MCID: PRM004
MIFTS: 33

Primary Amebic Meningoencephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Primary Amebic Meningoencephalitis

MalaCards integrated aliases for Primary Amebic Meningoencephalitis:

Name: Primary Amebic Meningoencephalitis 12 54 3 15 74
Pam 54 3
Meningoencephalitis Caused by Naegleria Fowleri 54
Primary Amoebic Meningoencephalitis 54
Naegleria Fowleri Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050242
UMLS 74 C0300934

Summaries for Primary Amebic Meningoencephalitis

CDC : 3 Naegleria fowleri (commonly referred to as the “brain-eating amoeba” or “brain-eating ameba”), is a free-living microscopic ameba*, (single-celled living organism). It can cause a rare** and devastating infection of the brain called primary amebic meningoencephalitis (PAM). The ameba is commonly found in warm freshwater (e.g. lakes, rivers, and hot springs) and soil. Naegleria fowleri usually infects people when contaminated water enters the body through the nose. Once the ameba enters the nose, it travels to the brain where it causes PAM, which is usually fatal. Infection typically occurs when people go swimming or diving in warm freshwater places, like lakes and rivers. In very rare instances, Naegleria infections may also occur when contaminated water from other sources (such as inadequately chlorinated swimming pool water or heated and contaminated tap water) enters the nose 1-4. You cannot get infected from swallowing water contaminated with Naegleria.

MalaCards based summary : Primary Amebic Meningoencephalitis, also known as pam, is related to pulmonary alveolar microlithiasis and amoebiasis due to free-living amoebae. An important gene associated with Primary Amebic Meningoencephalitis is KCNH6 (Potassium Voltage-Gated Channel Subfamily H Member 6), and among its related pathways/superpathways are Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics and Effects of Nitric Oxide. Affiliated tissues include brain, testes and pituitary.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

Wikipedia : 77 Naegleriasis (also known as primary amoebic meningoencephalitis) is an infection of the brain by the... more...

Related Diseases for Primary Amebic Meningoencephalitis

Diseases related to Primary Amebic Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 pulmonary alveolar microlithiasis 11.4
2 amoebiasis due to free-living amoebae 11.4
3 meningoencephalitis 11.0
4 headache 10.2
5 systemic lupus erythematosus 10.0
6 lupus erythematosus 10.0
7 meningitis 10.0
8 pneumococcal meningitis 10.0
9 hereditary xanthinuria 9.7 AOX1 XDH
10 xanthinuria 9.7 AOX1 XDH
11 xanthinuria, type i 9.7 AOX1 XDH
12 xanthinuria, type ii 9.6 AOX1 XDH
13 purine-pyrimidine metabolic disorder 9.6 AOX1 XDH
14 molybdenum cofactor deficiency 9.4 AOX1 XDH

Graphical network of the top 20 diseases related to Primary Amebic Meningoencephalitis:



Diseases related to Primary Amebic Meningoencephalitis

Symptoms & Phenotypes for Primary Amebic Meningoencephalitis

Drugs & Therapeutics for Primary Amebic Meningoencephalitis

Search Clinical Trials , NIH Clinical Center for Primary Amebic Meningoencephalitis

Genetic Tests for Primary Amebic Meningoencephalitis

Anatomical Context for Primary Amebic Meningoencephalitis

MalaCards organs/tissues related to Primary Amebic Meningoencephalitis:

42
Brain, Testes, Pituitary, T Cells, Skin, Pancreas, Monocytes

Publications for Primary Amebic Meningoencephalitis

Articles related to Primary Amebic Meningoencephalitis:

(show top 50) (show all 752)
# Title Authors Year
1
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures. ( 30109815 )
2019
2
A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells. ( 30317586 )
2019
3
Genome editing in plants by engineered CRISPR-Cas9 recognizing NG PAM. ( 30531939 )
2019
4
Effective treatment of reverse osmosis concentrate from incineration leachate using direct contact membrane distillation coupled with a NaOH/PAM pre-treatment process. ( 30583212 )
2019
5
C-band PAM-4 signal transmission using soft-output MLSE and LDPC code. ( 30645352 )
2019
6
Amplifierless PAM-4/PAM-8 transmissions in O-band using a directly modulated laser for optical data-center interconnects. ( 30645541 )
2019
7
PAM/GO/gel/SA composite hydrogel conduit with bioactivity for repairing peripheral nerve injury. ( 30706639 )
2019
8
Microwave assisted synthesis of polyacrylamide grafted polymeric blend of fenugreek seed mucilage-Polyvinyl alcohol (FSM-PVA-g-PAM) and its characterizations as tissue engineered scaffold and as a drug delivery device. ( 30712231 )
2019
9
Engineer chimeric Cas9 to expand PAM recognition based on evolutionary information. ( 30718489 )
2019
10
Systematic analysis of Type I-E Escherichia coli CRISPR-Cas PAM sequences ability to promote interference and primed adaptation. ( 30875129 )
2019
11
100 Gbit/s VSB-PAM-n IM/DD transmission system based on 10 GHz DML with optical filtering and joint nonlinear equalization. ( 30876203 )
2019
12
Memory-controlled deep LSTM neural network post-equalizer used in high-speed PAM VLC system. ( 30876338 )
2019
13
Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen. ( 30880082 )
2019
14
Construction of non-canonical PAM-targeting adenosine base editors by restriction enzyme-free DNA cloning using CRISPR-Cas9. ( 30894632 )
2019
15
Genome Engineering in Rice Using Cas9 Variants that Recognize NG PAM Sequences. ( 30928636 )
2019
16
Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG. ( 30928637 )
2019
17
Cas4-Cas1 fusions drive efficient PAM selection and control CRISPR adaptation. ( 30937444 )
2019
18
High temperature utilization of PAM and HPAM by microbial communities enriched from oilfield produced water and activated sludge. ( 30968201 )
2019
19
Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9. ( 31036811 )
2019
20
DAC-less PAM-4 generation in the O-band using a silicon Mach-Zehnder modulator. ( 31045123 )
2019
21
Plant genome editing using xCas9 with expanded PAM compatibility. ( 31054950 )
2019
22
Engineered xCas9 and SpCas9-NG variants broaden PAM recognition sites to generate mutations in Arabidopsis plants. ( 31070861 )
2019
23
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach. ( 31074292 )
2019
24
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. ( 31110355 )
2019
25
PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma. ( 29844863 )
2018
26
Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States1. ( 29260676 )
2018
27
Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation. ( 29401275 )
2018
28
Nurse's guide to primary amebic meningoencephalitis. ( 29561369 )
2018
29
Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China. ( 29751112 )
2018
30
Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in the Hartley guinea pig. ( 30056178 )
2018
31
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154. ( 28729220 )
2018
32
Targeting Protective Catalase of Tumor Cells with Cold Atmospheric Plasma- Activated Medium (PAM). ( 28762315 )
2018
33
Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis. ( 29230717 )
2018
34
Plasma-activated medium (PAM) kills human cancer-initiating cells. ( 29235204 )
2018
35
SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells. ( 29247600 )
2018
36
Adaptation and validation of the German Patient Activation Measure for adolescents with chronic conditions in transitional care: PAM® 13 for Adolescents. ( 29266283 )
2018
37
Correction to: Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis. ( 29299760 )
2018
38
Effect of SLC34A2 gene mutation on extracellular phosphorus transport in PAM alveolar epithelial cells. ( 29375690 )
2018
39
Underwater wireless optical communication using an arrayed transmitter/receiver and optical superimposition-based PAM-4 signal. ( 29401841 )
2018
40
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. ( 29512652 )
2018
41
Silicon photonic dual-drive MIM based 56 Gb/s DAC-less and DSP-free PAM-4 transmission. ( 29529742 )
2018
42
Low-cost and miniaturized 100-Gb/s (2 × 50 Gb/s) PAM-4 TO-packaged ROSA for data center networks. ( 29529810 )
2018
43
SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells. ( 29544034 )
2018
44
Plant Genome Editing Using FnCpf1 and LbCpf1 Nucleases at Redefined and Altered PAM Sites. ( 29567452 )
2018
45
Cas4 Facilitates PAM-Compatible Spacer Selection during CRISPR Adaptation. ( 29590607 )
2018
46
Digital chromatic dispersion pre-management enabled single-lane 112  Gb/s PAM-4 signal transmission over 80  km SSMF. ( 29601013 )
2018
47
Optical single side-band Nyquist PAM-4 transmission using dual-drive MZM modulation and direct detection. ( 29609350 )
2018
48
Cousin Pam. ( 29617584 )
2018
49
PAM: A Framework for Integrated Analysis of Imaging, Single-Molecule, and Ensemble Fluorescence Data. ( 29642023 )
2018
50
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity. ( 29701957 )
2018

Variations for Primary Amebic Meningoencephalitis

Expression for Primary Amebic Meningoencephalitis

Search GEO for disease gene expression data for Primary Amebic Meningoencephalitis.

Pathways for Primary Amebic Meningoencephalitis

Pathways related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.39 AOX1 XDH
2 9.53 AOX1 XDH

GO Terms for Primary Amebic Meningoencephalitis

Biological processes related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transport chain GO:0022900 8.96 AOX1 XDH
2 xanthine catabolic process GO:0009115 8.62 AOX1 XDH

Molecular functions related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.43 AOX1 XDH
2 electron transfer activity GO:0009055 9.4 AOX1 XDH
3 flavin adenine dinucleotide binding GO:0050660 9.37 AOX1 XDH
4 iron-sulfur cluster binding GO:0051536 9.32 AOX1 XDH
5 FAD binding GO:0071949 9.26 AOX1 XDH
6 2 iron, 2 sulfur cluster binding GO:0051537 9.16 AOX1 XDH
7 molybdopterin cofactor binding GO:0043546 8.96 AOX1 XDH
8 xanthine dehydrogenase activity GO:0004854 8.62 AOX1 XDH

Sources for Primary Amebic Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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