Aliases & Classifications for Presbyopia

MalaCards integrated aliases for Presbyopia:

Name: Presbyopia 12 76 44 15 63 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11638
ICD10 33 H52.4
ICD9CM 35 367.4
MeSH 44 D011305
SNOMED-CT 68 155135005 41256004
UMLS 73 C0033075

Summaries for Presbyopia

PubMed Health : 63 About presbyopia: It happens to all of us eventually: You have to start holding newspapers or books further away in order to be able to read them and clearly recognize letters without straining your eyes.Seeing nearby objects less clearly is a normal part of aging. Known as presbyopia, this typically becomes noticeable in your mid-forties.Although there are no effective treatments for the causes of presbyopia, the effects can be corrected. The best and easiest way to do so is using reading glasses.

MalaCards based summary : Presbyopia is related to cycloplegia and cataract, and has symptoms including aniseikonia An important gene associated with Presbyopia is CRYAA (Crystallin Alpha A). The drugs Dipivefrin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Wikipedia : 76 Presbyopia is a condition associated with the aging of the eye that results in progressively worsening... more...

Related Diseases for Presbyopia

Diseases related to Presbyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 cycloplegia 31.4 CRYAA CTSC
2 cataract 28.3 BFSP2 CRYAA CRYGS MIP
3 refractive error 11.5
4 aging 10.5
5 myopia 10.3
6 astigmatism 10.3
7 early-onset nuclear cataract 10.1 CRYAA MIP
8 retinitis 10.0
9 cataract 44 10.0 CRYAA MIP
10 nuclear senile cataract 9.9 CRYAA CRYGS
11 ocular dominance 9.8
12 strabismus 9.8
13 alternating exotropia 9.8
14 exotropia 9.8
15 corneal ectasia 9.8
16 cervicitis 9.8
17 amyloidosis 9.8
18 esotropia 9.8
19 monofixation syndrome 9.8
20 hereditary amyloidosis 9.8
21 mature cataract 9.6 CRYAA CRYGS MIP
22 lens disease 9.6 CRYAA CRYGS MIP
23 blood group, globoside system 9.4 CRYAA CRYGS
24 cataract 25 9.0 BFSP2 CRYGS MIP
25 cataract 16, multiple types 8.7 BFSP2 CRYAA CRYGS MIP
26 eye accommodation disease 6.4 BFSP2 CPNE6 CRYAA CRYGS CTSC HIVEP3

Graphical network of the top 20 diseases related to Presbyopia:



Diseases related to Presbyopia

Symptoms & Phenotypes for Presbyopia

UMLS symptoms related to Presbyopia:


aniseikonia

Drugs & Therapeutics for Presbyopia

PubMedHealth treatment related to Presbyopia: 63

Although there are no effective treatments to fight the cause of presbyopia, the effects of presbyopia are easily corrected. The easiest way to solve the problem of not being able to see nearby objects is wearing ready-made reading glasses available in shops. But these readily available reading glasses don't account for possible differences in vision between your eyes or other features, such as astigmatism (an irregularly shaped cornea). Individually adjusted prescription reading glasses are only available from an optician's, where glasses with the required lens power are made especially based on the results of an eye test. The distance between the pupils of your eyes and other factors are also taken into account. Reading glasses are often narrow enough for you to be able to look over them if you want to see things that are further away.If you already wore prescription glasses before presbyopia started becoming an issue, multifocals are an option. Bifocal glasses (bifocals) are one type of multifocal glasses. They have two zones divided in the middle by a visible horizontal line. The lower half of the glasses is for looking at nearby objects, and the upper half is for looking at objects that are further away. Trifocals have a visibly separate third zone for seeing objects at intermediate distances too. In varifocals (also known as progressive lenses), the lines dividing the different zones have been smoothly polished so you can’t see them. They are the most common kind of glasses.

Drugs for Presbyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
2 Alkylating Agents Phase 4
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Mitomycins Phase 4
6 Nucleic Acid Synthesis Inhibitors Phase 4
7 Vitamins Phase 4
8 Omega 3 Fatty Acid Nutraceutical Phase 4
9
Tropicamide Approved, Investigational Phase 2 1508-75-4 5593
10 Ophthalmic Solutions Phase 1, Phase 2,Phase 2
11 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2,Not Applicable
12
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
13
Menthol Approved Not Applicable 2216-51-5 16666
14
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
15
Meclocycline Approved, Investigational Not Applicable 2013-58-3 5480760
16
Pilocarpine Approved, Investigational Not Applicable 54-71-7, 92-13-7 5910
17
Hydrogen peroxide Approved, Vet_approved Not Applicable 7722-84-1 784
18
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
19
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
20 Adrenergic Agents Not Applicable
21 Autonomic Agents Not Applicable
22 Central Nervous System Stimulants Not Applicable
23 Dopamine Agents Not Applicable
24 Dopamine Uptake Inhibitors Not Applicable
25 Neurotransmitter Agents Not Applicable
26 Neurotransmitter Uptake Inhibitors Not Applicable
27 Peripheral Nervous System Agents Not Applicable
28 Cholinergic Agents Not Applicable
29 Tetrahydrozoline Not Applicable
30 Anti-Infective Agents Not Applicable
31 Contact Lens Solutions Not Applicable
32 Disinfectants Not Applicable
33 Anesthetics Not Applicable
34 Antifungal Agents Not Applicable
35 Dermatologic Agents Not Applicable
36 Keratolytic Agents Not Applicable
37 Polymethyl Methacrylate Not Applicable
38 Tea Nutraceutical Not Applicable

Interventional clinical trials:

(show top 50) (show all 135)
# Name Status NCT ID Phase Drugs
1 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
2 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
3 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
4 Presbyopia-Correcting Intraocular Lenses (IOLs) Completed NCT00963560 Phase 4
5 A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs) Completed NCT01166971 Phase 4
6 Clinical Evaluation of Biofinity Multifocal Compared With Air Optix Aqua Multifocal and With PureVision Multifocal Completed NCT01591499 Phase 4
7 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
8 Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses Completed NCT01061281 Phase 4
9 Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL Completed NCT01275118 Phase 4
10 Visual Performance After RESTOR Implantation Completed NCT01065064 Phase 4
11 A Study to Evaluate the Raindrop Near Vision Inlay Under Flap or Within Pocket Recruiting NCT03376412 Phase 4
12 A Prospective Study to Evaluate the Raindrop Near Vision Inlay With Mitomycin C Recruiting NCT03242317 Phase 4 Mitomycin C
13 A Prospective Study to Evaluate the Raindrop Near Vision Inlay in Presbyopic Patients With Treatments to Optimize the Ocular Surface Before Implantation Recruiting NCT03126877 Phase 4 Mitomycin C
14 A Study Raindrop Near Vision Inlay in Presbyopes Implanted in Corneal Pockets Suspended NCT03326869 Phase 4
15 A Prospective Study To Evaluate The Raindrop Near Vision Inlay In Presybopic or Pseudophakic Patients Treated With Mitomycin C Following Femtosecond Flap Creation. Terminated NCT03101501 Phase 4 Mitomycin c
16 LaserACE® Procedure Restore Visual Function and Range of Accommodation LaserACE® Procedure Unknown status NCT01491360 Phase 3
17 Evaluation of the FluidVision Accommodating Lens Unknown status NCT02049567 Phase 2, Phase 3
18 SUPRACOR for Myopia and Myopic Astigmatism Unknown status NCT01404884 Phase 3
19 Intrastromal Correction of Ametropia by a Femtosecond Laser Unknown status NCT00928122 Phase 3
20 Intrastromal Presbyopia Correction by Means of a Femtosecond Laser Completed NCT01025050 Phase 3
21 Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes Completed NCT00910403 Phase 3
22 Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure Completed NCT01322919 Phase 3
23 A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects Recruiting NCT02668523 Phase 3
24 Clinical Evaluation of the Lenstec SBL-3 Multifocal Intraocular Lens Recruiting NCT02487160 Phase 2, Phase 3
25 Evaluation of the FluidVisionTM AIOL With an Improved Injector Active, not recruiting NCT02418871 Phase 3
26 Investigation of the Presbia Flexivue Microlens™ Active, not recruiting NCT02110472 Phase 3
27 Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses Terminated NCT00585026 Phase 3
28 A Study to Evaluate the Safety and Efficacy of EV06 Ophthalmic Solution in Improving Vision in Subjects With Presbyopia Completed NCT02516306 Phase 1, Phase 2 EV06 Ophthalmic Solution;Placebo Ophthalmic Solution
29 A Safety, Efficacy and Pharmacokinetic Study of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02780115 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-199201 Vehicle;AGN-190584 Vehicle
30 A Study of the Concurrent Use of AGN-190584 and AGN-199201 in Participants With Presbyopia Completed NCT02595528 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-190584 vehicle;AGN-199201 + AGN-190584 Combination;AGN-199201 vehicle
31 Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed NCT02554396 Phase 2 PRX-100;Placebo
32 Safety and Efficacy of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02197806 Phase 2 AGN-199201;AGN-190584;AGN-199201 Vehicle
33 Safety, Tolerability, and Efficacy of PresbiDrops (CSF-1), a Topical Ophthalmic Drug for Presbyopia Completed NCT02745223 Phase 2 PresbiDrops (CSF-1);Placebo
34 Safety, Tolerability and Efficacy of PresbiDrops (CSF-1) in Presbyopic Subjects Completed NCT02965664 Phase 2 PresbiDrops (CSF-1);Placebo
35 A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Recruiting NCT03201562 Phase 2 PRX-100;PRX-100 Component #1;PRX-100 Vehicle
36 Presbyopia Compensation: Looking for Electrophysiological Predictors Unknown status NCT02444130
37 Clinical Efficacy of the Pinhole Soft Contact Lenses for Correcting Presbyopia Unknown status NCT02612584 Not Applicable
38 Functional and Physiological Changes Induced by Pinhole Glasses in Presbyopia Unknown status NCT02722291 Not Applicable
39 The Effect of Cataract Extraction on the Contractility of Ciliary Muscle Unknown status NCT00624039 Not Applicable
40 Functional Assessment of Activities of Daily Living (ADL) in Patients Who Underwent Mini-monovision Correction Unknown status NCT02431156
41 Visual and Economic Profits of ReSTOR® Multifocal Intraocular Lenses (IOL) on Public Health Patients in Spain Unknown status NCT01088282 Not Applicable
42 Clinical Evaluation of a Progressive Addition Lens (PAL) Unknown status NCT01443585 Not Applicable
43 Mix and Match Study of Two Multifocal Intraocular Lens With Different Add Power Unknown status NCT02556944 Not Applicable
44 Development of a Validated Chart for Intermediate Vision Assessment Unknown status NCT02279446
45 Study to Evaluate the Clinical Performance of SynergEyes A2 Hybrid Contact Lenses Unknown status NCT01058629 Not Applicable
46 Presbyopia Screening by Community Health Worker in Bangladesh Completed NCT03001258
47 Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00 Completed NCT02529488 Not Applicable
48 The VEPRO Trial: A Cross-Over Randomised Controlled Trial Comparing 2 Corrective Lenses for Patients With Presbyopia Completed NCT00635115 Not Applicable
49 PROductivity Study of Presbyopia Elimination in Rural-dwellers (PROSPER) Completed NCT03228199 Not Applicable
50 A Comparison of Visual Function After Bilateral Implantation of Presbyopia-Correcting Intraocular Lenses (IOLs) Completed NCT01257217 Not Applicable

Search NIH Clinical Center for Presbyopia

Cochrane evidence based reviews: presbyopia

Genetic Tests for Presbyopia

Anatomical Context for Presbyopia

MalaCards organs/tissues related to Presbyopia:

41
Eye, Testes, Cortex

Publications for Presbyopia

Articles related to Presbyopia:

(show top 50) (show all 470)
# Title Authors Year
1
Revisiting monovision for presbyopia. ( 29708928 )
2018
2
Effect of unifocal versus multifocal lenses on cervical spine posture in patients with presbyopia. ( 29616886 )
2018
3
Fundamentals of Presbyopia: visual processing and binocularity in its transformation. ( 29417087 )
2018
4
Extended depth of focus intraocular lenses for presbyopia. ( 29697436 )
2018
5
Commentary: Presbyopia correction with intraocular lenses. ( 29676324 )
2018
6
Outcomes of presbyopia-correcting intraocular lenses after laser in situ keratomileusis. ( 29594789 )
2018
7
Corneal Inlays for Presbyopia Explanted Due to Corneal Haze. ( 29738595 )
2018
8
Through-Focus Vision Performance and Light Disturbances of 3 New Intraocular Lenses for Presbyopia Correction. ( 29651343 )
2018
9
Light disturbance with multifocal contact lens and monovision for presbyopia. ( 29576438 )
2018
10
Global Prevalence of Presbyopia and Vision Impairment from Uncorrected Presbyopia: Systematic Review, Meta-analysis, and Modelling. ( 29753495 )
2018
11
Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE). ( 29382905 )
2018
12
Presbyopia monovision correction and cortical adaptation. ( 29152742 )
2018
13
Simulation of the Effect of Different Presbyopia-Correcting Intraocular Lenses With Eyes With Previous Laser Refractive Surgery. ( 29634836 )
2018
14
Prevalence and incidence of presbyopia in urban Southern China. ( 29367202 )
2018
15
Scleral surgery for the treatment of presbyopia: where are we today? ( 29497624 )
2018
16
Prevalence of refractive error, presbyopia, and unmet need of spectacle coverage in a northern district of Bangladesh: Rapid Assessment of Refractive Error study. ( 28976783 )
2018
17
Erratum: Review of Static Approaches to Surgical Correction of Presbyopia. ( 29722364 )
2018
18
Pupil size stability of the cubic phase mask solution for presbyopia. ( 29297211 )
2018
19
Non-lens-based surgical techniques for presbyopia correction. ( 28624312 )
2017
20
Review of Static Approaches to Surgical Correction of Presbyopia. ( 29090052 )
2017
21
Vision improvement in pilots with presbyopia following perceptual learning. ( 29154795 )
2017
22
Ciliary Muscle Electrostimulation to Restore Accommodation in Patients With Early Presbyopia: Preliminary Results. ( 28880331 )
2017
23
Refraction during incipient presbyopia: The Aston Longitudinal Assessment of Presbyopia (ALAP) study. ( 28599911 )
2017
24
Monovision Versus Multifocality for Presbyopia: Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 28674958 )
2017
25
Small incision lenticule extraction (SMILE) monovision for presbyopia correction. ( 29148031 )
2017
26
A Novel Laser Refractive Surgical Treatment for Presbyopia: Optics-Based Customization for Improved Clinical Outcome. ( 28608800 )
2017
27
Correcting presbyopia: the problem of pupil size. ( 28030880 )
2017
28
Corneal Refractive Procedures for the Treatment of Presbyopia. ( 28553423 )
2017
29
Simulation of commercial vs theoretically optimised contact lenses for presbyopia. ( 28439978 )
2017
30
Intracorneal Inlays for the Correction of Presbyopia. ( 28617724 )
2017
31
Awareness of Presbyopia among Rural Female Population in North Karnataka. ( 29207744 )
2017
32
Design of see-through near-eye display for presbyopia. ( 28437967 )
2017
33
Diffractive corneal inlay for presbyopia. ( 28635120 )
2017
34
Bifocal nondiffractive intraocular lens forA enhanced depth of focus in correcting presbyopia: Clinical evaluation. ( 28602323 )
2017
35
The Quest for Spectacle Independence: A Comparison of Multifocal Intraocular Lens Implants and Pseudophakic Monovision for Patients with Presbyopia. ( 27792408 )
2017
36
Virtual Issue Editorial: Presbyopia - grappling with an age-old problem. ( 29044672 )
2017
37
Short-term visual outcome after unilateral implantation of a trifocal diffractive presbyopia-correcting intraocular lens. ( 28889556 )
2017
38
One-Year Clinical Outcomes of a Corneal Inlay for Presbyopia. ( 28445192 )
2017
39
Visual performance after bilateral implantation of 2 new presbyopia-correcting intraocular lenses: Trifocal versus extended range of vision. ( 28732606 )
2017
40
Presbyopia correction after previous refractive laser and cataract surgery: September consultation #1. ( 28991622 )
2017
41
Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy. ( 28754903 )
2017
42
Optimal Keratoplasty for the Correction of Presbyopia and Hypermetropia. ( 28484647 )
2017
43
Monovision by Implantation of Posterior Chamber Phakic Intraocular Lens with a Central Hole (Hole ICL) for Early Presbyopia. ( 28900204 )
2017
44
Monovision LASIK Versus Presbyopia-Correcting IOLs: Comparison of Clinical and Patient-Reported Outcomes. ( 29117414 )
2017
45
A systematic review of pseudophakic monovision for presbyopia correction. ( 28730093 )
2017
46
Contrast Sensitivity in Patients With Emmetropic Presbyopia Before and After Small-Aperture Inlay Implantation. ( 27304602 )
2016
47
Multifocal corneal ablation (Supracor) in hyperopic presbyopia: 1-year results in a cross-sectional study. ( 28009399 )
2016
48
Surgical Correction of Presbyopia: Lenticular, Corneal, and Scleral Approaches. ( 27257729 )
2016
49
Presbyopia and near spectacle correction coverage among public school teachers in Ifo Township, South-West Nigeria. ( 27623724 )
2016
50
Protein Disulfide Levels and Lens Elasticity Modulation: Applications for Presbyopia. ( 27233034 )
2016

Variations for Presbyopia

Expression for Presbyopia

Search GEO for disease gene expression data for Presbyopia.

Pathways for Presbyopia

GO Terms for Presbyopia

Biological processes related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.33 BFSP2 CRYAA MIP
2 lens development in camera-type eye GO:0002088 8.96 CRYGS MIP
3 visual perception GO:0007601 8.8 BFSP2 CRYAA MIP

Molecular functions related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.92 BFSP2 CRYAA CRYGS MIP

Sources for Presbyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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