MCID: PRM155
MIFTS: 34

Primary Cutaneous Anaplastic Large Cell Lymphoma

Categories: Blood diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Primary Cutaneous Anaplastic Large Cell Lymphoma

MalaCards integrated aliases for Primary Cutaneous Anaplastic Large Cell Lymphoma:

Name: Primary Cutaneous Anaplastic Large Cell Lymphoma 58
Lymphoma, Primary Cutaneous Anaplastic Large Cell 70
Regressive Atypical Histiocytosis 58
Primary C-Alcl 58

Characteristics:

Orphanet epidemiological data:

58
primary cutaneous anaplastic large cell lymphoma
Age of onset: Adolescent,Adult,Childhood; Age of death: adult;

Classifications:

Orphanet: 58  
Rare skin diseases
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C86.6
UMLS via Orphanet 71 C1301362 C1698767
Orphanet 58 ORPHA300865
UMLS 70 C1301362

Summaries for Primary Cutaneous Anaplastic Large Cell Lymphoma

MalaCards based summary : Primary Cutaneous Anaplastic Large Cell Lymphoma, also known as lymphoma, primary cutaneous anaplastic large cell, is related to lymphoproliferative syndrome and anaplastic large cell lymphoma. An important gene associated with Primary Cutaneous Anaplastic Large Cell Lymphoma is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are T cell receptor signaling pathway and NF-kappaB Signaling. The drugs Methotrexate and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include t cells, neutrophil and myeloid.

Related Diseases for Primary Cutaneous Anaplastic Large Cell Lymphoma

Diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 lymphoproliferative syndrome 30.9 TIA1 PTPRC ALK
2 anaplastic large cell lymphoma 30.4 TIA1 PTPRC NPM1 MUC1 GZMB ALK
3 mycosis fungoides 30.4 TRG TIA1 GZMB ALK
4 lymphoma 30.3 TIA1 PTPRC NPM1 IRF4 GZMB ALK
5 peripheral t-cell lymphoma 30.2 TIA1 PTPRC GZMB ALK
6 lymphoma, hodgkin, classic 30.2 TIA1 PTPRC IRF4 GZMB ALK
7 diffuse large b-cell lymphoma 30.1 PTPRC IRF4 ALK
8 lymphomatoid papulosis 30.1 TYK2 TIA1 NPM1 GZMB ALK
9 histiocytosis 30.0 PTPRC ALK
10 lymphoma, non-hodgkin, familial 29.7 PTPRC NPM1 IRF4 GZMB ALK
11 b-cell lymphoma 29.6 TIA1 PTPRC NPM1 IRF4 ALK
12 leukemia, chronic myeloid 29.6 PTPRC IRF4 GZMB
13 cutaneous t cell lymphoma 10.6
14 human herpesvirus 8 10.4
15 keratosis 10.4
16 squamous cell carcinoma 10.4
17 erythema nodosum 10.3
18 rapidly involuting congenital hemangioma 10.3
19 basal cell carcinoma 10.3
20 dermatitis 10.3
21 keratoacanthoma 10.3
22 breast lymphoma 10.2 IRF4 ALK
23 carbapenem allergy 10.2 GZMB ALK
24 adult lymphoma 10.2 IRF4 ALK
25 lung sarcomatoid carcinoma 10.2 MUC1 ALK
26 heart lymphoma 10.2 PTPRC ALK
27 kaposi sarcoma 10.2
28 myeloma, multiple 10.2
29 dermatitis, atopic 10.2
30 hepatitis c virus 10.2
31 peripheral vascular disease 10.2
32 angiosarcoma 10.2
33 disease by infectious agent 10.2
34 hemophagocytic lymphohistiocytosis 10.2
35 mantle cell lymphoma 10.2
36 hereditary lymphedema i 10.2
37 anogenital venereal wart 10.2
38 chlamydia 10.2
39 vascular disease 10.2
40 melanoma 10.2
41 maxillary sinusitis 10.2
42 relapsing-remitting multiple sclerosis 10.2
43 cellulitis 10.2
44 pyoderma 10.2
45 superficial basal cell carcinoma 10.2
46 seminoma 10.2
47 localized scleroderma 10.2
48 pyoderma gangrenosum 10.2
49 myeloid leukemia 10.2
50 actinic keratosis 10.2

Graphical network of the top 20 diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma:



Diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma

Symptoms & Phenotypes for Primary Cutaneous Anaplastic Large Cell Lymphoma

Drugs & Therapeutics for Primary Cutaneous Anaplastic Large Cell Lymphoma

Drugs for Primary Cutaneous Anaplastic Large Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
3
Bexarotene Approved, Investigational Phase 3 153559-49-0 82146
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
5 Folic Acid Antagonists Phase 3
6 Vitamin B9 Phase 3
7 Antirheumatic Agents Phase 3
8 Immunosuppressive Agents Phase 3
9 Vitamin B Complex Phase 3
10 Dermatologic Agents Phase 3
11 Folate Phase 3
12 Antimetabolites Phase 3
13
Lenalidomide Approved Phase 2 191732-72-6 216326
14 Immunologic Factors Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Immunoconjugates Phase 2
17 Antineoplastic Agents, Immunological Phase 2
18 Antibodies Phase 2
19 Immunoglobulins Phase 2
20 Immunoglobulins, Intravenous Phase 2
21 Antibodies, Monoclonal Phase 2
22
Methylcobalamin Approved, Investigational Phase 1 13422-55-4
23
Hydroxocobalamin Approved Phase 1 13422-51-0 11953898 15589840
24
Cyanocobalamin Approved, Nutraceutical Phase 1 68-19-9 44176380
25
Aminopterin Investigational, Withdrawn Phase 1 54-62-6 2154
26
Cobalamin Experimental Phase 1 13408-78-1 6857388
27 Nutrients Phase 1
28 Micronutrients Phase 1
29 Trace Elements Phase 1
30 Vitamins Phase 1
31 10-deazaaminopterin Phase 1
32 Hematinics Phase 1
33 Vitamin B12 Phase 1
34 Vitamin B 12 Phase 1
35
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
36
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
37 Trientine
38 Calciferol
39 Hormones
40 Calcium, Dietary
41
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Open-Label, Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Patients With CD30-Positive Cutaneous T-Cell Lymphoma Completed NCT01578499 Phase 3 Brentuximab Vedotin;Methotrexate;Bexarotene
2 A Phase II Multi-Dose Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma, Large Cell Transformation of Mycosis Fungoides, and Lymphomatoid Papulosis Completed NCT00099255 Phase 2 SGN-30
3 A Phase II Study of Brentuximab Vedotin and Lenalidomide in Relapsed and Refractory T-Cell Lymphomas Recruiting NCT03409432 Phase 2 Brentuximab Vedotin;Lenalidomide
4 Phase II Trial of Brentuximab Vedotin (SGN-35) at Dose of 1.8 mg/kg IV Every 3 Weeks in Patients With CD30-positive Lymphoproliferative Disorders (Cutaneous Anaplastic Large T-cell Lymphoma (ALCL), Mycosis Fungoides, and Extensive Lymphomatoid Papulosis (LyP) Active, not recruiting NCT01352520 Phase 2 SGN-35
5 An Open-label, Fixed-dose, Multicenter, Phase II Study of MDX-060 in Patients With Relapsed or Refractory Classic Systemic or Primary Cutaneous Anaplastic Large Cell Lymphoma Withdrawn NCT00298467 Phase 2 MDX-060
6 Multicentre Phase I Trial of Engineered T Cells for Patients With Relapsed or Refractory Primary Cutaneous CD30+ Large T Cell Lymphoma or Transformed CD30+ Mycosis Fungoides Unknown status NCT01645293 Phase 1
7 A Phase 1, Open-label, Dose-finding Study of Pralatrexate Plus Systemic Bexarotene in Patients With Relapsed or Refractory Cutaneous T Cell Lymphoma Completed NCT01134341 Phase 1 Pralatrexate Injection;Bexarotene Capsules
8 A Pilot Feasibility Trial of the Tolerability of Oral Salvia Hispanica and Its Effect on Blood Fatty Acids and Stool Microbiome in Patients With Treated Non-Hodgkin Lymphoma Completed NCT02652715
9 Effect of Vitamin D Replacement on Tumor Response and Survival Parameters for Vitamin D Insufficient Patients With Cancer Recruiting NCT01787409

Search NIH Clinical Center for Primary Cutaneous Anaplastic Large Cell Lymphoma

Genetic Tests for Primary Cutaneous Anaplastic Large Cell Lymphoma

Anatomical Context for Primary Cutaneous Anaplastic Large Cell Lymphoma

MalaCards organs/tissues related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

40
T Cells, Neutrophil, Myeloid, Endothelial

Publications for Primary Cutaneous Anaplastic Large Cell Lymphoma

Articles related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

(show top 50) (show all 255)
# Title Authors PMID Year
1
Disseminated indolent ALK-positive primary cutaneous anaplastic large cell lymphoma (C-ALCL) lasting for 10 years. 61
33249555 2021
2
Pediatric primary cutaneous anaplastic large cell lymphoma treated with brachytherapy. 61
33742487 2021
3
Is immunohistochemical expression of GATA3 helpful in the differential diagnosis of transformed mycosis fungoides and primary cutaneous CD30-positive T cell lymphoproliferative disorders? 61
33604757 2021
4
The importance of differentiating between mycosis fungoides with CD30-positive large cell transformation and mycosis fungoides with coexistent primary cutaneous anaplastic large cell lymphoma. 61
32334059 2021
5
Most rare subtypes of cutaneous lymphoma display variable CD30 expression. Analysis of the German Cutaneous Lymphoma Network. 61
33480069 2021
6
Cutaneous intralymphatic anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma arising in a patient with multiple rounds of breast implants. 61
33314229 2020
7
Brentuximab Vedotin for Treating Relapsed or Refractory CD30-Positive Cutaneous T-Cell Lymphoma: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. 61
32207075 2020
8
Primary cutaneous anaplastic large cell lymphoma in a 5-year-old child: A diagnostic challenge. 61
32794314 2020
9
Primary cutaneous anaplastic large-cell lymphoma of the eyelid: report of two cases and review of the literature. 61
32998605 2020
10
Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma: A Rare Association With Large Plaque Parapsoriasis. 61
33269156 2020
11
Primary cutaneous anaplastic large cell lymphoma and evolving clinical practice: 26 years of skin lesions with locoregional progression to systemic disease. 61
32397855 2020
12
Primary Cutaneous CD30+ Lymphoproliferative Disorders: a Comprehensive Review. 61
32435988 2020
13
Primary cutaneous peripheral T-cell lymphoma, not otherwise specified, associated with lymphomatoid papulosis after a 9-year follow up: A case report. 61
32323371 2020
14
A primary cutaneous anaplastic large cell lymphoma mimicking labial herpes. 61
31858304 2020
15
Clinical, Histologic, and Molecular Characteristics of Anaplastic Lymphoma Kinase-positive Primary Cutaneous Anaplastic Large Cell Lymphoma. 61
32412717 2020
16
Primary cutaneous anaplastic large cell lymphoma with rapid liver infiltration after spontaneous resolution of the primary lesion. 61
32141106 2020
17
Prognostic factors in patients with primary cutaneous anaplastic large cell lymphoma: a multicentric, retrospective analysis of the Spanish Group of Cutaneous Lymphoma. 61
31591786 2020
18
Radiotherapy of primary cutaneous anaplastic large cell lymphoma: our experience in 30 cases. 61
31916593 2020
19
Low-dose Methotrexate Treatment for Solitary or Localized Primary Cutaneous Anaplastic Large Cell Lymphoma: A Long-term Follow-up Study. 61
31996929 2020
20
Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in the Elderly and the Importance of Sport Activity Training. 61
32013101 2020
21
Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together. 61
31664155 2020
22
Evidence linking atopy and staphylococcal superantigens to the pathogenesis of lymphomatoid papulosis, a recurrent CD30+ cutaneous lymphoproliferative disorder. 61
32049976 2020
23
Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation. 61
32509362 2020
24
The expressions of MUM-1 and Bcl-6 in ALK-negative systemic anaplastic large cell lymphoma with skin involvement and primary cutaneous anaplastic large cell lymphoma. 61
32782689 2020
25
Sarcomatoid Variant of Primary Cutaneous Anaplastic Large Cell Lymphoma. 61
31268929 2019
26
Corresponding anaplastic lymphoma kinase-tropomyosin 3 (ALK-TPM3) fusion in a patient with a primary cutaneous anaplastic large-cell lymphoma and a Spitz nevus. 61
31687467 2019
27
Molluscum contagiosum infection with features of primary cutaneous anaplastic large cell lymphoma. 61
32045148 2019
28
18F-FDG PET/CT in Lymphomatoid Papulosis Mimicking Primary Cutaneous Anaplastic Large Cell Lymphoma. 61
31246687 2019
29
Mycosis Fungoides Associated With Lesions in the Spectrum of Primary Cutaneous CD30+ Lymphoproliferative Disorders: The Same Process or 3 Coexisting Lymphomas? 61
30946099 2019
30
Clear Cell Primary Cutaneous Anaplastic Large Cell Lymphoma. 61
30946100 2019
31
Clinicopathologic and microenvironmental analysis of primary cutaneous CD30-positive lymphoproliferative disorders: a 26 year experience from an academic medical center in Brazil. 61
31640798 2019
32
Lymphomatoid Papulosis and Other Lymphoma-Like Diseases. 61
31466587 2019
33
Combined Modality Treatment With Brentuximab Vedotin and Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Report. 61
32300458 2019
34
Diffuse Primary Cutaneous Anaplastic Large Cell Lymphoma Treated by Rotational Total Skin Electron Beam Radiotherapy with Custom Shielding: Case Report. 61
31213358 2019
35
Recent Advances in Cutaneous T-cell Lymphoma: Diagnostic and Prognostic Considerations. 61
31352988 2019
36
How I treat primary cutaneous CD30+ lymphoproliferative disorders. 61
31164331 2019
37
Treatment of primary cutaneous anaplastic large cell lymphoma. 61
31256561 2019
38
Non-implant associated primary cutaneous anaplastic large cell lymphoma of the breast. 61
31086652 2019
39
Complete Resolution of Primary Cutaneous Anaplastic Large Cell Lymphoma With Topical Imiquimod 61
31141854 2019
40
Existing and Emerging Therapies for Cutaneous T-Cell Lymphoma. 61
30943788 2019
41
Primary Cutaneous Anaplastic Large-Cell Lymphoma. 61
31700858 2019
42
Acitretin combined with NB-UVB in the treatment of cutaneous CD30-positive anaplastic large cell lymphoma. 61
30659723 2019
43
Antibody-Based Therapies for Cutaneous T-Cell Lymphoma. 61
30430444 2019
44
Local radiation for cutaneous T-cell lymphoma other than mycosis fungoides and Sézary syndrome. 61
30180750 2019
45
The spectrum of CD30+ T cell lymphoproliferative disorders in the skin. 61
30691273 2019
46
Primary cutaneous CD8+ and CD30+ T-cell lymphoproliferative disorders: case reports and clinical implications. 61
30670369 2019
47
CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies. 61
30630983 2019
48
CD30-Positive Lymphoproliferative Disorders. 61
30596222 2019
49
Primary Cutaneous Anaplastic Large Cell Lymphoma of the Oral Cavity Successfully Treated with Brentuximab Vedotin. 61
31637066 2019
50
Primary multifocal anaplastic large cell lymphoma with eyelid involvement: a case report. 61
31531544 2019

Variations for Primary Cutaneous Anaplastic Large Cell Lymphoma

Expression for Primary Cutaneous Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous Anaplastic Large Cell Lymphoma.

Pathways for Primary Cutaneous Anaplastic Large Cell Lymphoma

GO Terms for Primary Cutaneous Anaplastic Large Cell Lymphoma

Biological processes related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 TYK2 MUC1 IRF4
2 T cell activation GO:0042110 8.96 PTPRC IRF4
3 positive regulation of interleukin-2 production GO:0032743 8.62 PTPRC IRF4

Sources for Primary Cutaneous Anaplastic Large Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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