MCID: PRM003
MIFTS: 47

Premature Ejaculation

Categories: Mental diseases

Aliases & Classifications for Premature Ejaculation

MalaCards integrated aliases for Premature Ejaculation:

Name: Premature Ejaculation 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13709
ICD10 33 F52.4
ICD9CM 35 302.75
MeSH 44 D061686
NCIt 50 C94349
SNOMED-CT 68 44001008
UMLS 73 C0033038

Summaries for Premature Ejaculation

MalaCards based summary : Premature Ejaculation is related to depression and sexual disorder. An important gene associated with Premature Ejaculation is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Taste transduction. The drugs Tadalafil and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include prostate, cervix and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual... more...

Related Diseases for Premature Ejaculation

Diseases related to Premature Ejaculation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 depression 30.7 HTR1A HTR2C SLC6A4
2 sexual disorder 30.3 HTR1A PDE5A SLC6A4
3 social phobia 30.1 HTR1A HTR3A SLC6A4
4 anxiety 29.9 COMT HTR1A HTR2C HTR3A SLC6A4
5 irritable bowel syndrome 29.8 HTR3A SLC6A4
6 alexithymia 29.7 COMT HTR1A SLC6A4
7 panic disorder 29.2 COMT HTR1A HTR2C HTR3A SLC6A4
8 attention deficit-hyperactivity disorder 29.1 COMT HTR1A HTR1B HTR2C SLC6A3 SLC6A4
9 disease of mental health 29.0 COMT HTR1A HTR2C PDE5A SLC6A3 SLC6A4
10 impotence 10.8
11 prostatitis 10.5
12 body mass index quantitative trait locus 1 10.2
13 hyperthyroidism 10.2
14 prostate cancer 10.2
15 hypogonadotropic hypogonadism 10.2
16 varicocele 10.2
17 hypogonadism 10.2
18 kleptomania 10.2 HTR1A SLC6A4
19 intermittent explosive disorder 10.1 HTR1A SLC6A4
20 agoraphobia 10.1 HTR1A SLC6A4
21 alcohol-induced mental disorder 10.1 SLC6A3 SLC6A4
22 alcoholic psychosis 10.1 SLC6A3 SLC6A4
23 pathological gambling 10.1 SLC6A3 SLC6A4
24 migraine without aura 10.1 HTR1A SLC6A4
25 placental choriocarcinoma 10.1 LEP SLC6A4
26 endogenous depression 10.1 HTR1A SLC6A4
27 amphetamine abuse 10.1 HTR1B SLC6A3
28 periodic limb movement disorder 10.1 HTR1A HTR2C SLC6A4
29 rumination disorder 10.1 HTR1A HTR3A
30 cocaine dependence 10.1 SLC6A3 SLC6A4
31 pulmonary hypertension, primary, 1 10.1 PDE5A SLC6A4
32 motion sickness 10.1 HTR1A HTR3A
33 amnestic disorder 10.0 HTR1A HTR3A
34 machado-joseph disease 10.0 HTR1A SLC6A3
35 substance dependence 10.0 HTR1B SLC6A3 SLC6A4
36 functional gastric disease 10.0 HTR3A PDE5A
37 paranoid schizophrenia 10.0 COMT SLC6A4
38 serotonin syndrome 10.0 HTR1A HTR3A SLC6A4
39 dyspepsia 10.0 HTR1A HTR3A SLC6A4
40 pulmonary hypertension 9.9 HTR1B PDE5A SLC6A4
41 postpartum depression 9.9 COMT SLC6A4
42 sudden infant death syndrome 9.9 HTR1A HTR3A SLC6A4
43 spondyloarthropathy 1 9.9
44 hypogonadotropic hypogonadism 7 with or without anosmia 9.9
45 prostatic hyperplasia, benign 9.9
46 peyronie's disease 9.9
47 brain injury 9.9
48 diabetes mellitus 9.9
49 traumatic brain injury 9.9
50 impulse control disorder 9.9

Graphical network of the top 20 diseases related to Premature Ejaculation:



Diseases related to Premature Ejaculation

Symptoms & Phenotypes for Premature Ejaculation

GenomeRNAi Phenotypes related to Premature Ejaculation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.28 HTR1A HTR3A SLC6A4
3 Decreased viability GR00402-S-2 9.28 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Premature Ejaculation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 COMT HTR1A HTR1B HTR2C HTR3A LEP
2 homeostasis/metabolism MP:0005376 9.87 COMT HTR1A HTR2C HTR3A LEP SLC6A3
3 endocrine/exocrine gland MP:0005379 9.85 COMT HTR1B HTR3A LEP SLC6A3 SLC6A4
4 mortality/aging MP:0010768 9.7 HTR1A HTR1B HTR2C HTR3A LEP SLC6A3
5 integument MP:0010771 9.65 HTR2C HTR3A LEP SLC6A3 SLC6A4
6 muscle MP:0005369 9.43 HTR1B HTR2C HTR3A LEP SLC6A3 SLC6A4
7 nervous system MP:0003631 9.17 COMT HTR1A HTR2C HTR3A LEP SLC6A3

Drugs & Therapeutics for Premature Ejaculation

Drugs for Premature Ejaculation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 77-92-9 311
3 Sildenafil Citrate Phase 4,Phase 3,Phase 2,Phase 1 171599-83-0
4 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
5 Vasodilator Agents Phase 4,Phase 2,Phase 1
6 Citrate Phase 4,Phase 2,Phase 1
7 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
8
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1 137-58-6 3676
9
Clomipramine Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 303-49-1 2801
10
Prilocaine Approved Phase 3,Phase 2,Phase 1 721-50-6 4906
11
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
12
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
13
Norflurane Approved, Experimental Phase 2, Phase 3 811-97-2
14
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
15 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
16 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Early Phase 1
17 Anti-Arrhythmia Agents Phase 3,Phase 2
18 Anesthetics, Local Phase 3,Phase 2,Phase 1
19 Diuretics, Potassium Sparing Phase 3,Phase 2
20 Anesthetics Phase 3,Phase 2,Phase 1
21 Sodium Channel Blockers Phase 3,Phase 2
22 Serotonin Agents Phase 3,Phase 2,Phase 1,Early Phase 1
23 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
24 Antidepressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
25 Psychotropic Drugs Phase 3,Phase 2,Phase 1,Early Phase 1
26 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antidepressive Agents, Second-Generation Phase 3,Early Phase 1
28 Serotonin Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
29 Antidepressive Agents, Tricyclic Phase 3,Phase 2,Phase 1
30 Viscosupplements Phase 3
31 Adjuvants, Immunologic Phase 3
32 Immunologic Factors Phase 3
33 EMLA Phase 3,Phase 2,Phase 1
34 Protective Agents Phase 3
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
37 Vardenafil Dihydrochloride Phase 3
38 Analgesics, Opioid Phase 3
39 Analgesics Phase 3
40 Narcotics Phase 3
41
Serotonin Investigational, Nutraceutical Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-67-9 5202
42
Silodosin Approved Phase 2 160970-54-7
43
Povidone Approved Phase 2 9003-39-8
44
Acetylcholine Approved Phase 2 51-84-3 187
45 Adrenergic alpha-1 Receptor Antagonists Phase 2,Phase 1
46 Adrenergic alpha-Antagonists Phase 2,Phase 1
47 Adrenergic Antagonists Phase 2,Phase 1
48 Adrenergic Agents Phase 2,Phase 1
49 Cholinergic Agents Phase 2,Early Phase 1
50 Anti-Infective Agents Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 63)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
2 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
3 Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation Unknown status NCT02241460 Phase 3 Placebo;Promescent Lidocaine Spray
4 Glans Penis Augmentation by Hyaluronic Acid for Treatment of Premature Ejaculation Completed NCT03459833 Phase 3 Hyaluronic Acid
5 Efficacy and Safety of Paroxetine Daily Doses of 15 mg and 20 mg in the Treatment of Premature Ejaculation Completed NCT01024491 Phase 3 paroxetine;paroxetine;placebo
6 Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation Completed NCT00556478 Phase 2, Phase 3 PSD502, contains a mixture of lidocaine and prilocaine;Placebo
7 Trial of PED-1 in Male Patients With Premature Ejaculation Completed NCT01439984 Phase 3 Clomipramine
8 The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy Completed NCT01063881 Phase 3 Dapoxetine
9 A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation Completed NCT00210613 Phase 3 Dapoxetine
10 Assessment of Efficacy and Safety of UK-390,957 in Men With Premature Ejaculation Completed NCT00143117 Phase 2, Phase 3 UK-390,957
11 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00210704 Phase 3 Dapoxetine
12 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00229073 Phase 3 dapoxetine
13 Assessment Of Efficacy and Safety UK-390,957 In Men With Premature Ejaculation Completed NCT00219635 Phase 2, Phase 3 UK-390,957
14 Assessment Of Efficacy and Safety Of UK-390,957 In Men With Premature Ejaculation Completed NCT00219583 Phase 2, Phase 3 UK-390,957
15 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00211094 Phase 3 Dapoxetine
16 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation. Completed NCT00211107 Phase 3 Dapoxetine
17 Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction Completed NCT01063855 Phase 3 Placebo;Dapoxetine;PDE5I (phosphodiesterase-5 inhibitor)
18 Assessment Of Safety Of UK-390,957 Completed NCT00219609 Phase 2, Phase 3 UK-390,957
19 An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation Completed NCT01230762 Phase 3 dapoxetine
20 Effects of Proxelan Somministration in Patients With Chronic Prostatitis Recruiting NCT03629769 Phase 3 Proxelan
21 Study to Evaluate Efficacy and Safety in Male Subjects With Premature Ejaculation Terminated NCT00983736 Phase 3 Tramadol Hydrochloride;Placebo
22 Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation Terminated NCT00983151 Phase 3 Tramadol Hydrochloride & Placebo
23 A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation Unknown status NCT02571101 Phase 2 CDFR0812-15/25mg;CDFR0812-15/50mg;Condencia;CDFR0812-Placebo;Condencia-Placebo
24 Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation Unknown status NCT01798667 Phase 2 DA-8031;Placebo
25 Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation Unknown status NCT02581826 Phase 2 Silodosin;Placebo
26 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE) Completed NCT02232425 Phase 2 IX-01;Placebo
27 A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation Completed NCT00537459 Phase 2 16448
28 Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation Completed NCT01203202 Phase 2 Clomipramine
29 A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation Completed NCT01021553 Phase 2 GSK557296;GSK557296;placebo
30 Exploratory Study of Pagoclone in Men With Premature Ejaculation. Completed NCT00370981 Phase 2 pagoclone
31 Safety, Tolerability, Pharmacokinetics and Efficacy of YHD1044 Completed NCT01419470 Phase 1, Phase 2 dapoxetine
32 PSD502 in Subjects With Premature Ejaculation Recruiting NCT03578783 Phase 2 Placebo;PSD502
33 Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery Recruiting NCT02648386 Phase 1, Phase 2
34 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE) Active, not recruiting NCT03055806 Phase 2 IX-01 400 mg;Placebo;IX-01 800 mg;IX-01 1200 mg
35 A Safety and Efficacy Study of OnabotulinumtoxinA in Premature Ejaculation Terminated NCT01917006 Phase 2 OnabotulinumtoxinA;Normal Saline
36 Proof of Mechanism in ELT Completed NCT00861484 Phase 1 GSK958108;Placebo
37 A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation Completed NCT01184105 Phase 1 Intervention A;Intervention B
38 FTIH Study With GSK958108 Completed NCT00664365 Phase 1 GSK958108;Placebo
39 A Safety and Tolerability Study of Administration of PSD502 Completed NCT01183208 Phase 1 Intervention A;Intervention B;Intervention C;Intervention D;Intervention E
40 A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296. Completed NCT00549211 Phase 1 GSK557296
41 Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males Completed NCT02028598 Phase 1 Treatment 1;Treatment 2;Treatment 3
42 A Pharmacodynamic Study of Dapoxetine Concomitantly Administered in Participants Taking Terazosin Completed NCT01366664 Phase 1 Treatment sequence 2;Treatment sequence 1
43 A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects Terminated NCT00449709 Phase 1 GSK221149
44 Primary Premature Ejaculation Genetics Unknown status NCT02109302 Not Applicable
45 Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation Unknown status NCT00656552 Early Phase 1 Escitalopram
46 Male Reproductive Health of Floating Population: a Large-Scale Survey in Dongguan Unknown status NCT01901029
47 Management of Sexual Dysfunction With Bioresonance Technique Unknown status NCT02028013
48 The Impact and Benefit of Physical Activity on Premature Ejaculation Completed NCT02844998 Not Applicable dapoxetine 30 mg on demand
49 Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center Research Completed NCT02572037
50 Effect of Exercise on Premature Ejaculation Completed NCT02984592

Search NIH Clinical Center for Premature Ejaculation

Cochrane evidence based reviews: premature ejaculation

Genetic Tests for Premature Ejaculation

Anatomical Context for Premature Ejaculation

MalaCards organs/tissues related to Premature Ejaculation:

41
Prostate, Cervix, Brain, Skin, Testes, Heart, Kidney

Publications for Premature Ejaculation

Articles related to Premature Ejaculation:

(show top 50) (show all 819)
# Title Authors Year
1
Pharmacological interventions for premature ejaculation: a mixed-treatment comparison network meta-analysis of randomized clinical trials. ( 29921893 )
2018
2
The Efficacy and Safety of On-demand Tramadol and Paroxetine Use in Treatment of Life Long Premature Ejaculation: A Randomized Double-blind Placebo-controlled Clinical Trial. ( 29850442 )
2018
3
Re: Re: Karabakan M, Bozkurt A, Hirik E, Celebi B, Akdemir S, Guzel O, Nuhoglu B. The prevalence of premature ejaculation in young Turkish men. Andrologia 2016; 24: 1-5. ( 29336072 )
2018
4
The relationship between female sexual function index domains and premature ejaculation. ( 29497891 )
2018
5
Acquired premature ejaculation in Parkinson's disease and possible mechanisms. ( 29855551 )
2018
6
No effect of abstinence time on nerve electrophysiological test in premature ejaculation patients. ( 29600795 )
2018
7
Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation: long-term outcomes. ( 29974885 )
2018
8
Do we have put a new cornerstone for the treatment of premature ejaculation? ( 29930264 )
2018
9
Premature Ejaculation Among Italian Men: Prevalence and ClinicalA Correlates From an Observational, Non-Interventional, Cross-Sectional, Epidemiological Study (IPER). ( 29803639 )
2018
10
Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response. ( 29952430 )
2018
11
Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction. ( 29405168 )
2018
12
Effects of the dopamine D<sub>3</sub>receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model. ( 29369372 )
2018
13
The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study. ( 29633800 )
2018
14
Visceral adiposity index is associated with premature ejaculation inversely: a cross-sectional study. ( 29338524 )
2018
15
Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients. ( 29872385 )
2018
16
Efficacy and safety of daily use of tadalafil in treatment ofA patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 29527702 )
2018
17
A Randomized Double-blind Placebo-controlled Trial to Assess the Effect of Tamarind seed in Premature Ejaculation. ( 29862208 )
2018
18
Possible role of serum testosterone, gonadotropins and prolactin in patients with premature ejaculation. ( 28439908 )
2018
19
Short- and long-range synergism disorders in lifelong premature ejaculation evaluated using the functional connectivity density and network property. ( 29984168 )
2018
20
Serotonin transporter (5-HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation. ( 30019487 )
2018
21
Drug treatment options for premature ejaculation. ( 30028639 )
2018
22
Novel Treatment for Premature Ejaculation in the Light of Currently Used Therapies: A Review. ( 30057136 )
2018
23
Practice Patterns Among Korean Urologists for Glans Penis Augmentation Using Hyaluronic Acid Filler in the Management of Premature Ejaculation. ( 30078733 )
2018
24
Efficacy and Safety of On-Demand Clomipramine for the Treatment of Premature Ejaculation: A Multicenter, Randomized, Double-Blind, Phase III Clinical Trial. ( 30086277 )
2018
25
General and sex profile of women with partner affected by premature ejaculation: results of a large observational, non-interventional, cross-sectional, epidemiological study (IPER-F). ( 30120814 )
2018
26
Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study. ( 30155606 )
2018
27
Acupuncture for premature ejaculation: Protocol for a systematic review. ( 30170398 )
2018
28
Abnormal White Matter Microstructure in Lifelong Premature Ejaculation Patients Identified by Tract-Based Spatial Statistical Analysis. ( 30224018 )
2018
29
Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis. ( 30225547 )
2018
30
Editorial to the paper entitled "pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis". ( 30242547 )
2018
31
5HT-1A receptor polymorphism effects ejaculatory function in Egyptian patients with lifelong premature ejaculation. ( 30266578 )
2018
32
Dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized controlled trials with trial sequential analysis. ( 30284992 )
2018
33
Milnacipran for Postcoital Cephalgia and Premature Ejaculation. ( 30299272 )
2018
34
Erratum: A Randomized Double-blind Placebo-controlled Trial to Assess the Effect of Tamarind seed in Premature Ejaculation. ( 30310778 )
2018
35
Pharmacokinetics, Safety, and Tolerability of Single Oral Doses of a Novel Oxytocin Receptor Antagonist-Cligosiban-in Development for Premature Ejaculation: Three Randomized Clinical Trials in Healthy Subjects. ( 30341006 )
2018
36
Acellular dermal matrix in premature ejaculation: A preliminary study. ( 30407339 )
2018
37
Premature ejaculation in primary care: communication strategies versus usual care for male patients consulting for a sexual, urogenital or psychological reason - GET UP: study protocol for a cluster randomised controlled trial. ( 30419940 )
2018
38
Comparative efficacy and safety of phosphodiesterase-5 inhibitors with selective serotonin reuptake inhibitors in men with premature ejaculation: A systematic review and Bayesian network meta-analysis. ( 30544399 )
2018
39
Clinical characteristics of men complaining of premature ejaculation together with erectile dysfunction: a cross-sectional study. ( 30556353 )
2018
40
Association between polymorphisms in the human serotonin transporter gene and lifelong premature ejaculation in the Han population. ( 28139473 )
2018
41
Impact of physical activity on patient self-reported outcomes of lifelong premature ejaculation patients: Results of a prospective, randomised, sham-controlled trial. ( 28261848 )
2018
42
Validity of premature ejaculation diagnostic tool and its association with International Index of Erectile Function-15 in Chinese men with evidence-based-defined premature ejaculation. ( 28361812 )
2018
43
Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study. ( 28736888 )
2017
44
Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 28497478 )
2017
45
The prevalence of an excessive prepuce and the effects of distal circumcision on premature ejaculation. ( 29071143 )
2017
46
Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. ( 28627033 )
2017
47
Phosphodiesterase-5 inhibitors for premature ejaculation: a systematic review and meta-analysis. ( 28702510 )
2017
48
Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism. ( 27679962 )
2017
49
A case report of over-the-counter codeine dependence as consequence of self-medication for premature ejaculation. ( 29564281 )
2017
50
Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going. ( 27704632 )
2017

Variations for Premature Ejaculation

Expression for Premature Ejaculation

Search GEO for disease gene expression data for Premature Ejaculation.

Pathways for Premature Ejaculation

GO Terms for Premature Ejaculation

Cellular components related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.95 COMT HTR1A HTR1B HTR2C HTR3A SLC6A3
2 integral component of plasma membrane GO:0005887 9.73 HTR1A HTR1B HTR2C HTR3A SLC6A3 SLC6A4
3 dendrite GO:0030425 9.62 COMT HTR1A HTR1B HTR2C
4 axon GO:0030424 9.54 COMT HTR3A SLC6A3
5 integral component of postsynaptic membrane GO:0099055 9.33 HTR3A SLC6A3 SLC6A4
6 serotonergic synapse GO:0099154 8.96 HTR1B SLC6A4
7 integral component of presynaptic membrane GO:0099056 8.92 HTR1B HTR3A SLC6A3 SLC6A4

Biological processes related to Premature Ejaculation according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.73 HTR1A HTR1B HTR2C HTR3A
2 response to drug GO:0042493 9.65 COMT HTR1B HTR2C SLC6A3 SLC6A4
3 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.63 HTR1A HTR1B HTR2C
4 response to ethanol GO:0045471 9.62 HTR1B HTR3A LEP SLC6A3
5 cellular response to retinoic acid GO:0071300 9.59 LEP SLC6A4
6 neurotransmitter transport GO:0006836 9.58 SLC6A3 SLC6A4
7 feeding behavior GO:0007631 9.58 HTR1B HTR2C
8 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.57 HTR1A HTR1B
9 behavioral fear response GO:0001662 9.56 HTR1A HTR2C
10 neurotransmitter biosynthetic process GO:0042136 9.55 SLC6A3 SLC6A4
11 response to cocaine GO:0042220 9.54 HTR1B HTR3A SLC6A3
12 regulation of behavior GO:0050795 9.52 HTR1A HTR1B
13 regulation of dopamine metabolic process GO:0042053 9.51 HTR1A SLC6A3
14 monoamine transport GO:0015844 9.49 SLC6A3 SLC6A4
15 dopamine catabolic process GO:0042420 9.48 COMT SLC6A3
16 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.4 HTR1A HTR1B
17 vasoconstriction GO:0042310 9.33 HTR1A HTR1B SLC6A4
18 behavior GO:0007610 9.13 HTR1A HTR1B HTR2C
19 serotonin receptor signaling pathway GO:0007210 8.8 HTR1A HTR2C HTR3A
20 signal transduction GO:0007165 10.01 HTR1A HTR1B HTR2C HTR3A LEP PDE5A

Molecular functions related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.43 HTR1B HTR2C SLC6A3
2 neurotransmitter:sodium symporter activity GO:0005328 9.37 SLC6A3 SLC6A4
3 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR1B HTR2C
4 monoamine transmembrane transporter activity GO:0008504 9.32 SLC6A3 SLC6A4
5 G protein-coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR1B HTR2C
6 serotonin binding GO:0051378 9.02 HTR1A HTR1B HTR2C HTR3A SLC6A4

Sources for Premature Ejaculation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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