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MCID: PRP007
MIFTS: 54

Priapism

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Priapism

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MalaCards integrated aliases for Priapism:

Name: Priapism 12 54 56 45 15 74
Priapism, Familial Idiopathic 54 74
Familial Idiopathic Priapism 54
Mentulagra 12

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Reproductive diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:9286
ICD9CM 36 607.3
MeSH 45 D011317
NCIt 51 C85022
SNOMED-CT 69 4287008 6273006
ICD10 34 N48.3 N48.30
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Summaries for Priapism

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Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to impotence and sexual disorder, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Sertoli-Sertoli Cell Junction Dynamics. The drugs Prazosin and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 77 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

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Related Diseases for Priapism

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Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 impotence 30.5 NOS2 NOS3 PDE5A
2 sexual disorder 30.2 NOS3 PDE5A
3 vasculogenic impotence 29.9 NOS3 PDE5A
4 homocysteinemia 29.5 F5 NOS3
5 pulmonary hypertension 29.4 NOS2 NOS3 PDE5A
6 intracranial hypertension 29.3 AQP1 F5
7 myocardial infarction 29.3 F13A1 F5 NOS3 PDE5A
8 autosomal dominant polycystic kidney disease 29.2 AQP1 KL NOS3
9 low-flow priapism 12.4
10 priapism, familial idiopathic 12.1
11 persistent genital arousal disorder 11.5
12 sickle cell disease 10.7
13 stuttering 10.5
14 leukemia 10.5
15 sickle cell anemia 10.5
16 myeloid leukemia 10.3
17 penile disease 10.2 NOS3 PDE5A
18 thrombosis 10.2
19 persistent fetal circulation syndrome 10.2 NOS3 PDE5A
20 carotid artery occlusion 10.2 F5 NOS3
21 thalassemia 10.2
22 factor xiii deficiency 10.2 F13A1 F5
23 peyronie disease 10.2 NOS2 PDE5A
24 schizophrenia 10.1
25 adenocarcinoma 10.1
26 platelet membrane fluidity 10.1 NOS2 NOS3
27 dysfibrinogenemia 10.1 F13A1 F5
28 prostate cancer 10.1
29 prostate cancer, hereditary, 8 10.1
30 prostate cancer, hereditary, 6 10.1
31 arteritic anterior ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
32 ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
33 spinal cord injury 10.1
34 nonarteritic anterior ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
35 hepatopulmonary syndrome 10.0 NOS2 NOS3
36 myeloma, multiple 10.0
37 spinal stenosis 10.0
38 lymphocytic leukemia 10.0
39 purpura 10.0
40 bladder cancer 9.9
41 renal cell carcinoma, nonpapillary 9.9
42 thrombophilia due to thrombin defect 9.9
43 fabry disease 9.9
44 suppression of tumorigenicity 12 9.9
45 malaria 9.9
46 leukemia, acute lymphoblastic 9.9
47 arteriovenous fistula 9.9
48 lymphoma 9.9
49 rabies 9.9
50 transitional cell carcinoma 9.9

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism
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Symptoms & Phenotypes for Priapism

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UMLS symptoms related to Priapism:


painful erection

MGI Mouse Phenotypes related to Priapism:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.15 AQP1 F13A1 F5 ITGAV KL NOS2
2 hematopoietic system MP:0005397 10.03 AQP1 F13A1 ITGAV KL NOS2 NOS3
3 homeostasis/metabolism MP:0005376 10.01 AQP1 F13A1 F5 ITGAV KL NOS2
4 growth/size/body region MP:0005378 10 AQP1 F5 ITGAV KL NOS2 NOS3
5 mortality/aging MP:0010768 9.97 AQP1 F13A1 F5 ITGAV KL NOS2
6 endocrine/exocrine gland MP:0005379 9.95 AQP1 F13A1 ITGAV KL NOS2 NOS3
7 liver/biliary system MP:0005370 9.77 F5 KL NOS2 NOS3 TGFBR3
8 muscle MP:0005369 9.73 ITGAV KL NOS2 NOS3 SLC4A1 TGFBR3
9 renal/urinary system MP:0005367 9.63 AQP1 ITGAV KL NOS2 NOS3 SLC4A1
10 reproductive system MP:0005389 9.43 AQP1 F13A1 KL NOS2 NOS3 TGFBR3
11 respiratory system MP:0005388 9.02 AQP1 F13A1 KL NOS2 NOS3
Sources

Drugs & Therapeutics for Priapism

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Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
3 Anti-Infective Agents Phase 3,Phase 1,Phase 2
4 Adrenergic Antagonists Phase 3
5 Adrenergic alpha-1 Receptor Antagonists Phase 3
6 Neurotransmitter Agents Phase 3
7 Adrenergic alpha-Antagonists Phase 3
8 Adrenergic Agents Phase 3
9 Antihypertensive Agents Phase 3
10 Protective Agents Phase 3
11 Respiratory System Agents Phase 3
12 Free Radical Scavengers Phase 3
13 Expectorants Phase 3
14 N-monoacetylcystine Phase 3
15 Antidotes Phase 3
16 Antiviral Agents Phase 3
17 Antioxidants Phase 3
18
Hydroxyurea Approved Phase 1, Phase 2,Phase 2 127-07-1 3657
19
alemtuzumab Approved, Investigational Phase 1, Phase 2,Phase 2 216503-57-0
20
Everolimus Approved Phase 1, Phase 2,Phase 2 159351-69-6 6442177 70789204
21
Sirolimus Approved, Investigational Phase 1, Phase 2,Phase 2 53123-88-9 46835353 6436030 5284616
22
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Phase 2 22916-47-8 4189
23
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
24
Sodium Citrate Approved, Investigational Phase 2 68-04-2
25
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 2713 9552079
26
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
27
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
28 Immunologic Factors Phase 1, Phase 2,Phase 2
29 Antibiotics, Antitubercular Phase 1, Phase 2,Phase 2
30 Antifungal Agents Phase 1, Phase 2,Phase 2
31 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
32 Antineoplastic Agents, Immunological Phase 1, Phase 2,Phase 2
33 Anti-Bacterial Agents Phase 1, Phase 2,Phase 2
34 Antineoplastic Agents, Alkylating Phase 2
35 Trichostatin A Phase 2
36 Antirheumatic Agents Phase 2
37 Alkylating Agents Phase 2
38 Citrate Phase 2
39 Phosphodiesterase 5 Inhibitors Phase 2
40 Phosphodiesterase Inhibitors Phase 2
41 Sildenafil Citrate Phase 2 171599-83-0
42 Vasodilator Agents Phase 2
43 Immunoglobulins Phase 2
44 Antibodies, Monoclonal Phase 2
45 Antibodies Phase 2
46 Nucleic Acid Synthesis Inhibitors Phase 2
47 Disinfectants Phase 2
48 Analgesics Phase 2
49 Dermatologic Agents Phase 2
50 Anti-Infective Agents, Local Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
2 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
3 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy Withdrawn NCT01560091 Phase 3 silodosin;Tamsulosin
4 Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) Unknown status NCT01499888 Phase 1, Phase 2 Alemtuzumab;Sirolimus
5 SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCD Unknown status NCT02013375 Phase 2 Alemtuzumab;Cyclophosphamide;Sirolimus
6 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
7 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
8 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
9 Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair & Same-Session Implantation Recruiting NCT03614429 Phase 2 Chlorhexidine gel will be prepared according to an international product Instillagel®
10 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
11 Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients Recruiting NCT03474965 Phase 2 Crizanlizumab
12 Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease Terminated NCT01987908 Phase 2 Aes-103
13 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
14 Sildenafil for Prevention of Cerebral Vasospasm Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
15 Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence Completed NCT00300235
16 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Recruiting NCT02539771 Not Applicable
17 Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE Recruiting NCT03352986
18 Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose Recruiting NCT03114137
19 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

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Genetic Tests for Priapism

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Anatomical Context for Priapism

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MalaCards organs/tissues related to Priapism:

42
Myeloid, Prostate, Spinal Cord, Bone, Heart, Bone Marrow, Smooth Muscle
Sources

Publications for Priapism

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Articles related to Priapism:

(show top 50) (show all 1519)
# Title Authors Year
1
Priapism following erector spinae plane block for the treatment of a complex regional pain syndrome. ( 30660341 )
2019
2
Priapism as a Debut Presentation of Chronic Myeloid Leukemia. ( 30630577 )
2019
3
Management of priapism with a trial of exercise in the emergency department. ( 29547365 )
2019
4
Immediate Placement of Penile Prosthesis for the Management of Ischemic Priapism as First-line Treatment. ( 30639251 )
2019
5
Re: Priapism throughout the Ages. ( 30664086 )
2019
6
Posttraumatic Arterial Priapism Treated with Superselective Embolization: Our Clinical Experience and a Review of the Literature. ( 30684137 )
2019
7
Ultrasound-Guided Dorsal Penile Neurolysis for Malignant Priapism Pain Management. ( 30686298 )
2019
8
Immediate Placement of a Penile Prosthesis as First-line Treatment for the Management of Ischaemic Priapism. ( 30691962 )
2019
9
Current practice in the management of ischemic priapism: an anonymous survey of ISSM members. ( 30718828 )
2019
10
Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade. ( 30719367 )
2019
11
Melanotan-induced priapism: a hard-earned tan. ( 30796078 )
2019
12
Comparison of outcomes in malignant vs. non-malignant ischemic priapism: 12-year experience from a tertiary center. ( 30817276 )
2019
13
Raising More Than Moods: Escitalopram-Associated Priapism. ( 30867630 )
2019
14
Management of Priapism: A Contemporary Review. ( 30898593 )
2019
15
A Systematic Review on Ischemic Priapism and Immediate Implantation: Do We Need More Data? ( 30898595 )
2019
16
Appropriate management of high-flow priapism based on color Doppler ultrasonography findings in pediatric patients: four case reports and a review of the literature. ( 30910454 )
2019
17
Ischemic priapism as a model of exhausted metabolism. ( 30916476 )
2019
18
Superselective Transcatheter Artery Embolization in Patients with Non-ischemic Priapism. ( 29417263 )
2018
19
Molecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability. ( 29394072 )
2018
20
Priapism caused by "Rhino 7 Platinum 3000" an over-the-counter male enhancement supplement. ( 29915255 )
2018
21
Daily tadalafil for the chronic phase of stuttering priapism: a case report. ( 29855284 )
2018
22
Priapism in sickle cell disease: Beware of neuroleptics. ( 29885077 )
2018
23
Comment on "Olanzapine-induced Priapism in a Child with Asperger's Syndrome". ( 29666039 )
2018
24
Prevalence and Characteristics of Priapism in Sickle Cell Disease. ( 29745276 )
2018
25
Through Clinical Observation: The History of Priapism After Spinal Cord Injuries. ( 29054772 )
2018
26
BAUS Consensus Document for the Management of Male Genital Emergencies - Priapism. ( 29357203 )
2018
27
Penoscrotal Decompression-Promising New Treatment Paradigm for Refractory Ischemic Priapism. ( 29550463 )
2018
28
Priapism as the initial sign in hematologic disease: Case report and literature review. ( 29414500 )
2018
29
Successful Management of Psychotropics Induced Stuttering Priapism with Pseudoephedrine in a Patient with Schizophrenia. ( 29713098 )
2018
30
Clitoral priapism due to distant clitoral metastasis of high-grade serous ovarian carcinoma: A case report and review of the literature. ( 29915806 )
2018
31
Case - Temporary chemical castration in the management of recurrent priapism. ( 29405906 )
2018
32
High-flow priapism and urinary retention. ( 29888190 )
2018
33
Priapism and hemodialysis: Case report and literature reviewa8c. ( 29578404 )
2018
34
Recent advances in the management of priapism. ( 29375820 )
2018
35
Prognosis of men with penile metastasis and malignant priapism: a systematic review. ( 29416825 )
2018
36
History of posttraumatic stress disorder A^ priapism A^ Dx? ( 29879245 )
2018
37
Spontaneous detumescence and full restoration of erection in a patient with high-flow priapism with persistent arterial-lacunar fistula after repeated selective embolisation-A case report. ( 29687468 )
2018
38
Poorly Controlled Homocystinuria: A Rare Cause of Ischemic Priapism? ( 29463473 )
2018
39
Commentary to "Ischemic priapism in pediatric patients: spontaneous detumescence with ketamine sedation". ( 29807704 )
2018
40
Ischemic priapism in pediatric patients: Spontaneous detumescence with ketamine sedation. ( 29936034 )
2018
41
Malignant priapism in metastatic prostate cancer: A late event occurring early. ( 29888172 )
2018
42
Penile Metastasis from Prostate Cancer Presenting as Malignant Priapism Detected Using Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography. ( 29430118 )
2018
43
Posttraumatic High-Flow Nonischemic Priapism. ( 29601467 )
2018
44
Role of Penile Prosthesis in Priapism: A Review. ( 29299902 )
2018
45
A new cause of ischaemic priapism: Synthetic cannabinoids. ( 29607523 )
2018
46
The Risks of Using Herbal Supplements for Sexual Dysfunction Associated With Psychotropic Medications: A Case Report of ExtenZe Use and Priapism. ( 29553994 )
2018
47
Priapism Throughout the Ages. ( 29729364 )
2018
48
The Hemodynamic Effects of Intracavernosal Phenylephrine for the Treatment of Ischemic Priapism. ( 29960632 )
2018
49
The first case of neonatal priapism during hypothermia for hypoxic-ischemic encephalopathy and a literature review. ( 30053817 )
2018
50
Priapism as a rare presentation of chronic myeloid leukemia. ( 30488874 )
2018
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Variations for Priapism

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Expression for Priapism

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Search GEO for disease gene expression data for Priapism.
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Pathways for Priapism

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Pathways related to Priapism according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 12.71 F13A1 F5 ITGAV NOS2 NOS3 PDE5A
2
Sertoli-Sertoli Cell Junction Dynamics 65
Show member pathways
 12.56 ITGAV NOS2 NOS3 TGFBR3
3
Insulin receptor recycling 67
Show member pathways
 12.16 NOS2 NOS3 SLC4A1
4
Apoptosis Pathway 73
Show member pathways
 12.12 ITGAV NOS3 TGFBR3
5
Development VEGF signaling via VEGFR2 - generic cascades 23
Show member pathways
 12.06 ITGAV NOS2 NOS3
6
Platelet homeostasis 67
Show member pathways
 11.86 NOS2 NOS3 PDE5A
7
Angiogenesis (CST) 4
11.45 ITGAV NOS3 TGFBR3
8
Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) 23
Show member pathways
 11.33 NOS2 NOS3
9
Arginine and proline metabolism 38
Show member pathways
 11.3 NOS2 NOS3
10
Doxorubicin Pathway, Pharmacokinetics 62
Show member pathways
 11.11 NOS2 NOS3
11
Ibuprofen Pathway, Pharmacodynamics 62
10.9 NOS2 NOS3
12
Arginine biosynthesis 38
Show member pathways
 10.85 NOS2 NOS3
13
Nitric oxide stimulates guanylate cyclase 67
Show member pathways
 10.76 NOS2 NOS3 PDE5A
14
Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics 62
10.75 NOS2 NOS3
15
Effects of Nitric Oxide 1
10.16 NOS2 NOS3
16
NO-dependent CFTR activation (normal and CF) 23
9.91 NOS2 NOS3 PDE5A
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GO Terms for Priapism

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Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.76 AQP1 F5 ITGAV KL NOS2 NOS3
2 integral component of plasma membrane GO:0005887 9.65 AQP1 ITGAV KL SLC4A1 TGFBR3
3 vesicle membrane GO:0012506 8.96 NOS2 NOS3
4 cortical cytoskeleton GO:0030863 8.62 NOS2 SLC4A1

Biological processes related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hormone GO:0009725 9.46 NOS2 NOS3
2 hemostasis GO:0007599 9.43 F13A1 F5
3 bicarbonate transport GO:0015701 9.4 AQP1 SLC4A1
4 ventricular septum morphogenesis GO:0060412 9.37 NOS3 TGFBR3
5 negative regulation of blood pressure GO:0045776 9.32 NOS2 NOS3
6 nitric oxide mediated signal transduction GO:0007263 9.26 NOS2 NOS3
7 nitric oxide biosynthetic process GO:0006809 9.16 NOS2 NOS3
8 positive regulation of guanylate cyclase activity GO:0031284 8.96 NOS2 NOS3
9 arginine catabolic process GO:0006527 8.62 NOS2 NOS3

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.46 NOS2 NOS3
2 coreceptor activity GO:0015026 9.43 ITGAV TGFBR3
3 transforming growth factor beta binding GO:0050431 9.4 ITGAV TGFBR3
4 FMN binding GO:0010181 9.37 NOS2 NOS3
5 arginine binding GO:0034618 9.32 NOS2 NOS3
6 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS2 NOS3
7 tetrahydrobiopterin binding GO:0034617 9.16 NOS2 NOS3
8 nitric-oxide synthase activity GO:0004517 8.96 NOS2 NOS3
9 fibroblast growth factor binding GO:0017134 8.8 ITGAV KL TGFBR3
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Sources for Priapism

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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