MCID: PRM025
MIFTS: 31

Primary Bacterial Infectious Disease

Categories: Infectious diseases

Aliases & Classifications for Primary Bacterial Infectious Disease

MalaCards integrated aliases for Primary Bacterial Infectious Disease:

Name: Primary Bacterial Infectious Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050338

Summaries for Primary Bacterial Infectious Disease

Disease Ontology : 12 A bacterial infectious disease that results in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.

MalaCards based summary : Primary Bacterial Infectious Disease is related to chancroid and ehrlichiosis. An important gene associated with Primary Bacterial Infectious Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include lung, heart and bone, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Primary Bacterial Infectious Disease

Diseases related to Primary Bacterial Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 884)
# Related Disease Score Top Affiliating Genes
1 chancroid 33.2 CD40LG CD4 CCR6
2 ehrlichiosis 33.2 IL10 CD8A CD40LG CD4
3 bartonellosis 33.2 CRP CD40LG CD4
4 macs syndrome 33.2 TNF IL10 IFNG CD8A CD4
5 spotted fever 33.2 TNF IL10 IFNG CD40LG
6 epidemic typhus 33.1 TLR2 CRP CD8A CD40LG CD4
7 syphilis 33.1 CRP CD8A CD40LG CD4 CCR6 ALB
8 paratyphoid fever 33.1 TNF IFNG CRP
9 tularemia 33.1 TNF TLR2 IL6 CD8A CD40LG CD4
10 relapsing fever 33.1 TNF CRP CFHR2
11 legionellosis 33.1 TNF TLR2 IL6 CD40LG
12 melioidosis 33.1 TNF TLR2 IL6 IL10 IFNG
13 q fever 33.1 TNF TLR2 IL6 IL10 IFNG CD40LG
14 diphtheria 33.1 TNF IL2 IFNG CD40LG ALB
15 lyme disease 33.1 TNF TLR2 IL6 CRP CFHR2 CD40LG
16 typhoid fever 33.1 TNF IL6 IFNG CRP CD40LG CCR6
17 plague 33.1 TNF TLR2 IL6 IL10 CD8A CD4
18 brucellosis 33.1 TNF IL6 IL2 IL10 IFNG CRP
19 leptospirosis 33.0 TNF TLR2 IL6 IL2 IL10 IFNG
20 salmonellosis 33.0 TNF TLR2 IL6 IL10 IFNG CD8A
21 tetanus 33.0 TNF IL6 IL2 IL10 IFNG CRP
22 listeriosis 33.0 TNF TLR2 IL6 IL2 IL10 ICOSLG
23 shigellosis 32.9 TNF IL10 ALB
24 leprosy 3 32.9 TNF TLR2 IL6 IL2 IL10 IFNG
25 mycobacterium tuberculosis 1 32.9 TNF TLR2 SERPINA3 MIR21 MIR155 MIR144
26 buruli ulcer 11.3
27 erysipeloid 11.3
28 foodborne botulism 11.3
29 sennetsu fever 11.3
30 pinta disease 11.3
31 yaws 11.3
32 pasteurellosis 11.3
33 trench fever 11.3
34 ornithosis 11.3
35 rhinoscleroma 11.3
36 sodoku disease 11.3
37 haverhill fever 11.3
38 bejel 11.3
39 glanders 11.3
40 campylobacteriosis 11.3
41 cholera 11.3
42 anthrax disease 11.3
43 granuloma inguinale 11.3
44 staphyloenterotoxemia 11.3
45 coccidioidomycosis 10.9 CD40LG CD4 CCR6
46 syphilitic meningitis 10.9 CD8A CD40LG CD4
47 riedel's fibrosing thyroiditis 10.9 CD40LG CD4 ALB
48 encephalitis 10.9 TNF IL6 IL10 CD40LG
49 gastritis 10.9 TNF IL6 IL10 CCR6
50 autoimmune glomerulonephritis 10.9 ICOSLG CD8A CD4 CCR6

Graphical network of the top 20 diseases related to Primary Bacterial Infectious Disease:



Diseases related to Primary Bacterial Infectious Disease

Symptoms & Phenotypes for Primary Bacterial Infectious Disease

MGI Mouse Phenotypes related to Primary Bacterial Infectious Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 ALB CCR6 CD40LG CRP IFNG IL10
2 endocrine/exocrine gland MP:0005379 9.96 ALB CD4 CD40LG CD8A IFNG IL10
3 immune system MP:0005387 9.93 ALB CCR6 CD4 CD40LG CD8A CRP
4 digestive/alimentary MP:0005381 9.92 ALB CD4 IFNG IL10 IL2 IL6
5 integument MP:0010771 9.61 CD4 CD40LG CD8A IFNG IL10 IL6
6 neoplasm MP:0002006 9.17 ALB IFNG IL10 IL2 IL6 TLR2

Drugs & Therapeutics for Primary Bacterial Infectious Disease

Search Clinical Trials , NIH Clinical Center for Primary Bacterial Infectious Disease

Genetic Tests for Primary Bacterial Infectious Disease

Anatomical Context for Primary Bacterial Infectious Disease

MalaCards organs/tissues related to Primary Bacterial Infectious Disease:

40
Lung, Heart, Bone, Thyroid, Skin, B Cells, Kidney

Publications for Primary Bacterial Infectious Disease

Variations for Primary Bacterial Infectious Disease

Expression for Primary Bacterial Infectious Disease

Search GEO for disease gene expression data for Primary Bacterial Infectious Disease.

Pathways for Primary Bacterial Infectious Disease

Pathways related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 TNF TLR2 SERPINA3 IL6 IL2 IL10
2
Show member pathways
13.44 TNF TLR2 IL6 IL2 IL10 CD40LG
3
Show member pathways
13.33 TNF IL6 IL2 IL10 CD40LG CD4
4
Show member pathways
12.83 TNF IL6 IL2 IL10 IFNG ICOSLG
5
Show member pathways
12.73 TNF TLR2 IL6 IL2 CD40LG
6
Show member pathways
12.65 TNF IL2 IL10 IFNG ICOSLG CD40LG
7
Show member pathways
12.61 TNF TLR2 IL6 IL2 IL10 IFNG
8
Show member pathways
12.6 TNF IL6 IL2 IL10 IFNG CD4
9 12.57 TNF TLR2 IL2 IL10 IFNG CD8A
10
Show member pathways
12.52 TNF TLR2 IL6 IL2 IL10 IFNG
11
Show member pathways
12.37 IL6 IL2 IL10 IFNG
12 12.36 TNF IL6 IL2 CD4
13
Show member pathways
12.36 TNF IL6 IL2 IL10 CCR6
14
Show member pathways
12.35 TNF TLR2 IL6 IFNG
15
Show member pathways
12.33 TNF SERPINA3 IL6 IL2 IFNG CRP
16
Show member pathways
12.29 TNF IL6 IL2 IL10 IFNG
17
Show member pathways
12.28 TNF TLR2 IL10 IFNG CD40LG
18
Show member pathways
12.25 TNF IL6 IL2 IL10
19 12.25 TNF TLR2 IL6 IL10 IFNG
20 12.22 TNF TLR2 IL6 IFNG
21
Show member pathways
12.22 TNF TLR2 IL6 IFNG
22 12.15 ICOSLG CD8A CD40LG CD4
23
Show member pathways
12.07 TNF TLR2 IL6 IFNG
24
Show member pathways
12.06 TNF TLR2 IL6 IL2 IL10 IFNG
25 12.04 TNF IL6 IL2 IL10
26 12.04 TNF IL6 IL2 IFNG
27
Show member pathways
12 IL2 IFNG CD8A CD4
28 11.98 TNF IL6 IL2 IL10 IFNG CD8A
29 11.94 TNF TLR2 IL6 IL10 IFNG
30 11.93 IL6 IL2 IL10 IFNG
31 11.93 TNF IL6 CD8A CD4
32 11.9 TNF TLR2 IL6 IFNG
33
Show member pathways
11.79 TNF IL2 IFNG CD40LG
34 11.78 TNF IL6 IL10
35 11.74 TNF IL6 IL2 IL10 IFNG
36
Show member pathways
11.67 TNF IL2 IFNG CD8A
37
Show member pathways
11.67 TNF IL6 IL2 IFNG CD40LG
38 11.64 TNF TLR2 IL6
39 11.61 IL10 CD40LG CD4
40 11.6 TNF IL2 IL10 IFNG CD8A CD4
41 11.58 TNF IL6 IL2 IFNG
42 11.57 TNF IL6 IL10
43 11.55 TNF TLR2 IFNG
44 11.55 TNF IL2 IFNG
45 11.53 IL2 IL10 IFNG CD4
46 11.52 TNF IL6 IFNG
47 11.43 CD8A CD40LG CD4
48 11.43 TNF IL6 IL10 IFNG
49 11.43 TNF TLR2 IL6 IL10 IFNG CD40LG
50 11.39 TNF IL6 IL10

GO Terms for Primary Bacterial Infectious Disease

Cellular components related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 TNF SERPINA3 IL6 IL2 IL10 IFNG
2 external side of plasma membrane GO:0009897 9.43 TNF ICOSLG CD8A CD40LG CD4 CCR6
3 extracellular space GO:0005615 9.4 TNF SERPINA3 MIR21 MIR155 MIR144 IL6

Biological processes related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.08 MIR21 IL6 IL2 IL10 CD40LG ALB
2 cytokine-mediated signaling pathway GO:0019221 10 TNF IL6 IL2 IL10 CD4
3 cellular response to lipopolysaccharide GO:0071222 9.95 TNF MIR21 IL6 IL10
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 TNF TLR2 IL6 CD40LG
5 positive regulation of gene expression GO:0010628 9.87 TNF TLR2 MIR21 MIR155 IL6 IFNG
6 defense response to Gram-positive bacterium GO:0050830 9.85 TNF TLR2 IL6 CRP
7 positive regulation of protein phosphorylation GO:0001934 9.85 TNF MIR21 IL2 IFNG CD4
8 response to glucocorticoid GO:0051384 9.84 TNF IL6 IL10
9 positive regulation of interleukin-6 production GO:0032755 9.83 TNF TLR2 IL6
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.81 TNF MIR21 IL10
11 T cell activation GO:0042110 9.81 ICOSLG CD8A CD4
12 inflammatory response GO:0006954 9.8 TNF TLR2 SERPINA3 IL6 IL10 CRP
13 acute-phase response GO:0006953 9.79 SERPINA3 IL6 CRP
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 TNF IL6 IL2 IFNG
15 positive regulation of interleukin-6 secretion GO:2000778 9.77 TNF TLR2 MIR144
16 positive regulation of JAK-STAT cascade GO:0046427 9.74 TNF IL6 IL10
17 microglial cell activation GO:0001774 9.73 TNF TLR2 IFNG
18 positive regulation of T cell proliferation GO:0042102 9.73 IL6 IL2 CD40LG CD4
19 positive regulation of interleukin-12 production GO:0032735 9.71 TLR2 IFNG CD40LG
20 humoral immune response GO:0006959 9.71 TNF IL6 IFNG CCR6
21 negative regulation of amyloid-beta clearance GO:1900222 9.67 TNF IFNG
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL10 IFNG
23 negative regulation of interleukin-8 production GO:0032717 9.67 MIR155 IL10
24 positive regulation of chemokine production GO:0032722 9.67 TNF TLR2 IL6
25 endothelial cell apoptotic process GO:0072577 9.66 TNF IL10
26 negative regulation of regulatory T cell differentiation GO:0045590 9.65 MIR21 MIR155
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 TNF IL10
28 negative regulation of bicellular tight junction assembly GO:1903347 9.63 TNF MIR155
29 regulation of immunoglobulin secretion GO:0051023 9.62 TNF CD40LG
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IFNG
31 receptor biosynthetic process GO:0032800 9.58 TNF IL10
32 negative regulation of lipid storage GO:0010888 9.54 TNF IL6 CRP
33 positive regulation of vitamin D biosynthetic process GO:0060557 9.52 TNF IFNG
34 positive regulation of nitrogen compound metabolic process GO:0051173 9.51 TNF IFNG
35 positive regulation of activated T cell proliferation GO:0042104 9.46 MIR21 MIR155 IL2 ICOSLG
36 positive regulation of inflammatory response GO:0050729 9.43 TNF TLR2 MIR21 MIR155 MIR144 IL2
37 immune response GO:0006955 9.32 TNF TLR2 IL6 IL2 IL10 IFNG

Molecular functions related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL6 IL2 IL10 IFNG CD40LG

Sources for Primary Bacterial Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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