Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
PEE1
MCID: PRC031
MIFTS: 38

Preeclampsia/eclampsia 1 (PEE1)

Categories: Blood diseases, Genetic diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Preeclampsia/eclampsia 1

About this section

MalaCards integrated aliases for Preeclampsia/eclampsia 1:

Name: Preeclampsia/eclampsia 1 56 29 13
Preeclampsia/eclampsia, Type 1 39
Toxemia of Pregnancy 56
Pregnancy Toxemias 54
Pre-Eclampsia 71
Preg1 56
Pee1 56
Pee 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant

Miscellaneous:
majority of cases are sporadic
occurs in ~3% pregnancies in western populations
clinical manifestation ranges from mild, transient hypertension to hellp syndrome (hemolysis, elevated liver enzymes, and low platelets)


HPO:

31
preeclampsia/eclampsia 1:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Preeclampsia/eclampsia 1

About this section
OMIM : 56 Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide (summary by Payne et al., 2011). Preeclampsia is otherwise known as gestational proteinuric hypertension (Davey and MacGillivray, 1988). A high proportion of patients with preeclampsia have glomerular endotheliosis, the unique histopathologic feature of the condition (Fisher et al., 1981). A distinct form of severe preeclampsia is characterized by hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome) (Brown et al., 2000). (189800)

MalaCards based summary : Preeclampsia/eclampsia 1, also known as preeclampsia/eclampsia, type 1, is related to pre-eclampsia and eclampsia, and has symptoms including edema and hyperemesis gravidarum. An important gene associated with Preeclampsia/eclampsia 1 is NOS3 (Nitric Oxide Synthase 3). The drugs Dinoprostone and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and placenta, and related phenotypes are proteinuria and edema

Sources

Related Diseases for Preeclampsia/eclampsia 1

About this section

Diseases in the Preeclampsia/eclampsia 1 family:

Preeclampsia/eclampsia 2 Preeclampsia/eclampsia 3
Preeclampsia/eclampsia 4 Preeclampsia/eclampsia 5

Diseases related to Preeclampsia/eclampsia 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 pre-eclampsia 31.1 SERPINC1 PEE1 NOS3
2 eclampsia 31.0 SERPINC1 PEE1 NOS3
3 placental abruption 29.7 SERPINC1 NOS3
4 vascular disease 29.6 SERPINC1 NOS3
5 thrombosis 29.4 SERPINC1 NOS3
6 stroke, ischemic 29.2 SERPINC1 NOS3
7 pulmonary edema 29.2 SERPINC1 NOS3
8 thrombotic thrombocytopenic purpura 11.3
9 retinal detachment 10.3
10 chlamydia 10.3
11 acute cystitis 10.3
12 cystitis 10.3
13 encephalopathy 10.3
14 mild pre-eclampsia 10.3
15 severe pre-eclampsia 10.2
16 inflammatory bowel disease 10.2
17 hepatic coma 10.2
18 hepatic encephalopathy 10.2
19 interstitial cystitis 10.2
20 constipation 10.2
21 irritable bowel syndrome 10.2
22 disseminated intravascular coagulation 10.2
23 hypertension, essential 10.1
24 hypertensive retinopathy 10.1
25 asparagus, specific smell hypersensitivity 10.0
26 celiac disease 1 10.0
27 cystinosis, late-onset juvenile or adolescent nephropathic type 10.0
28 meningioma, radiation-induced 10.0
29 meningioma, familial 10.0
30 diabetes mellitus, ketosis-prone 10.0
31 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
32 aphasia 10.0
33 cystinosis 10.0
34 spinal meningioma 10.0
35 gestational diabetes 10.0
36 nephrotic syndrome 10.0
37 uveitis 10.0
38 transitional cell carcinoma 10.0
39 vaccinia 10.0
40 secretory meningioma 10.0
41 lymphoplasmacyte-rich meningioma 10.0
42 cerebrovascular disease 10.0
43 head injury 10.0
44 lysosomal disease 10.0
45 pain agnosia 10.0
46 malignant hypertension 10.0
47 blood coagulation disease 10.0
48 hellp syndrome 10.0
49 uremia 10.0
50 placenta disease 10.0

Graphical network of the top 20 diseases related to Preeclampsia/eclampsia 1:



Diseases related to Preeclampsia/eclampsia 1
Sources

Symptoms & Phenotypes for Preeclampsia/eclampsia 1

About this section

Human phenotypes related to Preeclampsia/eclampsia 1:

31 (show all 10)
# Description HPO Frequency HPO Source Accession
1 proteinuria 31 HP:0000093
2 edema 31 HP:0000969
3 intrauterine growth retardation 31 HP:0001511
4 hypertension 31 HP:0000822
5 elevated hepatic transaminase 31 HP:0002910
6 thrombocytopenia 31 HP:0001873
7 preeclampsia 31 HP:0100602
8 eclampsia 31 HP:0100601
9 maternal hypertension 31 HP:0008071
10 seizure 31 HP:0001250

Symptoms via clinical synopsis from OMIM:

56
Genitourinary Kidneys:
proteinuria

Muscle Soft Tissue:
edema

Cardiovascular Vascular:
maternal hypertension (after 20th week gestation, resolved postpartum)

Abdomen Liver:
elevated liver enzymes

Hematology:
thrombocytopenia (hellp syndrome)

Laboratory Abnormalities:
proteinuria
elevated liver enzymes

Growth Other:
intrauterine growth retardation (in fetus)

Prenatal Manifestations Maternal:
maternal hypertension (after 20th week gestation, resolved postpartum)

Neurologic Central Nervous System:
seizures (eclampsia)

Clinical features from OMIM:

189800

UMLS symptoms related to Preeclampsia/eclampsia 1:


edema, hyperemesis gravidarum
Sources

Drugs & Therapeutics for Preeclampsia/eclampsia 1

About this section

Drugs for Preeclampsia/eclampsia 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 314)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4 363-24-6 5280360
2
leucovorin Approved Phase 4 58-05-9 6006 143
3
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
4
Enoxaparin Approved Phase 4 9005-49-6 772
5
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
6
Dalteparin Approved Phase 4 9005-49-6
7
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
8
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
9
Captopril Approved Phase 4 62571-86-2 44093
10
Misoprostol Approved Phase 4 59122-46-2 5282381
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
14
Enalaprilat Approved Phase 4 76420-72-9 6917719
15
Carbetocin Approved, Investigational Phase 4 37025-55-1 71715 16681432
16
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
17
Azithromycin Approved Phase 4 83905-01-5 447043 55185
18
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
19
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
20
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
21
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
22
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
23
Desogestrel Approved Phase 4 54024-22-5 40973
24
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
25
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
26
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
27
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
28
Metformin Approved Phase 4 657-24-9 14219 4091
29
Glyburide Approved Phase 4 10238-21-8 3488
30
Phenylephrine Approved Phase 4 59-42-7 6041
31
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
32
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
33
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
34
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
35 Ergocalciferols Phase 4
36 Vitamin D2 Phase 4
37 Vitamin B Complex Phase 4
38 Folate Phase 4
39 Vitamin B9 Phase 4
40 Antibodies, Antiphospholipid Phase 4
41 calcium heparin Phase 4
42 Heparin, Low-Molecular-Weight Phase 4
43 Anti-Asthmatic Agents Phase 4
44 Bronchodilator Agents Phase 4
45 Adrenergic beta-Agonists Phase 4
46 Albuterol Phase 4
47 Anti-Infective Agents Phase 4
48 Anesthetics Phase 4
49 Antacids Phase 4
50 Anti-Ulcer Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 632)
# Name Status NCT ID Phase Drugs
1 Low Dose Calcium Supplementation to Prevent Preeclampsia: a Cluster Randomized Study Unknown status NCT02338687 Phase 4
2 Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension Unknown status NCT03449277 Phase 4 Oral Tablet
3 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
4 Effectiveness Of Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia: Randomized Placebo-Controlled Clinical Trial Unknown status NCT01361425 Phase 4 methildopa;placebo
5 Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial) Unknown status NCT00117546 Phase 4 alpha methyldopa
6 Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Unknown status NCT03318211 Phase 4 Magnesium Sulfate
7 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Unknown status NCT02911701 Phase 4 Acetaminophen;Ibuprofen
8 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Unknown status NCT03233880 Phase 4 Azithromycin 1gm
9 Magnesium Deficiency in Cirrhotic Patients Unknown status NCT01894867 Phase 4
10 Effect of Administering Intravenous Magnesium Sulfate Heptahydrate (MgSO4•7H2O) on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients in 3rd Trimester of Pregnancy Unknown status NCT03237000 Phase 4 MgSO4
11 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Unknown status NCT02920593 Phase 4 Vitamin D3
12 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
13 An Open-label Randomized-Controlled Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
14 Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsia: a Randomized Clinical Trial Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
15 A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Serum Concentrations Obtained in the Treatment of Severe Preeclampsia With a Repeat Bolus Intravenous Magnesium Sulfate Regimen Administered With the Springfusor Infusion Pump to a Continuous Intravenous Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
16 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
17 Efficacy and Safety of One Gram Versus Two Grams Intravenous Maintenance Dose of Magnesium Sulfate in Women With Severe Pre-eclampsia: a Randomized Clinical Trial. Completed NCT03164304 Phase 4 Magnesium Sulfate
18 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
19 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Completed NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
20 Adding Magnesium Sulphate to Epidural Levobupivacaine in Elective Caesarian Section for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
21 A Randomized-controlled Trial to Assess the Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed NCT02891174 Phase 4 Ibuprofen;Acetaminophen
22 Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women With Severe Preeclampsia: a Randomized Clinical Trial Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
23 Randomized Trial of Magnesium Sulfate in Obese Preeclamptic Women Completed NCT02835339 Phase 4 Magnesium sulfate 4g loading dose, 1g/hr infusion;Magnesium sulfate 6g loading dose, 2g/hr infusion
24 Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients Completed NCT03506724 Phase 4 Nifedipine;Labetalol
25 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
26 A Prospective Multi-centre Randomised Comparison on Induction of Labour With Double-balloon Installation Device Versus Prostaglandin E2 Minprostin Completed NCT01255839 Phase 4 Minprostin
27 Low Molecular Weight Heparin for Treatment of Recurrent Miscarriage With Negative Antiphospholipid Antibodies: a Randomized Controlled Trial Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
28 Albuterol Dose-Response on Pulmonary Function Testing in Preterm Infants at Risk of Bronchopulmonary Dysplasia Completed NCT02447250 Phase 4 Varied albuterol dose response
29 Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
30 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
31 Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial Recruiting NCT04051567 Phase 4 Aspirin 100mg
32 Efficacy of 17-Hydroxyprogesterone Caproate in Expectantly Managed Early-onset Preeclampsia: A Randomized Controlled Study Recruiting NCT04077853 Phase 4 17 Hydroxyprogesterone Capronate
33 Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor Recruiting NCT04392375 Phase 4 Nifedipine 30 MG;Placebos
34 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Recruiting NCT03570632 Phase 4 Metformin
35 Personalized Hemodynamically Guided Antihypertensive Treatment in Pregnant Women With Mild to Moderate Hypertension: a Randomized Controlled Trial Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
36 The Effect of 81mg vs 162mg ASA for Preeclampsia Prevention in Obese Women at High Risk for Developing Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
37 A Randomized Controlled Trial Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period Recruiting NCT04236258 Phase 4 NIFEdipine ER;Enalapril
38 Acute Control of Chronic Hypertension in Preeclampsia Recruiting NCT03877692 Phase 4 Experimental dosing of labetalol
39 Acute Labetalol Use in Preeclampsia Randomized Trial Recruiting NCT03872336 Phase 4 Experimental labetalol dose
40 Carbetocin Versus Misoprostol for Prevention of Postpartum Hemorrhage in Pregnant Women at High Risk Following C.S. Recruiting NCT02277067 Phase 4 Carbetocin;Misoprostol
41 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
42 Interaction Between Intravenous Magnesium Sulphate and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block - A Randomized, Double Blinded, Electrophysiological Study Recruiting NCT03497923 Phase 4 Magnesium Sulfate
43 The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age Recruiting NCT04047849 Phase 4 Antibiotics, oral Azithromycin and oral Amoxicillin
44 Use of Etonogestrel-releasing Contraceptive Implant in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
45 Postpartum Management of Gestational Hypertensive Disorders Using Furosemide: A Randomized Controlled Trial Enrolling by invitation NCT04343235 Phase 4 furosemide;labetalol
46 Lignocaine Nebulization for Attenuation of Intubation Stress Response in Patients With Severe Pre-eclampsia: a Prospective Double-blinded Placebo-controlled Trial Not yet recruiting NCT04441073 Phase 4 Lignocaine;Placebo
47 A Prospective Randomized Clinical Research Trial Comparing the Incidence of Preeclampsia Between Pregnant Women Receiving Tdap Vaccinations at Week 28 and Those Receiving Tdap Vaccinations at Week 36 Not yet recruiting NCT04424693 Phase 4 Tdap Vaccine Administration
48 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes: A Single Site Randomized Trial Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
49 A Pragmatic Randomized Study Comparing 81 mg Aspirin Versus 162 mg Aspirin in the Prevention of Preeclampsia During Pregnancy Not yet recruiting NCT04158830 Phase 4 Aspirin 81 mg Enteric Coated Tab - 1 tablet;Aspirin 81 mg Enteric Coated Tab - 2 tablets
50 Impact of Vasopressor Administration on Maternal and Neonatal Outcomes in Women With Pre-eclampsia Terminated NCT02025426 Phase 4 Phenylephrine;Ephedrine

Search NIH Clinical Center for Preeclampsia/eclampsia 1

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Magnesium Sulfate
Sources

Genetic Tests for Preeclampsia/eclampsia 1

About this section

Genetic tests related to Preeclampsia/eclampsia 1:

# Genetic test Affiliating Genes
1 Preeclampsia/eclampsia 1 29 NOS3
Sources

Anatomical Context for Preeclampsia/eclampsia 1

About this section

MalaCards organs/tissues related to Preeclampsia/eclampsia 1:

40
Testes, Endothelial, Placenta, Liver, Lung, Heart, Whole Blood
Sources

Publications for Preeclampsia/eclampsia 1

About this section

Articles related to Preeclampsia/eclampsia 1:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. 56
28628106 2017
2
Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia. 56
25143393 2015
3
HELLP babies link a novel lincRNA to the trophoblast cell cycle. 56
23093777 2012
4
Assessment, surveillance and prognosis in pre-eclampsia. 56
21459048 2011
5
Pre-eclampsia: pathophysiology, diagnosis, and management. 56
21822394 2011
6
Familial aggregation of preeclampsia and intrauterine growth restriction in a genetically isolated population in The Netherlands. 56
18612323 2008
7
Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. 56
18660815 2008
8
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. 56
18469803 2008
9
Extremely skewed X-chromosome inactivation is increased in pre-eclampsia. 56
17115188 2007
10
Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. 56
15889386 2005
11
The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. 56
16059745 2005
12
Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study. 56
15384082 2004
13
Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. 56
15477349 2004
14
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. 56
14673478 2004
15
Circulating angiogenic factors and the risk of preeclampsia. 56
14764923 2004
16
The genetics of pre-eclampsia: a feto-placental or maternal problem? 56
12859402 2003
17
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. 56
12618519 2003
18
Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia. 56
12173035 2002
19
Paternal contribution to the risk for pre-eclampsia. 56
11826024 2002
20
A genome-wide scan for preeclampsia in the Netherlands. 56
11781687 2001
21
A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. 56
11283205 2001
22
Paternal and maternal components of the predisposition to preeclampsia. 56
11259719 2001
23
Pathogenesis and genetics of pre-eclampsia. 56
11197372 2001
24
A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. 56
11035632 2000
25
Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. 56
10866201 2000
26
Expression and relationship between endothelin-1 messenger ribonucleic acid (mRNA) and inducible/endothelial nitric oxide synthase mRNA isoforms from normal and preeclamptic placentas. 56
10852470 2000
27
The detection, investigation and management of hypertension in pregnancy: full consensus statement. 56
10925900 2000
28
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. 56
10655155 2000
29
Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies. 56
10576196 1999
30
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. 56
10441346 1999
31
Twin mothers, pregnancy hypertension and pre-eclampsia. 56
10426615 1999
32
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. 56
10194466 1999
33
Increased frequency of genetic thrombophilia in women with complications of pregnancy. 56
9878639 1999
34
Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism. 56
9459326 1998
35
Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. 56
9311740 1997
36
Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. 56
9192280 1997
37
A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. 56
9150163 1997
38
HELLP syndrome associated with factor V R506Q mutation. 56
8616100 1996
39
Concerns about the genetics of pre-eclampsia. 56
8488831 1993
40
An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance. 56
1550119 1992
41
Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus? 56
1760418 1991
42
Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. 56
2242360 1990
43
Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta. 56
1975853 1990
44
Association between susceptibility to pre-eclampsia within families and HLA DR4. 56
2572795 1989
45
Genetics of pre-eclampsia. 56
2901618 1988
46
Genetic control of susceptibility to eclampsia and miscarriage. 56
3415930 1988
47
The classification and definition of the hypertensive disorders of pregnancy. 56
3364501 1988
48
Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. 56
3768285 1986
49
Hypertension in pregnancy: clinical-pathological correlations and remote prognosis. 56
7242320 1981
50
Genetic control of pre-eclampsia. 56
6102633 1980
Sources

Variations for Preeclampsia/eclampsia 1

About this section
Sources

Expression for Preeclampsia/eclampsia 1

About this section
Search GEO for disease gene expression data for Preeclampsia/eclampsia 1.
Sources

Pathways for Preeclampsia/eclampsia 1

About this section
Sources

GO Terms for Preeclampsia/eclampsia 1

About this section
Sources

Sources for Preeclampsia/eclampsia 1

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....