MCID: PRM128
MIFTS: 25

Primary Cutaneous Follicle Center Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Primary Cutaneous Follicle Center Lymphoma

MalaCards integrated aliases for Primary Cutaneous Follicle Center Lymphoma:

Name: Primary Cutaneous Follicle Center Lymphoma 54 60 74
Pcfcl 54 60
Cutaneous Follicle Center Lymphoma 54
Cutaneous Follicle Centre Lymphoma 54
Crosti's Disease 54

Classifications:



External Ids:

ICD10 34 C82.6
ICD10 via Orphanet 35 C82.6
UMLS via Orphanet 75 C1333171 C1631066
Orphanet 60 ORPHA178540
UMLS 74 C1333171

Summaries for Primary Cutaneous Follicle Center Lymphoma

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 178540Disease definitionA rare, indolent primary cutaneous B-cell lymphoma characterized by a solitary or grouped erythematous plaques or tumors, preferentially located on the head, neck or trunk region, and composed of centroblasts and centrocytes arranged in a follicular, diffuse, or mixed growth pattern. The lesions are smooth and typically do not ulcerate. The neoplastic cells express pan B cell markers and Bcl-6, and typically lack Bcl-2.Visit the Orphanet disease page for more resources.

MalaCards based summary : Primary Cutaneous Follicle Center Lymphoma, also known as pcfcl, is related to lymphoma and follicular lymphoma 1. An important gene associated with Primary Cutaneous Follicle Center Lymphoma is EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit). Affiliated tissues include b cells, skin and brain.

Wikipedia : 77 Primary cutaneous follicle center lymphoma is a type of lymphoma. It was recognized as a distinct... more...

Related Diseases for Primary Cutaneous Follicle Center Lymphoma

Diseases related to Primary Cutaneous Follicle Center Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 lymphoma 10.8
2 follicular lymphoma 1 10.7
3 lymphosarcoma 10.3
4 b-cell lymphomas 10.2
5 reticulohistiocytic granuloma 10.1
6 leukemia, chronic lymphocytic 2 10.0
7 leukemia, chronic lymphocytic 10.0
8 whim syndrome 10.0
9 basal cell carcinoma 1 10.0
10 alopecia 10.0
11 diffuse large b-cell lymphoma 10.0
12 leukemia 10.0
13 mantle cell lymphoma 10.0
14 lymphocytic leukemia 10.0
15 basal cell carcinoma 10.0
16 folliculitis 10.0
17 klatskin's tumor 10.0
18 alopecia areata 10.0
19 follicular mucinosis 10.0
20 leukemia, b-cell, chronic 10.0
21 intravascular large b-cell lymphoma 10.0
22 thrombocytosis 10.0
23 blood group, kidd system 10.0

Graphical network of the top 20 diseases related to Primary Cutaneous Follicle Center Lymphoma:



Diseases related to Primary Cutaneous Follicle Center Lymphoma

Symptoms & Phenotypes for Primary Cutaneous Follicle Center Lymphoma

Drugs & Therapeutics for Primary Cutaneous Follicle Center Lymphoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate Safety and Tolerability of XmAb13676 in Patients With CD20-expressing Hematologic Malignancies Recruiting NCT02924402 Phase 1

Search NIH Clinical Center for Primary Cutaneous Follicle Center Lymphoma

Genetic Tests for Primary Cutaneous Follicle Center Lymphoma

Anatomical Context for Primary Cutaneous Follicle Center Lymphoma

MalaCards organs/tissues related to Primary Cutaneous Follicle Center Lymphoma:

42
B Cells, Skin, Brain, Lymph Node

Publications for Primary Cutaneous Follicle Center Lymphoma

Articles related to Primary Cutaneous Follicle Center Lymphoma:

(show all 35)
# Title Authors Year
1
Primary Cutaneous Follicle Center Lymphoma of the Eyelid: A Case Report and Review of the Literature in Light of Recent Changes to the WHO Classification of Lymphoid Neoplasms. ( 30976595 )
2019
2
Primary cutaneous follicle center lymphoma mimicking folliculitis. ( 29529119 )
2018
3
Primary Cutaneous Follicle Center Lymphoma. ( 30407851 )
2018
4
Concomitant 1p36 deletion and TNFRSF14 mutations in primary cutaneous follicle center lymphoma frequently expressing high levels of EZH2 protein. ( 29858685 )
2018
5
Primary Cutaneous Follicle Center Lymphoma Clear Cell Variant: Expanding the Spectrum of Cutaneous Clear Cell Neoplasms. ( 29877892 )
2018
6
Helicobacter pylori eradication may successfully treat primary cutaneous follicle center lymphoma. ( 29897650 )
2018
7
Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma. ( 28065463 )
2017
8
An Aggressive Primary Cutaneous Follicle Center Lymphoma With c-MYC Translocation and CDKN2A (9p21) Deletion: A Case Report and Review of the Literature. ( 27759694 )
2017
9
Primary cutaneous follicle center lymphoma. ( 29166511 )
2017
10
Primary cutaneous follicle center lymphoma in a patient with WHIM syndrome. ( 25571909 )
2016
11
Primary cutaneous follicle center lymphoma simulating basal-cell carcinoma on the nasal ala. ( 26312690 )
2015
12
Primary cutaneous follicle center lymphoma associated with an extracutaneous dissemination: a cytogenetic finding of potential prognostic value. ( 26486746 )
2015
13
Primary cutaneous follicle center lymphoma with follicular mucinosis. ( 24943203 )
2014
14
Primary cutaneous follicle center lymphoma arising adjacent to silicone breast implant. ( 24321100 )
2014
15
Primary cutaneous follicle center lymphoma, diffuse type, with atypical clinical features. ( 24776734 )
2014
16
Primary cutaneous follicle center lymphoma with diffuse CD30 expression: a report of 4 cases of a rare variant. ( 24836545 )
2014
17
Primary cutaneous follicle center lymphoma with Hodgkin and Reed-Sternberg-like cells: a new histopathologic variant. ( 25099172 )
2014
18
Primary cutaneous follicle-center lymphoma. ( 25526329 )
2014
19
Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor. ( 23167279 )
2013
20
Primary cutaneous follicle center lymphoma following deep brain stimulation implants. ( 23294327 )
2013
21
Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. ( 23786884 )
2013
22
Primary cutaneous follicle center lymphoma in the setting of chronic lymphocytic leukemia. ( 21508570 )
2011
23
Miliary and agminated-type primary cutaneous follicle center lymphoma: report of 18 cases. ( 21601947 )
2011
24
Clinicopathologic features of early lesions of primary cutaneous follicle center lymphoma, diffuse type: implications for early diagnosis and treatment. ( 21704419 )
2011
25
Acneiform presentation of primary cutaneous follicle center lymphoma. ( 21920255 )
2011
26
Focal rituximab-induced edematous reaction at primary cutaneous follicle center lymphoma lesions: case report and literature review. ( 21986026 )
2011
27
Primary cutaneous follicle center lymphoma responsive to interferon alfa-2a. ( 22016291 )
2011
28
Long-term evolution of an untreated primary cutaneous follicle center lymphoma of the scalp. ( 19915449 )
2010
29
IgM expression on paraffin sections distinguishes primary cutaneous large B-cell lymphoma, leg type from primary cutaneous follicle center lymphoma. ( 20551823 )
2010
30
Bcl-xL gene expression correlated with lower apoptotic cell numbers and shorter progression-free survival in PCFCL. ( 19242522 )
2009
31
Primary cutaneous follicle center lymphoma associated with alopecia areata. ( 18501107 )
2008
32
Primary cutaneous follicle center lymphoma -'crosti lymphoma': what can we learn? ( 18284269 )
2008
33
Coexistence of two discordant B-cell lymphomas in the skin and lymph node: report of a case with primary cutaneous follicle-center lymphoma and nodal mantle-cell lymphoma. ( 17596170 )
2007
34
Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID. ( 16507780 )
2006
35
Primary cutaneous follicle center lymphoma of the arm with a novel chromosomal translocation t(12;21)(q13;q22): a case report. ( 16680749 )
2006

Variations for Primary Cutaneous Follicle Center Lymphoma

Cosmic variations for Primary Cutaneous Follicle Center Lymphoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6987441 MEF2B haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.214T>A p.Y72N 19:19149270-19149270 0
2 COSM6987440 KMT2D haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.7576C>T p.Q2526* 12:49038970-49038970 0
3 COSM5597091 KMT2A haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.1432C>T p.R478* 11:118472591-118472591 0
4 COSM6987443 BTK haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.62C>A p.S21* 23:101375223-101375223 0
5 COSM6987442 BORCS8-MEF2B haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.214T>A p.Y72N 19:19149270-19149270 0
6 COSM5597090 haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.1432C>T p.R478* 11:118472591-118472591 0
7 COSM6987439 haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.8386C>T p.Q2796* 12:49038970-49038970 0

Expression for Primary Cutaneous Follicle Center Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous Follicle Center Lymphoma.

Pathways for Primary Cutaneous Follicle Center Lymphoma

GO Terms for Primary Cutaneous Follicle Center Lymphoma

Sources for Primary Cutaneous Follicle Center Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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