MCID: PRG010
MIFTS: 36

Pregnancy Adenoma

Categories: Cancer diseases

Aliases & Classifications for Pregnancy Adenoma

MalaCards integrated aliases for Pregnancy Adenoma:

Name: Pregnancy Adenoma 12 15
Lactating Adenoma 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7539
NCIt 51 C9473
UMLS 74 C1266023

Summaries for Pregnancy Adenoma

Disease Ontology : 12 A breast adenoma that occurs during pregnancy.

MalaCards based summary : Pregnancy Adenoma, also known as lactating adenoma, is related to breast fibroadenoma and adenocarcinoma. An important gene associated with Pregnancy Adenoma is NT5C1B (5'-Nucleotidase, Cytosolic IB), and among its related pathways/superpathways are Developmental Biology and Circadian entrainment. Affiliated tissues include skin, thyroid and kidney, and related phenotypes are cellular and growth/size/body region

Related Diseases for Pregnancy Adenoma

Diseases related to Pregnancy Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 30.0 KRT14 KRT8 MED12 PGR
2 adenocarcinoma 29.6 FGFR3 GNAS PIK3CA PTEN
3 adenoma 10.5
4 basal cell carcinoma, infundibulocystic 10.4 KRT14 KRT17
5 breast adenoma 10.4 KRT17 MED12 NT5C1B
6 clear cell basal cell carcinoma 10.4 KRT17 KRT7
7 lichen planopilaris 10.4 KRT14 KRT5
8 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT14 KRT5
9 endolymphatic sac tumor 10.3 KRT7 KRT8
10 dermatosis papulosa nigra 10.3 FGFR3 PIK3CA
11 plasminogen activator inhibitor-1 deficiency 10.3 PLAT SERPINF2
12 epidermolysis bullosa simplex, localized 10.3 KRT14 KRT5
13 inverted transitional papilloma 10.3 KRT5 KRT7
14 ceruminoma 10.3 KRT5 KRT7
15 multiple enchondromatosis, maffucci type 10.3 GNAS NT5C1B
16 hidrocystoma 10.3 KRT7 KRT8
17 bizarre leiomyoma 10.3 MED12 PGR
18 breast malignant phyllodes tumor 10.3 NT5C1B PGR
19 benign mesothelioma 10.3 KRT5 KRT7
20 adenoid squamous cell carcinoma 10.3 KRT7 KRT8
21 sensory organ benign neoplasm 10.3 KRT5 KRT7
22 epidermolysis bullosa simplex, generalized 10.3 KRT14 KRT5
23 bile duct mucoepidermoid carcinoma 10.3 KRT5 KRT7
24 middle ear adenoma 10.3 KRT5 KRT7
25 breast metaplastic carcinoma 10.3 KRT5 PGR
26 platelet aggregation, spontaneous 10.3 PLAT SERPINF2
27 brooke-spiegler syndrome 10.3 KRT14 KRT7 KRT8
28 eccrine papillary adenocarcinoma 10.2 KRT7 PGR
29 breast squamous cell carcinoma 10.2 KRT14 KRT5 PIK3CA
30 benign breast adenomyoepithelioma 10.2 KRT14 KRT5 KRT7
31 craniopharyngioma 10.2 KRT14 KRT7 KRT8
32 dowling-degos disease 1 10.2 FGFR3 GNAS KRT5
33 eccrine sweat gland neoplasm 10.2 KRT17 KRT5 KRT7
34 endosalpingiosis 10.2 KRT7 PGR
35 tonsil cancer 10.2 KRT14 KRT5 KRT7
36 oropharynx cancer 10.2 KRT14 KRT5 KRT7
37 intestinal impaction 10.2 PLG SERPINF2
38 prostate squamous cell carcinoma 10.2 KRT5 KRT7 KRT8
39 lymphoepithelioma-like carcinoma 10.2 KRT5 KRT7 KRT8
40 nasal cavity squamous cell carcinoma 10.2 KRT5 KRT7 KRT8
41 atypical choroid plexus papilloma 10.2 KRT5 KRT7 KRT8
42 nasal cavity cancer 10.2 KRT7 KRT8
43 peritoneal benign neoplasm 10.2 MED12 PGR
44 cribriform carcinoma 10.2 KRT7 PGR
45 breast duct papilloma 10.2 PGR PTEN
46 benign metastasizing leiomyoma 10.2 KRT7 PGR
47 lipid-rich carcinoma 10.2 KRT14 KRT5 PGR
48 apocrine adenocarcinoma 10.2 KRT5 PGR
49 alpha-2-plasmin inhibitor deficiency 10.2 PLG SERPINF2
50 malignant spiradenoma 10.2 KRT5 KRT7 PIK3CA

Graphical network of the top 20 diseases related to Pregnancy Adenoma:



Diseases related to Pregnancy Adenoma

Symptoms & Phenotypes for Pregnancy Adenoma

MGI Mouse Phenotypes related to Pregnancy Adenoma:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 FGFR3 GNAS KRT14 KRT17 KRT19 KRT7
2 growth/size/body region MP:0005378 10.26 FGFR3 GNAS KRT14 KRT17 KRT19 KRT5
3 cardiovascular system MP:0005385 10.2 GNAS KRT19 KRT8 MED12 PGR PIK3CA
4 homeostasis/metabolism MP:0005376 10.2 FGFR3 GNAS KRT14 KRT7 KRT8 PGR
5 digestive/alimentary MP:0005381 10.16 FGFR3 KRT14 KRT17 KRT19 KRT5 KRT8
6 integument MP:0010771 10.14 FGFR3 GNAS KRT14 KRT17 KRT19 KRT5
7 immune system MP:0005387 10.13 CD68 FGFR3 GNAS KRT14 KRT8 PGR
8 mortality/aging MP:0010768 10.13 FGFR3 GNAS KRT14 KRT17 KRT19 KRT5
9 endocrine/exocrine gland MP:0005379 10.1 GNAS KRT14 KRT19 PGR PIK3CA PLAT
10 craniofacial MP:0005382 10.07 FGFR3 GNAS KRT14 KRT17 KRT5 MED12
11 neoplasm MP:0002006 9.86 FGFR3 GNAS KRT14 KRT19 PGR PIK3CA
12 limbs/digits/tail MP:0005371 9.85 FGFR3 GNAS KRT5 MED12 PGR PTEN
13 no phenotypic analysis MP:0003012 9.76 CD68 FGFR3 GNAS KRT17 KRT19 KRT5
14 reproductive system MP:0005389 9.61 FGFR3 KRT14 KRT19 KRT8 PGR PIK3CA
15 skeleton MP:0005390 9.28 CD68 FGFR3 GNAS KRT19 MED12 PGR

Drugs & Therapeutics for Pregnancy Adenoma

Search Clinical Trials , NIH Clinical Center for Pregnancy Adenoma

Genetic Tests for Pregnancy Adenoma

Anatomical Context for Pregnancy Adenoma

MalaCards organs/tissues related to Pregnancy Adenoma:

42
Skin, Thyroid, Kidney, Ovary, Pancreas, Prostate, Thymus

Publications for Pregnancy Adenoma

Articles related to Pregnancy Adenoma:

(show all 29)
# Title Authors Year
1
Spuriously aggressive features of a lactating adenoma prompting repeated biopsies. ( 28491154 )
2017
2
Huge lactating adenoma of the breast: Case report. ( 28269736 )
2017
3
Lactating Adenoma of the Breast. ( 27197575 )
2016
4
Case report of a large lactating adenoma with rapid antepartum enlargement. ( 26855073 )
2016
5
Lactating adenoma with infiltrating ductal carcinoma breast in a pregnant woman. ( 26960485 )
2015
6
Concurrent Lactating Adenoma and Infiltrating Ductal Carcinoma: A Case Report. ( 26435957 )
2015
7
Lactating Adenoma in the Presence of Galactoceles. ( 30394444 )
2015
8
Vulva fibroadenoma associated with lactating adenoma in a 26-year-old nigerian female. ( 24062962 )
2013
9
AIRP best cases in radiologic-pathologic correlation: lactating adenoma. ( 23479707 )
2013
10
Fine Needle Aspiration Cytologic Diagnosis of Lactating Adenoma: Report of two Cases. ( 24298549 )
2013
11
Vulvar lactating adenoma associated to a fibroadenoma: common neoplasms in an uncommon site. ( 23330038 )
2012
12
Gigantomastia and vulvar lactating adenoma in a patient with myasthenia during pregnancy. ( 20739013 )
2010
13
Giant lactating adenoma of the breast. ( 24946360 )
2010
14
Breast MRI in a case of "early onset" lactating adenoma. ( 19120375 )
2009
15
Early onset lactating adenoma and the role of breast MRI: a case report. ( 19183446 )
2009
16
Coexistence of lactating adenoma and invasive ductal adenocarcinoma of the breast in a pregnant woman. ( 15623491 )
2005
17
Lactating adenoma: a diagnosis of exclusion. ( 11906446 )
2001
18
Lactating adenoma--cytomorphologic study with review of literature. ( 12035360 )
2001
19
Lactating adenoma presenting as a giant breast mass. ( 10819069 )
2000
20
Lactating Adenoma: Sonographic Features. ( 11348374 )
2000
21
Infarcted lactating adenoma presenting as a rapidly enlarging breast mass. ( 10511151 )
1999
22
Lactating adenoma: US features and literature review. ( 9423682 )
1998
23
Lactating adenoma of the breast: antepartum and postpartum sonographic and color Doppler imaging appearances with histopathologic correlation. ( 9166808 )
1997
24
A Case Reprot of Lactating Adenoma of the Breast and Review of the literatures in Japan. ( 11091567 )
1996
25
Chemotherapy-related resolution of radiogallium uptake in a lactating adenoma. ( 8403727 )
1993
26
A lactating adenoma of the breast. ( 1398265 )
1992
27
Fine needle aspiration cytology of lactating adenoma of the breast. A comparative light microscopic and morphometric study. ( 2153326 )
1990
28
Lactating adenoma of breast. ( 13049201 )
1953
29
Lactating Adenoma of Breast. ( 19987583 )
1930

Variations for Pregnancy Adenoma

Expression for Pregnancy Adenoma

Search GEO for disease gene expression data for Pregnancy Adenoma.

Pathways for Pregnancy Adenoma

Pathways related to Pregnancy Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 FGFR3 KRT14 KRT17 KRT19 KRT5 KRT7
2
Show member pathways
12.8 GNAS KRT14 KRT17 KRT19 PGR PIK3CA
3 12.21 KRT17 KRT19 KRT5 KRT7 KRT8
4
Show member pathways
11.91 A2M PLAT PLG SERPINF2
5
Show member pathways
11.89 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8
6 11.81 A2M PLAT PLG SERPINF2
7 11.58 KRT14 KRT17 KRT5
8 11.47 FGFR3 PIK3CA PTEN
9 11.3 PIK3CA PLAT PLG
10
Show member pathways
11.13 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8
11 10.77 FGFR3 PLAT
12 10.45 PLAT PLG SERPINF2

GO Terms for Pregnancy Adenoma

Cellular components related to Pregnancy Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.71 A2M PLAT PLG SERPINF2
2 extracellular exosome GO:0070062 9.7 A2M GNAS KRT14 KRT17 KRT19 KRT5
3 keratin filament GO:0045095 9.56 KRT14 KRT5 KRT7 KRT8
4 platelet alpha granule lumen GO:0031093 9.5 A2M PLG SERPINF2
5 cell periphery GO:0071944 9.46 KRT14 KRT17 KRT19 KRT8
6 intermediate filament GO:0005882 9.1 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8
7 cytosol GO:0005829 10.15 A2M GNAS KRT14 KRT17 KRT19 KRT5

Biological processes related to Pregnancy Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.58 KRT14 KRT17 KRT5
2 keratinization GO:0031424 9.43 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8
3 hemidesmosome assembly GO:0031581 9.37 KRT14 KRT5
4 fibrinolysis GO:0042730 9.33 PLAT PLG SERPINF2
5 negative regulation of fibrinolysis GO:0051918 9.32 PLG SERPINF2
6 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT19 KRT8
7 cornification GO:0070268 9.1 KRT14 KRT17 KRT19 KRT5 KRT7 KRT8

Molecular functions related to Pregnancy Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 A2M FGFR3 GNAS KRT14 KRT17 KRT19
2 structural constituent of cytoskeleton GO:0005200 8.92 KRT14 KRT17 KRT19 KRT5

Sources for Pregnancy Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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