MCID: PRM329
MIFTS: 41

Premature Aging

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Premature Aging

MalaCards integrated aliases for Premature Aging:

Name: Premature Aging 59

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

MESH via Orphanet 45 D019588
UMLS via Orphanet 73 C0231341
Orphanet 59 ORPHA79389

Summaries for Premature Aging

MalaCards based summary : Premature Aging is related to werner syndrome and rothmund-thomson syndrome. An important gene associated with Premature Aging is PDGFRB (Platelet Derived Growth Factor Receptor Beta), and among its related pathways/superpathways are DNA Damage and Regulation of Telomerase. The drugs Fluorouracil and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and bone, and related phenotypes are cardiovascular system and cellular

Wikipedia : 75 Progeroid syndromes (PS) are a group of rare genetic disorders which mimic physiological aging, making... more...

Related Diseases for Premature Aging

Diseases related to Premature Aging via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 werner syndrome 32.5 WRN LMNA BLM
2 rothmund-thomson syndrome 31.7 WRN BLM
3 hutchinson-gilford progeria syndrome 31.6 WRN LMNA
4 atypical werner syndrome 29.3 WRN LMNA
5 aging 29.2 WRN TP63 SOD2 PDGFRB LMNA
6 bloom syndrome 29.1 WRN BLM
7 premature aging syndrome, penttinen type 12.8
8 premature aging syndrome, okamoto type 12.6
9 laminopathy with premature aging 12.3
10 short stature, hearing loss, retinitis pigmentosa, and distinctive facies 12.1
11 branchiooculofacial syndrome 12.0
12 penttinen-aula syndrome 11.8
13 progeroid syndrome, penttinen type 11.7
14 cockayne syndrome 11.6
15 acrogeria, gottron type 11.4
16 ogden syndrome 11.3
17 trichothiodystrophy 1, photosensitive 11.3
18 ataxia-telangiectasia 11.3
19 dyskeratosis congenita 11.3
20 mandibuloacral dysplasia with type a lipodystrophy 11.3
21 progeroid short stature with pigmented nevi 11.3
22 nestor-guillermo progeria syndrome 11.3
23 cutis laxa, autosomal dominant 1 11.1
24 cutis laxa, autosomal recessive, type ia 11.1
25 gapo syndrome 11.1
26 geroderma osteodysplasticum 11.1
27 cerebroretinal microangiopathy with calcifications and cysts 2 11.1
28 autosomal recessive cutis laxa type iii 11.1
29 progeroid syndrome petty type 11.1
30 williams-beuren syndrome 10.9
31 cerebrooculofacioskeletal syndrome 1 10.9
32 cutis laxa, autosomal recessive, type iiia 10.9
33 cutis laxa, autosomal recessive, type iia 10.9
34 short syndrome 10.9
35 fontaine progeroid syndrome 10.9
36 cutis laxa, autosomal recessive, type ic 10.9
37 cutis laxa, autosomal dominant 2 10.9
38 cutis laxa, autosomal recessive, type ib 10.9
39 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.9
40 cutis laxa, autosomal dominant 3 10.9
41 cockayne syndrome type i 10.9
42 cockayne syndrome type ii 10.9
43 cockayne syndrome type iii 10.9
44 cataract 10.2
45 end stage renal failure 10.1
46 kidney disease 10.1
47 alopecia 10.1
48 progeroid syndrome 10.1
49 xeroderma pigmentosum, variant type 10.0
50 ataxia and polyneuropathy, adult-onset 10.0

Graphical network of the top 20 diseases related to Premature Aging:



Diseases related to Premature Aging

Symptoms & Phenotypes for Premature Aging

MGI Mouse Phenotypes related to Premature Aging:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 BLM LMNA PDGFRB SOD2 TP63 WRN
2 cellular MP:0005384 9.99 BLM LMNA PDGFRB SOD2 TP63 WRN
3 growth/size/body region MP:0005378 9.93 BLM LMNA PDGFRB SOD2 TP63 WRN
4 immune system MP:0005387 9.91 BLM LMNA PDGFRB SOD2 TP63 WRN
5 integument MP:0010771 9.88 BLM LMNA PDGFRB SOD2 TP63 WRN
6 adipose tissue MP:0005375 9.84 LMNA PDGFRB SOD2 WRN
7 craniofacial MP:0005382 9.8 LMNA PDGFRB TP63 WRN
8 mortality/aging MP:0010768 9.8 BLM LMNA PDGFRB SOD2 TP63 WRN
9 digestive/alimentary MP:0005381 9.78 LMNA PDGFRB TP63 WRN
10 limbs/digits/tail MP:0005371 9.67 LMNA PDGFRB TP63 WRN
11 neoplasm MP:0002006 9.56 BLM SOD2 TP63 WRN
12 renal/urinary system MP:0005367 9.46 LMNA PDGFRB SOD2 TP63
13 reproductive system MP:0005389 9.35 LMNA PDGFRB SOD2 TP63 WRN
14 vision/eye MP:0005391 9.02 LMNA PDGFRB SOD2 TP63 WRN

Drugs & Therapeutics for Premature Aging

Drugs for Premature Aging (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4 51-21-8 3385
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3 Dermatologic Agents Phase 4
4 Immunosuppressive Agents Phase 4
5 Immunologic Factors Phase 4
6 Antimetabolites Phase 4
7 triamcinolone acetonide Phase 4
8 Triamcinolone hexacetonide Phase 4
9 Tin Fluorides Phase 4
10 Triamcinolone diacetate Phase 4
11 Antimetabolites, Antineoplastic Phase 4
12 Integrase Inhibitors Phase 3
13 Anti-Retroviral Agents Phase 3
14 Antiviral Agents Phase 3
15 Raltegravir Potassium Phase 3
16 HIV Integrase Inhibitors Phase 3
17 Anti-HIV Agents Phase 3
18
Zoledronic Acid Approved Phase 2 118072-93-8 68740
19
Pravastatin Approved Phase 2 81093-37-0 54687
20
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 6436030 5284616 46835353
21
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
22
Lonafarnib Investigational Phase 2 193275-84-2 148195
23 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
24 Hypolipidemic Agents Phase 2
25 Lipid Regulating Agents Phase 2
26 Anticholesteremic Agents Phase 2
27 Bone Density Conservation Agents Phase 2
28 Pharmaceutical Solutions Phase 2
29 Antifungal Agents Phase 1, Phase 2
30 Anti-Bacterial Agents Phase 1, Phase 2
31 Antibiotics, Antitubercular Phase 1, Phase 2
32
Dasatinib Approved, Investigational 302962-49-8 3062316
33
Ethanol Approved 64-17-5 702
34
Angiotensin II Approved, Investigational 11128-99-7, 68521-88-0, 4474-91-3 172198
35
Valsartan Approved, Investigational 137862-53-4 60846
36
Inulin Approved, Investigational, Nutraceutical 9005-80-5 24763
37
Quercetin Experimental, Investigational 117-39-5 5280343
38 Radiation-Protective Agents
39 Sunscreening Agents
40 Anti-Inflammatory Agents
41 Omega 3 Fatty Acid
42 Sunflower
43 Antioxidants
44 Protective Agents
45 Protein Kinase Inhibitors
46 HIV Protease Inhibitors
47 Guar
48
protease inhibitors
49 Acidophilus
50 Reverse Transcriptase Inhibitors

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial Completed NCT00847912 Phase 4 5-fluorouracil;Placebo, vehicle control
2 Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Effect of Raltegravir Intensification (1.200 mg QD) on the Gut Microbiota of Chronically HIV-1 Infected Subject Over Time: THE RAGTIME Active, not recruiting NCT03029689 Phase 3 Raltegravir;Placebo;Current ART
3 A Phase II Pilot Study of Zoledronic Acid, Pravastatin, and Lonafarnib (SCH66336) for Patients With Hutchinson-Gilford Progeria Syndrome (HGPS) and Progeroid Laminopathies Completed NCT00879034 Phase 2 Lonafarnib;Zoledronic Acid;Pravastatin
4 An Open Label Dose Adjusted Phase II Trial of the Oral Farnesyltransferase Inhibitor (FTI) Lonafarnib (SCH66336) for Patients With Hutchinson-Gilford Progeria Syndrome (HGPS) and Progeroid Laminopathies Completed NCT00425607 Phase 2 Lonafarnib
5 Safety and Efficacy of Umbilical Cord Blood Transfusion in Patients With Hutchinson-Gilford Progeria Syndrome Enrolling by invitation NCT03871972 Phase 1, Phase 2 Umbilical Cord Blood Unit
6 Search for Fragility Indicators Among People Aged 50+ With Chronic HIV Infection Unknown status NCT02874118
7 Non-randomized Clinical Trial for Evaluation of the Dissector Assisted Malar Elevation in Videoendoscopic Rhytidoplasty. Unknown status NCT00925158
8 Histologic Response to UVA and UVB Exposure During the Use of Sunscreen With Anti-inflammatory and Anti-oxidant Properties - A Pilot Study Completed NCT01892150
9 Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy? Completed NCT01536808
10 The Role of Inflammation and Aging in HIV-Associated Cardiovascular Risk Completed NCT01333644
11 The Syndemic of Stress and Aging in an HIV-infected Population Completed NCT02965469
12 Assessing Performance Status in Cancer Patients Using Cardiopulmonary Exercise Testing and Wearable Data Generation: A Prospective Observational Study Completed NCT02844400
13 Pathology of Helicases and Premature Aging: Study by Derivation of hiPS Completed NCT03898817
14 Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE) Completed NCT01656421
15 Assessing Physical Fitness in Cancer Patients With Cardiopulmonary Exercise Testing and Wearable Data Generation Completed NCT02786628
16 Effectiveness of an Internet-based Mindfulness Program for Stress Management Completed NCT01595555
17 Clinical Investigations Into Hutchison-Gilford Progeria Syndrome Completed NCT00094393
18 Identification of a New Gene Involved in Hereditary Lipodystrophy - LIPOGENE Completed NCT02056912
19 Fish Oil for HIV-Related Inflamm-aging and Immune Senescence Completed NCT02102724
20 Data Collection for Identification of the Chronic Stress Presence in Healthy Adult Subjects Completed NCT02574871
21 Central Auditory Processing Deficits Associated With Blast Exposure Completed NCT01567020
22 Effects of Mindfulness Training on Chronic Inflammation in HIV-Infected Adults Completed NCT02626949
23 Evaluating the Effectiveness of Financial Incentives in Promoting Weight Loss Among Obese Individuals. Completed NCT00520611
24 Hematopoietic Stem Cell Transplant Survivors Study (HTSS Study) Recruiting NCT02652052 Quercetin;Dasatinib
25 Clinical Trial, Randomized and Controlled With Placebo to Evaluate the Addition to an Antiretroviral Treatment of a Probiotic, Only or in Conjunction of a Pre-biotical, in Adults Infected by Hiv-1 With a cd4 Record Less Than 500 Cells / mm3 Recruiting NCT03542786
26 A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer Recruiting NCT02256137
27 An Experimental Investigation Into the Impact of Socioeconomic Context on Biological Markers of Aging, Health and Mortality Active, not recruiting NCT03226548
28 Addressing Alcohol/HIV Consequences in Substance Dependence - Boston ARCH Cohort: The 4F Study Enrolling by invitation NCT03414411
29 Angiotensin Receptors and Age Related Mitochondrial Decline in HIV Patients Terminated NCT02606279 valsartan

Search NIH Clinical Center for Premature Aging

Genetic Tests for Premature Aging

Anatomical Context for Premature Aging

MalaCards organs/tissues related to Premature Aging:

41
Skin, Brain, Bone, Kidney, T Cells, Lung, Heart

Publications for Premature Aging

Articles related to Premature Aging:

(show top 50) (show all 2489)
# Title Authors PMID Year
1
Vascular smooth muscle cell loss underpins the accelerated atherosclerosis in Hutchinson-Gilford progeria syndrome. 38
30900948 2019
2
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. 38
31077852 2019
3
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging. 38
31374202 2019
4
T-cell aging in end-stage renal disease: an evolving story with CMV. 38
30903371 2019
5
Sex differences in the associations of placental epigenetic aging with fetal growth. 38
31395791 2019
6
Clinical associations with telomere length in chronic spinal cord injury. 38
31383950 2019
7
Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging. 38
31173890 2019
8
Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. 38
29493420 2019
9
Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence. 38
31421186 2019
10
Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. 38
31314053 2019
11
From stem cells protection to skin microbiota balance: Orobanche rapum extract, a new natural strategy. 38
30485658 2019
12
XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity. 38
30834581 2019
13
Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase. 38
31435650 2019
14
The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. 38
31397537 2019
15
Hutchinson-Gilford Progeria Syndrome: Cardiovascular Pathologies and Potential Therapies. 38
31036409 2019
16
Assessment of the risk and characterization of non-melanoma skin cancer in Kindler syndrome: study of a series of 91 patients. 38
31340837 2019
17
Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough? 38
31370257 2019
18
Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity. 38
31305018 2019
19
Short stature in a boy with atypical progeria syndrome due to LMNA c.433G>A [p.(Glu145Lys)]: apparent growth hormone deficiency but poor response to growth hormone therapy. 38
31199775 2019
20
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging. 38
31303548 2019
21
Restoring extracellular matrix synthesis in senescent stem cells. 38
31287964 2019
22
Multifaceted Mechanisms of Vascular Calcification in Aging. 38
31144990 2019
23
Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. 38
31291576 2019
24
Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. 38
31348603 2019
25
Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. 38
31259468 2019
26
PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD. 38
31343408 2019
27
Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging. 38
31290266 2019
28
Telomere length regulators are activated in young men after pediatric kidney transplantation compared to healthy controls and survivors of childhood cancer-A cross-sectional study. 38
31297925 2019
29
Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System. 38
31117357 2019
30
Pupillary response to light and tasks in early and late onset essential tremor patients. 38
31327629 2019
31
Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage. 38
31087730 2019
32
Oral squamous cell carcinoma arising in a patient with Werner syndrome. 38
31235391 2019
33
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. 38
30666569 2019
34
Nucleolar and Ribosomal Dysfunction-A Common Pathomechanism in Childhood Progerias? 38
31167386 2019
35
Characterization of senescence biomarkers in rheumatoid arthritis: relevance to disease progression. 38
31187337 2019
36
Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome. 38
31006814 2019
37
Chemical screen identifies a geroprotective role of quercetin in premature aging. 38
30069858 2019
38
Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite. 38
30884114 2019
39
Metabolomic profiling suggests systemic signatures of premature aging induced by Hutchinson-Gilford progeria syndrome. 38
31254107 2019
40
Th1 Biased Progressive Autoimmunity in Aged Aire-Deficient Mice Accelerated Thymic Epithelial Cell Senescence. 38
31164995 2019
41
Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction. 38
31171766 2019
42
Regulation of α-Klotho Expression by Dietary Phosphate During Growth Periods. 38
30671592 2019
43
Cardiac diseases as a predictor warning of hereditary muscle diseases. The case of laminopathies. 38
31309180 2019
44
Role of Klotho Protein in Tumor Genesis, Cancer Progression, and Prognosis in Patients with High-Grade Glioma. 38
31228703 2019
45
Premature aging among trauma survivors - The longitudinal implications of sleep disruptions on telomere length and cognitive performance. 38
31155651 2019
46
Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics. 38
31132524 2019
47
Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. 38
30930169 2019
48
Growing Old Too Fast: A Rare Case of Werner Syndrome. 38
31363425 2019
49
Telogen hair loss and androgenetic-like alopecia in GAPO syndrome. 38
30255493 2019
50
Influence of Electrical Traps on the Current Density Degradation of Inverted Perovskite Solar Cells. 38
31137552 2019

Variations for Premature Aging

Expression for Premature Aging

Search GEO for disease gene expression data for Premature Aging.

Pathways for Premature Aging

Pathways related to Premature Aging according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 WRN TP63 LMNA BLM
2 10.78 WRN BLM

GO Terms for Premature Aging

Cellular components related to Premature Aging according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 9.33 WRN STN1 BLM
2 replication fork GO:0005657 8.96 WRN BLM
3 chromosome, telomeric region GO:0000781 8.8 WRN STN1 BLM

Biological processes related to Premature Aging according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 double-strand break repair via homologous recombination GO:0000724 9.54 WRN BLM
2 protein homotetramerization GO:0051289 9.52 TP63 SOD2
3 DNA duplex unwinding GO:0032508 9.51 WRN BLM
4 telomere maintenance GO:0000723 9.49 WRN STN1
5 cell aging GO:0007569 9.48 WRN TP63
6 replication fork processing GO:0031297 9.46 WRN BLM
7 multicellular organism aging GO:0010259 9.43 WRN TP63
8 cellular metabolic process GO:0044237 9.4 WRN BLM
9 t-circle formation GO:0090656 9.37 WRN BLM
10 telomeric D-loop disassembly GO:0061820 9.26 WRN BLM
11 G-quadruplex DNA unwinding GO:0044806 9.16 WRN BLM
12 DNA synthesis involved in DNA repair GO:0000731 9.02 WRN
13 replicative cell aging GO:0001302 8.96 WRN TP63
14 aging GO:0007568 8.8 WRN TP63 PDGFRB

Molecular functions related to Premature Aging according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 single-stranded DNA binding GO:0003697 9.56 STN1 BLM
2 p53 binding GO:0002039 9.55 TP63 BLM
3 manganese ion binding GO:0030145 9.54 WRN SOD2
4 ATP-dependent DNA helicase activity GO:0004003 9.52 WRN BLM
5 DNA helicase activity GO:0003678 9.51 WRN BLM
6 four-way junction DNA binding GO:0000400 9.49 WRN BLM
7 ATP-dependent helicase activity GO:0008026 9.48 WRN BLM
8 G-quadruplex DNA binding GO:0051880 9.46 WRN BLM
9 ATP-dependent 3'-5' DNA helicase activity GO:0043140 9.43 WRN BLM
10 Y-form DNA binding GO:0000403 9.4 WRN BLM
11 bubble DNA binding GO:0000405 9.37 WRN BLM
12 four-way junction helicase activity GO:0009378 9.32 WRN BLM
13 telomeric D-loop binding GO:0061821 9.26 WRN BLM
14 telomeric G-quadruplex DNA binding GO:0061849 9.16 WRN BLM
15 8-hydroxy-2'-deoxyguanosine DNA binding GO:1905773 8.96 WRN BLM
16 forked DNA-dependent helicase activity GO:0061749 8.62 WRN BLM

Sources for Premature Aging

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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