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MCID: PRM024
MIFTS: 40

Primary Angle-Closure Glaucoma

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Primary Angle-Closure Glaucoma

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MalaCards integrated aliases for Primary Angle-Closure Glaucoma:

Name: Primary Angle-Closure Glaucoma 12 54 15 71 32
Primary Angle Closure Glaucoma 12 17
Angle Closure Glaucoma 71

Classifications:

MalaCards categories:
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1405
ICD9CM 34 365.2
SNOMED-CT 67 392288006
ICD10 32 H40.2
UMLS 71 C0017605 C0017606
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Summaries for Primary Angle-Closure Glaucoma

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Disease Ontology : 12 An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.

MalaCards based summary : Primary Angle-Closure Glaucoma, also known as primary angle closure glaucoma, is related to acute closed-angle glaucoma and intraocular pressure quantitative trait locus, and has symptoms including progressive peripheral vision loss An important gene associated with Primary Angle-Closure Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways is Ondansetron Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Acetazolamide and Topiramate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are Resistant to vaccinia virus (VACV-A4L) infection and immune system

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Related Diseases for Primary Angle-Closure Glaucoma

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Diseases related to Primary Angle-Closure Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 acute closed-angle glaucoma 33.3 OPTN MYOC CALCRL
2 intraocular pressure quantitative trait locus 32.1 OPTN MYOC CYP1B1
3 glaucoma, primary open angle 31.2 TXNRD2 OPTN MYOC CYP1B1
4 open-angle glaucoma 31.1 OPTN MYOC MTHFR CYP1B1
5 optic nerve disease 30.7 PARL OPTN MYOC
6 corneal edema 30.7 MYOC KERA CYP1B1
7 amaurosis fugax 30.4 MTHFR MMP9
8 nanophthalmos 30.1 PRSS56 PLEKHA7 MYOC KERA
9 chronic closed-angle glaucoma 12.1
10 interval angle-closure glaucoma 11.7
11 cataract 11.0
12 yemenite deaf-blind hypopigmentation syndrome 10.9
13 refractive error 10.6
14 joint laxity, short stature, and myopia 10.5
15 myopia 10.5
16 ocular hypertension 10.5
17 early-onset glaucoma 10.4 MYOC CYP1B1
18 traumatic glaucoma 10.3 MYOC CYP1B1
19 retinitis pigmentosa 10.3
20 neuroretinitis 10.3
21 microphthalmia 10.3
22 retinitis 10.3
23 neuropathy 10.3
24 excessive tearing 10.3 MYOC CYP1B1
25 mycetoma 10.3 MMP9 CYP1B1
26 megalocornea 10.3 MYOC CYP1B1 COL11A1
27 stickler syndrome 10.3 PLEKHA7 PCMTD1 COL11A1
28 hydrophthalmos 10.3 MYOC CYP1B1
29 retinal detachment 10.2
30 lens subluxation 10.2
31 uveitis 10.2
32 eye disease 10.2
33 scotoma 10.2
34 senile cataract 10.2
35 cytokine deficiency 10.2
36 farsightedness 10.2
37 pik3ca-related overgrowth syndrome 10.2
38 microphthalmia, isolated 2 10.2 MYOC CYP1B1
39 glaucoma 1, open angle, a 10.2 OPTN MYOC CYP1B1
40 marshall syndrome 10.1 PLEKHA7 PCMTD1 FAM102A COL11A1
41 glaucoma-related pigment dispersion syndrome 10.1 OPTN MYOC CYP1B1
42 juvenile glaucoma 10.1 OPTN MYOC CYP1B1
43 primary congenital glaucoma 10.1 OPTN MYOC CYP1B1
44 optic atrophy 3, autosomal dominant 10.1
45 optic atrophy 1 10.1
46 exfoliation syndrome 10.1
47 cornea plana 2, autosomal recessive 10.1
48 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
49 leber optic atrophy 10.1
50 retinoschisis 1, x-linked, juvenile 10.1

Comorbidity relations with Primary Angle-Closure Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to Primary Angle-Closure Glaucoma
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Symptoms & Phenotypes for Primary Angle-Closure Glaucoma

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Symptoms:

12
  • • progressive peripheral vision loss

GenomeRNAi Phenotypes related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Resistant to vaccinia virus (VACV-A4L) infection GR00351-A-1 9.23 CALCRL COL11A1 GLIS3 HTR3C HTR3D KERA

MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 ABCC5 CALCRL COL11A1 DPM2 KERA MMP9
Sources

Drugs & Therapeutics for Primary Angle-Closure Glaucoma

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Drugs for Primary Angle-Closure Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Topiramate Approved Phase 4 97240-79-4 5284627
3
Pilocarpine Approved, Investigational Phase 4 54-71-7, 92-13-7 5910
4
Travoprost Approved Phase 4 157283-68-6 5282226
5
Brinzolamide Approved Phase 4 138890-62-7 68844
6
Timolol Approved Phase 4 26839-75-8 5478 33624
7
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
8 diuretics Phase 4
9 Anticonvulsants Phase 4
10 Hypoglycemic Agents Phase 4
11 Cholinergic Agents Phase 4
12 Muscarinic Agonists Phase 4
13 Adrenergic beta-Antagonists Phase 4
14 Adrenergic Antagonists Phase 4
15 Antihypertensive Agents Phase 4
16 Adrenergic Agents Phase 4
17 Anti-Arrhythmia Agents Phase 4
18 Neurotransmitter Agents Phase 4
19 Adrenergic alpha-Agonists Phase 4
20 Adrenergic Agonists Phase 4
21 Ophthalmic Solutions Phase 4
22 Brimonidine Tartrate Phase 4 70359-46-5
23 Carbonic Anhydrase Inhibitors Phase 4
24 Pharmaceutical Solutions Phase 4
25
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
27
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
28
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
29 Adjuvants, Immunologic Phase 3
30 (T,G)-A-L Phase 3
31
Glatiramer Acetate Phase 3 147245-92-9 3081884
32 Antirheumatic Agents Phase 3
33 Immunologic Factors Phase 2, Phase 3
34 Immunosuppressive Agents Phase 2, Phase 3
35 Hormones Phase 2, Phase 3
36 glucocorticoids Phase 2, Phase 3
37 triamcinolone acetonide Phase 2, Phase 3
38 Triamcinolone diacetate Phase 2, Phase 3
39 Hormone Antagonists Phase 2, Phase 3
40 Triamcinolone hexacetonide Phase 2, Phase 3
41 Anti-Inflammatory Agents Phase 2, Phase 3
42 Mitomycins Phase 2, Phase 3
43 Alkylating Agents Phase 2, Phase 3
44 Anti-Bacterial Agents Phase 2, Phase 3
45 Antibiotics, Antitubercular Phase 2, Phase 3
46 Endothelial Growth Factors Phase 2, Phase 3
47 Mitogens Phase 2, Phase 3
48 Gentamicins Phase 2, Phase 3
49 Angiogenesis Inhibitors Phase 2, Phase 3
50 Antimetabolites Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 EFFECTS OF IMMEDIATE ARGON LASER PERIPHERAL IRIDOPLASTY Versus CONVENTIONAL SYSTEMIC MEDICAL THERAPY ON OPTIC NERVE HEAD STRUCTURE AND FUNCTION OF ACUTE PRIMARY ANGLE CLOSURE EYES Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
2 Relationship Between Topiramate Use and Ocular Angle Status: A Prospective Pilot Study Unknown status NCT00153699 Phase 4 Topiramate
3 Combined Phacoemulsification and Glaucoma Implant Surgery Versus Combined Phacoemulsification and Trabeculectomy: A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
4 A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
5 An 8 Week, Single Masked, Parallel-Group, Exploratory Study Comparing Ocular Surface Signs and Symptoms in Monotherapy Ocular Hypertension or Glaucoma Patients Randomized to Either Xalatan® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
6 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
7 A Double-Masked, Parallel-Group, Efficacy and Safety Study of Brinzolamide 1.0% (AZOPT) as Adjunctive Therapy to Travoprost 0.004% (TRAVATAN) in Patients With Chronic Angle-Closure Glaucoma Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
8 Argon Laser Peripheral Iridoplasty for Primary Angle Closure Glaucoma: A Randomised Controlled Trial Unknown status NCT00980473 Phase 3 Travatan/ Timolol/Azopt
9 Comparison of Selective Laser Trabeculoplasty With Prostaglandin Analogues for Lowering Intraocular Pressure in Eyes With Primary Angle Closure Glaucoma Unknown status NCT01004900 Phase 3 Travoprost/ Timolol/ Azopt/ Brimonidine
10 Investigating the Neuroprotective Effect of Cop-1 in Acute Primary Angle Closure Unknown status NCT01936129 Phase 3 Copaxone;Placebo (buffered normal saline w/v)
11 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma. Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
12 The Effect of Intracameral Triesence (Triamcinolone Acetonide Injectable Suspension) on Ocular Inflammation After Trabeculectomy, Tube Shunt Implantation or Combined Trabeculectomy With Cataract Surgery Completed NCT00853905 Phase 2, Phase 3 Triesence;balanced salt solution BSS
13 Comprative Study of the Safety and Effectiveness Between Oculusgen (Ologen) Collagen Matrix Implant and Mitomycin-C in Glaucoma Filtering Surgery Completed NCT00524758 Phase 3 MMC in Trabeculectomy
14 Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma: A Randomized Pilot Trial. Completed NCT02901236 Phase 2, Phase 3 Mitomycin C;Bevacizumab
15 A Prospective, Multicenter Clinical Trial Designed to Evaluate the Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma Recruiting NCT03362931 Phase 3
16 A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
17 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2 QPI-1007 Injection;(including placebo)
18 Decorin as an Antifibrotic Agent in Sub Scleral Trabeculectomy: A Pilot Study Not yet recruiting NCT03924544 Phase 1 Decorin;Mitomycin c
19 Optical Coherence Tomography Quantitative Analysis of Changes in Anterior Chamber After Laser Peripheral Lridotomy Unknown status NCT02279472
20 Prospective Study on Ex-PRESS Implantation Combined With Phacoemulsification in Primary Angle-closure Glaucoma Unknown status NCT03323138
21 Prophylactic Laser Iridotomy for Eyes With Narrow Drainage Angles; A Randomised Controlled Trial Unknown status NCT00347178
22 Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Chinese Primary Angle Closure Glaucoma Unknown status NCT02964676
23 National Taiwan University Hospital Unknown status NCT00155857
24 Structural and Functional Parameters in Caucasian Patients With Angle Closure on SS-OCT Unknown status NCT02054403
25 Clinical Study of Laser Peripheral Iridoplasty With Different Laser Wavelengths Unknown status NCT02901730
26 Clinical Study of Laser Peripheral Iridoplasty on Different Sites of Iris Unknown status NCT02870504
27 Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects Unknown status NCT00823706
28 Comparison of Bimatoprost and Lataprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
29 Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma Unknown status NCT00739154
30 Corneal Endothelial Cell Loss After Trabeculectomy Versus Combined Trabeculectomy Phakoemulsification and IOL Implantation Unknown status NCT03107000
31 Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma Completed NCT03159780
32 A Prospective, Open Label Study Assessing the 24-hour Intraocular Pressure Pattern Monitored by SENSIMED Triggerfish® in Primary Angle Closure and Primary Angle Closure Glaucoma Patients, Before and After Laser Peripheral Iridotomy Completed NCT01906138
33 Phacoemulsification Versus Phacoemulsification With Micro-bypass Stent Implantation in Primary Angle Closure and Primary Angle Closure Glaucoma: Randomized Double-masked Clinical Trial Completed NCT03647033
34 Comparison of Superior vs Nasal/Temporal Laser Peripheral Iridotomy in Primary Angle Closure Completed NCT03187821
35 A Randomised Comparative Study of the Effects of Cataract Extraction With Lens Implant Alone Versus Cataract Extraction With Lens Implant and Goniosynechialysis on Outflow Facility in Patients With Primary Angle Closure Glaucoma. Completed NCT00719290
36 Comparison of Combined Phacotrabeculectomy and Trabeculectomy Only in the Treatment of Primary Angle-closure Glaucoma Completed NCT01298635
37 Laser Peripheral Iridotomy Induced Changes in Corneal Densitometry in Acute Primary Angle Closure Glaucoma Cases Completed NCT04254458
38 Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant Completed NCT00350428
39 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
40 Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure Completed NCT01923454 Acetazolamide
41 The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure Completed NCT02539758
42 A Randomized Clinical Trial Comparing Phacoemulsification and Goniosynechialysis With Phacoemulsification Alone in the Management of Primary Angle Closure Completed NCT02376725
43 Head of Glaucoma, Clinical Professor Completed NCT03686072
44 Prospective Evaluation of the Efficacy of Pascal Laser Iridotomy and Pascal Laser Peripheral Iridoplasty: A Pilot Study Completed NCT01020071
45 Biometric Indicators of Eyes With Occult Lens Subluxation Completed NCT03752710
46 A Novel Prophylactic Peripheral Iridectomy Prevents Aphakic Angle-closure Glaucoma After Congenital Cataract Surgery Completed NCT03610295
47 Incidence of Visual Symptom Following Laser (Nd:YAG ) Peripheral Iridotomy (LPI) in Relation to Position of LPI Completed NCT01758237
48 Randomized Clinical Trial Comparing Neodynium:Ytrium-aluminium-garnet (Nd:YAG) Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy in Patients With Dark Iris Completed NCT02474238
49 Comparison of Visante and Cirrus Optical Coherent Tomography for Assessment of the Anterior Segment Completed NCT01895686
50 Baerveldt Glaucoma Implant Versus Ahmed Glaucoma Implant in One- Year Follow up, Comparative Study Completed NCT04215575

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Demecarium
demecarium bromide
Echothiophate Iodide
Methazolamide
Pilocarpine
Pilocarpine Hydrochloride
Pilocarpine Nitrate
Sources

Genetic Tests for Primary Angle-Closure Glaucoma

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Anatomical Context for Primary Angle-Closure Glaucoma

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MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

40
Eye, Testes, Endothelial, Retina, Brain, Cortex, Neutrophil
Sources

Publications for Primary Angle-Closure Glaucoma

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Articles related to Primary Angle-Closure Glaucoma:

(show top 50) (show all 1143)
# Title Authors PMID Year
1
[Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma]. 54 61
18841557 2008
2
Molecular analysis of the myocilin gene in Chinese subjects with chronic primary-angle closure glaucoma. 61 54
15790895 2005
3
Retrospective case-control data of serum nitrotyrosine level and clinical biomedical indices in primary glaucoma patients. 61
32490078 2020
4
Angle-Closure Detection in Anterior Segment OCT Based on Multilevel Deep Network. 61
30794201 2020
5
Peroxynitrite is a novel risk factor and treatment target of glaucoma. 61
32222418 2020
6
Evaluation of the association between five genetic variants and primary open-angle glaucoma in a Han Chinese population. 61
32281515 2020
7
Comparison of perimetric Glaucoma Staging Systems in Asians with primary glaucoma. 61
32518400 2020
8
Newly Onset Optic Disc Pit Maculopathy (ODP-M) in a Patient With Primary Angle-closure Glaucoma (PACG) After Surgical Iridectomy: A Case Report. 61
32282435 2020
9
Evaluation of the genetic association between early-onset primary angle-closure glaucoma and retinitis pigmentosa. 61
32562694 2020
10
Coding Variants in HOOK2 and GTPBP3 May Contribute to Risk of Primary Angle Closure Glaucoma. 61
32397755 2020
11
Combined Phacoemulsification with Goniosynechialysis Under Ophthalmic Endoscope for Primary Angle-closure Glaucoma after Failed Trabeculectomy. 61
32555057 2020
12
Predictors of narrow angle detection rate-a longitudinal study of Massachusetts residents over 1.7 million person years. 61
32494044 2020
13
Quantification of Iridotrabecular Contact in Primary Angle Closure Disease. 61
32555058 2020
14
Non-contact tests for identifying people at risk of primary angle closure glaucoma. 61
32468576 2020
15
A technique for shotgun proteomic analysis of the precorneal tear film in dogs with naturally occurring primary glaucoma. 61
32364655 2020
16
Phacoemulsification vs phacoemulsification with micro-bypass stent implantation in primary angle closure and primary angle closure glaucoma: A randomized single-masked clinical study. 61
32003538 2020
17
Glaucomatous Progression after Lens Extraction in Primary Angle Closure Disease Spectrum. 61
32366776 2020
18
Long term outcomes of cataract surgery in severe and end stage primary angle closure glaucoma with controlled IOP: a retrospective study. 61
32306921 2020
19
Clear Lens Extraction in Eyes with Primary Angle Closure and Primary Angle-Closure Glaucoma. 61
32339525 2020
20
Altered effective connectivity of primary visual cortex in primary angle closure glaucoma using Granger causality analysis. 61
31390872 2020
21
Association between 17-β-estradiol and IL-8 and visual field progression in postmenopausal women with primary angle closure glaucoma. 61
32360861 2020
22
Relationship between nailfold capillary morphology and retinal thickness and retinal vessel density in primary open-angle and angle-closure glaucoma. 61
32243735 2020
23
Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma. 61
32339198 2020
24
Frequency-specific oscillations synchronization in primary angle-closure glaucoma. 61
31475845 2020
25
Association of High-Mobility Group Box-1 with Inflammation-Related Cytokines in the Aqueous Humor with Acute Primary Angle-Closure eyes. 61
32282301 2020
26
Role of matrix metalloproteinase-9 gene polymorphisms in glaucoma: A hospital-based study in Chinese patients. 61
31713905 2020
27
Optic Disc and Macular Vessel Density Measured by Optical Coherence Tomography Angiography in Open-Angle and Angle-Closure Glaucoma. 61
32221379 2020
28
In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans. 61
32186670 2020
29
Primary angle closure glaucoma genomic associations and disease mechanism. 61
31895154 2020
30
Response to: Mitomycin C-augmented Phacotrabeculectomy Versus Phacoemulsification in Primary Angle-closure Glaucoma: A Randomized Controlled Study. 61
31876880 2020
31
Mitomycin C-augmented Phacotrabeculectomy Versus Phacoemulsification in Primary Angle-closure Glaucoma: A Randomized Controlled Study. 61
31972593 2020
32
Appositional angle closure and conversion of primary angle closure into glaucoma after laser peripheral iridotomy. 61
31160423 2020
33
Biometric indicators of eyes with occult lens subluxation inducing secondary acute angle closure. 61
32138781 2020
34
Iris and its relevance to angle closure disease: a review. 61
32193222 2020
35
Association of hepatocyte growth factor gene polymorphisms with primary angle closure glaucoma from Lahore, Pakistan. 61
32063608 2020
36
Genetic Basis of Primary Angle Closure Glaucoma: The Role of Collagens and Extracellular Matrix. 61
32095201 2020
37
Pentacam changes in primary angle-closure glaucoma after different lines of treatment. 61
32399410 2020
38
Phacoemulsification Versus Phacotrabeculectomy in Primary Angle-closure Glaucoma With Cataract: Long-Term Clinical Outcomes. 61
31702714 2020
39
Effect of Phacoemulsification on Anterior Chamber Angle in Eyes with Medically Uncontrolled Filtered Primary Angle-Closure Glaucoma. 61
32377424 2020
40
[Iris shape change and risk of anterior chamber angle closure]. 61
32366076 2020
41
Anterior Segment Optical Coherence Tomography: Is There a Clinical Role in the Management of Primary Angle Closure Disease? 61
31490798 2020
42
Outcome of peripheral iridotomy in subjects with uveitis. 61
31289035 2020
43
Ripasudil Hydrochloride Hydrate in the Treatment of Glaucoma: Safety, Efficacy, and Patient Selection. 61
32440089 2020
44
Proportion of Glaucoma among Voluntary People Coming for Glaucoma Screening Program at Jimma University Department of Ophthalmology, Jimma, Ethiopia. 61
32116428 2020
45
[Comparative study of factors associated with the progression of primary open-angle and angle-closure glaucoma]. 61
32366072 2020
46
[Biomechanical properties of the cornea as predictors of the effectiveness of selective laser trabeculoplasty]. 61
32241965 2020
47
Impact of Ocular Surface Disease Treatment in Patients with Glaucoma. 61
32021074 2020
48
[Rational application of lens extraction for primary angle-closure glaucoma]. 61
31937057 2020
49
Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran. 61
32095208 2020
50
Outcomes of 1.8-3.0 mm incision phacoemulsification combined with trabeculectomy for primary angle-closure glaucoma with cataract. 61
32090033 2020
Sources

Variations for Primary Angle-Closure Glaucoma

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Expression for Primary Angle-Closure Glaucoma

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Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.
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Pathways for Primary Angle-Closure Glaucoma

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Pathways related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Ondansetron Pathway, Pharmacokinetics/Pharmacodynamics 60
Show member pathways
 9.83 HTR3D HTR3C
Sources

GO Terms for Primary Angle-Closure Glaucoma

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Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 9.16 PARL MMP9
2 regulation of reactive oxygen species metabolic process GO:2000377 8.96 PARL CYP1B1
3 serotonin receptor signaling pathway GO:0007210 8.62 HTR3D HTR3C

Molecular functions related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin-gated cation-selective channel activity GO:0022850 8.62 HTR3D HTR3C
Sources

Sources for Primary Angle-Closure Glaucoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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