MCID: PRT082
MIFTS: 52

Preterm Premature Rupture of the Membranes

Categories: Genetic diseases, Reproductive diseases

Aliases & Classifications for Preterm Premature Rupture of the Membranes

MalaCards integrated aliases for Preterm Premature Rupture of the Membranes:

Name: Preterm Premature Rupture of the Membranes 57 12
Preterm Premature Rupture of Membranes 29 6 40 73
Preterm Premature Rupture of the Membranes, Susceptibility to 57 13
Pprom 57 12

Characteristics:

HPO:

32
preterm premature rupture of the membranes:
Inheritance polygenic inheritance


Classifications:



External Ids:

OMIM 57 610504
Disease Ontology 12 DOID:0111144
MedGen 42 C0729264
SNOMED-CT via HPO 69 237266003 44223004
UMLS 73 C0729264

Summaries for Preterm Premature Rupture of the Membranes

OMIM : 57 Preterm premature rupture of the membranes is defined as rupture of membranes before 37 weeks of gestation, which occurs in approximately 3% of all pregnancies and accounts for about one-third of spontaneous preterm births (ACOG Practice Bulletin, 1998). Srinivas and Macones (2005) reviewed the pathophysiology of PPROM and noted that familial clustering and ethnic differences in the incidence of PPROM suggest possible genetic influences. (610504)

MalaCards based summary : Preterm Premature Rupture of the Membranes, also known as preterm premature rupture of membranes, is related to chorioamnionitis and placenta disease. An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (Serpin Family H Member 1), and among its related pathways/superpathways are Innate Immune System and Pathways in cancer. The drugs Ampicillin and Cefuroxime have been mentioned in the context of this disorder. Affiliated tissues include testes, cervix and thymus, and related phenotypes are premature rupture of membranes and endocrine/exocrine gland

Disease Ontology : 12 A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation.

Related Diseases for Preterm Premature Rupture of the Membranes

Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 chorioamnionitis 30.9 CXCL8 IL6 MMP8
2 placenta disease 30.6 CXCL8 IL6 SERPINH1
3 vaginitis 30.3 CXCL8 IL6 SERPINH1
4 tendinopathy 10.7 MMP1 MMP8
5 periapical periodontitis 10.7 IL6 MMP8
6 recurrent corneal erosion 10.7 CXCL8 IL6
7 bagassosis 10.7 CXCL8 IL6
8 acute transverse myelitis 10.7 CXCL8 IL6
9 streptococcal toxic-shock syndrome 10.7 CXCL8 IL6
10 periodontitis, aggressive, 1 10.7 MMP1 MMP8
11 denture stomatitis 10.7 CXCL8 IL6
12 papillary conjunctivitis 10.7 CXCL8 IL6
13 acute monoblastic leukemia 10.6 CXCL8 IL6
14 capillary leak syndrome 10.6 CXCL8 IL6
15 conjunctivochalasis 10.6 MMP1 TIMP2
16 meconium aspiration syndrome 10.6 CXCL8 IL6
17 adenomyosis 10.6 MMP1 TIMP2
18 periapical granuloma 10.6 CXCL8 MMP8
19 lipodermatosclerosis 10.6 MMP1 TIMP2
20 louse-borne relapsing fever 10.6 CXCL8 IL6
21 castleman disease 10.6 IL6 IL6R
22 transverse myelitis 10.6 CXCL8 IL6
23 necrotizing fasciitis 10.5 CXCL8 IL6
24 cervical incompetence 10.5 IL6 SERPINH1
25 bacteriuria 10.5 CXCL8 IL6
26 periodontitis, chronic 10.5 IL6 MMP1 MMP8
27 radiculopathy 10.5 CXCL8 IL6
28 gingival disease 10.4 IL6 MMP1 MMP8
29 rosacea 10.4 IL6 MMP8
30 cowpox 10.4 CXCL8 IL6
31 fibromatosis, gingival, 1 10.4 MMP1 SERPINH1
32 opisthorchiasis 10.4 CXCL8 IL6R
33 cecal disease 10.4 IL6 PGRMC1
34 acute cystitis 10.4 CXCL8 IL6
35 nodular malignant melanoma 10.4 MMP1 TIMP2
36 appendicitis 10.4 CXCL8 IL6 MMP8
37 aggressive periodontitis 10.4 CXCL8 IL6 MMP8
38 pulpitis 10.4 CXCL8 IL6 MMP1
39 bronchiolitis obliterans 10.4 CXCL8 IL6 MMP8
40 inguinal hernia 10.4 IL6 MMP1 TIMP2
41 bacterial meningitis 10.4 CXCL8 IL6 MMP8
42 gingivitis 10.4 CXCL8 IL6 MMP8
43 encephalomalacia 10.3 IL6 SERPINH1
44 pulmonary emphysema 10.3 MMP1 MMP8 TIMP2
45 viral meningitis 10.3 CXCL8 IL6 TIMP2
46 bone inflammation disease 10.3 CXCL8 IL6 MMP1
47 synovitis 10.3 CXCL8 IL6 MMP1
48 cytomegalovirus infection 10.3 CXCL8 IL6
49 lung giant cell carcinoma 10.3 CXCL8 IL6R
50 cervicitis 10.3

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to Preterm Premature Rupture of the Membranes

Symptoms & Phenotypes for Preterm Premature Rupture of the Membranes

Clinical features from OMIM:

610504

Human phenotypes related to Preterm Premature Rupture of the Membranes:

32
# Description HPO Frequency HPO Source Accession
1 premature rupture of membranes 32 HP:0001788

MGI Mouse Phenotypes related to Preterm Premature Rupture of the Membranes:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 IL6 IL6R IL6ST INHA INHBA PGRMC1
2 homeostasis/metabolism MP:0005376 9.61 IL6 IL6R IL6ST INHA INHBA MMP1
3 neoplasm MP:0002006 9.1 MMP1 MMP8 IL6 IL6R IL6ST INHA

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

Drugs for Preterm Premature Rupture of the Membranes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ampicillin Approved, Vet_approved Phase 4,Phase 3 69-53-4 6249
2
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
3 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
4 Antibiotics, Antitubercular Phase 4,Phase 3,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
6 Antitubercular Agents Phase 4,Phase 3,Not Applicable
7 Vaccines Phase 4,Phase 2
8 cefuroxime axetil Phase 4
9
Cefazolin Approved Phase 3 25953-19-9 656510 33255
10
Clarithromycin Approved Phase 3 81103-11-9 84029
11
Erythromycin Approved, Investigational, Vet_approved Phase 3,Not Applicable 114-07-8 12560
12
Azithromycin Approved Phase 3 83905-01-5 55185 447043
13
Betamethasone Approved, Vet_approved Phase 2, Phase 3 378-44-9 9782
14
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
15
Vitamin C Approved, Nutraceutical Phase 3,Phase 2 50-81-7 5785 54670067
16
Tocopherol Approved, Investigational, Nutraceutical Phase 3 1406-66-2 14986
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
18 Cytochrome P-450 CYP3A Inhibitors Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 Gastrointestinal Agents Phase 3,Not Applicable
21 Antioxidants Phase 3,Phase 1,Phase 2
22 Micronutrients Phase 3,Phase 2,Early Phase 1
23 Protective Agents Phase 3,Phase 1,Phase 2,Early Phase 1
24 Trace Elements Phase 3,Phase 2,Early Phase 1
25 Vitamins Phase 3,Phase 2,Early Phase 1
26 Anti-Inflammatory Agents Phase 2, Phase 3
27 Hormone Antagonists Phase 2, Phase 3,Not Applicable
28 Hormones Phase 2, Phase 3,Not Applicable
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Not Applicable
30 Erythromycin Estolate Phase 3,Not Applicable
31 Erythromycin Ethylsuccinate Phase 3,Not Applicable
32 Erythromycin stearate Phase 3,Not Applicable
33 Tocopherols Phase 3
34 Tocotrienols Phase 3
35 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3,Phase 1
36 Respiratory System Agents Phase 2, Phase 3,Phase 1
37 Anti-Asthmatic Agents Phase 2, Phase 3
38 Betamethasone benzoate Phase 2, Phase 3
39 Betamethasone sodium phosphate Phase 2, Phase 3
40 Betamethasone Valerate Phase 2, Phase 3 2152-44-5
41 Betamethasone-17,21-dipropionate Phase 2, Phase 3
42 glucocorticoids Phase 2, Phase 3
43 Omega 3 Fatty Acid Nutraceutical Phase 3
44 Tocotrienol Investigational, Nutraceutical Phase 3 6829-55-6
45
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
46
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
47
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
48 Analgesics Phase 2,Not Applicable
49 Analgesics, Non-Narcotic Phase 2
50 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women Completed NCT02377349 Phase 4 Saline placebo
2 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Recruiting NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
3 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
4 Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane Unknown status NCT01503606 Phase 3 Cefazolin;Clarithromycin;Cefazolin;Clarithromycin
5 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
6 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
7 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
8 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3 vitamine C and E
9 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Completed NCT02716909 Phase 3
10 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
11 Treatment of ppROM With Erythromycin vs. Azithromycin Trial Recruiting NCT03060473 Phase 3 Azithromycin;Erythromycin;Ampicillin;Amoxicillin
12 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
13 Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes Withdrawn NCT01556334 Phase 3 Azithromycin;Erythromycin
14 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
15 Early FETO for Severe Congenital Diaphragmatic Hernia Unknown status NCT01731509 Phase 2
16 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
17 L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia Terminated NCT00469846 Phase 2
18 A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the GlaxoSmithKline (GSK) Biologicals' Respiratory Syncytial Virus (RSV) Investigational Vaccine (GSK3003891A) in Healthy Pregnant Women and Infants Born to Vaccinated Mothers Withdrawn NCT03191383 Phase 2 Placebo (Formulation buffer S9b)
19 Fetoscopic Meningomyelocele Repair Study Recruiting NCT02230072 Phase 1
20 Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes Unknown status NCT01584323 Not Applicable
21 The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes Unknown status NCT02635451
22 A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT02327637 Not Applicable
23 Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes Unknown status NCT02069587 Not Applicable
24 The Use of Cranberries in Women With Preterm Premature Rupture of Membranes Unknown status NCT00247104 Not Applicable Cranberries - Vaccinium macrocarpon
25 Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management Unknown status NCT02548013 Not Applicable
26 Evaluation of the Role of Plasma Procalcitonin in Prediction of Intra-amniotic Infection in Preterm Premature Rupture of Membrane Unknown status NCT02104791 procalcitonin
27 Development of Pharmacokinetics Model in Pregnancy Women and Fetus Unknown status NCT01916330
28 Cervical Ripening in Premature Rupture of Membranes Unknown status NCT02314728 Not Applicable Misoprostol;Oxytocin
29 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624 Not Applicable
30 Multi-resistant Enterobacteriaceae Colonisation in Less Than 32 Weeks Pregnant Women Admitted to the Hospital. Unknown status NCT02631226
31 Letrozole Versus Chinese Herbal Medicine on Polycystic Ovary Syndrome (PCOS) Unknown status NCT01431352 Not Applicable Letrozole;Chinese herbal medicine granules or Chinese herbal medicine granules placebo
32 PPROM Erythromycin Versus Azithromycin Completed NCT01431248
33 Preterm Premature Rupture of Membranes (PPROM): Bed Rest Versus Activity Trial Completed NCT01544387 Not Applicable
34 The Value of Amniopatch in Preterm Premature Rupture of Membranes Completed NCT03473210 Not Applicable Antibiotics;Corticosteroid
35 Fetal and Maternal Outcome in Preterm Premature Rupture of Membranes (PPROM) Completed NCT03491826
36 Transperineal Ultrasonography and Premature Rupture of Membranes Completed NCT02386644 Not Applicable
37 Monitoring of the Inflammatory Response of Patients With Premature Rupture of Membranes With Bedside Tests Completed NCT00940043
38 Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes Completed NCT01975792
39 Repeat Antenatal Corticosteroids Completed NCT03133104
40 Biomarkers of Intra-amniotic Infection in Women With Preterm Premature Ruptured Amniotic Membranes Completed NCT00701350
41 The Biomarker Study Completed NCT01148654
42 Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes Completed NCT00342667
43 Intrauterine Cleaning After Placental Delivery at Cesarean Section: RCT Completed NCT02152735 Not Applicable
44 A Post-marketing, Observational, Retrospective Study to Assess the Safety of RefortrixTM (Tdap) When Administered During Pregnancy in a Maternal Immunization Program in Brazil. Completed NCT02757950
45 Protein and Ultrasound Indicators of Preterm Birth Completed NCT01412931
46 Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Completed NCT01322529
47 FOLCROM Trial: Foley Catheter in Rupture of Membranes Completed NCT01973036 Not Applicable Oxytocin
48 PPROM Registry (Preterm Premature Rupture of Membranes) Recruiting NCT02997345
49 Myometrial Thickness as a Predictor for the Latency Interval in PPROM Recruiting NCT02380560
50 Early Detection of Chorioamnionitis in Preterm Premature Rupture of Membranes Recruiting NCT02901795

Search NIH Clinical Center for Preterm Premature Rupture of the Membranes

Genetic Tests for Preterm Premature Rupture of the Membranes

Genetic tests related to Preterm Premature Rupture of the Membranes:

# Genetic test Affiliating Genes
1 Preterm Premature Rupture of Membranes 29 SERPINH1

Anatomical Context for Preterm Premature Rupture of the Membranes

MalaCards organs/tissues related to Preterm Premature Rupture of the Membranes:

41
Testes, Cervix, Thymus, Placenta, Bone, Ovary, Liver

Publications for Preterm Premature Rupture of the Membranes

Articles related to Preterm Premature Rupture of the Membranes:

(show top 50) (show all 296)
# Title Authors Year
1
Annual Report of the Perinatology Committee, Japan Society of Obstetrics and Gynecology, 2016: Overall report on a comprehensive retrospective study of obstetric management of preterm labor and preterm premature rupture of the membranes. ( 29114962 )
2018
2
Concurrent intraoperative uterine rupture and placenta accreta. Do preoperative chronic hypertension, preterm premature rupture of membranes, chorioamnionitis, and placental abruption provide warning to this rare occurrence? ( 29756067 )
2018
3
Contribution of Amniotic Fluid along Gestation to the Prediction of Perinatal Mortality in Women with Early Preterm Premature Rupture of Membranes. ( 28535541 )
2018
4
Genital tract GBS and rate of histologic chorioamnionitis in patients with preterm premature rupture of membrane. ( 28715920 )
2017
5
Frequency and clinical significance of short cervix in patients with preterm premature rupture of membranes. ( 28358839 )
2017
6
No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes. ( 28859768 )
2017
7
Impact of Latency Duration on the Prognosis of Preterm Infants after Preterm Premature Rupture of Membranes at 24 to 32 Weeks' Gestation: A National Population-Based Cohort Study. ( 28081890 )
2017
8
Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations. ( 28873067 )
2017
9
Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. ( 28936902 )
2017
10
Chorioamnionitis following preterm premature rupture of membranes and fetal heart rate variability. ( 28945767 )
2017
11
Cord Prolapse After Preterm Premature Rupture of the Membranes. ( 29066017 )
2017
12
Amniopatch treatment of iatrogenic preterm premature rupture of membranes (iPPROM) after fetoscopic laser surgery for twin-twin transfusion syndrome. ( 27686840 )
2017
13
Transvaginal sonographic assessment of cervix in prediction of admission to delivery interval in preterm premature rupture of membranes. ( 28693352 )
2017
14
Maternal c-reactive protein and oxidative stress markers as predictors of delivery latency in patients experiencing preterm premature rupture of membranes. ( 28099729 )
2017
15
Perinatal outcomes after previable preterm premature rupture of membranes before 24 weeks of gestation. ( 28822226 )
2017
16
Treatment of Preterm Premature Rupture of Membranes with Oligo-/Anhydramnion Colonized by Multiresistant Bacteria with Continuous Amnioinfusion and Antibiotic Administrations through a Subcutaneously Implanted Intrauterine Port System: A Case Report. ( 26447923 )
2017
17
Prolonged latency of preterm premature rupture of membranes and risk of neonatal sepsis. ( 26723194 )
2016
18
Contribution of Histologic Chorioamnionitis and Fetal Inflammatory Response Syndrome to Increased Risk of Brain Injury in Infants With Preterm Premature Rupture of Membranes. ( 27353694 )
2016
19
Maternal serum interleukin-6 in the management of patients with preterm premature rupture of membranes. ( 26669630 )
2016
20
High Diversity and Variability in the Vaginal Microbiome in Women following Preterm Premature Rupture of Membranes (PPROM): A Prospective Cohort Study. ( 27861554 )
2016
21
Preterm premature rupture of membrane assessment via transperineal ultrasonography: a diagnostic accuracy study. ( 26755245 )
2016
22
ADAMTS4 and Oxidative/Antioxidative Status in Preterm Premature Rupture of Membranes. ( 27182768 )
2016
23
Non-Invasive Prediction of Histologic Chorioamnionitis in Women with Preterm Premature Rupture of Membranes. ( 26847301 )
2016
24
Diagnostic and Prognostic Value of Presepsin for Subclinical Chorioamnionitis in Pregnancies between 23-28 Week with Preterm Premature Rupture of the Membranes. ( 27994922 )
2016
25
Accuracy of several maternal seric markers for predicting histological chorioamnionitis after preterm premature rupture of membranes: a prospective and multicentric study. ( 27591714 )
2016
26
Soluble HLA-G concentrations in maternal blood and cervical vaginal fluid of pregnant women with preterm premature rupture of membranes. ( 27232355 )
2016
27
Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes. ( 26690900 )
2016
28
Neonatal and maternal outcomes following midtrimester preterm premature rupture of the membranes: a retrospective cohort study. ( 26831896 )
2016
29
Perinatal Outcomes in Cephalic Compared With Noncephalic Singleton Presentation in the Setting of Preterm Premature Rupture of Membranes Before 32 Weeks of Gestation. ( 27607865 )
2016
30
Preterm labor and preterm premature rupture of membranes have a different pattern in the involved compartments of acute histologoic chorioamnionitis and/or funisitis: Patho-physiologic implication related to different clinical manifestations. ( 27090052 )
2016
31
Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes. ( 26812854 )
2016
32
Predictive factors for latency period in viable pregnancies complicated by preterm premature rupture of the membranes. ( 28913037 )
2015
33
Clinical application of immunomagnetic reduction for quantitative measurement of insulin-like growth factor binding protein-1 in the prediction of pregnant women with preterm premature rupture of membranes. ( 25281931 )
2015
34
Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. ( 25223243 )
2015
35
Pilot Randomized Controlled Trial to Evaluate the Impact of Bed Rest on Maternal and Fetal Outcomes in Women with Preterm Premature Rupture of the Membranes. ( 26461925 )
2015
36
Herpes Simplex Virus Cervicitis Mimicking Preterm Premature Rupture of Membranes. ( 25923023 )
2015
37
[A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes]. ( 26412166 )
2015
38
Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: A systematic review of the literature. ( 26004735 )
2015
39
Pentraxin 3 concentrations of the mothers with preterm premature rupture of membranes and their neonates, and early neonatal outcome. ( 25048752 )
2015
40
Procalcitonin for prediction of chorioamnionitis in preterm premature rupture of membranes. ( 26333937 )
2015
41
Retention of cervical cerclage after preterm premature rupture of the membranes: a critical appraisal. ( 25416200 )
2015
42
Related factors and adverse neonatal outcomes in women with preterm premature rupture of membranes complicated by histologic chorioamnionitis. ( 25644559 )
2015
43
Short-Term and Long-Term Postnatal Outcomes of Expectant Management After Previable Preterm Premature Rupture of Membranes With and Without Persistent Oligohydramnios. ( 26444125 )
2015
44
Is Preterm Premature Rupture of Membranes Latency Influenced by Single Versus Multiple Agent Antibiotic Prophylaxis in Group B Streptococcus Positive Women Delivering Preterm? ( 26605446 )
2015
45
Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. ( 25884766 )
2015
46
Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review. ( 25787907 )
2015
47
Tocolytics for preterm premature rupture of membranes. ( 24578236 )
2014
48
Serial ultrasonographic examination of the fetal thymus in the prediction of early neonatal sepsis in preterm premature rupture of membranes. ( 25226869 )
2014
49
Usefulness of maternal serum C-reactive protein with vaginal Ureaplasma urealyticum as a marker for prediction of imminent preterm delivery and chorioamnionitis in patients with preterm labor or preterm premature rupture of membranes. ( 25503859 )
2014
50
Reply-Vaginal Sampling of Amniotic Fluid in Preterm Premature Rupture of Membranes: A New Technique for Early Detection of Subclinical Chorioamnionitis? ( 25108603 )
2014

Variations for Preterm Premature Rupture of the Membranes

ClinVar genetic disease variations for Preterm Premature Rupture of the Membranes:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SERPINH1 SERPINH1, -656C-T single nucleotide variant Pathogenic
2 MMP8 MMP8, HAPLOTYPE, TGG single nucleotide variant Pathogenic
3 MMP1 NM_002421.3(MMP1): c.-1673G= single nucleotide variant Pathogenic,risk factor GRCh37 Chromosome 11, 102670496: 102670496
4 MMP1 NM_002421.3(MMP1): c.-1673G= single nucleotide variant Pathogenic,risk factor GRCh38 Chromosome 11, 102799765: 102799765

Expression for Preterm Premature Rupture of the Membranes

Search GEO for disease gene expression data for Preterm Premature Rupture of the Membranes.

Pathways for Preterm Premature Rupture of the Membranes

Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CXCL8 IL6 IL6R IL6ST MMP1 MMP8
2 12.6 CXCL8 IL6 IL6R IL6ST MMP1
3
Show member pathways
12.57 MMP1 MMP8 SERPINH1 TIMP2
4
Show member pathways
12.44 CXCL8 IL6 IL6R IL6ST
5
Show member pathways
12.08 IL6 IL6R IL6ST
6 12.02 IL6 IL6R MMP1
7 12.01 CXCL8 IL6 IL6R
8
Show member pathways
11.94 IL6 IL6R IL6ST
9
Show member pathways
11.89 CXCL8 IL6 IL6R TIMP2
10
Show member pathways
11.89 CXCL8 IL6 IL6R IL6ST MMP1
11
Show member pathways
11.74 MMP1 MMP8 TIMP2
12 11.73 IL6 IL6R IL6ST
13 11.69 CXCL8 IL6 MMP1
14 11.68 CXCL8 IL6 IL6R MMP1
15
Show member pathways
11.65 IL6 IL6R IL6ST
16 11.61 CXCL8 IL6 MMP1
17
Show member pathways
11.53 CXCL8 IL6 IL6R IL6ST
18
Show member pathways
11.49 CXCL8 IL6 MMP1
19 11.46 CXCL8 MMP1 TIMP2
20 11.31 IL6 IL6R INHBA
21
Show member pathways
11.23 IL6 IL6R IL6ST
22 11.11 CXCL8 IL6 MMP1
23 11.06 IL6 IL6R IL6ST
24 11.05 CXCL8 IL6 IL6R IL6ST INHBA
25 10.96 CXCL8 IL6 IL6R MMP1
26 10.87 IL6ST MMP1
27 10.86 CXCL8 IL6

GO Terms for Preterm Premature Rupture of the Membranes

Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 CXCL8 IL6 INHA INHBA MMP8 SERPINH1
2 neuronal cell body GO:0043025 9.67 IL6ST INHA PGRMC1 TIMP2
3 extracellular region GO:0005576 9.65 CXCL8 IL6 IL6R IL6ST INHA INHBA
4 ciliary neurotrophic factor receptor complex GO:0070110 9.26 IL6R IL6ST
5 inhibin A complex GO:0043512 9.16 INHA INHBA
6 interleukin-6 receptor complex GO:0005896 8.8 IL6 IL6R IL6ST

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.89 CXCL8 IL6 INHBA TIMP2
2 regulation of signaling receptor activity GO:0010469 9.77 CXCL8 IL6 INHA INHBA RLN1
3 cell cycle arrest GO:0007050 9.76 CXCL8 INHA INHBA
4 extracellular matrix disassembly GO:0022617 9.73 MMP1 MMP8 TIMP2
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 IL6 IL6R IL6ST
6 response to cytokine GO:0034097 9.69 IL6R IL6ST TIMP2
7 positive regulation of osteoblast differentiation GO:0045669 9.67 IL6 IL6R IL6ST
8 endodermal cell differentiation GO:0035987 9.61 INHBA MMP8
9 endocrine pancreas development GO:0031018 9.61 IL6 IL6R
10 positive regulation of chemokine production GO:0032722 9.6 IL6 IL6R
11 negative regulation of phosphorylation GO:0042326 9.58 INHA INHBA
12 positive regulation of acute inflammatory response GO:0002675 9.57 IL6 IL6ST
13 negative regulation of macrophage differentiation GO:0045650 9.55 INHA INHBA
14 cytokine-mediated signaling pathway GO:0019221 9.55 CXCL8 IL6 IL6R IL6ST MMP1
15 positive regulation of follicle-stimulating hormone secretion GO:0046881 9.52 INHA INHBA
16 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.48 IL6R IL6ST
17 hemoglobin biosynthetic process GO:0042541 9.46 INHA INHBA
18 negative regulation of interferon-gamma biosynthetic process GO:0045077 9.43 INHA INHBA
19 negative regulation of B cell differentiation GO:0045578 9.4 INHA INHBA
20 negative regulation of follicle-stimulating hormone secretion GO:0046882 9.32 INHA INHBA
21 hepatic immune response GO:0002384 9.26 IL6 IL6R
22 positive regulation of leukocyte chemotaxis GO:0002690 9.13 CXCL8 IL6 IL6R
23 interleukin-6-mediated signaling pathway GO:0070102 8.8 IL6 IL6R IL6ST

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 CXCL8 IL6 INHA INHBA
2 growth factor activity GO:0008083 9.61 IL6 INHA INHBA
3 hormone activity GO:0005179 9.58 INHA INHBA RLN1
4 inhibin binding GO:0034711 9.37 INHA INHBA
5 ciliary neurotrophic factor receptor activity GO:0004897 9.26 IL6R IL6ST
6 interleukin-6 receptor activity GO:0004915 9.16 IL6R IL6ST
7 interleukin-6 binding GO:0019981 8.96 IL6R IL6ST
8 interleukin-6 receptor binding GO:0005138 8.8 IL6 IL6R IL6ST

Sources for Preterm Premature Rupture of the Membranes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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