MCID: PRP007
MIFTS: 46

Priapism

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Priapism

MalaCards integrated aliases for Priapism:

Name: Priapism 12 20 54 44 15 70 32
Priapism, Familial Idiopathic 20 70
Familial Idiopathic Priapism 20
Mentulagra 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9286
ICD9CM 34 607.3
MeSH 44 D011317
NCIt 50 C85022
SNOMED-CT 67 155930001
ICD10 32 N48.3
UMLS 70 C0033117 C1867771

Summaries for Priapism

Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to sickle cell disease and impotence, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Calcium signaling pathway. The drugs Sodium citrate and Hydroxyurea have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 31.0 NOS3 HP HBB
2 impotence 31.0 PDE5A NOS3 NOS2 GNRH1 ARG2
3 prostatic hyperplasia, benign 30.3 PDE5A ADRA1A
4 sickle cell anemia 30.2 TGFBR3 NOS3 HBB ADA
5 sexual disorder 30.2 PDE5A NOS3 GNRH1 ARG2
6 glucosephosphate dehydrogenase deficiency 29.9 SLC4A1 HP HBB
7 peyronie disease 29.9 PDE5A NOS2
8 vasculogenic impotence 29.9 PDE5A ADA
9 pulmonary edema 29.6 NOS3 NOS2 HP
10 beta-thalassemia 29.5 SLC4A1 KL HBB F5
11 hereditary spherocytosis 29.2 SLC4A1 HP HBB AQP1
12 hemolytic anemia 29.2 SLC4A1 HP HBB ADA
13 congenital hemolytic anemia 28.8 SLC4A1 HP HBB ADA
14 low-flow priapism 11.3
15 persistent genital arousal disorder 11.0
16 priapism, familial idiopathic 11.0
17 stuttering 10.7
18 leukemia, chronic myeloid 10.4
19 deficiency anemia 10.4
20 myeloid leukemia 10.4
21 hemoglobinopathy 10.3
22 arteritic anterior ischemic optic neuropathy 10.3 NOS3 F5
23 thalassemia 10.3
24 platelet membrane fluidity 10.3 NOS3 NOS2
25 acquired angioedema 10.2 HP F5
26 leukemia 10.2
27 hydrarthrosis 10.2 MIP AQP1
28 chronic pulmonary heart disease 10.2 PDE5A NOS3 HP
29 transitional cell carcinoma 10.2
30 spinal stenosis 10.2
31 compartment syndrome 10.2
32 spinal cord injury 10.2
33 nonarteritic anterior ischemic optic neuropathy 10.2 PDE5A NOS3 F5
34 pyometritis 10.2 HP GNRH1
35 ureterolithiasis 10.1 PDE5A ADRA1A
36 bladder cancer 10.1
37 purpura 10.1
38 anoxia 10.1
39 anemia, congenital dyserythropoietic, type ib 10.1 HP AQP1
40 dysferlinopathy 10.1 MIP AQP1
41 attention deficit-hyperactivity disorder 10.1
42 hypogonadism 10.1
43 renal cell carcinoma, nonpapillary 10.1
44 leukemia, acute lymphoblastic 10.1
45 peyronie's disease 10.1
46 thrombosis 10.1
47 prostatic hypertrophy 10.1
48 prostatic adenoma 10.1
49 migraine with aura 10.1 NOS3 F5 AQP1
50 myeloma, multiple 10.0

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

GenomeRNAi Phenotypes related to Priapism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-2 9.62 ITGAV
2 Decreased viability GR00249-S 9.62 ARG2 F13A1 F5 HP ITGAV MIP
3 Decreased viability GR00381-A-1 9.62 ADRA1A AQP1 ITGAV
4 Decreased viability GR00386-A-1 9.62 ARG2 ITGAV KL NOS3 OPRPN
5 Decreased viability GR00402-S-2 9.62 ADORA2B ADRA1A AQP1

MGI Mouse Phenotypes related to Priapism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 ADA ADORA2B ADRA1A AQP1 F13A1 F5
2 homeostasis/metabolism MP:0005376 10.25 ADA ADORA2B ADRA1A AQP1 ARG2 F13A1
3 hematopoietic system MP:0005397 10.21 ADA ADORA2B AQP1 F13A1 GNRH1 HP
4 immune system MP:0005387 10.11 ADA ADORA2B AQP1 GNRH1 HP ITGAV
5 mortality/aging MP:0010768 10.07 ADA ADORA2B ADRA1A AQP1 F13A1 F5
6 liver/biliary system MP:0005370 9.92 ADA F5 GNRH1 HP KL NOS2
7 muscle MP:0005369 9.76 ADA ADRA1A ITGAV KL NOS2 NOS3
8 renal/urinary system MP:0005367 9.7 ADA ADORA2B ADRA1A AQP1 GNRH1 HP
9 reproductive system MP:0005389 9.28 ADA ADORA2B AQP1 F13A1 GNRH1 KL

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 2 68-04-2
2
Hydroxyurea Approved Phase 2 127-07-1 3657
3
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
4 Citrate Phase 2
5 Sildenafil Citrate Phase 2 171599-83-0
6 Immunoglobulins Phase 2
7 Antibodies Phase 2
8 Antibodies, Monoclonal Phase 2
9 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
2 A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Blind, 12-Month Study to Assess Safety and Efficacy of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Sickle Cell-Related Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
3 A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (Crizanlizumab), in Sickle Cell Disease Patients With Priapism (SPARTAN) Recruiting NCT03938454 Phase 2 crizanlizumab
4 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
5 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Unknown status NCT02539771
6 The Epidemiology of Priapism (Sickle Cell Disease) Completed NCT00300235
7 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

MalaCards organs/tissues related to Priapism:

40
Myeloid, Prostate, Spinal Cord, Kidney, Brain, Smooth Muscle, Heart

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 2776)
# Title Authors PMID Year
1
Phosphodiesterase type 5 regulation in the penile corpora cavernosa. 61 54
19267844 2009
2
Sickle cell trait and priapism: a case report and review of the literature. 61 54
19116025 2008
3
Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism? 61 54
17971109 2008
4
Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health. 54 61
17942972 2008
5
Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. 54 61
17100941 2006
6
Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism. 61 54
16698365 2006
7
Tissue expression, distribution, and regulation of PDE5. 61 54
15224128 2004
8
Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. 61 54
12853767 2003
9
High flow or low flow? An unusual case of ischemic priapism following gunshot wound to the cervical spinal cord. 61
33747794 2021
10
Spectrum of urological emergencies and surgical interventions in a single tertiary health center. 61
33680746 2021
11
SARS-CoV-2 infection affects the lower urinary tract and male genital system: A systematic review. 61
33595134 2021
12
Psychotropic-Induced Priapism in a Treatment-Refractory Patient: A Case Report. 61
31694449 2021
13
Treatment-resistant priapism associated with long-term low-molecular-weight heparin. 61
33795288 2021
14
Protective effects of dexmedetomidine on ischaemia-reperfusion injury in an experimental rat model of priapism. 61
33474739 2021
15
Alpha thalassemia, but not βS-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort. 61
33586016 2021
16
A coronavirus disease 2019 (COVID-19) patient with bilateral orchitis. 61
32888763 2021
17
TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production. 61
32974910 2021
18
Priapism, a symptom of claudication of the cauda equina in spinal stenosis. 61
33549525 2021
19
Emergency department management of ischaemic priapism. 61
33759342 2021
20
Recurrent priapism in spinal cord injury: A case report. 61
31074709 2021
21
Abdominal Manifestations of Sickle Cell Disease. 61
32564896 2021
22
A rare case of post-traumatic high-flow priapism requiring endovascular salvage with bilateral superselective microcoil embolization. 61
33732429 2021
23
Effectiveness of the caverno-dorsal vein shunt (Barry shunt) on prolonged ischaemic priapism and its effect on the post-operative long-term erectile function. 61
33368421 2021
24
Medicinal plants as a potential source of Phosphodiesterase-5 inhibitors: A review. 61
33137431 2021
25
Priapism following a juvenile Russell's viper bite: An unusual case report. 61
33764978 2021
26
Is priapism a common presentation of chronic myeloid leukemia in an adolescent patient. 61
33797372 2021
27
Endovascular Interventional Radiology of the Urogenital Tract. 61
33802895 2021
28
Regimented Phosphodiesterase Type 5 Inhibitor Use Reduces Emergency Department Visits for Recurrent Ischemic Priapism. 61
32915079 2021
29
Malignant priapism in metastatic adenocarcinoma of gastrointestinal origin: A 18 F-FDG PET/CT study. 61
33634572 2021
30
A training model to teach early management of priapism. 61
33541743 2021
31
Priapism Associated With Cabergoline In A Young Adult. 61
32402771 2021
32
Cell-derived microparticles and sickle cell disease chronic vasculopathy in sub-Saharan Africa: A multinational study. 61
33249569 2021
33
Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis. 61
32949984 2021
34
Patient Education Is Associated With Reduced Delay to Presentation for Management of Ischemic Priapism: A Retrospective Review of 123 Men. 61
33422447 2021
35
Psychometric Impact of Priapism on Lives of Adolescents and Adults With Sickle Cell Anemia: A Sequential Independent Mixed-Methods Design. 61
33560078 2021
36
Automated Red Cell Exchange in the Management of Sickle Cell Disease. 61
33671876 2021
37
A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: A CARE-compliant report. 61
33537133 2021
38
Rare Disorders of Painful Erection: A Cohort Study of the Investigation and Management of Stuttering Priapism and Sleep-Related Painful Erection. 61
33390335 2021
39
Medical treatment of recurrent ischaemic priapism: a review of current molecular therapeutics and a new clinical management paradigm. 61
33606327 2021
40
Melanotan Tanning Injection: A Rare Cause of Priapism. 61
33460908 2021
41
Pretreatment screening and counseling on prolonged erections for patients prescribed trazodone. 61
33314808 2021
42
Combination therapy with topical alprostadil and phosphodiesterase-5 inhibitors after failure of oral therapy in patients with erectile dysfunction: a prospective, two-arm, open-label, non-randomized study. 61
33483603 2021
43
Essential thrombocythemia with (type2) calreticulin presented as stuttering priapism case report and review of literature. 61
33489189 2021
44
Priapism in COVID-19: A thromboembolic complication. 61
33551247 2021
45
Priapism in a patient with coronavirus disease 2019 (COVID-19). 61
32732087 2021
46
[When a urological emergency indicates an internal medical crisis : Priapism as the first clinical manifestation of leukemia]. 61
32936336 2021
47
Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers. 61
33539452 2021
48
[Intracerebral hemorrhage as the cause of low-flow priapism : A rare association]. 61
32852604 2021
49
Triage of urology service to cope with COVID-19 pandemic: A single institution study. 61
33510591 2021
50
Priapism and cannabism: A case report and review of the literature. 61
33342537 2020

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.1 TGFBR3 SLC4A1 NOS3 NOS2 MIP KL
2 extracellular space GO:0005615 9.76 TGFBR3 OPRPN KL HP HBB GNRH1
3 endocytic vesicle lumen GO:0071682 9.37 HP HBB
4 haptoglobin-hemoglobin complex GO:0031838 9.26 HP HBB
5 blood microparticle GO:0072562 9.26 SLC4A1 HP HBB F13A1
6 integral component of plasma membrane GO:0005887 9.23 TGFBR3 SLC4A1 MIP KL ITGAV AQP1

Biological processes related to Priapism according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.71 SLC4A1 HBB F5 F13A1
2 aging GO:0007568 9.56 KL GNRH1 ADRA1A ADA
3 positive regulation of smooth muscle contraction GO:0045987 9.54 ADRA1A ADA
4 response to hormone GO:0009725 9.54 NOS3 NOS2 ADRA1A
5 nitric oxide mediated signal transduction GO:0007263 9.52 NOS3 NOS2
6 water transport GO:0006833 9.51 MIP AQP1
7 response to hydrogen peroxide GO:0042542 9.5 HP HBB ADA
8 positive regulation of guanylate cyclase activity GO:0031284 9.49 NOS3 NOS2
9 response to prostaglandin E GO:0034695 9.48 TGFBR3 GNRH1
10 negative regulation of oxidoreductase activity GO:0051354 9.46 SLC4A1 HP
11 arginine catabolic process GO:0006527 9.43 NOS3 NOS2
12 bicarbonate transport GO:0015701 9.33 SLC4A1 HBB AQP1
13 nitric oxide transport GO:0030185 8.96 HBB AQP1
14 nitric oxide biosynthetic process GO:0006809 8.8 NOS3 NOS2 ARG2

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.46 NOS3 NOS2
2 FMN binding GO:0010181 9.43 NOS3 NOS2
3 water channel activity GO:0015250 9.4 MIP AQP1
4 arginine binding GO:0034618 9.37 NOS3 NOS2
5 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS3 NOS2
6 tetrahydrobiopterin binding GO:0034617 9.26 NOS3 NOS2
7 nitric-oxide synthase activity GO:0004517 9.16 NOS3 NOS2
8 fibroblast growth factor binding GO:0017134 9.13 TGFBR3 KL ITGAV
9 hemoglobin binding GO:0030492 8.8 SLC4A1 HP HBB

Sources for Priapism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....