MCID: PRM299
MIFTS: 35

Primary Cutaneous B-Cell Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Primary Cutaneous B-Cell Lymphoma

MalaCards integrated aliases for Primary Cutaneous B-Cell Lymphoma:

Name: Primary Cutaneous B-Cell Lymphoma 58

Classifications:

Orphanet: 58  
Rare skin diseases
Rare haematological diseases


External Ids:

UMLS via Orphanet 72 C1274310
Orphanet 58 ORPHA178563

Summaries for Primary Cutaneous B-Cell Lymphoma

MalaCards based summary : Primary Cutaneous B-Cell Lymphoma is related to lymphoblastic lymphoma and follicular lymphoma. An important gene associated with Primary Cutaneous B-Cell Lymphoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. Affiliated tissues include b cells, t cells and skin, and related phenotypes are Synthetic lethal with gemcitabine and hematopoietic system

Related Diseases for Primary Cutaneous B-Cell Lymphoma

Diseases in the Cutaneous T Cell Lymphoma family:

Primary Cutaneous B-Cell Lymphoma Primary Cutaneous Gamma/delta-Positive T-Cell Lymphoma
Primary Cutaneous T-Cell Lymphoma

Diseases related to Primary Cutaneous B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 lymphoblastic lymphoma 30.5 PAX5 CDKN2B BCL6
2 follicular lymphoma 30.4 PAX5 MS4A1 CD55 BCL6
3 leukemia, acute lymphoblastic 3 30.2 PAX5 CDKN2B CDKN2A
4 lymphoma, hodgkin, classic 30.2 PAX5 MS4A1 IL2 BCL6
5 mycosis fungoides 29.7 IL2 IFNA2 CDKN2B
6 lymphoma 29.7 PRDM1 PAX5 MS4A1 MIR17HG IL2 CDKN2B
7 b-cell lymphoma 29.5 PRDM1 POU2F2 PAX5 MS4A1 MIR17HG CDKN2B
8 plasmacytoma 28.9 VEGFA PRDM1 PAX5 IL2 CDKN2A
9 diffuse large b-cell lymphoma 28.9 VEGFA PTEN PRDM1 PAX5 MIR17HG CDKN2A
10 basal cell carcinoma 28.8 VEGFA PTEN IL2 CDKN2B CDKN2A
11 mantle cell lymphoma 27.3 VEGFA PTEN PRDM1 PAX5 MS4A1 MIR17HG
12 leukemia, chronic lymphocytic 26.7 VEGFA PTEN PAX5 MS4A1 MIR17HG IL2
13 lymphoma, non-hodgkin, familial 25.9 VEGFA PTEN PRDM1 POU2F2 PAX5 MS4A1
14 indolent primary cutaneous b-cell lymphoma 12.8
15 aggressive primary cutaneous b-cell lymphoma 12.6
16 primary cutaneous follicle center lymphoma 11.9
17 marginal zone b-cell lymphoma 10.8
18 primary cutaneous marginal zone b-cell lymphoma 10.7
19 primary cutaneous diffuse large b-cell lymphoma, leg type 10.5
20 septate uterus 10.4 KDR FLT1
21 angiokeratoma of mibelli 10.4 KDR FLT1
22 thyroid lymphoma 10.4 CDKN2B CDKN2A
23 nodular lymphocyte predominant hodgkin lymphoma 10.3 PAX5 BCL6
24 cutaneous t cell lymphoma 10.3
25 primary cutaneous lymphoma 10.3
26 bone lymphoma 10.3 PAX5 BCL6
27 lung lymphoma 10.3 PAX5 BCL6
28 fibrosarcoma of bone 10.3 KDR CDKN2A
29 intravascular large b-cell lymphoma 10.3
30 paranasal sinus lymphoma 10.3 PAX5 BCL6
31 b-cell non-hodgkin lymphoma 10.3 MS4A1 BCL6
32 tenosynovial giant cell tumor 10.3 CDKN2B CDKN2A
33 gray zone lymphoma 10.3 PAX5 BCL6
34 anemia, autoimmune hemolytic 10.3 IL2 CD59 CD55
35 t-cell/histiocyte rich large b cell lymphoma 10.3 POU2F2 BCL6
36 composite lymphoma 10.2 PAX5 BCL6
37 penile disease 10.2 IL2 IFNA2 CDKN2A
38 gallbladder small cell carcinoma 10.2 VEGFA CDKN2A
39 tracheal lymphoma 10.2 PAX5 BCL6
40 lipodermatosclerosis 10.2 VEGFA FLT1
41 glomeruloid hemangioma 10.2 VEGFA FLT1
42 infiltrating angiolipoma 10.2 VEGFA CDKN2A
43 primary central nervous system lymphoma 10.2 PAX5 BCL6
44 cancer-associated retinopathy 10.2 VEGFA FLT1
45 radiation proctitis 10.2 VEGFA KDR
46 retinoblastoma 10.1
47 human herpesvirus 8 10.1
48 lymphoproliferative syndrome 10.1
49 lyme disease 10.1
50 hepatitis c 10.1

Graphical network of the top 20 diseases related to Primary Cutaneous B-Cell Lymphoma:



Diseases related to Primary Cutaneous B-Cell Lymphoma

Symptoms & Phenotypes for Primary Cutaneous B-Cell Lymphoma

GenomeRNAi Phenotypes related to Primary Cutaneous B-Cell Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with gemcitabine GR00225-A 8.8 CDKN2A FLT1 KDR

MGI Mouse Phenotypes related to Primary Cutaneous B-Cell Lymphoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.32 BCL6 CD55 CD59 CDKN2A CDKN2B FLT1
2 cellular MP:0005384 10.25 BCL6 CD59 CDKN2A CDKN2B FLT1 IL2
3 homeostasis/metabolism MP:0005376 10.23 BCL6 CD59 CDKN2A CDKN2B FLT1 IL2
4 immune system MP:0005387 10.21 BCL6 CDKN2A CDKN2B FLT1 IL2 KDR
5 cardiovascular system MP:0005385 10.18 BCL6 CDKN2A FLT1 IL2 KDR PAX5
6 mortality/aging MP:0010768 10.15 BCL6 CD59 CDKN2A CDKN2B FLT1 IL2
7 endocrine/exocrine gland MP:0005379 10.1 BCL6 CD59 CDKN2A CDKN2B IL2 PRDM1
8 liver/biliary system MP:0005370 9.95 BCL6 CDKN2A IL2 KDR PRDM1 PTEN
9 muscle MP:0005369 9.92 BCL6 CDKN2A FLT1 KDR PAX5 PRDM1
10 neoplasm MP:0002006 9.8 CDKN2A CDKN2B IL2 PAX5 PRDM1 PTEN
11 no phenotypic analysis MP:0003012 9.7 BCL6 CDKN2A CDKN2B IL2 KDR PRDM1
12 reproductive system MP:0005389 9.61 BCL6 CD59 CDKN2A CDKN2B FLT1 IL2
13 respiratory system MP:0005388 9.17 BCL6 CDKN2A IL2 KDR POU2F2 PTEN

Drugs & Therapeutics for Primary Cutaneous B-Cell Lymphoma

Search Clinical Trials , NIH Clinical Center for Primary Cutaneous B-Cell Lymphoma

Genetic Tests for Primary Cutaneous B-Cell Lymphoma

Anatomical Context for Primary Cutaneous B-Cell Lymphoma

MalaCards organs/tissues related to Primary Cutaneous B-Cell Lymphoma:

40
B Cells, T Cells, Skin, Bone, Breast, Lung, Thyroid

Publications for Primary Cutaneous B-Cell Lymphoma

Articles related to Primary Cutaneous B-Cell Lymphoma:

(show top 50) (show all 228)
# Title Authors PMID Year
1
De-escalated radiotherapy for indolent primary cutaneous B-cell lymphoma. 61
31758232 2020
2
Cutaneous spindled follicle center cell lymphoma with abundant mucin: A diagnostic pitfall. 61
31693188 2019
3
Acquired N-Linked Glycosylation Motifs in B-Cell Receptors of Primary Cutaneous B-Cell Lymphoma and the Normal B-Cell Repertoire. 61
31042459 2019
4
The Utility of 18F-fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography in Cutaneous B-Cell Lymphoma. 61
31542900 2019
5
Primary cutaneous B-cell lymphoma: narrative review of the literature. 61
29144099 2019
6
Dermoscopy of Primary Cutaneous B-cell Lymphoma. 61
30984608 2019
7
Radiation therapy in indolent primary cutaneous B cell lymphoma: a single institute experience. 61
30094511 2018
8
Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma: a rare and aggressive cutaneous lymphoma. 61
30657800 2018
9
Relapse rates in patients with unilesional primary cutaneous B-cell lymphoma treated with radiation therapy: a single-institution experience. 61
29761874 2018
10
The First Year of the AEVD Primary Cutaneous Lymphoma Registry. 61
29680323 2018
11
A rare case of primary cutaneous diffuse large B-cell lymphoma, leg type. 61
30372723 2018
12
Radiotherapy in indolent primary cutaneous B-cell lymphoma. 61
29862552 2018
13
Primary cutaneous B-cell lymphoma: A single-center 5-year experience. 61
30604723 2018
14
Dermoscopy and the diagnosis of primary cutaneous B-cell lymphoma. 61
28846171 2018
15
Pachyderma in Primary Cutaneous NK and T-Cell Lymphoma and Leukemia Cutis. 61
29033820 2017
16
Primary cutaneous B-cell lymphoma: systemic spread is rare while cutaneous relapses and secondary malignancies are frequent. 61
27641754 2017
17
Necrotizing fasciitis associated with primary cutaneous B-cell lymphoma. A case report. 61
29205142 2017
18
Primary cutaneous spindle cell B cell lymphoma: A report of three cases and review of the literature. 61
28325356 2017
19
An Aggressive Primary Cutaneous Follicle Center Lymphoma With c-MYC Translocation and CDKN2A (9p21) Deletion: A Case Report and Review of the Literature. 61
27759694 2017
20
A Literature Revision in Primary Cutaneous B-cell Lymphoma. 61
28400634 2017
21
Intralesional anti-CD20 antibody for low-grade primary cutaneous B-cell lymphoma: Adverse reactions correlate with favorable clinical outcome. 61
28177583 2017
22
Differential NFATc1 Expression in Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoma and Other Forms of Cutaneous T-Cell Lymphoma and Pseudolymphoma. 61
27097342 2017
23
Primary cutaneous B-cell lymphoma and chronic leg ulcers in a patient with type 2 diabetes. 61
28567289 2017
24
Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma. 61
28065463 2017
25
Cutaneous lymphoma misdiagnosed as chronic lymphadenitis. 61
25903778 2016
26
Primary Cutaneous B-Cell Lymphoma in Young Monozygotic Twins: A Case Report. 61
27358311 2016
27
Dermoscopy of primary cutaneous B-cell lymphoma (PCBCL). 61
27646755 2016
28
Primary cutaneous B-cell lymphoma other than marginal zone: clinicopathologic analysis of 161 cases: Comparison with current classification and definition of prognostic markers. 61
27665744 2016
29
[Primary cutaneous B-cell lymphomas: study of 22 cases]. 61
27427313 2016
30
Immunocytochemical p63 expression discriminates between primary cutaneous follicle centre cell and diffuse large B cell lymphoma-leg type, and is of the TAp63 isoform. 61
26332336 2016
31
Spindle B-cell lymphoma: a rare variant of follicle center lymphoma. 61
26955785 2016
32
HPyV6, HPyV7 and TSPyV DNA sequences detection in skin disease patients and healthy subjects. 61
25809796 2016
33
Diagnostic utility of SOX11 immunohistochemistry in differentiating cutaneous spread of mantle cell lymphoma from primary cutaneous B-cell lymphomas. 61
26762898 2016
34
Intralesional Rituximab Treatment for Primary Cutaneous B-cell Lymphoma: Nine Finnish Cases. 61
26525093 2016
35
Diagnosing Spindle Cell Variant of Primary Cutaneous B-Cell Lymphoma: Potential Pitfalls and Solutions. 61
27098630 2016
36
Primary cutaneous B-cell lymphoma (non-leg type) has excellent outcomes even after very low dose radiation as single-modality therapy. 61
25860237 2016
37
Primary cutaneous lymphomas: the analysis of cases treated in the Department of Dermatology University Hospital in Krakow. 61
29676886 2016
38
Dermoscopy Pattern, Histopathology and Immunophenotype of Primary Cutaneous B-Cell Lymphoma Presenting as a Solitary Skin Nodule. 61
26694025 2016
39
Diagnosis and Management of Cutaneous B-cell Lymphoma. 61
26433853 2015
40
Primary Cutaneous B-Cell Lymphoma: Management and Patterns of Recurrence at the Multimodality Cutaneous Lymphoma Clinic of The Ohio State University. 61
26306900 2015
41
Epstein-Barr virus-positive primary cutaneous follicle centre lymphoma; an age-related phenomenon? 61
25957860 2015
42
Primary cutaneous spindle cell B-cell lymphoma of follicle origin mimicking acne rosacea. 61
25229568 2015
43
Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis. 61
25776770 2015
44
The High Expression of the microRNA 17-92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression. 61
25634356 2015
45
Clinical features and treatment outcomes of primary cutaneous B-cell lymphoma: a single-center analysis in South Korea. 61
25552248 2015
46
Primary cutaneous follicle-center lymphoma. 61
25526329 2014
47
Breast cancer mimic: cutaneous B-cell lymphoma presenting as an isolated breast mass. 61
25473394 2014
48
Rituximab in the treatment of primary cutaneous B-cell lymphoma: a review. 61
23540593 2014
49
Treatment of indolent primary cutaneous B-cell lymphomas with subcutaneous interferon-alfa. 61
24433874 2014
50
Cutaneous lymphomas. 61
24393310 2014

Variations for Primary Cutaneous B-Cell Lymphoma

Expression for Primary Cutaneous B-Cell Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous B-Cell Lymphoma.

Pathways for Primary Cutaneous B-Cell Lymphoma

Pathways related to Primary Cutaneous B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 VEGFA PTEN KDR IL2 IFNA2 FLT1
2 12.46 VEGFA PTEN IL2 IFNA2 CDKN2B CDKN2A
3
Show member pathways
12.41 VEGFA PTEN KDR BCL6
4 12.36 PRDM1 PAX5 IL2 BCL6
5 12.14 PTEN IL2 CDKN2B CDKN2A
6
Show member pathways
12.09 KDR IL2 IFNA2 FLT1
7
Show member pathways
12.03 VEGFA PTEN KDR FLT1
8
Show member pathways
11.8 VEGFA KDR FLT1
9 11.79 PTEN CDKN2A BCL6
10 11.71 MS4A1 CD59 CD55
11 11.69 MS4A1 IL2 IFNA2 CD59
12
Show member pathways
11.66 VEGFA KDR FLT1
13 11.56 MS4A1 IL2 IFNA2
14 11.49 VEGFA KDR FLT1 CDKN2A
15 11.24 VEGFA KDR FLT1
16 11.08 VEGFA KDR FLT1
17 10.71 VEGFA KDR FLT1
18 10.65 PRDM1 PAX5 MS4A1 BCL6
19
Show member pathways
10.34 VEGFA KDR FLT1

GO Terms for Primary Cutaneous B-Cell Lymphoma

Cellular components related to Primary Cutaneous B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 VEGFA PTEN KDR IL2 IFNA2 FLT1

Biological processes related to Primary Cutaneous B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 VEGFA POU2F2 PAX5 IL2 CDKN2B CDKN2A
2 negative regulation of apoptotic process GO:0043066 9.95 VEGFA PTEN KDR IL2 BCL6
3 positive regulation of cell proliferation GO:0008284 9.93 VEGFA PTEN KDR IL2 FLT1
4 cytokine-mediated signaling pathway GO:0019221 9.89 VEGFA IL2 IFNA2 BCL6
5 negative regulation of gene expression GO:0010629 9.87 VEGFA PRDM1 KDR IFNA2
6 angiogenesis GO:0001525 9.81 VEGFA PTEN KDR FLT1
7 B cell differentiation GO:0030183 9.7 MS4A1 IFNA2 BCL6
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 VEGFA IL2 IFNA2
9 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.63 PTEN CDKN2B CDKN2A
10 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.62 VEGFA FLT1
11 eye photoreceptor cell development GO:0042462 9.61 VEGFA PRDM1
12 negative regulation of phosphorylation GO:0042326 9.61 CDKN2B CDKN2A
13 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.61 VEGFA KDR FLT1
14 positive regulation of positive chemotaxis GO:0050927 9.58 VEGFA KDR
15 positive regulation of regulatory T cell differentiation GO:0045591 9.58 IL2 BCL6
16 positive regulation of cellular component movement GO:0051272 9.56 VEGFA BCL6
17 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.54 VEGFA KDR FLT1
18 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.5 PTEN CDKN2B CDKN2A
19 regulation of complement-dependent cytotoxicity GO:1903659 9.48 CD59 CD55
20 sprouting angiogenesis GO:0002040 9.43 VEGFA KDR FLT1
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 VEGFA KDR
22 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFA KDR FLT1
23 humoral immune response GO:0006959 9.26 POU2F2 PAX5 MS4A1 IFNA2
24 negative regulation of B cell apoptotic process GO:0002903 8.8 MIR17HG IL2 BCL6

Molecular functions related to Primary Cutaneous B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 9.26 VEGFA PTEN
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.16 CDKN2B CDKN2A
3 vascular endothelial growth factor binding GO:0038085 8.96 KDR FLT1
4 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 KDR FLT1

Sources for Primary Cutaneous B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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