Aliases & Classifications for Presbyopia

MalaCards integrated aliases for Presbyopia:

Name: Presbyopia 12 77 45 15 64 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11638
ICD9CM 36 367.4
MeSH 45 D011305
SNOMED-CT 69 41256004
ICD10 34 H52.4
UMLS 74 C0033075

Summaries for Presbyopia

PubMed Health : 64 About presbyopia: It happens to all of us eventually: You have to start holding newspapers or books further away in order to be able to read them and clearly recognize letters without straining your eyes.Seeing nearby objects less clearly is a normal part of aging. Known as presbyopia, this typically becomes noticeable in your mid-forties.Although there are no effective treatments for the causes of presbyopia, the effects can be corrected. The best and easiest way to do so is using reading glasses.

MalaCards based summary : Presbyopia is related to cycloplegia and cataract, and has symptoms including aniseikonia An important gene associated with Presbyopia is MIP (Major Intrinsic Protein Of Lens Fiber). The drugs Dipivefrin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Wikipedia : 77 Presbyopia is a condition associated with the aging of the eye that results in progressively worsening... more...

Related Diseases for Presbyopia

Diseases related to Presbyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 cycloplegia 31.6 CRYAA CTSC
2 cataract 29.8 BFSP2 CRYAA CRYGS MIP
3 refractive error 11.7
4 myopia 10.6
5 astigmatism 10.4
6 aging 10.3
7 farsightedness 10.2
8 early-onset nuclear cataract 10.0 CRYAA MIP
9 cataract 44 10.0 CRYAA MIP
10 ocular dominance 10.0
11 strabismus 10.0
12 monocular esotropia 10.0
13 alternating exotropia 10.0
14 exotropia 10.0
15 corneal ectasia 10.0
16 amyloidosis 10.0
17 mechanical strabismus 10.0
18 esotropia 10.0
19 monofixation syndrome 10.0
20 nuclear senile cataract 9.9 CRYAA CRYGS
21 mature cataract 9.8 CRYAA CRYGS MIP
22 lens disease 9.7 CRYAA CRYGS
23 cataract 25 9.5 BFSP2 CRYGS MIP
24 cataract 16, multiple types 9.3 BFSP2 CRYAA CRYGS MIP
25 eye accommodation disease 8.2 BFSP2 CPNE6 CRYAA CRYGS CTSC HIVEP3

Graphical network of the top 20 diseases related to Presbyopia:



Diseases related to Presbyopia

Symptoms & Phenotypes for Presbyopia

UMLS symptoms related to Presbyopia:


aniseikonia

Drugs & Therapeutics for Presbyopia

PubMedHealth treatment related to Presbyopia: 64

Although there are no effective treatments to fight the cause of presbyopia, the effects of presbyopia are easily corrected. The easiest way to solve the problem of not being able to see nearby objects is wearing ready-made reading glasses available in shops. But these readily available reading glasses don't account for possible differences in vision between your eyes or other features, such as astigmatism (an irregularly shaped cornea). Individually adjusted prescription reading glasses are only available from an optician's, where glasses with the required lens power are made especially based on the results of an eye test. The distance between the pupils of your eyes and other factors are also taken into account. Reading glasses are often narrow enough for you to be able to look over them if you want to see things that are further away.If you already wore prescription glasses before presbyopia started becoming an issue, multifocals are an option. Bifocal glasses (bifocals) are one type of multifocal glasses. They have two zones divided in the middle by a visible horizontal line. The lower half of the glasses is for looking at nearby objects, and the upper half is for looking at objects that are further away. Trifocals have a visibly separate third zone for seeing objects at intermediate distances too. In varifocals (also known as progressive lenses), the lines dividing the different zones have been smoothly polished so you can’t see them. They are the most common kind of glasses.

Drugs for Presbyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
2 Alkylating Agents Phase 4
3 Nucleic Acid Synthesis Inhibitors Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Anti-Bacterial Agents Phase 4
6 Mitomycins Phase 4
7 Vitamins Phase 4
8 Omega 3 Fatty Acid Phase 4
9 Ophthalmic Solutions Phase 3,Phase 2,Phase 1
10 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Not Applicable
11
Tropicamide Approved, Investigational Phase 2 1508-75-4 5593
12
Choline Approved, Nutraceutical Phase 2 62-49-7 305
13 Thioctic Acid Phase 2
14 Alpha-lipoic Acid Phase 2
15
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
16
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
17
Pilocarpine Approved, Investigational Not Applicable,Early Phase 1 54-71-7, 92-13-7 5910
18
Hydrogen peroxide Approved, Vet_approved Not Applicable 7722-84-1 784
19
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
20
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
21
Meclocycline Experimental, Investigational Not Applicable 2013-58-3 5480760
22 Autonomic Agents Not Applicable,Early Phase 1
23 Dopamine Uptake Inhibitors Not Applicable
24 Peripheral Nervous System Agents Not Applicable,Early Phase 1
25 Adrenergic Agents Not Applicable,Early Phase 1
26 Neurotransmitter Agents Not Applicable,Early Phase 1
27 Dopamine Agents Not Applicable
28 Sympathomimetics Not Applicable
29 Neurotransmitter Uptake Inhibitors Not Applicable
30 Central Nervous System Stimulants Not Applicable
31 Cholinergic Agents Not Applicable,Early Phase 1
32 Muscarinic Agonists Not Applicable,Early Phase 1
33 Tetrahydrozoline Not Applicable
34 Tea Not Applicable
35 Anti-Infective Agents Not Applicable
36 Contact Lens Solutions Not Applicable
37 Anti-Infective Agents, Local Not Applicable
38 Disinfectants Not Applicable
39 Anesthetics Not Applicable
40 Dermatologic Agents Not Applicable
41 Antifungal Agents Not Applicable
42 Keratolytic Agents Not Applicable
43 Central Nervous System Depressants Not Applicable
44 Adrenergic alpha-Agonists Early Phase 1
45 Adrenergic Agonists Early Phase 1
46 Adrenergic alpha-2 Receptor Agonists Early Phase 1
47 Brimonidine Tartrate Early Phase 1 70359-46-5
48 Antihypertensive Agents Early Phase 1
49 Polymethyl Methacrylate Not Applicable

Interventional clinical trials:

(show top 50) (show all 165)
# Name Status NCT ID Phase Drugs
1 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
2 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
3 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
4 Presbyopia-Correcting Intraocular Lenses (IOLs) Completed NCT00963560 Phase 4
5 A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs) Completed NCT01166971 Phase 4
6 Clinical Evaluation of Biofinity Multifocal Compared With Air Optix Aqua Multifocal and With PureVision Multifocal Completed NCT01591499 Phase 4
7 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
8 Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses Completed NCT01061281 Phase 4
9 Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL Completed NCT01275118 Phase 4
10 Visual Performance After RESTOR Implantation Completed NCT01065064 Phase 4
11 A Study to Evaluate the Raindrop Near Vision Inlay Under Flap or Within Pocket Recruiting NCT03376412 Phase 4
12 A Prospective Study to Evaluate the Raindrop Near Vision Inlay With Mitomycin C Recruiting NCT03242317 Phase 4 Mitomycin C
13 A Prospective Study to Evaluate the Raindrop Near Vision Inlay in Presbyopic Patients With Treatments to Optimize the Ocular Surface Before Implantation Recruiting NCT03126877 Phase 4 Mitomycin C
14 A Study Raindrop Near Vision Inlay in Presbyopes Implanted in Corneal Pockets Suspended NCT03326869 Phase 4
15 A Prospective Study To Evaluate The Raindrop Near Vision Inlay In Presybopic or Pseudophakic Patients Treated With Mitomycin C Following Femtosecond Flap Creation. Terminated NCT03101501 Phase 4 Mitomycin c
16 LaserACE® Procedure Restore Visual Function and Range of Accommodation LaserACE® Procedure Unknown status NCT01491360 Phase 3
17 A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects Unknown status NCT02668523 Phase 3
18 Investigation of the Presbia Flexivue Microlens™ Unknown status NCT02110472 Phase 3
19 SUPRACOR for Myopia and Myopic Astigmatism Unknown status NCT01404884 Phase 3
20 Intrastromal Correction of Ametropia by a Femtosecond Laser Unknown status NCT00928122 Phase 3
21 Intrastromal Presbyopia Correction by Means of a Femtosecond Laser Completed NCT01025050 Phase 3
22 Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes Completed NCT00910403 Phase 3
23 Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure Completed NCT01322919 Phase 3
24 Phase 3 Efficacy Study of AGN-190584 in Participants With Presbyopia Recruiting NCT03804268 Phase 3 AGN-190584;Vehicle
25 A Phase 3 Efficacy Study of AGN-190584 in Participants With Presbyopia Recruiting NCT03857542 Phase 3 AGN-190584
26 Clinical Evaluation of the Lenstec SBL-3 Multifocal Intraocular Lens Active, not recruiting NCT02487160 Phase 3
27 Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses Terminated NCT00585026 Phase 3
28 A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed NCT03201562 Phase 2 PRX-100;PRX-100 Component #1;PRX-100 Vehicle
29 A Study to Evaluate the Safety and Efficacy of EV06 Ophthalmic Solution in Improving Vision in Subjects With Presbyopia Completed NCT02516306 Phase 1, Phase 2 EV06 Ophthalmic Solution;Placebo Ophthalmic Solution
30 A Safety, Efficacy and Pharmacokinetic Study of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02780115 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-199201 Vehicle;AGN-190584 Vehicle
31 A Study of the Concurrent Use of AGN-190584 and AGN-199201 in Participants With Presbyopia Completed NCT02595528 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-190584 vehicle;AGN-199201 + AGN-190584 Combination;AGN-199201 vehicle
32 Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed NCT02554396 Phase 2 PRX-100;Placebo
33 Safety and Efficacy of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02197806 Phase 2 AGN-199201;AGN-190584;AGN-199201 Vehicle
34 Safety, Tolerability, and Efficacy of PresbiDrops (CSF-1), a Topical Ophthalmic Drug for Presbyopia Completed NCT02745223 Phase 2 PresbiDrops (CSF-1);Placebo
35 Safety, Tolerability and Efficacy of PresbiDrops (CSF-1) in Presbyopic Subjects Completed NCT02965664 Phase 2 PresbiDrops (CSF-1);Placebo
36 A Multi-Center, Double-Masked Evaluation of the Efficacy and Safety of CSF-1 in the Treatment of Presbyopia Recruiting NCT03885011 Phase 2 CSF-1;CSF-1 Component #1;CSF-1 Component #2
37 A Study of Safety and Efficacy of UNR844 Chloride (UNR844-Cl) Eye Drops in Subjects With Presbyopia. Not yet recruiting NCT03809611 Phase 2 UNR844-Cl;Placebo
38 Presbyopia Compensation: Looking for Electrophysiological Predictors Unknown status NCT02444130
39 Functional and Physiological Changes Induced by Pinhole Glasses in Presbyopia Unknown status NCT02722291 Not Applicable
40 The Effect of Cataract Extraction on the Contractility of Ciliary Muscle Unknown status NCT00624039 Not Applicable
41 Functional Assessment of Activities of Daily Living (ADL) in Patients Who Underwent Mini-monovision Correction Unknown status NCT02431156
42 Visual and Economic Profits of ReSTOR® Multifocal Intraocular Lenses (IOL) on Public Health Patients in Spain Unknown status NCT01088282 Not Applicable
43 Functional Assessment of ADL in Patients Who Underwent Bifocal and Trifocal Presbyopic Correction Unknown status NCT03021512
44 Clinical Evaluation of a Progressive Addition Lens (PAL) Unknown status NCT01443585 Not Applicable
45 Study to Evaluate the Safety and Efficacy of HI-BRITE Large Diameter Rigid Gas Permeable Contact Lens Unknown status NCT02812316 Not Applicable
46 Mix and Match Study of Two Multifocal Intraocular Lens With Different Add Power Unknown status NCT02556944 Not Applicable
47 Assessment of Near Vision Capacity in Different Light Intensities Unknown status NCT03024073
48 Development of a Validated Chart for Intermediate Vision Assessment Unknown status NCT02279446
49 Study to Evaluate the Clinical Performance of SynergEyes A2 Hybrid Contact Lenses Unknown status NCT01058629 Not Applicable
50 Presbyopia Screening by Community Health Worker in Bangladesh Completed NCT03001258

Search NIH Clinical Center for Presbyopia

Cochrane evidence based reviews: presbyopia

Genetic Tests for Presbyopia

Anatomical Context for Presbyopia

MalaCards organs/tissues related to Presbyopia:

42
Eye, Testes, Cortex

Publications for Presbyopia

Articles related to Presbyopia:

(show top 50) (show all 513)
# Title Authors Year
1
Latanoprost could exacerbate the progression of presbyopia. ( 30703139 )
2019
2
Pinholes and presbyopia: solution or sideshow? ( 30628739 )
2019
3
Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries. ( 30469062 )
2019
4
Near Vision Improvement with the Use of a New Topical Compound for Presbyopia Correction: A Prospective, Consecutive Interventional Non-Comparative Clinical Study. ( 30465236 )
2019
5
Clinical feasibility of pinhole glasses in presbyopia. ( 30460857 )
2019
6
Effects of Display Curvature, Presbyopia, and Task Duration on Visual Fatigue, Task Performance, and User Satisfaction. ( 30281334 )
2019
7
Presbyopia: Effectiveness of correction strategies. ( 30244049 )
2019
8
Outcomes of presbyopia-correcting intraocular lenses after laser in situ keratomileusis. ( 29594789 )
2019
9
Influence of presbyopia on smartphone usage among Chinese adults: a population study. ( 31090978 )
2019
10
Adaptive eyeglasses for presbyopia correction: an original variable-focus technology. ( 31052911 )
2019
11
Presbyopia and Glaucoma: Two Diseases, One Pathophysiology? The Friedenwald Lecture. ( 31038661 )
2019
12
Small-aperture strategies for the correction of presbyopia. ( 31033734 )
2019
13
Prevalence of refractive errors, uncorrected refractive error, and presbyopia in adults in India: A systematic review. ( 31007213 )
2019
14
A Modified Syringe Plunger Device Significantly Reduces Guidewire Threading Time Regardless of Experience Level or the Presence of Presbyopia. ( 31006303 )
2019
15
Intraocular lens correction of presbyopia. ( 30993062 )
2019
16
Clinical Efficacy of Pinhole Soft Contact Lenses for the Correction of Presbyopia. ( 30865475 )
2019
17
Refractive corneal inlay for presbyopia in emmetropic patients in Asia: 6-month clinical outcomes. ( 30836950 )
2019
18
The Light Sword Lens - A novel method of presbyopia compensation: Pilot clinical study. ( 30716136 )
2019
19
Visual quality after presbyopia correction with excimer laser ablation using micromonovision and modulation of spherical aberration. ( 30713017 )
2019
20
Impact of Presbyopia and Its Correction in Low- and Middle-Income Countries. ( 30523677 )
2018
21
Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia. ( 30372745 )
2018
22
Correction of presbyopia: An integrated update for the practical surgeon. ( 30294526 )
2018
23
Presbyopia and the Sustainable Development Goals. ( 30223980 )
2018
24
Presbyopia and Ocular Conditions Causing Near Vision Impairment in Older Adults From the Brazilian Amazon Region. ( 30118685 )
2018
25
From Presbyopia to Cataracts: A Critical Review on Dysfunctional Lens Syndrome. ( 30050689 )
2018
26
Presbyopia and the Sustainable Development Goals. ( 30049616 )
2018
27
Effect of providing near glasses on productivity among rural Indian tea workers with presbyopia (PROSPER): a randomised trial. ( 30049615 )
2018
28
Intentional Undercorrection by Implantation of Posterior Chamber Phakic Intraocular Lens With A Central Hole (Hole ICL) For Early Presbyopia. ( 29984242 )
2018
29
Global Prevalence of Presbyopia and Vision Impairment from Uncorrected Presbyopia: Systematic Review, Meta-analysis, and Modelling. ( 29753495 )
2018
30
Corneal Inlays for Presbyopia Explanted Due to Corneal Haze. ( 29738595 )
2018
31
Erratum: Review of Static Approaches to Surgical Correction of Presbyopia. ( 29722364 )
2018
32
Revisiting monovision for presbyopia. ( 29708928 )
2018
33
Extended depth of focus intraocular lenses for presbyopia. ( 29697436 )
2018
34
Commentary: Presbyopia correction with intraocular lenses. ( 29676324 )
2018
35
Through-Focus Vision Performance and Light Disturbances of 3 New Intraocular Lenses for Presbyopia Correction. ( 29651343 )
2018
36
Simulation of the Effect of Different Presbyopia-Correcting Intraocular Lenses With Eyes With Previous Laser Refractive Surgery. ( 29634836 )
2018
37
Effect of unifocal versus multifocal lenses on cervical spine posture in patients with presbyopia. ( 29616886 )
2018
38
Light disturbance with multifocal contact lens and monovision for presbyopia. ( 29576438 )
2018
39
Scleral surgery for the treatment of presbyopia: where are we today? ( 29497624 )
2018
40
Fundamentals of Presbyopia: visual processing and binocularity in its transformation. ( 29417087 )
2018
41
Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE). ( 29382905 )
2018
42
Prevalence and incidence of presbyopia in urban Southern China. ( 29367202 )
2018
43
Pupil size stability of the cubic phase mask solution for presbyopia. ( 29297211 )
2018
44
Vision improvement in pilots with presbyopia following perceptual learning. ( 29154795 )
2018
45
Presbyopia monovision correction and cortical adaptation. ( 29152742 )
2018
46
Small incision lenticule extraction (SMILE) monovision for presbyopia correction. ( 29148031 )
2018
47
Prevalence of refractive error, presbyopia, and unmet need of spectacle coverage in a northern district of Bangladesh: Rapid Assessment of Refractive Error study. ( 28976783 )
2018
48
Short-term visual outcome after unilateral implantation of a trifocal diffractive presbyopia-correcting intraocular lens. ( 28889556 )
2018
49
Refraction during incipient presbyopia: The Aston Longitudinal Assessment of Presbyopia (ALAP) study. ( 28599911 )
2018
50
Keratectasia After Presbyopia Treatment With INTRACOR. ( 27755289 )
2018

Variations for Presbyopia

Expression for Presbyopia

Search GEO for disease gene expression data for Presbyopia.

Pathways for Presbyopia

GO Terms for Presbyopia

Biological processes related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.33 BFSP2 CRYAA MIP
2 visual perception GO:0007601 8.8 BFSP2 CRYAA MIP
3 lens development in camera-type eye GO:0002088 8.65 CRYGS

Molecular functions related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.92 BFSP2 CRYAA CRYGS MIP

Sources for Presbyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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