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PEE
MCID: PRC031
MIFTS: 41

Preeclampsia/eclampsia 1 (PEE)

Categories: Blood diseases, Genetic diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Preeclampsia/eclampsia 1

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MalaCards integrated aliases for Preeclampsia/eclampsia 1:

Name: Preeclampsia/eclampsia 1 58 13
Preeclampsia/eclampsia, Type 1 41
Toxemia of Pregnancy 58
Pre-Eclampsia 74
Preg1 58
Pee1 58
Pee 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
majority of cases are sporadic
occurs in ~3% pregnancies in western populations
clinical manifestation ranges from mild, transient hypertension to hellp syndrome (hemolysis, elevated liver enzymes, and low platelets)


HPO:

33
preeclampsia/eclampsia 1:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Preeclampsia/eclampsia 1

About this section
OMIM : 58 Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide (summary by Payne et al., 2011). Preeclampsia is otherwise known as gestational proteinuric hypertension (Davey and MacGillivray, 1988). A high proportion of patients with preeclampsia have glomerular endotheliosis, the unique histopathologic feature of the condition (Fisher et al., 1981). A distinct form of severe preeclampsia is characterized by hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome) (Brown et al., 2000). (189800)

MalaCards based summary : Preeclampsia/eclampsia 1, also known as preeclampsia/eclampsia, type 1, is related to pre-eclampsia and eclampsia, and has symptoms including edema and hyperemesis gravidarum. An important gene associated with Preeclampsia/eclampsia 1 is NSD1 (Nuclear Receptor Binding SET Domain Protein 1). The drugs Methyldopa and Calcium Carbonate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and testes, and related phenotypes are hypertension and seizures

Sources

Related Diseases for Preeclampsia/eclampsia 1

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Diseases in the Preeclampsia/eclampsia 5 family:

Preeclampsia/eclampsia 1 Preeclampsia/eclampsia 2
Preeclampsia/eclampsia 3 Preeclampsia/eclampsia 4

Diseases related to Preeclampsia/eclampsia 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 pre-eclampsia 11.3
2 eclampsia 11.2
3 thrombotic thrombocytopenic purpura 11.2
4 perrault syndrome 1 11.1
5 hepatic encephalopathy 10.2
6 encephalopathy 10.2
7 celiac disease 1 10.1
8 hydatidiform mole, recurrent, 1 10.0
9 cerebral hemorrhage 10.0
10 renal hypertension 10.0
11 anuria 10.0
12 purpura 10.0
13 gestational trophoblastic neoplasm 10.0
14 placental abruption 10.0
15 gestational trophoblastic tumor 10.0
16 retinal detachment 9.9
17 thrombocytopenic purpura, autoimmune 9.9
18 lymphatic malformation 7 9.9
19 diabetes mellitus 9.9
20 chronic pyelonephritis 9.9
21 disseminated intravascular coagulation 9.9
22 pyelonephritis 9.9
23 severe pre-eclampsia 9.9
24 hyperinsulinism 9.9
25 chorioangioma 9.9
26 exophthalmos 9.9
27 fetal edema 9.9
28 hydrops fetalis 9.9

Graphical network of the top 20 diseases related to Preeclampsia/eclampsia 1:



Diseases related to Preeclampsia/eclampsia 1
Sources

Symptoms & Phenotypes for Preeclampsia/eclampsia 1

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Human phenotypes related to Preeclampsia/eclampsia 1:

33 (show all 10)
# Description HPO Frequency HPO Source Accession
1 hypertension 33 HP:0000822
2 seizures 33 HP:0001250
3 proteinuria 33 HP:0000093
4 edema 33 HP:0000969
5 intrauterine growth retardation 33 HP:0001511
6 thrombocytopenia 33 HP:0001873
7 preeclampsia 33 HP:0100602
8 eclampsia 33 HP:0100601
9 maternal hypertension 33 HP:0008071
10 elevated hepatic transaminase 33 HP:0002910

Symptoms via clinical synopsis from OMIM:

58
Genitourinary Kidneys:
proteinuria

Muscle Soft Tissue:
edema

Cardiovascular Vascular:
maternal hypertension (after 20th week gestation, resolved postpartum)

Abdomen Liver:
elevated liver enzymes

Hematology:
thrombocytopenia (hellp syndrome)

Laboratory Abnormalities:
proteinuria
elevated liver enzymes

Growth Other:
intrauterine growth retardation (in fetus)

Prenatal Manifestations Maternal:
maternal hypertension (after 20th week gestation, resolved postpartum)

Neurologic Central Nervous System:
seizures (eclampsia)

Clinical features from OMIM:

189800

UMLS symptoms related to Preeclampsia/eclampsia 1:


edema, hyperemesis gravidarum
Sources

Drugs & Therapeutics for Preeclampsia/eclampsia 1

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Drugs for Preeclampsia/eclampsia 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 442)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4,Phase 2,Phase 1,Not Applicable 555-30-6 38853
2
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Not Applicable 471-34-1
3
Remifentanil Approved Phase 4,Phase 2,Phase 1 132875-61-7 60815
4
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68-04-2
5
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
6
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
7
Enoxaparin Approved Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772
8
Dalteparin Approved Phase 4,Phase 2,Phase 3,Early Phase 1 9005-49-6
9
leucovorin Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-05-9 6006 143
10
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 9005-49-6 772 46507594
11
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-56-6 439302 53477758
12
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 32051
13
Phenylephrine Approved Phase 4,Not Applicable 59-42-7 6041
14
Ephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 299-42-3 9294
15
Oxymetazoline Approved, Investigational Phase 4,Not Applicable 1491-59-4 4636
16
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 90-82-4 7028
17
Misoprostol Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 59122-46-2 5282381
18
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7487-88-9 24083
19
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
20
Furosemide Approved, Vet_approved Phase 4,Phase 2 54-31-9 3440
21
Clonidine Approved Phase 4,Phase 1,Phase 2,Not Applicable 4205-90-7 2803
22
Captopril Approved Phase 4 62571-86-2 44093
23
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
24
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Not Applicable 103-90-2 1983
25
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
26
Nifedipine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 21829-25-4 4485
27
Labetalol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 36894-69-6 3869
28
tannic acid Approved Phase 4,Phase 3,Not Applicable 1401-55-4
29
Benzocaine Approved, Investigational Phase 4,Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
30
Insulin Lispro Approved Phase 4,Not Applicable 133107-64-9
31
Insulin Aspart Approved Phase 4,Phase 3,Not Applicable 116094-23-6 16132418
32
Glyburide Approved Phase 4,Not Applicable 10238-21-8 3488
33
Azithromycin Approved Phase 4,Phase 3,Not Applicable 83905-01-5 55185 447043
34
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
35
Warfarin Approved Phase 4 81-81-2 6691 54678486
36
Insulin Detemir Approved Phase 4,Phase 3,Not Applicable 169148-63-4 5311023
37
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
38
Desogestrel Approved Phase 4 54024-22-5 40973
39
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-70-2 271
40
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
42
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 67-97-0 5280795 6221
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1406-16-2
44
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable 50-14-6 5280793
45
Serine Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1,Not Applicable 56-45-1 5951
46 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
49 Bone Density Conservation Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
50 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 766)
# Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Low Dose Calcium to Prevent Preeclampsia Unknown status NCT02338687 Phase 4
3 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4 alpha methyldopa
4 Remifentanil for General Anesthesia in Preeclamptics Unknown status NCT00567957 Phase 4 Remifentanil;Saline
5 Viagra for the Treatment of IUGR Unknown status NCT00347867 Phase 4 Viagra administration in IUGR/PET pregnancies
6 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
7 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
8 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
9 Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
10 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
11 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
12 Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
13 Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
14 A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
15 Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
16 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed NCT02891174 Phase 4 Ibuprofen;Acetaminophen
17 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
18 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Completed NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
19 Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women Completed NCT03528967 Phase 4 Enoxaparin 40 mg / 0.4 mL Prefilled Syringe;Aspirin 100 mg Oral Tablet, Enteric Coated
20 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
21 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT Completed NCT00790062 Phase 4 Oxytocin
22 Timing of Initiation of LMWH Administration in Pregnant Women With APS Completed NCT02326051 Phase 4 Enoxaparin;Enoxaparin
23 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
24 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
25 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
26 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women Completed NCT02377349 Phase 4 Saline placebo
27 The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
28 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
29 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
30 Phenylephrine Versus Ephedrine in Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
31 Acute Labetalol Use in Preeclampsia Recruiting NCT03872336 Phase 4 Experimental labetalol dose
32 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
33 Acute Control of Chronic Hypertension Recruiting NCT03877692 Phase 4 Experimental dosing of labetalol
34 Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension Recruiting NCT03449277 Phase 4 Oral Tablet
35 Response to Anti-hypertensives in Pregnant and Postpartum Patients Recruiting NCT03506724 Phase 4 Nifedipine;Labetalol
36 Postpartum NSAIDS and Maternal Hypertension Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
37 Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily? Recruiting NCT03595982 Phase 4 Procardia XL 30Mg;Procardia XL 60Mg
38 Chronotherapy With Low-dose Aspirin for Primary Prevention Recruiting NCT00725127 Phase 4 aspirin;aspirin
39 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
40 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
41 Use of Warfarin After the First Trimester in Pregnant Women With APS Recruiting NCT02303171 Phase 4 Enoxaparin;Warfarin
42 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4 Myo-inositol
43 Detemir Versus NPH for Type 2 Diabetes Mellitus in Pregnancy Recruiting NCT03620890 Phase 4 Neutral Protamine Hagedorn (NPH);Detemir insulin
44 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
45 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Active, not recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
46 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
47 Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Not yet recruiting NCT03318211 Phase 4 Magnesium Sulfate
48 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Not yet recruiting NCT03570632 Phase 4 Metformin
49 Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients Not yet recruiting NCT03237000 Phase 4 MgSO4
50 A Randomized Trial Comparing Oral Misoprostol Alone With Oral Misoprostol Followed by Oxytocin in Women Induced for Hypertension of Pregnancy Not yet recruiting NCT03749902 Phase 4 Oral misoprostol;Oxytocin

Search NIH Clinical Center for Preeclampsia/eclampsia 1

Inferred drug relations via UMLS 74 / NDF-RT 52 :
Sources

Genetic Tests for Preeclampsia/eclampsia 1

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Sources

Anatomical Context for Preeclampsia/eclampsia 1

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MalaCards organs/tissues related to Preeclampsia/eclampsia 1:

42
Endothelial, Liver, Testes, Placenta, Thyroid, Heart, Ovary
Sources

Publications for Preeclampsia/eclampsia 1

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Articles related to Preeclampsia/eclampsia 1:

(show all 30)
# Title Authors Year
1
A study of intravaginal misoprostol for induction of labor in toxemia of pregnancy. ( 11597613 )
2001
2
[Bilateral retinal detachment in toxemia of pregnancy]. ( 10526447 )
1999
3
[Changes in serum lipoprotein (a) levels related to hyperlipidemia during pregnancy--comparing normal pregnancy and toxemia of pregnancy]. ( 8721051 )
1996
4
Retinal pigment epithelium tear following toxemia of pregnancy. ( 7549444 )
1995
5
The relationship between clinical signs and hypercoagulable state in toxemia of pregnancy. ( 1828053 )
1991
6
[Blood coagulation and fibrinolytic studies in patients with toxemia of pregnancy]. ( 2273312 )
1990
7
Changes in placental atrial natriuretic peptide receptors associated with severe toxemia of pregnancy. ( 2543965 )
1989
8
Theory of the etiology of human toxemia of pregnancy: fetal hyperinsulinemia as a compensatory response to decreased uterine blood flow. ( 3302629 )
1987
9
HLA antigens-antibodies system and its association with severe toxemia of pregnancy. ( 3973430 )
1985
10
[Ultrastructural and ultracytochemical characteristics of the terminal villi of the placenta in EPH-toxemia of pregnancy]. ( 3006644 )
1985
11
Thrombotic thrombocytopenic purpura mimicking toxemia of pregnancy. ( 6541433 )
1984
12
The role of placental urokinase inhibitor in toxemia of pregnancy. ( 6360225 )
1983
13
Toxemia of pregnancy masquerading as idiopathic thrombocytopenic purpura. ( 6683829 )
1983
14
Observation of an organism found in patients with gestational trophoblastic disease and in patients with toxemia of pregnancy. ( 6295163 )
1983
15
Observation of an organism found in patients with gestational trophoblastic disease and in patients with toxemia of pregnancy. ( 6312798 )
1983
16
[Acute choriocapillaris occlusion and Elschnig's spots during a toxemia of pregnancy (author's transl)]. ( 7264211 )
1981
17
Case report: ruptured spleen, placental abruption and toxemia of pregnancy. Simultaneous complications of pregnancy. ( 927413 )
1977
18
Coagulation studies on the peripheral circulation of patients with toxemia of pregnancy: a study for the evaluation of disseminated intravascular coagulation in toxemia. ( 5165542 )
1971
19
Alkaline phosphatase activity in dialysed urine samples from patients with normal pregnancy, toxemia of pregnancy and chronic pyelonephritis. ( 5720439 )
1968
20
CHORIOANGIOMA AND TOXEMIA OF PREGNANCY. ( 14258033 )
1965
21
Severe abruptio placentae, toxemia of pregnancy, and renal biopsy. A clinicopathologic study. ( 5847911 )
1965
22
THE PATHOGENIC ROLE OF FIBRIN DEPOSITION IN THE GLOMERULAR LESIONS OF TOXEMIA OF PREGNANCY. ( 14078004 )
1963
23
Massive cerebral hemorrhage complicating toxemia of pregnancy. ( 13564171 )
1958
24
Hydatidiform mole and toxemia of pregnancy; with unusual late development of lutein cyst. ( 13469897 )
1957
25
Hydatidiform mole and toxemia of pregnancy. ( 13236124 )
1955
26
Cerebral hemorrhage as a complication in toxemia of pregnancy. ( 13138962 )
1953
27
Subhyaloid hemorrhage and exophthalmos due to ruptured intraventricular aneurysm; a case occurring in toxemia of pregnancy. ( 14914266 )
1952
28
Non-erythroblastotic hydrops fetalis recurring in association with toxemia of pregnancy. ( 18105516 )
1948
29
Toxemia of pregnancy and experimental hypertension; the production and the measurement of experimental renal hypertension. ( 20993713 )
1946
30
TOXEMIA OF PREGNANCY IN THE RABBIT : I. CLINICAL MANIFESTATIONS AND PATHOLOGY. ( 19870636 )
1937
Sources

Variations for Preeclampsia/eclampsia 1

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ClinVar genetic disease variations for Preeclampsia/eclampsia 1:

6 (show top 50) (show all 265)
# Gene Variation Type Significance SNP ID Assembly Location
1 NC_000006.12: g.66307601_66337401del29801 deletion not provided GRCh38 Chromosome 6, 66307601: 66337401
2 NC_000006.12: g.66307601_66337401del29801 deletion not provided GRCh37 Chromosome 6, 67017494: 67047294
3 NC_000006.12: g.66307601_66329847del22247 deletion not provided GRCh38 Chromosome 6, 66307601: 66329847
4 NC_000006.12: g.66307601_66329847del22247 deletion not provided GRCh37 Chromosome 6, 67017494: 67039740
5 NHSL1 NC_000006.12: g.138588771_138608297del19527 deletion not provided GRCh38 Chromosome 6, 138588771: 138608297
6 NHSL1 NC_000006.12: g.138588771_138608297del19527 deletion not provided GRCh37 Chromosome 6, 138909908: 138929434
7 AKAP12 NM_005100.3(AKAP12): c.163-8647_163-5271del deletion not provided GRCh38 Chromosome 6, 151297100: 151300476
8 AKAP12 NM_005100.3(AKAP12): c.163-8647_163-5271del deletion not provided GRCh37 Chromosome 6, 151618235: 151621611
9 VWDE NC_000007.14: g.12378976_12383095del4120 deletion not provided GRCh37 Chromosome 7, 12418602: 12422721
10 VWDE NC_000007.14: g.12378976_12383095del4120 deletion not provided GRCh38 Chromosome 7, 12378976: 12383095
11 NC_000007.14: g.19166813_19172086del5274 deletion not provided GRCh37 Chromosome 7, 19206436: 19211709
12 NC_000007.14: g.19166813_19172086del5274 deletion not provided GRCh38 Chromosome 7, 19166813: 19172086
13 CM000669.1: g.52129322_52131514dup duplication not provided GRCh38 Chromosome 7, 52061626: 52063818
14 CM000669.1: g.52129322_52131514dup duplication not provided GRCh37 Chromosome 7, 52129322: 52131514
15 CM000669.1: g.52733291_52743803dup duplication not provided GRCh37 Chromosome 7, 52733291: 52743803
16 ZNF716 NC_000007.13: g.57481104_57621951dup duplication not provided GRCh37 Chromosome 7, 57481104: 57621951
17 NC_000007.13: g.61747794_62838532dup duplication not provided GRCh37 Chromosome 7, 61747794: 62838532
18 NC_000007.14: g.62533792_63268846dup duplication not provided GRCh37 Chromosome 7, 61994170: 62729224
19 NC_000007.14: g.62533792_63268846dup duplication not provided GRCh38 Chromosome 7, 62533792: 63268846
20 IMMP2L NM_001244606.1(IMMP2L): c.239+53584_239+101346del deletion not provided GRCh38 Chromosome 7, 111385892: 111433654
21 IMMP2L NM_001244606.1(IMMP2L): c.239+53584_239+101346del deletion not provided GRCh37 Chromosome 7, 111025948: 111073710
22 NC_000007.14: g.111611393_111648317del36925 deletion not provided GRCh38 Chromosome 7, 111611393: 111648317
23 NC_000007.14: g.111611393_111648317del36925 deletion not provided GRCh37 Chromosome 7, 111251449: 111288373
24 MGAM NG_033954.1: g.83612_102741del19130 deletion not provided GRCh38 Chromosome 7, 142074490: 142093619
25 MGAM NG_033954.1: g.83612_102741del19130 deletion not provided GRCh37 Chromosome 7, 141774290: 141793419
26 NC_000007.14: g.146096986_146099665del2680 deletion not provided GRCh38 Chromosome 7, 146096986: 146099665
27 NC_000007.14: g.146096986_146099665del2680 deletion not provided GRCh37 Chromosome 7, 145794079: 145796758
28 NC_000008.11: g.5705760_5730401del24642 deletion not provided GRCh38 Chromosome 8, 5705760: 5730401
29 NC_000008.11: g.5705760_5730401del24642 deletion not provided GRCh37 Chromosome 8, 5563282: 5587923
30 NC_000008.11: g.5741877_5750560del8684 deletion not provided GRCh38 Chromosome 8, 5741877: 5750560
31 NC_000008.11: g.5741877_5750560del8684 deletion not provided GRCh37 Chromosome 8, 5599399: 5608082
32 NC_000008.11: g.5741877_5750141del8265 deletion not provided GRCh38 Chromosome 8, 5741877: 5750141
33 NC_000008.11: g.5741877_5750141del8265 deletion not provided GRCh37 Chromosome 8, 5599399: 5607663
34 NC_000008.11: g.8725599_8730079del4481 deletion not provided GRCh38 Chromosome 8, 8725599: 8730079
35 NC_000008.11: g.8725599_8730079del4481 deletion not provided GRCh37 Chromosome 8, 8583109: 8587589
36 CM000670.1: g.15899688_15939182dup duplication not provided GRCh38 Chromosome 8, 16042179: 16081673
37 CM000670.1: g.15899688_15939182dup duplication not provided GRCh37 Chromosome 8, 15899688: 15939182
38 NC_000008.11: g.16405000_16410993del5994 deletion not provided GRCh38 Chromosome 8, 16405000: 16410993
39 NC_000008.11: g.16405000_16410993del5994 deletion not provided GRCh37 Chromosome 8, 16262509: 16268502
40 MTUS1 NM_001001924.2(MTUS1): c.2288-795_2449+390del deletion not provided GRCh38 Chromosome 8, 17723282: 17724628
41 MTUS1 NM_001001924.2(MTUS1): c.2288-795_2449+390del deletion not provided GRCh37 Chromosome 8, 17580791: 17582137
42 NC_000008.11: g.21094549_21293498del198950 deletion not provided GRCh38 Chromosome 8, 21094549: 21293498
43 NC_000008.11: g.21094549_21293498del198950 deletion not provided GRCh37 Chromosome 8, 20952060: 21151009
44 NC_000008.11: g.82359160_82381637del22478 deletion not provided GRCh38 Chromosome 8, 82359160: 82381637
45 NC_000008.11: g.82359160_82381637del22478 deletion not provided GRCh37 Chromosome 8, 83271395: 83293872
46 NC_000009.12: g.11414180_11463799del49620 deletion not provided GRCh38 Chromosome 9, 11414180: 11463799
47 NC_000009.12: g.11414180_11463799del49620 deletion not provided GRCh37 Chromosome 9, 11414180: 11463799
48 NC_000009.12: g.24502739_24515113del12375 deletion not provided GRCh38 Chromosome 9, 24502739: 24515113
49 NC_000009.12: g.24502739_24515113del12375 deletion not provided GRCh37 Chromosome 9, 24502737: 24515111
50 NC_000009.12: g.83588331_83591428del3098 deletion not provided GRCh38 Chromosome 9, 83588331: 83591428
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Expression for Preeclampsia/eclampsia 1

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Search GEO for disease gene expression data for Preeclampsia/eclampsia 1.
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Pathways for Preeclampsia/eclampsia 1

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GO Terms for Preeclampsia/eclampsia 1

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Sources for Preeclampsia/eclampsia 1

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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