MCID: PRM127
MIFTS: 29

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Categories: Skin diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

MalaCards integrated aliases for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type:

Name: Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type 59
Pcdlbcl,lt 59

Classifications:



External Ids:

Orphanet 59 ORPHA178544
ICD10 via Orphanet 34 C83.3

Summaries for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

MalaCards based summary : Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, also known as pcdlbcl,lt, is related to diffuse large b-cell lymphoma and b-cell lymphomas. An important gene associated with Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type is MYD88 (Myeloid Differentiation Primary Response 88), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis Modulation and Signaling. The drugs nivolumab and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and endothelial, and related phenotype is neoplasm.

Related Diseases for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Diseases related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 diffuse large b-cell lymphoma 30.7 IRF4 MYD88
2 b-cell lymphomas 30.2 CDKN2A IRF4
3 lymphoma 10.9
4 rheumatoid arthritis 10.1
5 arthritis 10.1
6 mantle cell lymphoma 10.1
7 poems syndrome 10.1
8 encephalopathy 10.1
9 endotheliitis 10.1
10 marginal zone b-cell lymphoma 9.8 IRF4 MYD88
11 colon lymphoma 9.6 CDKN2A IRF4
12 primary central nervous system lymphoma 9.5 CDKN2A MYD88
13 blastic plasmacytoid dendritic cell 9.4 CDKN2A MYD88
14 adult t-cell leukemia 9.4 CDKN2A IRF4
15 central nervous system lymphoma 9.4 CDKN2A MYD88
16 myeloma, multiple 9.0 CDKN2A IRF4

Graphical network of the top 20 diseases related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type:



Diseases related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Symptoms & Phenotypes for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

MGI Mouse Phenotypes related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 CDKN2A IRF4 MYD88

Drugs & Therapeutics for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Drugs for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulin G Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2
5 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas Recruiting NCT03038672 Phase 2 Varlilumab
2 Cell-free Circulating DNA in Primary Cutaneous Lymphomas Recruiting NCT02883517

Search NIH Clinical Center for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Genetic Tests for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Anatomical Context for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

MalaCards organs/tissues related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type:

41
B Cells, Skin, Endothelial, T Cells, Bone

Publications for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Articles related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type:

(show all 42)
# Title Authors Year
1
Molecular Mechanisms of Disease Progression in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type during Ibrutinib Therapy. ( 29899297 )
2018
2
Spontaneous Regression of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type. ( 29508000 )
2018
3
PD-L1 and PD-L2 Are Differentially Expressed by Macrophages or Tumor Cells in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. ( 29112015 )
2018
4
Spontaneous regression of primary cutaneous diffuse large B-cell lymphoma, leg type with significant T-cell immune response. ( 29693055 )
2018
5
Relapsed Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type. ( 29263555 )
2017
6
Molecular analysis of immunoglobulin variable genes supports a germinal center experienced normal counterpart in primary cutaneous diffuse large B-cell lymphoma, leg-type. ( 28838616 )
2017
7
Identification of Somatic Mutations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type by Massive Parallel Sequencing. ( 28479318 )
2017
8
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, With Spontaneous Regression After Biopsy. ( 28926365 )
2017
9
Central nervous system involvement of primary cutaneous diffuse large B-cell lymphoma, leg type: 13 cases. ( 28543967 )
2017
10
Spontaneous regression of a primary cutaneous diffuse large B-cell lymphoma, leg type. ( 27374170 )
2016
11
An 88-year-old woman with an ulcerous tumour on the leg. Primary cutaneous diffuse large-B-cell lymphoma, leg type. ( 26951356 )
2016
12
18FDG PET/CT Appearance in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. ( 25742229 )
2015
13
Skin Involvement of Mantle Cell Lymphoma May Mimic Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type. ( 26034867 )
2015
14
Atypical clinicopathologic presentation of primary cutaneous diffuse large B-cell lymphoma, leg type. ( 25824272 )
2015
15
Excellent Outcome of Immunomodulation or Bruton's Tyrosine Kinase Inhibition in Highly Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. ( 26788279 )
2015
16
Primary Cutaneous Diffuse Large B Cell Lymphoma, Leg Type (PCDLBCL-LT) in the Setting of Prior Radiation Therapy. ( 25326162 )
2014
17
High Frequency and Clinical Prognostic Value of MYD88 L265P Mutation in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg-Type. ( 25055137 )
2014
18
Improvement of survival in patients with primary cutaneous diffuse large B-cell lymphoma, leg type, in France. ( 24647650 )
2014
19
Ureteral spread of a primary cutaneous diffuse large B-cell lymphoma, leg type. ( 24744525 )
2014
20
Transient Wheal Attack Corresponding to the Tumor Lesions of Primary Cutaneous Diffuse Large B Cell Lymphoma, Leg Type after Successive Rituximab Treatment. ( 25408649 )
2014
21
Lenalidomide monotherapy in relapsed primary cutaneous diffuse large B cell lymphoma-leg type. ( 23680870 )
2014
22
Rheumatoid arthritis/methotrexate-associated primary cutaneous diffuse large B-cell lymphoma, leg type. ( 24881744 )
2014
23
Frequent relapse and irradiation strategy in primary cutaneous diffuse large B-cell lymphoma, leg-type. ( 22930184 )
2013
24
"Invisible" primary cutaneous diffuse large B-cell lymphoma, leg type, as a cause of fever of unknown origin. ( 23630209 )
2013
25
Primary cutaneous diffuse large B-cell lymphoma, leg type, with multiple local relapses: case presentation and brief review of literature. ( 24376327 )
2013
26
Primary cutaneous diffuse large B-cell lymphoma leg type presenting with hemophagocytic syndrome. ( 23062925 )
2012
27
Primary cutaneous diffuse large B-cell lymphoma, leg type: diagnostic considerations. ( 22849734 )
2012
28
MYD88 somatic mutation is a genetic feature of primary cutaneous diffuse large B-cell lymphoma, leg type. ( 22495176 )
2012
29
Acute onset of leg nodules in a sporotrichoid pattern--quiz case. Diagnosis: primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT). ( 23069960 )
2012
30
Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell lymphoma share identical clinicopathological and immunophenotypical features. ( 21816504 )
2012
31
Bone involvement in two cases of thoracic primary cutaneous diffuse large B-cell lymphoma, leg type. ( 21700538 )
2011
32
Primary cutaneous diffuse large B-cell lymphoma, leg-type, treated with a modified R-CHOP immunochemotherapy - diagnostic and therapeutic challenges. ( 21122066 )
2011
33
Primary cutaneous diffuse large B cell lymphoma, leg type. ( 21393962 )
2011
34
Co-infection of human herpesvirus-6 and human herpesvirus-8 in primary cutaneous diffuse large B-cell lymphoma, leg type. ( 21517824 )
2011
35
Primary cutaneous diffuse large B-cell lymphoma, leg type, with unusual clinical presentation of bluish-reddish multicolored rainbow pattern. ( 21444864 )
2011
36
IRF4 expression without IRF4 rearrangement is a general feature of primary cutaneous diffuse large B-cell lymphoma, leg type. ( 20054341 )
2010
37
Primary cutaneous diffuse large B-cell lymphoma, leg type, with features simulating POEMS syndrome. ( 19558504 )
2010
38
Primary cutaneous diffuse large B-cell lymphoma, leg type, with expression of both vascular endothelial growth factor and its receptors. ( 19589592 )
2009
39
Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large B-cell lymphoma, leg type. ( 19020554 )
2009
40
A case of primary cutaneous diffuse large B-cell lymphoma, leg type monitored with fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography. ( 19183176 )
2009
41
Primary cutaneous diffuse large B-cell lymphoma, leg type in an elderly man with human immunodeficiency virus encephalopathy. ( 19734989 )
2009
42
Primary cutaneous diffuse large B-cell lymphoma, leg type: clinicopathologic features and prognostic analysis in 60 cases. ( 17875875 )
2007

Variations for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Expression for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Search GEO for disease gene expression data for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type.

Pathways for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Pathways related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 IRF4 MYD88
2
Show member pathways
11.5 CDKN2A IRF4 MYD88
3
Show member pathways
10.92 IRF4 MYD88

GO Terms for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

Biological processes related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.16 CDKN2A MYD88
2 cytokine-mediated signaling pathway GO:0019221 8.96 IRF4 MYD88
3 type I interferon signaling pathway GO:0060337 8.62 IRF4 MYD88

Molecular functions related to Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.62 CDKN2A IRF4

Sources for Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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