MCID: PRG010
MIFTS: 35

Pregnancy Adenoma

Categories: Cancer diseases

Aliases & Classifications for Pregnancy Adenoma

MalaCards integrated aliases for Pregnancy Adenoma:

Name: Pregnancy Adenoma 12 15
Lactating Adenoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7539
NCIt 50 C9473
UMLS 73 C1266023

Summaries for Pregnancy Adenoma

Disease Ontology : 12 A breast adenoma that occurs during pregnancy.

MalaCards based summary : Pregnancy Adenoma, also known as lactating adenoma, is related to breast fibroadenoma and adenoma. An important gene associated with Pregnancy Adenoma is NT5C1B (5'-Nucleotidase, Cytosolic IB), and among its related pathways/superpathways are Developmental Biology and Circadian entrainment. Affiliated tissues include lung, skin and kidney, and related phenotypes are cellular and growth/size/body region

Related Diseases for Pregnancy Adenoma

Diseases related to Pregnancy Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 29.9 KRT14 KRT8 MED12
2 adenoma 10.5
3 basal cell carcinoma, infundibulocystic 10.3 KRT14 KRT17
4 breast adenoma 10.2 KRT17 MED12 NT5C1B
5 multiple enchondromatosis, maffucci type 10.2 GNAS NT5C1B
6 lichen planopilaris 10.2 KRT14 KRT5
7 spiradenoma 10.2 KRT14 KRT7
8 thyroid hurthle cell adenoma 10.2 KRT14 PIK3CA
9 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT14 KRT5
10 clear cell basal cell carcinoma 10.2 KRT17 KRT7
11 epidermolysis bullosa simplex, localized 10.2 KRT14 KRT5
12 epidermolysis bullosa simplex, generalized 10.2 KRT14 KRT5
13 dermatosis papulosa nigra 10.2 FGFR3 PIK3CA
14 oncocytic breast carcinoma 10.2 KRT14 KRT7
15 endolymphatic sac tumor 10.2 KRT7 KRT8
16 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT14 KRT5
17 hidrocystoma 10.2 KRT7 KRT8
18 adenoid squamous cell carcinoma 10.2 KRT7 KRT8
19 bowen's disease 10.2 KRT17 KRT7
20 plasminogen activator inhibitor-1 deficiency 10.2 PLAT SERPINF2
21 breast benign neoplasm 10.2 KRT14 KRT5 MED12
22 thoracic benign neoplasm 10.2 KRT14 KRT5 MED12
23 inverted transitional papilloma 10.2 KRT5 KRT7
24 ceruminoma 10.2 KRT5 KRT7
25 benign mesothelioma 10.1 KRT5 KRT7
26 pre-malignant neoplasm 10.1 KRT14 KRT17 KRT5
27 nasal cavity cancer 10.1 KRT7 KRT8
28 in situ carcinoma 10.1 KRT14 KRT17 KRT5
29 intracranial embolism 10.1 PLAT SERPINF2
30 sensory organ benign neoplasm 10.1 KRT5 KRT7
31 bile duct mucoepidermoid carcinoma 10.1 KRT5 KRT7
32 platelet aggregation, spontaneous 10.1 PLAT SERPINF2
33 middle ear adenoma 10.1 KRT5 KRT7
34 appendix disease 10.1 GNAS KRT7
35 ductal carcinoma in situ 10.1 KRT14 KRT5 KRT8
36 brooke-spiegler syndrome 10.1 KRT14 KRT7 KRT8
37 malignant biphasic mesothelioma 10.1 KRT5 KRT7
38 breast squamous cell carcinoma 10.1 KRT14 KRT5 PIK3CA
39 dowling-degos disease 1 10.1 FGFR3 GNAS KRT5
40 craniopharyngioma 10.1 KRT14 KRT7 KRT8
41 marantic endocarditis 10.1 PLAT SERPINF2
42 eccrine sweat gland neoplasm 10.1 KRT17 KRT5 KRT7
43 hidradenoma 10.1 KRT7 PIK3CA
44 benign breast adenomyoepithelioma 10.1 KRT14 KRT5 KRT7
45 sweat gland disease 10.1 KRT14 KRT5 KRT7
46 tonsil cancer 10.1 KRT14 KRT5 KRT7
47 peritoneum cancer 10.1 KRT5 KRT7
48 clear cell adenofibroma 10.1 KRT7 PIK3CA
49 oropharynx cancer 10.1 KRT14 KRT5 KRT7
50 spindle cell carcinoma 10.1 KRT14 KRT5 KRT7

Graphical network of the top 20 diseases related to Pregnancy Adenoma:



Diseases related to Pregnancy Adenoma

Symptoms & Phenotypes for Pregnancy Adenoma

MGI Mouse Phenotypes related to Pregnancy Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 FGFR3 GNAS KRT14 KRT17 KRT19 KRT7
2 growth/size/body region MP:0005378 10.02 FGFR3 GNAS KRT14 KRT17 KRT19 KRT5
3 craniofacial MP:0005382 9.95 FGFR3 GNAS KRT14 KRT17 KRT5 MED12
4 digestive/alimentary MP:0005381 9.91 FGFR3 KRT14 KRT17 KRT19 KRT5 KRT8
5 integument MP:0010771 9.76 FGFR3 GNAS KRT14 KRT17 KRT19 KRT5
6 mortality/aging MP:0010768 9.7 CTNNBL1 FGFR3 GNAS KRT14 KRT17 KRT19
7 hearing/vestibular/ear MP:0005377 9.65 FGFR3 GNAS KRT14 KRT8 PLAT
8 no phenotypic analysis MP:0003012 9.17 CD68 FGFR3 GNAS KRT17 KRT19 KRT5

Drugs & Therapeutics for Pregnancy Adenoma

Search Clinical Trials , NIH Clinical Center for Pregnancy Adenoma

Genetic Tests for Pregnancy Adenoma

Anatomical Context for Pregnancy Adenoma

MalaCards organs/tissues related to Pregnancy Adenoma:

41
Lung, Skin, Kidney, Liver, Heart, Thymus, Appendix

Publications for Pregnancy Adenoma

Articles related to Pregnancy Adenoma:

(show all 29)
# Title Authors Year
1
Spuriously aggressive features of a lactating adenoma prompting repeated biopsies. ( 28491154 )
2017
2
Huge lactating adenoma of the breast: Case report. ( 28269736 )
2017
3
Lactating Adenoma of the Breast. ( 27197575 )
2016
4
Case report of a large lactating adenoma with rapid antepartum enlargement. ( 26855073 )
2016
5
Concurrent Lactating Adenoma and Infiltrating Ductal Carcinoma: A Case Report. ( 26435957 )
2015
6
Lactating adenoma with infiltrating ductal carcinoma breast in a pregnant woman. ( 26960485 )
2015
7
Lactating Adenoma in the Presence of Galactoceles. ( 30394444 )
2015
8
AIRP best cases in radiologic-pathologic correlation: lactating adenoma. ( 23479707 )
2013
9
Fine Needle Aspiration Cytologic Diagnosis of Lactating Adenoma: Report of two Cases. ( 24298549 )
2013
10
Vulva fibroadenoma associated with lactating adenoma in a 26-year-old nigerian female. ( 24062962 )
2013
11
Vulvar lactating adenoma associated to a fibroadenoma: common neoplasms in an uncommon site. ( 23330038 )
2012
12
Gigantomastia and vulvar lactating adenoma in a patient with myasthenia during pregnancy. ( 20739013 )
2010
13
Giant lactating adenoma of the breast. ( 24946360 )
2010
14
Breast MRI in a case of "early onset" lactating adenoma. ( 19120375 )
2009
15
Early onset lactating adenoma and the role of breast MRI: a case report. ( 19183446 )
2009
16
Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman. ( 15623491 )
2005
17
Lactating adenoma: a diagnosis of exclusion. ( 11906446 )
2001
18
Lactating adenoma--cytomorphologic study with review of literature. ( 12035360 )
2001
19
Lactating adenoma presenting as a giant breast mass. ( 10819069 )
2000
20
Lactating Adenoma: Sonographic Features. ( 11348374 )
2000
21
Infarcted lactating adenoma presenting as a rapidly enlarging breast mass. ( 10511151 )
1999
22
Lactating adenoma: US features and literature review. ( 9423682 )
1998
23
Lactating adenoma of the breast: antepartum and postpartum sonographic and color Doppler imaging appearances with histopathologic correlation. ( 9166808 )
1997
24
A Case Reprot of Lactating Adenoma of the Breast and Review of the literatures in Japan. ( 11091567 )
1996
25
Chemotherapy-related resolution of radiogallium uptake in a lactating adenoma. ( 8403727 )
1993
26
A lactating adenoma of the breast. ( 1398265 )
1992
27
Fine needle aspiration cytology of lactating adenoma of the breast. A comparative light microscopic and morphometric study. ( 2153326 )
1990
28
Lactating adenoma of breast. ( 13049201 )
1953
29
Lactating Adenoma of Breast. ( 19987583 )
1930

Variations for Pregnancy Adenoma

Expression for Pregnancy Adenoma

Search GEO for disease gene expression data for Pregnancy Adenoma.

Pathways for Pregnancy Adenoma

GO Terms for Pregnancy Adenoma

Cellular components related to Pregnancy Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 A2M GNAS KRT14 KRT17 KRT19 KRT5
2 keratin filament GO:0045095 9.56 KRT14 KRT5 KRT7 KRT8
3 apicolateral plasma membrane GO:0016327 9.4 KRT19 KRT8
4 costamere GO:0043034 9.37 KRT19 KRT8
5 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT19 KRT8
6 cell periphery GO:0071944 9.26 KRT14 KRT17 KRT19 KRT8
7 intermediate filament GO:0005882 9.1 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8

Biological processes related to Pregnancy Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.5 KRT14 KRT17 KRT5
2 keratinization GO:0031424 9.43 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8
3 fibrinolysis GO:0042730 9.37 PLAT SERPINF2
4 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT19 KRT8
6 cornification GO:0070268 9.1 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8

Molecular functions related to Pregnancy Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 A2M CTNNBL1 FGFR3 GNAS KRT14 KRT17
2 structural constituent of cytoskeleton GO:0005200 8.92 KRT14 KRT17 KRT19 KRT5

Sources for Pregnancy Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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