MCID: PRP007
MIFTS: 49

Priapism

Categories: Rare diseases, Reproductive diseases, Cardiovascular diseases, Genetic diseases

Aliases & Classifications for Priapism

MalaCards integrated aliases for Priapism:

Name: Priapism 12 53 55 44 15 73
Priapism, Familial Idiopathic 53 73
Familial Idiopathic Priapism 53
Mentulagra 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9286
ICD10 33 N48.3 N48.30
ICD9CM 35 607.3
MeSH 44 D011317
NCIt 50 C85022

Summaries for Priapism

Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to vasculogenic impotence and impotence, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Apoptosis Pathway. The drugs Prazosin and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 76 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 vasculogenic impotence 30.1 NOS3 PDE5A
2 impotence 29.9 NOS3 PDE5A
3 thrombophilia due to thrombin defect 29.8 F13A1 F5
4 intracranial hypertension 29.4 AQP1 F5
5 homocysteinemia 29.3 F5 NOS3
6 autosomal dominant polycystic kidney disease 29.0 AQP1 KL NOS3
7 low-flow priapism 12.2
8 priapism, familial idiopathic 11.9
9 persistent genital arousal disorder 11.3
10 sexual disorder 10.4 NOS3 PDE5A
11 persistent fetal circulation syndrome 10.4 NOS3 PDE5A
12 carotid artery occlusion 10.4 F5 NOS3
13 sickle cell disease 10.4
14 factor xiii deficiency 10.4 F13A1 F5
15 stuttering 10.3
16 dysfibrinogenemia 10.3 F13A1 F5
17 arteritic anterior ischemic optic neuropathy 10.2 F5 NOS3 PDE5A
18 ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
19 sickle cell anemia 10.1
20 nonarteritic anterior ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
21 leukemia 10.1
22 prostatitis 10.1
23 myeloid leukemia 10.0
24 varicocele 10.0 GNRH1 NOS3
25 ovarian hyperstimulation syndrome 10.0 F5 GNRH1
26 prostate cancer 10.0
27 schizophrenia 10.0
28 spinal cord injury 10.0
29 thrombosis 10.0
30 adenocarcinoma 10.0
31 acquired angioedema 9.9 F5 HP
32 thalassemia 9.9
33 intracranial vasospasm 9.9 HP NOS3
34 purpura 9.9
35 fabry disease 9.8
36 aging 9.8
37 suppression of tumorigenicity 12 9.8
38 protein c deficiency 9.8
39 systemic lupus erythematosus 9.7
40 autism 9.7
41 myeloma, multiple 9.7
42 anxiety 9.7
43 beta-thalassemia 9.7
44 lymphoma 9.7
45 protein s deficiency 9.7
46 hemoglobinopathy 9.7
47 substance abuse 9.7
48 paraphimosis 9.7
49 cocaine abuse 9.7
50 peritonitis 9.7

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

MGI Mouse Phenotypes related to Priapism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 TGFBR3 AQP1 F13A1 F5 HP ITGAV
2 hematopoietic system MP:0005397 9.97 AQP1 F13A1 GNRH1 HP ITGAV KL
3 homeostasis/metabolism MP:0005376 9.92 AQP1 F13A1 F5 GNRH1 HP ITGAV
4 endocrine/exocrine gland MP:0005379 9.88 AQP1 F13A1 GNRH1 ITGAV KL NOS3
5 mortality/aging MP:0010768 9.76 AQP1 F13A1 F5 HP ITGAV KL
6 liver/biliary system MP:0005370 9.73 F5 GNRH1 HP KL NOS3 TGFBR3
7 renal/urinary system MP:0005367 9.43 AQP1 GNRH1 HP ITGAV KL NOS3
8 reproductive system MP:0005389 9.1 AQP1 F13A1 GNRH1 KL NOS3 TGFBR3

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
3 Respiratory System Agents Phase 3
4 Adrenergic Agents Phase 3
5 Adrenergic alpha-1 Receptor Antagonists Phase 3
6 Adrenergic alpha-Antagonists Phase 3
7 Adrenergic Antagonists Phase 3
8 Neurotransmitter Agents Phase 3
9 N-monoacetylcystine Phase 3
10 Antihypertensive Agents Phase 3
11 Expectorants Phase 3
12 Antidotes Phase 3
13 Anti-Infective Agents Phase 3,Phase 1,Phase 2
14 Antioxidants Phase 3
15 Protective Agents Phase 3
16 Antiviral Agents Phase 3,Phase 1
17
Hydroxyurea Approved Phase 2,Phase 1 127-07-1 3657
18
alemtuzumab Approved, Investigational Phase 1, Phase 2,Phase 2 216503-57-0
19
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Phase 2 22916-47-8 4189
20
Everolimus Approved Phase 1, Phase 2,Phase 2 159351-69-6 6442177
21
Sirolimus Approved, Investigational Phase 1, Phase 2,Phase 2 53123-88-9 5284616 6436030 46835353
22
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
23
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
24 Sildenafil Citrate Phase 2 171599-83-0
25 Nucleic Acid Synthesis Inhibitors Phase 2
26 Vasodilator Agents Phase 2
27 Antibodies Phase 2
28 Immunoglobulins Phase 2
29 Phosphodiesterase 5 Inhibitors Phase 2
30 Phosphodiesterase Inhibitors Phase 2
31 Antibodies, Monoclonal Phase 2
32 Anti-Bacterial Agents Phase 1, Phase 2,Phase 2
33 Antibiotics, Antitubercular Phase 1, Phase 2,Phase 2
34 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
35 Antifungal Agents Phase 1, Phase 2,Phase 2
36 Trichostatin A Phase 2
37 Alkylating Agents Phase 2
38 Antirheumatic Agents Phase 2
39 Antineoplastic Agents, Alkylating Phase 2
40 Analgesics Phase 2
41 Citrate Nutraceutical Phase 2
42
Busulfan Approved, Investigational Phase 1 55-98-1 2478
43 Anti-HIV Agents Phase 1
44 JM 3100 Phase 1
45 Anti-Retroviral Agents Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
2 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
3 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy Withdrawn NCT01560091 Phase 3 silodosin;Tamsulosin
4 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
5 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
6 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
7 Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) Recruiting NCT01499888 Phase 1, Phase 2 Alemtuzumab;Sirolimus
8 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
9 SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCD Active, not recruiting NCT02013375 Phase 2 Alemtuzumab;Cyclophosphamide;Sirolimus
10 Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients Not yet recruiting NCT03474965 Phase 2 Crizanlizumab
11 Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease Terminated NCT01987908 Phase 2 Aes-103
12 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
13 Sildenafil for Prevention of Cerebral Vasospasm Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
14 A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in Severe Sickle Cell Disease Recruiting NCT02140554 Phase 1
15 Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence Completed NCT00300235
16 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Recruiting NCT02539771 Not Applicable
17 Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE Recruiting NCT03352986
18 Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose Recruiting NCT03114137
19 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

MalaCards organs/tissues related to Priapism:

41
Myeloid, Prostate, Spinal Cord, Bone Marrow, Heart, Bone, Smooth Muscle

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 742)
# Title Authors Year
1
Superselective Transcatheter Artery Embolization in Patients with Non-ischemic Priapism. ( 29417263 )
2018
2
Molecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability. ( 29394072 )
2018
3
Priapism caused by "Rhino 7 Platinum 3000" an over-the-counter male enhancement supplement. ( 29915255 )
2018
4
Daily tadalafil for the chronic phase of stuttering priapism: a case report. ( 29855284 )
2018
5
Priapism in sickle cell disease: Beware of neuroleptics. ( 29885077 )
2018
6
Comment on "Olanzapine-induced Priapism in a Child with Asperger's Syndrome". ( 29666039 )
2018
7
Prevalence and Characteristics of Priapism in Sickle Cell Disease. ( 29745276 )
2018
8
Through Clinical Observation: The History of Priapism After Spinal Cord Injuries. ( 29054772 )
2018
9
BAUS Consensus Document for the Management of Male Genital Emergencies - Priapism. ( 29357203 )
2018
10
Penoscrotal Decompression-Promising New Treatment Paradigm for Refractory Ischemic Priapism. ( 29550463 )
2018
11
Priapism as the initial sign in hematologic disease: Case report and literature review. ( 29414500 )
2018
12
Successful Management of Psychotropics Induced Stuttering Priapism with Pseudoephedrine in a Patient with Schizophrenia. ( 29713098 )
2018
13
Clitoral priapism due to distant clitoral metastasis of high-grade serous ovarian carcinoma: A case report and review of the literature. ( 29915806 )
2018
14
Case - Temporary chemical castration in the management of recurrent priapism. ( 29405906 )
2018
15
High-flow priapism and urinary retention. ( 29888190 )
2018
16
Priapism and hemodialysis: Case report and literature reviewa8c. ( 29578404 )
2018
17
Recent advances in the management of priapism. ( 29375820 )
2018
18
Prognosis of men with penile metastasis and malignant priapism: a systematic review. ( 29416825 )
2018
19
History of posttraumatic stress disorder A^ priapism A^ Dx? ( 29879245 )
2018
20
Spontaneous detumescence and full restoration of erection in a patient with high-flow priapism with persistent arterial-lacunar fistula after repeated selective embolisation-A case report. ( 29687468 )
2018
21
Poorly Controlled Homocystinuria: A Rare Cause of Ischemic Priapism? ( 29463473 )
2018
22
Commentary to "Ischemic priapism in pediatric patients: spontaneous detumescence with ketamine sedation". ( 29807704 )
2018
23
Ischemic priapism in pediatric patients: Spontaneous detumescence with ketamine sedation. ( 29936034 )
2018
24
Malignant priapism in metastatic prostate cancer: A late event occurring early. ( 29888172 )
2018
25
Penile Metastasis from Prostate Cancer Presenting as Malignant Priapism Detected Using Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography. ( 29430118 )
2018
26
Posttraumatic High-Flow Nonischemic Priapism. ( 29601467 )
2018
27
Role of Penile Prosthesis in Priapism: A Review. ( 29299902 )
2018
28
A new cause of ischaemic priapism: Synthetic cannabinoids. ( 29607523 )
2018
29
The Risks of Using Herbal Supplements for Sexual Dysfunction Associated With Psychotropic Medications: A Case Report of ExtenZe Use and Priapism. ( 29553994 )
2018
30
Priapism Throughout the Ages. ( 29729364 )
2018
31
The Hemodynamic Effects of Intracavernosal Phenylephrine for the Treatment of Ischemic Priapism. ( 29960632 )
2018
32
Emergency department management of priapism [digest]. ( 28745844 )
2017
33
Challenges surrounding penile prostheses insertion following acute priapism. ( 29239397 )
2017
34
Priapism Associated With Antipsychotic Medication Use: Case Report. ( 28590368 )
2017
35
Hallucination and priapism associated with methylphenidate usage: Two case reports. ( 29085103 )
2017
36
Priapism in the Newborn: Shall We Intervene? ( 28083497 )
2017
37
Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism. ( 29278308 )
2017
38
The management of the acute ischemic priapism: A state of the art review. ( 28528136 )
2017
39
Guideline of guidelines: priapism. ( 27860090 )
2017
40
Thalassemia Major and Priapism: A Case Report of an Adolescent. ( 28538505 )
2017
41
Avoiding complications: surgery for ischemic priapism. ( 28904898 )
2017
42
Priapism associated with the addition of risperidone to methylphenidate monotherapy: a case report. ( 28752150 )
2017
43
Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression. ( 29110178 )
2017
44
Management of refractory ischemic priapism: current perspectives. ( 28920056 )
2017
45
Ultrasound-guided penile nerve block in pediatrics: An answer to intraoperative priapism. ( 28757858 )
2017
46
Advances in the understanding of priapism. ( 28540227 )
2017
47
The Semantics of Priapism and the First Sign of Chronic Myeloid Leukemia. ( 28638667 )
2017
48
The use of penile prostheses in the management of priapism. ( 29238659 )
2017
49
Management in Neonatal Priapism: Case and Review. ( 28752068 )
2017
50
Contemporary best practice in the evaluation and management of stuttering priapism. ( 28932276 )
2017

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

Pathways related to Priapism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 F13A1 F5 ITGAV NOS3 PDE5A
2
Show member pathways
11.92 ITGAV NOS3 TGFBR3
3
Show member pathways
10.88 NOS3 PDE5A
4 10.75 ITGAV NOS3 TGFBR3
5 10.07 NOS3 PDE5A

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 F13A1 F5 GNRH1 HP KL TGFBR3
2 platelet alpha granule lumen GO:0031093 8.96 F13A1 F5

Biological processes related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 8.96 F13A1 F5
2 response to prostaglandin E GO:0034695 8.62 GNRH1 TGFBR3

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.16 ITGAV TGFBR3
2 transforming growth factor beta binding GO:0050431 8.96 ITGAV TGFBR3
3 fibroblast growth factor binding GO:0017134 8.8 ITGAV KL TGFBR3

Sources for Priapism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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