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MCID: PRM020
MIFTS: 50

Premenstrual Tension

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Premenstrual Tension

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MalaCards integrated aliases for Premenstrual Tension:

Name: Premenstrual Tension 12 15 73
Premenstrual Syndrome 44 63 73

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:727
ICD10 33 N94.3
ICD9CM 35 625.4
MeSH 44 D011293
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Summaries for Premenstrual Tension

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PubMed Health : 63 About premenstrual syndrome: In the days leading up to their period, many women experience abdominal pain or a headache, are sad and irritable or feel bloated and generally uncomfortable. The medical term for this is “premenstrual syndrome” (PMS), also known as “premenstrual tension” (PMT). PMS symptoms are usually not very severe, and most women cope well with them. But in some women it is so bad that they are unable to go about their everyday lives during that time. Various treatments and measures can help to relieve PMS.

MalaCards based summary : Premenstrual Tension, also known as premenstrual syndrome, is related to anovulation and endogenous depression, and has symptoms including pelvic pain, unspecified symptom associated with female genital organs and mittelschmerz. An important gene associated with Premenstrual Tension is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Nongenotropic Androgen signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The drugs Drospirenone and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and brain, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia : 76 Premenstrual syndrome (PMS) refers to physical and emotional symptoms that occur in the one to two weeks... more...

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Related Diseases for Premenstrual Tension

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Diseases related to Premenstrual Tension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 anovulation 30.3 GNRH1 PRL SHBG
2 endogenous depression 29.8 CRH GNRH1 OXT POMC
3 acute adrenal insufficiency 10.9 POMC REN
4 hypoaldosteronism 10.9 POMC REN
5 perinephritis 10.8 MGAM REN
6 myofascial pain syndrome 10.8 CAMP POMC
7 central nervous system germinoma 10.7 AVP POMC
8 tuberculous epididymitis 10.7 AVP POMC
9 retroperitoneal leiomyosarcoma 10.7 PGR REN
10 endometriosis of uterus 10.7 GNRH1 PRL
11 mineral metabolism disease 10.7 MGAM POMC REN
12 central nervous system germ cell tumor 10.7 AVP POMC
13 adenohypophysitis 10.7 POMC PRL
14 hypogonadotropism 10.7 GNRH1 PRL
15 acth deficiency, isolated 10.6 CRH POMC
16 intracystic papillary adenoma 10.6 PGR PRL
17 adrenal cortical hypofunction 10.6 CRH POMC REN
18 benign essential hypertension 10.6 AVP MGAM REN
19 pituitary infarct 10.6 GNRH1 POMC PRL
20 chiasmal syndrome 10.6 GNRH1 POMC PRL
21 pituitary apoplexy 10.6 GNRH1 POMC PRL
22 inappropriate adh syndrome 10.5 AVP POMC REN
23 empty sella syndrome 10.5 GNRH1 POMC PRL
24 adrenal adenoma 10.5 CRH POMC REN
25 adrenal carcinoma 10.5 CRH POMC REN
26 secondary hypertrophic osteoarthropathy 10.5 AVP POMC
27 freemartinism 10.5 GNRH1 OXT
28 hypoadrenalism 10.5 CRH POMC SHBG
29 sella turcica neoplasm 10.4 PGR POMC PRL
30 tuberculum sellae meningioma 10.4 PGR POMC PRL
31 cell type benign neoplasm 10.4 POMC PRL REN
32 estrogen excess 10.4 PGR SHBG
33 pituitary carcinoma 10.4 CRH POMC PRL
34 nelson syndrome 10.4 CRH POMC PRL
35 sheehan syndrome 10.4 CRH POMC PRL
36 acth-secreting pituitary adenoma 10.4 CRH POMC PRL
37 postmenopausal atrophic vaginitis 10.4 OXT SHBG
38 pain agnosia 10.4 LIPN OXT POMC
39 agnosia 10.4 LIPN OXT POMC
40 adrenal gland hyperfunction 10.3 CRH POMC PRL
41 varicocele 10.3 GNRH1 PRL SHBG
42 conn's syndrome 10.3 CRH POMC REN
43 central nervous system organ benign neoplasm 10.3 AVP POMC PRL
44 melancholia 10.3 CRH HP PRL
45 pituitary hormone deficiency, combined, 2 10.3 AVP POMC PRL
46 premature ovarian failure 1 10.3 GNRH1 PRL SHBG
47 ovarian disease 10.3 GNRH1 PRL SHBG
48 myoma 10.3 GNRH1 OXT PGR
49 gonadal disease 10.3 CRH GNRH1 POMC SHBG
50 neurotic disorder 10.3 CAMP LIPN

Graphical network of the top 20 diseases related to Premenstrual Tension:



Diseases related to Premenstrual Tension
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Symptoms & Phenotypes for Premenstrual Tension

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UMLS symptoms related to Premenstrual Tension:


pelvic pain, unspecified symptom associated with female genital organs, mittelschmerz, pain and other symptoms associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Premenstrual Tension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 AVP CRH FLCN GNRH1 HP LIPN
2 endocrine/exocrine gland MP:0005379 9.97 POMC PRL SP6 CRH GNRH1 LRP5
3 immune system MP:0005387 9.96 CAMP CRH FLCN GNRH1 HP LRP5
4 integument MP:0010771 9.76 GNRH1 OXT PGR PNN POMC PRL
5 neoplasm MP:0002006 9.43 FLCN GNRH1 HP PGR POMC PRL
6 renal/urinary system MP:0005367 9.23 AVP CRH FLCN GNRH1 HP OXT
Sources

Drugs & Therapeutics for Premenstrual Tension

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PubMedHealth treatment related to Premenstrual Tension: 63

There isn’t much good research on what can help reduce PMS. So it isn’t clear how effective many of the PMS treatments are.Girls and women with PMS often try out different things to reduce their symptoms. For instance, some women with mild PMS try out relaxation techniques, acupuncture, getting more exercise, drinking less alcohol and coffee, or eating less salt. Others use herbal products and dietary supplements such as chaste tree extracts (Vitex agnus castus), St. John’s wort, calcium or pyridoxine vitamin B6).More severe PMS can be treated with a number of medications. But many of these medications haven’t been approved for the treatment of PMS, and they can have side effects:Hormone medications like the birth control pill or hormone patches affect women’s hormone levels and lead to an improvement in PMS or PMDD.Antidepressants: SSRIs (selective serotonin reuptake inhibitors) can help reduce severe psychological problems caused by PMS or PMDD.Painkillers can effectively relieve severe period pain and are usually well tolerated. There is very little research on whether they also help in PMS, though.Women who have problems with PMS-related water retention can take diuretics (water pills).If PMS causes psychological problems, cognitive behavioral therapy (CBT) is an option. But it isn’t clear whether it helps in PMS.

Drugs for Premenstrual Tension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Drospirenone Approved Phase 4,Phase 3,Phase 2,Not Applicable 67392-87-4 68873
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 979-32-8
3
Progesterone Approved, Vet_approved Phase 4,Phase 2 57-83-0 5994
4
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 54910-89-3 3386
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757
6
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Not Applicable 57-63-6 5991
7
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
8
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
9
Sertraline Approved Phase 4,Phase 1,Phase 2 79617-96-2 68617
10
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Frovatriptan Approved, Investigational Phase 4 158747-02-5 77992
13
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
14
Desogestrel Approved Phase 4 54024-22-5 40973
15
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
16
Flutamide Approved, Investigational Phase 4 13311-84-7 3397
17
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
18
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
19
Paroxetine Approved, Investigational Phase 4,Phase 3 61869-08-7 43815
20
Sumatriptan Approved, Investigational Phase 4,Phase 3 103628-46-2 5358
21
Eletriptan Approved, Investigational Phase 4 143322-58-1 77993
22
Dinoprostone Approved Phase 4 363-24-6 5280360
23
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
24
Nicotine Approved Phase 4 54-11-5 942 89594
25
Citalopram Approved Phase 4 59729-33-8 2771
26 Tezosentan Investigational Phase 4 180384-57-0
27
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
28 Progestins Phase 4,Phase 2
29 Analgesics Phase 4,Phase 3
30 diuretics Phase 4,Phase 3,Phase 2,Not Applicable
31 Central Nervous System Depressants Phase 4,Phase 1
32 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
33 Mineralocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
34 Serotonin Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
35 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
36 Natriuretic Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Contraceptive Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Contraceptives, Oral Phase 4,Phase 3,Phase 2,Not Applicable
39 Contraceptives, Oral, Combined Phase 4,Phase 3,Not Applicable
40 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Analgesics, Non-Narcotic Phase 4,Phase 3
42 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
43 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Not Applicable
44 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Not Applicable
45 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Tranquilizing Agents Phase 4,Phase 1
47 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Not Applicable
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Drospirenone and ethinyl estradiol combination Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 117)
# Name Status NCT ID Phase Drugs
1 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4 Estradiol or Placebo;Estradiol or Placebo
2 Athena Pelvic Muscle Trainer - DUETS Trial Completed NCT01073878 Phase 4
3 Effectiveness of Flutamide in Treating Women With Premenstrual Dysphoric Disorder Completed NCT00611923 Phase 4 Flutamide;Placebo
4 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
5 Atomoxetine, Placebo and Parent Management Training in Autism Completed NCT00844753 Phase 4 atomoxetine;Placebo
6 Ultrasound Plus Nerve Stimulator Versus Nerve Stimulator Guided Lumbar Plexus Block Completed NCT02020096 Phase 4
7 Treatment of Severe Childhood Aggression (The TOSCA Study) Completed NCT00796302 Phase 4 Methylphenidate HCl;Risperidone;Placebo
8 Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder Completed NCT00536198 Phase 4 Sertraline;Placebo
9 Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS) Completed NCT00318773 Phase 4 sertraline
10 Premenstrual Symptoms Treatment Comparing Between Oral Contraceptives Containing Desogestrel and Drospirenone Completed NCT01482338 Phase 4 EE 20 microgram with desogestrel 150 mg;EE 20 microgram with drospirenone 3 mg
11 A Placebo-Controlled Study to Investigate the Onset of Action of Paroxetine in Premenstrual Dysphoria Completed NCT00516113 Phase 4 paroxetine
12 The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder Completed NCT00678574 Phase 4 fluoxetine
13 An Investigation of the Safety and Utility of Treximet in the Treatment of Menstrual Migraine Completed NCT01578941 Phase 4
14 CGRP, Estrogen, Cortisol, VIP, α-Amylase, PGE2, PGI2 and ß-Endorphin Levels in Menstrual Migraine Before and After Treximet Completed NCT01329562 Phase 4 Treximet;Placebo
15 Prospective Survey of Menstrual Migraine & Prevention With Eletriptan Completed NCT00259649 Phase 4 eletriptan
16 Chances for Success of CavatermTM Surgery as a Function of Uterus Probe Length Completed NCT01436903 Phase 4
17 Effectiveness And Safety Of Frovatriptan For The Management (Acute Treatment) Of Menstrual Migraine Completed NCT00904098 Phase 4 Frovatriptan;Usual Care
18 Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD) Completed NCT00927095 Phase 4 Continuous OC (EE/DROS);Intermittent OC (EE/DROS);placebo
19 Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis Recruiting NCT02959801 Phase 4
20 Progesterone and Brain Imaging Study Recruiting NCT01954966 Phase 4 Progesterone;Placebo
21 Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients Not yet recruiting NCT03452891 Phase 4 Simvastatin-Methylcellulose
22 Escitalopram for Premenstrual Syndrome (PMS) in Teens: A Pilot Study Terminated NCT00523705 Phase 4 escitalopram
23 Homeopathic Treatment of Premenstrual Syndrome Unknown status NCT02402049 Phase 3 Natrum muriaticum 30C;Lachesis 30C;Sepia 30C;Nux vomica 30C;Pulsatilla 30C;Folliculinum 30C;Placebo Natrum muriaticum;Placebo Lachesis;Placebo Sepia;Placebo Nux vomica;Placebo pulsatilla;Placebo Folliculinum
24 Does Adding Oral Contraceptives to Fluoxetine Improve the Management of Premenstrual Syndrome? Unknown status NCT02562053 Phase 3 Fluoxetine;Combined oral contraceptives;Placebo 1;Placebo 2
25 GAMALINE®+HIPERICIN® for PMS Treatment and Vasomotor Symptoms Unknown status NCT01365676 Phase 3 GAMALINE® + HIPERICIN®;GAMALINE®
26 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
27 Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder Unknown status NCT01217775 Phase 3 PH80;Placebo intranasal spray
28 Operations and Pelvic Muscle Training in the Management of Apical Support Loss: The OPTIMAL Trial Completed NCT00597935 Phase 3
29 Luteal Phase Administration of Paroxetine for the Treatment of PMDD Completed NCT00620581 Phase 3 Paroxetine
30 Comparison Between Oral Contraceptive Pills and Calcium Supplements in Treatment of Premenstrual Syndrome Completed NCT02089620 Phase 3 Yasmin;Placebo 1;Placebo 2
31 Dose-dependent Effects of VAC BNO 1095 on Cyclic Mastodynia and Premenstrual Syndrome Completed NCT01309113 Phase 3 VAC BNO 1095 film coated tablets
32 Study Evaluating Combination of Levonorgestrel (LNG) and Ethinyl Estradiol (EE) in Premenstrual Dysphoric Disorder Completed NCT00128934 Phase 3 levonorgestrel/ethinyl estradiol
33 Study Evaluating Levonorgestrel/Ethinyl Estradiol (LNG/EE) in PMS Completed NCT00161681 Phase 3 Levonorgestrel/Ethinyl Estradiol
34 Study Evaluating Combination of Levonorgestrel and Ethinyl Estradiol in Pre-Menstrual Dysphoric Disorder Completed NCT00195559 Phase 3 Levonorgestrel/Ethinyl Estradiol
35 Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study Completed NCT02508103 Phase 2, Phase 3 Oxytocin;Placebo
36 The Effect of Toremifene Treatment to the Magnetic Resonance Imaging (MRI) Findings in Premenstrual Mastalgia Completed NCT00534846 Phase 3 toremifene;placebo
37 Treximet (Sumatriptan/Naproxen Sodium), Formerly Known as TREXIMA, for Menstrual Migraine in Women With Dysmenorrhea Completed NCT00329459 Phase 3 sumatriptan succinate/naproxen sodium;placebo
38 Menstrual Migraine Treatment With TREXIMET (Formerly Known as TREXIMA) Completed NCT00329355 Phase 3 sumatriptan succinate/naproxen sodium
39 Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder Completed NCT01912391 Phase 3 Selegiline;Placebo (for Selegiline)
40 Diindolylmethane in Treating Patients With Abnormal Cervical Cells Completed NCT00462813 Phase 3 oral microencapsulated diindolylmethane
41 YAZ Premenstrual Dysphoric Disorder (PMDD) in China Completed NCT00824187 Phase 3 EE20/DRSP(YAZ, BAY86-5300);Placebo
42 The Impact of Serelys PMS on Symptoms of PMS Recruiting NCT03298607 Phase 3
43 Dienogest Versus Luteal Phase Fluoxetine in the Management of Premenstrual Syndrome Recruiting NCT02427334 Phase 3 Dienogest;Fluoxetine;Placebo
44 Combined Oral Contraceptives and Fluoxetine Versus Combined Oral Contraceptives in Severe Premenstrual Syndrome Recruiting NCT02488538 Phase 3 Combined oral contraceptives;Fluoxetine;Combined oral contraceptives placebo;Fluoxetine placebo
45 Efficacy and Safety of 20 mg (2 Tablets of 10mg)VAC BNO 1095 FCT on Cyclic Mastodynia and PMS Terminated NCT01870687 Phase 3 20mg VAC BNO 1095 FCT;Placebo
46 Foster Teens' Risk During Transition Unknown status NCT02037750 Phase 2
47 Evaluation of Safety/Efficacy of Diagnostic Skin Test Panel and Desensitization Hormone Kit for Treatment of Premenstrual Syndrome (PMS) Unknown status NCT00873262 Phase 2 Skin test panel and desensitization kit;Skin test panel and solvent
48 Evaluation of Efficacy/Safety of EVE-PMS Skin Test Panel Unknown status NCT00866437 Phase 2 Skin test panel;Skin test panel
49 Antidepressant Treatment for Premenstrual Syndrome and Premenstrual Dysphoric Disorder Completed NCT00048854 Phase 1, Phase 2 Sertraline
50 a Clinical Trial to Evaluate the Efficacy and Safety of Agnucaston Tablets in the Treatment of Premenstrual Syndrome (PMS) Completed NCT00672607 Phase 2 extracts of Vitex agnus castus tablets;Placebo

Search NIH Clinical Center for Premenstrual Tension

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: premenstrual syndrome

Sources

Genetic Tests for Premenstrual Tension

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Anatomical Context for Premenstrual Tension

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MalaCards organs/tissues related to Premenstrual Tension:

41
Testes, Skin, Brain, Bone, Cortex, Uterus, Lung
Sources

Publications for Premenstrual Tension

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Articles related to Premenstrual Tension:

(show top 50) (show all 240)
# Title Authors Year
1
Relationship between Anxiety and Interleukin 10 in Female Soccer Players with and Without Premenstrual Syndrome (PMS). ( 28847026 )
2017
2
Association of premenstrual syndrome and premenstrual dysphoric disorder with bulimia nervosa and binge-eating disorder in a nationally representative epidemiological sample. ( 27206163 )
2016
3
Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT<sub>3A</sub>R and 5-HT<sub>3B</sub>R Expression in the Rat Brain. ( 27725889 )
2016
4
Acupuncture for knee osteoarthritis, chasteberry for premenstrual syndrome, probiotics for irritable bowel syndrome, yoga for hypertension, and trigger point dry needling for plantar fasciitis. ( 25682385 )
2015
5
Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome. ( 25416214 )
2014
6
Premenstrual dysphoric disorder and severe premenstrual syndrome in adolescents. ( 23529867 )
2013
7
Blood glucose levels, insulin concentrations, and insulin resistance in healthy women and women with premenstrual syndrome: a comparative study. ( 23875163 )
2013
8
Premenstrual syndrome, body fat and bitter taste receptor gene TAS2R38 among adult Kullu females of Himachal Pradesh, India. ( 23980393 )
2013
9
Premenstrual syndrome and dysphoric disorder as risk factors for postpartum depression. ( 23157487 )
2013
10
Bipolar disorder and Premenstrual Syndrome or Premenstrual Dysphoric Disorder comorbidity: a systematic review. ( 23429819 )
2012
11
Brain-derived neurotrophic factor plasma variation during the different phases of the menstrual cycle in women with premenstrual syndrome. ( 20933336 )
2011
12
The premenstrual tension syndrome rating scales: an updated version. ( 21802738 )
2011
13
Perimenstrual headache: migraine without aura or premenstrual syndrome symptom? ( 21417101 )
2010
14
The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. ( 20155996 )
2010
15
Characterization of headaches in the premenstrual tension syndrome. ( 19330208 )
2009
16
Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. ( 17883902 )
2007
17
Malon dialdehyde, nitrite and adrenomedullin levels in patients with premenstrual syndrome. ( 17063355 )
2007
18
Role of bromocriptine and pyridoxine in premenstrual tension syndrome. ( 18476391 )
2007
19
Premenstrual syndrome. ( 19454075 )
2007
20
Cerazette for premenstrual tension. ( 16105314 )
2005
21
A psychoanalytical approach to premenstrual tension syndrome. ( 15194524 )
2004
22
Is sleep disorder treatment appropriate for premenstrual syndrome? ( 12580851 )
2003
23
The role of hormones and hormonal treatments in premenstrual syndrome. ( 12665391 )
2003
24
The etiology, biology, and evolving pathology of premenstrual syndromes. ( 12892990 )
2003
25
Serum leptin levels in patients with premenstrual syndrome treated with GnRH analogues alone and in association with tibolone. ( 14974912 )
2003
26
Historical studies of premenstrual tension up to 30 years ago: implications for future research. ( 12441020 )
2002
27
Plasma leptin concentrations are increased in women with premenstrual syndrome. ( 11056127 )
2000
28
Cyclical mastalgia: premenstrual syndrome or recurrent pain disorder? ( 10656154 )
1999
29
Women's perceptions of phenomena they label premenstrual tension: normal experiences reflecting ordinary behaviour. ( 10520105 )
1999
30
The treatment of severe premenstrual syndrome with goserelin with and without 'add-back' estrogen therapy: a placebo-controlled study. ( 10368798 )
1999
31
Prevalence of mood and anxiety disorders in women who seek treatment for premenstrual syndrome. ( 10595331 )
1999
32
Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome. ( 9848298 )
1998
33
Relationship between premenstrual tension syndrome and anxiety in Chinese adolescents. ( 9502014 )
1998
34
Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxine. ( 23195474 )
1997
35
Effect of progesterone therapy on arginine vasopressin and atrial natriuretic factor in premenstrual syndrome. ( 9258576 )
1997
36
Office gynecology for the primary care physician, part II: pelvic pain, vulvar disease, disorders of menstruation, premenstrual syndrome, and breast disease. ( 8614176 )
1996
37
Decreased central opioid activity in premenstrual syndrome: luteinizing hormone response to naloxone. ( 8796815 )
1996
38
Peripheral measures of arginine vasopressin, atrial natriuretic peptide and adrenocorticotropic hormone in premenstrual syndrome. ( 8817732 )
1996
39
Premenstrual tension among hysterectomized women. ( 8528381 )
1995
40
Ovarian suppression with the gonadotrophin-releasing hormone agonist goserelin (Zoladex) in management of the premenstrual tension syndrome. ( 7962376 )
1994
41
Changes of opioid modulation of the hypothalamo-pituitary-adrenal axis in patients with severe premenstrual syndrome. ( 7809341 )
1994
42
Nefazodone in the treatment of premenstrual syndrome: a preliminary study. ( 8027414 )
1994
43
Plasma copper, zinc and magnesium levels in patients with premenstrual tension syndrome. ( 8042455 )
1994
44
The effects of premenstrual syndrome (PMS) on the female singer. ( 8293066 )
1993
45
Increased imidazoline and alpha 2 adrenergic binding in platelets of women with dysphoric premenstrual syndromes. ( 7904832 )
1993
46
Premenstrual tension among nurses in Nairobi, Kenya. ( 8306911 )
1993
47
Brainstem auditory evoked responses (BAERs) during the menstrual cycle in women with and without premenstrual syndrome. ( 1457623 )
1992
48
Premenstrual tension syndrome with periodic bulimia nervosa: report of a case and review of the literature. ( 1360302 )
1992
49
Premenstrual tension as mitigation in a criminal case. ( 1431801 )
1992
50
Spontaneous anovulation causing disappearance of cyclical symptoms in women with the premenstrual syndrome. ( 1897330 )
1991
Sources

Variations for Premenstrual Tension

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Expression for Premenstrual Tension

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Search GEO for disease gene expression data for Premenstrual Tension.
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Pathways for Premenstrual Tension

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Pathways related to Premenstrual Tension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Nongenotropic Androgen signaling 1
10.21 GNRH1 SHBG
2
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
9.47 CRH POMC
Sources

GO Terms for Premenstrual Tension

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Cellular components related to Premenstrual Tension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 AVP CAMP CRH GNRH1 HP OXT
2 extracellular region GO:0005576 9.4 AVP CAMP CRH GNRH1 HP LIPN
3 secretory granule GO:0030141 9.33 AVP OXT POMC

Biological processes related to Premenstrual Tension according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.85 AVP GNRH1 OXT POMC PRL
2 cell-cell signaling GO:0007267 9.84 AVP GNRH1 PGR POMC
3 response to organic cyclic compound GO:0014070 9.72 AVP GNRH1 OXT
4 response to ethanol GO:0045471 9.7 AVP CRH GNRH1
5 regulation of blood pressure GO:0008217 9.65 LRP5 POMC REN
6 response to immobilization stress GO:0035902 9.56 CRH REN
7 response to peptide hormone GO:0043434 9.54 GNRH1 LRP5 OXT
8 grooming behavior GO:0007625 9.51 AVP OXT
9 maternal behavior GO:0042711 9.49 AVP OXT
10 response to prostaglandin E GO:0034695 9.43 GNRH1 OXT
11 positive regulation of cell proliferation GO:0008284 9.43 AVP CAMP CRH LRP5 PRL SP6
12 drinking behavior GO:0042756 9.4 OXT REN
13 hyperosmotic salinity response GO:0042538 9.32 AVP OXT
14 response to ether GO:0045472 9.26 CRH OXT
15 maternal aggressive behavior GO:0002125 9.16 AVP OXT
16 female pregnancy GO:0007565 8.92 CRH GNRH1 OXT PRL

Molecular functions related to Premenstrual Tension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.26 AVP CRH OXT POMC
2 neurohypophyseal hormone activity GO:0005185 9.16 AVP OXT
3 hormone activity GO:0005179 9.1 AVP CRH GNRH1 OXT POMC PRL
Sources

Sources for Premenstrual Tension

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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