MCID: PRP007
MIFTS: 48

Priapism

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Priapism

MalaCards integrated aliases for Priapism:

Name: Priapism 12 52 54 43 15 71 32
Priapism, Familial Idiopathic 52 71
Familial Idiopathic Priapism 52
Mentulagra 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9286
ICD9CM 34 607.3
MeSH 43 D011317
NCIt 49 C85022
SNOMED-CT 67 4287008 6273006
ICD10 32 N48.3 N48.30
UMLS 71 C0033117 C1867771

Summaries for Priapism

Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to impotence and sexual disorder, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Calcium signaling pathway. The drugs Prazosin and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 impotence 31.1 PDE5A NOS3 NOS2 GNRH1 ADRA1A
2 sexual disorder 30.4 PDE5A NOS3 GNRH1 ADRA1A
3 peyronie disease 30.3 PDE5A NOS2
4 pulmonary embolism 30.3 PDE5A F5 F13A1
5 thalassemia 29.8 SLC4A1 HP HBB
6 pulmonary edema 29.8 NOS3 NOS2 HP
7 hemoglobin e disease 29.7 HBB F5
8 vascular disease 29.3 NOS3 NOS2 HP F5 F13A1
9 hereditary spherocytosis 29.0 SLC4A1 HP HBB AQP1
10 peritonitis 28.9 NOS2 AQP1 ADA
11 hemolytic anemia 28.8 SLC4A1 HP HBB ADA
12 low-flow priapism 12.6
13 priapism, familial idiopathic 12.3
14 persistent genital arousal disorder 11.6
15 sickle cell disease 10.9
16 stuttering 10.8
17 sickle cell anemia 10.7
18 leukemia 10.5
19 deficiency anemia 10.5
20 myeloid leukemia 10.5
21 acquired angioedema 10.4 HP F5
22 hemoglobinopathy 10.4
23 platelet membrane fluidity 10.3 NOS3 NOS2
24 bladder cancer 10.3
25 nonarteritic anterior ischemic optic neuropathy 10.3 PDE5A NOS3 F5
26 ureterolithiasis 10.3 PDE5A ADRA1A
27 chronic pulmonary heart disease 10.3 PDE5A NOS3 HP
28 compartment syndrome 10.3
29 transitional cell carcinoma 10.2
30 spinal cord injury 10.2
31 purpura 10.2
32 anoxia 10.2
33 thrombosis 10.2
34 spinal stenosis 10.2
35 48,xyyy 10.2
36 hydrarthrosis 10.1 MIP AQP1
37 attention deficit-hyperactivity disorder 10.1
38 peyronie's disease 10.1
39 pain agnosia 10.1
40 hypogonadism 10.1
41 hypogonadotropism 10.1
42 renal cell carcinoma, nonpapillary 10.1
43 myeloma, multiple 10.1
44 fabry disease 10.1
45 lymphocytic leukemia 10.1
46 glucosephosphate dehydrogenase deficiency 10.1
47 adenocarcinoma 10.1
48 schizoaffective disorder 10.1
49 dysferlinopathy 10.1 MIP AQP1
50 varicocele 10.1 NOS3 NOS2 GNRH1

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

MGI Mouse Phenotypes related to Priapism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 ADA ADORA2B ADRA1A AQP1 F13A1 F5
2 homeostasis/metabolism MP:0005376 10.22 ADA ADORA2B ADRA1A AQP1 F13A1 F5
3 hematopoietic system MP:0005397 10.21 ADA ADORA2B AQP1 F13A1 GNRH1 HP
4 immune system MP:0005387 10.07 ADA ADORA2B GNRH1 HP ITGAV KL
5 mortality/aging MP:0010768 10.07 ADA ADORA2B ADRA1A AQP1 F13A1 F5
6 liver/biliary system MP:0005370 9.92 ADA F5 GNRH1 HP KL NOS2
7 muscle MP:0005369 9.76 ADA ADRA1A ITGAV KL NOS2 NOS3
8 renal/urinary system MP:0005367 9.7 ADA ADORA2B ADRA1A AQP1 GNRH1 HP
9 reproductive system MP:0005389 9.28 ADA ADORA2B AQP1 F13A1 GNRH1 KL

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2 Immunologic Factors Phase 2, Phase 3
3 Antivenins Phase 2, Phase 3
4 Antihypertensive Agents Phase 3
5
Sodium citrate Approved, Investigational Phase 2 68-04-2
6
Hydroxyurea Approved Phase 2 127-07-1 3657
7
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
8
Polidocanol Approved Phase 2 9002-92-0
9
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
10 Sildenafil Citrate Phase 2 171599-83-0
11 Citrate Phase 2
12 Antibodies, Monoclonal Phase 2
13 Pharmaceutical Solutions Phase 2
14 Antibodies Phase 2
15 Immunoglobulins Phase 2
16 Dermatologic Agents Phase 2
17 Analgesics Phase 2
18 Chlorhexidine gluconate Phase 2
19 Disinfectants Phase 2
20 Anti-Infective Agents Phase 2
21 Anti-Infective Agents, Local Phase 2
22 Sclerosing Solutions Phase 2
23
Trazodone Approved, Investigational Phase 1 19794-93-5 5533
24
Macitentan Approved Phase 1 441798-33-0
25 Tranquilizing Agents Phase 1
26 Serotonin Uptake Inhibitors Phase 1
27 Psychotropic Drugs Phase 1
28 Serotonin Agents Phase 1
29 Antidepressive Agents Phase 1
30 Anti-Anxiety Agents Phase 1
31 Endothelin Receptor Antagonists Phase 1
32 Endothelin A Receptor Antagonists Phase 1
33
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
34
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
35
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
36
Carbon monoxide Approved, Investigational 630-08-0 281
37 Central Nervous System Depressants
38 Anesthetics, Local
39 Narcotics
40 Anesthetics
41 Adjuvants, Anesthesia
42 Anesthetics, General
43 Anesthetics, Intravenous
44 Analgesics, Opioid
45 Antimetabolites

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study Completed NCT01336660 Phase 2, Phase 3
2 Comparative Study of Efficacy of Antiscorpion Venom Serum(AScVS)vs Prazosin in the Management of Severe Scorpion(Mesobuthus Tamulus Concanesis Pocock)Envenomation and Evaluation of Effects of the Combination of AScVS + Prazosin Therapy. Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
3 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After ESWL Withdrawn NCT01560091 Phase 3 silodosin;Tamsulosin
4 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
5 A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Blind, 12-Month Study to Assess Safety and Efficacy of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Sickle Cell-Related Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
6 A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (Crizanlizumab), in Sickle Cell Disease Patients With Priapism (SPARTAN) Recruiting NCT03938454 Phase 2 crizanlizumab
7 Management of Urethral Injury During Penile Prosthesis Implantation: Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair and Same-Session Implantation Recruiting NCT03614429 Phase 2 Chlorhexidine gel will be prepared according to an international product Instillagel®
8 Sclerotherapy With Polidocanol Foam Versus Rubber Band Ligation in the Treatment of First, Second and Third-Grade Hemorrhoidal Disease: a Randomized, Controlled Trial Recruiting NCT04091763 Phase 2 Polidocanol Injectable Foam
9 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
10 Randomized Controlled Trial of Trazodone Dose Tolerance and APAP Adherence Unknown status NCT02945644 Phase 1 Trazodone;Placebo
11 The Safety and Efficacy of Macitentan for Treatment of Pulmonary Hypertension in Sickle Cell Disease Enrolling by invitation NCT02651272 Phase 1 macitentan
12 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Unknown status NCT02539771
13 The Epidemiology of Priapism (Sickle Cell Disease) Completed NCT00300235
14 Continuous Epidural Fentanyl Infusion Step-down Tapering Dose; Sole Intraoperative Analgesic Modality for Precious Single Kidney Patient. Completed NCT03606902 Group F: Continous epidural infusion of bupivacaine plus fentanyl;Group LF :Continous epidural infusion of decreasing doses of fentanyl plus pubivacaine
15 End-Alveolar Carbon Monoxide as a Measure of Erythrocyte Survival and Hemolytic Severity in Sickle Cell Disease Completed NCT01547793
16 The Association of Biomarkers of Endothelial Function With Prospective Changes in Kidney Function in Sickle Cell Anemia Recruiting NCT03277547
17 Hemoglobin Desaturation and RBC Adhesion: Potential Therapeutic Targets in Sickle Cell Disease Recruiting NCT03908385
18 A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises Terminated NCT02698761
19 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

MalaCards organs/tissues related to Priapism:

40
Myeloid, Prostate, Spinal Cord, Kidney, Smooth Muscle, Testes, Endothelial

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 2645)
# Title Authors PMID Year
1
Phosphodiesterase type 5 regulation in the penile corpora cavernosa. 61 54
19267844 2009
2
Sickle cell trait and priapism: a case report and review of the literature. 61 54
19116025 2008
3
Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism? 61 54
17971109 2008
4
Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health. 61 54
17942972 2008
5
Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. 54 61
17100941 2006
6
Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism. 54 61
16698365 2006
7
Tissue expression, distribution, and regulation of PDE5. 61 54
15224128 2004
8
Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. 61 54
12853767 2003
9
Chronic recurrent priapism: A high flow state secondary to an arteriovenous fistula of the corpus cavernosum. 61
31754604 2020
10
[Priapism as first clinical manifestation of chronic myeloid leucosis]. 61
31808643 2019
11
Penile Blood Gas Sample to Assess Recurrent Priapism. 61
31776164 2019
12
Clinical and laboratory parameters, risk factors predisposing to the development of priapism in sickle cell patients. 61
31810382 2019
13
Embolization of high-flow priapism: technical aspects and clinical outcome from a single-center experience. 61
31823294 2019
14
Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study. 61
31668730 2019
15
Re: Selective Penile Arterial Embolization Preserves Long-Term Erectile Function in Patients with Nonischemic Priapism: An 18-Year Experience. 61
31710560 2019
16
Paliperidone-Associated Priapism in an Autistic Child. 61
31703010 2019
17
Perspectives on Priapism Education in Emergency Medicine. 61
31735620 2019
18
Psychotropic-Induced Priapism in a Treatment-Refractory Patient: A Case Report. 61
31694449 2019
19
MRI of the penis. 61
31701192 2019
20
Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis. 61
30686687 2019
21
Neurofibromatosis-1 and Rhabdomyosarcoma: An Unusual Recurrence. 61
31794814 2019
22
Priapism, hemoglobin desaturation, and red blood cell adhesion in men with sickle cell anemia. 61
31404907 2019
23
Two-piece inflatable and semi-rigid penile implants: an effective alternative? 61
31685942 2019
24
Fundamentals of prosthetic urology. 61
31696834 2019
25
Current practice in the management of ischemic priapism: an anonymous survey of ISSM members. 61
30718828 2019
26
Priapism secondary to chronic myeloid leukemia treated by a surgical cavernosa-corpus spongiosum shunt: Case report. 61
31768325 2019
27
Priapism from Recreational Intracavernosal Injections in a High-Risk Metropolitan Community. 61
31501058 2019
28
Priapism induced by use of tamsulosin: A case report and review of the literature. 61
31577106 2019
29
Post-traumatic high-flow priapism: uncommon presentation with endovascular management. 61
31645391 2019
30
An update on the drug safety of treating erectile dysfunction. 61
31433252 2019
31
Identification and Characterization of Hematopoietic Stem Cell Transplant Candidates in a Sickle Cell Disease Cohort. 61
31229639 2019
32
Catastrophic Antiphospholipid Syndrome Presenting with Genitourinary Manifestations. 61
31816208 2019
33
Predictors for Mortality in Children with Scorpion Envenomation Admitted to Pediatric Intensive Care Unit, Qena Governorate, Egypt. 61
31407657 2019
34
Re: Current Practice in the Management of Ischemic Priapism: An Anonymous Survey of ISSM Members. 61
31219373 2019
35
Resolution of Acute Priapism in Two Children With Sickle Cell Disease Who Received Nitrous Oxide. 61
31228879 2019
36
[Histologic Evaluation of Prolonged Ischemic Priapism Using Winter Procedure with Percutaneous Distal Shunt Construction-Report of Two Cases]. 61
31697882 2019
37
Long-term intracavernosal injection therapy: treatment efficacy and patient satisfaction. 61
31477852 2019
38
Priapism With Methylphenidate Use in a Preschool-Aged Boy Resolved With Switching to Atomoxetine. 61
31361667 2019
39
Penile metastasis from recurrent sarcoma in a teenager: a case report. 61
31477090 2019
40
The surgical management of ischaemic priapism. 61
31570823 2019
41
Imaging appearance and role of CEUS of high flow priapism. A case report. 61
31476217 2019
42
Anatomic and Functional Outcome Following Distal Shunt and Tunneling for Treatment ─░schemic Priapism: A Single-Center Experience. 61
31230939 2019
43
Erectile dysfunction management after failed phosphodiesterase-5-inhibitor trial: a cost-effectiveness analysis. 61
31555563 2019
44
Clinical features of rabies patients with abnormal sexual behaviors as the presenting manifestations: a case report and literature review. 61
31370800 2019
45
Immediate Placement of Penile Prosthesis for the Management of Ischemic Priapism as First-line Treatment. 61
30639251 2019
46
Priapism induced by various psychotropics: A case series. 61
30208753 2019
47
Metastatic plasmacytoid bladder cancer causing malignant priapism. 61
31266754 2019
48
Synchronous Urethral Repair During Prosthetic Surgery: Safety of Planned and Damage Control Approaches Using Suprapubic Tube Urinary Diversion. 61
30962156 2019
49
[Ischemic Priapism Associated with Essential Thrombocythemia : A Case Report]. 61
31501399 2019
50
Benign High-Flow Priapism With a Diffuse and Intense 18F-FDG Uptake on 18F-FDG PET/CT Scanning. 61
31107751 2019

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.15 TGFBR3 SLC4A1 NOS3 NOS2 MIP KL
2 extracellular space GO:0005615 9.86 TGFBR3 OPRPN KL HP HBB GNRH1
3 extracellular region GO:0005576 9.81 TGFBR3 SMR3A OPRPN KL HP HBB
4 integral component of plasma membrane GO:0005887 9.56 TGFBR3 SLC4A1 MIP KL ITGAV AQP1
5 endocytic vesicle lumen GO:0071682 9.4 HP HBB
6 haptoglobin-hemoglobin complex GO:0031838 9.32 HP HBB
7 blood microparticle GO:0072562 8.92 SLC4A1 HP HBB F13A1

Biological processes related to Priapism according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.67 SLC4A1 HBB F5 F13A1
2 response to hormone GO:0009725 9.58 NOS3 NOS2 ADRA1A
3 aging GO:0007568 9.56 KL GNRH1 ADRA1A ADA
4 positive regulation of heart rate GO:0010460 9.54 ADRA1A ADA
5 positive regulation of smooth muscle contraction GO:0045987 9.52 ADRA1A ADA
6 nitric oxide mediated signal transduction GO:0007263 9.51 NOS3 NOS2
7 response to hydrogen peroxide GO:0042542 9.5 HP HBB ADA
8 water transport GO:0006833 9.49 MIP AQP1
9 nitric oxide biosynthetic process GO:0006809 9.48 NOS3 NOS2
10 response to prostaglandin E GO:0034695 9.46 TGFBR3 GNRH1
11 arginine catabolic process GO:0006527 9.43 NOS3 NOS2
12 bicarbonate transport GO:0015701 9.33 SLC4A1 HBB AQP1
13 nitric oxide transport GO:0030185 8.96 HBB AQP1
14 positive regulation of guanylate cyclase activity GO:0031284 8.8 NOS3 NOS2 ADORA2B

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.46 TGFBR3 ITGAV
2 FMN binding GO:0010181 9.43 NOS3 NOS2
3 water channel activity GO:0015250 9.4 MIP AQP1
4 arginine binding GO:0034618 9.37 NOS3 NOS2
5 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS3 NOS2
6 tetrahydrobiopterin binding GO:0034617 9.26 NOS3 NOS2
7 nitric-oxide synthase activity GO:0004517 9.16 NOS3 NOS2
8 fibroblast growth factor binding GO:0017134 9.13 TGFBR3 KL ITGAV
9 hemoglobin binding GO:0030492 8.8 SLC4A1 HP HBB

Sources for Priapism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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