MCID: PRP007
MIFTS: 46

Priapism

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Reproductive diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Priapism

MalaCards integrated aliases for Priapism:

Name: Priapism 11 19 53 43 14 71 75 31 33
Priapism, Familial Idiopathic 19 71
Mentulagra 11 33
Familial Idiopathic Priapism 19
Pathologic Erection 33
Painful Erection 33

Classifications:



External Ids:

Disease Ontology 11 DOID:9286
ICD9CM 34 607.3
MeSH 43 D011317
NCIt 49 C85022
SNOMED-CT 68 155930001
ICD10 31 N48.3
ICD11 33 1983776037
UMLS 71 C0033117 C1867771

Summaries for Priapism

Disease Ontology: 11 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary: Priapism, also known as priapism, familial idiopathic, is related to impotence and peyronie's disease, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and superpathway of L-citrulline metabolism. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, myeloid and prostate, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia: 75 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 375)
# Related Disease Score Top Affiliating Genes
1 impotence 31.2 PDE5A NOS3 NOS2 EDN1 ARG2
2 peyronie's disease 30.6 PDE5A NOS3
3 sickle cell anemia 30.6 HP HBB EDN1 BCL11A
4 prostatic hyperplasia, benign 30.4 PDE5A ADRA1A
5 thrombophilia 30.2 NOS3 F5 F13A1
6 sexual health disorder 30.2 PDE5A GNRH1
7 pulmonary embolism 30.1 PDE5A F5 F13A1
8 glucosephosphate dehydrogenase deficiency 30.0 SLC4A1 HP HBB
9 peyronie disease 30.0 PDE5A NOS2
10 hemoglobinopathy 29.9 HP HBB BCL11A
11 ureterolithiasis 29.8 PDE5A ADRA1A
12 chronic kidney disease 29.8 NOS3 KL HP EDN1
13 pulmonary hypertension 29.8 PDE5A NOS3 NOS2 EDN1 AQP1
14 polycythemia 29.7 HBB F5 EDN1
15 thalassemia 29.7 SLC4A1 HP HBB BCL11A
16 autosomal dominant polycystic kidney disease 29.7 NOS3 KL EDN1 AQP1
17 hereditary spherocytosis 29.6 SLC4A1 HP HBB AQP1
18 ischemia 29.6 PDE5A NOS3 NOS2 EDN1
19 pulmonary edema 29.5 NOS3 NOS2 HP EDN1
20 vascular disease 29.4 PDE5A NOS3 NOS2 HP F5 EDN1
21 hemolytic anemia 29.3 SLC4A1 HP HBB BCL11A
22 hemoglobin c disease 29.3 HBB BCL11A
23 beta-thalassemia 29.2 SLC4A1 KL HBB F5 BCL11A
24 myocardial infarction 29.2 PDE5A NOS3 NOS2 HP F5 F13A1
25 alpha-thalassemia 29.0 SLC4A1 HP HBB BCL11A
26 hemoglobin e disease 28.9 HBB BCL11A
27 malaria 28.9 SLC4A1 NOS3 NOS2 HP HBB EDN1
28 acute chest syndrome 28.9 NOS3 HP HBB EDN1 BCL11A
29 congenital hemolytic anemia 28.8 SLC4A1 HP HBB BCL11A
30 hypertension, essential 28.5 PDE5A NOS3 NOS2 KL HP EDN1
31 low-flow priapism 11.3
32 priapism, familial idiopathic 11.0
33 scorpion envenomation 11.0
34 sickle cell disease 10.9
35 stuttering 10.7
36 leukemia, chronic myeloid 10.6
37 myeloid leukemia 10.5
38 deficiency anemia 10.5
39 bladder cancer 10.3
40 kidney hypertrophy 10.3 NOS3 KL
41 renal cell carcinoma, nonpapillary 10.2
42 fabry disease 10.2
43 cauda equina syndrome 10.2
44 glanders 10.2
45 compartment syndrome 10.2
46 buerger disease 10.2 NOS3 EDN1
47 leukemia, acute lymphoblastic 10.2
48 transitional cell carcinoma 10.2
49 spinal stenosis 10.2
50 hydrarthrosis 10.2 MIP AQP1

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

GenomeRNAi Phenotypes related to Priapism according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.2 ADORA2B ADRA1A AQP1 ARG2 BCL11A EDN1
2 no effect GR00402-S-2 10.2 ADRA1A ARG2 BCL11A EDN1 F13A1 F5

MGI Mouse Phenotypes related to Priapism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ADORA2B ADRA1A AQP1 ARG2 BCL11A EDN1
2 renal/urinary system MP:0005367 10.26 ADORA2B ADRA1A AQP1 EDN1 GNRH1 HP
3 cardiovascular system MP:0005385 10.13 ADORA2B ADRA1A AQP1 EDN1 F13A1 F5
4 muscle MP:0005369 10.11 ADRA1A EDN1 HBB ITGAV KL NOS2
5 liver/biliary system MP:0005370 10.09 F5 GNRH1 HBB HP KL NOS2
6 endocrine/exocrine gland MP:0005379 10.07 AQP1 BCL11A EDN1 F13A1 GNRH1 ITGAV
7 immune system MP:0005387 10.07 ADORA2B AQP1 BCL11A GNRH1 HBB HP
8 skeleton MP:0005390 9.81 AQP1 EDN1 GNRH1 HBB KL NOS2
9 hematopoietic system MP:0005397 9.8 ADORA2B AQP1 BCL11A F13A1 GNRH1 HBB
10 mortality/aging MP:0010768 9.5 ADORA2B ADRA1A AQP1 BCL11A EDN1 F13A1

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 2 68-04-2 23431961
2
Sildenafil Approved, Investigational Phase 2 139755-83-2, 171599-83-0 5212 135398744
3
Hydroxyurea Approved Phase 2 127-07-1 3657
4
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
5 Citrate Phase 2
6 Immunoglobulins Phase 2
7 Pharmaceutical Solutions Phase 2
8 Antibodies, Monoclonal Phase 2
9 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
2 A Randomized Controlled Double-Blind Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study Recruiting NCT05142254 Phase 2 Tadalafil;Hydroxyurea;Placebo
3 A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (Crizanlizumab), in Sickle Cell Disease Patients With Priapism (SPARTAN) Recruiting NCT03938454 Phase 2 crizanlizumab
4 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
5 The Epidemiology of Priapism (Sickle Cell Disease) Completed NCT00300235
6 ManAgement of pRiapiSm and Its Impact on Outcomes: an International Register Enrolling by invitation NCT04932902
7 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

Organs/tissues related to Priapism:

MalaCards : Spinal Cord, Myeloid, Prostate, Smooth Muscle, Skin, Kidney, Brain

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 2999)
# Title Authors PMID Year
1
Phosphodiesterase type 5 regulation in the penile corpora cavernosa. 53 62
19267844 2009
2
Sickle cell trait and priapism: a case report and review of the literature. 53 62
19116025 2008
3
Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism? 53 62
17971109 2008
4
Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health. 53 62
17942972 2008
5
Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. 53 62
17100941 2006
6
Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism. 53 62
16698365 2006
7
Tissue expression, distribution, and regulation of PDE5. 53 62
15224128 2004
8
Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. 53 62
12853767 2003
9
Reversed priapism, thrombosis of the dorsal penile vein: A case report. 62
36439923 2023
10
Prolonged penile erection: A case report of ischemic priapism. 62
35842387 2022
11
Go the Distance: Reproductive Health Care for People with Sickle Cell Disease. 62
36400542 2022
12
Clinical Vignettes Part I. 62
36400538 2022
13
Single dose Tadalafil 5 mg in Muscle Invasive Bladder Cancer (MIBC) patient induce priapism: A case report and literature review. 62
36062202 2022
14
A Case of Priapism in a Child With Autism Spectrum Disorder, Possibly Due to Risperidone Treatment With Addition of Atomoxetine. 62
36093917 2022
15
PHIL® (precipitating hydrophobic injectable liquid): retrospective multicenter experience on 178 patients in peripheral embolizations. 62
36070065 2022
16
Bilateral Simultaneous Optic Neuritis Following Envenomations by Indian Cobra and Common Krait. 62
36422979 2022
17
Treatment patterns and burden of complications associated with sickle cell disease: A US retrospective claims analysis. 62
36467832 2022
18
The value of leukapheresis for treatment of priapism as presenting feature of chronic myeloid leukemia-Case report and review of literature. 62
36467799 2022
19
Safety and Efficacy of Phenylephrine Administration for the Treatment of Ischemic Priapism: An Opportunity for Quality Improvement in Periprocedural Safety Assessment. 62
36007685 2022
20
Lamotrigine induced priapism in children: case analysis and literature review. 62
36418928 2022
21
3D-printed procedural task trainer for the aspiration of penile corpus cavernosa in ischaemic priapism. 62
36351564 2022
22
Insertion of Penile Implants in Patients with Priapism: When Is the Right Time? 62
36396558 2022
23
Intracavernosal abscess: An unusual finding during repair of neglected penile fracture. 62
36406007 2022
24
Super-selective Gelfoam embolisation in high-flow priapism. 62
36203271 2022
25
[Sexuality assessment of homozygous adult sickle cell patients with a history of priapism in Senegal]. 62
35623942 2022
26
Priapism or Prolonged Erection: Is 4 - 6 Hours of Cavernous Ischemia the Time Point of Irreversible Tissue Injury? 62
36028433 2022
27
Getting the diagnosis of priapism wrong; when not to aspirate. 62
35747930 2022
28
Priapism and Second-Generation Antipsychotics: Disproportionality Analysis of a Spontaneous Reporting System Database in Japan. 62
35779005 2022
29
Intravascular hemolysis leads to exaggerated corpus cavernosum relaxation: Implication for priapism in sickle cell disease. 62
36070139 2022
30
Surgical tips in difficult penile prosthetic surgery: a narrative review. 62
36261536 2022
31
Incidence and predictors of priapism events in sickle cell anemia: a diary-based analysis. 62
35816639 2022
32
The Risk of Cardiovascular and Cerebrovascular Disease in Men With a History of Priapism. 62
36083148 2022
33
The International Penile Prosthesis Implant Consensus Forum: clinical recommendations and surgical principles on the inflatable 3-piece penile prosthesis implant. 62
35711059 2022
34
Risperidone-Induced Priapism in a Patient With Hereditary Spherocytosis: A Case Report. 62
36127028 2022
35
Buprenorphine/naloxone (Suboxone®) withdrawal may facilitate antipsychotic-induced priapism. A case report. 62
36200467 2022
36
Differences in polysomnographic, nocturnal penile tumescence and penile doppler ultrasound findings in men with stuttering priapism and sleep-related painful erections. 62
34389802 2022
37
Stuttering Priapism in a Dog-First Report. 62
36288131 2022
38
Probable drug-induced clitoral priapism due to potentiating effects of pregabalin and duloxetine. 62
36112421 2022
39
Surgical and minimally invasive treatment of ischaemic and non-ischaemic priapism: a systematic review by the EAU Sexual and Reproductive Health Guidelines panel. 62
36151318 2022
40
Improvement of associated symptoms using combined therapy in 44 patients with sleep-related painful erection during 1-year follow up. 62
35593076 2022
41
An overview of emergency pharmacotherapy for priapism. 62
35815373 2022
42
Physiopathology of the Priapism Secondary to Tamsulosin: Clinical Cases of Our Hospital and Literature Review. 62
36138510 2022
43
A case of non-ischemic priapism in a healthy 7-year-old boy. 62
35919511 2022
44
Development of Wunderlich syndrome following a Russell's viper bite. 62
35691405 2022
45
Complex Penile Surgery: Plication, Grafting, and Implants. 62
35931434 2022
46
Is urgent surgical management necessary for priapism in pediatric patients with hematologic conditions? 62
35843787 2022
47
Conservative and medical treatments of non-sickle cell disease-related ischemic priapism: a systematic review by the EAU Sexual and Reproductive Health Panel. 62
35995858 2022
48
What is the effectiveness of surgical and non-surgical therapies in the treatment of ischemic priapism in patients with sickle cell disease? A systematic review by the EAU Sexual and Reproductive Health Guidelines Panel. 62
35941221 2022
49
Management of acute sickle cell priapism in an African (Togo) pediatric department includes conservative measures and intracavernous epinephrine which is safe and efficacious. 62
36051024 2022
50
Priapism Secondary to Low-Molecular-Weight Heparins: A Case Report. 62
36036725 2022

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

Pathways related to Priapism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 PDE5A NOS3 NOS2 ITGAV HBB F5
2
Show member pathways
11.6 NOS3 NOS2 ARG2
3 11.53 TGFBR3 NOS3 ITGAV
4
Show member pathways
11.44 NOS3 NOS2 EDN1
5
Show member pathways
11.01 PDE5A NOS3 NOS2
6
Show member pathways
10.89 SLC4A1 HBB AQP1
7 10.62 NOS3 EDN1 ADRA1A
8 9.91 PDE5A NOS3 NOS2

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 TGFBR3 SLC4A1 MIP KL ITGAV AQP1
2 plasma membrane GO:0005887 9.7 TGFBR3 SLC4A1 MIP KL ITGAV AQP1
3 blood microparticle GO:0072562 9.56 SLC4A1 HP HBB F13A1
4 haptoglobin-hemoglobin complex GO:0031838 9.46 HP HBB

Biological processes related to Priapism according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to hormone GO:0009725 9.93 NOS3 NOS2 ADRA1A
2 positive regulation of cardiac muscle hypertrophy GO:0010613 9.8 ADRA1A EDN1 PDE5A
3 arginine catabolic process GO:0006527 9.78 NOS3 NOS2
4 blood vessel diameter maintenance GO:0097746 9.77 NOS3 HBB EDN1
5 negative regulation of oxidoreductase activity GO:0051354 9.73 SLC4A1 HP
6 regulation of blood pressure GO:0008217 9.73 NOS3 HBB EDN1 ADRA1A
7 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.71 NOS3 EDN1
8 nitric oxide biosynthetic process GO:0006809 9.63 NOS3 NOS2 ARG2
9 cellular biosynthetic process GO:0044249 9.49 NOS3 NOS2
10 positive regulation of guanylate cyclase activity GO:0031284 9.43 NOS3 NOS2 ADORA2B
11 nitric oxide transport GO:0030185 9.1 HBB EDN1 AQP1

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 arginine binding GO:0034618 9.62 NOS3 NOS2
2 tetrahydrobiopterin binding GO:0034617 9.56 NOS3 NOS2
3 nitric-oxide synthase activity GO:0004517 9.46 NOS3 NOS2
4 fibroblast growth factor binding GO:0017134 9.43 TGFBR3 KL ITGAV
5 hemoglobin binding GO:0030492 9.1 SLC4A1 HP HBB

Sources for Priapism

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....