PCFCL
MCID: PRM128
MIFTS: 25

Primary Cutaneous Follicle Center Lymphoma (PCFCL)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Primary Cutaneous Follicle Center Lymphoma

MalaCards integrated aliases for Primary Cutaneous Follicle Center Lymphoma:

Name: Primary Cutaneous Follicle Center Lymphoma 52 58 71
Cutaneous Follicle Centre Lymphoma 52 32
Pcfcl 52 58
Cutaneous Follicle Center Lymphoma 52
Crosti's Disease 52

Classifications:

Orphanet: 58  
Rare skin diseases
Rare haematological diseases


External Ids:

ICD10 32 C82.6
ICD10 via Orphanet 33 C82.6
UMLS via Orphanet 72 C1333171 C1631066
Orphanet 58 ORPHA178540
UMLS 71 C1333171

Summaries for Primary Cutaneous Follicle Center Lymphoma

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 178540 Definition A rare, indolent primary cutaneous B-cell lymphoma characterized by a solitary or grouped erythematous plaques or tumors , preferentially located on the head, neck or trunk region, and composed of centroblasts and centrocytes arranged in a follicular, diffuse, or mixed growth pattern. The lesions are smooth and typically do not ulcerate. The neoplastic cells express pan B cell markers and Bcl-6, and typically lack Bcl-2. Visit the Orphanet disease page for more resources.

MalaCards based summary : Primary Cutaneous Follicle Center Lymphoma, also known as cutaneous follicle centre lymphoma, is related to follicular lymphoma 1 and lymphoma. An important gene associated with Primary Cutaneous Follicle Center Lymphoma is EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit). Affiliated tissues include b cells, skin and t cells.

Wikipedia : 74 Primary cutaneous follicle center lymphoma is a type of lymphoma. It was recognized as a distinct... more...

Related Diseases for Primary Cutaneous Follicle Center Lymphoma

Graphical network of the top 20 diseases related to Primary Cutaneous Follicle Center Lymphoma:



Diseases related to Primary Cutaneous Follicle Center Lymphoma

Symptoms & Phenotypes for Primary Cutaneous Follicle Center Lymphoma

Drugs & Therapeutics for Primary Cutaneous Follicle Center Lymphoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1 Multidose Study to Evaluate the Safety and Tolerability of XmAb13676 in Patients With CD20-Expressing Hematologic Malignancies Recruiting NCT02924402 Phase 1

Search NIH Clinical Center for Primary Cutaneous Follicle Center Lymphoma

Genetic Tests for Primary Cutaneous Follicle Center Lymphoma

Anatomical Context for Primary Cutaneous Follicle Center Lymphoma

MalaCards organs/tissues related to Primary Cutaneous Follicle Center Lymphoma:

40
B Cells, Skin, T Cells, Lymph Node, Brain, Breast

Publications for Primary Cutaneous Follicle Center Lymphoma

Articles related to Primary Cutaneous Follicle Center Lymphoma:

(show top 50) (show all 122)
# Title Authors PMID Year
1
De-escalated radiotherapy for indolent primary cutaneous B-cell lymphoma. 61
31758232 2020
2
Primary Cutaneous Follicle Center Lymphoma in a 16-Year-old boy With Crohn Disease Exposed to Infliximab and Methotrexate. 61
31978035 2020
3
Navigating the cutaneous B-cell lymphomas: avoiding the rocky shoals. 61
31653979 2020
4
Prevalence of atopy and staphylococcal superantigen-specific immunoglobulin E (IgE) antibodies and total serum IgE in primary cutaneous T- and B-cell lymphoma. 61
31587349 2019
5
Unusual Clinical Presentation of a Primary Cutaneous Follicle Center Lymphoma on the Scalp of a Middle-Aged Female: Case Report and Review of the Literature. 61
31799268 2019
6
Primary Cutaneous Follicle Center Lymphoma in a 16-Year-Old Male with Crohn's Disease Exposed to Infliximab and Methotrexate. 61
31789777 2019
7
T-Cell-Rich Recurrence of Primary Cutaneous Follicle Center Lymphoma After Systemic Rituximab: A Diagnostic Pitfall. 61
31592859 2019
8
Acquired N-Linked Glycosylation Motifs in B-Cell Receptors of Primary Cutaneous B-Cell Lymphoma and the Normal B-Cell Repertoire. 61
31042459 2019
9
Macular presentation of primary cutaneous follicle center lymphoma with an intermittent clinical course. 61
31389373 2019
10
Cutaneous composite small lymphocytic lymphoma and primary cutaneous follicle center lymphoma. 61
31439617 2019
11
Primary cutaneous B-cell lymphoma: narrative review of the literature. 61
29144099 2019
12
A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes. 61
31462626 2019
13
Primary cutaneous large B-cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases. 61
30715765 2019
14
Primary cutaneous vs secondary cutaneous follicular lymphomas: A comparative study focused on BCL2, CD10, and t(14;18) expression. 61
30511443 2019
15
Primary Cutaneous Follicle Center Lymphoma of the Eyelid: A Case Report and Review of the Literature in Light of Recent Changes to the WHO Classification of Lymphoid Neoplasms. 61
30976595 2019
16
Cutaneous B-Cell Lymphoma. 61
30497672 2019
17
Radiation therapy in indolent primary cutaneous B cell lymphoma: a single institute experience. 61
30094511 2018
18
Primary Cutaneous Follicle Center Lymphoma. 61
30407851 2018
19
Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management. 61
30039522 2018
20
High Incidence and Clinical Significance of MYC Rearrangements in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. 61
30113335 2018
21
Primary Cutaneous Follicle Center Lymphoma Clear Cell Variant: Expanding the Spectrum of Cutaneous Clear Cell Neoplasms. 61
29877892 2018
22
Concomitant 1p36 deletion and TNFRSF14 mutations in primary cutaneous follicle center lymphoma frequently expressing high levels of EZH2 protein. 61
29858685 2018
23
Outcomes of radiation therapy of indolent cutaneous B-cell lymphomas and literature review. 61
29578630 2018
24
Helicobacter pylori eradication may successfully treat primary cutaneous follicle center lymphoma. 61
29897650 2018
25
Primary cutaneous B-cell lymphoma: A single-center 5-year experience. 61
30604723 2018
26
Primary cutaneous B-cell lymphomas- clinical and histopathologic features, differential diagnosis, and treatment. 61
29719020 2018
27
Primary cutaneous follicle center lymphoma mimicking folliculitis. 61
29529119 2018
28
Primary cutaneous follicle center lymphoma. 61
29166511 2017
29
Primary Cutaneous B-cell Lymphomas. 61
28802500 2017
30
Primary cutaneous large B-cell lymphoma of scalp: Case report of a rare variant. 61
28631652 2017
31
An Aggressive Primary Cutaneous Follicle Center Lymphoma With c-MYC Translocation and CDKN2A (9p21) Deletion: A Case Report and Review of the Literature. 61
27759694 2017
32
Intralesional anti-CD20 antibody for low-grade primary cutaneous B-cell lymphoma: Adverse reactions correlate with favorable clinical outcome. 61
28177583 2017
33
Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma. 61
28065463 2017
34
Cutaneous B-cell lymphomas - pathogenesis, diagnostic workup, and therapy. 61
27992127 2016
35
B-Zell-Lymphome der Haut - Pathogenese, Diagnostik und Therapie. 61
27992139 2016
36
Atypical clinical presentation of primary and secondary cutaneous follicle center lymphoma (FCL) on the head characterized by macular lesions. 61
27380773 2016
37
Cutaneous B-cell lymphomas: 2016 update on diagnosis, risk-stratification, and management. 61
27650702 2016
38
TOX expression in cutaneous B-cell lymphomas. 61
27180090 2016
39
Spindle B-cell lymphoma: a rare variant of follicle center lymphoma. 61
26955785 2016
40
Primary cutaneous follicle center lymphoma in a patient with WHIM syndrome. 61
25571909 2016
41
Primary Cutaneous Follicle Center Lymphomas Expressing BCL2 Protein Frequently Harbor BCL2 Gene Break and May Present 1p36 Deletion: A Study of 20 Cases. 61
26658664 2016
42
Primary cutaneous lymphoma in southern Brazil: a 12-year single-center experience. 61
26496535 2015
43
Primary cutaneous follicle center lymphoma associated with an extracutaneous dissemination: a cytogenetic finding of potential prognostic value. 61
26486746 2015
44
Primary Cutaneous B-Cell Lymphoma: Management and Patterns of Recurrence at the Multimodality Cutaneous Lymphoma Clinic of The Ohio State University. 61
26306900 2015
45
Frequency of primary cutaneous lymphoma variants in Austria: retrospective data from a dermatology referral centre between 2006 and 2013. 61
25600184 2015
46
Epstein-Barr virus-positive primary cutaneous follicle centre lymphoma; an age-related phenomenon? 61
25957860 2015
47
The High Expression of the microRNA 17-92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression. 61
25634356 2015
48
Primary cutaneous follicle center lymphoma simulating basal-cell carcinoma on the nasal ala. 61
26312690 2015
49
Diagnostic and prognostic value of BCL2 rearrangement in 53 patients with follicular lymphoma presenting as primary skin lesions. 61
25696794 2015
50
Clinical features and treatment outcomes of primary cutaneous B-cell lymphoma: a single-center analysis in South Korea. 61
25552248 2015

Variations for Primary Cutaneous Follicle Center Lymphoma

Cosmic variations for Primary Cutaneous Follicle Center Lymphoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM95255195 haematopoietic and lymphoid tissue,head neck,lymphoid neoplasm,follicular lymphoma c.62C>A p.S21* 23:101375223-101375223 0

Expression for Primary Cutaneous Follicle Center Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous Follicle Center Lymphoma.

Pathways for Primary Cutaneous Follicle Center Lymphoma

GO Terms for Primary Cutaneous Follicle Center Lymphoma

Sources for Primary Cutaneous Follicle Center Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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