MCID: PRM001
MIFTS: 48

Primary Cutaneous Amyloidosis

Categories: Rare diseases, Skin diseases, Metabolic diseases, Genetic diseases

Aliases & Classifications for Primary Cutaneous Amyloidosis

MalaCards integrated aliases for Primary Cutaneous Amyloidosis:

Name: Primary Cutaneous Amyloidosis 12 76 53 25 15
Primary Localized Cutaneous Amyloidosis 53 25 37
Familial Primary Localized Cutaneous Amyloidosis 12 59
Amyloidosis, Primary Cutaneous 55 73
Amyloidosis Ix 53 25
Plca 53 25
Amyloidosis Familial Cutaneous Lichen 53
Lichen Amyloidosis Familial 53
Familial Lichen Amyloidosis 73
Amyloidosis 9 53
Fplca 59
Pca 12

Characteristics:

Orphanet epidemiological data:

59
familial primary localized cutaneous amyloidosis
Inheritance: Autosomal dominant; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:0050639
Orphanet 59 ORPHA353220
ICD10 via Orphanet 34 E85.4+ L99.0*
KEGG 37 H01217

Summaries for Primary Cutaneous Amyloidosis

NIH Rare Diseases : 53 Primary cutaneous amyloidosis is a form of amyloidosis, a group of conditions in which an abnormal protein (called amyloid) builds up in various organs and tissues throughout the body. In primary cutaneous amyloidosis, specifically, this protein accumulates in the skin. There are three main forms of primary cutaneous amyloidosis:Lichen amyloidosis - multiple itchy, raised spots which are scaly and red/brown in color. This rash generally affects the shins, thighs, feet and forearms. Macular amyloidosis - mild to severely itchy, flat, dusky-brown or greyish colored spots that may come together to form patches of darkened skin. This rash generally appears on the upper back between the shoulder blades, the chest and less commonly, the arms. Nodular amyloidosis - asymptomatic firm bumps that may be pinkish-brown to red in color. This rash may occur on the trunk, limbs, face, and/or genitals. The exact underlying cause of primary cutaneous amyloidosis is poorly understood. It is sometimes associated with other conditions such as atopic dermatitis, sarcoidosis, and psoriasis. Although most cases occur sporadically in people with no family history of the condition, there are rare familial forms caused by changes (mutations) in the OSMR or IL31RA gene. Treatment is based on the signs and symptoms present in each person and may include surgery to remove amyloid deposits and/or certain medications to relieve itching.

MalaCards based summary : Primary Cutaneous Amyloidosis, also known as primary localized cutaneous amyloidosis, is related to lichen amyloidosis and posterior cortical atrophy. An important gene associated with Primary Cutaneous Amyloidosis is OSMR (Oncostatin M Receptor), and among its related pathways/superpathways are Cytokine-cytokine receptor interaction and Jak-STAT signaling pathway. The drugs Methylene blue and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and b cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Genetics Home Reference : 25 Primary localized cutaneous amyloidosis (PLCA) is a condition in which clumps of abnormal proteins called amyloids build up in the skin, specifically in the wave-like projections (dermal papillae) between the top two layers of skin (the dermis and the epidermis). The primary feature of PLCA is patches of skin with abnormal texture or color. The appearance of these patches defines three forms of the condition: lichen amyloidosis, macular amyloidosis, and nodular amyloidosis.

Disease Ontology : 12 An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis.

Wikipedia : 76 Primary cutaneous amyloidosis is a form of amyloidosis associated with oncostatin M receptor. This type... more...

Related Diseases for Primary Cutaneous Amyloidosis

Diseases in the Primary Cutaneous Amyloidosis family:

Amyloidosis, Primary Localized Cutaneous, 1 Amyloidosis, Primary Localized Cutaneous, 2
Amyloidosis, Primary Localized Cutaneous, 3

Diseases related to Primary Cutaneous Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 lichen amyloidosis 33.5 IL31 IL31RA OSMR
2 posterior cortical atrophy 11.8
3 amyloidosis, primary localized cutaneous, 3 11.4
4 amyloidosis, primary localized cutaneous, 1 11.1
5 macular amyloidosis 11.0 IL31RA OSMR
6 epidermolysis bullosa simplex, autosomal recessive 1 10.9 KRT14 KRT5
7 epidermolysis bullosa simplex, localized 10.9 KRT14 KRT5
8 neurenteric cyst 10.9 KRT18 KRT8
9 transitional papilloma 10.9 KRT17 KRT18
10 inverted transitional papilloma 10.8 KRT5 KRT7
11 clear cell basal cell carcinoma 10.8 KRT17 KRT7
12 balloon cell malignant melanoma 10.8 KRT5 KRT7
13 pachyonychia congenita 2 10.8 KRT16 KRT17
14 lichen planopilaris 10.8 KRT14 KRT5
15 malignant spiradenoma 10.8 KRT5 KRT7
16 idiopathic corneal edema 10.8 KRT19 KRT8
17 sensory organ benign neoplasm 10.8 KRT5 KRT7
18 tinea corporis 10.7 KRT16 KRT17
19 epidermolysis bullosa simplex with mottled pigmentation 10.7 KRT10 KRT14 KRT5
20 breast squamous cell carcinoma 10.7 KRT10 KRT14 KRT5
21 endolymphatic sac tumor 10.7 KRT7 KRT8
22 epidermolysis bullosa simplex, dowling-meara type 10.7 KRT10 KRT14 KRT5
23 steatocystoma multiplex 10.7 KRT10 KRT16 KRT17
24 intrahepatic bile duct adenoma 10.7 KRT19 KRT7
25 basal cell carcinoma, infundibulocystic 10.7 KRT10 KRT14 KRT17
26 malignant syringoma 10.7 KRT17 KRT7
27 predominantly cortical thymoma 10.7 KRT14 KRT19
28 anal gland adenocarcinoma 10.7 KRT19 KRT7
29 bile duct mucoepidermoid carcinoma 10.7 KRT5 KRT7
30 middle ear adenoma 10.7 KRT5 KRT7
31 malignant biphasic mesothelioma 10.7 KRT10 KRT5 KRT7
32 epidermolysis bullosa simplex 10.7 KRT10 KRT14 KRT5
33 pachyonychia congenita 1 10.7 KRT10 KRT16 KRT17
34 keratoacanthoma 10.7 KRT10 KRT16 KRT17
35 pre-malignant neoplasm 10.7 KRT14 KRT17 KRT5
36 benign breast adenomyoepithelioma 10.7 KRT14 KRT5 KRT7
37 anus adenocarcinoma 10.6 KRT19 KRT7
38 in situ carcinoma 10.6 KRT14 KRT17 KRT5
39 epithelioid trophoblastic tumor 10.6 KRT18 KRT7
40 breast adenomyoepithelioma 10.6 KRT14 KRT5 KRT7
41 breast myoepithelial neoplasm 10.6 KRT14 KRT5 KRT7
42 hidrocystoma 10.6 KRT7 KRT8
43 nodular hidradenoma 10.6 KRT10 KRT7
44 renal pelvis adenocarcinoma 10.6 KRT19 KRT7
45 papillary adenoma 10.6 KRT5 KRT7
46 atypical choroid plexus papilloma 10.6 KRT5 KRT7 KRT8
47 prostate squamous cell carcinoma 10.6 KRT5 KRT7 KRT8
48 nasal cavity squamous cell carcinoma 10.6 KRT5 KRT7 KRT8
49 amyloidosis 10.6
50 breast secretory carcinoma 10.6 KRT5 KRT7 KRT8

Graphical network of the top 20 diseases related to Primary Cutaneous Amyloidosis:



Diseases related to Primary Cutaneous Amyloidosis

Symptoms & Phenotypes for Primary Cutaneous Amyloidosis

GenomeRNAi Phenotypes related to Primary Cutaneous Amyloidosis according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.91 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.91 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.91 KRT18 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.91 KRT5 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.91 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.91 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.91 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.91 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.91 KRT18 KRT5 KRT7 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.91 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.91 KRT18
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.91 KRT5 KRT7
13 Reduced mammosphere formation GR00396-S 9.17 KRT7 MYLK CALM1 CALM2 CALM3 CCL2

MGI Mouse Phenotypes related to Primary Cutaneous Amyloidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 KRT14 KRT16 KRT17 KRT19 KRT5 KRT8

Drugs & Therapeutics for Primary Cutaneous Amyloidosis

Drugs for Primary Cutaneous Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Not Applicable 61-73-4
2 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians Recruiting NCT03068156 Not Applicable
2 Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians Not yet recruiting NCT03068208 Not Applicable

Search NIH Clinical Center for Primary Cutaneous Amyloidosis

Genetic Tests for Primary Cutaneous Amyloidosis

Anatomical Context for Primary Cutaneous Amyloidosis

MalaCards organs/tissues related to Primary Cutaneous Amyloidosis:

41
Skin, B Cells

Publications for Primary Cutaneous Amyloidosis

Articles related to Primary Cutaneous Amyloidosis:

(show top 50) (show all 63)
# Title Authors Year
1
Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and SjAPgren syndrome: A case report. ( 29465536 )
2018
2
Primary Cutaneous Amyloidosis: A Clinical, Histopathological and Immunofluorescence Study. ( 28969251 )
2017
3
An unusual presentation of primary cutaneous amyloidosis. ( 29469741 )
2017
4
Reflectance confocal microscopy for the characterization of primary cutaneous amyloidosis: a pilot study. ( 28083882 )
2017
5
Comparative proteomics analysis of primary cutaneous amyloidosis. ( 28912854 )
2017
6
Primary cutaneous amyloidosis of the auricular concha - case report. ( 29186270 )
2017
7
Health-related quality of life in patients with primary cutaneous amyloidosis. ( 25799390 )
2015
8
Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: A randomized clinical trial. ( 25946210 )
2015
9
Amyloidosis cutis dyschromia: a rare form of primary cutaneous amyloidosis. ( 24746296 )
2014
10
Nodular localized primary cutaneous amyloidosis: a bullous variant. ( 24635076 )
2014
11
Unilateral primary cutaneous amyloidosis of the eyelid masquerading as a chalazion. ( 25284111 )
2014
12
Reactive eccrine syringofibroadenomatosis secondary to primary cutaneous amyloidosis: a novel association. ( 24325801 )
2013
13
MCP-1 as an effector of IL-31 signaling in familial primary cutaneous amyloidosis. ( 23303452 )
2013
14
Primary cutaneous amyloidosis of the glans penis. Two case reports and a review of the literature. ( 24125073 )
2013
15
Thalidomide improves clinical symptoms of primary cutaneous amyloidosis: report of familiar and sporadic cases. ( 23742287 )
2013
16
Poikiloderma-like primary cutaneous amyloidosis confined to the calves in a Chinese man. ( 22776500 )
2012
17
Primary cutaneous amyloidosis of the external ear: a clinicopathological and immunohistochemical study of 17 cases. ( 22077601 )
2012
18
Characteristic dermoscopic features of primary cutaneous amyloidosis: a study of 35 cases. ( 22632408 )
2012
19
Primary cutaneous amyloidosis: a clinico-pathological study with emphasis on polarized microscopy. ( 22771637 )
2012
20
Association of primary cutaneous amyloidosis with atopic dermatitis: a nationwide population-based study in Taiwan. ( 21070198 )
2011
21
Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis. ( 21669474 )
2011
22
Nodular localized primary cutaneous amyloidosis and primary marginal zone B-cell lymphoma on the nose: treatment with microscopically controlled surgery. ( 21413960 )
2011
23
Unusual primary cutaneous amyloidosis with an incontinentia pigmenti-like pattern. ( 21413964 )
2011
24
Dramatic improvement of primary cutaneous amyloidosis with thalidomide. ( 21382777 )
2011
25
A rare type of primary cutaneous amyloidosis: amyloidosis cutis dyschromica. ( 21091677 )
2010
26
Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. ( 19690585 )
2010
27
Identification of an oncostatin M receptor mutation associated with familial primary cutaneous amyloidosis. ( 19466957 )
2009
28
Papules and plaques on the nose. Nodular localized primary cutaneous amyloidosis. ( 17438189 )
2007
29
Primary cutaneous amyloidosis of the auricular concha: case report and review of published work. ( 16556282 )
2006
30
A comparative study of two Congo red stains for the detection of primary cutaneous amyloidosis. ( 16844537 )
2006
31
Genome-wide scan identifies a susceptibility locus for familial primary cutaneous amyloidosis on chromosome 5p13.1-q11.2. ( 17107390 )
2006
32
Suggestive linkage of familial primary cutaneous amyloidosis to a locus on chromosome 1q23. ( 15656797 )
2005
33
Primary cutaneous amyloidosis. ( 11991040 )
2002
34
Nodular localized primary cutaneous amyloidosis. ( 12174132 )
2002
35
Nodular localized primary cutaneous amyloidosis: a long-term follow-up study. ( 11453916 )
2001
36
Primary cutaneous amyloidosis involving the external ears along with the classical sites. ( 17664705 )
2001
37
Clinical and histopathological characteristics of primary cutaneous amyloidosis in 794 Chinese patients. ( 11355326 )
2001
38
Familial primary cutaneous amyloidosis in a South African family. ( 10606942 )
1999
39
Apoptosis in primary cutaneous amyloidosis. ( 10733268 )
1999
40
Cytokeratins in primary cutaneous amyloidosis. ( 9611375 )
1998
41
Primary cutaneous amyloidosis. ( 20944287 )
1997
42
Detection of Epstein-Barr virus in primary cutaneous amyloidosis. ( 9217811 )
1997
43
Genetic heterogeneity of familial primary cutaneous amyloidosis: lack of evidence for linkage with the chromosome 10 pericentromeric region in Chinese families. ( 8752835 )
1996
44
Epstein-Barr virus-related primary cutaneous amyloidosis. Successful treatment with acyclovir and interferon-alpha. ( 8745909 )
1996
45
Diffuse primary cutaneous amyloidosis. ( 1476924 )
1992
46
Unusual manifestations of primary cutaneous amyloidosis in association with Raynaud's phenomenon and livedo reticularis. ( 1516235 )
1992
47
Partial amino acid sequence of an amyloid fibril protein from nodular primary cutaneous amyloidosis showing homology to lambda immunoglobulin light chain of variable subgroup III (a lambda III). ( 2117035 )
1990
48
Primary cutaneous amyloidosis of the auricular concha. ( 3279082 )
1988
49
A monoclonal anti-keratin antibody reactive with amyloid deposit of primary cutaneous amyloidosis. ( 2449480 )
1987
50
Primary cutaneous amyloidosis. ( 3553043 )
1987

Variations for Primary Cutaneous Amyloidosis

Expression for Primary Cutaneous Amyloidosis

Search GEO for disease gene expression data for Primary Cutaneous Amyloidosis.

Pathways for Primary Cutaneous Amyloidosis

Pathways related to Primary Cutaneous Amyloidosis according to KEGG:

37
# Name Kegg Source Accession
1 Cytokine-cytokine receptor interaction hsa04060
2 Jak-STAT signaling pathway hsa04630

Pathways related to Primary Cutaneous Amyloidosis according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 CALM1 CALM2 CALM3 CCL2 IL31 IL31RA
2
Show member pathways
13.15 CALM1 CALM2 CALM3 KRT10 KRT14 KRT16
3
Show member pathways
12.81 CALM1 CALM2 CALM3 MYLK TNNT1
4
Show member pathways
12.78 CALM1 CALM2 CALM3 KRT10 KRT14 KRT16
5
Show member pathways
12.39 CALM1 CALM2 CALM3 MYLK
6
Show member pathways
12.38 CALM1 CALM2 CALM3 MYLK
7 12.35 KRT10 KRT17 KRT18 KRT19 KRT5 KRT7
8
Show member pathways
12.29 CALM1 CALM2 CALM3 MYLK
9
Show member pathways
12.18 CALM1 CALM2 CALM3 MYLK
10
Show member pathways
12.12 CALM1 CALM2 CALM3 MYLK
11
Show member pathways
12.06 KRT10 KRT14 KRT16 KRT17 KRT18 KRT19
12 12.04 CALM1 CALM2 CALM3 CCL2
13 12.02 CALM1 CALM2 CALM3 MYLK
14
Show member pathways
11.9 CALM1 CALM2 CALM3
15 11.88 CALM1 CALM2 CALM3
16 11.88 CALM1 CALM2 CALM3
17
Show member pathways
11.85 CALM1 CALM2 CALM3
18
Show member pathways
11.83 CALM1 CALM2 CALM3
19
Show member pathways
11.82 CALM1 CALM2 CALM3
20 11.76 KRT14 KRT17 KRT5
21
Show member pathways
11.74 CALM1 CALM2 CALM3
22
Show member pathways
11.73 CALM1 CALM2 CALM3
23
Show member pathways
11.72 CALM1 CALM2 CALM3
24 11.71 CALM1 CALM2 CALM3
25
Show member pathways
11.7 CALM1 CALM2 CALM3
26 11.69 CALM1 CALM2 CALM3
27
Show member pathways
11.64 CALM1 CALM2 CALM3
28 11.62 CALM1 CALM2 CALM3
29 11.6 CALM1 CALM2 CALM3
30
Show member pathways
11.58 CALM1 CALM2 CALM3
31 11.49 CALM1 CALM2 CALM3
32 11.47 CALM1 CALM2 CALM3 MYLK
33 11.31 CALM1 CALM2 CALM3
34 11.29 CALM1 CALM2 CALM3
35 11.27 CALM1 CALM2 MYLK
36
Show member pathways
11.26 KRT14 KRT16 KRT17 KRT18 KRT19 KRT5
37 11.24 CALM1 CALM2 CALM3
38 11.23 CALM1 CALM2 CALM3 MYLK
39 11.2 CALM1 CALM2 CALM3
40 11.16 CALM1 CALM2 CALM3
41 11.15 CALM1 CALM2 CALM3
42 11.13 CALM1 CALM2 CALM3
43 11 CALM1 CALM2 CALM3
44 10.91 CALM1 CALM2 CALM3
45 10.89 CALM1 CALM2 CALM3
46 10.69 CALM1 CALM2 CALM3

GO Terms for Primary Cutaneous Amyloidosis

Cellular components related to Primary Cutaneous Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 CALM1 CALM2 CALM3 KRT10 KRT14 KRT16
2 cell periphery GO:0071944 9.62 KRT17 KRT18 KRT19 KRT8
3 sarcomere GO:0030017 9.61 CALM1 CALM2 CALM3
4 spindle microtubule GO:0005876 9.58 CALM1 CALM2 CALM3
5 calcium channel complex GO:0034704 9.54 CALM1 CALM2 CALM3
6 dystrophin-associated glycoprotein complex GO:0016010 9.46 KRT19 KRT8
7 catalytic complex GO:1902494 9.43 CALM1 CALM2 CALM3
8 keratin filament GO:0045095 9.35 KRT14 KRT18 KRT5 KRT7 KRT8
9 intermediate filament GO:0005882 9.28 KRT10 KRT14 KRT16 KRT17 KRT18 KRT19

Biological processes related to Primary Cutaneous Amyloidosis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.87 KRT14 KRT16 KRT17 KRT5
2 response to calcium ion GO:0051592 9.8 CALM1 CALM2 CALM3
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.79 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.78 CALM1 CALM2 CALM3
5 sarcomere organization GO:0045214 9.77 KRT19 KRT8 TNNT1
6 regulation of cytokinesis GO:0032465 9.77 CALM1 CALM2 CALM3
7 regulation of heart rate GO:0002027 9.76 CALM1 CALM2 CALM3
8 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.75 CALM1 CALM2 CALM3
9 positive regulation of protein autophosphorylation GO:0031954 9.73 CALM1 CALM2 CALM3
10 positive regulation of protein dephosphorylation GO:0035307 9.72 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.71 CALM1 CALM2 CALM3
12 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.7 CALM1 CALM2 CALM3
13 regulation of cardiac muscle contraction GO:0055117 9.69 CALM1 CALM2 CALM3
14 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.67 CALM1 CALM2 CALM3
15 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.65 CALM1 CALM2 CALM3
16 hair cycle GO:0042633 9.64 KRT14 KRT16
17 hemidesmosome assembly GO:0031581 9.63 KRT14 KRT5
18 hepatocyte apoptotic process GO:0097284 9.63 KRT18 KRT8
19 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.63 CALM1 CALM2 CALM3
20 cell differentiation involved in embryonic placenta development GO:0060706 9.62 KRT19 KRT8
21 detection of calcium ion GO:0005513 9.61 CALM1 CALM2 CALM3
22 keratinization GO:0031424 9.61 KRT10 KRT14 KRT16 KRT17 KRT18 KRT19
23 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.58 CALM1 CALM2 CALM3
24 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.54 CALM1 CALM2 CALM3
25 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.5 CALM1 CALM2 CALM3
26 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.43 CALM1 CALM2 CALM3
27 positive regulation of cyclic nucleotide metabolic process GO:0030801 9.33 CALM1 CALM2 CALM3
28 cornification GO:0070268 9.28 KRT10 KRT14 KRT16 KRT17 KRT18 KRT19

Molecular functions related to Primary Cutaneous Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.65 KRT14 KRT16 KRT17 KRT19 KRT5
2 scaffold protein binding GO:0097110 9.63 KRT18 KRT5 KRT8
3 structural molecule activity GO:0005198 9.63 KRT10 KRT16 KRT17 KRT18 KRT7 KRT8
4 disordered domain specific binding GO:0097718 9.61 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
6 titin binding GO:0031432 9.54 CALM1 CALM2 CALM3
7 adenylate cyclase binding GO:0008179 9.5 CALM1 CALM2 CALM3
8 calcium channel inhibitor activity GO:0019855 9.48 CALM1 CALM2
9 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
10 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Primary Cutaneous Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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