MCID: PRM006
MIFTS: 53

Primary Biliary Cirrhosis

Categories: Gastrointestinal diseases, Immune diseases, Endocrine diseases, Liver diseases

Aliases & Classifications for Primary Biliary Cirrhosis

MalaCards integrated aliases for Primary Biliary Cirrhosis:

Name: Primary Biliary Cirrhosis 38 12 76 37 15 73
Chronic Nonsuppurative Destructive Cholangitis 12
Biliary Cirrhosis Primary 55
Liver Cirrhosis, Biliary 44
Biliary Liver Cirrhosis 12
Cholestatic Cirrhosis 12
Biliary Cirrhosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12236
ICD10 33 K74.3 K74.5
ICD9CM 35 571.6
MeSH 44 D008105
KEGG 37 H01467

Summaries for Primary Biliary Cirrhosis

Disease Ontology : 12 A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.

MalaCards based summary : Primary Biliary Cirrhosis, also known as chronic nonsuppurative destructive cholangitis, is related to nonalcoholic fatty liver disease and systemic lupus erythematosus. An important gene associated with Primary Biliary Cirrhosis is DLAT (Dihydrolipoamide S-Acetyltransferase), and among its related pathways/superpathways are MicroRNAs in cancer and Cell Differentiation - Index. The drugs Ursodeoxycholic acid and chenodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and t cells.

Wikipedia : 76 Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune... more...

Related Diseases for Primary Biliary Cirrhosis

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 1 Biliary Cirrhosis, Primary, 2
Biliary Cirrhosis, Primary, 3 Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Primary Biliary Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 nonalcoholic fatty liver disease 29.8 MIR122 MIR30D MIR451A
2 systemic lupus erythematosus 28.8 MIR150 MIR197 MIR30D MIR346 MIR423 MIR494
3 primary biliary cholangitis 12.5
4 reynolds syndrome 12.3
5 biliary cirrhosis, primary, 1 12.2
6 biliary cirrhosis, primary, 2 11.2
7 biliary cirrhosis, primary, 3 11.2
8 biliary cirrhosis, primary, 4 11.2
9 biliary cirrhosis, primary, 5 11.2
10 hepatitis 10.8
11 autoimmune hepatitis 10.7
12 cholangitis 10.6
13 sclerosing cholangitis 10.5
14 cholangitis, primary sclerosing 10.5
15 pituitary adenoma 10.5 MIR197 MIR212
16 hepatocellular carcinoma 10.4
17 liver disease 10.4
18 scleroderma, familial progressive 10.3
19 arthritis 10.3
20 autoimmune disease 10.2
21 rheumatoid arthritis 10.2
22 autoimmune disease 1 10.2
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
24 renal tubular acidosis 10.2
25 hepatitis c 10.2
26 osteoporosis 10.2
27 hemolytic anemia 10.2
28 membranous nephropathy 10.2
29 glomerulonephritis 10.2
30 hepatitis b 10.2
31 bone disease 10.2
32 thyroiditis 10.2
33 anemia, autoimmune hemolytic 10.2
34 lupus erythematosus 10.2
35 nodular regenerative hyperplasia 10.2
36 oral squamous cell carcinoma 10.1 MIR122 MIR133B MIR197 MIR30D
37 pernicious anemia 10.1
38 lymphoma 10.1
39 osteomalacia 10.1
40 cholestasis 10.1
41 kidney cancer 10.1 MIR122 MIR150
42 portal hypertension 10.1
43 esophagitis 10.1
44 connective tissue disease 10.1
45 celiac disease 1 10.0
46 helicobacter pylori infection 10.0
47 crest syndrome 10.0
48 fanconi syndrome 10.0
49 dermatitis 10.0
50 myelitis 10.0

Comorbidity relations with Primary Biliary Cirrhosis via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Cholangitis Deficiency Anemia
Hepatic Encephalopathy Hypothyroidism
Portal Hypertension

Graphical network of the top 20 diseases related to Primary Biliary Cirrhosis:



Diseases related to Primary Biliary Cirrhosis

Symptoms & Phenotypes for Primary Biliary Cirrhosis

Drugs & Therapeutics for Primary Biliary Cirrhosis

Drugs for Primary Biliary Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 132)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128-13-2 31401
2
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
3
Abatacept Approved Phase 4 332348-12-6 10237
4
Methionine Approved, Nutraceutical Phase 4,Phase 2 63-68-3 6137
5 Liver Extracts Phase 4,Phase 3,Phase 2,Not Applicable
6 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
8 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Cathartics Phase 4,Phase 3,Phase 2,Early Phase 1
10 Laxatives Phase 4,Phase 3,Phase 2,Early Phase 1
11 Immunosuppressive Agents Phase 4,Phase 3,Not Applicable
12
Fenofibrate Approved Phase 3,Phase 2,Phase 1 49562-28-9 3339
13
Bezafibrate Approved, Investigational Phase 3 41859-67-0 39042
14
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
15
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
16
Tauroursodeoxycholic acid Approved, Investigational Phase 3 14605-22-2 12443252
17
Copper Approved, Investigational Phase 3 7440-50-8 27099
18
Molybdenum Approved Phase 3 7439-98-7 185498
19
Colchicine Approved Phase 3 64-86-8 6167 2833
20
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
21
Budesonide Approved Phase 3,Phase 1,Not Applicable 51333-22-3 63006 5281004
22
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
23
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
25
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
26 Antimetabolites Phase 3,Phase 2,Phase 1
27 Hypolipidemic Agents Phase 3,Phase 2,Phase 1
28 Lipid Regulating Agents Phase 3,Phase 2,Phase 1
29 Anti-HIV Agents Phase 2, Phase 3,Not Applicable
30 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
31 Anti-Retroviral Agents Phase 2, Phase 3,Not Applicable
32 Antiviral Agents Phase 2, Phase 3,Phase 3,Not Applicable
33 Lamivudine, zidovudine drug combination Phase 2, Phase 3
34 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable
35 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Not Applicable
36 Taurochenodeoxycholic Acid Phase 3
37 Angiogenesis Inhibitors Phase 3
38 Angiogenesis Modulating Agents Phase 3
39 Chelating Agents Phase 3
40 Micronutrients Phase 3,Not Applicable
41 Tetrathiomolybdate Phase 3
42 Trace Elements Phase 3,Not Applicable
43 Anticholesteremic Agents Phase 3,Phase 1
44 Atorvastatin Calcium Phase 3 134523-03-8
45 Calcium, Dietary Phase 3
46 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
47 Antimetabolites, Antineoplastic Phase 3
48 Antimitotic Agents Phase 3
49 Dermatologic Agents Phase 3,Phase 2
50 Folic Acid Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 103)
# Name Status NCT ID Phase Drugs
1 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
2 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
3 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic
4 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
5 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
6 Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Unknown status NCT02823353 Phase 3 Fenofibrate;UDCA
7 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Unknown status NCT02823366 Phase 3 Fenofibrate;UDCA
8 The Effect of Bezafibrate on Cholestatic Itch Unknown status NCT02701166 Phase 3 Bezafibrate;Placebo
9 Study of Combivir for Patients With Primary Biliary Cirrhosis Completed NCT00490620 Phase 2, Phase 3 Combination antiviral therapy;Placebo
10 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3 Tauroursodeoxycholic Acid Capsules;Ursodeoxycholic Acid Capsules
11 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3 Tetrathiomolybdate
12 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
13 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis Completed NCT00004748 Phase 3 colchicine;methotrexate;ursodiol
14 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3 Bezafibrate;placebo
15 Ursodiol-Methotrexate for Primary Biliary Cirrhosis Completed NCT00006168 Phase 3 Methotrexate
16 Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis Completed NCT00004784 Phase 3 methotrexate;ursodiol
17 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid
18 Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders Recruiting NCT02937012 Phase 3 Bezafibrate;Ursodeoxycholic Acid;Placebo (for Bezafibrate)
19 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) Recruiting NCT03301506 Phase 2, Phase 3 Seladelpar 2 mg Capsule;Seladelpar 5 mg Capsule;Seladelpar 10 mg Capsule
20 Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Recruiting NCT02916290 Phase 3 Fuzhenghuayu;UDCA
21 Fuzhenghuayu for Patients With PBC Who Had An Inadequate Response to Ursodeoxycholic Acid Recruiting NCT02916641 Phase 3 Fuzhenghuayu;UDCA
22 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Recruiting NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
23 Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis Active, not recruiting NCT01473524 Phase 3 Obeticholic Acid (OCA);Placebo
24 Metformin in Intrahepatic Cholestasis of Pregnancy Not yet recruiting NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
25 Ursodeoxycholic Acid Plus Budesonide Versus Ursodeoxycholic Acid Alone in Primary Biliary Cirrhosis (PBC) Terminated NCT00746486 Phase 3 budesonide;budesonide placebo
26 Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis Unknown status NCT01662973 Phase 1, Phase 2
27 Study of Rituximab in Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease Unknown status NCT00472225 Phase 2 Rituximab
28 Moexipril for Primary Biliary Cirrhosis Completed NCT00588302 Phase 2 Moexipril
29 Initial Study of Rituximab to Treat Primary Biliary Cirrhosis Completed NCT00364819 Phase 1, Phase 2 rituximab
30 Use of Fenofibrate for Primary Biliary Cirrhosis Completed NCT00575042 Phase 2 Fenofibrate IDD-P (Insoluble Drug Delivery-Micro Particle)
31 A Study of Efficacy and Safety of Ustekinumab in Patients With Primary Biliary Cirrhosis (PBC) Who Had an Inadequate Response to Ursodeoxycholic Acid Completed NCT01389973 Phase 2 ustekinumab 90 mg;ustekinumab 45 mg;ustekinumab 180 mg;Placebo
32 Phase 2b Study of NGM282 Extended Treatment in Patients With Primary Biliary Cirrhosis Completed NCT02135536 Phase 2
33 Phase 2 Study of NGM282 in Patients With Primary Biliary Cirrhosis Completed NCT02026401 Phase 2
34 Pentoxifylline for Primary Biliary Cirrhosis Completed NCT01249092 Phase 2 Pentoxifylline
35 B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis Completed NCT02376335 Phase 2
36 Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis Completed NCT01904058 Phase 2 LUM001;Placebo;Ursodeoxycholic Acid
37 Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Subjects With Primary Biliary Cirrhosis Completed NCT01865812 Phase 2 obeticholic acid (OCA)
38 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus Completed NCT01899703 Phase 2 GSK2330672;Placebo;Ursodeoxycholic acid
39 Study of INT 747 in Combination With URSO in Patients With Primay Biliary Cirrhosis (PBC) Completed NCT00550862 Phase 2 INT-747;Ursodeoxycholic Acid (URSO);Placebo
40 Study of INT-747 as Monotherapy in Patients With PBC Completed NCT00570765 Phase 2 Placebo;INT-747;INT-747
41 Treatment of Cholestatic Pruritus With Sertraline Completed NCT00058903 Phase 2 sertraline
42 A Study to Evaluate Safety, Tolerability and Efficacy of Saroglitazar Magnesium in Patients With Primary Biliary Cholangitis (EPICS) Recruiting NCT03112681 Phase 2 Saroglitazar magnesium 2 mg;Saroglitazar magnesium 4 mg;Placebo Oral Tablet
43 Study to Assess Safety and Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid. Recruiting NCT03226067 Phase 2 GKT137831;Placebo oral capsule
44 Study of E6011 in Japanese Subjects With Primary Biliary Cholangitis Inadequately Responding to Ursodeoxycholic Acid Recruiting NCT03092765 Phase 2 E6011;Placebo
45 Safety, Tolerability, and Efficacy of Etrasimod (APD334) in Patients With Primary Biliary Cholangitis Recruiting NCT03155932 Phase 2 APD334
46 A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis Recruiting NCT03394924 Phase 2 EDP-305 Dose 1;EDP-305 Dose 2;Placebo
47 A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in PBC Patients Recruiting NCT02516605 Phase 2 Part 1: LJN452;Part 1: Placebo;Part 2: LJN452 Dose level 1;Part 2: Placebo;Part 2: LJN452 Dose level 2
48 Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) and Inadequate Response to Ursodeoxycholic Acid Recruiting NCT03124108 Phase 2 Elafibranor 80 mg;Elafibranor 120 mg;Placebo
49 Non-comparative Study of BCD-085 in Combination With UDCA in Patients With Primary Biliary Cholangitis Recruiting NCT03476993 Phase 2
50 Pilot Study of FFP104 Dose Escalation in PBC Subjects Recruiting NCT02193360 Phase 1, Phase 2 FFP104

Search NIH Clinical Center for Primary Biliary Cirrhosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Primary Biliary Cirrhosis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: liver cirrhosis, biliary

Genetic Tests for Primary Biliary Cirrhosis

Anatomical Context for Primary Biliary Cirrhosis

MalaCards organs/tissues related to Primary Biliary Cirrhosis:

41
Liver, T Cells, Bone, B Cells, Lung, Testes, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Primary Biliary Cirrhosis:
# Tissue Anatomical CompartmentCell Relevance
1 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Primary Biliary Cirrhosis

Articles related to Primary Biliary Cirrhosis:

(show top 50) (show all 1451)
# Title Authors Year
1
IgG4-related retroperitoneal fibrosis overlapping with primary biliary cirrhosis and primary SjAPgren's syndrome: A case report. ( 29953016 )
2018
2
Lower Plasma Levels of IL-35 in Patients with Primary Biliary Cirrhosis. ( 29445068 )
2018
3
Palmoplantar keratoderma as a presenting sign of primary biliary cirrhosis. ( 29270458 )
2018
4
Increased risk of osteoporosis in patients with primary biliary cirrhosis. ( 29543880 )
2018
5
Primary myelofibrosis but not autoimmune myelofibrosis accompanied by SjAPgren's syndrome and primary biliary cirrhosis in a patient with trisomy 8 mosaic: a case report and literature review. ( 29745886 )
2018
6
Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and SjAPgren syndrome: A case report. ( 29465536 )
2018
7
Primary Biliary Cholangitis (Primary Biliary Cirrhosis) ( 29083627 )
2017
8
Interstitial granulomatous dermatitis associated with primary biliary cirrhosis. ( 28225148 )
2017
9
Clinical relevance of combined anti-mitochondrial M2 detection assays for primary biliary cirrhosis. ( 27864100 )
2017
10
Successful infliximab therapy in a patient with comorbid spondyloarthritis, primary biliary cirrhosis and generalized morphea. ( 28229620 )
2017
11
Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis. ( 29113177 )
2017
12
Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury. ( 28823616 )
2017
13
A Case of Primary Biliary Cirrhosis Mimicking Acute Hepatitis B in the Clinic, Republic of Korea. ( 28197333 )
2017
14
Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. ( 28570655 )
2017
15
[Single nucleotide polymorphism of STAT4 rs7574865 is associated with the susceptibility of primary biliary cirrhosis in Han population of partial regions of Jiangsu province]. ( 28395724 )
2017
16
Xanthoma Striatum Palmare in a Patient of Primary Biliary Cirrhosis with Autoimmune Hepatitis. ( 28566919 )
2017
17
Prediction of oesophageal varices in patients with primary biliary cirrhosis by non-invasive markers. ( 28261290 )
2017
18
Concurrent Occurrence of Primary Biliary Cirrhosis and Rheumatoid Arthritis. ( 29057174 )
2017
19
Fungal infection involvement in primary biliary cirrhosis: A review of 2 cases. ( 28352320 )
2017
20
Autoimmune Hepatitis - Primary Biliary Cirrhosis Overlap Syndrome. ( 28892963 )
2017
21
Spontaneous Splenic Infarcts in a Cirrhotic Patient with Primary Biliary Cirrhosis. ( 28203139 )
2017
22
A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis. ( 28839853 )
2016
23
A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. ( 26842849 )
2016
24
Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis. ( 27672278 )
2016
25
Chronic spontaneous urticaria associated with primary biliary cirrhosis: a case report and literature review. ( 27879079 )
2016
26
Decreased expression of TIPE2 contributes to the hyperreactivity of monocyte to Toll-like receptor ligands in primary biliary cirrhosis. ( 26644386 )
2016
27
Low Incidence of Primary Biliary Cirrhosis (PBC) in First Degree Relatives of PBC Probands after 8 Years of Follow Up. ( 27062298 )
2016
28
Identification of microRNA profiles associated with refractory primary biliary cirrhosis. ( 27511723 )
2016
29
A Patient With Primary Biliary Cirrhosis Accompanied by Wilson's Disease. ( 27148382 )
2016
30
Clinical Course and Genetic Susceptibility of Primary Biliary Cirrhosis: Analysis of a Prospective Cohort. ( 28070198 )
2016
31
Obeticholic acid for the treatment of primary biliary cirrhosis. ( 27589928 )
2016
32
Quantitative fibrosis parameters highly predict esophageal-gastro varices in primary biliary cirrhosis. ( 27049254 )
2016
33
Liver fibrosis progression predicts survival in patients with primary biliary cirrhosis. ( 27189879 )
2016
34
Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. ( 27246196 )
2016
35
A case of primary biliary cirrhosis. ( 27728258 )
2016
36
Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis. ( 27916760 )
2016
37
Pulmonary Manifestations among Patients with Primary Biliary Cirrhosis. ( 27777894 )
2016
38
Insight into the natural history of primary biliary cirrhosis: A systemic review of data from placebo-controlled clinical trials. ( 27458850 )
2016
39
Serum proteomic signatures as biomarkers of primary biliary cirrhosis diagnosis and prognosis. ( 27707675 )
2016
40
A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica. ( 27843932 )
2016
41
Editorial: improved understanding of the epidemiology of primary biliary cirrhosis in South Korea. ( 26843341 )
2016
42
Exercise therapy in primary biliary cirrhosis: the importance of moving while sitting on a surgical waiting list-a case study. ( 27429732 )
2016
43
[Increased expression of IL-9 in peripheral blood and liver tissues of patients with primary biliary cirrhosis]. ( 27916102 )
2016
44
Diagnostic accuracy of two tests for determination of anti-m2 in the diagnosis of primary biliary cirrhosis: Is it possible to predict the course of the disease? ( 27475095 )
2016
45
Association of IL12A Expression Quantitative Trait Loci (eQTL) With Primary Biliary Cirrhosis in a Chinese Han Population. ( 27175695 )
2016
46
Primary Biliary Cirrhosis and the Microbiome. ( 27997975 )
2016
47
Bullous pemphigoid and primary biliary cirrhosis, an infrequent association: A case report. ( 26949192 )
2016
48
Liver damage in primary biliary cirrhosis and accompanied by primary SjAPgren's syndrome: a retrospective pilot study. ( 27536204 )
2016
49
Red blood cell distribution width and mean platelet volume are potential prognostic indices for patients with primary biliary cirrhosis. ( 27754960 )
2016
50
A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han. ( 27047549 )
2016

Variations for Primary Biliary Cirrhosis

Expression for Primary Biliary Cirrhosis

Search GEO for disease gene expression data for Primary Biliary Cirrhosis.

Pathways for Primary Biliary Cirrhosis

Pathways related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 MIR122 MIR133B MIR150 MIR30D MIR326 MIR423
2 10.54 MIR133B MIR150

GO Terms for Primary Biliary Cirrhosis

Cellular components related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 MIR122 MIR150 MIR197 MIR212 MIR30D MIR328

Biological processes related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.28 MIR133B MIR150 MIR212 MIR328 MIR361 MIR423
2 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.26 MIR361 MIR494
3 negative regulation of blood vessel endothelial cell migration GO:0043537 9.16 MIR133B MIR212
4 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 8.96 MIR361 MIR494

Molecular functions related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.28 MIR133B MIR150 MIR212 MIR328 MIR361 MIR423

Sources for Primary Biliary Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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