MCID: PRM025
MIFTS: 31

Primary Bacterial Infectious Disease

Categories: Infectious diseases

Aliases & Classifications for Primary Bacterial Infectious Disease

MalaCards integrated aliases for Primary Bacterial Infectious Disease:

Name: Primary Bacterial Infectious Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050338

Summaries for Primary Bacterial Infectious Disease

Disease Ontology : 12 A bacterial infectious disease that results in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.

MalaCards based summary : Primary Bacterial Infectious Disease is related to trench fever and syphilis. An important gene associated with Primary Bacterial Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotypes are cellular and growth/size/body region

Related Diseases for Primary Bacterial Infectious Disease

Diseases related to Primary Bacterial Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 trench fever 33.2 CD40LG TLR2 TNF
2 syphilis 33.2 CD40LG CD79A EXTL3
3 spotted fever 33.1 IFNG IL10 TNF
4 typhoid fever 33.1 IFNG SLC11A1 TNF
5 legionellosis 33.1 CD40LG TLR2 TNF
6 tularemia 33.0 PDE6B SLC11A1 TLR2
7 listeriosis 33.0 IL10 SUMF2 TNF
8 lyme disease 33.0 CD40LG HSPD1 TLR2 TNF
9 leptospirosis 33.0 CD40LG IL10 TLR2 TNF
10 melioidosis 33.0 IFNG IL10 TLR2 TNF
11 buruli ulcer 32.8 CD40LG IFNG IL10 IL4 SLC11A1
12 q fever 32.6 CD40LG CD79A IFNG IL10 TLR2 TNF
13 tetanus 32.5 CD40LG CD79A IFNG IL10 IL2 IL4
14 diphtheria 32.4 EEF2 HBEGF IL2
15 brucellosis 32.4 CD40LG IFNG IL10 IL2 IL4 SLC11A1
16 leprosy 3 31.7 CD40LG CD79A HSPD1 IFNG IL10 IL2
17 mycobacterium tuberculosis 1 31.5 HSPD1 IFNG IL10 IL4 INHA MFRP
18 selective igg deficiency disease 11.3 CD40LG CD79A
19 c1q nephropathy 11.3 CD40LG CD79A
20 oral tuberculosis 11.3 IL2 TNF
21 punctate inner choroidopathy 11.2 IL10 TNF
22 meningovascular neurosyphilis 11.2 CD40LG CD79A
23 alpha chain disease 11.2 CD40LG CD79A
24 brill-zinsser disease 11.2 CD40LG CD79A
25 early yaws 11.2 CD40LG CD79A EXTL3
26 exudative glomerulonephritis 11.2 CD40LG CD79A
27 cork-handlers' disease 11.2 CD40LG CD79A
28 ocular toxoplasmosis 11.2 CD40LG CD79A TLR9
29 congenital syphilis 11.2 CD40LG CD79A EXTL3
30 central nervous system vasculitis 11.2 CD40LG TLR9 TNF
31 salpingo-oophoritis 11.2 CD40LG CD79A
32 secondary syphilis 11.2 CD40LG CD79A EXTL3
33 mycoplasmal pneumonia 11.2 IFNG IL4
34 autoimmune myocarditis 11.2 IFNG IL2 TNF
35 chorioretinitis 11.2 CD40LG CD79A EXTL3
36 asymptomatic neurosyphilis 11.2 CD40LG CD79A EXTL3
37 ventilation pneumonitis 11.2 CD40LG CD79A
38 osteosclerotic myeloma 11.2 CD40LG CD79A TNF
39 chronic interstitial cystitis 11.2 CD40LG CD79A
40 cat-scratch disease 11.2 CD40LG HSPD1 IFNG
41 axillary adenitis 11.2 CD40LG CD79A
42 cryofibrinogenemia 11.2 CD40LG CD79A
43 jejunoileitis 11.2 CD40LG CD79A TNF
44 farmer's lung 11.2 CD79A IL2 TNF
45 acute salpingitis 11.2 CD40LG CD79A TNF
46 monoclonal gammopathy of uncertain significance 11.2 CD40LG CD79A TNF
47 fallopian tube disease 11.2 CD40LG CD79A HSPD1
48 neuroschistosomiasis 11.2 CD79A IFNG
49 autoimmune disease of urogenital tract 11.2 CD40LG CD79A TLR9
50 pneumocystosis 11.2 CD40LG CD79A TNF

Graphical network of the top 20 diseases related to Primary Bacterial Infectious Disease:



Diseases related to Primary Bacterial Infectious Disease

Symptoms & Phenotypes for Primary Bacterial Infectious Disease

MGI Mouse Phenotypes related to Primary Bacterial Infectious Disease:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 EEF2 IL10 EXTL3 CD40LG HSPD1 IFNG
2 growth/size/body region MP:0005378 10.29 DPT EEF2 IL10 HBEGF HSPD1 IFNG
3 homeostasis/metabolism MP:0005376 10.28 IL10 EXTL3 HBEGF CD40LG IFNG CD79A
4 hematopoietic system MP:0005397 10.23 IL10 CD40LG IFNG CD79A TLR9 TNF
5 digestive/alimentary MP:0005381 10.16 IL10 IFNG TLR9 TNF IL4 SLC11A1
6 endocrine/exocrine gland MP:0005379 10.15 IFNG EXTL3 CD40LG TNF TLR2 IL4
7 immune system MP:0005387 10.14 CD40LG CD79A IFNG TLR9 TNF TLR2
8 mortality/aging MP:0010768 10.13 EEF2 IL10 EXTL3 HBEGF CD40LG HSPD1
9 integument MP:0010771 10.02 DPT IL10 HBEGF CD40LG IFNG TNF
10 liver/biliary system MP:0005370 9.92 IL10 CD79A IFNG TNF TLR2 IL4
11 neoplasm MP:0002006 9.76 IL10 IFNG CD79A TNF SLC11A1 TLR2
12 nervous system MP:0003631 9.7 IFNG HBEGF HSPD1 CD40LG CD79A TNF
13 vision/eye MP:0005391 9.23 DPT IFNG TNF PDE6B IL4 IL10

Drugs & Therapeutics for Primary Bacterial Infectious Disease

Search Clinical Trials , NIH Clinical Center for Primary Bacterial Infectious Disease

Genetic Tests for Primary Bacterial Infectious Disease

Anatomical Context for Primary Bacterial Infectious Disease

Publications for Primary Bacterial Infectious Disease

Variations for Primary Bacterial Infectious Disease

Expression for Primary Bacterial Infectious Disease

Search GEO for disease gene expression data for Primary Bacterial Infectious Disease.

Pathways for Primary Bacterial Infectious Disease

Pathways related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CD40LG CD79A EEF2 HBEGF IFNG IL10
2
Show member pathways
13.34 CD40LG HBEGF IFNG IL10 IL2 IL4
3
Show member pathways
13 IFNG IL10 IL2 TLR2 TLR9 TNF
4
Show member pathways
12.88 CD40LG HSPD1 IFNG IL10 IL2 IL4
5
Show member pathways
12.8 CD79A IFNG IL2 IL4 TLR2 TLR9
6
Show member pathways
12.78 IFNG IL2 IL4 TLR2 TLR9 TNF
7
Show member pathways
12.69 CD40LG IL2 TLR2 TLR9 TNF
8
Show member pathways
12.63 IFNG IL10 IL2 IL4 TNF
9
Show member pathways
12.49 CD40LG TLR2 TLR9 TNF
10
Show member pathways
12.45 IFNG IL10 IL2 IL4 TLR2 TNF
11
Show member pathways
12.42 CD40LG IFNG IL10 IL2 IL4 TNF
12
Show member pathways
12.32 IFNG IL2 IL4 TNF
13
Show member pathways
12.32 IFNG IL4 TLR2 TNF
14
Show member pathways
12.25 IFNG IL10 IL2 TLR2 TLR9 TNF
15
Show member pathways
12.23 CD40LG IFNG IL10 IL4 TLR2 TNF
16
Show member pathways
12.2 IL10 IL2 TLR9 TNF
17
Show member pathways
12.2 IFNG IL4 TLR2 TLR9 TNF
18 12.17 IFNG TLR2 TLR9 TNF
19 12.13 HSPD1 IFNG IL10 TLR2 TLR9 TNF
20 12.01 IFNG IL2 IL4 TNF
21 11.89 IFNG IL10 TLR2 TNF
22 11.82 IFNG TLR2 TNF
23 11.8 CD79A IFNG IL10 IL2 IL4 TNF
24 11.79 CD40LG CD79A IFNG IL10 IL2 IL4
25 11.78 IFNG IL2 IL4
26 11.73 IFNG IL10 IL2 IL4 TNF
27
Show member pathways
11.69 CD40LG IFNG IL2 TNF
28 11.65 CD40LG IL10 IL4
29
Show member pathways
11.65 CD40LG IFNG IL2 IL4 TNF
30
Show member pathways
11.64 IFNG IL2 TNF
31 11.59 IFNG IL10 IL2 TLR9 TNF
32 11.58 HSPD1 TLR2 TNF
33 11.58 HBEGF IFNG IL2 TNF
34 11.52 IL10 IL4 TNF
35 11.52 IFNG IL10 IL2 IL4
36 11.5 IFNG IL2 TNF
37 11.49 IFNG TLR2 TNF
38 11.37 IFNG IL10 TLR9 TNF
39 11.33 CD40LG IFNG IL2 IL4
40 11.3 IFNG IL4 TNF
41 11.19 HBEGF IFNG TLR2
42 11.17 IFNG IL10 IL2 IL4
43 11.12 CD40LG IFNG IL10 TLR2 TLR9 TNF
44 11.03 IFNG IL10 IL2 IL4 TNF

GO Terms for Primary Bacterial Infectious Disease

Cellular components related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CD40LG EEF2 HBEGF IFNG IL10 IL2
2 membrane raft GO:0045121 9.46 CD79A EEF2 TLR2 TNF
3 extracellular space GO:0005615 9.36 CD40LG DPT HBEGF HSPD1 IFNG IL10

Biological processes related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.97 IL10 SLC11A1 TLR9 TNF
2 inflammatory response GO:0006954 9.97 CD40LG IL10 SLC11A1 TLR2 TLR9 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 CD40LG TLR2 TLR9 TNF
4 positive regulation of cell growth GO:0030307 9.85 EXTL3 HBEGF IL2
5 positive regulation of inflammatory response GO:0050729 9.85 IL2 TLR2 TLR9
6 positive regulation of T cell proliferation GO:0042102 9.83 CD40LG IL2 IL4
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 TLR2 TLR9 TNF
8 positive regulation of B cell proliferation GO:0030890 9.79 IL2 IL4 TLR9
9 B cell differentiation GO:0030183 9.76 CD40LG CD79A IL10 IL4
10 immune response GO:0006955 9.76 CD40LG IFNG IL10 IL2 IL4 SLC11A1
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.73 HSPD1 TLR2 TLR9
12 B cell activation GO:0042113 9.72 CD79A HSPD1 IL4
13 positive regulation of interleukin-8 production GO:0032757 9.71 TLR2 TLR9 TNF
14 positive regulation of interleukin-6 production GO:0032755 9.71 HSPD1 TLR2 TLR9 TNF
15 negative regulation of interleukin-6 production GO:0032715 9.7 IL10 TLR9 TNF
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL10 TNF
17 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR9
18 regulation of cytokine secretion GO:0050707 9.68 TLR2 TLR9
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.67 IL2 IL4
20 positive regulation of interferon-gamma production GO:0032729 9.67 HSPD1 IL2 SLC11A1 TNF
21 endothelial cell apoptotic process GO:0072577 9.66 IL10 TNF
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL10 IL4
23 positive regulation of chemokine production GO:0032722 9.65 TLR2 TLR9 TNF
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
25 type 2 immune response GO:0042092 9.64 IL10 IL4
26 negative regulation of interleukin-8 production GO:0032717 9.63 IL10 TLR9
27 regulation of immunoglobulin secretion GO:0051023 9.62 CD40LG TNF
28 B cell proliferation GO:0042100 9.62 CD40LG CD79A HSPD1 IL10
29 positive regulation of toll-like receptor signaling pathway GO:0034123 9.61 TLR2 TLR9
30 tumor necrosis factor production GO:0032640 9.61 TLR2 TLR9
31 response to molecule of bacterial origin GO:0002237 9.61 IL10 TLR2 TLR9
32 regulation of isotype switching GO:0045191 9.6 IL10 IL4
33 positive regulation of interleukin-18 production GO:0032741 9.59 TLR2 TLR9
34 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IFNG TNF
36 positive regulation of interleukin-10 production GO:0032733 9.56 CD40LG HSPD1 TLR2 TLR9
37 regulation of signaling receptor activity GO:0010469 9.56 CD40LG HBEGF IFNG IL10 IL2 IL4
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 IFNG TNF
39 positive regulation of interleukin-12 production GO:0032735 9.02 CD40LG HSPD1 IFNG TLR2 TLR9
40 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 IL10 IL2 IL4 SLC11A1 TLR2 TLR9
41 positive regulation of gene expression GO:0010628 10.04 IFNG SLC11A1 TLR2 TLR9 TNF

Molecular functions related to Primary Bacterial Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 HBEGF IL10 IL2 IL4 INHA
2 cytokine activity GO:0005125 9.17 CD40LG IFNG IL10 IL2 IL4 INHA

Sources for Primary Bacterial Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....