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MCID: PRP007
MIFTS: 51

Priapism

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Priapism

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MalaCards integrated aliases for Priapism:

Name: Priapism 12 54 56 45 15 74
Priapism, Familial Idiopathic 54 74
Familial Idiopathic Priapism 54
Mentulagra 12

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Reproductive diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:9286
ICD9CM 36 607.3
MeSH 45 D011317
NCIt 51 C85022
SNOMED-CT 69 4287008 6273006
ICD10 34 N48.3 N48.30
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Summaries for Priapism

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Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to impotence and sexual disorder, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Apoptosis Pathway. The drugs Prazosin and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, kidney and spinal cord, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 77 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

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Related Diseases for Priapism

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Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 impotence 30.9 NOS3 PDE5A
2 sexual disorder 30.2 NOS3 PDE5A
3 vasculogenic impotence 29.9 NOS3 PDE5A
4 thrombophilia due to thrombin defect 29.6 F13A1 F5
5 homocysteinemia 29.5 F5 NOS3
6 intracranial hypertension 29.3 AQP1 F5
7 myocardial infarction 29.2 F13A1 F5 NOS3 PDE5A
8 autosomal dominant polycystic kidney disease 29.2 AQP1 KL NOS3
9 low-flow priapism 12.4
10 priapism, familial idiopathic 12.1
11 persistent genital arousal disorder 11.5
12 sickle cell disease 10.7
13 stuttering 10.5
14 leukemia 10.5
15 sickle cell anemia 10.5
16 myeloid leukemia 10.3
17 penile disease 10.2 NOS3 PDE5A
18 persistent fetal circulation syndrome 10.2 NOS3 PDE5A
19 thalassemia 10.2
20 thrombosis 10.2
21 carotid artery occlusion 10.2 F5 NOS3
22 factor xiii deficiency 10.2 F13A1 F5
23 schizophrenia 10.1
24 spinal cord injury 10.1
25 adenocarcinoma 10.1
26 prostate cancer 10.1
27 prostate cancer, hereditary, 8 10.1
28 prostate cancer, hereditary, 6 10.1
29 dysfibrinogenemia 10.1 F13A1 F5
30 spinal stenosis 10.1
31 arteritic anterior ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
32 ischemic optic neuropathy 10.0 F5 NOS3 PDE5A
33 nonarteritic anterior ischemic optic neuropathy 10.0 F5 NOS3 PDE5A
34 bladder cancer 10.0
35 myeloma, multiple 10.0
36 lymphocytic leukemia 10.0
37 hemoglobinopathy 10.0
38 purpura 10.0
39 ovarian hyperstimulation syndrome 10.0 F5 GNRH1
40 renal cell carcinoma, nonpapillary 10.0
41 fabry disease 10.0
42 suppression of tumorigenicity 12 10.0
43 malaria 10.0
44 leukemia, acute lymphoblastic 10.0
45 beta-thalassemia 10.0
46 arteriovenous fistula 10.0
47 lymphoma 10.0
48 rabies 10.0
49 transitional cell carcinoma 10.0
50 protein c deficiency 10.0

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism
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Symptoms & Phenotypes for Priapism

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UMLS symptoms related to Priapism:


painful erection

MGI Mouse Phenotypes related to Priapism:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.08 AQP1 F13A1 F5 ITGAV KL NOS3
2 hematopoietic system MP:0005397 10.01 AQP1 F13A1 GNRH1 ITGAV KL NOS3
3 growth/size/body region MP:0005378 9.98 AQP1 F5 GNRH1 ITGAV KL NOS3
4 homeostasis/metabolism MP:0005376 9.97 AQP1 F13A1 F5 GNRH1 ITGAV KL
5 endocrine/exocrine gland MP:0005379 9.93 AQP1 F13A1 GNRH1 ITGAV KL NOS3
6 mortality/aging MP:0010768 9.86 AQP1 F13A1 F5 ITGAV KL NOS3
7 liver/biliary system MP:0005370 9.72 F5 GNRH1 KL NOS3 TGFBR3
8 muscle MP:0005369 9.55 ITGAV KL NOS3 SLC4A1 TGFBR3
9 renal/urinary system MP:0005367 9.43 AQP1 GNRH1 ITGAV KL NOS3 SLC4A1
10 reproductive system MP:0005389 9.1 AQP1 F13A1 GNRH1 KL NOS3 TGFBR3
Sources

Drugs & Therapeutics for Priapism

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Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
3 Anti-Infective Agents Phase 3,Phase 1,Phase 2
4 Adrenergic Antagonists Phase 3
5 Adrenergic alpha-1 Receptor Antagonists Phase 3
6 Neurotransmitter Agents Phase 3
7 Adrenergic alpha-Antagonists Phase 3
8 Adrenergic Agents Phase 3
9 Antihypertensive Agents Phase 3
10 Protective Agents Phase 3
11 Respiratory System Agents Phase 3
12 Free Radical Scavengers Phase 3
13 Expectorants Phase 3
14 N-monoacetylcystine Phase 3
15 Antidotes Phase 3
16 Antiviral Agents Phase 3
17 Antioxidants Phase 3
18
Hydroxyurea Approved Phase 1, Phase 2,Phase 2 127-07-1 3657
19
alemtuzumab Approved, Investigational Phase 1, Phase 2,Phase 2 216503-57-0
20
Everolimus Approved Phase 1, Phase 2,Phase 2 159351-69-6 70789204 6442177
21
Sirolimus Approved, Investigational Phase 1, Phase 2,Phase 2 53123-88-9 46835353 5284616 6436030
22
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Phase 2 22916-47-8 4189
23
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
24
Sodium Citrate Approved, Investigational Phase 2 68-04-2
25
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 2713 9552079
26
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
27
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
28 Immunologic Factors Phase 1, Phase 2,Phase 2
29 Antibiotics, Antitubercular Phase 1, Phase 2,Phase 2
30 Antifungal Agents Phase 1, Phase 2,Phase 2
31 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
32 Antineoplastic Agents, Immunological Phase 1, Phase 2,Phase 2
33 Anti-Bacterial Agents Phase 1, Phase 2,Phase 2
34 Antineoplastic Agents, Alkylating Phase 2
35 Trichostatin A Phase 2
36 Antirheumatic Agents Phase 2
37 Alkylating Agents Phase 2
38 Citrate Phase 2
39 Phosphodiesterase 5 Inhibitors Phase 2
40 Phosphodiesterase Inhibitors Phase 2
41 Sildenafil Citrate Phase 2 171599-83-0
42 Vasodilator Agents Phase 2
43 Immunoglobulins Phase 2
44 Antibodies, Monoclonal Phase 2
45 Antibodies Phase 2
46 Nucleic Acid Synthesis Inhibitors Phase 2
47 Disinfectants Phase 2
48 Analgesics Phase 2
49 Dermatologic Agents Phase 2
50 Anti-Infective Agents, Local Phase 2

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
2 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
3 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy Withdrawn NCT01560091 Phase 3 silodosin;Tamsulosin
4 Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) Unknown status NCT01499888 Phase 1, Phase 2 Alemtuzumab;Sirolimus
5 SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCD Unknown status NCT02013375 Phase 2 Alemtuzumab;Cyclophosphamide;Sirolimus
6 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
7 Intracavernous Bone Marrow Stem-cell Injection for Post Prostatectomy Erectile Dysfunction Completed NCT01089387 Phase 1, Phase 2
8 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
9 Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair & Same-Session Implantation Recruiting NCT03614429 Phase 2 Chlorhexidine gel will be prepared according to an international product Instillagel®
10 Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients Recruiting NCT03474965 Phase 2 Crizanlizumab
11 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Active, not recruiting NCT03264989 Phase 2 crizanlizumab
12 A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism Not yet recruiting NCT03938454 Phase 2 crizanlizumab
13 Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease Terminated NCT01987908 Phase 2 Aes-103
14 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
15 Sildenafil for Prevention of Cerebral Vasospasm Withdrawn NCT01091870 Phase 2 Placebo;Sildenafil Citrate, 25 mg, 3 times a day.;Sildenafil Citrate 50 mg, 3 times a day
16 Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence Completed NCT00300235
17 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Recruiting NCT02539771 Not Applicable
18 Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE Recruiting NCT03352986
19 Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose Recruiting NCT03114137
20 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

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Genetic Tests for Priapism

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Anatomical Context for Priapism

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MalaCards organs/tissues related to Priapism:

42
Myeloid, Kidney, Spinal Cord, Brain, Bone, Tongue, Bone Marrow
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Publications for Priapism

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Articles related to Priapism:

(show top 50) (show all 1525)
# Title Authors Year
1
Priapism following erector spinae plane block for the treatment of a complex regional pain syndrome. ( 30660341 )
2019
2
ISMP Adverse Drug Reactions: Longitudinal Thumbnail Fissures Due to Erlotinib Priapism Associated With the Use of ExtenZe Blindness From a Nevirapine-Based HAART Regimen Hyperprolactinemia and Galactorrhea Due to Aripiprazole Trypophobia Associated With Gabapentin Coadministered Linezolid and Methadone Cause Serotonin Syndrome. ( 30923400 )
2019
3
Priapism as a Debut Presentation of Chronic Myeloid Leukemia. ( 30630577 )
2019
4
Management of priapism with a trial of exercise in the emergency department. ( 29547365 )
2019
5
Unintended Consequences: A Review of Pharmacologically-Induced Priapism. ( 30503727 )
2019
6
The effects of oxytocin on penile tissues in experimental priapism model in rats. ( 30515737 )
2019
7
Immediate Placement of Penile Prosthesis for the Management of Ischemic Priapism as First-line Treatment. ( 30639251 )
2019
8
Re: Priapism throughout the Ages. ( 30664086 )
2019
9
Posttraumatic Arterial Priapism Treated with Superselective Embolization: Our Clinical Experience and a Review of the Literature. ( 30684137 )
2019
10
Ultrasound-Guided Dorsal Penile Neurolysis for Malignant Priapism Pain Management. ( 30686298 )
2019
11
Immediate Placement of a Penile Prosthesis as First-line Treatment for the Management of Ischaemic Priapism. ( 30691962 )
2019
12
Current practice in the management of ischemic priapism: an anonymous survey of ISSM members. ( 30718828 )
2019
13
Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade. ( 30719367 )
2019
14
Melanotan-induced priapism: a hard-earned tan. ( 30796078 )
2019
15
Comparison of outcomes in malignant vs. non-malignant ischemic priapism: 12-year experience from a tertiary center. ( 30817276 )
2019
16
Raising More Than Moods: Escitalopram-Associated Priapism. ( 30867630 )
2019
17
Management of Priapism: A Contemporary Review. ( 30898593 )
2019
18
A Systematic Review on Ischemic Priapism and Immediate Implantation: Do We Need More Data? ( 30898595 )
2019
19
Appropriate management of high-flow priapism based on color Doppler ultrasonography findings in pediatric patients: four case reports and a review of the literature. ( 30910454 )
2019
20
Ischemic priapism as a model of exhausted metabolism. ( 30916476 )
2019
21
Intractable acute ischaemic priapism occurring secondary to newly commenced olanzapine. ( 30936333 )
2019
22
Malignant priapism and germ cell tumour. ( 30942183 )
2019
23
Isolated glanular gangrene; a rare sequel of priapism. ( 30948408 )
2019
24
Management of stuttering priapism: a nonsystematic review. ( 30957473 )
2019
25
An Update on Non-Ischemic Priapism. ( 30987934 )
2019
26
Isolated intermittent neurogenic priapism: an unusual presentation in degenerative lumbar spinal stenosis. ( 30988105 )
2019
27
Which patients with ischaemic priapism require further investigation for malignancy? ( 30996267 )
2019
28
Malignant refractory priapism: An urologist's nightmare. ( 31040614 )
2019
29
Recurrent priapism in spinal cord injury: A case report. ( 31074709 )
2019
30
Benign High-Flow Priapism With a Diffuse and Intense 18F-FDG Uptake on 18F-FDG PET/CT Scanning. ( 31107751 )
2019
31
Priapism as the Presenting Complaint in Fatal Group A Streptococcal Induced Disseminated Intravascular Coagulation. ( 27989251 )
2018
32
The first case of neonatal priapism during hypothermia for hypoxic-ischemic encephalopathy and a literature review. ( 30053817 )
2018
33
Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression. ( 29110178 )
2018
34
Poorly Controlled Homocystinuria: A Rare Cause of Ischemic Priapism? ( 29463473 )
2018
35
Urologic Management of Priapism Secondary to Chronic Myeloid Leukemia. ( 30471371 )
2018
36
Priapism as a rare presentation of chronic myeloid leukemia. ( 30488874 )
2018
37
Combination High Flow Priapism With Low Flow Priapism: Case Report. ( 30522977 )
2018
38
Through Clinical Observation: The History of Priapism After Spinal Cord Injuries. ( 29054772 )
2018
39
Case report: ischemic priapism secondary to tinzaparin. ( 29222429 )
2018
40
Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism. ( 29278308 )
2018
41
Role of Penile Prosthesis in Priapism: A Review. ( 29299902 )
2018
42
BAUS consensus document for the management of male genital emergencies: priapism. ( 29357203 )
2018
43
Recent advances in the management of priapism. ( 29375820 )
2018
44
Molecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability. ( 29394072 )
2018
45
Case - Temporary chemical castration in the management of recurrent priapism. ( 29405906 )
2018
46
Priapism as the initial sign in hematologic disease: Case report and literature review. ( 29414500 )
2018
47
Prognosis of men with penile metastasis and malignant priapism: a systematic review. ( 29416825 )
2018
48
Superselective Transcatheter Artery Embolization in Patients with Non-ischemic Priapism. ( 29417263 )
2018
49
Penile Metastasis from Prostate Cancer Presenting as Malignant Priapism Detected Using Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography. ( 29430118 )
2018
50
Emergency Management of Priapism in the United Kingdom: A Survey of Current Practice. ( 29454716 )
2018
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Variations for Priapism

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Expression for Priapism

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Search GEO for disease gene expression data for Priapism.
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Pathways for Priapism

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Pathways related to Priapism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 67
Show member pathways
 12.63 F13A1 F5 ITGAV NOS3 PDE5A
2
Apoptosis Pathway 73
Show member pathways
 11.92 ITGAV NOS3 TGFBR3
3
Nitric oxide stimulates guanylate cyclase 67
Show member pathways
 10.99 NOS3 PDE5A
4
Erythrocytes take up carbon dioxide and release oxygen 67
Show member pathways
 10.8 AQP1 SLC4A1
5
Angiogenesis (CST) 4
10.75 ITGAV NOS3 TGFBR3
6
NO-dependent CFTR activation (normal and CF) 23
10.07 NOS3 PDE5A
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GO Terms for Priapism

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Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 AQP1 ITGAV KL SLC4A1 TGFBR3
2 platelet alpha granule lumen GO:0031093 8.96 F13A1 F5

Biological processes related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 9.26 F13A1 F5
2 bicarbonate transport GO:0015701 9.16 AQP1 SLC4A1
3 ventricular septum morphogenesis GO:0060412 8.96 NOS3 TGFBR3
4 response to prostaglandin E GO:0034695 8.62 GNRH1 TGFBR3

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.16 ITGAV TGFBR3
2 transforming growth factor beta binding GO:0050431 8.96 ITGAV TGFBR3
3 fibroblast growth factor binding GO:0017134 8.8 ITGAV KL TGFBR3
Sources

Sources for Priapism

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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