PAM
MCID: PRM004
MIFTS: 31

Primary Amebic Meningoencephalitis (PAM)

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Primary Amebic Meningoencephalitis

MalaCards integrated aliases for Primary Amebic Meningoencephalitis:

Name: Primary Amebic Meningoencephalitis 12 53 3 15 73
Pam 53 3
Meningoencephalitis Caused by Naegleria Fowleri 53
Primary Amoebic Meningoencephalitis 53
Naegleria Fowleri Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050242
UMLS 73 C0300934

Summaries for Primary Amebic Meningoencephalitis

CDC : 3 Naegleria fowleri (commonly referred to as the “brain-eating amoeba” or “brain-eating ameba”), is a free-living microscopic ameba*, (single-celled living organism). It can cause a rare** and devastating infection of the brain called primary amebic meningoencephalitis (PAM). The ameba is commonly found in warm freshwater (e.g. lakes, rivers, and hot springs) and soil. Naegleria fowleri usually infects people when contaminated water enters the body through the nose. Once the ameba enters the nose, it travels to the brain where it causes PAM, which is usually fatal. Infection typically occurs when people go swimming or diving in warm freshwater places, like lakes and rivers. In very rare instances, Naegleria infections may also occur when contaminated water from other sources (such as inadequately chlorinated swimming pool water or heated and contaminated tap water) enters the nose 1-4. You cannot get infected from swallowing water contaminated with Naegleria.

MalaCards based summary : Primary Amebic Meningoencephalitis, also known as pam, is related to pulmonary alveolar microlithiasis and amoebiasis due to free-living amoebae. An important gene associated with Primary Amebic Meningoencephalitis is C9 (Complement C9), and among its related pathways/superpathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Renin secretion. Affiliated tissues include brain, testes and liver.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

Wikipedia : 76 Naegleriasis (also known as primary amoebic meningoencephalitis) is an infection of the brain by the... more...

Related Diseases for Primary Amebic Meningoencephalitis

Diseases related to Primary Amebic Meningoencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pulmonary alveolar microlithiasis 11.4
2 amoebiasis due to free-living amoebae 11.4
3 meningoencephalitis 11.0
4 headache 10.2
5 systemic lupus erythematosus 10.0
6 lupus erythematosus 10.0
7 meningitis 10.0
8 pneumococcal meningitis 10.0
9 granulomatous amebic encephalitis 9.3 ADCY6 CACNA1S GMPPB PSAT1

Graphical network of the top 20 diseases related to Primary Amebic Meningoencephalitis:



Diseases related to Primary Amebic Meningoencephalitis

Symptoms & Phenotypes for Primary Amebic Meningoencephalitis

Drugs & Therapeutics for Primary Amebic Meningoencephalitis

Search Clinical Trials , NIH Clinical Center for Primary Amebic Meningoencephalitis

Genetic Tests for Primary Amebic Meningoencephalitis

Anatomical Context for Primary Amebic Meningoencephalitis

MalaCards organs/tissues related to Primary Amebic Meningoencephalitis:

41
Brain, Testes, Liver, T Cells, Bone, Heart, Monocytes

Publications for Primary Amebic Meningoencephalitis

Articles related to Primary Amebic Meningoencephalitis:

(show top 50) (show all 688)
# Title Authors Year
1
Estimation of Undiagnosed Naegleria fowleri Primary Amebic Meningoencephalitis, United States<sup>1</sup>. ( 29260676 )
2018
2
Nurse's guide to primary amebic meningoencephalitis. ( 29561369 )
2018
3
Primary Amebic Meningoencephalitis Associated With Rafting on an Artificial Whitewater River: Case Report and Environmental Investigation. ( 29401275 )
2018
4
Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China. ( 29751112 )
2018
5
PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma. ( 29844863 )
2018
6
Effect of SLC34A2 gene mutation on extracellular phosphorus transport in PAM alveolar epithelial cells. ( 29375690 )
2018
7
Underwater wireless optical communication using an arrayed transmitter/receiver and optical superimposition-based PAM-4 signal. ( 29401841 )
2018
8
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. ( 29512652 )
2018
9
Silicon photonic dual-drive MIM based 56 Gb/s DAC-less and DSP-free PAM-4 transmission. ( 29529742 )
2018
10
Low-cost and miniaturized 100-Gb/s (2 × 50 Gb/s) PAM-4 TO-packaged ROSA for data center networks. ( 29529810 )
2018
11
SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells. ( 29544034 )
2018
12
Plant Genome Editing Using FnCpf1 and LbCpf1 Nucleases at Redefined and Altered PAM Sites. ( 29567452 )
2018
13
Cas4 Facilitates PAM-Compatible Spacer Selection during CRISPR Adaptation. ( 29590607 )
2018
14
Digital chromatic dispersion pre-management enabled single-lane 112  Gb/s PAM-4 signal transmission over 80  km SSMF. ( 29601013 )
2018
15
Optical single side-band Nyquist PAM-4 transmission using dual-drive MZM modulation and direct detection. ( 29609350 )
2018
16
Cousin Pam. ( 29617584 )
2018
17
PAM: A Framework for Integrated Analysis of Imaging, Single-Molecule, and Ensemble Fluorescence Data. ( 29642023 )
2018
18
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity. ( 29701957 )
2018
19
Harnessing biosynthesis and quantitative NMR for late stage functionalization of lead molecules: Application to the M1 positive allosteric modulator (PAM) program. ( 29716781 )
2018
20
Corrigendum to "Microwave initiated synthesis of polyacrylamide grafted carboxymethylstarch (CMS-g-PAM): Application as a novel matrix for sustained drug release" [Int. J. Biol. Macromol. 45 (2009) 48-55]. ( 29801919 )
2018
21
Experimental demonstration of 20-Gb/s dual-band Nyquist PAM-4 transmission over a short-reach IMDD system using super-Nyquist sampling technique. ( 29856382 )
2018
22
Cas4 Nucleases Define the PAM, Length, and Orientation of DNA Fragments Integrated at CRISPR Loci. ( 29883605 )
2018
23
PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling? ( 29885909 )
2018
24
The role of sodium carbonate in PAM coagulation-flocculation for oil acidized wastewater treatment. ( 29944132 )
2018
25
PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. ( 29997255 )
2018
26
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. ( 30054598 )
2018
27
Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in the Hartley guinea pig. ( 30056178 )
2018
28
Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model. ( 30059851 )
2018
29
Radial basis function neural network enabled C-band 4 × 50  Gb/s PAM-4 transmission over 80  km SSMF. ( 30067705 )
2018
30
Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication. ( 30071719 )
2018
31
Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184]. ( 30076050 )
2018
32
In Silico Processing of the Complete CRISPR-Cas Spacer Space for Identification of PAM Sequences. ( 30076736 )
2018
33
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures. ( 30109815 )
2018
34
Performance of M-PAM FSO communication systems in atmospheric turbulence based on APD detector. ( 30184878 )
2018
35
Transmitter and receiver DSP for 112 Gbit/s PAM-4 amplifier-less transmissions using 25G-class EML and APD. ( 30184924 )
2018
36
Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants. ( 30239882 )
2018
37
VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events. ( 30258541 )
2018
38
Novel deletion of SLC34A2 in Chinese patients of PAM shares mutation hot spot with fusion gene SLC34A2-ROS1 in lung cancer. ( 30262706 )
2018
39
A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells. ( 30317586 )
2018
40
Promoting Precision Addiction Management (PAM) to Combat the Global Opioid Crisis. ( 30370423 )
2018
41
Comparative evaluation of antidotal efficacy of 2-PAM and HNK-102 oximes during inhalation of sarin vapor in Swiss albino mice. ( 30375901 )
2018
42
Minimal PAM specificity of a highly similar SpCas9 ortholog. ( 30397647 )
2018
43
B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation. ( 30429960 )
2018
44
Pair Matcher (PaM): fast model-based optimisation of treatment/case-control matches. ( 30445488 )
2018
45
120 Gbaud PAM-4 transmission over 80-km SSMF using optical band interleaving and Kramers-Kronig detection. ( 30469687 )
2018
46
A Parallel Architecture for the Partitioning Around Medoids (PAM) Algorithm for Scalable Multi-Core Processor Implementation with Applications in Healthcare. ( 30477277 )
2018
47
Partnership for mental health development in Sub-Saharan Africa (PaM-D): a collaborative initiative for research and capacity building. ( 30479242 )
2018
48
The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate. ( 30503632 )
2018
49
Genome editing in plants by engineered CRISPR-Cas9 recognizing NG PAM. ( 30531939 )
2018
50
How adults with cardiac conditions in Singapore understand the Patient Activation Measure (PAM-13) items: a cognitive interviewing study. ( 27973921 )
2018

Variations for Primary Amebic Meningoencephalitis

Expression for Primary Amebic Meningoencephalitis

Search GEO for disease gene expression data for Primary Amebic Meningoencephalitis.

Pathways for Primary Amebic Meningoencephalitis

Pathways related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 ADCY6 CACNA1S KCNH6
2 10.77 ADCY6 CACNA1S

GO Terms for Primary Amebic Meningoencephalitis

Molecular functions related to Primary Amebic Meningoencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 8.62 CACNA1S KCNH6

Sources for Primary Amebic Meningoencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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