MCID: PRP007
MIFTS: 47

Priapism

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Priapism

MalaCards integrated aliases for Priapism:

Name: Priapism 12 52 54 43 15 71 32
Priapism, Familial Idiopathic 52 71
Familial Idiopathic Priapism 52
Mentulagra 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9286
ICD9CM 34 607.3
MeSH 43 D011317
NCIt 49 C85022
SNOMED-CT 67 6273006
ICD10 32 N48.3
UMLS 71 C0033117 C1867771

Summaries for Priapism

Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to impotence and sexual disorder, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Calcium signaling pathway. The drugs Prazosin and Antivenins have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 impotence 31.1 PDE5A NOS3 NOS2 GNRH1 ADRA1A
2 sexual disorder 30.4 PDE5A NOS3 GNRH1 ADRA1A
3 pulmonary embolism 30.3 PDE5A F5 F13A1
4 peyronie disease 30.1 PDE5A NOS2
5 pulmonary edema 29.8 NOS3 NOS2 HP
6 thalassemia 29.8 SLC4A1 HP HBB
7 vascular disease 29.3 NOS3 NOS2 HP F5 F13A1
8 hereditary spherocytosis 29.0 SLC4A1 HP HBB AQP1
9 peritonitis 28.9 NOS2 AQP1 ADA
10 hemolytic anemia 28.9 SLC4A1 HP HBB ADA
11 congenital hemolytic anemia 28.4 SLC4A1 HP HBB ADA
12 low-flow priapism 12.6
13 priapism, familial idiopathic 12.3
14 persistent genital arousal disorder 11.6
15 sickle cell disease 10.9
16 stuttering 10.8
17 sickle cell anemia 10.7
18 myeloid leukemia 10.6
19 leukemia 10.5
20 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.5
21 deficiency anemia 10.5
22 leukemia, chronic myeloid 10.5
23 acquired angioedema 10.4 HP F5
24 hemoglobinopathy 10.4
25 ureterolithiasis 10.3 PDE5A ADRA1A
26 platelet membrane fluidity 10.3 NOS3 NOS2
27 bladder cancer 10.3
28 nonarteritic anterior ischemic optic neuropathy 10.3 PDE5A NOS3 F5
29 pyometritis 10.3 HP GNRH1
30 chronic pulmonary heart disease 10.3 PDE5A NOS3 HP
31 compartment syndrome 10.3
32 transitional cell carcinoma 10.2
33 spinal cord injury 10.2
34 purpura 10.2
35 spinal stenosis 10.2
36 anoxia 10.2
37 attention deficit-hyperactivity disorder 10.2
38 thrombosis 10.2
39 48,xyyy 10.2
40 anemia, congenital dyserythropoietic, type ib 10.2 HP AQP1
41 leukemia, acute lymphoblastic 10.2
42 peyronie's disease 10.2
43 pain agnosia 10.2
44 hypogonadism 10.2
45 hydrarthrosis 10.1 MIP AQP1
46 renal cell carcinoma, nonpapillary 10.1
47 myeloma, multiple 10.1
48 fabry disease 10.1
49 glucosephosphate dehydrogenase deficiency 10.1
50 adenocarcinoma 10.1

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

GenomeRNAi Phenotypes related to Priapism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-2 9.58 ITGAV
2 Decreased viability GR00249-S 9.58 F13A1 F5 HP ITGAV MIP NOS3
3 Decreased viability GR00381-A-1 9.58 ADRA1A AQP1 ITGAV
4 Decreased viability GR00386-A-1 9.58 ITGAV KL NOS3 OPRPN
5 Decreased viability GR00402-S-2 9.58 ADORA2B ADRA1A AQP1

MGI Mouse Phenotypes related to Priapism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 ADA ADORA2B ADRA1A AQP1 F13A1 F5
2 homeostasis/metabolism MP:0005376 10.22 ADA ADORA2B ADRA1A AQP1 F13A1 F5
3 hematopoietic system MP:0005397 10.21 ADA ADORA2B AQP1 F13A1 GNRH1 HP
4 immune system MP:0005387 10.07 ADA ADORA2B GNRH1 HP ITGAV KL
5 mortality/aging MP:0010768 10.07 ADA ADORA2B ADRA1A AQP1 F13A1 F5
6 liver/biliary system MP:0005370 9.92 ADA F5 GNRH1 HP KL NOS2
7 muscle MP:0005369 9.76 ADA ADRA1A ITGAV KL NOS2 NOS3
8 renal/urinary system MP:0005367 9.7 ADA ADORA2B ADRA1A AQP1 GNRH1 HP
9 reproductive system MP:0005389 9.28 ADA ADORA2B AQP1 F13A1 GNRH1 KL

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2 Antivenins Phase 2, Phase 3
3 Immunologic Factors Phase 2, Phase 3
4 Antihypertensive Agents Phase 3
5
Sodium citrate Approved, Investigational Phase 2 68-04-2
6
Hydroxyurea Approved Phase 2 127-07-1 3657
7
Macitentan Approved Phase 2 441798-33-0
8
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
9
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 9552079 2713
10
Polidocanol Approved Phase 2 9002-92-0
11
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
12 Citrate Phase 2
13 Sildenafil Citrate Phase 2 171599-83-0
14 Endothelin A Receptor Antagonists Phase 2
15 Endothelin Receptor Antagonists Phase 2
16 Immunoglobulins Phase 2
17 Antibodies Phase 2
18 Pharmaceutical Solutions Phase 2
19 Antibodies, Monoclonal Phase 2
20 Analgesics Phase 2
21 Disinfectants Phase 2
22 Chlorhexidine gluconate Phase 2
23 Anti-Infective Agents, Local Phase 2
24 Anti-Infective Agents Phase 2
25 Sclerosing Solutions Phase 2
26
Trazodone Approved, Investigational Phase 1 19794-93-5 5533
27 Antidepressive Agents Phase 1
28 Anti-Anxiety Agents Phase 1
29 Psychotropic Drugs Phase 1
30 Serotonin Uptake Inhibitors Phase 1
31
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
32
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
33
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
34
Carbon monoxide Approved, Investigational 630-08-0 281
35 Narcotics
36 Anesthetics, General
37 Analgesics, Opioid
38 Anesthetics, Local
39 Anesthetics, Intravenous
40 Anesthetics

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study Completed NCT01336660 Phase 2, Phase 3
2 Comparative Study of Efficacy of Antiscorpion Venom Serum(AScVS)vs Prazosin in the Management of Severe Scorpion(Mesobuthus Tamulus Concanesis Pocock)Envenomation and Evaluation of Effects of the Combination of AScVS + Prazosin Therapy. Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
3 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After ESWL Withdrawn NCT01560091 Phase 3 silodosin;Tamsulosin
4 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
5 A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Blind, 12-Month Study to Assess Safety and Efficacy of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Sickle Cell-Related Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
6 The Safety and Efficacy of Macitentan for Treatment of Pulmonary Hypertension in Sickle Cell Disease Completed NCT02651272 Phase 2 macitentan
7 A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (Crizanlizumab), in Sickle Cell Disease Patients With Priapism (SPARTAN) Recruiting NCT03938454 Phase 2 crizanlizumab
8 Management of Urethral Injury During Penile Prosthesis Implantation: Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair and Same-Session Implantation Recruiting NCT03614429 Phase 2 Chlorhexidine gel will be prepared according to an international product Instillagel®
9 Sclerotherapy With Polidocanol Foam Versus Rubber Band Ligation in the Treatment of First, Second and Third-Grade Hemorrhoidal Disease: a Randomized, Controlled Trial Recruiting NCT04091763 Phase 2 Polidocanol Injectable Foam
10 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
11 Randomized Controlled Trial of Trazodone Dose Tolerance and APAP Adherence Suspended NCT02945644 Phase 1 Trazodone;Placebo
12 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Unknown status NCT02539771
13 The Epidemiology of Priapism (Sickle Cell Disease) Completed NCT00300235
14 Continuous Epidural Fentanyl Infusion Step-down Tapering Dose; Sole Intraoperative Analgesic Modality for Precious Single Kidney Patient. Completed NCT03606902 Group F: Continous epidural infusion of bupivacaine plus fentanyl;Group LF :Continous epidural infusion of decreasing doses of fentanyl plus pubivacaine
15 End-Alveolar Carbon Monoxide as a Measure of Erythrocyte Survival and Hemolytic Severity in Sickle Cell Disease Completed NCT01547793
16 The Association of Biomarkers of Endothelial Function With Prospective Changes in Kidney Function in Sickle Cell Anemia Recruiting NCT03277547
17 Hemoglobin Desaturation and RBC Adhesion: Potential Therapeutic Targets in Sickle Cell Disease Recruiting NCT03908385
18 A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises Terminated NCT02698761
19 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

MalaCards organs/tissues related to Priapism:

40
Myeloid, Prostate, Spinal Cord, Kidney, Smooth Muscle, Testes, Endothelial

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 2690)
# Title Authors PMID Year
1
Phosphodiesterase type 5 regulation in the penile corpora cavernosa. 54 61
19267844 2009
2
Sickle cell trait and priapism: a case report and review of the literature. 54 61
19116025 2008
3
Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health. 61 54
17942972 2008
4
Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism? 61 54
17971109 2008
5
Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. 61 54
17100941 2006
6
Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism. 61 54
16698365 2006
7
Tissue expression, distribution, and regulation of PDE5. 54 61
15224128 2004
8
Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. 61 54
12853767 2003
9
Sonography of the penis/erectile dysfunction. 61
32285181 2020
10
MRI of the penis. 61
31701192 2020
11
Re: Acute Ischemic Priapism Management: An Educational and Simulation Curriculum. 61
32159437 2020
12
Re: The Hemodynamic Effects of Intracavernosal Phenylephrine for the Treatment of Ischemic Priapism. 61
32159435 2020
13
Re: Penoscrotal Decompression-Promising New Treatment Paradigm for Refractory Ischemic Priapism. 61
32159436 2020
14
Using Artificial Intelligence to Predict Surgical Shunts in Men with Ischemic Priapism. 61
32516073 2020
15
Sickle cell disease as a vascular disorder. 61
32362160 2020
16
Favorable Multi-Institutional Experience with Penoscrotal Decompression for Prolonged Ischemic Priapism. 61
32501654 2020
17
Abdominal Manifestations of Sickle Cell Disease. 61
32564896 2020
18
Mechanisms underlying priapism in sickle cell disease: targeting and key innovations on the preclinical landscape. 61
32191546 2020
19
Priapism Associated With Cabergoline In A Young Adult. 61
32402771 2020
20
Stingray spear injury to the pediatric spinal cord: case report and review of the literature. 61
32361931 2020
21
Long-term intracavernosal injection therapy: treatment efficacy and patient satisfaction. 61
31477852 2020
22
Independent Predictive Factors for Occurrence of Ischemic Priapism after Papaverine Injection. 61
32478401 2020
23
Successful Management of Methylphenidate or Atomoxetine-Related Priapism During Attention-Deficit Hyperactivity Disorder Treatment. 61
32332473 2020
24
High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia. 61
32140892 2020
25
A case of proximal partial priapism successfully treated with autologous clot embolisation. 61
31965580 2020
26
Priapism associated with pregabalin. 61
31883652 2020
27
Microsurgical Phalloplasty in Nontranssexual Patients - Considerations After a Retrospective Single-center Analysis of 23 Cases. 61
32283166 2020
28
Cylinder insertion into scarred corporal bodies: prosthetic urology's most difficult challenge: some suggestions for making the surgery easier. 61
32313089 2020
29
[Medicaments and oral healthcare. Hyperpigmentation of oral soft tissues due to afamelanotide]. 61
32459219 2020
30
Overview of paediatric urology practice in lagos state university teaching hospital, Ikeja, Lagos, Nigeria. 61
32295945 2020
31
Sickle cell disease clinical phenotypes in Nigeria: A preliminary analysis of the Sickle Pan Africa Research Consortium Nigeria database. 61
32504882 2020
32
The management of stuttering priapism. 61
30957473 2020
33
Priapism in a 28-year-old Male with Bipolar Disorder. 61
32431999 2020
34
Treatments for priapism in boys and men with sickle cell disease. 61
32251534 2020
35
Possible Propofol-Induced Priapism Following Cardiac Catheter Ablation in a Teenager. 61
32248201 2020
36
Embolization of high-flow priapism: technical aspects and clinical outcome from a single-center experience. 61
31823294 2020
37
High-flow post-traumatic priapism: diagnostic and therapeutic workup. 61
32198630 2020
38
The effect of an antifibrotic agent, pirfenidone, on penile erectile function in an experimental rat model of ischemic priapism. 61
31186550 2020
39
Malignant priapismus induced by adenocarcinoma of the prostate. 61
31890603 2020
40
Neurofibromatosis-1 and Rhabdomyosarcoma: An Unusual Recurrence. 61
31794814 2020
41
PSMA-PET/CT-avid metastatic prostate cancer to the penis. 61
32209576 2020
42
Which patients with ischaemic priapism require further investigation for malignancy? 61
30996267 2020
43
Re: Selective Penile Arterial Embolization Preserves Long-Term Erectile Function in Patients with Nonischemic Priapism: An 18-Year Experience. 61
31710560 2020
44
Corpus Cavernosum Abscess Secondary to Traumatic Perforation of Urethral Diverticulum. 61
32211265 2020
45
Long-term sequelae of inflatable penile prosthesis: clinical characteristics of patients who develop distal cylinder tip extrusion. 61
32055464 2020
46
Dutasteride in the long-term management of stuttering priapism. 61
32055472 2020
47
High-flow priapism treated with selective embolization of a helicine branch of the penile artery: A case report and selected review of the literature. 61
32015631 2020
48
Prevalence of priapism in individuals with sickle cell disease and implications on male sexual function. 61
32321079 2020
49
Clinical and laboratory parameters, risk factors predisposing to the development of priapism in sickle cell patients. 61
31810382 2020
50
Perspectives on Priapism Education in Emergency Medicine. 61
31735620 2020

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.15 TGFBR3 SLC4A1 NOS3 NOS2 MIP KL
2 cell GO:0005623 9.91 SLC4A1 NOS3 NOS2 ITGAV AQP1 ADRA1A
3 extracellular space GO:0005615 9.86 TGFBR3 OPRPN KL HP HBB GNRH1
4 extracellular region GO:0005576 9.81 TGFBR3 SMR3A OPRPN KL HP HBB
5 endocytic vesicle lumen GO:0071682 9.4 HP HBB
6 haptoglobin-hemoglobin complex GO:0031838 9.32 HP HBB
7 blood microparticle GO:0072562 9.26 SLC4A1 HP HBB F13A1
8 integral component of plasma membrane GO:0005887 9.23 TGFBR3 SLC4A1 MIP KL ITGAV AQP1

Biological processes related to Priapism according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.71 SLC4A1 HBB F5 F13A1
2 aging GO:0007568 9.56 KL GNRH1 ADRA1A ADA
3 positive regulation of heart rate GO:0010460 9.55 ADRA1A ADA
4 positive regulation of smooth muscle contraction GO:0045987 9.54 ADRA1A ADA
5 response to hormone GO:0009725 9.54 NOS3 NOS2 ADRA1A
6 nitric oxide mediated signal transduction GO:0007263 9.52 NOS3 NOS2
7 water transport GO:0006833 9.51 MIP AQP1
8 response to hydrogen peroxide GO:0042542 9.5 HP HBB ADA
9 nitric oxide biosynthetic process GO:0006809 9.49 NOS3 NOS2
10 response to prostaglandin E GO:0034695 9.48 TGFBR3 GNRH1
11 negative regulation of oxidoreductase activity GO:0051354 9.46 SLC4A1 HP
12 arginine catabolic process GO:0006527 9.43 NOS3 NOS2
13 bicarbonate transport GO:0015701 9.33 SLC4A1 HBB AQP1
14 nitric oxide transport GO:0030185 8.96 HBB AQP1
15 positive regulation of guanylate cyclase activity GO:0031284 8.8 NOS3 NOS2 ADORA2B

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.46 NOS3 NOS2
2 FMN binding GO:0010181 9.43 NOS3 NOS2
3 water channel activity GO:0015250 9.4 MIP AQP1
4 arginine binding GO:0034618 9.37 NOS3 NOS2
5 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS3 NOS2
6 tetrahydrobiopterin binding GO:0034617 9.26 NOS3 NOS2
7 nitric-oxide synthase activity GO:0004517 9.16 NOS3 NOS2
8 fibroblast growth factor binding GO:0017134 9.13 TGFBR3 KL ITGAV
9 hemoglobin binding GO:0030492 8.8 SLC4A1 HP HBB

Sources for Priapism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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