Premenstrual Tension disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRM020 MIFTS: 53	Premenstrual Tension Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Premenstrual Tension

MalaCards integrated aliases for Premenstrual Tension:

Name: Premenstrual Tension ¹² ¹⁵ ⁷⁴

Premenstrual Syndrome ⁴⁵ ⁷⁴ ⁶⁴

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the genitourinary system

Noninflammatory disorders of female genital tract

Pain and other conditions associated with female genital organs and menstrual cycle

Premenstrual tension syndrome

External Ids:

Disease Ontology ¹² DOID:727

ICD9CM ³⁶ 625.4

MeSH ⁴⁵ D011293

SNOMED-CT ⁶⁹ 82639001

ICD10 ³⁴ N94.3

UMLS ⁷⁴ C0033046 C0376356

Sources

Summaries for Premenstrual Tension

PubMed Health : ⁶⁴ About premenstrual syndrome: In the days leading up to their period, many women experience abdominal pain or a headache, are sad and irritable or feel bloated and generally uncomfortable. The medical term for this is “premenstrual syndrome” (PMS), also known as “premenstrual tension” (PMT). PMS symptoms are usually not very severe, and most women cope well with them. But in some women it is so bad that they are unable to go about their everyday lives during that time. Various treatments and measures can help to relieve PMS.

MalaCards based summary : Premenstrual Tension, also known as premenstrual syndrome, is related to anovulation and postpartum depression, and has symptoms including pelvic pain, pain and other symptoms associated with female genital organs and mittelschmerz. An important gene associated with Premenstrual Tension is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Nongenotropic Androgen signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : ⁷⁷ Premenstrual syndrome (PMS) refers to physical and emotional symptoms that occur in the one to two weeks... more...

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Related Diseases for Premenstrual Tension

Diseases related to Premenstrual Tension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)

#	Related Disease	Score	Top Affiliating Genes
1	anovulation	30.2	GNRH1 PRL SHBG
2	postpartum depression	30.2	CRH OXT PRL
3	disease of mental health	30.0	CRH OXT POMC
4	sexual disorder	30.0	OXT PRL SHBG
5	breast disease	29.7	PGR POMC PRL SHBG
6	pre-eclampsia	29.7	CRH OXT REN SERPINE1
7	amenorrhea	29.6	CRH GNRH1 POMC PRL SHBG
8	anorexia nervosa	29.6	CRH OXT POMC PRL
9	acute adrenal insufficiency	10.4	POMC REN
10	hypoaldosteronism	10.4	POMC REN
11	perinephritis	10.4	MGAM REN
12	allergic encephalomyelitis	10.4	CRH POMC
13	myofascial pain syndrome	10.4	CAMP POMC
14	central nervous system germinoma	10.4	AVP POMC
15	gangliocytoma	10.4	CRH POMC
16	tuberculous epididymitis	10.4	AVP POMC
17	mineral metabolism disease	10.3	MGAM POMC REN
18	malignant hypertensive renal disease	10.3	REN SERPINE1
19	malignant renovascular hypertension	10.3	REN SERPINE1
20	adenohypophysitis	10.3	POMC PRL
21	pneumothorax	10.3	FLCN GNRH1 PGR
22	central nervous system germ cell tumor	10.3	AVP POMC
23	hypogonadotropism	10.3	GNRH1 PRL
24	intracystic papillary adenoma	10.3	PGR PRL
25	adrenal cortical hypofunction	10.3	CRH POMC REN
26	lung oat cell carcinoma	10.3	AVP POMC
27	bronchus cancer	10.3	AVP POMC
28	benign essential hypertension	10.3	AVP MGAM REN
29	pituitary infarct	10.3	GNRH1 POMC PRL
30	retroperitoneal leiomyosarcoma	10.3	PGR REN
31	adrenal gland disease	10.3	CRH POMC REN
32	chiasmal syndrome	10.3	GNRH1 POMC PRL
33	pituitary apoplexy	10.3	GNRH1 POMC PRL
34	suprasellar meningioma	10.3	PGR POMC
35	malignant secondary hypertension	10.3	REN SERPINE1
36	empty sella syndrome	10.3	GNRH1 POMC PRL
37	inappropriate adh syndrome	10.3	AVP POMC REN
38	adrenal adenoma	10.3	CRH POMC REN
39	tsh producing pituitary tumor	10.3	GNRH1 POMC PRL
40	space motion sickness	10.3	AVP MGAM REN
41	adrenal carcinoma	10.3	CRH POMC REN
42	acth deficiency, isolated	10.3	CRH POMC
43	adrenal rest tumor	10.3	GNRH1 POMC PRL
44	aortic valve disease 1	10.3	LRP5 POMC REN
45	hypoadrenalism	10.3	CRH POMC SHBG
46	tuberculous empyema	10.3	POMC SERPINE1
47	sella turcica neoplasm	10.2	PGR POMC PRL
48	tuberculum sellae meningioma	10.2	PGR POMC PRL
49	endocrine organ benign neoplasm	10.2	POMC PRL REN
50	pituitary carcinoma	10.2	CRH POMC PRL

Graphical network of the top 20 diseases related to Premenstrual Tension:

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Symptoms & Phenotypes for Premenstrual Tension

UMLS symptoms related to Premenstrual Tension:

pelvic pain, pain and other symptoms associated with female genital organs, mittelschmerz, unspecified symptom associated with female genital organs, other specified symptoms associated with female genital organs, female genital pain and other symptoms

MGI Mouse Phenotypes related to Premenstrual Tension:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.28	AVP CRH FLCN GNRH1 HP LIPN
2	hematopoietic system	MP:0005397	10.13	CAMP CRH FLCN GNRH1 HP LRP5
3	cardiovascular system	MP:0005385	10.11	FLCN HP LRP5 OXT PGR PNN
4	immune system	MP:0005387	10.11	CAMP CRH FLCN GNRH1 HP LRP5
5	integument	MP:0010771	9.97	CRH GNRH1 OXT PGR PNN POMC
6	mortality/aging	MP:0010768	9.93	AVP CAMP FLCN HP LRP5 OXT
7	liver/biliary system	MP:0005370	9.8	CRH GNRH1 HP LRP5 POMC PRL
8	neoplasm	MP:0002006	9.5	FLCN GNRH1 HP PGR POMC PRL
9	renal/urinary system	MP:0005367	9.28	AVP CRH FLCN GNRH1 HP OXT

Sources

Drugs & Therapeutics for Premenstrual Tension

PubMedHealth treatment related to Premenstrual Tension: ⁶⁴

There isn’t much good research on what can help reduce PMS. So it isn’t clear how effective many of the PMS treatments are.Girls and women with PMS often try out different things to reduce their symptoms. For instance, some women with mild PMS try out relaxation techniques, acupuncture, getting more exercise, drinking less alcohol and coffee, or eating less salt. Others use herbal products and dietary supplements such as chaste tree extracts (Vitex agnus castus), St. John’s wort, calcium or pyridoxine vitamin B6).More severe PMS can be treated with a number of medications. But many of these medications haven’t been approved for the treatment of PMS, and they can have side effects:Hormone medications like the birth control pill or hormone patches affect women’s hormone levels and lead to an improvement in PMS or PMDD.Antidepressants: SSRIs (selective serotonin reuptake inhibitors) can help reduce severe psychological problems caused by PMS or PMDD.Painkillers can effectively relieve severe period pain and are usually well tolerated. There is very little research on whether they also help in PMS, though.Women who have problems with PMS-related water retention can take diuretics (water pills).If PMS causes psychological problems, cognitive behavioral therapy (CBT) is an option. But it isn’t clear whether it helps in PMS.

Drugs for Premenstrual Tension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 199)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Estradiol

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

50-28-2

5757

Polyestradiol phosphate

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

28014-46-2

Ethinyl Estradiol

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

57-63-6

5991

Drospirenone

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

67392-87-4

68873

Fluoxetine

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

54910-89-3

3386

Progesterone

Approved, Vet_approved

Phase 4,Phase 2

57-83-0

5994

Flutamide

Approved, Investigational

Phase 4

13311-84-7

3397

Guanfacine

Approved, Investigational

Phase 4

29110-47-2

3519

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Methylphenidate

Approved, Investigational

Phase 4

113-45-1

4158

Risperidone

Approved, Investigational

Phase 4

106266-06-2

5073

Sertraline

Approved

Phase 4,Phase 1,Phase 2

79617-96-2

68617

Desogestrel

Approved

Phase 4

54024-22-5

40973

Paroxetine

Approved, Investigational

Phase 4,Phase 3

61869-08-7

43815

Leuprolide

Approved, Investigational

Phase 4

53714-56-0

657181 3911

Salmon Calcitonin

Approved, Investigational

Phase 4

47931-85-1

16129616

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Sumatriptan

Approved, Investigational

Phase 4,Phase 3

103628-46-2

5358

Naproxen

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

22204-53-1

156391 1302

Dinoprostone

Approved

Phase 4

363-24-6

5280360

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Eletriptan

Approved, Investigational

Phase 4

143322-58-1

77993

Frovatriptan

Approved, Investigational

Phase 4

158747-02-5

77992

Simvastatin

Approved

Phase 4

79902-63-9

54454

Nicotine

Approved

Phase 4

54-11-5

942 89594

Citalopram

Approved

Phase 4

59729-33-8

2771

Tezosentan

Investigational

Phase 4

180384-57-0

Calcitonin gene-related peptide

Investigational

Phase 4

83652-28-2

Fibrinolytic Agents

Phase 4

Contraceptive Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Contraceptives, Oral

Phase 4,Phase 3,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Estradiol 17 beta-cypionate

Phase 4,Phase 3,Phase 2,Not Applicable

Estradiol 3-benzoate

Phase 4,Phase 3,Phase 2,Not Applicable

Estrogens

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 1

Androgens

Phase 4,Phase 3

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Serotonin Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Psychotropic Drugs

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Serotonin Uptake Inhibitors

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Antidepressive Agents

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Mineralocorticoid Receptor Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Natriuretic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Mineralocorticoids

Phase 4,Phase 3,Phase 2,Not Applicable

Drospirenone and ethinyl estradiol combination

Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 129)

#	Name	Status	NCT ID	Phase	Drugs
1	Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis	Unknown status	NCT02959801	Phase 4
2	Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives.	Unknown status	NCT01251263	Phase 4	Estradiol or Placebo;Estradiol or Placebo
3	Athena Pelvic Muscle Trainer - DUETS Trial	Completed	NCT01073878	Phase 4
4	Effectiveness of Flutamide in Treating Women With Premenstrual Dysphoric Disorder	Completed	NCT00611923	Phase 4	Flutamide;Placebo
5	Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder	Completed	NCT02048241	Phase 4	Intuniv
6	Atomoxetine, Placebo and Parent Management Training in Autism	Completed	NCT00844753	Phase 4	atomoxetine;Placebo
7	Ultrasound Plus Nerve Stimulator Versus Nerve Stimulator Guided Lumbar Plexus Block	Completed	NCT02020096	Phase 4
8	Treatment of Severe Childhood Aggression (The TOSCA Study)	Completed	NCT00796302	Phase 4	Methylphenidate HCl;Risperidone;Placebo
9	Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder	Completed	NCT00536198	Phase 4	Sertraline;Placebo
10	Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS)	Completed	NCT00318773	Phase 4	sertraline
11	Premenstrual Symptoms Treatment Comparing Between Oral Contraceptives Containing Desogestrel and Drospirenone	Completed	NCT01482338	Phase 4	EE 20 microgram with desogestrel 150 mg;EE 20 microgram with drospirenone 3 mg
12	A Placebo-Controlled Study to Investigate the Onset of Action of Paroxetine in Premenstrual Dysphoria	Completed	NCT00516113	Phase 4	paroxetine
13	The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder	Completed	NCT00678574	Phase 4	fluoxetine
14	Understanding Experimentally Induced Hot Flushes	Completed	NCT00455689	Phase 4	Leuprolide acetate
15	An Investigation of the Safety and Utility of Treximet in the Treatment of Menstrual Migraine	Completed	NCT01578941	Phase 4
16	CGRP, Estrogen, Cortisol, VIP, α-Amylase, PGE2, PGI2 and ß-Endorphin Levels in Menstrual Migraine Before and After Treximet	Completed	NCT01329562	Phase 4	Treximet;Placebo
17	Prospective Survey of Menstrual Migraine & Prevention With Eletriptan	Completed	NCT00259649	Phase 4	eletriptan
18	Chances for Success of CavatermTM Surgery as a Function of Uterus Probe Length	Completed	NCT01436903	Phase 4
19	Effectiveness And Safety Of Frovatriptan For The Management (Acute Treatment) Of Menstrual Migraine	Completed	NCT00904098	Phase 4	Frovatriptan;Usual Care
20	Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD)	Completed	NCT00927095	Phase 4	Continuous OC (EE/DROS);Intermittent OC (EE/DROS);placebo
21	Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients	Recruiting	NCT03452891	Phase 4	Simvastatin-Methylcellulose
22	Progesterone and Brain Imaging Study	Recruiting	NCT01954966	Phase 4	Progesterone;Placebo
23	Escitalopram for Premenstrual Syndrome (PMS) in Teens: A Pilot Study	Terminated	NCT00523705	Phase 4	escitalopram
24	Homeopathic Treatment of Premenstrual Syndrome	Unknown status	NCT02402049	Phase 3	Natrum muriaticum 30C;Lachesis 30C;Sepia 30C;Nux vomica 30C;Pulsatilla 30C;Folliculinum 30C;Placebo Natrum muriaticum;Placebo Lachesis;Placebo Sepia;Placebo Nux vomica;Placebo pulsatilla;Placebo Folliculinum
25	Dienogest Versus Luteal Phase Fluoxetine in the Management of Premenstrual Syndrome	Unknown status	NCT02427334	Phase 3	Dienogest;Fluoxetine;Placebo
26	Does Adding Oral Contraceptives to Fluoxetine Improve the Management of Premenstrual Syndrome?	Unknown status	NCT02562053	Phase 3	Fluoxetine;Combined oral contraceptives;Placebo 1;Placebo 2
27	Combined Oral Contraceptives and Fluoxetine Versus Combined Oral Contraceptives in Severe Premenstrual Syndrome	Unknown status	NCT02488538	Phase 3	Combined oral contraceptives;Fluoxetine;Combined oral contraceptives placebo;Fluoxetine placebo
28	GAMALINE®+HIPERICIN® for PMS Treatment and Vasomotor Symptoms	Unknown status	NCT01365676	Phase 3	GAMALINE® + HIPERICIN®;GAMALINE®
29	Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder	Unknown status	NCT01217775	Phase 3	PH80;Placebo intranasal spray
30	Operations and Pelvic Muscle Training in the Management of Apical Support Loss: The OPTIMAL Trial	Completed	NCT00597935	Phase 3
31	The Impact of Serelys PMS on Symptoms of PMS	Completed	NCT03298607	Phase 3
32	Luteal Phase Administration of Paroxetine for the Treatment of PMDD	Completed	NCT00620581	Phase 3	Paroxetine
33	Comparison Between Oral Contraceptive Pills and Calcium Supplements in Treatment of Premenstrual Syndrome	Completed	NCT02089620	Phase 3	Yasmin;Placebo 1;Placebo 2
34	Dose-dependent Effects of VAC BNO 1095 on Cyclic Mastodynia and Premenstrual Syndrome	Completed	NCT01309113	Phase 3	VAC BNO 1095 film coated tablets
35	Study Evaluating Combination of Levonorgestrel (LNG) and Ethinyl Estradiol (EE) in Premenstrual Dysphoric Disorder	Completed	NCT00128934	Phase 3	levonorgestrel/ethinyl estradiol
36	Study Evaluating Levonorgestrel/Ethinyl Estradiol (LNG/EE) in PMS	Completed	NCT00161681	Phase 3	Levonorgestrel/Ethinyl Estradiol
37	Study Evaluating Combination of Levonorgestrel and Ethinyl Estradiol in Pre-Menstrual Dysphoric Disorder	Completed	NCT00195559	Phase 3	Levonorgestrel/Ethinyl Estradiol
38	Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study	Completed	NCT02508103	Phase 2, Phase 3	Oxytocin;Placebo
39	The Effect of Toremifene Treatment to the Magnetic Resonance Imaging (MRI) Findings in Premenstrual Mastalgia	Completed	NCT00534846	Phase 3	toremifene;placebo
40	Treximet (Sumatriptan/Naproxen Sodium), Formerly Known as TREXIMA, for Menstrual Migraine in Women With Dysmenorrhea	Completed	NCT00329459	Phase 3	sumatriptan succinate/naproxen sodium;placebo
41	Menstrual Migraine Treatment With TREXIMET (Formerly Known as TREXIMA)	Completed	NCT00329355	Phase 3	sumatriptan succinate/naproxen sodium
42	Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder	Completed	NCT01912391	Phase 3	Selegiline;Placebo (for Selegiline)
43	Diindolylmethane in Treating Patients With Abnormal Cervical Cells	Completed	NCT00462813	Phase 3	oral microencapsulated diindolylmethane
44	YAZ Premenstrual Dysphoric Disorder (PMDD) in China	Completed	NCT00824187	Phase 3	EE20/DRSP(YAZ, BAY86-5300);Placebo
45	Efficacy and Safety of 20 mg (2 Tablets of 10mg)VAC BNO 1095 FCT on Cyclic Mastodynia and PMS	Terminated	NCT01870687	Phase 3	20mg VAC BNO 1095 FCT;Placebo
46	Evaluation of Safety/Efficacy of Diagnostic Skin Test Panel and Desensitization Hormone Kit for Treatment of Premenstrual Syndrome (PMS)	Unknown status	NCT00873262	Phase 2	Skin test panel and desensitization kit;Skin test panel and solvent
47	Evaluation of Efficacy/Safety of EVE-PMS Skin Test Panel	Unknown status	NCT00866437	Phase 2	Skin test panel;Skin test panel
48	Antidepressant Treatment for Premenstrual Syndrome and Premenstrual Dysphoric Disorder	Completed	NCT00048854	Phase 1, Phase 2	Sertraline
49	a Clinical Trial to Evaluate the Efficacy and Safety of Agnucaston Tablets in the Treatment of Premenstrual Syndrome (PMS)	Completed	NCT00672607	Phase 2	extracts of Vitex agnus castus tablets;Placebo
50	Auriculotherapy in the Cares to the Premenstrual Syndrome	Completed	NCT01782040	Phase 2

Search NIH Clinical Center for Premenstrual Tension

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

ibuprofen

mefenamic acid

pamabrom

solufenum

Cochrane evidence based reviews: premenstrual syndrome

Sources

Genetic Tests for Premenstrual Tension

Sources

Anatomical Context for Premenstrual Tension

MalaCards organs/tissues related to Premenstrual Tension:

⁴²

Breast, Testes, Skin, Brain, Bone, Cortex, Liver

Sources

Publications for Premenstrual Tension

Articles related to Premenstrual Tension:

(show top 50) (show all 1337)

#	Title	Authors	Year
1	Yoga positively affected depression and blood pressure in women with premenstrual syndrome in a randomized controlled clinical trial. ( 30712751 )	Ghaffarilaleh G...Kamalifard M	2019
2	The association of trace elements with premenstrual syndrome, dysmenorrhea and irritable bowel syndrome in adolescents. ( 30590227 )	Bahrami A...Ghyour-Mobarhan M	2019
3	Diets enriched with whole grains reduce premenstrual syndrome scores in nurses: an open-label parallel-randomized controlled trial. ( 30761961 )	Esmaeilpour M...Alizadeh M	2019
4	Protein intake and the risk of premenstrual syndrome. ( 30774065 )	Houghton SC...Bertone-Johnson ER	2019
5	Effects of a social-media-based support on premenstrual syndrome and physical activity among female university students in South Korea. ( 30829097 )	Nam SJ...Cha C	2019
6	Psychological factors and premenstrual syndrome: A Spanish case-control study. ( 30840651 )	Del Mar Fern?ndez M...Takkouche B	2019
7	The Association Between Serum Magnesium and Premenstrual Syndrome: a Systematic Review and Meta-Analysis of Observational Studies. ( 30880352 )	Moslehi M...Hajianfar H	2019
8	Altered exploratory behaviour and increased food intake in the spiny mouse before menstruation: a unique pre-clinical model for examining premenstrual syndrome. ( 30561655 )	Bellofiore N...Evans J	2019
9	Premenstrual Syndrome, Inflammatory Status, and Mood States in Soccer Players. ( 30654383 )	Foster R...Di-Bella ZIKJ	2019
10	Diet quality in adolescents with premenstrual syndrome: A cross-sectional study. ( 30729645 )	Isgin-Atici K...Buyuktuncer Z	2019
11	Associations between premenstrual syndrome and postpartum depression: A systematic literature review. ( 30452945 )	Amiel Castro RT...Ehlert U	2018
12	Symptoms of premenstrual syndrome in female migraineurs with and without menstrual migraine. ( 30332985 )	Vetvik KG...Russell MB	2018
13	Prevalence of Premenstrual Syndrome and Changes in Blood Pressure with Menstrual Cycle Among University Students. ( 30837763 )	Danborno AM...Eluwa C	2018
14	Prevalence and association of premenstrual syndrome and premenstrual dysphoric disorder with academic performance among female university students. ( 28543046 )	Hussein Shehadeh J...Hamdan-Mansour AM	2018
15	Hippocampal fractional amplitude of low-frequency fluctuation and functional connectivity changes in premenstrual syndrome. ( 28577332 )	Duan G...Deng D	2018
16	Premenstrual syndrome in university students: its correlation with their attitudes toward gender roles. ( 28617173 )	Temel S...Isik Koc G	2018
17	The effect of omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: a randomized clinical trial. ( 28707491 )	Behboudi-Gandevani S...Moghaddam-Banaem L	2018
18	Premenstrual Syndrome Diagnosis: A Comparative Study between the Daily Record of Severity of Problems (DRSP) and the Premenstrual Symptoms Screening Tool (PSST). ( 29132173 )	Henz A...Wender MCO	2018
19	Premenstrual syndrome and premenstrual dysphoric disorders among Jordanian women. ( 29215138 )	Albsoul-Younes A...AlKhatib R	2018
20	Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome. ( 29260367 )	Deng D...Li M	2018
21	Premenstrual Syndrome: Evidence-based Evaluation and Treatment. ( 29298169 )	Appleton SM	2018
22	Investigation of auditory potentials and cognitive impairment in premenstrual syndrome. ( 29305663 )	Ors CH...Karaman HIO	2018
23	Altered brain structure in women with premenstrual syndrome. ( 29329055 )	Liu P...Qin W	2018
24	Effect of swimming exercise on premenstrual syndrome. ( 29350276 )	Maged AM...Kotb A	2018
25	Effect of Melissa officinalis capsule on the mental health of female adolescents with premenstrual syndrome: a clinical trial study. ( 29369810 )	Heydari N...Akbarzadeh M	2018
26	Carbohydrate and fiber intake and the risk of premenstrual syndrome. ( 29379144 )	Houghton SC...Bertone-Johnson ER	2018
27	Treatment of premenstrual syndrome: Appraising the effectiveness of cognitive behavioral therapy in addition to calcium supplement plus vitamin D. ( 29392847 )	Karimi Z...Mohtashami T	2018
28	Low Proportion of Dietary Plant Protein among Athletes with Premenstrual Syndrome-Related Performance Impairment. ( 29434077 )	Yamada K...Takeda T	2018
29	High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and premenstrual syndrome in adolescents. ( 29447494 )	Bahrami A...Ghayour-Mobarhan M	2018
30	Effect of aromatherapy on coping with premenstrual syndrome: A randomized controlled trial. ( 29458934 )	Uzun?akmak T...Ayaz Alkaya S	2018
31	A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial. ( 29576358 )	Schmidt K...Hellhammer J	2018
32	The effectiveness and safety of Iranian herbal medicines for treatment of premenstrual syndrome: A systematic review. ( 29632841 )	Maleki-Saghooni N...Mirzaii Najmabadi K	2018
33	Cortical and subcortical changes in patients with premenstrual syndrome. ( 29656266 )	Liu P...Qin W	2018
34	Premenstrual syndrome and alcohol consumption: a systematic review and meta-analysis. ( 29661913 )	Fern?ndez MDM...Takkouche B	2018
35	Premenstrual syndrome and sleep disturbances: Results from the Sao Paulo Epidemiologic Sleep Study. ( 29704826 )	Nicolau ZFM...Hachul H	2018
36	Premenstrual Syndrome: Existence, Knowledge, and Attitude Among Female University Students in Karachi. ( 29744256 )	Mohib A...Rehman R	2018
37	Thalamocortical dysconnectivity in premenstrual syndrome. ( 29774500 )	Liu P...Qin W	2018
38	Evaluation of aromatherapy with essential oils of Rosa damascena for the management of premenstrual syndrome. ( 29788545 )	Heydari N...Akbarzaded M	2018
39	The effect of 8 weeks aerobic exercise on severity of physical symptoms of premenstrual syndrome: a clinical trial study. ( 29855308 )	Mohebbi Dehnavi Z...Sadeghi Goghary S	2018
40	No Menstrual Cyclicity in Mood and Interpersonal Behaviour in Nine Women with Self-Reported Premenstrual Syndrome. ( 29874668 )	Bosman RC...Aan Het Rot M	2018
41	Altered Brain Regional Homogeneity Following Electro-Acupuncture Stimulation at Sanyinjiao (SP6) in Women With Premenstrual Syndrome. ( 29904344 )	Pang Y...Deng D	2018
42	Factors associated with premenstrual syndrome in Female High School Students. ( 29922693 )	Rad M...Dehnavi ZM	2018
43	Effect of psychosocial interventions on the severity of premenstrual syndrome: a meta-analysis. ( 29962276 )	Han J...Kim S	2018
44	Effect of an educational program on adolescent premenstrual syndrome: lessons from the Great East Japan Earthquake. ( 29988773 )	Takeda T...Shiina M	2018
45	Remote intervention using smartphone for rural women suffering from premenstrual syndrome: A propensity score matched analysis. ( 30024566 )	Chai N...Zhang Y	2018
46	Investigation of the effect of aromatherapy with Citrus aurantium blossom essential oil on premenstrual syndrome in university students: A clinical trial study. ( 30057033 )	Heydari N...Akbarzadeh M	2018
47	Biopsychosocial etiology of premenstrual syndrome: A narrative review. ( 30090776 )	Zendehdel M...Elyasi F	2018
48	Acupuncture and acupressure for premenstrual syndrome. ( 30105749 )	Armour M...Smith CA	2018
49	Relationship between premenstrual syndrome and basic personality traits: a cross-sectional study. ( 30110077 )	Arslanta? H...?inakli ?	2018
50	Primary dysmenorrhea with and without premenstrual syndrome: variation in quality of life over menstrual phases. ( 30209721 )	Quick F...Mirghafourvand M	2018

Sources

Genes for Premenstrual Tension

Genes related to Premenstrual Tension (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	15.82	Novoseek inferred ⁵⁶	9230648 10368798 18407075
2	LIPN	Lipase Family Member N	Protein Coding	14.86	DISEASES inferred ¹⁵
3	MGAM	Maltase-Glucoamylase	Protein Coding	14.72	DISEASES inferred ¹⁵
4	FLCN	Folliculin	Protein Coding	14.59	DISEASES inferred ¹⁵
5	POMC	Proopiomelanocortin	Protein Coding	14.36	DISEASES inferred ¹⁵
6	REN	Renin	Protein Coding	14.26	DISEASES inferred ¹⁵
7	LRP5	LDL Receptor Related Protein 5	Protein Coding	14.06	DISEASES inferred ¹⁵
8	CAMP	Cathelicidin Antimicrobial Peptide	Protein Coding	13.97	DISEASES inferred ¹⁵
9	PGR	Progesterone Receptor	Protein Coding	13.64	DISEASES inferred ¹⁵
10	CRH	Corticotropin Releasing Hormone	Protein Coding	13.41	DISEASES inferred ¹⁵
11	HP	Haptoglobin	Protein Coding	13.39	DISEASES inferred ¹⁵
12	SHBG	Sex Hormone Binding Globulin	Protein Coding	13.36	DISEASES inferred ¹⁵
13	AVP	Arginine Vasopressin	Protein Coding	13.25	DISEASES inferred ¹⁵
14	PRL	Prolactin	Protein Coding	13.11	DISEASES inferred ¹⁵
15	SERPINE1	Serpin Family E Member 1	Protein Coding	12.94	DISEASES inferred ¹⁵
16	PNN	Pinin, Desmosome Associated Protein	Protein Coding	6.3	DISEASES inferred ¹⁵
17	MTRNR2L5	MT-RNR2 Like 5	Protein Coding	5.28	DISEASES inferred ¹⁵
18	SP6	Sp6 Transcription Factor	Protein Coding	4.82	DISEASES inferred ¹⁵
19	KANTR	KDM5C Adjacent Transcript	RNA Gene	4.03	DISEASES inferred ¹⁵
20	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	3.67	DISEASES inferred ¹⁵

Sources

Variations for Premenstrual Tension

Sources

Expression for Premenstrual Tension

Search GEO for disease gene expression data for Premenstrual Tension.

Sources

Pathways for Premenstrual Tension

Pathways related to Premenstrual Tension according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Nongenotropic Androgen signaling ¹	10.21	GNRH1 SHBG
2	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶²	9.47	CRH POMC

Sources

GO Terms for Premenstrual Tension

Cellular components related to Premenstrual Tension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.65	AVP CAMP CRH GNRH1 HP OXT
2	extracellular region	GO:0005576	9.44	AVP CAMP CRH GNRH1 HP LIPN
3	secretory granule	GO:0030141	9.33	AVP OXT POMC

Biological processes related to Premenstrual Tension according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.96	AVP CAMP CRH LRP5 PRL
2	cell-cell signaling	GO:0007267	9.8	AVP GNRH1 PGR POMC
3	regulation of blood pressure	GO:0008217	9.61	LRP5 POMC REN
4	grooming behavior	GO:0007625	9.55	AVP OXT
5	maternal behavior	GO:0042711	9.54	AVP OXT
6	drinking behavior	GO:0042756	9.48	OXT REN
7	response to prostaglandin E	GO:0034695	9.46	GNRH1 OXT
8	response to organic cyclic compound	GO:0014070	9.43	AVP GNRH1 OXT
9	regulation of signaling receptor activity	GO:0010469	9.43	AVP GNRH1 OXT POMC PRL SERPINE1
10	hyperosmotic salinity response	GO:0042538	9.4	AVP OXT
11	maternal aggressive behavior	GO:0002125	9.37	AVP OXT
12	response to ethanol	GO:0045471	9.33	AVP CRH GNRH1
13	response to ether	GO:0045472	9.32	CRH OXT
14	parturition	GO:0007567	9.22	CRH
15	ovulation cycle	GO:0042698	9.21	GNRH1
16	female pregnancy	GO:0007565	8.92	CRH GNRH1 OXT PRL

Molecular functions related to Premenstrual Tension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.65	AVP CRH POMC REN SERPINE1
2	neuropeptide hormone activity	GO:0005184	9.33	AVP CRH OXT
3	hormone activity	GO:0005179	9.1	AVP CRH GNRH1 OXT POMC PRL
4	neurohypophyseal hormone activity	GO:0005185	8.96	AVP OXT

Sources

Sources for Premenstrual Tension

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Premenstrual Tension

Aliases & Classifications for Premenstrual Tension

MalaCards integrated aliases for Premenstrual Tension:

Classifications:

External Ids:

Summaries for Premenstrual Tension

Related Diseases for Premenstrual Tension

Diseases related to Premenstrual Tension via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Premenstrual Tension:

Symptoms & Phenotypes for Premenstrual Tension

UMLS symptoms related to Premenstrual Tension:

MGI Mouse Phenotypes related to Premenstrual Tension:

Drugs & Therapeutics for Premenstrual Tension

PubMedHealth treatment related to Premenstrual Tension: 64

Drugs for Premenstrual Tension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: premenstrual syndrome

Genetic Tests for Premenstrual Tension

Anatomical Context for Premenstrual Tension

MalaCards organs/tissues related to Premenstrual Tension:

Publications for Premenstrual Tension

Articles related to Premenstrual Tension:

Genes for Premenstrual Tension

Genes related to Premenstrual Tension (0 elite genes):

Variations for Premenstrual Tension

Expression for Premenstrual Tension

Pathways for Premenstrual Tension

Pathways related to Premenstrual Tension according to GeneCards Suite gene sharing:

GO Terms for Premenstrual Tension

Cellular components related to Premenstrual Tension according to GeneCards Suite gene sharing:

Biological processes related to Premenstrual Tension according to GeneCards Suite gene sharing:

Molecular functions related to Premenstrual Tension according to GeneCards Suite gene sharing:

Sources for Premenstrual Tension

PubMedHealth treatment related to Premenstrual Tension: ⁶⁴

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :