MCID: PRM243
MIFTS: 22

Primary Bone Cancer

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Primary Bone Cancer

MalaCards integrated aliases for Primary Bone Cancer:

Name: Primary Bone Cancer 20
Primary Malignant Neoplasm of Bone 20 70
Rare Bone Tumor 20 58
Primary Bone Osteosarcoma 70

Classifications:

Orphanet: 58  
Rare bone diseases


External Ids:

UMLS via Orphanet 71 C0005967
Orphanet 58 ORPHA68411
UMLS 70 C1313974 C1704291

Summaries for Primary Bone Cancer

MalaCards based summary : Primary Bone Cancer, also known as primary malignant neoplasm of bone, is related to bone cancer and osteogenic sarcoma. An important gene associated with Primary Bone Cancer is MAPK7 (Mitogen-Activated Protein Kinase 7). Affiliated tissues include bone, prostate and bone marrow.

Related Diseases for Primary Bone Cancer

Diseases in the Bone Cancer family:

Primary Bone Cancer

Diseases related to Primary Bone Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 bone cancer 29.8 MRC2 MAPK7
2 osteogenic sarcoma 11.1
3 chondrosarcoma 10.1
4 ewing sarcoma 10.1
5 rare tumor 10.0
6 angiosarcoma 9.9
7 fibroma 9.9
8 hemangioma 9.9
9 chordoma 9.8
10 ameloblastoma 9.8
11 bone sarcoma 9.8
12 sarcoma 9.8
13 spindle cell sarcoma 9.8
14 48,xyyy 9.8
15 osteoblastoma 9.8
16 scoliosis 9.8
17 bone resorption disease 9.8
18 desmoid tumor 9.8
19 ossifying fibroma 9.8
20 chondroblastoma 9.8
21 fibrous histiocytoma 9.8
22 histiocytoid hemangioma 9.8
23 cavernous hemangioma 9.8
24 fibromatosis 9.8
25 angiomatosis 9.8

Graphical network of the top 20 diseases related to Primary Bone Cancer:



Diseases related to Primary Bone Cancer

Symptoms & Phenotypes for Primary Bone Cancer

Drugs & Therapeutics for Primary Bone Cancer

Search Clinical Trials , NIH Clinical Center for Primary Bone Cancer

Genetic Tests for Primary Bone Cancer

Anatomical Context for Primary Bone Cancer

MalaCards organs/tissues related to Primary Bone Cancer:

40
Bone, Prostate, Bone Marrow, Spinal Cord, Nk Cells

Publications for Primary Bone Cancer

Articles related to Primary Bone Cancer:

(show top 50) (show all 268)
# Title Authors PMID Year
1
The role of Notch ligand Jagged1 in osteosarcoma proliferation, metastasis, and recurrence. 61
33781318 2021
2
Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival. 61
33536423 2021
3
Rib Osteoblastoma as a Cause of Neurogenic Thoracic Outlet Syndrome: A Case Report. 61
33556044 2021
4
18F-labeled bisphosphonate as an alternative candidate to the gold standard [18F]sodium fluoride ([18F]NaF) for PET bone imaging. 61
33593263 2021
5
Metastasizing chondroblastoma: a rare bone tumor no longer supported by the WHO classification. 61
32594198 2021
6
Fibrocartilaginous mesenchymoma with an unusual location in the rib. 61
33260287 2021
7
Novel Nomograms as Aids for Predicting Recurrence and Survival in Chordoma Patients: A Retrospective Multicenter Study in mainland China. 61
32991511 2021
8
Surgical Advances in Osteosarcoma. 61
33494243 2021
9
Thiostrepton and miR-216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1. 61
33193851 2020
10
Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy. 61
32060984 2020
11
A 3D-printed biomaterials-based platform to advance established therapy avenues against primary bone cancers. 61
33039595 2020
12
Unique presentation of palatal metastasis from high-grade spindle cell sarcoma of the bone. 61
33139360 2020
13
Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis. 61
33154487 2020
14
The local and circulating SOX9 as a potential biomarker for the diagnosis of primary bone cancer. 61
32551218 2020
15
Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer. 61
32655131 2020
16
Molecular Biology of Osteosarcoma. 61
32751922 2020
17
Autophagy regulation by microRNAs: Novel insights into osteosarcoma therapy. 61
32233112 2020
18
The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo. 61
32390003 2020
19
Bone Tumors: Primary Bone Cancers. 61
32573183 2020
20
The Proteasome Inhibitor Ixazomib Inhibits the Formation and Growth of Pulmonary and Abdominal Osteosarcoma Metastases in Mice. 61
32403415 2020
21
Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling. 61
32072182 2020
22
The first total vertebral involvement of benign fibrous histiocytoma: A case report and literature review. 61
31908914 2020
23
Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis. 61
32033398 2020
24
Long Non-Coding RNA KCNQ1OT1 Promotes Multidrug Resistance in Chordoma by Functioning as a Molecular Sponge of miR-27b-3p and Subsequently Increasing ATF2 Expression. 61
32922083 2020
25
Antimetastatic Potential of Rhodomyrtone on Human Chondrosarcoma SW1353 Cells. 61
32802134 2020
26
MiR-196a promoted cell migration, invasion and the epithelial-mesenchymal transition by targeting HOXA5 in osteosarcoma. 61
32675397 2020
27
Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/β-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway. 61
33042426 2020
28
Cold Plasma-Treated Ringer's Saline: A Weapon to Target Osteosarcoma. 61
31963398 2020
29
Juvenile Psammomatoid Ossifying Fibroma of the Orbital Roof: A Rare Cause of Proptosis among Children. 61
32756056 2020
30
Epidemiological Study of Adamantinoma from US Surveillance, Epidemiology, and End Results Program: III Retrospective Analysis. 61
32612653 2020
31
Tissue-engineered 3D models for elucidating primary and metastatic bone cancer progression. 61
31419564 2019
32
Desmoplastic fibroma of the mandible: a rare gnathic bone tumor with a review of the literature. 61
31641651 2019
33
Primary Bone Tumors: Challenges and Opportunities for CAR-T Therapies. 61
31441962 2019
34
The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma. 61
29117898 2019
35
Qualitative study exploring patients experiences of being diagnosed and living with primary bone cancer in the UK. 61
31551374 2019
36
MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2. 61
31193934 2019
37
Nomogram for Individualized Prediction and Prognostic Factors for Survival in Patients with Primary Spinal Chordoma: A Population-Based Longitudinal Cohort Study. 61
31054340 2019
38
In vitro and in vivo studies of antiosteosarcoma activities of formononetin. 61
30790283 2019
39
High-resolution large-area imaging of nanoscale structure and mineralization of a sclerosing osteosarcoma in human bone. 61
31004766 2019
40
12b80 - Hydroxybisphosphonate Linked Doxorubicin: Bone Targeted Strategy for Treatment of Osteosarcoma. 61
31045351 2019
41
Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice. 61
31151929 2019
42
Three-year follow-up of a phase II study of radium-223 dichloride in Japanese patients with symptomatic castration-resistant prostate cancer and bone metastases. 61
30875000 2019
43
Unlocking bone for proteomic analysis and FISH. 61
30659273 2019
44
Fluoridation and county-level secondary bone cancer among cancer patients 18 years or older in New York State. 61
30109528 2019
45
SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission. 61
30579931 2019
46
Incidence and mortality of primary bone cancers in China, 2014. 61
30996571 2019
47
Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells. 61
30504231 2019
48
Small-molecule targeting of brachyury transcription factor addiction in chordoma. 61
30664779 2019
49
Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma. 61
30542727 2019
50
Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma. 61
30774369 2019

Variations for Primary Bone Cancer

Expression for Primary Bone Cancer

Search GEO for disease gene expression data for Primary Bone Cancer.

Pathways for Primary Bone Cancer

GO Terms for Primary Bone Cancer

Sources for Primary Bone Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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