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MCID: PRM205
MIFTS: 29

Primary Hepatic Neuroendocrine Carcinoma

Categories: Cancer diseases, Endocrine diseases, Liver diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards integrated aliases for Primary Hepatic Neuroendocrine Carcinoma:

Name: Primary Hepatic Neuroendocrine Carcinoma 59
Liver Neuroendocrine Carcinoma 72

Characteristics:

Orphanet epidemiological data:

59
primary hepatic neuroendocrine carcinoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: adult,elderly;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Liver diseases Endocrine diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare hepatic diseases
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 34 C22.7
Orphanet 59 ORPHA100085
UMLS 72 C3273031
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Summaries for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards based summary : Primary Hepatic Neuroendocrine Carcinoma, also known as liver neuroendocrine carcinoma, is related to neuroendocrine tumor and carcinoid syndrome. An important gene associated with Primary Hepatic Neuroendocrine Carcinoma is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, brain and heart, and related phenotypes are neoplasm of the liver and hepatomegaly

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Related Diseases for Primary Hepatic Neuroendocrine Carcinoma

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Diseases related to Primary Hepatic Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 30.3 SYP CHGA
2 carcinoid syndrome 29.8 SYP CHGA
3 leiomyosarcoma 29.6 VIM S100B
4 neuroendocrine carcinoma 10.6
5 hepatic tuberculosis 10.3 GPT ALPP
6 clear cell meningioma 10.3 VIM CHGA
7 fascioliasis 10.3 GPT ALPP
8 syndrome of inappropriate antidiuretic hormone 10.3 VIM CHGA
9 endodermal sinus tumor 10.3 VIM CHGA
10 choledocholithiasis 10.3 GPT ALPP
11 dermoid cyst 10.2 VIM CHGA
12 epithelioid malignant peripheral nerve sheath tumor 10.2 S100B CHGA
13 hydromyelia 10.2 VIM S100B
14 bednar tumor 10.2 VIM S100B
15 obstructive jaundice 10.2 GPT ALPP
16 malignant peripheral nerve sheath tumor 10.2 VIM S100B
17 syringocystadenoma papilliferum 10.2 VIM S100B
18 fibrous meningioma 10.2 VIM S100B
19 ossifying fibromyxoid tumor 10.2 VIM S100B
20 eccrine porocarcinoma 10.2 VIM S100B
21 monophasic synovial sarcoma 10.1 VIM S100B
22 myxopapillary ependymoma 10.1 VIM S100B
23 syringoma 10.1 VIM S100B
24 juvenile xanthogranuloma 10.1 VIM S100B
25 pleomorphic liposarcoma 10.1 VIM S100B
26 cutaneous fibrous histiocytoma 10.1 VIM S100B
27 fibrous histiocytoma 10.1 VIM S100B
28 amelanotic melanoma 10.1 VIM S100B
29 perineurioma 10.1 VIM S100B
30 odontogenic myxoma 10.1 VIM S100B
31 spindle cell sarcoma 10.1 VIM S100B
32 granular cell tumor 10.1 VIM S100B
33 embryonal sarcoma 10.1 VIM S100B
34 dendritic cell tumor 10.1 VIM S100B
35 hepatocellular carcinoma 10.1
36 polymorphous low-grade adenocarcinoma 10.1 VIM S100B
37 hidradenocarcinoma 10.1 VIM S100B
38 ureter small cell carcinoma 10.0 SYP CHGA
39 small cell carcinoma 10.0 SYP CHGA
40 esophageal neuroendocrine tumor 10.0 SYP CHGA
41 urinary bladder small cell neuroendocrine carcinoma 10.0 SYP CHGA
42 ovarian large-cell neuroendocrine carcinoma 10.0 SYP CHGA
43 auditory system cancer 10.0 SYP CHGA
44 acinar cell cystadenocarcinoma 10.0 SYP CHGA
45 cellular ependymoma 10.0 SYP CHGA
46 peritoneal serous adenocarcinoma 10.0 SYP CHGA
47 small cell carcinoma of the bladder 10.0 SYP CHGA
48 hemangiopericytoma, malignant 10.0 VIM S100B
49 cystadenoma 10.0 SYP CHGA
50 gastrointestinal neuroendocrine tumor 10.0 SYP CHGA

Graphical network of the top 20 diseases related to Primary Hepatic Neuroendocrine Carcinoma:



Diseases related to Primary Hepatic Neuroendocrine Carcinoma
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Symptoms & Phenotypes for Primary Hepatic Neuroendocrine Carcinoma

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Human phenotypes related to Primary Hepatic Neuroendocrine Carcinoma:

59 32 (show all 38)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neoplasm of the liver 59 32 obligate (100%) Obligate (100%) HP:0002896
2 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
3 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
4 ascites 59 32 frequent (33%) Frequent (79-30%) HP:0001541
5 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
6 elevated hepatic transaminase 59 32 frequent (33%) Frequent (79-30%) HP:0002910
7 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
8 chronic fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012432
9 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
10 episodic abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002574
11 abdominal distention 59 32 frequent (33%) Frequent (79-30%) HP:0003270
12 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
13 chronic noninfectious lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002730
14 hepatic cysts 59 32 occasional (7.5%) Occasional (29-5%) HP:0001407
15 carcinoid tumor 59 32 occasional (7.5%) Occasional (29-5%) HP:0100570
16 facial telangiectasia 59 32 occasional (7.5%) Occasional (29-5%) HP:0007380
17 increased serum serotonin 59 32 occasional (7.5%) Occasional (29-5%) HP:0003144
18 palpitations 59 32 occasional (7.5%) Occasional (29-5%) HP:0001962
19 night sweats 59 32 occasional (7.5%) Occasional (29-5%) HP:0030166
20 heart murmur 59 32 occasional (7.5%) Occasional (29-5%) HP:0030148
21 hepatic encephalopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002480
22 right ventricular failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001708
23 erythematous plaque 59 32 occasional (7.5%) Occasional (29-5%) HP:0025474
24 bronchospasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0025428
25 ptosis 59 32 very rare (1%) Very rare (<4-1%) HP:0000508
26 neoplasm of the lung 59 32 very rare (1%) Very rare (<4-1%) HP:0100526
27 reduced visual acuity 59 32 very rare (1%) Very rare (<4-1%) HP:0007663
28 neoplasm of the eye 59 32 very rare (1%) Very rare (<4-1%) HP:0100012
29 elevated alkaline phosphatase of hepatic origin 59 32 very rare (1%) Very rare (<4-1%) HP:0010638
30 abnormal brain fdg positron emission tomography 59 32 very rare (1%) Very rare (<4-1%) HP:0012658
31 biliary tract obstruction 59 32 very rare (1%) Very rare (<4-1%) HP:0005230
32 intermittent jaundice 59 32 very rare (1%) Very rare (<4-1%) HP:0001046
33 intrahepatic cholestasis with episodic jaundice 59 32 very rare (1%) Very rare (<4-1%) HP:0006575
34 elevated gamma-glutamyltransferase activity 59 32 very rare (1%) Very rare (<4-1%) HP:0030948
35 neuroendocrine neoplasm 59 Obligate (100%)
36 neoplasm of the nervous system 59 Very rare (<4-1%)
37 elevated alpha-fetoprotein 59 Excluded (0%)
38 elevated carcinoembryonic antigen level 59 Excluded (0%)
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Drugs & Therapeutics for Primary Hepatic Neuroendocrine Carcinoma

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Search Clinical Trials , NIH Clinical Center for Primary Hepatic Neuroendocrine Carcinoma

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Genetic Tests for Primary Hepatic Neuroendocrine Carcinoma

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Anatomical Context for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards organs/tissues related to Primary Hepatic Neuroendocrine Carcinoma:

41
Liver, Brain, Heart, Lung, Eye
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Publications for Primary Hepatic Neuroendocrine Carcinoma

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Articles related to Primary Hepatic Neuroendocrine Carcinoma:

(show all 39)
# Title Authors PMID Year
1
Primary hepatic neuroendocrine carcinoma with massive hepatomegaly in a young-old woman. 38
31429180 2019
2
Primary Hepatic Neuroendocrine Carcinoma Treated with Doxorubicin and Cyclophosphamide in a Dog. 38
30870605 2019
3
Primary hepatic neuroendocrine carcinoma: report of two cases and literature review. 38
29507528 2018
4
[A Case of Mixed Hepatocellular and Primary Hepatic Neuroendocrine Carcinomas with Remnant Liver Recurrence and Rapid Exacerbation]. 38
29394763 2017
5
Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report. 38
28647212 2017
6
Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. 38
28895097 2017
7
Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature. 38
27895410 2016
8
[A Case of Composite Hepatocellular Carcinoma and Neuroendocrine Carcinoma in a Patient with Liver Cirrhosis Caused by Chronic Hepatitis B]. 38
27554219 2016
9
Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review. 38
27384317 2016
10
Primary Hepatic Neuroendocrine Carcinoma: Case Reports and Review of the Literature. 38
26882787 2016
11
[Diagnosis and treatment of primary hepatic neuroendocrine carcinoma]. 38
26463150 2015
12
Hepatic primary neuroendocrine carcinoma: about a new case. 38
26161177 2015
13
Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. 38
26184027 2014
14
Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma. 38
25051214 2014
15
Imaging and pathological features of primary hepatic neuroendocrine carcinoma: An analysis of nine cases and review of the literature. 38
24944650 2014
16
Surgery for giant primary neuroendocrine carcinoma of the liver. 38
24146337 2014
17
Diagnosis and therapy of primary hepatic neuroendocrine carcinoma: clinical analysis of 10 cases. 38
24761861 2014
18
Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. 38
23942951 2013
19
Postoperative outcomes of primary hepatic neuroendocrine carcinomas: review article. 38
24575586 2013
20
Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat. 38
23738981 2013
21
Primary hepatic neuroendocrine carcinoma. 38
26155210 2013
22
Combined hepatocellular carcinoma and neuroendocrine carcinoma with sarcomatous change of the liver after transarterial chemoembolization. 38
23094854 2012
23
Clinical features and outcomes of primary hepatic neuroendocrine carcinomas. 38
22414232 2012
24
Neuroendocrine liver metastases: contributions of endoscopy and surgery to primary tumor search. 38
22416174 2012
25
Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. 38
22288038 2012
26
[Primary hepatic neuroendocrine carcinoma]. 38
22716014 2012
27
Primary hepatic neuroendocrine carcinoma with nonbacterial thrombotic endocarditis: a case report. 38
21329891 2011
28
[Case of primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy]. 38
21139365 2010
29
Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. 38
20133228 2010
30
Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case. 38
20107963 2010
31
Primary hepatic neuroendocrine carcinoma in a baboon (Papio sp.). 38
18715267 2009
32
Hyperammonemic encephalopathy in a patient with primary hepatic neuroendocrine carcinoma. 38
19031017 2009
33
Neuroendocrine carcinoma of the liver associated with dermatomyositis: autopsy case and review of the literature. 38
17096733 2006
34
[A case of primary neuroendocrine carcinoma of liver presenting with liver abscess]. 38
17060722 2006
35
Primary hepatic neuroendocrine carcinoma: an underdiagnosed entity. 38
16414542 2006
36
Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case. 38
12658390 2003
37
Primary neuroendocrine carcinoma of the liver: an autopsy case. 38
11844054 2001
38
Primary hepatic neuroendocrine carcinoma with multiple metastases: a case report. 38
8539446 1995
39
Primary hepatic neuroendocrine carcinoma in a child. Morphologic, immunocytochemical, and molecular biologic studies. 38
8453589 1993
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Variations for Primary Hepatic Neuroendocrine Carcinoma

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Expression for Primary Hepatic Neuroendocrine Carcinoma

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Search GEO for disease gene expression data for Primary Hepatic Neuroendocrine Carcinoma.
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Pathways for Primary Hepatic Neuroendocrine Carcinoma

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Pathways related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.7 VIM SYP S100B
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GO Terms for Primary Hepatic Neuroendocrine Carcinoma

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Biological processes related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 8.62 SYP S100B
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Sources for Primary Hepatic Neuroendocrine Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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