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MCID: PRM205
MIFTS: 34

Primary Hepatic Neuroendocrine Carcinoma

Categories: Cancer diseases, Endocrine diseases, Liver diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards integrated aliases for Primary Hepatic Neuroendocrine Carcinoma:

Name: Primary Hepatic Neuroendocrine Carcinoma 60
Liver Neuroendocrine Carcinoma 74

Characteristics:

Orphanet epidemiological data:

60
primary hepatic neuroendocrine carcinoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: adult,elderly;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Liver diseases Endocrine diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare hepatic diseases
Rare endocrine diseases


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Summaries for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards based summary : Primary Hepatic Neuroendocrine Carcinoma, also known as liver neuroendocrine carcinoma, is related to neuroendocrine carcinoma and hepatic tuberculosis. An important gene associated with Primary Hepatic Neuroendocrine Carcinoma is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, eye and kidney, and related phenotypes are neoplasm of the liver and hepatomegaly

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Related Diseases for Primary Hepatic Neuroendocrine Carcinoma

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Diseases related to Primary Hepatic Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 10.6
2 hepatic tuberculosis 10.3 ALPP GPT
3 fascioliasis 10.2 ALPP GPT
4 choledocholithiasis 10.2 ALPP GPT
5 clear cell meningioma 10.1 CHGA VIM
6 obstructive jaundice 10.1 ALPP GPT
7 syndrome of inappropriate antidiuretic hormone 10.1 CHGA VIM
8 endodermal sinus tumor 10.1 CHGA VIM
9 dermoid cyst 10.1 CHGA VIM
10 ureter small cell carcinoma 10.1 CHGA SYP
11 small cell carcinoma 10.1 CHGA SYP
12 esophageal neuroendocrine tumor 10.1 CHGA SYP
13 neuroendocrine tumor 10.1 CHGA SYP
14 urinary bladder small cell neuroendocrine carcinoma 10.1 CHGA SYP
15 ovarian large-cell neuroendocrine carcinoma 10.1 CHGA SYP
16 auditory system cancer 10.1 CHGA SYP
17 acinar cell cystadenocarcinoma 10.1 CHGA SYP
18 peritoneal serous adenocarcinoma 10.1 CHGA SYP
19 cellular ependymoma 10.1 CHGA SYP
20 small cell carcinoma of the bladder 10.1 CHGA SYP
21 gastrointestinal neuroendocrine tumor 10.1 CHGA SYP
22 papillary tumor of the pineal region 10.1 SYP VIM
23 cystadenoma 10.1 CHGA SYP
24 pulmonary large cell neuroendocrine carcinoma 10.1 CHGA SYP
25 large cell neuroendocrine carcinoma 10.1 CHGA SYP
26 gallbladder small cell carcinoma 10.1 CHGA SYP
27 atypical follicular adenoma 10.1 CHGA SYP
28 clear cell ependymoma 10.1 SYP VIM
29 olfactory groove meningioma 10.1 CHGA SYP
30 cauda equina neoplasm 10.1 CHGA SYP
31 pancreatic serous cystadenoma 10.1 CHGA SYP
32 conventional angiosarcoma 10.1 CHGA SYP
33 olfactory nerve neoplasm 10.1 CHGA SYP
34 astroblastoma 10.1 SYP VIM
35 autonomic nervous system benign neoplasm 10.1 CHGA SYP
36 melanotic neuroectodermal tumor 10.1 SYP VIM
37 nodular ganglioneuroblastoma 10.1 CHGA SYP
38 pulmonary sclerosing hemangioma 10.1 CHGA SYP
39 medulloepithelioma 10.1 SYP VIM
40 sclerosing hemangioma 10.1 CHGA SYP
41 hemangioma 10.1 CHGA SYP
42 gastric small cell carcinoma 10.1 CHGA SYP
43 pancreatoblastoma 10.1 CHGA SYP
44 subependymoma 10.1 CHGA SYP
45 desmoplastic small round cell tumor 10.1 SYP VIM
46 carcinoid tumors, intestinal 10.1 CHGA SYP
47 respiratory system benign neoplasm 10.1 CHGA SYP
48 perivascular epithelioid cell tumor 10.1 SYP VIM
49 anterior cranial fossa meningioma 10.1 CHGA SYP
50 gastric squamous cell carcinoma 10.1 CHGA SYP

Graphical network of the top 20 diseases related to Primary Hepatic Neuroendocrine Carcinoma:



Diseases related to Primary Hepatic Neuroendocrine Carcinoma
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Symptoms & Phenotypes for Primary Hepatic Neuroendocrine Carcinoma

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Human phenotypes related to Primary Hepatic Neuroendocrine Carcinoma:

60 33 (show all 38)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neoplasm of the liver 60 33 obligate (100%) Obligate (100%) HP:0002896
2 hepatomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002240
3 dyspnea 60 33 frequent (33%) Frequent (79-30%) HP:0002094
4 ascites 60 33 frequent (33%) Frequent (79-30%) HP:0001541
5 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
6 elevated hepatic transaminase 60 33 frequent (33%) Frequent (79-30%) HP:0002910
7 anorexia 60 33 frequent (33%) Frequent (79-30%) HP:0002039
8 chronic fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012432
9 diarrhea 60 33 frequent (33%) Frequent (79-30%) HP:0002014
10 episodic abdominal pain 60 33 frequent (33%) Frequent (79-30%) HP:0002574
11 abdominal distention 60 33 frequent (33%) Frequent (79-30%) HP:0003270
12 nausea 60 33 frequent (33%) Frequent (79-30%) HP:0002018
13 chronic noninfectious lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002730
14 hepatic cysts 60 33 occasional (7.5%) Occasional (29-5%) HP:0001407
15 carcinoid tumor 60 33 occasional (7.5%) Occasional (29-5%) HP:0100570
16 night sweats 60 33 occasional (7.5%) Occasional (29-5%) HP:0030166
17 palpitations 60 33 occasional (7.5%) Occasional (29-5%) HP:0001962
18 heart murmur 60 33 occasional (7.5%) Occasional (29-5%) HP:0030148
19 increased serum serotonin 60 33 occasional (7.5%) Occasional (29-5%) HP:0003144
20 right ventricular failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0001708
21 hepatic encephalopathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0002480
22 erythematous plaque 60 33 occasional (7.5%) Occasional (29-5%) HP:0025474
23 facial telangiectasia 60 33 occasional (7.5%) Occasional (29-5%) HP:0007380
24 bronchospasm 60 33 occasional (7.5%) Occasional (29-5%) HP:0025428
25 ptosis 60 33 very rare (1%) Very rare (<4-1%) HP:0000508
26 reduced visual acuity 60 33 very rare (1%) Very rare (<4-1%) HP:0007663
27 neoplasm of the eye 60 33 very rare (1%) Very rare (<4-1%) HP:0100012
28 neoplasm of the lung 60 33 very rare (1%) Very rare (<4-1%) HP:0100526
29 elevated alkaline phosphatase of hepatic origin 60 33 very rare (1%) Very rare (<4-1%) HP:0010638
30 abnormal brain fdg positron emission tomography 60 33 very rare (1%) Very rare (<4-1%) HP:0012658
31 biliary tract obstruction 60 33 very rare (1%) Very rare (<4-1%) HP:0005230
32 intermittent jaundice 60 33 very rare (1%) Very rare (<4-1%) HP:0001046
33 intrahepatic cholestasis with episodic jaundice 60 33 very rare (1%) Very rare (<4-1%) HP:0006575
34 elevated gamma-glutamyltransferase activity 60 33 very rare (1%) Very rare (<4-1%) HP:0030948
35 neuroendocrine neoplasm 60 Obligate (100%)
36 neoplasm of the nervous system 60 Very rare (<4-1%)
37 elevated alpha-fetoprotein 60 Excluded (0%)
38 elevated carcinoembryonic antigen level 60 Excluded (0%)
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Drugs & Therapeutics for Primary Hepatic Neuroendocrine Carcinoma

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Search Clinical Trials , NIH Clinical Center for Primary Hepatic Neuroendocrine Carcinoma

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Genetic Tests for Primary Hepatic Neuroendocrine Carcinoma

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Anatomical Context for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards organs/tissues related to Primary Hepatic Neuroendocrine Carcinoma:

42
Brain, Eye, Kidney, Ovary, Cervix, Pineal
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Publications for Primary Hepatic Neuroendocrine Carcinoma

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Articles related to Primary Hepatic Neuroendocrine Carcinoma:

(show all 21)
# Title Authors Year
1
Primary Hepatic Neuroendocrine Carcinoma Treated with Doxorubicin and Cyclophosphamide in a Dog. ( 30870605 )
2019
2
Primary hepatic neuroendocrine carcinoma: report of two cases and literature review. ( 29507528 )
2018
3
Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report. ( 28647212 )
2017
4
Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. ( 28895097 )
2017
5
Primary Hepatic Neuroendocrine Carcinoma: Case Reports and Review of the Literature. ( 26882787 )
2016
6
Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. ( 26184027 )
2014
7
Diagnosis and therapy of primary hepatic neuroendocrine carcinoma: clinical analysis of 10 cases. ( 24761861 )
2014
8
Imaging and pathological features of primary hepatic neuroendocrine carcinoma: An analysis of nine cases and review of the literature. ( 24944650 )
2014
9
Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma. ( 25051214 )
2014
10
Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat. ( 23738981 )
2013
11
Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. ( 23942951 )
2013
12
Primary hepatic neuroendocrine carcinoma. ( 26155210 )
2013
13
Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. ( 22288038 )
2012
14
Primary hepatic neuroendocrine carcinoma with nonbacterial thrombotic endocarditis: a case report. ( 21329891 )
2011
15
Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. ( 20133228 )
2010
16
Hyperammonemic encephalopathy in a patient with primary hepatic neuroendocrine carcinoma. ( 19031017 )
2009
17
Primary hepatic neuroendocrine carcinoma in a baboon (Papio sp.). ( 18715267 )
2009
18
Primary hepatic neuroendocrine carcinoma: an underdiagnosed entity. ( 16414542 )
2006
19
Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case. ( 12658390 )
2003
20
Primary hepatic neuroendocrine carcinoma with multiple metastases: a case report. ( 8539446 )
1995
21
Primary hepatic neuroendocrine carcinoma in a child. Morphologic, immunocytochemical, and molecular biologic studies. ( 8453589 )
1993
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Variations for Primary Hepatic Neuroendocrine Carcinoma

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Expression for Primary Hepatic Neuroendocrine Carcinoma

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Search GEO for disease gene expression data for Primary Hepatic Neuroendocrine Carcinoma.
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Pathways for Primary Hepatic Neuroendocrine Carcinoma

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Pathways related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.7 S100B SYP VIM
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GO Terms for Primary Hepatic Neuroendocrine Carcinoma

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Biological processes related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 8.62 S100B SYP
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Sources for Primary Hepatic Neuroendocrine Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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