MCID: PRM004
MIFTS: 38

Primary Amebic Meningoencephalitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Primary Amebic Meningoencephalitis

MalaCards integrated aliases for Primary Amebic Meningoencephalitis:

Name: Primary Amebic Meningoencephalitis 12 53 3 15 73
Pam 53 3
Meningoencephalitis Caused by Naegleria Fowleri 53
Primary Amoebic Meningoencephalitis 53
Naegleria Fowleri Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050242
UMLS 73 C0300934

Summaries for Primary Amebic Meningoencephalitis

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

MalaCards based summary : Primary Amebic Meningoencephalitis, also known as pam, is related to amoebiasis due to free-living amoebae and meningoencephalitis. An important gene associated with Primary Amebic Meningoencephalitis is C9 (Complement C9), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include brain, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

CDC : 3 Get Email Updates

Related Diseases for Primary Amebic Meningoencephalitis

Diseases related to Primary Amebic Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 amoebiasis due to free-living amoebae 11.2
2 meningoencephalitis 10.9
3 panophthalmitis 10.7 CD79A CTSL
4 chronic follicular conjunctivitis 10.6 CD79A IL1B
5 penicillin allergy 10.5 IL4 STAT6
6 jak3-deficient severe combined immunodeficiency 10.5 IL4 STAT6
7 immunoglobulin a deficiency 1 10.5 CD79A IL4
8 baylisascariasis 10.5 GAPDH IL4
9 cow milk allergy 10.5 CD79A IL5
10 congenital hypogammaglobulinemia 10.4 CD79A IL4
11 cough variant asthma 10.4 IL4 IL5
12 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 IL6
13 diversion colitis 10.4 IL1B IL4
14 egg allergy 10.4 IL4 IL5
15 parasitic ichthyosporea infectious disease 10.4 CD79A IL4
16 polyclonal hypergammaglobulinemia 10.4 CD79A IL6
17 recurrent corneal erosion 10.4 IL1B IL6
18 inflammatory bowel disease 4 10.4 IL4 IL5
19 periodontitis, chronic 10.3 IL1B IL6
20 rhinosporidiosis 10.3 CD79A IL4
21 scleritis 10.3 IL4 IL5
22 strongyloidiasis 10.3 CD79A IL5
23 b-cell growth factor 10.3 IL4 IL6
24 uremic pruritus 10.2 IL1B IL6
25 intrinsic asthma 10.2 IL4 IL5
26 intestinal schistosomiasis 10.2 IL4 IL5 STAT6
27 urinary schistosomiasis 10.2 IL4 IL5 STAT6
28 atopic keratoconjunctivitis 10.2 IL4 IL5
29 papillary conjunctivitis 10.2 IL4 IL6
30 funisitis 10.2 IL1B IL6
31 angiostrongyliasis 10.2 IL4 IL5
32 food allergy 10.2 IL4 IL5 STAT6
33 glossitis 10.2 IL1B IL6
34 ige responsiveness, atopic 10.2 IL4 IL5 STAT6
35 euthyroid sick syndrome 10.2 IL1B IL6
36 gastrointestinal allergy 10.1 CD79A IL4 IL5
37 beta-lactam allergy 10.1 IL4 STAT6
38 conjunctival disease 10.1 CD79A IL4 IL5
39 laryngitis 10.1 IL1B IL6
40 milk allergy 10.1 CD79A IL4 IL5
41 allergic asthma 10.1 IL4 IL5 STAT6
42 trichinosis 10.1 IL4 IL5
43 paranasal sinus disease 10.1 CD79A IL4 IL5
44 acute diarrhea 10.1 BAG6 CD79A
45 nose disease 10.1 CD79A IL4 IL5
46 upper respiratory tract disease 10.1 CD79A IL4 IL5
47 keratoconjunctivitis 10.1 CD79A IL4 IL5
48 aspergillosis 10.1 CD79A IL4 IL5
49 apple allergy 10.1 IL4 IL5
50 cercarial dermatitis 10.1 IL1B IL4 IL5

Graphical network of the top 20 diseases related to Primary Amebic Meningoencephalitis:



Diseases related to Primary Amebic Meningoencephalitis

Symptoms & Phenotypes for Primary Amebic Meningoencephalitis

GenomeRNAi Phenotypes related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD59 CD69 CD79A CTSL GAPDH IL5

MGI Mouse Phenotypes related to Primary Amebic Meningoencephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 BAG6 C9 CD59 CD79A HM13 IL1B
2 hematopoietic system MP:0005397 10.14 POU2F1 STAT6 SULT1E1 CD59 CD69 CD79A
3 endocrine/exocrine gland MP:0005379 10.03 CD59 HM13 IL4 IL6 POU2F1 STAT6
4 immune system MP:0005387 9.97 CD69 CD79A HM13 IL1B IL4 IL5
5 liver/biliary system MP:0005370 9.8 CD79A HM13 IL4 IL5 IL6 POU2F1
6 neoplasm MP:0002006 9.63 CD79A HM13 IL1B IL5 IL6 STAT6
7 renal/urinary system MP:0005367 9.56 BAG6 CD59 CD79A HM13 IL4 IL6
8 respiratory system MP:0005388 9.17 BAG6 HM13 IL4 IL5 IL6 POU2F1

Drugs & Therapeutics for Primary Amebic Meningoencephalitis

Search Clinical Trials , NIH Clinical Center for Primary Amebic Meningoencephalitis

Genetic Tests for Primary Amebic Meningoencephalitis

Anatomical Context for Primary Amebic Meningoencephalitis

MalaCards organs/tissues related to Primary Amebic Meningoencephalitis:

41
Brain

Publications for Primary Amebic Meningoencephalitis

Articles related to Primary Amebic Meningoencephalitis:

(show top 50) (show all 79)
# Title Authors Year
1
Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States<sup>1</sup>. ( 29260676 )
2018
2
Nurse's guide to primary amebic meningoencephalitis. ( 29561369 )
2018
3
Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation. ( 29401275 )
2018
4
Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China. ( 29751112 )
2018
5
Identification of Naegleria fowleri Proteins Linked to Primary Amebic Meningoencephalitis. ( 28086072 )
2017
6
Primary Amebic Meningoencephalitis in Children: A Report ofA Two Fatal Cases and Review of the Literature. ( 28389055 )
2017
7
Primary Amebic Meningoencephalitis: What Have We Learned in the Last 5A Years? ( 27614893 )
2016
8
Notes from the Field: Primary Amebic Meningoencephalitis Associated with Exposure to Swimming Pool Water Supplied by an Overland Pipe - Inyo County, California, 2015. ( 27123690 )
2016
9
Use of the Novel Therapeutic Agent Miltefosine for the Treatment of Primary Amebic Meningoencephalitis: Report of 1 Fatal and 1 Surviving Case. ( 26679626 )
2016
10
Primary Amebic Meningoencephalitis as Cause of Headache and Fever. ( 27175836 )
2016
11
Primary amebic meningoencephalitis: Summarization on cases with early diagnosis by identification of amebae trophozoite in the cerebrospinal fluid. ( 27195047 )
2016
12
Primary Amebic Meningoencephalitis Associated with Hot Spring Exposure During International Travel - Seminole County, Florida, July 2014. ( 26540579 )
2015
13
Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis. ( 25667249 )
2015
14
The First Association of a Primary Amebic Meningoencephalitis Death With Culturable Naegleria fowleri in Tap Water From a US Treated Public Drinking Water System. ( 25595746 )
2015
15
Primary amebic meningoencephalitis associated with ritual nasal rinsinga89St Thomas, US Virgin Islands, 2012. ( 24571008 )
2014
16
Notes from the field: primary amebic meningoencephalitis associated with ritual nasal rinsing--St. Thomas, U.S. Virgin islands, 2012. ( 24226628 )
2013
17
Identification and significance of Naegleria fowleri isolated from the hot spring which related to the first primary amebic meningoencephalitis (PAM) patient in Taiwan. ( 23665128 )
2013
18
Primary amebic meningoencephalitis in Florida: a case report and epidemiological review of Florida cases. ( 23621053 )
2013
19
Seasonal primary amebic meningoencephalitis (PAM) in the south: summertime is PAM time. ( 22866356 )
2012
20
A rare case of survival from primary amebic meningoencephalitis. ( 22557831 )
2012
21
Primary amebic meningoencephalitis deaths associated with sinus irrigation using contaminated tap water. ( 22919000 )
2012
22
Photo Quiz. Primary amebic meningoencephalitis. ( 23166205 )
2012
23
Primary amebic meningoencephalitis: a case report and literature review. ( 22391923 )
2012
24
Primary amebic meningoencephalitis caused by Naegleria fowleri, Karachi, Pakistan. ( 21291600 )
2011
25
Update on emerging infections: News from the Centers for Disease Control and Prevention. Primary amebic meningoencephalitis-Arizona, Florida, and Texas, 2007. ( 19708086 )
2009
26
Primary amebic meningoencephalitis--Arizona, Florida, and Texas, 2007. ( 18509301 )
2008
27
Primary amebic meningoencephalitis. ( 19129572 )
2008
28
Synergistic activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. ( 17060522 )
2007
29
Primary amebic meningoencephalitis: a silent killer. ( 17338852 )
2006
30
Primary amebic meningoencephalitis. ( 16944619 )
2006
31
Isolation and molecular typing of Naegleria fowleri from the brain of a cow that died of primary amebic meningoencephalitis. ( 16081978 )
2005
32
Pathologic quiz case: headache in an 8-year-old child. Primary amebic meningoencephalitis due to Naegleria fowleri. ( 14736265 )
2004
33
Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. ( 14533700 )
2003
34
Activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. ( 12543653 )
2003
35
Primary amebic meningoencephalitis--Georgia, 2002. ( 14534512 )
2003
36
A light microscopy study of the migration of Naegleria fowleri from the nasal submucosa to the central nervous system during the early stage of primary amebic meningoencephalitis in mice. ( 10701563 )
2000
37
Primary amebic meningoencephalitis due to Naegleria fowleri: an autopsy case in Japan. ( 10417693 )
1999
38
Primary amebic meningoencephalitis in a patient with AIDS: unusual protozoological findings. ( 9356829 )
1997
39
Primary amebic meningoencephalitis due to Naegleria fowleri in a South American tapir. ( 9163883 )
1997
40
Primary amebic meningoencephalitis in a patient with AIDS: unusual protozoological findings. ( 8953080 )
1996
41
In vivo study of artemisinin and its derivatives against primary amebic meningoencephalitis caused by Naegleria fowleri. ( 8544041 )
1995
42
Eosinophilic cerebrospinal fluid pleocytosis and primary amebic meningoencephalitis. ( 8266252 )
1993
43
Five cases of primary amebic meningoencephalitis in Mexicali, Mexico: study of the isolates. ( 8458963 )
1993
44
Primary amebic meningoencephalitis caused by Acanthamoeba: successfully treated with cotrimoxazole. ( 8077014 )
1993
45
From the Centers for Disease Control. Primary amebic meningoencephalitis--North Carolina, 1991. ( 1640602 )
1992
46
Primary amebic meningoencephalitis--North Carolina, 1991. ( 1608390 )
1992
47
Successful treatment of primary amebic meningoencephalitis. ( 2043022 )
1991
48
Production of monoclonal antibodies to Naegleria fowleri, agent of primary amebic meningoencephalitis. ( 3308948 )
1987
49
Primary amebic meningoencephalitis. ( 3786224 )
1986
50
Primary amebic meningoencephalitis. ( 3895137 )
1985

Variations for Primary Amebic Meningoencephalitis

Expression for Primary Amebic Meningoencephalitis

Search GEO for disease gene expression data for Primary Amebic Meningoencephalitis.

Pathways for Primary Amebic Meningoencephalitis

Pathways related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 C9 CD59 CD79A CTSL IL1B IL4
2
Show member pathways
13.23 IL1B IL4 IL5 IL6 POU2F1 STAT6
3
Show member pathways
12.76 CTSL IL1B IL4 IL5 IL6
4
Show member pathways
12.45 IL1B IL4 IL5 IL6 STAT6
5 12.44 CD79A IL1B IL4 STAT6
6
Show member pathways
12.31 IL1B IL4 IL5 IL6
7
Show member pathways
12.25 IL1B IL4 IL5 IL6 STAT6
8
Show member pathways
12.21 IL1B IL4 IL6 XDH
9
Show member pathways
12.2 IL1B IL4 IL5 IL6
10
Show member pathways
12.03 CTSL IL1B IL4 IL6
11
Show member pathways
11.95 IL1B IL4 IL5 IL6
12 11.89 IL1B IL4 IL6
13
Show member pathways
11.86 IL1B IL4 STAT6
14 11.78 IL1B IL4 IL6 POU2F1 STAT6
15 11.77 C9 IL1B IL6
16 11.74 CTSL IL1B IL6
17 11.67 IL1B IL4 IL5
18
Show member pathways
11.64 IL4 IL5 POU2F1
19 11.62 IL4 IL5 IL6 POU2F1
20 11.53 IL4 IL5 STAT6
21 11.47 IL1B IL4 IL5 IL6
22 11.41 IL1B IL4 IL6
23 11.39 IL1B IL5 IL6
24 11.36 IL4 IL5 STAT6
25 11.34 CD59 IL1B IL4 IL5 IL6
26 11.2 C9 IL1B IL6
27 11.16 CD59 CD69 CD79A IL4 IL5 IL6
28 11.06 IL1B IL4 IL5 IL6
29 10.93 IL1B IL4 IL5 IL6

GO Terms for Primary Amebic Meningoencephalitis

Cellular components related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 C9 CD59 CTSL IL1B IL4 IL5
2 extracellular region GO:0005576 9.28 BAG6 C9 CD59 CTSL IL1B IL4

Biological processes related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 C9 IL1B IL4 IL5 IL6
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.54 IL1B IL5 IL6
3 positive regulation of T cell proliferation GO:0042102 9.33 IL1B IL4 IL6
4 positive regulation of immunoglobulin secretion GO:0051024 9.32 IL5 IL6
5 cytokine-mediated signaling pathway GO:0019221 9.1 IL1B IL4 IL5 IL6 POU2F1 STAT6
6 positive regulation of isotype switching to IgE isotypes GO:0048295 8.96 IL4 STAT6

Molecular functions related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.83 BAG6 C9 CD59 CD69 CD79A CTSL
2 cytokine activity GO:0005125 8.92 IL1B IL4 IL5 IL6

Sources for Primary Amebic Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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