MCID: PRM205
MIFTS: 34

Primary Hepatic Neuroendocrine Carcinoma

Categories: Liver diseases, Endocrine diseases, Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Primary Hepatic Neuroendocrine Carcinoma

MalaCards integrated aliases for Primary Hepatic Neuroendocrine Carcinoma:

Name: Primary Hepatic Neuroendocrine Carcinoma 59
Liver Neuroendocrine Carcinoma 73

Characteristics:

Orphanet epidemiological data:

59
primary hepatic neuroendocrine carcinoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: adult,elderly;

Classifications:



Summaries for Primary Hepatic Neuroendocrine Carcinoma

MalaCards based summary : Primary Hepatic Neuroendocrine Carcinoma, also known as liver neuroendocrine carcinoma, is related to esophageal neuroendocrine tumor and ureter small cell carcinoma. An important gene associated with Primary Hepatic Neuroendocrine Carcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, lung and brain, and related phenotypes are ptosis and hepatomegaly

Related Diseases for Primary Hepatic Neuroendocrine Carcinoma

Diseases related to Primary Hepatic Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 esophageal neuroendocrine tumor 10.5 CHGA SYP
2 ureter small cell carcinoma 10.5 CHGA SYP
3 urinary bladder small cell neuroendocrine carcinoma 10.5 CHGA SYP
4 ovarian large-cell neuroendocrine carcinoma 10.5 CHGA SYP
5 auditory system cancer 10.5 CHGA SYP
6 adenoma of the pancreas 10.5 CHGA SYP
7 acinar cell cystadenocarcinoma 10.5 CHGA SYP
8 peritoneal serous adenocarcinoma 10.5 CHGA SYP
9 cellular ependymoma 10.5 CHGA SYP
10 gallbladder small cell carcinoma 10.5 CHGA SYP
11 small cell carcinoma of the bladder 10.5 CHGA SYP
12 gastrointestinal neuroendocrine tumor 10.5 CHGA SYP
13 pulmonary large cell neuroendocrine carcinoma 10.5 CHGA SYP
14 atypical follicular adenoma 10.5 CHGA SYP
15 olfactory nerve neoplasm 10.5 CHGA SYP
16 cauda equina neoplasm 10.5 CHGA SYP
17 pancreatic serous cystadenoma 10.5 CHGA SYP
18 conventional angiosarcoma 10.4 CHGA SYP
19 nodular ganglioneuroblastoma 10.4 CHGA SYP
20 pulmonary sclerosing hemangioma 10.4 CHGA SYP
21 respiratory system benign neoplasm 10.4 CHGA SYP
22 gastric squamous cell carcinoma 10.4 CHGA SYP
23 gastric small cell carcinoma 10.4 CHGA SYP
24 pancreatoblastoma 10.4 CHGA SYP
25 subependymoma 10.4 CHGA SYP
26 carcinoid tumors, intestinal 10.4 CHGA SYP
27 pulmonary blastoma 10.4 CHGA SYP
28 ureter, cancer of 10.4 CHGA SYP
29 hepatitis 10.4
30 tanycytic ependymoma 10.4 CHGA SYP
31 non-functioning pancreatic endocrine tumor 10.4 CHGA SYP
32 pleomorphic xanthoastrocytoma 10.4 CHGA SYP
33 sclerosing hemangioma 10.4 CHGA SYP
34 hepatic tuberculosis 10.4 ALPP GPT
35 central neurocytoma 10.4 CHGA SYP
36 pancreatic cystadenocarcinoma 10.4 CHGA SYP
37 binswanger's disease 10.4 CHGA SYP
38 carcinoid syndrome 10.4 CHGA SYP
39 cranial nerve malignant neoplasm 10.4 CHGA SYP
40 cervix small cell carcinoma 10.4 CHGA SYP
41 cerebellar liponeurocytoma 10.4 CHGA SYP
42 horseshoe kidney 10.4 CHGA SYP
43 large cell neuroendocrine carcinoma 10.3 CHGA SYP
44 epithelioid malignant peripheral nerve sheath tumor 10.3 CHGA S100B
45 fascioliasis 10.3 ALPP GPT
46 gastric tubular adenocarcinoma 10.3 CHGA SYP
47 mixed ductal-endocrine carcinoma 10.3 CHGA SYP
48 breast papillary carcinoma 10.3 CHGA SYP
49 ganglioneuroma 10.3 CHGA SYP
50 cystadenoma 10.3 CHGA SYP

Graphical network of the top 20 diseases related to Primary Hepatic Neuroendocrine Carcinoma:



Diseases related to Primary Hepatic Neuroendocrine Carcinoma

Symptoms & Phenotypes for Primary Hepatic Neuroendocrine Carcinoma

Human phenotypes related to Primary Hepatic Neuroendocrine Carcinoma:

59 32 (show all 38)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 59 32 very rare (1%) Very rare (<4-1%) HP:0000508
2 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
3 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
4 ascites 59 32 frequent (33%) Frequent (79-30%) HP:0001541
5 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
6 elevated hepatic transaminases 59 32 frequent (33%) Frequent (79-30%) HP:0002910
7 reduced visual acuity 59 32 very rare (1%) Very rare (<4-1%) HP:0007663
8 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
9 hepatic cysts 59 32 occasional (7.5%) Occasional (29-5%) HP:0001407
10 chronic fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012432
11 carcinoid tumor 59 32 occasional (7.5%) Occasional (29-5%) HP:0100570
12 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
13 episodic abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002574
14 neoplasm of the eye 59 32 very rare (1%) Very rare (<4-1%) HP:0100012
15 neoplasm of the lung 59 32 very rare (1%) Very rare (<4-1%) HP:0100526
16 abdominal distention 59 32 frequent (33%) Frequent (79-30%) HP:0003270
17 neoplasm of the liver 59 32 obligate (100%) Obligate (100%) HP:0002896
18 elevated alkaline phosphatase of hepatic origin 59 32 very rare (1%) Very rare (<4-1%) HP:0010638
19 abnormal brain fdg positron emission tomography 59 32 very rare (1%) Very rare (<4-1%) HP:0012658
20 nausea 59 32 frequent (33%) Frequent (79-30%) HP:0002018
21 night sweats 59 32 occasional (7.5%) Occasional (29-5%) HP:0030166
22 heart murmur 59 32 occasional (7.5%) Occasional (29-5%) HP:0030148
23 palpitations 59 32 occasional (7.5%) Occasional (29-5%) HP:0001962
24 chronic noninfectious lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002730
25 hepatic encephalopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002480
26 right ventricular failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001708
27 erythematous plaque 59 32 occasional (7.5%) Occasional (29-5%) HP:0025474
28 biliary tract obstruction 59 32 very rare (1%) Very rare (<4-1%) HP:0005230
29 facial telangiectasia 59 32 occasional (7.5%) Occasional (29-5%) HP:0007380
30 intermittent jaundice 59 32 very rare (1%) Very rare (<4-1%) HP:0001046
31 increased serum serotonin 59 32 occasional (7.5%) Occasional (29-5%) HP:0003144
32 bronchospasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0025428
33 intrahepatic cholestasis with episodic jaundice 59 32 very rare (1%) Very rare (<4-1%) HP:0006575
34 elevated gamma-glutamyltransferase activity 59 32 very rare (1%) Very rare (<4-1%) HP:0030948
35 neuroendocrine neoplasm 59 Obligate (100%)
36 neoplasm of the nervous system 59 Very rare (<4-1%)
37 elevated alpha-fetoprotein 59 Excluded (0%)
38 elevated carcinoembryonic antigen level 59 Excluded (0%)

Drugs & Therapeutics for Primary Hepatic Neuroendocrine Carcinoma

Search Clinical Trials , NIH Clinical Center for Primary Hepatic Neuroendocrine Carcinoma

Genetic Tests for Primary Hepatic Neuroendocrine Carcinoma

Anatomical Context for Primary Hepatic Neuroendocrine Carcinoma

MalaCards organs/tissues related to Primary Hepatic Neuroendocrine Carcinoma:

41
Liver, Lung, Brain, Heart, Eye

Publications for Primary Hepatic Neuroendocrine Carcinoma

Articles related to Primary Hepatic Neuroendocrine Carcinoma:

(show all 20)
# Title Authors Year
1
Primary hepatic neuroendocrine carcinoma: report of two cases and literature review. ( 29507528 )
2018
2
Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. ( 28895097 )
2017
3
Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report. ( 28647212 )
2017
4
Primary Hepatic Neuroendocrine Carcinoma: Case Reports and Review of the Literature. ( 26882787 )
2016
5
Diagnosis and therapy of primary hepatic neuroendocrine carcinoma: clinical analysis of 10 cases. ( 24761861 )
2014
6
Imaging and pathological features of primary hepatic neuroendocrine carcinoma: An analysis of nine cases and review of the literature. ( 24944650 )
2014
7
Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma. ( 25051214 )
2014
8
Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. ( 26184027 )
2014
9
Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat. ( 23738981 )
2013
10
Primary hepatic neuroendocrine carcinoma. ( 26155210 )
2013
11
Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. ( 23942951 )
2013
12
Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. ( 22288038 )
2012
13
Primary hepatic neuroendocrine carcinoma with nonbacterial thrombotic endocarditis: a case report. ( 21329891 )
2011
14
Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. ( 20133228 )
2010
15
Hyperammonemic encephalopathy in a patient with primary hepatic neuroendocrine carcinoma. ( 19031017 )
2009
16
Primary hepatic neuroendocrine carcinoma in a baboon (Papio sp.). ( 18715267 )
2009
17
Primary hepatic neuroendocrine carcinoma: an underdiagnosed entity. ( 16414542 )
2006
18
Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case. ( 12658390 )
2003
19
Primary hepatic neuroendocrine carcinoma with multiple metastases: a case report. ( 8539446 )
1995
20
Primary hepatic neuroendocrine carcinoma in a child. Morphologic, immunocytochemical, and molecular biologic studies. ( 8453589 )
1993

Variations for Primary Hepatic Neuroendocrine Carcinoma

Expression for Primary Hepatic Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Primary Hepatic Neuroendocrine Carcinoma.

Pathways for Primary Hepatic Neuroendocrine Carcinoma

Pathways related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.7 S100B SYP VIM

GO Terms for Primary Hepatic Neuroendocrine Carcinoma

Biological processes related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 8.62 S100B SYP

Sources for Primary Hepatic Neuroendocrine Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....