MCID: PRM003
MIFTS: 46

Premature Ejaculation

Categories: Mental diseases

Aliases & Classifications for Premature Ejaculation

MalaCards integrated aliases for Premature Ejaculation:

Name: Premature Ejaculation 12 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13709
ICD9CM 36 302.75
MeSH 45 D061686
NCIt 51 C94349
SNOMED-CT 69 44001008
ICD10 34 F52.4
UMLS 74 C0033038

Summaries for Premature Ejaculation

MalaCards based summary : Premature Ejaculation is related to sexual disorder and depression. An important gene associated with Premature Ejaculation is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Taste transduction. The drugs Sodium Citrate and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen within a few moments of... more...

Related Diseases for Premature Ejaculation

Diseases related to Premature Ejaculation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 sexual disorder 30.8 HTR1A PDE5A SLC6A4
2 depression 30.7 HTR1A HTR2C SLC6A4
3 alexithymia 30.3 HTR1A SLC6A4
4 anxiety 30.2 HTR1A HTR2C HTR3A SLC6A4
5 social phobia 30.0 HTR1A HTR3A SLC6A4
6 panic disorder 29.8 HTR1A HTR3A SLC6A4
7 irritable bowel syndrome 29.7 HTR3A SLC6A4
8 attention deficit-hyperactivity disorder 29.3 HTR1A HTR1B HTR2C SLC6A3 SLC6A4
9 disease of mental health 29.2 HTR1A HTR2C PDE5A SLC6A3 SLC6A4
10 impotence 10.8
11 prostatitis 10.5
12 phobic disorder 10.3 HTR1A SLC6A4
13 kleptomania 10.3 HTR1A SLC6A4
14 intermittent explosive disorder 10.2 HTR1A SLC6A4
15 body mass index quantitative trait locus 1 10.2
16 hyperthyroidism 10.2
17 agoraphobia 10.2 HTR1A SLC6A4
18 alcohol-induced mental disorder 10.2 SLC6A3 SLC6A4
19 alcoholic psychosis 10.2 SLC6A3 SLC6A4
20 pathological gambling 10.2 SLC6A3 SLC6A4
21 migraine with aura 10.2 HTR2C SLC6A4
22 oppositional defiant disorder 10.2 SLC6A3 SLC6A4
23 migraine without aura 10.2 HTR1A SLC6A4
24 prostate cancer 10.2
25 prostate cancer, hereditary, 8 10.2
26 prostate cancer, hereditary, 6 10.2
27 hypogonadotropic hypogonadism 10.2
28 varicocele 10.2
29 hypogonadism 10.2
30 hypogonadotropism 10.2
31 placental choriocarcinoma 10.1 LEP SLC6A4
32 endogenous depression 10.1 HTR1A SLC6A4
33 amphetamine abuse 10.1 HTR1B SLC6A3
34 pulmonary hypertension, primary, 1 10.1 PDE5A SLC6A4
35 cocaine dependence 10.1 SLC6A3 SLC6A4
36 rumination disorder 10.1 HTR1A HTR3A
37 conduct disorder 10.1 SLC6A3 SLC6A4
38 periodic limb movement disorder 10.1 HTR1A HTR2C SLC6A4
39 bipolar i disorder 10.1 HTR1A HTR2C SLC6A4
40 mental depression 10.1 HTR1A HTR2C SLC6A4
41 motion sickness 10.1 HTR1A HTR3A
42 fibromyalgia 10.1 HTR3A SLC6A4
43 amnestic disorder 10.0 HTR1A HTR3A
44 antisocial personality disorder 10.0 HTR1B SLC6A3 SLC6A4
45 machado-joseph disease 10.0 HTR1A SLC6A3
46 bipolar disorder 10.0 HTR1A SLC6A3 SLC6A4
47 substance abuse 10.0 HTR1B SLC6A3 SLC6A4
48 substance dependence 10.0 HTR1B SLC6A3 SLC6A4
49 hypoactive sexual desire disorder 10.0 CYP19A1 HTR1A
50 functional gastric disease 10.0 HTR3A PDE5A

Graphical network of the top 20 diseases related to Premature Ejaculation:



Diseases related to Premature Ejaculation

Symptoms & Phenotypes for Premature Ejaculation

GenomeRNAi Phenotypes related to Premature Ejaculation according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.28 HTR1A HTR3A SLC6A4
3 Decreased viability GR00402-S-2 9.28 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Premature Ejaculation:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CYP19A1 HTR1A HTR1B HTR2C HTR3A LEP
2 growth/size/body region MP:0005378 9.91 CYP19A1 HTR1B HTR2C HTR3A LEP SLC6A3
3 endocrine/exocrine gland MP:0005379 9.88 CYP19A1 HTR1B HTR3A LEP SLC6A3 SLC6A4
4 homeostasis/metabolism MP:0005376 9.87 CYP19A1 HTR1A HTR2C HTR3A LEP SLC6A3
5 adipose tissue MP:0005375 9.76 CYP19A1 HTR1B HTR2C LEP
6 integument MP:0010771 9.73 CYP19A1 HTR2C HTR3A LEP SLC6A3 SLC6A4
7 mortality/aging MP:0010768 9.7 HTR1A HTR1B HTR2C HTR3A LEP SLC6A3
8 muscle MP:0005369 9.5 CYP19A1 HTR1B HTR2C HTR3A LEP SLC6A3
9 nervous system MP:0003631 9.17 CYP19A1 HTR1A HTR2C HTR3A LEP SLC6A3

Drugs & Therapeutics for Premature Ejaculation

Drugs for Premature Ejaculation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium Citrate Approved, Investigational Phase 4,Phase 2,Phase 1 68-04-2
2
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
3
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 77-92-9 311
4 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
5 Citrate Phase 4,Phase 2,Phase 1
6 Sildenafil Citrate Phase 4,Phase 3,Phase 2,Phase 1 171599-83-0
7 Vasodilator Agents Phase 4,Phase 2,Phase 1
8 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
9
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1 137-58-6 3676
10
Clomipramine Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 303-49-1 2801
11
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
12
Prilocaine Approved Phase 3,Phase 2,Phase 1 721-50-6 4906
13
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
14
Norflurane Approved, Experimental Phase 2, Phase 3 811-97-2
15
Tamsulosin Approved, Investigational Phase 3 106133-20-4 129211
16
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
17 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Early Phase 1
18 Anesthetics Phase 3,Phase 2,Phase 1
19 Anti-Arrhythmia Agents Phase 3,Phase 2
20 Diuretics, Potassium Sparing Phase 3,Phase 2
21 Anesthetics, Local Phase 3,Phase 2,Phase 1
22 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
23 Sodium Channel Blockers Phase 3,Phase 2
24 Antidepressive Agents, Second-Generation Phase 3,Early Phase 1
25 Serotonin Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
26 Antidepressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
27 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
28 Psychotropic Drugs Phase 3,Phase 2,Phase 1,Early Phase 1
29 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
30 Serotonin Agents Phase 3,Phase 2,Phase 1,Early Phase 1
31 Antidepressive Agents, Tricyclic Phase 3,Phase 2,Phase 1
32 Adrenergic alpha-1 Receptor Antagonists Phase 3,Phase 2,Phase 1
33 Adrenergic Agents Phase 3,Phase 2,Phase 1
34 Adrenergic alpha-Antagonists Phase 3,Phase 2,Phase 1
35 Adrenergic Antagonists Phase 3,Phase 2,Phase 1
36 Protective Agents Phase 3
37 Immunologic Factors Phase 3
38 Adjuvants, Immunologic Phase 3
39 Lidocaine, Prilocaine Drug Combination Phase 3,Phase 2,Phase 1
40 Viscosupplements Phase 3
41 Cytochrome P-450 Enzyme Inhibitors Phase 3
42 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
43 Vardenafil Dihydrochloride Phase 3
44 Narcotics Phase 3
45 Analgesics Phase 3
46 Analgesics, Opioid Phase 3
47
Serotonin Investigational, Nutraceutical Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-67-9 5202
48
Silodosin Approved Phase 2 160970-54-7
49
Povidone Approved Phase 2 9003-39-8
50
Acetylcholine Approved, Investigational Phase 2 51-84-3 187

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
2 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
3 Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation Unknown status NCT02241460 Phase 3 Placebo;Promescent Lidocaine Spray
4 Glans Penis Augmentation by Hyaluronic Acid for Treatment of Premature Ejaculation Completed NCT03459833 Phase 3 Hyaluronic Acid
5 Efficacy and Safety of Paroxetine Daily Doses of 15 mg and 20 mg in the Treatment of Premature Ejaculation Completed NCT01024491 Phase 3 paroxetine;paroxetine;placebo
6 Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation Completed NCT00556478 Phase 2, Phase 3 PSD502, contains a mixture of lidocaine and prilocaine;Placebo
7 Trial of PED-1 in Male Patients With Premature Ejaculation Completed NCT01439984 Phase 3 Clomipramine
8 The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy Completed NCT01063881 Phase 3 Dapoxetine
9 A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation Completed NCT00210613 Phase 3 Dapoxetine
10 Assessment of Efficacy and Safety of UK-390,957 in Men With Premature Ejaculation Completed NCT00143117 Phase 2, Phase 3 UK-390,957
11 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00210704 Phase 3 Dapoxetine
12 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00229073 Phase 3 dapoxetine
13 Assessment Of Efficacy and Safety UK-390,957 In Men With Premature Ejaculation Completed NCT00219635 Phase 2, Phase 3 UK-390,957
14 Assessment Of Efficacy and Safety Of UK-390,957 In Men With Premature Ejaculation Completed NCT00219583 Phase 2, Phase 3 UK-390,957
15 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00211094 Phase 3 Dapoxetine
16 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation. Completed NCT00211107 Phase 3 Dapoxetine
17 Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction Completed NCT01063855 Phase 3 Placebo;Dapoxetine;PDE5I (phosphodiesterase-5 inhibitor)
18 Assessment Of Safety Of UK-390,957 Completed NCT00219609 Phase 2, Phase 3 UK-390,957
19 An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation Completed NCT01230762 Phase 3 dapoxetine
20 Effects of Proxelan Somministration in Patients With Chronic Prostatitis Recruiting NCT03629769 Phase 3 Proxelan
21 Effect of Tamsulosin on PE Compared With Paroxetine Hydrochloride Not yet recruiting NCT03879746 Phase 3 Tamsulosin;Paroxetine Hydrochloride
22 Study to Evaluate Efficacy and Safety in Male Subjects With Premature Ejaculation Terminated NCT00983736 Phase 3 Tramadol Hydrochloride;Placebo
23 Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation Terminated NCT00983151 Phase 3 Tramadol Hydrochloride & Placebo
24 A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation Unknown status NCT02571101 Phase 2 CDFR0812-15/25mg;CDFR0812-15/50mg;Condencia;CDFR0812-Placebo;Condencia-Placebo
25 Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation Unknown status NCT01798667 Phase 2 DA-8031;Placebo
26 Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation Unknown status NCT02581826 Phase 2 Silodosin;Placebo
27 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE) Completed NCT02232425 Phase 2 IX-01;Placebo
28 A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation Completed NCT00537459 Phase 2 16448
29 Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation Completed NCT01203202 Phase 2 Clomipramine
30 A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation Completed NCT01021553 Phase 2 GSK557296;GSK557296;placebo
31 Exploratory Study of Pagoclone in Men With Premature Ejaculation. Completed NCT00370981 Phase 2 pagoclone
32 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE) Completed NCT03055806 Phase 2 IX-01 400 mg;Placebo;IX-01 800 mg;IX-01 1200 mg
33 Safety, Tolerability, Pharmacokinetics and Efficacy of YHD1044 Completed NCT01419470 Phase 1, Phase 2 dapoxetine
34 PSD502 in Subjects With Premature Ejaculation Recruiting NCT03578783 Phase 2 Placebo;PSD502
35 Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery Recruiting NCT02648386 Phase 1, Phase 2
36 A Safety and Efficacy Study of OnabotulinumtoxinA in Premature Ejaculation Terminated NCT01917006 Phase 2 OnabotulinumtoxinA;Normal Saline
37 Proof of Mechanism in ELT Completed NCT00861484 Phase 1 GSK958108;Placebo
38 A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation Completed NCT01184105 Phase 1 Intervention A;Intervention B
39 FTIH Study With GSK958108 Completed NCT00664365 Phase 1 GSK958108;Placebo
40 A Safety and Tolerability Study of Administration of PSD502 Completed NCT01183208 Phase 1 Intervention A;Intervention B;Intervention C;Intervention D;Intervention E
41 A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296. Completed NCT00549211 Phase 1 GSK557296
42 Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males Completed NCT02028598 Phase 1 Treatment 1;Treatment 2;Treatment 3
43 A Pharmacodynamic Study of Dapoxetine Concomitantly Administered in Participants Taking Terazosin Completed NCT01366664 Phase 1 Treatment sequence 2;Treatment sequence 1
44 A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects Terminated NCT00449709 Phase 1 GSK221149
45 Primary Premature Ejaculation Genetics Unknown status NCT02109302 Not Applicable
46 Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation Unknown status NCT00656552 Early Phase 1 Escitalopram
47 Male Reproductive Health of Floating Population: a Large-Scale Survey in Dongguan Unknown status NCT01901029
48 Management of Sexual Dysfunction With Bioresonance Technique Unknown status NCT02028013
49 The Impact and Benefit of Physical Activity on Premature Ejaculation Completed NCT02844998 Not Applicable dapoxetine 30 mg on demand
50 Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center Research Completed NCT02572037

Search NIH Clinical Center for Premature Ejaculation

Cochrane evidence based reviews: premature ejaculation

Genetic Tests for Premature Ejaculation

Anatomical Context for Premature Ejaculation

MalaCards organs/tissues related to Premature Ejaculation:

42
Brain, Skin, Testes, Kidney, Pituitary, Thyroid

Publications for Premature Ejaculation

Articles related to Premature Ejaculation:

(show top 50) (show all 846)
# Title Authors Year
1
Are There Differences in Brain Morphology in Patients with Lifelong Premature Ejaculation? ( 31103482 )
2019
2
Correlations and stratification analysis between premature ejaculation and psychological disorders. ( 31090231 )
2019
3
Low serum vitamin D is associated with an increased likelihood of acquired premature ejaculation. ( 31063279 )
2019
4
Traditional Chinese medicine on treating premature ejaculation: A systematic review and meta-analysis. ( 31045785 )
2019
5
Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation. ( 31029436 )
2019
6
Prevalence of premature ejaculation and its impact on the quality of life: Results from a sample of Egyptian patients. ( 31025424 )
2019
7
Safety and efficacy characteristics of oral drugs in patients with premature ejaculation: a Bayesian network meta-analysis of randomized controlled trials. ( 31024113 )
2019
8
YouTube as a source of premature ejaculation. ( 31000448 )
2019
9
Topical Agents for Premature Ejaculation: A Review. ( 30987933 )
2019
10
Pelvic floor muscle training improves erectile dysfunction and premature ejaculation: a systematic review. ( 30979506 )
2019
11
Anatomic Basis and Clinical Effect of Selective Dorsal Neurectomy for Patients with Lifelong Premature Ejaculation: A Randomized Controlled Trial. ( 30935469 )
2019
12
Ten-Year Interval Changes in the Prevalence of Self-Identified Premature Ejaculation and Premature Ejaculation Based on an Estimated Intravaginal Ejaculation Latency Time of <3 Minutes in the General Population: The Korean Internet Sexuality Survey (KISS) 2016. ( 30935468 )
2019
13
Erectile Dysfunction and Premature Ejaculation in Homosexual and Heterosexual Men: A Systematic Review and Meta-Analysis of Comparative Studies. ( 30926517 )
2019
14
Premature ejaculation: an update on definition and pathophysiology. ( 30860082 )
2019
15
Sildenafil/Viagra in the treatment of premature ejaculation. ( 30837718 )
2019
16
Content Validity of the Premature Ejaculation Profile, Original and Per-Event Formats, in Men with Lifelong Premature Ejaculation. ( 30833147 )
2019
17
Efficacy of Sphincter Control Training (SCT) in the treatment of premature ejaculation, a new cognitive behavioral approach: A parallel-group randomized, controlled trial. ( 30807583 )
2019
18
Effect of premature ejaculation desensitisation therapy combined with dapoxetine hydrochloride on the treatment of primary premature ejaculation. ( 30788869 )
2019
19
Effectiveness and safety of fluoxetine for premature ejaculation: Protocol for a systematic review. ( 30762772 )
2019
20
Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED Study. ( 30705437 )
2019
21
Effectiveness comparisons of acupuncture for premature ejaculation: Protocol for a network meta-analysis. ( 30702567 )
2019
22
Differences between ICD-11 MMS and DSM-5 definition of premature ejaculation: a continuation of historical inadequacies and a source of serious misinterpretation by some European Regulatory Agencies (PART 2). ( 30659291 )
2019
23
Surgical treatment for primary premature ejaculation with an inner condom technique. ( 30653133 )
2019
24
Efficacy and safety of behavioral therapy for premature ejaculation: Protocol for a systematic review. ( 30653115 )
2019
25
Method and design of drug treatment research of subjective premature ejaculation in men differs from that of lifelong premature ejaculation in males: proposal for a new objective measure (part 1). ( 30647430 )
2019
26
Pharmacokinetics, Safety, and Tolerability of Multiple Doses of the Novel Oxytocin Receptor Antagonist Cligosiban in Development for Premature Ejaculation: Two Randomized Clinical Trials in Healthy Subjects. ( 30612858 )
2019
27
Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study. ( 30610210 )
2019
28
Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis. ( 30606186 )
2019
29
Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature Ejaculation. ( 30588783 )
2019
30
Efficacy and Safety of On Demand Clomipramine for the Treatment of Premature Ejaculation: A Multicenter, Randomized, Double-Blind, Phase III Clinical Trial. ( 30086277 )
2019
31
Novel Treatment for Premature Ejaculation in the Light of Currently Used Therapies: A Review. ( 30057136 )
2019
32
Effects of the dopamine D3 receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model. ( 29369372 )
2018
33
Tolerability and adequate therapeutic dosage of oral clomipramine for the treatment of premature ejaculation: A randomized, double-blind, placebo-controlled, fixed-dose, parallel-grouped clinical study. ( 29203842 )
2018
34
Re: Re: Karabakan M, Bozkurt A, Hirik E, Celebi B, Akdemir S, Guzel O, Nuhoglu B. The prevalence of premature ejaculation in young Turkish men. Andrologia 2016; 24: 1-5. ( 29336072 )
2018
35
Visceral adiposity index is associated with premature ejaculation inversely: a cross-sectional study. ( 29338524 )
2018
36
Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction. ( 29405168 )
2018
37
The relationship between female sexual function index domains and premature ejaculation. ( 29497891 )
2018
38
Efficacy and safety of daily use of tadalafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 29527702 )
2018
39
No effect of abstinence time on nerve electrophysiological test in premature ejaculation patients. ( 29600795 )
2018
40
The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study. ( 29633800 )
2018
41
Premature Ejaculation Among Italian Men: Prevalence and Clinical Correlates From an Observational, Non-Interventional, Cross-Sectional, Epidemiological Study (IPER). ( 29803639 )
2018
42
The Efficacy and Safety of On-demand Tramadol and Paroxetine Use in Treatment of Life Long Premature Ejaculation: A Randomized Double-blind Placebo-controlled Clinical Trial. ( 29850442 )
2018
43
Acquired premature ejaculation in Parkinson's disease and possible mechanisms. ( 29855551 )
2018
44
A Randomized Double-blind Placebo-controlled Trial to Assess the Effect of Tamarind seed in Premature Ejaculation. ( 29862208 )
2018
45
Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. ( 28730747 )
2018
46
Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study. ( 28736888 )
2018
47
Where do we come from and where are we going in the treatment of premature ejaculation? ( 28919100 )
2018
48
Sexual Cognitions, Trait Anxiety, Sexual Anxiety, and Distress in Men With Different Subtypes of Premature Ejaculation and in Their Partners. ( 29161211 )
2018
49
Circumcision does not have effect on premature ejaculation: A systematic review and meta-analysis. ( 28653427 )
2018
50
Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 28497478 )
2018

Variations for Premature Ejaculation

Expression for Premature Ejaculation

Search GEO for disease gene expression data for Premature Ejaculation.

Pathways for Premature Ejaculation

GO Terms for Premature Ejaculation

Cellular components related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.73 HTR1A HTR1B HTR2C HTR3A SLC6A3 SLC6A4
2 integral component of postsynaptic membrane GO:0099055 9.33 HTR3A SLC6A3 SLC6A4
3 serotonergic synapse GO:0099154 8.96 HTR1B SLC6A4
4 integral component of presynaptic membrane GO:0099056 8.92 HTR1B HTR3A SLC6A3 SLC6A4

Biological processes related to Premature Ejaculation according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.76 HTR1B HTR2C SLC6A3 SLC6A4
2 chemical synaptic transmission GO:0007268 9.71 HTR1A HTR1B HTR2C HTR3A
3 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.61 HTR1A HTR1B HTR2C
4 cellular response to retinoic acid GO:0071300 9.58 LEP SLC6A4
5 neurotransmitter transport GO:0006836 9.58 SLC6A3 SLC6A4
6 feeding behavior GO:0007631 9.57 HTR1B HTR2C
7 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.56 HTR1A HTR1B
8 response to ethanol GO:0045471 9.56 HTR1B HTR3A LEP SLC6A3
9 behavioral fear response GO:0001662 9.55 HTR1A HTR2C
10 neurotransmitter biosynthetic process GO:0042136 9.54 SLC6A3 SLC6A4
11 regulation of behavior GO:0050795 9.51 HTR1A HTR1B
12 response to cocaine GO:0042220 9.5 HTR1B HTR3A SLC6A3
13 regulation of dopamine metabolic process GO:0042053 9.49 HTR1A SLC6A3
14 monoamine transport GO:0015844 9.48 SLC6A3 SLC6A4
15 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.37 HTR1A HTR1B
16 vasoconstriction GO:0042310 9.33 HTR1A HTR1B SLC6A4
17 behavior GO:0007610 9.13 HTR1A HTR1B HTR2C
18 serotonin receptor signaling pathway GO:0007210 8.8 HTR1A HTR2C HTR3A
19 signal transduction GO:0007165 10 HTR1A HTR1B HTR2C HTR3A LEP PDE5A

Molecular functions related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.43 HTR1B HTR2C SLC6A3
2 neurotransmitter:sodium symporter activity GO:0005328 9.37 SLC6A3 SLC6A4
3 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR1B HTR2C
4 monoamine transmembrane transporter activity GO:0008504 9.32 SLC6A3 SLC6A4
5 G protein-coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR1B HTR2C
6 serotonin binding GO:0051378 9.02 HTR1A HTR1B HTR2C HTR3A SLC6A4

Sources for Premature Ejaculation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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