Aliases & Classifications for Premature Centromere Division

MalaCards integrated aliases for Premature Centromere Division:

Name: Premature Centromere Division 57 73
X-Chromosome Centromere Peculiarity 57
Pcd 57

Characteristics:

OMIM:

57
Inheritance:
isolated cases

Miscellaneous:
more commonly observed in women
associated with increasing age
pcd is a distinct disorder from premature chromatid separation (pcs, ), which occurs in all chromosomes


HPO:

32
premature centromere division:
Inheritance autosomal recessive inheritance sporadic


External Ids:

OMIM 57 212790
MedGen 42 C1859308
SNOMED-CT via HPO 69 258211005
UMLS 73 C1859308

Summaries for Premature Centromere Division

MalaCards based summary : Premature Centromere Division, also known as x-chromosome centromere peculiarity, is related to primary ciliary dyskinesia and paraneoplastic cerebellar degeneration. An important gene associated with Premature Centromere Division is PTTG1 (Pituitary Tumor-Transforming 1). Affiliated tissues include pituitary, and related phenotype is abnormality of metabolism/homeostasis.

Description from OMIM: 212790

Related Diseases for Premature Centromere Division

Graphical network of the top 20 diseases related to Premature Centromere Division:



Diseases related to Premature Centromere Division

Symptoms & Phenotypes for Premature Centromere Division

Symptoms via clinical synopsis from OMIM:

57
Laboratory Abnormalities:
premature centromere division (pcd) of the x chromosome observed in cultured lymphocytes during metaphase
pcd shows separate and rod-shaped x chromosomes without discernible centromeres
aneuploidy of the x chromosome


Clinical features from OMIM:

212790

Human phenotypes related to Premature Centromere Division:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939

Drugs & Therapeutics for Premature Centromere Division

Search Clinical Trials , NIH Clinical Center for Premature Centromere Division

Genetic Tests for Premature Centromere Division

Anatomical Context for Premature Centromere Division

MalaCards organs/tissues related to Premature Centromere Division:

41
Pituitary

Publications for Premature Centromere Division

Articles related to Premature Centromere Division:

(show all 22)
# Title Authors Year
1
A cytogenetic study of hospital workers occupationally exposed to radionuclides in Serbia: premature centromere division as novel biomarker of exposure? ( 26373643 )
2016
2
DNA damage in Alzheimer disease lymphocytes and its relation to premature centromere division. ( 23406622 )
2013
3
Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age. ( 20805239 )
2010
4
Premature centromere division of the X chromosome in neurons in Alzheimer's disease. ( 18624923 )
2008
5
Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes in Alzheimer disease patients. ( 17069875 )
2006
6
Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. ( 16049999 )
2005
7
Cell cycle and centromere FISH studies in premature centromere division. ( 16174301 )
2005
8
Prenatal diagnosis of premature centromere division-related mosaic variegated aneuploidy. ( 14755404 )
2004
9
Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle. ( 15130680 )
2004
10
Premature chromatid separation (PCS) vs. premature centromere division (PCD). ( 15098246 )
2004
11
Premature centromere division versus C-anaphases in cultures: need for consensus and guidelines. ( 14708111 )
2004
12
Prenatal diagnosis of a rare chromosomal instability syndrome: variegated aneuploidy related to premature centromere division (PCD). ( 12548747 )
2003
13
Cystic partially differentiated nephroblastoma, embryonal rhabdomyosarcoma, and multiple congenital anomalies associated with variegated mosaic aneuploidy and premature centromere division: a case report. ( 14608201 )
2003
14
Association of nonsyndromic Wilms tumor with premature centromere division (PCD). ( 12244559 )
2002
15
Variegated aneuploidy related to premature centromere division (PCD) is expressed in vivo and is a cancer-prone disease. ( 11169558 )
2001
16
Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. ( 11682618 )
2001
17
Premature centromere division in patients with multiple endocrine neoplasia type 1. ( 10087948 )
1999
18
Syndrome of microcephaly, Dandy-Walker malformation, and Wilms tumor caused by mosaic variegated aneuploidy with premature centromere division (PCD): report of a new case and review of the literature. ( 10429359 )
1999
19
The frequency of induced premature centromere division in human populations occupationally exposed to genotoxic chemicals. ( 10575433 )
1999
20
Premature centromere division in three unrelated families. ( 8766139 )
1996
21
Premature centromeric divisions and prominent telomeres in a patient with persistent mullerian duct syndrome. ( 1967991 )
1990
22
Premature centromere division (PCD): a dominantly inherited cytogenetic anomaly. ( 3653892 )
1987

Variations for Premature Centromere Division

Expression for Premature Centromere Division

Search GEO for disease gene expression data for Premature Centromere Division.

Pathways for Premature Centromere Division

GO Terms for Premature Centromere Division

Sources for Premature Centromere Division

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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