive disorders of pregnancy. 57
3364501 1988
50
Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. 57
3768285 1986

Variations for Preeclampsia/eclampsia 1

Expression for Preeclampsia/eclampsia 1

Search GEO for disease gene expression data for Preeclampsia/eclampsia 1.

Pathways for Preeclampsia/eclampsia 1

GO Terms for Preeclampsia/eclampsia 1

Sources for Preeclampsia/eclampsia 1

2 CDC
6 CNVD
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9 dbSNP
10 DGIdb
16 EFO
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18 FMA
19 GARD
27 GO
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29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
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43 MeSH
44 MESH via Orphanet
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48 NCI
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55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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