MCID: PRM006
MIFTS: 53

Primary Biliary Cirrhosis

Categories: Endocrine diseases, Gastrointestinal diseases, Immune diseases, Liver diseases

Aliases & Classifications for Primary Biliary Cirrhosis

MalaCards integrated aliases for Primary Biliary Cirrhosis:

Name: Primary Biliary Cirrhosis 38 12 76 37 15 73
Chronic Nonsuppurative Destructive Cholangitis 12
Biliary Cirrhosis Primary 55
Liver Cirrhosis, Biliary 44
Biliary Liver Cirrhosis 12
Cholestatic Cirrhosis 12
Biliary Cirrhosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12236
ICD10 33 K74.3 K74.5
ICD9CM 35 571.6
MeSH 44 D008105
SNOMED-CT 68 1761006 31712002
KEGG 37 H01467

Summaries for Primary Biliary Cirrhosis

Disease Ontology : 12 A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.

MalaCards based summary : Primary Biliary Cirrhosis, also known as chronic nonsuppurative destructive cholangitis, is related to systemic lupus erythematosus and primary biliary cholangitis. An important gene associated with Primary Biliary Cirrhosis is DLAT (Dihydrolipoamide S-Acetyltransferase), and among its related pathways/superpathways are MicroRNAs in cancer and Cell Differentiation - Index. The drugs Ursodeoxycholic acid and Abatacept have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and t cells.

Wikipedia : 76 Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune... more...

Related Diseases for Primary Biliary Cirrhosis

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 1 Biliary Cirrhosis, Primary, 2
Biliary Cirrhosis, Primary, 3 Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Primary Biliary Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 30.3 MIR150 MIR197 MIR346 MIR423 MIR494
2 primary biliary cholangitis 12.6
3 reynolds syndrome 12.5
4 biliary cirrhosis, primary, 1 12.3
5 biliary cirrhosis, primary, 2 11.4
6 biliary cirrhosis, primary, 3 11.4
7 biliary cirrhosis, primary, 4 11.4
8 biliary cirrhosis, primary, 5 11.4
9 hepatitis 10.9
10 autoimmune hepatitis 10.8
11 cholangitis 10.7
12 sclerosing cholangitis 10.6
13 cholangitis, primary sclerosing 10.6
14 hepatocellular carcinoma 10.6
15 liver disease 10.5
16 scleroderma, familial progressive 10.5
17 arthritis 10.5
18 rheumatoid arthritis 10.4
19 crest syndrome 10.4
20 renal tubular acidosis 10.4
21 hemolytic anemia 10.4
22 osteoporosis 10.4
23 hepatitis c 10.4
24 autoimmune disease 10.3
25 anemia, autoimmune hemolytic 10.3
26 sjogren syndrome 10.3
27 glomerulonephritis 10.3
28 lupus erythematosus 10.3
29 bone disease 10.3
30 thyroiditis 10.3
31 hepatitis b 10.3
32 lymphoma 10.3
33 portal hypertension 10.3
34 esophageal varix 10.3
35 cholestasis 10.3
36 purpura 10.3
37 connective tissue disease 10.3
38 nodular regenerative hyperplasia 10.3
39 pernicious anemia 10.2
40 pulmonary hypertension 10.2
41 osteomalacia 10.2
42 autoimmune disease 1 10.2
43 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
44 alcoholic liver cirrhosis 10.2
45 liver cirrhosis 10.2
46 pneumonia 10.2
47 polymyositis 10.2
48 multiple sclerosis 10.1
49 lichen sclerosus et atrophicus 10.1
50 celiac disease 1 10.1

Comorbidity relations with Primary Biliary Cirrhosis via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Cholangitis Deficiency Anemia
Hepatic Encephalopathy Hypothyroidism
Portal Hypertension

Graphical network of the top 20 diseases related to Primary Biliary Cirrhosis:



Diseases related to Primary Biliary Cirrhosis

Symptoms & Phenotypes for Primary Biliary Cirrhosis

Drugs & Therapeutics for Primary Biliary Cirrhosis

Drugs for Primary Biliary Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 136)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128-13-2 31401
2
Abatacept Approved Phase 4 332348-12-6 10237
3
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
4
Methionine Approved, Nutraceutical Phase 4,Phase 2 63-68-3 6137
5 Liver Extracts Phase 4,Phase 3,Phase 2,Not Applicable
6 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Immunosuppressive Agents Phase 4,Phase 3,Not Applicable
11 Cathartics Phase 4,Phase 3,Phase 2,Early Phase 1
12 Laxatives Phase 4,Phase 3,Phase 2,Early Phase 1
13
Fenofibrate Approved Phase 3,Phase 1,Phase 2 49562-28-9 3339
14
Bezafibrate Approved, Investigational Phase 3 41859-67-0 39042
15
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
16
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
17
Copper Approved, Investigational Phase 3 7440-50-8 27099
18
Molybdenum Approved Phase 3 7439-98-7 185498
19
Colchicine Approved Phase 3 64-86-8 6167 2833
20
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
21
leucovorin Approved Phase 3 58-05-9 6006 143
22
Budesonide Approved Phase 3,Phase 1,Not Applicable 51333-22-3 63006 5281004
23
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
24
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
26
Tauroursodeoxycholic acid Experimental, Investigational Phase 3 14605-22-2 12443252
27 Lipid Regulating Agents Phase 3,Phase 1,Phase 2
28 Antimetabolites Phase 3,Phase 1,Phase 2
29 Hypolipidemic Agents Phase 3,Phase 1,Phase 2
30 Anti-Retroviral Agents Phase 2, Phase 3,Not Applicable
31 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
32 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Not Applicable
33 Anti-HIV Agents Phase 2, Phase 3,Not Applicable
34 Antiviral Agents Phase 2, Phase 3,Phase 3,Not Applicable
35 Lamivudine, zidovudine drug combination Phase 2, Phase 3
36 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
37 Taurochenodeoxycholic Acid Phase 3
38 Tetrathiomolybdate Phase 3
39 Trace Elements Phase 3,Not Applicable
40 Micronutrients Phase 3,Not Applicable
41 Chelating Agents Phase 3
42 Angiogenesis Modulating Agents Phase 3
43 Angiogenesis Inhibitors Phase 3
44 Atorvastatin Calcium Phase 3 134523-03-8
45 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
46 Calcium, Dietary Phase 3
47 Anticholesteremic Agents Phase 3,Phase 1
48 Folic Acid Antagonists Phase 3
49 Vitamin B Complex Phase 3
50 Vitamin B9 Phase 3

Interventional clinical trials:

(show top 50) (show all 114)
# Name Status NCT ID Phase Drugs
1 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
2 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Completed NCT02078882 Phase 4
3 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
4 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic
5 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
6 Study of OCA Evaluating Pharmacokinetics and Safety in Patients With PBC and Hepatic Impairment Recruiting NCT03633227 Phase 4 Obeticholic Acid (OCA);Placebo
7 Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Unknown status NCT02823353 Phase 3 Fenofibrate;UDCA
8 Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Unknown status NCT02916290 Phase 3 Fuzhenghuayu;UDCA
9 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Unknown status NCT02823366 Phase 3 Fenofibrate;UDCA
10 Fuzhenghuayu for Patients With PBC Who Had An Inadequate Response to Ursodeoxycholic Acid Unknown status NCT02916641 Phase 3 Fuzhenghuayu;UDCA
11 The Effect of Bezafibrate on Cholestatic Itch Unknown status NCT02701166 Phase 3 Bezafibrate;Placebo
12 Study of Combivir for Patients With Primary Biliary Cirrhosis Completed NCT00490620 Phase 2, Phase 3 Combination antiviral therapy;Placebo
13 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3 Tauroursodeoxycholic Acid Capsules;Ursodeoxycholic Acid Capsules
14 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3 Tetrathiomolybdate
15 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
16 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis Completed NCT00004748 Phase 3 colchicine;methotrexate;ursodiol
17 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3 Bezafibrate;placebo
18 Ursodiol-Methotrexate for Primary Biliary Cirrhosis Completed NCT00006168 Phase 3 Methotrexate
19 Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis Completed NCT00004784 Phase 3 methotrexate;ursodiol
20 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid
21 Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders Recruiting NCT02937012 Phase 3 Bezafibrate;Ursodeoxycholic Acid;Placebo (for Bezafibrate)
22 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) Recruiting NCT03301506 Phase 2, Phase 3 Seladelpar 2 mg Capsule;Seladelpar 5 mg Capsule;Seladelpar 10 mg Capsule
23 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA) Recruiting NCT03602560 Phase 3 seladelpar 5-10 mg;seladelpar 10 mg;Placebo
24 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Recruiting NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
25 Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis Active, not recruiting NCT01473524 Phase 3 Obeticholic Acid (OCA);Placebo
26 Metformin in Intrahepatic Cholestasis of Pregnancy Not yet recruiting NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
27 Ursodeoxycholic Acid Plus Budesonide Versus Ursodeoxycholic Acid Alone in Primary Biliary Cirrhosis (PBC) Terminated NCT00746486 Phase 3 budesonide;budesonide placebo
28 Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis Unknown status NCT01662973 Phase 1, Phase 2
29 Pilot Study of FFP104 Dose Escalation in PBC Subjects Unknown status NCT02193360 Phase 1, Phase 2 FFP104
30 Efficacy and Safety of Fenofibrate Combined With UDCA in PBC Patients With an Incomplete Biochemical Response to UDCA Unknown status NCT02965911 Phase 1, Phase 2 Fenofibrate;UDCA
31 Study of Rituximab in Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease Unknown status NCT00472225 Phase 2 Rituximab
32 Moexipril for Primary Biliary Cirrhosis Completed NCT00588302 Phase 2 Moexipril
33 Initial Study of Rituximab to Treat Primary Biliary Cirrhosis Completed NCT00364819 Phase 1, Phase 2 rituximab
34 Use of Fenofibrate for Primary Biliary Cirrhosis Completed NCT00575042 Phase 2 Fenofibrate IDD-P (Insoluble Drug Delivery-Micro Particle)
35 A Study of Efficacy and Safety of Ustekinumab in Patients With Primary Biliary Cirrhosis (PBC) Who Had an Inadequate Response to Ursodeoxycholic Acid Completed NCT01389973 Phase 2 ustekinumab 90 mg;ustekinumab 45 mg;ustekinumab 180 mg;Placebo
36 Phase 2b Study of NGM282 Extended Treatment in Patients With Primary Biliary Cirrhosis Completed NCT02135536 Phase 2
37 Phase 2 Study of NGM282 in Patients With Primary Biliary Cirrhosis Completed NCT02026401 Phase 2
38 Pentoxifylline for Primary Biliary Cirrhosis Completed NCT01249092 Phase 2 Pentoxifylline
39 B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis Completed NCT02376335 Phase 2
40 Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis Completed NCT01904058 Phase 2 LUM001;Placebo;Ursodeoxycholic Acid
41 Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Subjects With Primary Biliary Cirrhosis Completed NCT01865812 Phase 2 obeticholic acid (OCA)
42 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus Completed NCT01899703 Phase 2 GSK2330672;Placebo;Ursodeoxycholic acid
43 A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in PBC Patients Completed NCT02516605 Phase 2 Part 1: LJN452;Part 1: Placebo;Part 2: LJN452 Dose level 1;Part 2: Placebo;Part 2: LJN452 Dose level 2
44 Study of INT 747 in Combination With URSO in Patients With Primay Biliary Cirrhosis (PBC) Completed NCT00550862 Phase 2 INT-747;Ursodeoxycholic Acid (URSO);Placebo
45 Study of INT-747 as Monotherapy in Patients With PBC Completed NCT00570765 Phase 2 Placebo;INT-747;INT-747
46 Treatment of Cholestatic Pruritus With Sertraline Completed NCT00058903 Phase 2 sertraline
47 A Study to Evaluate Safety, Tolerability and Efficacy of Saroglitazar Magnesium in Patients With Primary Biliary Cholangitis (EPICS) Recruiting NCT03112681 Phase 2 Saroglitazar magnesium 2 mg;Saroglitazar magnesium 4 mg;Placebo Oral Tablet
48 Safety, Tolerability, and Efficacy of Etrasimod (APD334) in Patients With Primary Biliary Cholangitis Recruiting NCT03155932 Phase 2 APD334
49 A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis Recruiting NCT03394924 Phase 2 EDP-305 Dose 1;EDP-305 Dose 2;Placebo
50 Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) and Inadequate Response to Ursodeoxycholic Acid Recruiting NCT03124108 Phase 2 Elafibranor 80 mg;Elafibranor 120 mg;Placebo

Search NIH Clinical Center for Primary Biliary Cirrhosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Primary Biliary Cirrhosis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: liver cirrhosis, biliary

Genetic Tests for Primary Biliary Cirrhosis

Anatomical Context for Primary Biliary Cirrhosis

MalaCards organs/tissues related to Primary Biliary Cirrhosis:

41
Liver, T Cells, Bone, B Cells, Lung, Thyroid, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Primary Biliary Cirrhosis:
# Tissue Anatomical CompartmentCell Relevance
1 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Primary Biliary Cirrhosis

Articles related to Primary Biliary Cirrhosis:

(show top 50) (show all 1790)
# Title Authors Year
1
IgG4-related retroperitoneal fibrosis overlapping with primary biliary cirrhosis and primary SjAPgren's syndrome: A case report. ( 29953016 )
2018
2
Lower Plasma Levels of IL-35 in Patients with Primary Biliary Cirrhosis. ( 29445068 )
2018
3
Palmoplantar keratoderma as a presenting sign of primary biliary cirrhosis. ( 29270458 )
2018
4
Increased risk of osteoporosis in patients with primary biliary cirrhosis. ( 29543880 )
2018
5
Primary myelofibrosis but not autoimmune myelofibrosis accompanied by SjAPgren's syndrome and primary biliary cirrhosis in a patient with trisomy 8 mosaic: a case report and literature review. ( 29745886 )
2018
6
Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and SjAPgren syndrome: A case report. ( 29465536 )
2018
7
Primary biliary cirrhosis with refractory hypokalemia: A case report. ( 30508897 )
2018
8
Lp8 is potentially associated with partial lecithin:cholesterol acyltransferase deficiency in a patient with primary biliary cirrhosis. ( 30055975 )
2018
9
Morphea associated with primary biliary cirrhosis and Waldenstrom macroglobulinemia: Response to rituximab. ( 30246126 )
2018
10
IgM-Positive Tubulointerstitial Nephritis Associated With Asymptomatic Primary Biliary Cirrhosis. ( 29988993 )
2018
11
Primary Biliary Cholangitis (Primary Biliary Cirrhosis) ( 29083627 )
2017
12
Interstitial granulomatous dermatitis associated with primary biliary cirrhosis. ( 28225148 )
2017
13
Clinical relevance of combined anti-mitochondrial M2 detection assays for primary biliary cirrhosis. ( 27864100 )
2017
14
Successful infliximab therapy in a patient with comorbid spondyloarthritis, primary biliary cirrhosis and generalized morphea. ( 28229620 )
2017
15
Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis. ( 29113177 )
2017
16
Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury. ( 28823616 )
2017
17
A Case of Primary Biliary Cirrhosis Mimicking Acute Hepatitis B in the Clinic, Republic of Korea. ( 28197333 )
2017
18
Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. ( 28570655 )
2017
19
[Single nucleotide polymorphism of STAT4 rs7574865 is associated with the susceptibility of primary biliary cirrhosis in Han population of partial regions of Jiangsu province]. ( 28395724 )
2017
20
Xanthoma Striatum Palmare in a Patient of Primary Biliary Cirrhosis with Autoimmune Hepatitis. ( 28566919 )
2017
21
Prediction of oesophageal varices in patients with primary biliary cirrhosis by non-invasive markers. ( 28261290 )
2017
22
Concurrent Occurrence of Primary Biliary Cirrhosis and Rheumatoid Arthritis. ( 29057174 )
2017
23
Fungal infection involvement in primary biliary cirrhosis: A review of 2 cases. ( 28352320 )
2017
24
Autoimmune Hepatitis - Primary Biliary Cirrhosis Overlap Syndrome. ( 28892963 )
2017
25
Spontaneous Splenic Infarcts in a Cirrhotic Patient with Primary Biliary Cirrhosis. ( 28203139 )
2017
26
An Atypical Syndrome in an Elderly Patient With Systemic Lupus Erythematosus, Sjögren Syndrome, and Primary Biliary Cirrhosis. ( 30375531 )
2017
27
A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis. ( 28839853 )
2016
28
A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. ( 26842849 )
2016
29
Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis. ( 27672278 )
2016
30
Chronic spontaneous urticaria associated with primary biliary cirrhosis: a case report and literature review. ( 27879079 )
2016
31
Decreased expression of TIPE2 contributes to the hyperreactivity of monocyte to Toll-like receptor ligands in primary biliary cirrhosis. ( 26644386 )
2016
32
Changing Nomenclature for PBC from "Primary Biliary Cirrhosis" to "Primary Biliary Cholangitis". ( 27101399 )
2016
33
Low Incidence of Primary Biliary Cirrhosis (PBC) in First Degree Relatives of PBC Probands after 8 Years of Follow Up. ( 27062298 )
2016
34
Identification of microRNA profiles associated with refractory primary biliary cirrhosis. ( 27511723 )
2016
35
A Patient With Primary Biliary Cirrhosis Accompanied by Wilson's Disease. ( 27148382 )
2016
36
Clinical Course and Genetic Susceptibility of Primary Biliary Cirrhosis: Analysis of a Prospective Cohort. ( 28070198 )
2016
37
Obeticholic acid for the treatment of primary biliary cirrhosis. ( 27589928 )
2016
38
Quantitative fibrosis parameters highly predict esophageal-gastro varices in primary biliary cirrhosis. ( 27049254 )
2016
39
Liver fibrosis progression predicts survival in patients with primary biliary cirrhosis. ( 27189879 )
2016
40
Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. ( 27246196 )
2016
41
A case of primary biliary cirrhosis. ( 27728258 )
2016
42
Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis. ( 27916760 )
2016
43
Pulmonary Manifestations among Patients with Primary Biliary Cirrhosis. ( 27777894 )
2016
44
Insight into the natural history of primary biliary cirrhosis: A systemic review of data from placebo-controlled clinical trials. ( 27458850 )
2016
45
Serum proteomic signatures as biomarkers of primary biliary cirrhosis diagnosis and prognosis. ( 27707675 )
2016
46
A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica. ( 27843932 )
2016
47
Editorial: improved understanding of the epidemiology of primary biliary cirrhosis in South Korea. ( 26843341 )
2016
48
Changing Nomenclature for PBC from "Primary Biliary Cirrhosis" to "Primary Biliary Cholangitis". ( 27230619 )
2016
49
Exercise therapy in primary biliary cirrhosis: the importance of moving while sitting on a surgical waiting list-a case study. ( 27429732 )
2016
50
[Increased expression of IL-9 in peripheral blood and liver tissues of patients with primary biliary cirrhosis]. ( 27916102 )
2016

Variations for Primary Biliary Cirrhosis

Expression for Primary Biliary Cirrhosis

Search GEO for disease gene expression data for Primary Biliary Cirrhosis.

Pathways for Primary Biliary Cirrhosis

Pathways related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.8 MIR122 MIR133B MIR150 MIR20A MIR326 MIR423
2 10.54 MIR133B MIR150

GO Terms for Primary Biliary Cirrhosis

Cellular components related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 MIR122 MIR150 MIR197 MIR20A MIR212 MIR328
2 micro-ribonucleoprotein complex GO:0035068 9.5 MIR122 MIR133B MIR150 MIR197 MIR20A MIR212

Biological processes related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.53 MIR122 MIR133B MIR150 MIR197 MIR20A MIR212
2 miRNA mediated inhibition of translation GO:0035278 9.46 MIR133B MIR20A MIR212 MIR483
3 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.43 MIR361 MIR483 MIR494
4 negative regulation of blood vessel endothelial cell migration GO:0043537 9.37 MIR133B MIR212
5 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.32 MIR20A MIR451A
6 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.26 MIR20A MIR361 MIR483 MIR494

Molecular functions related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.36 MIR133B MIR150 MIR20A MIR212 MIR328 MIR361

Sources for Primary Biliary Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....