MCID: PRM339
MIFTS: 32

Primary Glomerular Disease

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Primary Glomerular Disease

MalaCards integrated aliases for Primary Glomerular Disease:

Name: Primary Glomerular Disease 59

Classifications:

Orphanet: 59  
Rare renal diseases


External Ids:

Orphanet 59 ORPHA102373

Summaries for Primary Glomerular Disease

MalaCards based summary : Primary Glomerular Disease is related to glomerulonephritis and iga glomerulonephritis. An important gene associated with Primary Glomerular Disease is ALB (Albumin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. The drugs Losartan and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and prostate, and related phenotypes are neoplasm and renal/urinary system

Related Diseases for Primary Glomerular Disease

Diseases in the Glomerular Disease family:

Secondary Glomerular Disease Primary Glomerular Disease

Diseases related to Primary Glomerular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 30.9 TGFB1 ALB
2 iga glomerulonephritis 30.8 TGFB1 ALB
3 membranous nephropathy 30.7 TGFB1 ALB
4 end stage renal failure 30.3 TGFB1 ALB
5 focal segmental glomerulosclerosis 29.8 TGFB1 ALB
6 kidney disease 29.0 TGFB1 SERPINE1 ALB
7 glomerular disease 10.6
8 nephrotic syndrome 10.4
9 lipoid nephrosis 10.4
10 membranoproliferative glomerulonephritis 10.3
11 proliferative glomerulonephritis 10.3
12 mesangial proliferative glomerulonephritis 10.2
13 kidney hypertrophy 10.2 TGFB1 ALB
14 ascending cholangitis 10.1 TGFB1 ALB
15 transient arthritis 10.1 TGFB1 ALB
16 urinary tract obstruction 10.1 TGFB1 ALB
17 hydronephrosis 10.1 TGFB1 ALB
18 obstructive nephropathy 10.1 TGFB1 ALB
19 biliary atresia 10.1 TGFB1 ALB
20 crescentic glomerulonephritis 10.1
21 peyronie's disease 10.0 TGFB1 DCN
22 dupuytren contracture 10.0 TGFB1 DCN
23 nephrogenic systemic fibrosis 10.0 TGFB1 DCN
24 localized scleroderma 10.0 TGFB1 DCN
25 crouzon syndrome 10.0 TGFB1 DCN
26 systemic lupus erythematosus 10.0
27 chronic kidney disease 10.0
28 gingival overgrowth 9.9 TGFB1 DCN
29 urinary system disease 9.9 TGFB1 ALB
30 alport syndrome 9.9
31 nephrosclerosis 9.9
32 rapidly progressive glomerulonephritis 9.9
33 lupus erythematosus 9.9
34 dense deposit disease 9.9
35 mesangioproliferative glomerulopathy 9.9
36 respiratory system disease 9.9 TGFB1 ALB
37 hepatic vascular disease 9.9 SERPINE1 ALB
38 chondromyxoid fibroma 9.8 TGFB1 SERPINE1
39 paranasal sinus disease 9.8 TGFB1 SERPINE1
40 vein disease 9.8 SERPINE1 ALB
41 intermittent claudication 9.8 SERPINE1 ALB
42 coronary stenosis 9.8 SERPINE1 ALB
43 idiopathic interstitial pneumonia 9.8 TGFB1 SERPINE1
44 pulmonary embolism 9.8 SERPINE1 ALB
45 iga nephropathy 1 9.8
46 wilms tumor 5 9.8
47 hepatitis c virus 9.8
48 thrombosis 9.8
49 vascular disease 9.8
50 hepatitis c 9.8

Graphical network of the top 20 diseases related to Primary Glomerular Disease:



Diseases related to Primary Glomerular Disease

Symptoms & Phenotypes for Primary Glomerular Disease

MGI Mouse Phenotypes related to Primary Glomerular Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 ALB DCN SERPINE1 TGFB1
2 renal/urinary system MP:0005367 8.92 ALB DCN SERPINE1 TGFB1

Drugs & Therapeutics for Primary Glomerular Disease

Drugs for Primary Glomerular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4 114798-26-4 3961
2
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
3 Antihypertensive Agents Phase 4
4 Immunoglobulin A Phase 4
5 Angiotensinogen Phase 4
6 Angiotensin II Type 1 Receptor Blockers Phase 4
7 Giapreza Phase 4
8 Cassava Phase 4
9 Angiotensin Receptor Antagonists Phase 4
10 Anti-Arrhythmia Agents Phase 4
11
Epoprostenol Approved Phase 2, Phase 3 35121-78-9, 61849-14-7 5282411 5280427
12
Mycophenolic acid Approved Phase 3 24280-93-1 446541
13
Azathioprine Approved Phase 3 446-86-6 2265
14 Tezosentan Investigational Phase 2, Phase 3 180384-57-0
15 Beraprost Investigational Phase 2, Phase 3 88430-50-6
16 Platelet Aggregation Inhibitors Phase 2, Phase 3
17 Vasodilator Agents Phase 2, Phase 3
18 Immunologic Factors Phase 3
19 Anti-Bacterial Agents Phase 3
20 Antitubercular Agents Phase 3
21 Immunosuppressive Agents Phase 3
22 Anti-Infective Agents Phase 3
23 Antibiotics, Antitubercular Phase 3
24 Antimetabolites, Antineoplastic Phase 3
25 Antimetabolites Phase 3
26 Antirheumatic Agents Phase 3
27
Vitamin D3 Approved, Nutraceutical 67-97-0 6221 5280795
28
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
29
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
30
Calcium Approved, Nutraceutical 7440-70-2 271
31 Micronutrients
32 Trace Elements
33 Hormones
34 Vitamins
35 Nutrients
36 Immunoglobulins
37 Vitamin D2
38 Antibodies
39 Ergocalciferols
40 Calciferol
41 Calcium, Dietary
42 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy: a Multicentre, Double-blind, Double-dummy, Randomized Controlled Trial Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
2 TRK-100STP PhaseIIb/III Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
3 A Randomized, Multicenter Study to Assess the Efficacy on Diseases Activity of Enteric-coated Mycophenolate Sodium Versus Continuation of Azathioprine in Patients With Systemic Lupus Erythematosus on Azathioprine Maintenance Therapy. Terminated NCT00504244 Phase 3 switch to Myfortic;continuation of azathioprine
4 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo
5 Histological and Clinical Biomarkers to Predict the Progression of IgA Nephropathy Completed NCT02529722
6 Pilot Study: Efficacy and Safety of Vitamin D Supplementation in Glomerular Disease Completed NCT01835639

Search NIH Clinical Center for Primary Glomerular Disease

Genetic Tests for Primary Glomerular Disease

Anatomical Context for Primary Glomerular Disease

MalaCards organs/tissues related to Primary Glomerular Disease:

41
Kidney, Bone, Prostate, B Cells

Publications for Primary Glomerular Disease

Articles related to Primary Glomerular Disease:

(show top 50) (show all 249)
# Title Authors PMID Year
1
Recent advances in risk prediction, therapeutics and pathogenesis of IgA nephropathy. 38
31142099 2019
2
Clinical outcomes and effects of treatment in older patients with idiopathic membranous nephropathy. 38
31408925 2019
3
Gene polymorphism and risk of idiopathic membranous nephropathy. 38
31075233 2019
4
Obesity is not associated with progression to end stage renal disease in patients with biopsy-proven glomerular diseases. 38
31266462 2019
5
Structural prediction of antibody-APRIL complexes by computational docking constrained by antigen saturation mutagenesis library data. 38
30761651 2019
6
Effects of Sustained-Release Beraprost in Patients With Primary Glomerular Disease or Nephrosclerosis: CASSIOPEIR Study Results. 38
31119846 2019
7
Urine markers of renal tubular injury in idiopathic membranous nephropathy: A cross sectional study. 38
30684459 2019
8
High serum IgA/C3 ratio better predicts a diagnosis of IgA nephropathy among primary glomerular nephropathy patients with proteinuria ≤ 1 g/d: an observational cross-sectional study. 38
31039758 2019
9
LncRNAs expression in adriamycin-induced rats reveals the potential role of LncRNAs contributing to chronic glomerulonephritis pathogenesis. 38
30458286 2019
10
Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction. 38
31334040 2019
11
Immunoglobulin A Nephropathy. Recurrence After Renal Transplantation. 38
31275309 2019
12
Serum immunoglobulin G provides early risk prediction in immunoglobulin A nephropathy. 38
30415190 2019
13
Changing Protein Permeability with Nephron Loss: Evidence for a Human Remnant Nephron Effect. 38
31269482 2019
14
Pattern of glomerular disease and clinicopathological correlation: A single-center study from Eastern Nepal. 38
30588974 2018
15
Clinicopathological features of pediatric renal biopsies in the plateau regions of China. 38
30027800 2018
16
Angiopoietin-2: A Potential Mediator of the Glycocalyx Injury in Adult Nephrotic Patients. 38
30384404 2018
17
Successful treatment with rituximab of immunotactoid glomerulopathy exhibiting nephrotic syndrome
. 38
30049299 2018
18
Epidemiology of IgA Nephropathy: A Global Perspective. 38
30177015 2018
19
U6 can be used as a housekeeping gene for urinary sediment miRNA studies of IgA nephropathy. 38
30022109 2018
20
The Spectrum of Biopsy-Proven Glomerular Diseases among Children in China: A National, Cross-Sectional Survey. 38
29915132 2018
21
The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China. 38
29998121 2018
22
First-year GFR slope and long-term renal outcome in IgA nephropathy. 38
29660832 2018
23
Primary IgA nephropathy in the Kashmiri population. 38
29970746 2018
24
Fibrillary glomerulonephritis in an HIV patient without concurrent hepatitis C infection: Case report and review of the literature
. 38
29578397 2018
25
Characteristics of Patients Initializing Peritoneal Dialysis Treatment From 2007 to 2014: Analysis From Henan Peritoneal Dialysis Registry data. 38
29891748 2018
26
Liddle's-like syndrome associated with nephrotic syndrome secondary to membranous nephropathy: the first case report. 38
29792170 2018
27
Fibrillary Glomerulonephritis in a Patient with Sjogren's Syndrome. 38
29922524 2018
28
Evaluation of serum soluble urokinase plasminogen activator receptor as a marker for steroid-responsiveness in children with primary nephrotic syndrome. 38
29657195 2018
29
Potential role of lncRNAs in contributing to pathogenesis of chronic glomerulonephritis based on microarray data. 38
29199037 2018
30
Molecular Mechanisms of Proteinuria in Focal Segmental Glomerulosclerosis. 38
29713631 2018
31
DnaJ Heat Shock Protein Family B Member 9 Is a Novel Biomarker for Fibrillary GN. 38
29097623 2018
32
Distribution of glomerular diseases in Taiwan: preliminary report of National Renal Biopsy Registry-publication on behalf of Taiwan Society of Nephrology. 38
29320993 2018
33
Fibrillary Glomerulonephritis in Primary Sjogren's Syndrome: A Rare Cause of Renal Failure. 38
29196420 2017
34
Recurrent glomerular disease after kidney transplantation. 38
28832357 2017
35
ANCA-positive IgA nephropathy without necrotising or crescentic glomerulonephritis: a clinical conundrum. 38
29170179 2017
36
Symptomatic fracture risk in the renal replacement therapy population. 38
27257273 2017
37
Nephrotic syndrome in pregnancy poses risks with both maternal and fetal complications. 38
28233609 2017
38
Clinicopathological Analysis of Glomerular Disease of Adult Onset Nephrotic Syndrome in an Indian Cohort- A Retrospective Study. 38
28658768 2017
39
Abelmoschus manihot - a traditional Chinese medicine versus losartan potassium for treating IgA nephropathy: study protocol for a randomized controlled trial. 38
28395659 2017
40
Fibrillary glomerulonephritis presenting as crescentic glomerulonephritis. 38
28356674 2017
41
Analysis of patients with end-stage renal disease on dialysis in Tabuk City, Saudi Arabia: A single-center, three-year retrospective study. 38
28352019 2017
42
Increasing prevalence of membranous nephropathy in patients with primary glomerular diseases: A cross-sectional study in China. 38
26854278 2017
43
Pregnancy Outcomes in Patients with Glomerular Disease Attending a Single Academic Center in North Carolina. 38
28445873 2017
44
Is there a role for immunosuppression in immunoglobulin A nephropathy? 38
28391341 2017
45
Unwinding focal segmental glomerulosclerosis. 38
28491286 2017
46
Tubular urinary indexes reliably distinguish between primary tubulointerstitial and primary glomerular diseases in patients referred for kidney biopsy. 38
28601117 2017
47
The effects of Qi Teng Xiao Zhuo granules, traditional Chinese medicine, on the expression of genes in chronic glomerulonephritis rats. 38
27497640 2016
48
Twenty-eight-year review of childhood renal diseases from renal biopsy data: A single centre in China. 38
26698187 2016
49
Urinary fibrinogen and renal tubulointerstitial fibrinogen deposition: Discriminating between primary FSGS and minimal change disease. 38
27539323 2016
50
Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity. 38
27127888 2016

Variations for Primary Glomerular Disease

Expression for Primary Glomerular Disease

Search GEO for disease gene expression data for Primary Glomerular Disease.

Pathways for Primary Glomerular Disease

Pathways related to Primary Glomerular Disease according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 TGFB1 SERPINE1 ALB
2
Show member pathways
11.84 TGFB1 SERPINE1
3 11.83 TGFB1 DCN
4
Show member pathways
11.79 TGFB1 SERPINE1 DCN
5 11.77 TGFB1 SERPINE1
6 11.7 TGFB1 SERPINE1
7 11.66 TGFB1 SERPINE1
8 11.58 TGFB1 ALB
9 11.55 TGFB1 SERPINE1
10 11.43 TGFB1 SERPINE1
11 11.37 TGFB1 SERPINE1
12 11.29 TGFB1 DCN
13 11.11 TGFB1 SERPINE1
14 10.92 TGFB1 SERPINE1
15 10.56 TGFB1 SERPINE1 DCN

GO Terms for Primary Glomerular Disease

Cellular components related to Primary Glomerular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TGFB1 SERPINE1 DCN ALB
2 extracellular space GO:0005615 9.46 TGFB1 SERPINE1 DCN ALB
3 blood microparticle GO:0072562 9.37 TGFB1 ALB
4 Golgi lumen GO:0005796 9.32 TGFB1 DCN
5 collagen-containing extracellular matrix GO:0062023 9.13 TGFB1 SERPINE1 DCN
6 platelet alpha granule lumen GO:0031093 8.8 TGFB1 SERPINE1 ALB

Biological processes related to Primary Glomerular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.43 TGFB1 SERPINE1 DCN
2 extracellular matrix organization GO:0030198 9.32 SERPINE1 DCN
3 aging GO:0007568 9.16 TGFB1 DCN
4 wound healing GO:0042060 8.96 TGFB1 DCN
5 platelet degranulation GO:0002576 8.8 TGFB1 SERPINE1 ALB

Molecular functions related to Primary Glomerular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 8.62 TGFB1 DCN

Sources for Primary Glomerular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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