PCFCL
MCID: PRM128
MIFTS: 25

Primary Cutaneous Follicle Center Lymphoma (PCFCL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Primary Cutaneous Follicle Center Lymphoma

MalaCards integrated aliases for Primary Cutaneous Follicle Center Lymphoma:

Name: Primary Cutaneous Follicle Center Lymphoma 53 59 72
Cutaneous Follicle Centre Lymphoma 53 33
Pcfcl 53 59
Cutaneous Follicle Center Lymphoma 53
Crosti's Disease 53

Classifications:



External Ids:

ICD10 33 C82.6
ICD10 via Orphanet 34 C82.6
UMLS via Orphanet 73 C1333171 C1631066
Orphanet 59 ORPHA178540
UMLS 72 C1333171

Summaries for Primary Cutaneous Follicle Center Lymphoma

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 178540DefinitionA rare, indolent primary cutaneous B-cell lymphoma characterized by a solitary or grouped erythematous plaques or tumors, preferentially located on the head, neck or trunk region, and composed of centroblasts and centrocytes arranged in a follicular, diffuse, or mixed growth pattern. The lesions are smooth and typically do not ulcerate. The neoplastic cells express pan B cell markers and Bcl-6, and typically lack Bcl-2.Visit the Orphanet disease page for more resources.

MalaCards based summary : Primary Cutaneous Follicle Center Lymphoma, also known as cutaneous follicle centre lymphoma, is related to follicular lymphoma 1 and lymphoma. An important gene associated with Primary Cutaneous Follicle Center Lymphoma is EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit). Affiliated tissues include b cells, skin and brain.

Wikipedia : 75 Primary cutaneous follicle center lymphoma is a type of lymphoma. It was recognized as a distinct... more...

Related Diseases for Primary Cutaneous Follicle Center Lymphoma

Graphical network of the top 20 diseases related to Primary Cutaneous Follicle Center Lymphoma:



Diseases related to Primary Cutaneous Follicle Center Lymphoma

Symptoms & Phenotypes for Primary Cutaneous Follicle Center Lymphoma

Drugs & Therapeutics for Primary Cutaneous Follicle Center Lymphoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1 Multidose Study to Evaluate the Safety and Tolerability of XmAb13676 in Patients With CD20-Expressing Hematologic Malignancies Recruiting NCT02924402 Phase 1

Search NIH Clinical Center for Primary Cutaneous Follicle Center Lymphoma

Genetic Tests for Primary Cutaneous Follicle Center Lymphoma

Anatomical Context for Primary Cutaneous Follicle Center Lymphoma

MalaCards organs/tissues related to Primary Cutaneous Follicle Center Lymphoma:

41
B Cells, Skin, Brain, Lymph Node, Breast

Publications for Primary Cutaneous Follicle Center Lymphoma

Articles related to Primary Cutaneous Follicle Center Lymphoma:

(show top 50) (show all 114)
# Title Authors PMID Year
1
Macular presentation of primary cutaneous follicle center lymphoma with an intermittent clinical course. 38
31389373 2019
2
Primary cutaneous B-cell lymphoma: narrative review of the literature. 38
29144099 2019
3
Primary cutaneous large B-cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases. 38
30715765 2019
4
Acquired N-Linked Glycosylation Motifs in B-Cell Receptors of Primary Cutaneous B-Cell Lymphoma and the Normal B-Cell Repertoire. 38
31042459 2019
5
Primary cutaneous vs secondary cutaneous follicular lymphomas: A comparative study focused on BCL2, CD10, and t(14;18) expression. 38
30511443 2019
6
Cutaneous B-Cell Lymphoma. 38
30497672 2019
7
Primary Cutaneous Follicle Center Lymphoma of the Eyelid: A Case Report and Review of the Literature in Light of Recent Changes to the WHO Classification of Lymphoid Neoplasms. 38
30976595 2019
8
Role of imaging in low grade cutaneous B-cell lymphoma presenting in the skin. 38
30703460 2019
9
Radiation therapy in indolent primary cutaneous B cell lymphoma: a single institute experience. 38
30094511 2018
10
Primary Cutaneous Follicle Center Lymphoma. 38
30407851 2018
11
Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management. 38
30039522 2018
12
High Incidence and Clinical Significance of MYC Rearrangements in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. 38
30113335 2018
13
Primary Cutaneous Follicle Center Lymphoma Clear Cell Variant: Expanding the Spectrum of Cutaneous Clear Cell Neoplasms. 38
29877892 2018
14
Outcomes of radiation therapy of indolent cutaneous B-cell lymphomas and literature review. 38
29578630 2018
15
Concomitant 1p36 deletion and TNFRSF14 mutations in primary cutaneous follicle center lymphoma frequently expressing high levels of EZH2 protein. 38
29858685 2018
16
Helicobacter pylori eradication may successfully treat primary cutaneous follicle center lymphoma. 38
29897650 2018
17
Primary cutaneous B-cell lymphoma: A single-center 5-year experience. 38
30604723 2018
18
Primary cutaneous B-cell lymphomas- clinical and histopathologic features, differential diagnosis, and treatment. 38
29719020 2018
19
Primary cutaneous follicle center lymphoma mimicking folliculitis. 38
29529119 2018
20
Primary cutaneous follicle center lymphoma. 38
29166511 2017
21
Primary Cutaneous B-cell Lymphomas. 38
28802500 2017
22
Primary cutaneous large B-cell lymphoma of scalp: Case report of a rare variant. 38
28631652 2017
23
An Aggressive Primary Cutaneous Follicle Center Lymphoma With c-MYC Translocation and CDKN2A (9p21) Deletion: A Case Report and Review of the Literature. 38
27759694 2017
24
Intralesional anti-CD20 antibody for low-grade primary cutaneous B-cell lymphoma: Adverse reactions correlate with favorable clinical outcome. 38
28177583 2017
25
Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma. 38
28065463 2017
26
Cutaneous B-cell lymphomas - pathogenesis, diagnostic workup, and therapy. 38
27992127 2016
27
B-Zell-Lymphome der Haut - Pathogenese, Diagnostik und Therapie. 38
27992139 2016
28
Atypical clinical presentation of primary and secondary cutaneous follicle center lymphoma (FCL) on the head characterized by macular lesions. 38
27380773 2016
29
Cutaneous B-cell lymphomas: 2016 update on diagnosis, risk-stratification, and management. 38
27650702 2016
30
TOX expression in cutaneous B-cell lymphomas. 38
27180090 2016
31
Spindle B-cell lymphoma: a rare variant of follicle center lymphoma. 38
26955785 2016
32
Primary cutaneous follicle center lymphoma in a patient with WHIM syndrome. 38
25571909 2016
33
Primary Cutaneous Follicle Center Lymphomas Expressing BCL2 Protein Frequently Harbor BCL2 Gene Break and May Present 1p36 Deletion: A Study of 20 Cases. 38
26658664 2016
34
Primary cutaneous lymphoma in southern Brazil: a 12-year single-center experience. 38
26496535 2015
35
Primary cutaneous follicle center lymphoma associated with an extracutaneous dissemination: a cytogenetic finding of potential prognostic value. 38
26486746 2015
36
Primary Cutaneous B-Cell Lymphoma: Management and Patterns of Recurrence at the Multimodality Cutaneous Lymphoma Clinic of The Ohio State University. 38
26306900 2015
37
Frequency of primary cutaneous lymphoma variants in Austria: retrospective data from a dermatology referral centre between 2006 and 2013. 38
25600184 2015
38
Epstein-Barr virus-positive primary cutaneous follicle centre lymphoma; an age-related phenomenon? 38
25957860 2015
39
The High Expression of the microRNA 17-92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression. 38
25634356 2015
40
Primary cutaneous follicle center lymphoma simulating basal-cell carcinoma on the nasal ala. 38
26312690 2015
41
Diagnostic and prognostic value of BCL2 rearrangement in 53 patients with follicular lymphoma presenting as primary skin lesions. 38
25696794 2015
42
Clinical features and treatment outcomes of primary cutaneous B-cell lymphoma: a single-center analysis in South Korea. 38
25552248 2015
43
Cutaneous B-cell lymphomas: 2015 update on diagnosis, risk-stratification, and management. 38
25535037 2015
44
Primary cutaneous follicle-center lymphoma. 38
25526329 2014
45
Primary cutaneous follicle center lymphoma with Hodgkin and Reed-Sternberg-like cells: a new histopathologic variant. 38
25099172 2014
46
Primary cutaneous follicle center lymphoma with diffuse CD30 expression: a report of 4 cases of a rare variant. 38
24836545 2014
47
Primary cutaneous follicle center lymphoma with follicular mucinosis. 38
24943203 2014
48
Rituximab plus liposomal pegylated doxorubicin in the treatment of primary cutaneous B-cell lymphomas. 38
24635751 2014
49
Methotrexate-associated B-cell lymphoproliferative disorders presenting in the skin: A clinicopathologic and immunophenotypical study of 10 cases. 38
24805861 2014
50
Antinuclear antibody seropositivity in men with cutaneous B-cell lymphoma of the scalp. 38
25335355 2014

Variations for Primary Cutaneous Follicle Center Lymphoma

Cosmic variations for Primary Cutaneous Follicle Center Lymphoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6987441 MEF2B haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.214T>A p.Y72N 19:19149270-19149270 0

Expression for Primary Cutaneous Follicle Center Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous Follicle Center Lymphoma.

Pathways for Primary Cutaneous Follicle Center Lymphoma

GO Terms for Primary Cutaneous Follicle Center Lymphoma

Sources for Primary Cutaneous Follicle Center Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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