MCID: PRM003
MIFTS: 47

Premature Ejaculation

Categories: Mental diseases

Aliases & Classifications for Premature Ejaculation

Summaries for Premature Ejaculation

MalaCards based summary : Premature Ejaculation is related to sexual disorder and social phobia. An important gene associated with Premature Ejaculation is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Taste transduction. The drugs Tadalafil and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual... more...

Related Diseases for Premature Ejaculation

Diseases related to Premature Ejaculation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 sexual disorder 30.1 HTR1A PDE5A
2 social phobia 29.8 HTR1A HTR3A SLC6A4
3 depression 29.6 HTR1A HTR2C HTR3A SLC6A4
4 irritable bowel syndrome 29.4 HTR3A SLC6A4
5 alexithymia 29.2 COMT HTR1A SLC6A4
6 anxiety 28.2 COMT HTR1A HTR2C HTR3A SLC6A4
7 panic disorder 27.5 COMT HTR1A HTR2C HTR3A SLC6A4
8 attention deficit-hyperactivity disorder 27.1 COMT HTR1A HTR1B HTR2C SLC6A3 SLC6A4
9 disease of mental health 26.9 COMT HTR1A HTR2C PDE5A SLC6A3 SLC6A4
10 impotence 10.6
11 kleptomania 10.6 HTR1A SLC6A4
12 intermittent explosive disorder 10.5 HTR1A SLC6A4
13 agoraphobia 10.5 HTR1A SLC6A4
14 alcohol-induced mental disorder 10.5 SLC6A3 SLC6A4
15 alcoholic psychosis 10.4 SLC6A3 SLC6A4
16 prostatitis 10.4
17 pathological gambling 10.4 SLC6A3 SLC6A4
18 migraine without aura 10.4 HTR1A SLC6A4
19 placental choriocarcinoma 10.3 LEP SLC6A4
20 rumination disorder 10.2 HTR1A HTR3A
21 periodic limb movement disorder 10.2 HTR1A HTR2C SLC6A4
22 amphetamine abuse 10.2 HTR1B SLC6A3
23 motion sickness 10.2 HTR1A HTR3A
24 cocaine dependence 10.2 SLC6A3 SLC6A4
25 aging 10.1
26 hyperthyroidism 10.1
27 machado-joseph disease 10.1 HTR1A SLC6A3
28 amnestic disorder 10.0 HTR1A HTR3A
29 paine syndrome 10.0
30 mucositis 10.0
31 hypogonadotropic hypogonadism 10.0
32 hypogonadism 10.0
33 vaginitis 10.0
34 infertility 10.0
35 hypogonadotropism 10.0
36 substance dependence 10.0 HTR1B SLC6A3 SLC6A4
37 functional gastric disease 10.0 HTR3A PDE5A
38 body mass index quantitative trait locus 1 9.9
39 serotonin syndrome 9.9 HTR1A HTR3A SLC6A4
40 dyspepsia 9.9 HTR1A HTR3A SLC6A4
41 generalized anxiety disorder 9.9 HTR1A HTR3A SLC6A4
42 paranoid schizophrenia 9.8 COMT SLC6A4
43 sudden infant death syndrome 9.8 HTR1A HTR3A SLC6A4
44 spondyloarthropathy 1 9.8
45 hypogonadotropic hypogonadism 7 with or without anosmia 9.8
46 prostate cancer 9.8
47 prostatic hyperplasia, benign 9.8
48 peyronie's disease 9.8
49 brain injury 9.8
50 diabetes mellitus 9.8

Graphical network of the top 20 diseases related to Premature Ejaculation:



Diseases related to Premature Ejaculation

Symptoms & Phenotypes for Premature Ejaculation

GenomeRNAi Phenotypes related to Premature Ejaculation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.28 HTR1A HTR3A SLC6A4
3 Decreased viability GR00402-S-2 9.28 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Premature Ejaculation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 SLC6A3 COMT HTR1A SLC6A4 HTR1B HTR2C
2 endocrine/exocrine gland MP:0005379 9.8 SLC6A3 COMT SLC6A4 HTR1B HTR3A LEP
3 homeostasis/metabolism MP:0005376 9.8 SLC6A3 COMT HTR1A SLC6A4 HTR2C HTR3A
4 integument MP:0010771 9.55 SLC6A3 SLC6A4 HTR2C HTR3A LEP
5 muscle MP:0005369 9.43 SLC6A3 SLC6A4 HTR1B HTR2C HTR3A LEP
6 nervous system MP:0003631 9.17 SLC6A3 COMT HTR1A SLC6A4 HTR2C HTR3A

Drugs & Therapeutics for Premature Ejaculation

Drugs for Premature Ejaculation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 77-92-9 311
3 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
4 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
5 Sildenafil Citrate Phase 4,Phase 3,Phase 2,Phase 1 171599-83-0
6 Vasodilator Agents Phase 4,Phase 2,Phase 1
7 Citrate Nutraceutical Phase 4,Phase 2,Phase 1
8
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1 137-58-6 3676
9
Clomipramine Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 303-49-1 2801
10
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
11
Norflurane Approved, Investigational Phase 2, Phase 3 811-97-2
12
Prilocaine Approved Phase 2, Phase 3,Phase 1 721-50-6 4906
13
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
14 Anesthetics Phase 3,Phase 2,Phase 1
15 Anesthetics, Local Phase 3,Phase 2,Phase 1
16 Anti-Arrhythmia Agents Phase 3,Phase 2
17 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
18 Diuretics, Potassium Sparing Phase 3,Phase 2
19 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Early Phase 1
20 Sodium Channel Blockers Phase 3,Phase 2
21 Antidepressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
22 Antidepressive Agents, Second-Generation Phase 3,Early Phase 1
23 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
24 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
25 Psychotropic Drugs Phase 3,Phase 2,Phase 1,Early Phase 1
26 Serotonin Agents Phase 3,Phase 2,Phase 1,Early Phase 1
27 Serotonin Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
28 Antidepressive Agents, Tricyclic Phase 3,Phase 2,Phase 1
29 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 3
31 EMLA Phase 2, Phase 3,Phase 1
32 Vardenafil Dihydrochloride Phase 3
33 Analgesics Phase 3
34 Analgesics, Opioid Phase 3
35 Narcotics Phase 3
36
Serotonin Investigational, Nutraceutical Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-67-9 5202
37
Silodosin Approved Phase 2 160970-54-7
38
Acetylcholine Approved Phase 2 51-84-3 187
39 Adrenergic Agents Phase 2,Phase 1
40 Adrenergic alpha-1 Receptor Antagonists Phase 2,Phase 1
41 Adrenergic alpha-Antagonists Phase 2,Phase 1
42 Adrenergic Antagonists Phase 2,Phase 1
43 Cholinergic Agents Phase 2,Early Phase 1
44 Anti-Bacterial Agents Phase 2,Phase 1
45 Anti-Infective Agents Phase 2,Phase 1
46 Diketopiperazines Phase 2,Phase 1
47 abobotulinumtoxinA Phase 2
48 Botulinum Toxins Phase 2
49 Botulinum Toxins, Type A Phase 2
50 Neuromuscular Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
2 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
3 Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation Unknown status NCT02241460 Phase 3 Placebo;Promescent Lidocaine Spray
4 Glans Penis Augmentation by Hyaluronic Acid for Treatment of Premature Ejaculation Completed NCT03459833 Phase 3 Hyaluronic Acid
5 Efficacy and Safety of Paroxetine Daily Doses of 15 mg and 20 mg in the Treatment of Premature Ejaculation Completed NCT01024491 Phase 3 paroxetine;paroxetine;placebo
6 Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation Completed NCT00556478 Phase 2, Phase 3 PSD502, contains a mixture of lidocaine and prilocaine;Placebo
7 Trial of PED-1 in Male Patients With Premature Ejaculation Completed NCT01439984 Phase 3 Clomipramine
8 The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy Completed NCT01063881 Phase 3 Dapoxetine
9 A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation Completed NCT00210613 Phase 3 Dapoxetine
10 Assessment of Efficacy and Safety of UK-390,957 in Men With Premature Ejaculation Completed NCT00143117 Phase 2, Phase 3 UK-390,957
11 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00210704 Phase 3 Dapoxetine
12 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00229073 Phase 3 dapoxetine
13 Assessment Of Efficacy and Safety UK-390,957 In Men With Premature Ejaculation Completed NCT00219635 Phase 2, Phase 3 UK-390,957
14 Assessment Of Efficacy and Safety Of UK-390,957 In Men With Premature Ejaculation Completed NCT00219583 Phase 2, Phase 3 UK-390,957
15 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00211094 Phase 3 Dapoxetine
16 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation. Completed NCT00211107 Phase 3 Dapoxetine
17 Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction Completed NCT01063855 Phase 3 Placebo;Dapoxetine;PDE5I (phosphodiesterase-5 inhibitor)
18 Assessment Of Safety Of UK-390,957 Completed NCT00219609 Phase 2, Phase 3 UK-390,957
19 An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation Completed NCT01230762 Phase 3 dapoxetine
20 Study to Evaluate Efficacy and Safety in Male Subjects With Premature Ejaculation Terminated NCT00983736 Phase 3 Tramadol Hydrochloride;Placebo
21 Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation Terminated NCT00983151 Phase 3 Tramadol Hydrochloride & Placebo
22 A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation Unknown status NCT02571101 Phase 2 CDFR0812-15/25mg;CDFR0812-15/50mg;Condencia;CDFR0812-Placebo;Condencia-Placebo
23 Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation Unknown status NCT01798667 Phase 2 DA-8031;Placebo
24 Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation Unknown status NCT02581826 Phase 2 Silodosin;Placebo
25 A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation Completed NCT00537459 Phase 2 16448
26 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE) Completed NCT02232425 Phase 2 IX-01;Placebo
27 Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation Completed NCT01203202 Phase 2 Clomipramine
28 A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation Completed NCT01021553 Phase 2 GSK557296;GSK557296;placebo
29 Exploratory Study of Pagoclone in Men With Premature Ejaculation. Completed NCT00370981 Phase 2 pagoclone
30 Safety, Tolerability, Pharmacokinetics and Efficacy of YHD1044 Completed NCT01419470 Phase 1, Phase 2 dapoxetine
31 Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery Recruiting NCT02648386 Phase 1, Phase 2
32 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE) Active, not recruiting NCT03055806 Phase 2 IX-01 400 mg;Placebo;IX-01 800 mg;IX-01 1200 mg
33 PSD502 in Subjects With Premature Ejaculation Not yet recruiting NCT03578783 Phase 2 Placebo;PSD502
34 A Safety and Efficacy Study of BOTOX® in Premature Ejaculation Terminated NCT01917006 Phase 2 OnabotulinumtoxinA;Normal Saline
35 Proof of Mechanism in ELT Completed NCT00861484 Phase 1 GSK958108;Placebo
36 A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation Completed NCT01184105 Phase 1 Intervention A;Intervention B
37 FTIH Study With GSK958108 Completed NCT00664365 Phase 1 GSK958108;Placebo
38 A Safety and Tolerability Study of Administration of PSD502 Completed NCT01183208 Phase 1 Intervention A;Intervention B;Intervention C;Intervention D;Intervention E
39 A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296. Completed NCT00549211 Phase 1 GSK557296
40 Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males Completed NCT02028598 Phase 1 Treatment 1;Treatment 2;Treatment 3
41 A Pharmacodynamic Study of Dapoxetine Concomitantly Administered in Participants Taking Terazosin Completed NCT01366664 Phase 1 Treatment sequence 2;Treatment sequence 1
42 A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects Terminated NCT00449709 Phase 1 GSK221149
43 Primary Premature Ejaculation Genetics Unknown status NCT02109302 Not Applicable
44 Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation Unknown status NCT00656552 Early Phase 1 Escitalopram
45 Male Reproductive Health of Floating Population: a Large-Scale Survey in Dongguan Unknown status NCT01901029
46 Management of Sexual Dysfunction With Bioresonance Technique Unknown status NCT02028013
47 The Impact and Benefit of Physical Activity on Premature Ejaculation Completed NCT02844998 Not Applicable dapoxetine 30 mg on demand
48 Effect of Exercise on Premature Ejaculation Completed NCT02984592
49 Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center Research Completed NCT02572037
50 Efficacy of a New Behavioral Treatment for Premature Ejaculation Using a Masturbation Aid Device: Star-Stop 3.0 Completed NCT03304808 Not Applicable

Search NIH Clinical Center for Premature Ejaculation

Cochrane evidence based reviews: premature ejaculation

Genetic Tests for Premature Ejaculation

Anatomical Context for Premature Ejaculation

MalaCards organs/tissues related to Premature Ejaculation:

41
Prostate, Skin, Testes, Heart, Brain, Liver, Kidney

Publications for Premature Ejaculation

Articles related to Premature Ejaculation:

(show top 50) (show all 661)
# Title Authors Year
1
Pharmacological interventions for premature ejaculation: a mixed-treatment comparison network meta-analysis of randomized clinical trials. ( 29921893 )
2018
2
The Efficacy and Safety of On-demand Tramadol and Paroxetine Use in Treatment of Life Long Premature Ejaculation: A Randomized Double-blind Placebo-controlled Clinical Trial. ( 29850442 )
2018
3
Re: Re: Karabakan M, Bozkurt A, Hirik E, Celebi B, Akdemir S, Guzel O, Nuhoglu B. The prevalence of premature ejaculation in young Turkish men. Andrologia 2016; 24: 1-5. ( 29336072 )
2018
4
The relationship between female sexual function index domains and premature ejaculation. ( 29497891 )
2018
5
Acquired premature ejaculation in Parkinson's disease and possible mechanisms. ( 29855551 )
2018
6
No effect of abstinence time on nerve electrophysiological test in premature ejaculation patients. ( 29600795 )
2018
7
Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation: long-term outcomes. ( 29974885 )
2018
8
Do we have put a new cornerstone for the treatment of premature ejaculation? ( 29930264 )
2018
9
Premature Ejaculation Among Italian Men: Prevalence and ClinicalA Correlates From an Observational, Non-Interventional, Cross-Sectional, Epidemiological Study (IPER). ( 29803639 )
2018
10
Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response. ( 29952430 )
2018
11
Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction. ( 29405168 )
2018
12
Effects of the dopamine D<sub>3</sub>receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model. ( 29369372 )
2018
13
The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study. ( 29633800 )
2018
14
Visceral adiposity index is associated with premature ejaculation inversely: a cross-sectional study. ( 29338524 )
2018
15
Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients. ( 29872385 )
2018
16
Efficacy and safety of daily use of tadalafil in treatment ofA patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 29527702 )
2018
17
A Randomized Double-blind Placebo-controlled Trial to Assess the Effect of Tamarind seed in Premature Ejaculation. ( 29862208 )
2018
18
Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study. ( 28736888 )
2017
19
Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 28497478 )
2017
20
The prevalence of an excessive prepuce and the effects of distal circumcision on premature ejaculation. ( 29071143 )
2017
21
Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. ( 28627033 )
2017
22
Phosphodiesterase-5 inhibitors for premature ejaculation: a systematic review and meta-analysis. ( 28702510 )
2017
23
Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism. ( 27679962 )
2017
24
A case report of over-the-counter codeine dependence as consequence of self-medication for premature ejaculation. ( 29564281 )
2017
25
Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going. ( 27704632 )
2017
26
Study of the link between dopamine transporter gene polymorphisms and response to paroxetin and escitalopram in patients with lifelong premature ejaculation. ( 28904397 )
2017
27
Phosphodiesterase Type 5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis. ( 28720356 )
2017
28
No Evidence for Long-Term Causal Associations Between Symptoms of Premature Ejaculation and Symptoms of Anxiety, Depression, and Sexual Distress in a Large, Population-Based Longitudinal Sample. ( 27982691 )
2017
29
Re: Rasch Analysis of the Premature Ejaculation Diagnostic Tool (PEDT) and the International Index of Erectile Function (IIEF) in an Iranian Sample of Prostate Cancer Patients. ( 28505932 )
2017
30
Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. ( 28730747 )
2017
31
Re: Karabakan M, Bozkurt A, Hirik E, Celebi B, Akdemir S, Guzel O, Nuhoglu B. The prevalence of premature ejaculation in young Turkish men. Andrologia 2016; 24: 1-5. ( 28795478 )
2017
32
Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation. ( 28065363 )
2017
33
Re: Validity of Premature Ejaculation Diagnostic Tool and its Association with International Index of Erectile Function-15 in Chinese Men with Evidence-Based-Defined Premature Ejaculation. ( 29370617 )
2017
34
Significance of penile hypersensitivity in premature ejaculation. ( 28874780 )
2017
35
Circumcision does not have effect on premature ejaculation: A systematic review and meta-analysis. ( 28653427 )
2017
36
Sexual Cognitions, Trait Anxiety, Sexual Anxiety, and Distress in Men With Different Subtypes of Premature Ejaculation and in Their Partners. ( 29161211 )
2017
37
Premature ejaculation: Pharmacotherapy vs group psychotherapy alone or in combination. ( 28679182 )
2017
38
Premature ejaculation is not a disease. ( 28556270 )
2017
39
Editorial Comment to Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. ( 28733993 )
2017
40
Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation. ( 29198511 )
2017
41
Re: Silodosin versus Naftopidil in the Treatment of Premature Ejaculation: AA Prospective Multicenter Trial. ( 29144913 )
2017
42
Efficacy of combined traditional Chinese medicine spray with premature ejaculation desensitization therapy for the treatment of primary premature ejaculation. ( 29085387 )
2017
43
Transcutaneous neuromuscular electrical stimulation may be beneficial in the treatment of premature ejaculation. ( 29150283 )
2017
44
Premature Ejaculation: A Redundant Entity in the Era of Somatic Symptom Disorder? ( 28615783 )
2017
45
Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses. ( 28913588 )
2017
46
Pharmacological/dynamic rehabilitative behavioural therapy for premature ejaculation: Results of a pilot study. ( 28679189 )
2017
47
Premature ejaculation: challenging new and the old concepts. ( 29259775 )
2017
48
Where do we come from and where are we going in the treatment of premature ejaculation? ( 28919100 )
2017
49
Tolerability and adequate therapeutic dosage of oral clomipramine for the treatment of premature ejaculation: A randomized, double-blind, placebo-controlled, fixed-dose, parallel-grouped clinical study. ( 29203842 )
2017
50
Possible role of serum testosterone, gonadotropins and prolactin in patients with premature ejaculation. ( 28439908 )
2017

Variations for Premature Ejaculation

Expression for Premature Ejaculation

Search GEO for disease gene expression data for Premature Ejaculation.

Pathways for Premature Ejaculation

GO Terms for Premature Ejaculation

Cellular components related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.33 COMT HTR3A SLC6A3
2 dendrite GO:0030425 9.26 COMT HTR1A HTR1B HTR2C
3 integral component of plasma membrane GO:0005887 9.1 HTR1A HTR1B HTR2C HTR3A SLC6A3 SLC6A4

Biological processes related to Premature Ejaculation according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.76 HTR1A HTR1B HTR2C HTR3A
2 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.61 HTR1A HTR1B HTR2C
3 neurotransmitter transport GO:0006836 9.59 SLC6A3 SLC6A4
4 feeding behavior GO:0007631 9.58 HTR1B HTR2C
5 behavioral fear response GO:0001662 9.58 HTR1A HTR2C
6 G-protein coupled serotonin receptor signaling pathway GO:0098664 9.57 HTR1A HTR1B
7 response to ethanol GO:0045471 9.56 HTR1B HTR3A LEP SLC6A3
8 neurotransmitter biosynthetic process GO:0042136 9.55 SLC6A3 SLC6A4
9 response to drug GO:0042493 9.55 COMT HTR1B HTR2C SLC6A3 SLC6A4
10 regulation of behavior GO:0050795 9.54 HTR1A HTR1B
11 regulation of dopamine metabolic process GO:0042053 9.52 HTR1A SLC6A3
12 monoamine transport GO:0015844 9.51 SLC6A3 SLC6A4
13 response to cocaine GO:0042220 9.5 HTR1B HTR3A SLC6A3
14 dopamine catabolic process GO:0042420 9.49 COMT SLC6A3
15 dopamine uptake involved in synaptic transmission GO:0051583 9.48 SLC6A3 SLC6A4
16 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.4 HTR1A HTR1B
17 serotonin receptor signaling pathway GO:0007210 9.37 HTR1A HTR2C
18 vasoconstriction GO:0042310 9.13 HTR1A HTR1B SLC6A4
19 behavior GO:0007610 8.8 HTR1A HTR1B HTR2C
20 signal transduction GO:0007165 10.03 HTR1A HTR1B HTR2C HTR3A LEP PDE5A

Molecular functions related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.5 HTR1B HTR2C SLC6A3
2 neurotransmitter:sodium symporter activity GO:0005328 9.4 SLC6A3 SLC6A4
3 monoamine transmembrane transporter activity GO:0008504 9.37 SLC6A3 SLC6A4
4 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR1B HTR2C
5 dopamine:sodium symporter activity GO:0005330 9.26 SLC6A3 SLC6A4
6 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR1B HTR2C
7 serotonin binding GO:0051378 8.92 HTR1A HTR1B HTR2C HTR3A

Sources for Premature Ejaculation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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