Aliases & Classifications for Presbyopia

MalaCards integrated aliases for Presbyopia:

Name: Presbyopia 12 76 44 15 63 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11638
ICD10 33 H52.4
ICD9CM 35 367.4
MeSH 44 D011305
SNOMED-CT 68 41256004
UMLS 73 C0033075

Summaries for Presbyopia

PubMed Health : 63 About presbyopia: It happens to all of us eventually: You have to start holding newspapers or books further away in order to be able to read them and clearly recognize letters without straining your eyes.Seeing nearby objects less clearly is a normal part of aging. Known as presbyopia, this typically becomes noticeable in your mid-forties.Although there are no effective treatments for the causes of presbyopia, the effects can be corrected. The best and easiest way to do so is using reading glasses.

MalaCards based summary : Presbyopia is related to cycloplegia and cataract, and has symptoms including aniseikonia An important gene associated with Presbyopia is CRYAA (Crystallin Alpha A). The drugs Dipivefrin and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Wikipedia : 76 Presbyopia is a condition associated with the aging of the eye that results in progressively worsening... more...

Related Diseases for Presbyopia

Diseases related to Presbyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 cycloplegia 31.6 CRYAA CTSC
2 cataract 30.1 BFSP2 CRYAA CRYGS MIP
3 refractive error 11.7
4 myopia 10.5
5 astigmatism 10.4
6 aging 10.2
7 early-onset nuclear cataract 10.0 CRYAA MIP
8 cataract 44 10.0 CRYAA MIP
9 nuclear senile cataract 10.0 CRYAA CRYGS
10 ocular dominance 9.9
11 strabismus 9.9
12 alternating exotropia 9.9
13 exotropia 9.9
14 corneal ectasia 9.9
15 amyloidosis 9.9
16 esotropia 9.9
17 monofixation syndrome 9.9
18 farsightedness 9.9
19 mature cataract 9.8 CRYAA CRYGS MIP
20 lens disease 9.8 CRYAA CRYGS
21 cataract 25 9.7 BFSP2 CRYGS MIP
22 cataract 16, multiple types 9.6 BFSP2 CRYAA CRYGS MIP
23 eye accommodation disease 8.9 BFSP2 CPNE6 CRYAA CRYGS CTSC HIVEP3

Graphical network of the top 20 diseases related to Presbyopia:



Diseases related to Presbyopia

Symptoms & Phenotypes for Presbyopia

UMLS symptoms related to Presbyopia:


aniseikonia

Drugs & Therapeutics for Presbyopia

PubMedHealth treatment related to Presbyopia: 63

Although there are no effective treatments to fight the cause of presbyopia, the effects of presbyopia are easily corrected. The easiest way to solve the problem of not being able to see nearby objects is wearing ready-made reading glasses available in shops. But these readily available reading glasses don't account for possible differences in vision between your eyes or other features, such as astigmatism (an irregularly shaped cornea). Individually adjusted prescription reading glasses are only available from an optician's, where glasses with the required lens power are made especially based on the results of an eye test. The distance between the pupils of your eyes and other factors are also taken into account. Reading glasses are often narrow enough for you to be able to look over them if you want to see things that are further away.If you already wore prescription glasses before presbyopia started becoming an issue, multifocals are an option. Bifocal glasses (bifocals) are one type of multifocal glasses. They have two zones divided in the middle by a visible horizontal line. The lower half of the glasses is for looking at nearby objects, and the upper half is for looking at objects that are further away. Trifocals have a visibly separate third zone for seeing objects at intermediate distances too. In varifocals (also known as progressive lenses), the lines dividing the different zones have been smoothly polished so you can’t see them. They are the most common kind of glasses.

Drugs for Presbyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
2 Antibiotics, Antitubercular Phase 4
3 Alkylating Agents Phase 4
4 Mitomycins Phase 4
5 Nucleic Acid Synthesis Inhibitors Phase 4
6 Anti-Bacterial Agents Phase 4
7 Omega 3 Fatty Acid Phase 4
8 Vitamins Phase 4
9
Tropicamide Approved, Investigational Phase 2 1508-75-4 5593
10 Ophthalmic Solutions Phase 2,Phase 1
11 Pharmaceutical Solutions Phase 2,Phase 1,Not Applicable
12
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
13
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
14
Pilocarpine Approved, Investigational Not Applicable 54-71-7, 92-13-7 5910
15
Hydrogen peroxide Approved, Vet_approved Not Applicable 7722-84-1 784
16
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
17
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
18
Meclocycline Experimental, Investigational Not Applicable 2013-58-3 5480760
19 Neurotransmitter Agents Not Applicable
20 Neurotransmitter Uptake Inhibitors Not Applicable
21 Peripheral Nervous System Agents Not Applicable
22 Adrenergic Agents Not Applicable
23 Dopamine Uptake Inhibitors Not Applicable
24 Sympathomimetics Not Applicable
25 Autonomic Agents Not Applicable
26 Central Nervous System Stimulants Not Applicable
27 Dopamine Agents Not Applicable
28 Cholinergic Agents Not Applicable
29 Muscarinic Agonists Not Applicable
30 Tea Not Applicable
31 Tetrahydrozoline Not Applicable
32 Anti-Infective Agents, Local Not Applicable
33 Anti-Infective Agents Not Applicable
34 Contact Lens Solutions Not Applicable
35 Disinfectants Not Applicable
36 Anesthetics Not Applicable
37 Dermatologic Agents Not Applicable
38 Keratolytic Agents Not Applicable
39 Antifungal Agents Not Applicable
40 Central Nervous System Depressants Not Applicable
41 Polymethyl Methacrylate Not Applicable

Interventional clinical trials:

(show top 50) (show all 153)
# Name Status NCT ID Phase Drugs
1 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
2 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
3 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
4 Presbyopia-Correcting Intraocular Lenses (IOLs) Completed NCT00963560 Phase 4
5 A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs) Completed NCT01166971 Phase 4
6 Clinical Evaluation of Biofinity Multifocal Compared With Air Optix Aqua Multifocal and With PureVision Multifocal Completed NCT01591499 Phase 4
7 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
8 Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses Completed NCT01061281 Phase 4
9 Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL Completed NCT01275118 Phase 4
10 Visual Performance After RESTOR Implantation Completed NCT01065064 Phase 4
11 A Study to Evaluate the Raindrop Near Vision Inlay Under Flap or Within Pocket Recruiting NCT03376412 Phase 4
12 A Prospective Study to Evaluate the Raindrop Near Vision Inlay With Mitomycin C Recruiting NCT03242317 Phase 4 Mitomycin C
13 A Prospective Study to Evaluate the Raindrop Near Vision Inlay in Presbyopic Patients With Treatments to Optimize the Ocular Surface Before Implantation Recruiting NCT03126877 Phase 4 Mitomycin C
14 A Study Raindrop Near Vision Inlay in Presbyopes Implanted in Corneal Pockets Suspended NCT03326869 Phase 4
15 A Prospective Study To Evaluate The Raindrop Near Vision Inlay In Presybopic or Pseudophakic Patients Treated With Mitomycin C Following Femtosecond Flap Creation. Terminated NCT03101501 Phase 4 Mitomycin c
16 LaserACE® Procedure Restore Visual Function and Range of Accommodation LaserACE® Procedure Unknown status NCT01491360 Phase 3
17 A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects Unknown status NCT02668523 Phase 3
18 Evaluation of the FluidVision Accommodating Lens Unknown status NCT02049567 Phase 2, Phase 3
19 Evaluation of the FluidVisionTM AIOL With an Improved Injector Unknown status NCT02418871 Phase 3
20 SUPRACOR for Myopia and Myopic Astigmatism Unknown status NCT01404884 Phase 3
21 Intrastromal Correction of Ametropia by a Femtosecond Laser Unknown status NCT00928122 Phase 3
22 Intrastromal Presbyopia Correction by Means of a Femtosecond Laser Completed NCT01025050 Phase 3
23 Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes Completed NCT00910403 Phase 3
24 Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure Completed NCT01322919 Phase 3
25 Phase 3 Efficacy Study of AGN-190584 in Participants With Presbyopia Recruiting NCT03804268 Phase 3 AGN-190584;Vehicle
26 Investigation of the Presbia Flexivue Microlens™ Active, not recruiting NCT02110472 Phase 3
27 Clinical Evaluation of the Lenstec SBL-3 Multifocal Intraocular Lens Active, not recruiting NCT02487160 Phase 3
28 Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses Terminated NCT00585026 Phase 3
29 A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed NCT03201562 Phase 2 PRX-100;PRX-100 Component #1;PRX-100 Vehicle
30 A Study to Evaluate the Safety and Efficacy of EV06 Ophthalmic Solution in Improving Vision in Subjects With Presbyopia Completed NCT02516306 Phase 1, Phase 2 EV06 Ophthalmic Solution;Placebo Ophthalmic Solution
31 A Safety, Efficacy and Pharmacokinetic Study of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02780115 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-199201 Vehicle;AGN-190584 Vehicle
32 A Study of the Concurrent Use of AGN-190584 and AGN-199201 in Participants With Presbyopia Completed NCT02595528 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-190584 vehicle;AGN-199201 + AGN-190584 Combination;AGN-199201 vehicle
33 Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed NCT02554396 Phase 2 PRX-100;Placebo
34 Safety and Efficacy of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02197806 Phase 2 AGN-199201;AGN-190584;AGN-199201 Vehicle
35 Safety, Tolerability, and Efficacy of PresbiDrops (CSF-1), a Topical Ophthalmic Drug for Presbyopia Completed NCT02745223 Phase 2 PresbiDrops (CSF-1);Placebo
36 Safety, Tolerability and Efficacy of PresbiDrops (CSF-1) in Presbyopic Subjects Completed NCT02965664 Phase 2 PresbiDrops (CSF-1);Placebo
37 A Study of Safety and Efficacy of UNR844 Chloride (UNR844-Cl) Eye Drops in Subjects With Presbyopia. Not yet recruiting NCT03809611 Phase 2 UNR844-Cl;Placebo
38 Presbyopia Compensation: Looking for Electrophysiological Predictors Unknown status NCT02444130
39 Clinical Efficacy of the Pinhole Soft Contact Lenses for Correcting Presbyopia Unknown status NCT02612584 Not Applicable
40 Functional and Physiological Changes Induced by Pinhole Glasses in Presbyopia Unknown status NCT02722291 Not Applicable
41 The Effect of Cataract Extraction on the Contractility of Ciliary Muscle Unknown status NCT00624039 Not Applicable
42 Functional Assessment of Activities of Daily Living (ADL) in Patients Who Underwent Mini-monovision Correction Unknown status NCT02431156
43 Visual and Economic Profits of ReSTOR® Multifocal Intraocular Lenses (IOL) on Public Health Patients in Spain Unknown status NCT01088282 Not Applicable
44 Functional Assessment of ADL in Patients Who Underwent Bifocal and Trifocal Presbyopic Correction Unknown status NCT03021512
45 Clinical Evaluation of a Progressive Addition Lens (PAL) Unknown status NCT01443585 Not Applicable
46 Study to Evaluate the Safety and Efficacy of HI-BRITE Large Diameter Rigid Gas Permeable Contact Lens Unknown status NCT02812316 Not Applicable
47 Mix and Match Study of Two Multifocal Intraocular Lens With Different Add Power Unknown status NCT02556944 Not Applicable
48 Assessment of Near Vision Capacity in Different Light Intensities Unknown status NCT03024073
49 Development of a Validated Chart for Intermediate Vision Assessment Unknown status NCT02279446
50 Study to Evaluate the Clinical Performance of SynergEyes A2 Hybrid Contact Lenses Unknown status NCT01058629 Not Applicable

Search NIH Clinical Center for Presbyopia

Cochrane evidence based reviews: presbyopia

Genetic Tests for Presbyopia

Anatomical Context for Presbyopia

MalaCards organs/tissues related to Presbyopia:

41
Eye, Testes, Cortex

Publications for Presbyopia

Articles related to Presbyopia:

(show top 50) (show all 500)
# Title Authors Year
1
Revisiting monovision for presbyopia. ( 29708928 )
2018
2
Effect of unifocal versus multifocal lenses on cervical spine posture in patients with presbyopia. ( 29616886 )
2018
3
Fundamentals of Presbyopia: visual processing and binocularity in its transformation. ( 29417087 )
2018
4
Extended depth of focus intraocular lenses for presbyopia. ( 29697436 )
2018
5
Commentary: Presbyopia correction with intraocular lenses. ( 29676324 )
2018
6
Outcomes of presbyopia-correcting intraocular lenses after laser in situ keratomileusis. ( 29594789 )
2018
7
Corneal Inlays for Presbyopia Explanted Due to Corneal Haze. ( 29738595 )
2018
8
Through-Focus Vision Performance and Light Disturbances of 3 New Intraocular Lenses for Presbyopia Correction. ( 29651343 )
2018
9
Light disturbance with multifocal contact lens and monovision for presbyopia. ( 29576438 )
2018
10
Global Prevalence of Presbyopia and Vision Impairment from Uncorrected Presbyopia: Systematic Review, Meta-analysis, and Modelling. ( 29753495 )
2018
11
Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE). ( 29382905 )
2018
12
Presbyopia monovision correction and cortical adaptation. ( 29152742 )
2018
13
Simulation of the Effect of Different Presbyopia-Correcting Intraocular Lenses With Eyes With Previous Laser Refractive Surgery. ( 29634836 )
2018
14
Prevalence and incidence of presbyopia in urban Southern China. ( 29367202 )
2018
15
Scleral surgery for the treatment of presbyopia: where are we today? ( 29497624 )
2018
16
Prevalence of refractive error, presbyopia, and unmet need of spectacle coverage in a northern district of Bangladesh: Rapid Assessment of Refractive Error study. ( 28976783 )
2018
17
Erratum: Review of Static Approaches to Surgical Correction of Presbyopia. ( 29722364 )
2018
18
Retrospective observational study of micro-monovision small incision lenticule extraction (SMILE) for the correction of presbyopia and myopia. ( 30544483 )
2018
19
Intentional Undercorrection by Implantation of Posterior Chamber Phakic Intraocular Lens With A Central Hole (Hole ICL) For Early Presbyopia. ( 29984242 )
2018
20
Effect of providing near glasses on productivity among rural Indian tea workers with presbyopia (PROSPER): a randomised trial. ( 30049615 )
2018
21
Presbyopia and the Sustainable Development Goals. ( 30049616 )
2018
22
From Presbyopia to Cataracts: A Critical Review on Dysfunctional Lens Syndrome. ( 30050689 )
2018
23
Presbyopia and Ocular Conditions Causing Near Vision Impairment in Older Adults From the Brazilian Amazon Region. ( 30118685 )
2018
24
Presbyopia and the Sustainable Development Goals. ( 30223980 )
2018
25
Presbyopia: Effectiveness of correction strategies. ( 30244049 )
2018
26
Effects of Display Curvature, Presbyopia, and Task Duration on Visual Fatigue, Task Performance, and User Satisfaction. ( 30281334 )
2018
27
Correction of presbyopia: An integrated update for the practical surgeon. ( 30294526 )
2018
28
Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia. ( 30372745 )
2018
29
Clinical feasibility of pinhole glasses in presbyopia. ( 30460857 )
2018
30
Near Vision Improvement with the Use of a New Topical Compound for Presbyopia Correction: A Prospective, Consecutive Interventional Non-Comparative Clinical Study. ( 30465236 )
2018
31
Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries. ( 30469062 )
2018
32
Impact of Presbyopia and Its Correction in Low- and Middle-Income Countries. ( 30523677 )
2018
33
Pupil size stability of the cubic phase mask solution for presbyopia. ( 29297211 )
2018
34
Non-lens-based surgical techniques for presbyopia correction. ( 28624312 )
2017
35
Review of Static Approaches to Surgical Correction of Presbyopia. ( 29090052 )
2017
36
Vision improvement in pilots with presbyopia following perceptual learning. ( 29154795 )
2017
37
Ciliary Muscle Electrostimulation to Restore Accommodation in Patients With Early Presbyopia: Preliminary Results. ( 28880331 )
2017
38
Refraction during incipient presbyopia: The Aston Longitudinal Assessment of Presbyopia (ALAP) study. ( 28599911 )
2017
39
Monovision Versus Multifocality for Presbyopia: Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 28674958 )
2017
40
Small incision lenticule extraction (SMILE) monovision for presbyopia correction. ( 29148031 )
2017
41
A Novel Laser Refractive Surgical Treatment for Presbyopia: Optics-Based Customization for Improved Clinical Outcome. ( 28608800 )
2017
42
Correcting presbyopia: the problem of pupil size. ( 28030880 )
2017
43
Corneal Refractive Procedures for the Treatment of Presbyopia. ( 28553423 )
2017
44
Simulation of commercial vs theoretically optimised contact lenses for presbyopia. ( 28439978 )
2017
45
Intracorneal Inlays for the Correction of Presbyopia. ( 28617724 )
2017
46
Awareness of Presbyopia among Rural Female Population in North Karnataka. ( 29207744 )
2017
47
Design of see-through near-eye display for presbyopia. ( 28437967 )
2017
48
Diffractive corneal inlay for presbyopia. ( 28635120 )
2017
49
Bifocal nondiffractive intraocular lens forA enhanced depth of focus in correcting presbyopia: Clinical evaluation. ( 28602323 )
2017
50
The Quest for Spectacle Independence: A Comparison of Multifocal Intraocular Lens Implants and Pseudophakic Monovision for Patients with Presbyopia. ( 27792408 )
2017

Variations for Presbyopia

Expression for Presbyopia

Search GEO for disease gene expression data for Presbyopia.

Pathways for Presbyopia

GO Terms for Presbyopia

Biological processes related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.33 BFSP2 CRYAA MIP
2 lens development in camera-type eye GO:0002088 8.96 CRYGS MIP
3 visual perception GO:0007601 8.8 BFSP2 CRYAA MIP

Molecular functions related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.92 BFSP2 CRYAA CRYGS MIP

Sources for Presbyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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