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MCID: PRM205
MIFTS: 30

Primary Hepatic Neuroendocrine Carcinoma

Categories: Cancer diseases, Endocrine diseases, Liver diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards integrated aliases for Primary Hepatic Neuroendocrine Carcinoma:

Name: Primary Hepatic Neuroendocrine Carcinoma 58
Liver Neuroendocrine Carcinoma 71

Characteristics:

Orphanet epidemiological data:

58
primary hepatic neuroendocrine carcinoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: adult,elderly;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Liver diseases Endocrine diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare hepatic diseases
Rare endocrine diseases


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Summaries for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards based summary : Primary Hepatic Neuroendocrine Carcinoma, also known as liver neuroendocrine carcinoma, is related to neuroendocrine carcinoma and carcinoid syndrome. An important gene associated with Primary Hepatic Neuroendocrine Carcinoma is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, eye and brain, and related phenotypes are neoplasm of the liver and hepatomegaly

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Related Diseases for Primary Hepatic Neuroendocrine Carcinoma

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Diseases related to Primary Hepatic Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 30.6 SYP S100B CHGA
2 carcinoid syndrome 30.2 SYP CHGA
3 thyroid gland medullary carcinoma 29.9 SYP CHGA
4 neuroendocrine tumor 10.2
5 parenteral nutrition-associated cholestasis 10.2 GPT ALPP
6 hepatocellular carcinoma 10.2
7 cholangiocarcinoma 10.2
8 intrahepatic cholangiocarcinoma 10.2
9 ewing sarcoma of bone 10.1 VIM CHGA
10 parachordoma 10.1 VIM CHGA
11 large intestine lipoma 10.1 GPT CHGA
12 liver leiomyosarcoma 10.1 GPT CHGA
13 lipoma of colon 10.1 GPT CHGA
14 hepatic tuberculosis 10.1 GPT ALPP
15 choledocholithiasis 10.1 GPT ALPP
16 fascioliasis 10.1 GPT ALPP
17 intrahepatic bile duct adenoma 10.1 GPT CHGA
18 sex cord-gonadal stromal tumor 10.1 VIM ALPP
19 epithelioid malignant peripheral nerve sheath tumor 10.1 S100B CHGA
20 hydromyelia 10.1 VIM S100B
21 bednar tumor 10.1 VIM S100B
22 eccrine porocarcinoma 10.1 VIM S100B
23 obstructive jaundice 10.0 GPT ALPP
24 cutaneous leiomyosarcoma 10.0 VIM S100B
25 odontogenic myxoma 10.0 VIM S100B
26 embryonal sarcoma 10.0 VIM S100B
27 ossifying fibromyxoid tumor 10.0 VIM S100B
28 polymorphous low-grade adenocarcinoma 10.0 VIM S100B
29 parathyroid adenoma 10.0 CHGA ALPP
30 dendritic cell tumor 10.0 VIM S100B
31 fibrous meningioma 10.0 VIM S100B
32 spiradenoma 10.0 VIM S100B
33 optic nerve glioma 10.0 VIM S100B
34 monophasic synovial sarcoma 10.0 VIM S100B
35 syringoma 10.0 VIM S100B
36 thyroid carcinoma, familial medullary 10.0
37 carbonic anhydrase va deficiency, hyperammonemia due to 10.0
38 exanthem 10.0
39 nonbacterial thrombotic endocarditis 10.0
40 endocarditis 10.0
41 keratosis 10.0
42 leiomyosarcoma 10.0
43 liver disease 10.0
44 bile duct cancer 10.0
45 liver cirrhosis 10.0
46 exophthalmos 10.0
47 plasma cell leukemia 10.0
48 glucagonoma 10.0
49 encephalopathy 10.0
50 rare tumor 10.0

Graphical network of the top 20 diseases related to Primary Hepatic Neuroendocrine Carcinoma:



Diseases related to Primary Hepatic Neuroendocrine Carcinoma
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Symptoms & Phenotypes for Primary Hepatic Neuroendocrine Carcinoma

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Human phenotypes related to Primary Hepatic Neuroendocrine Carcinoma:

58 31 (show all 39)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neoplasm of the liver 58 31 obligate (100%) Obligate (100%) HP:0002896
2 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
3 ascites 58 31 frequent (33%) Frequent (79-30%) HP:0001541
4 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
5 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
6 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
7 chronic fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012432
8 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
9 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
10 abdominal distention 58 31 frequent (33%) Frequent (79-30%) HP:0003270
11 episodic abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002574
12 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
13 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
14 facial telangiectasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0007380
15 night sweats 58 31 occasional (7.5%) Occasional (29-5%) HP:0030166
16 heart murmur 58 31 occasional (7.5%) Occasional (29-5%) HP:0030148
17 palpitations 58 31 occasional (7.5%) Occasional (29-5%) HP:0001962
18 carcinoid tumor 58 31 occasional (7.5%) Occasional (29-5%) HP:0100570
19 hepatic encephalopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002480
20 right ventricular failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001708
21 hepatic cysts 58 31 occasional (7.5%) Occasional (29-5%) HP:0001407
22 increased serum serotonin 58 31 occasional (7.5%) Occasional (29-5%) HP:0003144
23 bronchospasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0025428
24 erythematous plaque 58 31 occasional (7.5%) Occasional (29-5%) HP:0025474
25 ptosis 58 31 very rare (1%) Very rare (<4-1%) HP:0000508
26 reduced visual acuity 58 31 very rare (1%) Very rare (<4-1%) HP:0007663
27 neoplasm of the eye 58 31 very rare (1%) Very rare (<4-1%) HP:0100012
28 neoplasm of the lung 58 31 very rare (1%) Very rare (<4-1%) HP:0100526
29 biliary tract obstruction 58 31 very rare (1%) Very rare (<4-1%) HP:0005230
30 abnormal brain fdg positron emission tomography 58 31 very rare (1%) Very rare (<4-1%) HP:0012658
31 intermittent jaundice 58 31 very rare (1%) Very rare (<4-1%) HP:0001046
32 elevated alkaline phosphatase of hepatic origin 58 31 very rare (1%) Very rare (<4-1%) HP:0010638
33 intrahepatic cholestasis with episodic jaundice 58 31 very rare (1%) Very rare (<4-1%) HP:0006575
34 elevated gamma-glutamyltransferase level 31 very rare (1%) HP:0030948
35 elevated alpha-fetoprotein 58 Excluded (0%)
36 neoplasm of the nervous system 58 Very rare (<4-1%)
37 neuroendocrine neoplasm 58 Obligate (100%)
38 elevated gamma-glutamyltransferase activity 58 Very rare (<4-1%)
39 elevated carcinoembryonic antigen level 58 Excluded (0%)
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Drugs & Therapeutics for Primary Hepatic Neuroendocrine Carcinoma

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Search Clinical Trials , NIH Clinical Center for Primary Hepatic Neuroendocrine Carcinoma

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Genetic Tests for Primary Hepatic Neuroendocrine Carcinoma

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Anatomical Context for Primary Hepatic Neuroendocrine Carcinoma

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MalaCards organs/tissues related to Primary Hepatic Neuroendocrine Carcinoma:

40
Liver, Eye, Brain, Heart, Lung
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Publications for Primary Hepatic Neuroendocrine Carcinoma

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Articles related to Primary Hepatic Neuroendocrine Carcinoma:

(show all 44)
# Title Authors PMID Year
1
Two-in-one: A pooled analysis of primary hepatic neuroendocrine carcinoma combined/collided with hepatocellular carcinoma. 61
32359724 2020
2
Elevated procalcitonin levels in primary hepatic neuroendocrine carcinoma: Case report and literature review. 61
32756098 2020
3
Primary Hepatic Neuroendocrine Carcinoma : Amphicrine Type. 61
32723176 2020
4
Primary hepatic neuroendocrine carcinoma coexisting with distal cholangiocarcinoma: A case report and review of the literature. 61
32590784 2020
5
Primary hepatic neuroendocrine carcinoma with massive hepatomegaly in a young-old woman. 61
31429180 2019
6
[Repeat Hepatectomy for Primary Hepatic Neuroendocrine Carcinoma in the Remnant Liver Nine Years after the First Resection]. 61
31631169 2019
7
Primary Hepatic Neuroendocrine Carcinoma Treated with Doxorubicin and Cyclophosphamide in a Dog. 61
30870605 2019
8
Primary hepatic neuroendocrine carcinoma: report of two cases and literature review. 61
29507528 2018
9
[A Case of Mixed Hepatocellular and Primary Hepatic Neuroendocrine Carcinomas with Remnant Liver Recurrence and Rapid Exacerbation]. 61
29394763 2017
10
Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report. 61
28647212 2017
11
Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. 61
28895097 2017
12
Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature. 61
27895410 2016
13
[A Case of Composite Hepatocellular Carcinoma and Neuroendocrine Carcinoma in a Patient with Liver Cirrhosis Caused by Chronic Hepatitis B]. 61
27554219 2016
14
Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review. 61
27384317 2016
15
Primary Hepatic Neuroendocrine Carcinoma: Case Reports and Review of the Literature. 61
26882787 2016
16
[Diagnosis and treatment of primary hepatic neuroendocrine carcinoma]. 61
26463150 2015
17
Hepatic primary neuroendocrine carcinoma: about a new case. 61
26161177 2015
18
Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. 61
26184027 2014
19
Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma. 61
25051214 2014
20
Imaging and pathological features of primary hepatic neuroendocrine carcinoma: An analysis of nine cases and review of the literature. 61
24944650 2014
21
Surgery for giant primary neuroendocrine carcinoma of the liver. 61
24146337 2014
22
Diagnosis and therapy of primary hepatic neuroendocrine carcinoma: clinical analysis of 10 cases. 61
24761861 2014
23
Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. 61
23942951 2013
24
Postoperative outcomes of primary hepatic neuroendocrine carcinomas: review article. 61
24575586 2013
25
Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat. 61
23738981 2013
26
Primary hepatic neuroendocrine carcinoma. 61
26155210 2013
27
Combined hepatocellular carcinoma and neuroendocrine carcinoma with sarcomatous change of the liver after transarterial chemoembolization. 61
23094854 2012
28
Clinical features and outcomes of primary hepatic neuroendocrine carcinomas. 61
22414232 2012
29
Neuroendocrine liver metastases: contributions of endoscopy and surgery to primary tumor search. 61
22416174 2012
30
Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. 61
22288038 2012
31
[Primary hepatic neuroendocrine carcinoma]. 61
22716014 2012
32
Primary hepatic neuroendocrine carcinoma with nonbacterial thrombotic endocarditis: a case report. 61
21329891 2011
33
[Case of primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy]. 61
21139365 2010
34
Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. 61
20133228 2010
35
Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case. 61
20107963 2010
36
Primary hepatic neuroendocrine carcinoma in a baboon (Papio sp.). 61
18715267 2009
37
Hyperammonemic encephalopathy in a patient with primary hepatic neuroendocrine carcinoma. 61
19031017 2009
38
Neuroendocrine carcinoma of the liver associated with dermatomyositis: autopsy case and review of the literature. 61
17096733 2006
39
[A case of primary neuroendocrine carcinoma of liver presenting with liver abscess]. 61
17060722 2006
40
Primary hepatic neuroendocrine carcinoma: an underdiagnosed entity. 61
16414542 2006
41
Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case. 61
12658390 2003
42
Primary neuroendocrine carcinoma of the liver: an autopsy case. 61
11844054 2001
43
Primary hepatic neuroendocrine carcinoma with multiple metastases: a case report. 61
8539446 1995
44
Primary hepatic neuroendocrine carcinoma in a child. Morphologic, immunocytochemical, and molecular biologic studies. 61
8453589 1993
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Variations for Primary Hepatic Neuroendocrine Carcinoma

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Expression for Primary Hepatic Neuroendocrine Carcinoma

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Search GEO for disease gene expression data for Primary Hepatic Neuroendocrine Carcinoma.
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Pathways for Primary Hepatic Neuroendocrine Carcinoma

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Pathways related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
10.7 VIM SYP S100B
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GO Terms for Primary Hepatic Neuroendocrine Carcinoma

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Sources for Primary Hepatic Neuroendocrine Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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