MCID: PRM025
MIFTS: 35

Primary Bacterial Infectious Disease

Categories: Infectious diseases

Aliases & Classifications for Primary Bacterial Infectious Disease

MalaCards integrated aliases for Primary Bacterial Infectious Disease:

Name: Primary Bacterial Infectious Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050338

Summaries for Primary Bacterial Infectious Disease

Disease Ontology : 12 A bacterial infectious disease that results in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.

MalaCards based summary : Primary Bacterial Infectious Disease is related to trench fever and salmonellosis. An important gene associated with Primary Bacterial Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include lung, brain and bone, and related phenotypes are growth/size/body region and cellular

Related Diseases for Primary Bacterial Infectious Disease

Diseases related to Primary Bacterial Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 trench fever 32.3 TLR2 TNF
2 salmonellosis 32.2 IFNG IL1B SLC11A1
3 diphtheria 32.2 EEF2 HBEGF IL2
4 legionellosis 32.2 IL1B TLR2 TNF
5 campylobacteriosis 32.1 IFNG IL1B SLC11A1
6 buruli ulcer 32.1 IFNG IL10 IL4 SLC11A1
7 melioidosis 32.1 IFNG IL10 TLR2 TNF
8 typhoid fever 32.1 IFNG IL1B SLC11A1 TNF
9 lyme disease 32.0 HSPD1 IL1B TLR2 TNF
10 tularemia 32.0 PDE6B SLC11A1 TLR2
11 leptospirosis 32.0 IFNG IL10 IL1B TLR2 TNF
12 brucellosis 32.0 IFNG IL10 IL2 IL4 SLC11A1 TNF
13 tetanus 32.0 IFNG IL10 IL2 IL4 VAMP2
14 spotted fever 32.0 IFNG IL10 TNF
15 q fever 31.9 IFNG IL10 IL1B IL4 TLR2 TNF
16 leprosy 3 31.8 HSPD1 IFNG IL10 IL2 IL4 SLC11A1
17 mycobacterium tuberculosis 1 31.7 HSPD1 IFNG IL10 IL4 INHA MFRP
18 macs syndrome 11.1
19 erysipeloid 11.1
20 foodborne botulism 11.1
21 epidemic typhus 11.1
22 sennetsu fever 11.1
23 pinta disease 11.1
24 ehrlichiosis 11.1
25 yaws 11.1
26 pasteurellosis 11.1
27 bartonellosis 11.1
28 ornithosis 11.1
29 rhinoscleroma 11.1
30 listeriosis 11.1
31 sodoku disease 11.1
32 shigellosis 11.1
33 relapsing fever 11.1
34 haverhill fever 11.1
35 bejel 11.1
36 glanders 11.1
37 chancroid 11.1
38 cholera 11.1
39 paratyphoid fever 11.1
40 plague 11.1
41 syphilis 11.1
42 anthrax disease 11.1
43 granuloma inguinale 11.1
44 staphyloenterotoxemia 11.1
45 fusariosis 10.4 EEF2 IFNG
46 variola major 10.4 IFNG IL2
47 far eastern spotted fever 10.4 HSPD1 IFNG
48 oral tuberculosis 10.4 IL2 TNF
49 cephalosporin allergy 10.4 IFNG IL10
50 eye lymphoma 10.4 IL10 TLR9

Graphical network of the top 20 diseases related to Primary Bacterial Infectious Disease:



Diseases related to Primary Bacterial Infectious Disease

Symptoms & Phenotypes for Primary Bacterial Infectious Disease

MGI Mouse Phenotypes related to Primary Bacterial Infectious Disease:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 DPT EEF2 HBEGF HSPD1 IFNG IL10
2 cellular MP:0005384 10.28 EEF2 EXTL3 HSPD1 IFNG IL10 IL2
3 homeostasis/metabolism MP:0005376 10.27 EXTL3 HBEGF IFNG IL10 IL1B IL2
4 hematopoietic system MP:0005397 10.26 IFNG IL10 IL1B IL2 IL4 INHA
5 mortality/aging MP:0010768 10.22 EEF2 EXTL3 HBEGF HSPD1 IFNG IL10
6 digestive/alimentary MP:0005381 10.18 IFNG IL10 IL2 IL4 INHA SLC11A1
7 immune system MP:0005387 10.17 IFNG IL10 IL1B IL2 IL4 INHA
8 endocrine/exocrine gland MP:0005379 10.16 EXTL3 IFNG IL10 IL2 IL4 INHA
9 integument MP:0010771 10.06 DPT HBEGF IFNG IL10 IL1B IL4
10 liver/biliary system MP:0005370 9.91 IFNG IL10 IL2 IL4 INHA TLR2
11 nervous system MP:0003631 9.9 HBEGF HSPD1 IFNG IL10 IL1B IL4
12 neoplasm MP:0002006 9.86 IFNG IL10 IL1B IL2 INHA SLC11A1
13 respiratory system MP:0005388 9.5 HBEGF IFNG IL10 IL2 IL4 TLR2
14 vision/eye MP:0005391 9.23 DPT IFNG IL10 IL2 IL4 MFRP

Drugs & Therapeutics for Primary Bacterial Infectious Disease

Search Clinical Trials , NIH Clinical Center for Primary Bacterial Infectious Disease

Genetic Tests for Primary Bacterial Infectious Disease

Anatomical Context for Primary Bacterial Infectious Disease

MalaCards organs/tissues related to Primary Bacterial Infectious Disease:

41
Lung, Brain, Bone, Heart, Lymph Node, Eye, T Cells

Publications for Primary Bacterial Infectious Disease

Variations for Primary Bacterial Infectious Disease

Expression for Primary Bacterial Infectious Disease

Search GEO for disease gene expression data for Primary Bacterial Infectious Disease.

Pathways for Primary Bacterial Infectious Disease

Pathways related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 EEF2 HBEGF IFNG IL10 IL1B IL2
2
Show member pathways
13.42 IL10 IL1B IL2 IL4 TLR2 TLR9
3
Show member pathways
13.37 HBEGF IFNG IL10 IL1B IL2 IL4
4
Show member pathways
13.27 HBEGF IFNG IL1B IL2 IL4 TLR2
5
Show member pathways
13.07 IFNG IL10 IL1B IL2 TLR2 TLR9
6
Show member pathways
12.94 HSPD1 IFNG IL10 IL1B IL2 IL4
7
Show member pathways
12.84 IFNG IL1B IL2 IL4 TLR2 TLR9
8
Show member pathways
12.73 IL1B IL2 TLR2 TLR9 TNF
9
Show member pathways
12.66 IFNG IL10 IL2 IL4 TNF
10
Show member pathways
12.63 IFNG IL10 IL1B IL2 TNF
11
Show member pathways
12.63 IFNG IL10 IL1B IL2 IL4 TLR2
12 12.57 IFNG IL10 IL1B IL2 IL4 TLR2
13
Show member pathways
12.48 IFNG IL10 IL1B IL2 IL4 TNF
14
Show member pathways
12.4 IFNG IL1B IL2 IL4 TNF
15
Show member pathways
12.4 IFNG IL1B IL4 TLR2 TNF
16
Show member pathways
12.31 IFNG IL10 IL1B IL4 TLR2 TNF
17
Show member pathways
12.29 IL10 IL1B IL2 TLR9 TNF
18
Show member pathways
12.28 HBEGF IFNG IL10 IL1B IL2 IL4
19 12.25 HSPD1 IL10 IL1B TNF VAMP2
20 12.22 IFNG TLR2 TLR9 TNF
21 12.2 HSPD1 IFNG IL10 IL1B TLR2 TLR9
22
Show member pathways
12.19 IFNG IL1B IL4 TLR2 TLR9 TNF
23
Show member pathways
12.11 IFNG IL10 IL1B IL2 IL4
24
Show member pathways
12.08 IL1B IL2 TLR2 TLR9
25 12.07 IFNG IL1B IL2 IL4 TNF
26 12.05 IFNG IL10 IL2 IL4 TNF
27
Show member pathways
12.05 HSPD1 IFNG IL1B IL4 TLR2 TNF
28 12.04 IL10 IL1B IL4 TNF
29
Show member pathways
12.04 IFNG IL1B IL2 IL4
30 11.95 IFNG IL10 IL1B TLR2 TNF
31 11.93 IFNG IL1B TLR2 TNF
32 11.89 IL1B IL4 TNF
33
Show member pathways
11.84 IFNG IL2 IL4 TNF
34 11.81 IFNG IL2 IL4
35
Show member pathways
11.81 IFNG IL10 IL1B IL2 TLR2 TLR9
36
Show member pathways
11.79 EEF2 HBEGF VAMP2
37 11.77 IL10 IL1B TNF
38
Show member pathways
11.75 IFNG IL1B IL2 TNF
39 11.75 IFNG IL10 IL1B IL2 IL4 TNF
40 11.69 IL1B IL4 TNF
41 11.68 HSPD1 IL1B TLR2 TNF
42
Show member pathways
11.67 IFNG IL2 TNF
43 11.67 IFNG IL10 IL1B IL2 TLR9 TNF
44 11.64 HBEGF IFNG IL2 TNF
45 11.62 IL10 IL1B IL4 TNF
46 11.6 IFNG IL1B IL2 TNF
47 11.6 IFNG IL1B TLR2 TNF
48 11.59 IFNG IL10 IL1B IL2 IL4 TNF
49 11.57 IFNG IL10 IL2 IL4
50 11.53 IFNG IL1B TNF

GO Terms for Primary Bacterial Infectious Disease

Cellular components related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 DPT EEF2 HBEGF IFNG IL10 IL1B
2 membrane raft GO:0045121 9.46 EEF2 HSPD1 TLR2 TNF
3 extracellular space GO:0005615 9.32 DPT HBEGF HSPD1 IFNG IL10 IL1B

Biological processes related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.99 IFNG IL1B IL2 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 IL1B TLR2 TLR9 TNF
3 response to lipopolysaccharide GO:0032496 9.91 HSPD1 IL10 IL1B SLC11A1 TLR2
4 response to organic substance GO:0010033 9.9 HSPD1 IL10 TNF
5 positive regulation of JNK cascade GO:0046330 9.89 IL1B TLR9 TNF
6 positive regulation of cell growth GO:0030307 9.89 EXTL3 HBEGF IL2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 IFNG IL2 IL4
8 regulation of insulin secretion GO:0050796 9.88 IFNG IL1B TNF
9 positive regulation of T cell proliferation GO:0042102 9.87 IL1B IL2 IL4
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 IFNG IL1B TNF
11 response to glucocorticoid GO:0051384 9.84 HSPD1 IL10 IL1B TNF
12 positive regulation of JUN kinase activity GO:0043507 9.81 IL1B TLR9 TNF
13 positive regulation of B cell proliferation GO:0030890 9.81 IL2 IL4 TLR9
14 positive regulation of phagocytosis GO:0050766 9.8 IL1B SLC11A1 TNF
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 IL1B TLR2 TNF
16 positive regulation of inflammatory response GO:0050729 9.8 HSPD1 IL2 TLR2 TLR9 TNF
17 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.79 HSPD1 TLR2 TLR9
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 IL1B TLR2 TLR9 TNF
19 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 TLR9 TNF
20 regulation of signaling receptor activity GO:0010469 9.76 HBEGF IFNG IL10 IL1B IL2 IL4
21 positive regulation of interleukin-10 production GO:0032733 9.75 HSPD1 TLR2 TLR9
22 positive regulation of chemokine production GO:0032722 9.74 TLR2 TLR9 TNF
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR2 TLR9
24 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR2 TLR9 TNF
25 regulation of cytokine secretion GO:0050707 9.72 TLR2 TLR9
26 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR9
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG IL1B TNF
28 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B TLR9
29 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR9 TNF
30 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 IL2 IL4
31 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
34 negative regulation of interleukin-8 production GO:0032717 9.69 IL10 TLR9
35 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 IL10 IL4
36 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
37 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
38 positive regulation of neuroinflammatory response GO:0150078 9.68 IL1B TNF
39 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
40 positive regulation of interleukin-18 production GO:0032741 9.67 TLR2 TLR9
41 tumor necrosis factor production GO:0032640 9.67 TLR2 TLR9
42 response to molecule of bacterial origin GO:0002237 9.67 IL10 TLR2 TLR9
43 positive regulation of interleukin-12 production GO:0032735 9.67 HSPD1 IFNG TLR2 TLR9
44 chronic inflammatory response to antigenic stimulus GO:0002439 9.66 IL1B TNF
45 positive regulation of toll-like receptor signaling pathway GO:0034123 9.65 TLR2 TLR9
46 regulation of isotype switching GO:0045191 9.65 IL10 IL4
47 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
48 positive regulation of interleukin-6 production GO:0032755 9.65 HSPD1 IL1B TLR2 TLR9 TNF
49 type 2 immune response GO:0042092 9.64 IL10 IL4
50 receptor biosynthetic process GO:0032800 9.62 IL10 TNF

Molecular functions related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 HBEGF IL10 IL2 IL4 INHA
2 interleukin-1 receptor binding GO:0005149 9.26 IL1B TLR9
3 cytokine activity GO:0005125 9.17 IFNG IL10 IL1B IL2 IL4 INHA
4 signaling pattern recognition receptor activity GO:0008329 9.16 TLR2 TLR9

Sources for Primary Bacterial Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....