MCID: PRM329
MIFTS: 35

Premature Aging

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Premature Aging

MalaCards integrated aliases for Premature Aging:

Name: Premature Aging 58
Syndrome with Premature-Aging 6

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

MESH via Orphanet 44 D019588
UMLS via Orphanet 72 C0231341
Orphanet 58 ORPHA79389

Summaries for Premature Aging

MalaCards based summary : Premature Aging, also known as syndrome with premature-aging, is related to hutchinson-gilford progeria syndrome and aging. An important gene associated with Premature Aging is PDGFRB (Platelet Derived Growth Factor Receptor Beta), and among its related pathways/superpathways is Neurodegenerative Diseases. The drugs Fluorouracil and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and kidney, and related phenotypes are adipose tissue and integument

Wikipedia : 74 Progeroid syndromes (PS) are a group of rare genetic disorders which mimic physiological aging, making... more...

Related Diseases for Premature Aging

Diseases related to Premature Aging via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 hutchinson-gilford progeria syndrome 31.7 SOD2 LMNA
2 aging 29.4 TP63 SOD2 PDGFRB LMNA
3 alopecia 29.1 TP63 LMNA
4 premature aging syndrome, penttinen type 12.9
5 premature aging syndrome, okamoto type 12.6
6 laminopathy with premature aging 12.4
7 short stature, hearing loss, retinitis pigmentosa, and distinctive facies 12.2
8 werner syndrome 12.2
9 branchiooculofacial syndrome 12.0
10 cockayne syndrome 11.6
11 acrogeria, gottron type 11.4
12 ogden syndrome 11.4
13 rothmund-thomson syndrome, type 2 11.3
14 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 11.3
15 trichothiodystrophy 11.3
16 ataxia-telangiectasia 11.3
17 dyskeratosis congenita 11.3
18 mandibuloacral dysplasia with type a lipodystrophy 11.3
19 progeroid short stature with pigmented nevi 11.3
20 cockayne syndrome a 11.3
21 nestor-guillermo progeria syndrome 11.3
22 geroderma osteodysplasticum 11.2
23 cutis laxa, autosomal dominant 1 11.1
24 cutis laxa, autosomal recessive, type ia 11.1
25 gapo syndrome 11.1
26 cerebroretinal microangiopathy with calcifications and cysts 2 11.1
27 autosomal recessive cutis laxa type iii 11.1
28 progeroid syndrome petty type 11.1
29 cockayne syndrome b 10.9
30 williams-beuren syndrome 10.9
31 cerebrooculofacioskeletal syndrome 1 10.9
32 cutis laxa, autosomal recessive, type iiia 10.9
33 cutis laxa, autosomal recessive, type iia 10.9
34 hallermann-streiff syndrome 10.9
35 short syndrome 10.9
36 fontaine progeroid syndrome 10.9
37 cutis laxa, autosomal recessive, type ic 10.9
38 cutis laxa, autosomal dominant 2 10.9
39 cutis laxa, autosomal recessive, type ib 10.9
40 cutis laxa, autosomal dominant 3 10.9
41 saul-wilson syndrome 10.9
42 cockayne syndrome type iii 10.9
43 cataract 10.2
44 kidney disease 10.1
45 end stage renal disease 10.1
46 xeroderma pigmentosum, variant type 10.1
47 chronic kidney disease 10.1
48 progeroid syndrome 10.1
49 ataxia and polyneuropathy, adult-onset 10.0
50 alcohol dependence 10.0

Graphical network of the top 20 diseases related to Premature Aging:



Diseases related to Premature Aging

Symptoms & Phenotypes for Premature Aging

MGI Mouse Phenotypes related to Premature Aging:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.67 LMNA NR2C2 PDGFRB SOD2
2 integument MP:0010771 9.65 LMNA NR2C2 PDGFRB SOD2 TP63
3 craniofacial MP:0005382 9.62 LMNA NR2C2 PDGFRB TP63
4 muscle MP:0005369 9.46 LMNA PDGFRB SOD2 TP63
5 renal/urinary system MP:0005367 9.26 LMNA PDGFRB SOD2 TP63
6 reproductive system MP:0005389 9.02 LMNA NR2C2 PDGFRB SOD2 TP63

Drugs & Therapeutics for Premature Aging

Drugs for Premature Aging (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4 51-21-8 3385
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
4
Polyestradiol phosphate Approved Phase 4 28014-46-2
5 Dermatologic Agents Phase 4
6 Immunologic Factors Phase 4
7 Immunosuppressive Agents Phase 4
8 Antimetabolites Phase 4
9 Tin Fluorides Phase 4
10 triamcinolone acetonide Phase 4
11 Triamcinolone diacetate Phase 4
12 Triamcinolone hexacetonide Phase 4
13 Hormones Phase 4
14 Estradiol 17 beta-cypionate Phase 4
15 Estradiol 3-benzoate Phase 4
16 Hormone Antagonists Phase 4
17 Contraceptive Agents Phase 4
18 Estrogens Phase 4
19 Integrase Inhibitors Phase 3
20 HIV Integrase Inhibitors Phase 3
21 Anti-Retroviral Agents Phase 3
22 Anti-Infective Agents Phase 3
23 Antiviral Agents Phase 3
24 Anti-HIV Agents Phase 3
25 Raltegravir Potassium Phase 3
26
Zoledronic Acid Approved Phase 2 118072-93-8 68740
27
Pravastatin Approved Phase 2 81093-37-0 54687
28
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
29
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
30
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
31
Lonafarnib Investigational Phase 2 193275-84-2 148195
32 Lipid Regulating Agents Phase 2
33 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
34 Anticholesteremic Agents Phase 2
35 Hypolipidemic Agents Phase 2
36 Pharmaceutical Solutions Phase 2
37 Anti-Bacterial Agents Phase 1, Phase 2
38 Antifungal Agents Phase 1, Phase 2
39 Antibiotics, Antitubercular Phase 1, Phase 2
40
Dasatinib Approved, Investigational 302962-49-8 3062316
41
Ethanol Approved 64-17-5 702
42
Valsartan Approved, Investigational 137862-53-4 60846
43
Angiotensin II Approved, Investigational 4474-91-3, 11128-99-7, 68521-88-0 172198
44
Inulin Approved, Investigational, Nutraceutical 9005-80-5 24763
45
Quercetin Experimental, Investigational 117-39-5 5280343
46
protease inhibitors
47 Reverse Transcriptase Inhibitors
48 Acidophilus
49 HIV Protease Inhibitors
50 Guar

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial Completed NCT00847912 Phase 4 5-fluorouracil;Placebo, vehicle control
2 The Impact of HIV on Accelerated Aging in the Female Genital Tract: a Pilot Trial of Topical Estradiol to Improve the Vaginal Microbiome and Symptoms of Vaginal Atrophy in Menopausal Women With HIV Not yet recruiting NCT04079218 Phase 4 Estradiol Vaginal Insert
3 Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Effect of Raltegravir Intensification (1.200 mg QD) on the Gut Microbiota of Chronically HIV-1 Infected Subject Over Time: THE RAGTIME Active, not recruiting NCT03029689 Phase 3 Raltegravir;Placebo;Current ART
4 A Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of DCB-AD1 in Patients With Mild to Moderate Alzheimer’s Disease Unknown status NCT00154635 Phase 2 DCB-AD1
5 A Phase II Pilot Study of Zoledronic Acid, Pravastatin, and Lonafarnib (SCH66336) for Patients With Hutchinson-Gilford Progeria Syndrome (HGPS) and Progeroid Laminopathies Completed NCT00879034 Phase 2 Lonafarnib;Zoledronic Acid;Pravastatin
6 An Open Label Dose Adjusted Phase II Trial of the Oral Farnesyltransferase Inhibitor (FTI) Lonafarnib (SCH66336) for Patients With Hutchinson-Gilford Progeria Syndrome (HGPS) and Progeroid Laminopathies Completed NCT00425607 Phase 2 Lonafarnib
7 Safety and Efficacy of Umbilical Cord Blood Transfusion in Patients With Hutchinson-Gilford Progeria Syndrome Enrolling by invitation NCT03871972 Phase 1, Phase 2 Umbilical Cord Blood Unit
8 Clinical Trial, Randomized and Controlled With Placebo to Evaluate the Addition to an Antiretroviral Treatment of a Probiotic, Only or in Conjunction of a Pre-biotical, in Adults Infected by Hiv-1 With a cd4 Record Less Than 500 Cells / mm3 Unknown status NCT03542786
9 Search for Fragility Indicators Among People Aged 50+ With Chronic HIV Infection Unknown status NCT02874118
10 Non-randomized Clinical Trial for Evaluation of the Dissector Assisted Malar Elevation in Videoendoscopic Rhytidoplasty. Unknown status NCT00925158
11 Histologic Response to UVA and UVB Exposure During the Use of Sunscreen With Anti-inflammatory and Anti-oxidant Properties - A Pilot Study Completed NCT01892150
12 Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy? Completed NCT01536808
13 The Role of Inflammation and Aging in HIV-Associated Cardiovascular Risk Completed NCT01333644
14 The Syndemic of Stress and Aging in an HIV-infected Population Completed NCT02965469
15 Assessing Physical Fitness in Cancer Patients With Cardiopulmonary Exercise Testing and Wearable Data Generation Completed NCT02786628
16 Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE) Completed NCT01656421
17 Effectiveness of an Internet-based Mindfulness Program for Stress Management Completed NCT01595555
18 Pathology of Helicases and Premature Aging: Study by Derivation of hiPS Completed NCT03898817
19 Assessing Performance Status in Cancer Patients Using Cardiopulmonary Exercise Testing and Wearable Data Generation: A Prospective Observational Study Completed NCT02844400
20 Clinical Investigations Into Hutchison-Gilford Progeria Syndrome Completed NCT00094393
21 Identification of a New Gene Involved in Hereditary Lipodystrophy - LIPOGENE Completed NCT02056912
22 Fish Oil for HIV-Related Inflamm-aging and Immune Senescence Completed NCT02102724
23 Data Collection for Identification of the Chronic Stress Presence in Healthy Adult Subjects Completed NCT02574871
24 Central Auditory Processing Deficits Associated With Blast Exposure Completed NCT01567020
25 Effects of Mindfulness Training on Chronic Inflammation in HIV-Infected Adults Completed NCT02626949
26 Evaluating the Effectiveness of Financial Incentives in Promoting Weight Loss Among Obese Individuals. Completed NCT00520611
27 Hematopoietic Stem Cell Transplant Survivors Study (HTSS Study) Recruiting NCT02652052 Quercetin;Dasatinib
28 A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer Recruiting NCT02256137
29 Efficacy of Solarplast for Health and Oxidative Stress, A Randomized, Double-Blind, Placebo-Controlled Study Recruiting NCT04144777
30 An Experimental Investigation Into the Impact of Socioeconomic Context on Biological Markers of Aging, Health and Mortality Active, not recruiting NCT03226548
31 Addressing Alcohol/HIV Consequences in Substance Dependence - Boston ARCH Cohort: The 4F Study Suspended NCT03414411
32 Angiotensin Receptors and Age Related Mitochondrial Decline in HIV Patients Terminated NCT02606279 valsartan

Search NIH Clinical Center for Premature Aging

Genetic Tests for Premature Aging

Anatomical Context for Premature Aging

MalaCards organs/tissues related to Premature Aging:

40
Skin, Brain, Kidney, Bone, T Cells, Lung, Heart

Publications for Premature Aging

Articles related to Premature Aging:

(show top 50) (show all 2638)
# Title Authors PMID Year
1
Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review). 61
32508986 2020
2
Selective chemiluminescent TURN-ON quantitative bioassay and imaging of intracellular hydrogen peroxide in human living cells. 61
32353372 2020
3
Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells. 61
32061905 2020
4
Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. 61
32209361 2020
5
Activating variants in PDGFRB result in a spectrum of disorders responsive to imatinib monotherapy. 61
32500973 2020
6
Peptide Hormone Regulation of DNA Damage Responses. 61
32270196 2020
7
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence. 61
32439659 2020
8
Brain structural correlates of trajectories to cognitive impairment in men with and without HIV disease. 61
30623289 2020
9
Increased carotid artery wall stiffness and plaque prevalence in HIV infected patients measured with ultrasound elastography. 61
32052172 2020
10
Genomics of aging: Genes, adducts, and telomeres. 61
32511191 2020
11
Extreme disruption of heterochromatin is required for accelerated hematopoietic aging. 61
32305044 2020
12
An Acromegaly Disease Zebrafish Model Reveals Decline in Body Stem Cell Number along with Signs of Premature Aging. 61
32517323 2020
13
The Similarities between Human Mitochondria and Bacteria in the Context of Structure, Genome, and Base Excision Repair System. 61
32575813 2020
14
Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure. 61
32338640 2020
15
Unique combination and in silico modeling of biallelic POLR3A variants as a cause of Wiedemann-Rautenstrauch syndrome. 61
32555393 2020
16
Evidence for Accelerated Biological Aging in Young Adults with Prader-Willi Syndrome. 61
31689713 2020
17
PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome. 61
32351002 2020
18
Accumulation of prelamin A induces premature aging through mTOR overactivation. 61
32282093 2020
19
Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson-Gilford progeria (HGPS). 61
32539085 2020
20
Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts. 61
32424227 2020
21
Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects. 61
32418119 2020
22
Shortened telomere length is associated with unfair treatment attributed to race in African Americans living in Tallahassee, Florida. 61
31867825 2020
23
Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers. 61
32471220 2020
24
Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. 61
32233025 2020
25
Development, Optimization, and Comparison of Different Sample Pre-Treatments for Simultaneous Determination of Vitamin E and Vitamin K in Vegetables. 61
32481534 2020
26
Premature Aging and Increased Risk of Adult Cardiorespiratory Disease After Extreme Preterm Birth: Getting to the Heart (and Lungs) of the Matter. 61
32407162 2020
27
Posttraumatic Stress Disorder in the Elderly. 61
32222307 2020
28
Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study. 61
31840173 2020
29
Nuclear envelope dysfunction and its contribution to the aging process. 61
32291910 2020
30
Moderation of mitochondrial respiration mitigates metabolic syndrome of aging. 61
32303655 2020
31
Novel defect in phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) at the membrane-enzyme interface is associated with metabolic cutis laxa. 61
32418222 2020
32
Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications. 61
32018037 2020
33
Molecular Mechanisms of Premature Aging in Hemodialysis: The Complex Interplay Between Innate and Adaptive Immune Dysfunction. 61
32408613 2020
34
A Case Report of Werner's Syndrome With a Novel Mutation From India. 61
32528764 2020
35
Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells. 61
32408587 2020
36
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome. 61
32450911 2020
37
Anesthetic considerations in children with Hutchinson-Gilford progeria syndrome: A narrative review. 61
32128928 2020
38
Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells. 61
32012215 2020
39
Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase. 61
32432680 2020
40
Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients. 61
32489700 2020
41
Effects of stem bark aqueous extract of Fagara tessmannii Engl (Rutaceae) on cardiovascular risks related to monosodium glutamate-induced obesity in rat: In vivo and in vitro assessments. 61
32446928 2020
42
Genetic correction of Werner syndrome gene reveals impaired pro-angiogenic function and HGF insufficiency in mesenchymal stem cells. 61
32320127 2020
43
"Just like Jail": Trauma Experiences of Older Homeless Men. 61
32116158 2020
44
DNA repair fidelity in stem cell maintenance, health, and disease. 61
30953688 2020
45
Understanding the role of p38 and JNK mediated MAPK pathway in response to UV-A induced photoaging in Caenorhabditis elegans. 61
32172136 2020
46
Beta-amyloid (Aβ) uptake by PET imaging in older HIV+ and HIV- individuals. 61
32270469 2020
47
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia. 61
32353215 2020
48
Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice. 61
32272900 2020
49
Biallelic variants in EFEMP1 in a man with a pronounced connective tissue phenotype. 61
31792352 2020
50
Hutchinson-Gilford progeria syndrome and severe aortic stenosis: a new hope for treatment. 61
32360386 2020

Variations for Premature Aging

ClinVar genetic disease variations for Premature Aging:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 VIM NM_003380.5(VIM):c.1160T>C (p.Leu387Pro)SNV Likely pathogenic 692107 10:17277319-17277319 10:17235320-17235320

Expression for Premature Aging

Search GEO for disease gene expression data for Premature Aging.

Pathways for Premature Aging

Pathways related to Premature Aging according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.29 SOD2 LMNA

GO Terms for Premature Aging

Sources for Premature Aging

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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