PCD
MCID: PRM290
MIFTS: 20

Premature Centromere Division (PCD)

Aliases & Classifications for Premature Centromere Division

MalaCards integrated aliases for Premature Centromere Division:

Name: Premature Centromere Division 57 70
X-Chromosome Centromere Peculiarity 57
Pcd 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
isolated cases

Miscellaneous:
more commonly observed in women
associated with increasing age
pcd is a distinct disorder from premature chromatid separation (pcs, ), which occurs in all chromosomes


HPO:

31
premature centromere division:
Inheritance autosomal recessive inheritance sporadic


External Ids:

OMIM® 57 212790
MedGen 41 C1859308
SNOMED-CT via HPO 68 258211005
UMLS 70 C1859308

Summaries for Premature Centromere Division

MalaCards based summary : Premature Centromere Division, also known as x-chromosome centromere peculiarity, is related to primary ciliary dyskinesia and paraneoplastic cerebellar degeneration. An important gene associated with Premature Centromere Division is PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin). Affiliated tissues include lung and pituitary, and related phenotype is abnormality of metabolism/homeostasis.

More information from OMIM: 212790

Related Diseases for Premature Centromere Division

Diseases related to Premature Centromere Division via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 primary ciliary dyskinesia 11.7
2 paraneoplastic cerebellar degeneration 11.4
3 ciliary dyskinesia, primary, 1 11.1
4 hyperphenylalaninemia, bh4-deficient, d 11.1
5 kartagener syndrome 11.0
6 paraneoplastic neurologic disorders 10.9
7 premature chromatid separation trait 10.4
8 alzheimer disease 10.4
9 mosaic variegated aneuploidy syndrome 1 10.4
10 roberts-sc phocomelia syndrome 10.3
11 microcephaly 10.3
12 rhabdomyosarcoma 10.2
13 chromosomal triplication 10.2
14 lung disease 10.2
15 bronchiectasis 10.2
16 otitis media 10.2
17 ataxia and polyneuropathy, adult-onset 10.2
18 retinal degeneration 10.2
19 cerebellar degeneration 10.2
20 infertility 10.1
21 colchicine resistance 10.1
22 multiple endocrine neoplasia, type i 10.1
23 hypertelorism 10.1
24 down syndrome 10.1
25 wilms tumor 1 10.1
26 fanconi anemia, complementation group a 10.1
27 alzheimer disease 5 10.1
28 mosaic variegated aneuploidy syndrome 10.1
29 oligohydramnios 10.1
30 acute leukemia 10.1
31 thrombocytopenia 10.1
32 multiple endocrine neoplasia 10.1
33 embryonal rhabdomyosarcoma 10.1
34 embryoma 10.1
35 cataract 10.1
36 esco2 spectrum disorder 10.1
37 hypotonia 10.1
38 pituitary tumors 10.1
39 male infertility 10.1
40 rhinitis 10.1
41 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.0
42 chronic rhinitis 10.0
43 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
44 retinitis pigmentosa 9.9
45 cholangitis, primary sclerosing 9.9
46 neuroretinitis 9.9
47 sclerosing cholangitis 9.9
48 retinitis 9.9
49 liver disease 9.9
50 middle ear disease 9.9

Graphical network of the top 20 diseases related to Premature Centromere Division:



Diseases related to Premature Centromere Division

Symptoms & Phenotypes for Premature Centromere Division

Human phenotypes related to Premature Centromere Division:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 31 HP:0001939

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Laboratory Abnormalities:
premature centromere division (pcd) of the x chromosome observed in cultured lymphocytes during metaphase
pcd shows separate and rod-shaped x chromosomes without discernible centromeres
aneuploidy of the x chromosome

Clinical features from OMIM®:

212790 (Updated 05-Apr-2021)

Drugs & Therapeutics for Premature Centromere Division

Search Clinical Trials , NIH Clinical Center for Premature Centromere Division

Genetic Tests for Premature Centromere Division

Anatomical Context for Premature Centromere Division

MalaCards organs/tissues related to Premature Centromere Division:

40
Lung, Pituitary

Publications for Premature Centromere Division

Articles related to Premature Centromere Division:

(show top 50) (show all 68)
# Title Authors PMID Year
1
Premature chromatid separation (PCS) vs. premature centromere division (PCD). 61 57
15098246 2004
2
A mechanism of x chromosome aneuploidy in lymphocytes of aging women. 57 61
1150269 1975
3
Premature centromere division: a mechanism of non-disjunction causing X chromosome aneuploidy in somatic cells of man. 61 57
1190734 1975
4
Aneuploidy and ageing: chromosome studies on a random sample of the population using G-banding. 57
77211 1978
5
Premature centromere division (PCD) identified in a hucul mare with reproductive difficulties. 61
31834942 2020
6
A cytogenetic study of hospital workers occupationally exposed to radionuclides in Serbia: premature centromere division as novel biomarker of exposure? 61
26373643 2016
7
Meiotic inheritance of a fungal supernumerary chromosome and its effect on sexual fertility in Nectria haematococca. 61
26399187 2015
8
Alterations of the X Chromosome in Lymphocytes of Alzheimer's Disease Patients. 61
26502819 2015
9
Skewed X-chromosome inactivation in women affected by Alzheimer's disease. 61
25159673 2015
10
DNA damage in Alzheimer disease lymphocytes and its relation to premature centromere division. 61
23406622 2013
11
Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age. 61
20805239 2010
12
Formaldehyde-induced chromosomal aberrations and apoptosis in peripheral blood lymphocytes of personnel working in pathology departments. 61
20193773 2010
13
Chronic exposure to zinc chromate induces centrosome amplification and spindle assembly checkpoint bypass in human lung fibroblasts. 61
20030412 2010
14
Diagnostic Overlap between Fanconi Anemia and the Cohesinopathies: Roberts Syndrome and Warsaw Breakage Syndrome. 61
21490908 2010
15
The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging? 61
19647374 2009
16
Premature centromere division of the X chromosome in neurons in Alzheimer's disease. 61
18624923 2008
17
Deregulated sequential motion of centromeres induced by antitumor agents may lead to genome instability in human peripheral blood lymphocytes. 61
17436406 2007
18
Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes in Alzheimer disease patients. 61
17069875 2006
19
Chronic exposure to particulate chromate induces spindle assembly checkpoint bypass in human lung cells. 61
17112237 2006
20
A 46,X,inv(Y) young woman with gonadal dysgenesis and gonadoblastoma: cytogenetics, molecular, and methylation studies. 61
16333824 2006
21
Cell cycle and centromere FISH studies in premature centromere division. 61
16174301 2005
22
Microcephaly is not mandatory for the diagnosis of mosaic variegated aneuploidy syndrome. 61
16059936 2005
23
Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. 61
16049999 2005
24
[Chromosome aberration analysis of peripheral lymphocytes in workers exposed to benzene]. 61
15211789 2004
25
Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle. 61
15130680 2004
26
Premature centromere division versus C-anaphases in cultures: need for consensus and guidelines. 61
14708111 2004
27
Prenatal diagnosis of premature centromere division-related mosaic variegated aneuploidy. 61
14755404 2004
28
Cystic partially differentiated nephroblastoma, embryonal rhabdomyosarcoma, and multiple congenital anomalies associated with variegated mosaic aneuploidy and premature centromere division: a case report. 61
14608201 2003
29
Prenatal diagnosis of a rare chromosomal instability syndrome: variegated aneuploidy related to premature centromere division (PCD). 61
12548747 2003
30
Unusual chromosome cleavage dynamic in rodent neonatal germ cells. 61
12474063 2002
31
Association of nonsyndromic Wilms tumor with premature centromere division (PCD). 61
12244559 2002
32
Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. 61
11682618 2001
33
Variegated aneuploidy related to premature centromere division (PCD) is expressed in vivo and is a cancer-prone disease. 61
11169558 2001
34
[Centromere separation and malignancy]. 61
11126679 2000
35
The frequency of induced premature centromere division in human populations occupationally exposed to genotoxic chemicals. 61
10575433 1999
36
Premature centromere division in patients with multiple endocrine neoplasia type 1. 61
10087948 1999
37
Syndrome of microcephaly, Dandy-Walker malformation, and Wilms tumor caused by mosaic variegated aneuploidy with premature centromere division (PCD): report of a new case and review of the literature. 61
10429359 1999
38
Novel chromosomal abberation in a patient with a unique sleep disorder. 61
9436739 1998
39
Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease. 61
9439658 1997
40
Objective analysis of centromere separation. 61
8786084 1996
41
Premature centromere division in three unrelated families. 61
8766139 1996
42
Sex chromosome aneuploidy and aging. 61
7565866 1995
43
Premature centromere division: a possible manifestation of chromosome instability. 61
7747791 1995
44
Chromosome aberrations in lymphocyte cultures from paracoccidioidomycosis patients. 61
7965490 1994
45
Alzheimer's disease and ageing: a chromosomal approach. 61
8440486 1993
46
Premature centromere division. 61
1427782 1992
47
Induction of premature centromere division affecting all chromosomes under culture conditions of fragile site expression. 61
1551079 1992
48
C-anaphase versus premature centromere division. 61
1959920 1991
49
Cytogenetic analysis of unfertilized human oocytes. 61
1918309 1991
50
Nonrandom chromosome changes in multiple sclerosis. 61
2260573 1990

Variations for Premature Centromere Division

Expression for Premature Centromere Division

Search GEO for disease gene expression data for Premature Centromere Division.

Pathways for Premature Centromere Division

GO Terms for Premature Centromere Division

Sources for Premature Centromere Division

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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