Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: PRM024
MIFTS: 38

Primary Angle-Closure Glaucoma

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Primary Angle-Closure Glaucoma

About this section

MalaCards integrated aliases for Primary Angle-Closure Glaucoma:

Name: Primary Angle-Closure Glaucoma 12 54 15 71 32
Primary Angle Closure Glaucoma 12 17
Angle Closure Glaucoma 71

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1405
ICD9CM 34 365.2 365.20
SNOMED-CT 67 42456004
ICD10 32 H40.2 H40.20
UMLS 71 C0017605 C0017606
Sources

Summaries for Primary Angle-Closure Glaucoma

About this section
MalaCards based summary : Primary Angle-Closure Glaucoma, also known as primary angle closure glaucoma, is related to intraocular pressure quantitative trait locus and glaucoma, primary open angle. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are Syndecan-1-mediated signaling events and Tropisetron Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Acetazolamide and Topiramate have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are Decreased HPV16-GFP infection and Resistant to vaccinia virus (VACV-A4L) infection

Sources

Related Diseases for Primary Angle-Closure Glaucoma

About this section

Diseases related to Primary Angle-Closure Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 intraocular pressure quantitative trait locus 32.1 OPTN MYOC CYP1B1
2 glaucoma, primary open angle 31.7 OPTN MYOC CYP1B1
3 acute closed-angle glaucoma 31.3 OPTN MYOC CALCRL
4 open-angle glaucoma 31.2 OPTN MYOC MTHFR CYP1B1
5 optic nerve disease 31.1 PARL OPTN MYOC
6 refractive error 30.9 PRSS56 MMP9 HGF
7 corneal edema 30.8 MYOC KERA CYP1B1
8 amaurosis fugax 30.5 MTHFR MMP9
9 myopia 30.4 PRSS56 MYOC HGF COL11A1
10 cataract 10.9
11 yemenite deaf-blind hypopigmentation syndrome 10.9
12 chronic closed-angle glaucoma 10.7
13 ocular hypertension 10.5
14 microphthalmia 10.4
15 early-onset glaucoma 10.4 MYOC CYP1B1
16 excessive tearing 10.4 MYOC CYP1B1
17 neuropathy 10.3
18 mycetoma 10.3 MMP9 CYP1B1
19 megalocornea 10.3 MYOC CYP1B1 COL11A1
20 hydrophthalmos 10.3 MYOC CYP1B1
21 retinitis pigmentosa 10.2
22 neuroretinitis 10.2
23 lens subluxation 10.2
24 uveitis 10.2
25 retinitis 10.2
26 eye disease 10.2
27 scotoma 10.2
28 senile cataract 10.2
29 cytokine deficiency 10.2
30 farsightedness 10.2
31 pik3ca-related overgrowth syndrome 10.2
32 microphthalmia, isolated 2 10.2 MYOC CYP1B1
33 glaucoma 1, open angle, a 10.2 OPTN MYOC CYP1B1
34 steroid-induced glaucoma 10.2 OPTN MYOC CYP1B1
35 phacogenic glaucoma 10.2 OPTN MYOC CYP1B1
36 juvenile glaucoma 10.2 OPTN MYOC CYP1B1
37 primary congenital glaucoma 10.1 OPTN MYOC CYP1B1
38 glaucoma, normal tension 10.1 OPTN MYOC CYP1B1
39 optic atrophy 3, autosomal dominant 10.1
40 optic atrophy 1 10.1
41 exfoliation syndrome 10.1
42 retinal detachment 10.1
43 cornea plana 2, autosomal recessive 10.1
44 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
45 leber optic atrophy 10.1
46 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.1
47 inflammatory bowel disease 10.1
48 cornea plana 10.1
49 cycloplegia 10.1
50 aqueous misdirection 10.1

Comorbidity relations with Primary Angle-Closure Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to Primary Angle-Closure Glaucoma
Sources

Symptoms & Phenotypes for Primary Angle-Closure Glaucoma

About this section

GenomeRNAi Phenotypes related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 9.26 CYP1B1 HGF HTR3D MTHFR
2 Resistant to vaccinia virus (VACV-A4L) infection GR00351-A-1 9.23 CALCRL COL11A1 GLIS3 HTR3C HTR3D KERA

MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.17 GLIS3 HGF MTHFR MYOC OPTN PARL
Sources

Drugs & Therapeutics for Primary Angle-Closure Glaucoma

About this section

Drugs for Primary Angle-Closure Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
2
Topiramate Approved Phase 4 97240-79-4 5284627
3
Pilocarpine Approved, Investigational Phase 4 92-13-7, 54-71-7 5910
4
Timolol Approved Phase 4 26839-75-8 33624 5478
5
Brinzolamide Approved Phase 4 138890-62-7 68844
6
Travoprost Approved Phase 4 157283-68-6 5282226
7
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
8
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
9 Natriuretic Agents Phase 4
10 diuretics Phase 4
11 Anticonvulsants Phase 4
12 Hypoglycemic Agents Phase 4
13 Autonomic Agents Phase 4
14 Muscarinic Agonists Phase 4
15 Cholinergic Agents Phase 4
16 Neurotransmitter Agents Phase 4
17 Anti-Arrhythmia Agents Phase 4
18 Adrenergic beta-Antagonists Phase 4
19 Adrenergic Antagonists Phase 4
20 Antihypertensive Agents Phase 4
21 Adrenergic Agents Phase 4
22 Adrenergic alpha-2 Receptor Agonists Phase 4
23 Adrenergic Agonists Phase 4
24 Ophthalmic Solutions Phase 4
25 Brimonidine Tartrate Phase 4 70359-46-5
26 Carbonic Anhydrase Inhibitors Phase 4
27 Pharmaceutical Solutions Phase 4
28 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
29
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
31
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
32
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
33 Adjuvants, Immunologic Phase 3
34 Protective Agents Phase 3
35 (T,G)-A-L Phase 3
36 Antirheumatic Agents Phase 3
37 Neuroprotective Agents Phase 3
38
Glatiramer Acetate Phase 3 147245-92-9 3081884
39 Immunologic Factors Phase 2, Phase 3
40 Immunosuppressive Agents Phase 2, Phase 3
41 Hormone Antagonists Phase 2, Phase 3
42 triamcinolone acetonide Phase 2, Phase 3
43 Anti-Inflammatory Agents Phase 2, Phase 3
44 Triamcinolone diacetate Phase 2, Phase 3
45 glucocorticoids Phase 2, Phase 3
46 Hormones Phase 2, Phase 3
47 Triamcinolone hexacetonide Phase 2, Phase 3
48 Anti-Bacterial Agents Phase 2, Phase 3
49 Alkylating Agents Phase 2, Phase 3
50 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 EFFECTS OF IMMEDIATE ARGON LASER PERIPHERAL IRIDOPLASTY Versus CONVENTIONAL SYSTEMIC MEDICAL THERAPY ON OPTIC NERVE HEAD STRUCTURE AND FUNCTION OF ACUTE PRIMARY ANGLE CLOSURE EYES Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
2 Relationship Between Topiramate Use and Ocular Angle Status: A Prospective Pilot Study Unknown status NCT00153699 Phase 4 Topiramate
3 Combined Phacoemulsification and Glaucoma Implant Surgery Versus Combined Phacoemulsification and Trabeculectomy: A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
4 A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
5 An 8 Week, Single Masked, Parallel-Group, Exploratory Study Comparing Ocular Surface Signs and Symptoms in Monotherapy Ocular Hypertension or Glaucoma Patients Randomized to Either Xalatan® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
6 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
7 A Double-Masked, Parallel-Group, Efficacy and Safety Study of Brinzolamide 1.0% (AZOPT) as Adjunctive Therapy to Travoprost 0.004% (TRAVATAN) in Patients With Chronic Angle-Closure Glaucoma Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
8 Argon Laser Peripheral Iridoplasty for Primary Angle Closure Glaucoma: A Randomised Controlled Trial Unknown status NCT00980473 Phase 3 Travatan/ Timolol/Azopt
9 Comparison of Selective Laser Trabeculoplasty With Prostaglandin Analogues for Lowering Intraocular Pressure in Eyes With Primary Angle Closure Glaucoma Unknown status NCT01004900 Phase 3 Travoprost/ Timolol/ Azopt/ Brimonidine
10 Investigating the Neuroprotective Effect of Cop-1 in Acute Primary Angle Closure Unknown status NCT01936129 Phase 3 Copaxone;Placebo (buffered normal saline w/v)
11 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma. Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
12 The Effect of Intracameral Triesence (Triamcinolone Acetonide Injectable Suspension) on Ocular Inflammation After Trabeculectomy, Tube Shunt Implantation or Combined Trabeculectomy With Cataract Surgery Completed NCT00853905 Phase 2, Phase 3 Triesence;balanced salt solution BSS
13 Comprative Study of the Safety and Effectiveness Between Oculusgen (Ologen) Collagen Matrix Implant and Mitomycin-C in Glaucoma Filtering Surgery Completed NCT00524758 Phase 3 MMC in Trabeculectomy
14 Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma: A Randomized Pilot Trial. Completed NCT02901236 Phase 2, Phase 3 Mitomycin C;Bevacizumab
15 A Prospective, Multicenter Clinical Trial Designed to Evaluate the Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma Recruiting NCT03362931 Phase 3
16 A Prospective Study to Assess the Hypotensive Efficacy of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
17 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2 QPI-1007 Injection;(including placebo)
18 Decorin as an Antifibrotic Agent in Sub Scleral Trabeculectomy: A Pilot Study Not yet recruiting NCT03924544 Phase 1 Decorin;Mitomycin c
19 Optical Coherence Tomography Quantitative Analysis of Changes in Anterior Chamber After Laser Peripheral Lridotomy Unknown status NCT02279472
20 Prospective Study on Ex-PRESS Implantation Combined With Phacoemulsification in Primary Angle-closure Glaucoma Unknown status NCT03323138
21 Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Chinese Primary Angle Closure Glaucoma Unknown status NCT02964676
22 Prophylactic Laser Iridotomy for Eyes With Narrow Drainage Angles; A Randomised Controlled Trial Unknown status NCT00347178
23 National Taiwan University Hospital Unknown status NCT00155857
24 Structural and Functional Parameters in Caucasian Patients With Angle Closure on SS-OCT Unknown status NCT02054403
25 Clinical Study of Laser Peripheral Iridoplasty on Different Sites of Iris Unknown status NCT02870504
26 Clinical Study of Laser Peripheral Iridoplasty With Different Laser Wavelengths Unknown status NCT02901730
27 Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects Unknown status NCT00823706
28 Comparison of Bimatoprost and Lataprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
29 Clinical Cohort Study of Association Between Steady State Phenytoin Treatment and Better Clinical Parameters of Glaucoma Unknown status NCT00739154
30 Corneal Endothelial Cell Loss After Trabeculectomy Versus Combined Trabeculectomy Phakoemulsification and IOL Implantation Unknown status NCT03107000
31 Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma Completed NCT03159780
32 A Prospective, Open Label Study Assessing the 24-hour Intraocular Pressure Pattern Monitored by SENSIMED Triggerfish® in Primary Angle Closure and Primary Angle Closure Glaucoma Patients, Before and After Laser Peripheral Iridotomy Completed NCT01906138
33 Phacoemulsification Versus Phacoemulsification With Micro-bypass Stent Implantation in Primary Angle Closure and Primary Angle Closure Glaucoma: Randomized Double-masked Clinical Trial Completed NCT03647033
34 Comparison of Superior vs Nasal/Temporal Laser Peripheral Iridotomy in Primary Angle Closure Completed NCT03187821
35 A Randomised Comparative Study of the Effects of Cataract Extraction With Lens Implant Alone Versus Cataract Extraction With Lens Implant and Goniosynechialysis on Outflow Facility in Patients With Primary Angle Closure Glaucoma. Completed NCT00719290
36 Comparison of Combined Phacotrabeculectomy and Trabeculectomy Only in the Treatment of Primary Angle-closure Glaucoma Completed NCT01298635
37 Angle Closure: Laser Iridotomy Versus Phacoemulsification Study (ACLIPS)- A Study of Acute Primary Angle Closure Glaucoma Comparing Two Treatment Modalities: Laser Peripheral vs Phacoemulsification With Posterior Intraocular Lens Implant Completed NCT00350428
38 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
39 Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure Completed NCT01923454 Acetazolamide
40 The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure Completed NCT02539758
41 A Randomized Clinical Trial Comparing Phacoemulsification and Goniosynechialysis With Phacoemulsification Alone in the Management of Primary Angle Closure Completed NCT02376725
42 Head of Glaucoma, Clinical Professor Completed NCT03686072
43 Prospective Evaluation of the Efficacy of Pascal Laser Iridotomy and Pascal Laser Peripheral Iridoplasty: A Pilot Study Completed NCT01020071
44 Biometric Indicators of Eyes With Occult Lens Subluxation Completed NCT03752710
45 A Novel Prophylactic Peripheral Iridectomy Prevents Aphakic Angle-closure Glaucoma After Congenital Cataract Surgery Completed NCT03610295
46 Incidence of Visual Symptom Following Laser (Nd:YAG ) Peripheral Iridotomy (LPI) in Relation to Position of LPI Completed NCT01758237
47 Comparison of Visante and Cirrus Optical Coherent Tomography for Assessment of the Anterior Segment Completed NCT01895686
48 Randomized Clinical Trial Comparing Neodynium:Ytrium-aluminium-garnet (Nd:YAG) Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy in Patients With Dark Iris Completed NCT02474238
49 What is the Effect of the "Water Drinking Test" on Patients With Narrow Angles on the Day of Their Scheduled Laser Iridotomy? Completed NCT02613533
50 The Effect of Mozart Music on Visual Field Testing in Glaucoma Patients: Will Music Tame the Savage Perimeter? Completed NCT01027039

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Demecarium
demecarium bromide
Echothiophate Iodide
Methazolamide
Pilocarpine
Pilocarpine Hydrochloride
Pilocarpine Nitrate
Sources

Genetic Tests for Primary Angle-Closure Glaucoma

About this section
Sources

Anatomical Context for Primary Angle-Closure Glaucoma

About this section

MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

40
Eye, Testes, Endothelial, Retina, Brain, Cortex, Neutrophil
Sources

Publications for Primary Angle-Closure Glaucoma

About this section

Articles related to Primary Angle-Closure Glaucoma:

(show top 50) (show all 1109)
# Title Authors PMID Year
1
[Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma]. 54 61
18841557 2008
2
Molecular analysis of the myocilin gene in Chinese subjects with chronic primary-angle closure glaucoma. 54 61
15790895 2005
3
Primary angle closure glaucoma genomic associations and disease mechanism. 61
31895154 2020
4
Impact of Ocular Surface Disease Treatment in Patients with Glaucoma. 61
32021074 2020
5
[Rational application of lens extraction for primary angle-closure glaucoma]. 61
31937057 2020
6
Mitomycin C-augmented Phacotrabeculectomy Versus Phacoemulsification in Primary Angle-closure Glaucoma: A Randomized Controlled Study. 61
31972593 2020
7
Phacoemulsification Versus Phacotrabeculectomy in Primary Angle-closure Glaucoma With Cataract: Long-Term Clinical Outcomes. 61
31702714 2020
8
Outcome of peripheral iridotomy in subjects with uveitis. 61
31289035 2020
9
Phacoemulsification vs phacoemulsification with micro-bypass stent implantation in primary angle closure and primary angle closure glaucoma: A randomized single-masked clinical study. 61
32003538 2020
10
Anterior Segment Optical Coherence Tomography: Is There a Clinical Role in the Management of Primary Angle Closure Disease? 61
31490798 2020
11
Bilateral aqueous misdirection syndrome after routine cataract surgery in angle closure. 61
31856996 2019
12
Response: Mitomycin C-augmented Phacotrabeculectomy versus Phacoemulsification in Primary Angle Closure Glaucoma: A Randomized Controlled Study. 61
31876880 2019
13
Combined phacoemulsification-viscosynechialysis-trabeculotomy vs phacotrabeculectomy in uncontrolled primary angle-closure glaucoma with cataract. 61
31856984 2019
14
Integration of Genetic and Biometric Risk Factors for Detection of Primary Angle Closure Glaucoma. 61
31377279 2019
15
The genetics of angle closure glaucoma. 61
31634478 2019
16
Case Series of Combined XEN Implantation and Phacoemulsification in Chinese Eyes: One-Year Outcomes. 61
31650513 2019
17
Lowered Decorin With Aberrant Extracellular Matrix Remodeling in Aqueous Humor and Tenon's Tissue From Primary Glaucoma Patients. 61
31725165 2019
18
Role of matrix metalloproteinase-9 gene polymorphisms in glaucoma: A hospital-based study in Chinese patients. 61
31713905 2019
19
Association of glaucoma with risk of retinal vein occlusion: A meta-analysis. 61
31125174 2019
20
Heritability of glaucoma and glaucoma-related endophenotypes: Systematic review and meta-analysis. 61
31229521 2019
21
The Chinese Glaucoma Study Consortium for Patients With Glaucoma: Design, Rationale and Baseline Patient Characteristics. 61
31567910 2019
22
Phacoemulsification, visco-goniosynechialysis, and goniotomy in patients with primary angle-closure glaucoma: A comparative study. 61
31578887 2019
23
Mitomycin C-augmented Phacotrabeculectomy Versus Phacoemulsification in Primary Angle-closure Glaucoma: A Randomized Controlled Study. 61
31469675 2019
24
24-hour Intraocular pressure monitoring: the way ahead. 61
31915728 2019
25
Intra-Operative Ostial Irido-Zonulo-Hyaloido-Vitrectomy with Primary Posterior Capsulectomy for Prevention of Post-Operative Aqueous Misdirection in Combined Phaco-Trabeculectomy in Primary Angle Closure Glaucoma. 61
31136195 2019
26
Correlation of iris collagen and in-vivo anterior segment structures in patients in different stages of chronic primary angle-closure in both eyes. 61
31546499 2019
27
One-month IOP in mitomycin C-augmented trabeculectomy can predict long-term IOP control in chronic primary angle-closure glaucoma. 61
30675681 2019
28
Relationship between ocular biometry and severity of primary angle-closure glaucoma: relevance for predictive, preventive, and personalized medicine. 61
31462943 2019
29
Intraocular pressure reduction in a spectrum of angle closure disease following cataract extraction. 61
31436187 2019
30
Detection of Proteins Associated with Extracellular Matrix Regulation in the Aqueous Humour of Patients with Primary Glaucoma. 61
30994369 2019
31
Morphological features of parapapillary beta zone and gamma zone in chronic primary angle-closure glaucoma. 61
31406353 2019
32
[Proteomic analysis of aqueous humor in acute primary angle-closure glaucoma]. 61
31495154 2019
33
Altered effective connectivity of primary visual cortex in primary angle closure glaucoma using Granger causality analysis. 61
31390872 2019
34
Frequency-specific oscillations synchronization in primary angle-closure glaucoma. 61
31475845 2019
35
Association of TNF-α gene alterations (c.-238G>A, c.-308G>A, c.-857C>T, c.-863C>A) with primary glaucoma in north Indian cohort. 61
31132515 2019
36
Optimization of surgical protocol for laser iridotomy based on the numerical simulation of aqueous flow. 61
31698619 2019
37
HLA-DPA1 gene polymorphism in primary glaucoma. 61
31389567 2019
38
Effect of Preoperative Factor on Intraocular Pressure after Phacoemulsification in Primary Open-angle Glaucoma and Primary Angle-closure Glaucoma. 61
31389206 2019
39
Possible role of differentially expressing novel protein markers (ligatin and fibulin-7) in human aqueous humor and trabecular meshwork tissue in glaucoma progression. 61
30958601 2019
40
Cost-effectiveness and cost-utility of population-based glaucoma screening in China: a decision-analytic Markov model. 61
31122906 2019
41
Effects of Different Body Postures on the Intraocular Pressure in Patients with Primary Angle-Closure Disease. 61
31274735 2019
42
Rare variants in novel and known genes associated with primary angle closure glaucoma based on whole exome sequencing of 549 probands. 61
31377238 2019
43
Automated Iris Segmentation from Anterior Segment OCT Images with Occludable Angles via Local Phase Tensor. 61
31946922 2019
44
Efficacy of Phacoemulsification Alone vs Phacoemulsification With Goniosynechialysis in Patients With Primary Angle-Closure Disease: A Randomized Clinical Trial. 61
31294768 2019
45
Diagnostic Accuracy of Van Herick Technique to Detect Pre-Disease States of Primary Angle Closure Glaucoma in a Resource Constraint Region. 61
30616435 2019
46
Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction. 61
31258822 2019
47
Blood Levels of Tumor Necrosis Factor Alpha and Its Type 2 Receptor Are Elevated in Patients with Boston Type I Keratoprosthesis. 61
30632412 2019
48
Novel inflammatory cytokines (IL-36, 37, 38) in the aqueous humor from patients with chronic primary angle closure glaucoma. 61
30901679 2019
49
[Preliminary efficacy of penetrating canaloplasty in primary angle-closure glaucoma]. 61
31189275 2019
50
Appositional angle closure and conversion of primary angle closure into glaucoma after laser peripheral iridotomy. 61
31160423 2019
Sources

Variations for Primary Angle-Closure Glaucoma

About this section
Sources

Expression for Primary Angle-Closure Glaucoma

About this section
Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.
Sources

Pathways for Primary Angle-Closure Glaucoma

About this section

Pathways related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Syndecan-1-mediated signaling events 1
10.19 MMP9 HGF
2
Tropisetron Pathway, Pharmacokinetics/Pharmacodynamics 60
Show member pathways
 9.83 HTR3D HTR3C
Sources

GO Terms for Primary Angle-Closure Glaucoma

About this section

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of reactive oxygen species metabolic process GO:2000377 8.96 PARL CYP1B1
2 serotonin receptor signaling pathway GO:0007210 8.62 HTR3D HTR3C

Molecular functions related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.26 PRSS56 PARL MMP9 HGF
2 serotonin-gated cation-selective channel activity GO:0022850 8.62 HTR3D HTR3C
Sources

Sources for Primary Angle-Closure Glaucoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....