Primary Hepatic Neuroendocrine Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PRM205 MIFTS: 31	Primary Hepatic Neuroendocrine Carcinoma Categories: Cancer diseases, Endocrine diseases, Liver diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

Sources

Aliases & Classifications for Primary Hepatic Neuroendocrine Carcinoma

MalaCards integrated aliases for Primary Hepatic Neuroendocrine Carcinoma:

Name: Primary Hepatic Neuroendocrine Carcinoma ⁵⁸

Liver Neuroendocrine Carcinoma ⁷¹

Characteristics:

Orphanet epidemiological data:

⁵⁸

primary hepatic neuroendocrine carcinoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: adult,elderly;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Liver diseases Endocrine diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of digestive organs

Malignant neoplasm of liver and intrahepatic bile ducts

Malignant neoplasm: Other specified carcinomas of liver

Orphanet: ⁵⁸

Rare hepatic diseases

Rare endocrine diseases

External Ids:

ICD10 via Orphanet ³³ C22.7

Orphanet ⁵⁸ ORPHA100085

UMLS ⁷¹ C3273031

Sources

Summaries for Primary Hepatic Neuroendocrine Carcinoma

MalaCards based summary : Primary Hepatic Neuroendocrine Carcinoma, also known as liver neuroendocrine carcinoma, is related to neuroendocrine carcinoma and carcinoid syndrome. An important gene associated with Primary Hepatic Neuroendocrine Carcinoma is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include liver, lung and eye, and related phenotypes are neoplasm of the liver and hepatomegaly

Sources

Related Diseases for Primary Hepatic Neuroendocrine Carcinoma

Diseases related to Primary Hepatic Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)

#	Related Disease	Score	Top Affiliating Genes
1	neuroendocrine carcinoma	30.9	SYP CHGA
2	carcinoid syndrome	29.8	SYP CHGA
3	parenteral nutrition-associated cholestasis	10.2	GPT ALPP
4	cystadenocarcinoma	10.2	VIM ALPP
5	hepatic tuberculosis	10.2	GPT ALPP
6	granulomatous hepatitis	10.2	GPT ALPP
7	ewing sarcoma of bone	10.2	VIM CHGA
8	liver leiomyosarcoma	10.2	GPT CHGA
9	neuroendocrine tumor	10.2
10	parachordoma	10.2	VIM CHGA
11	extrahepatic cholestasis	10.1	GPT ALPP
12	choledocholithiasis	10.1	GPT ALPP
13	fascioliasis	10.1	GPT ALPP
14	epithelioid malignant peripheral nerve sheath tumor	10.1	S100B CHGA
15	endodermal sinus tumor	10.1	VIM CHGA
16	hepatocellular carcinoma	10.1
17	hydromyelia	10.1	VIM S100B
18	bednar tumor	10.1	VIM S100B
19	eccrine porocarcinoma	10.1	VIM S100B
20	cutaneous leiomyosarcoma	10.0	VIM S100B
21	obstructive jaundice	10.0	GPT ALPP
22	odontogenic myxoma	10.0	VIM S100B
23	embryonal sarcoma	10.0	VIM S100B
24	ossifying fibromyxoid tumor	10.0	VIM S100B
25	polymorphous low-grade adenocarcinoma	10.0	VIM S100B
26	fibrous meningioma	10.0	VIM S100B
27	dendritic cell tumor	10.0	VIM S100B
28	spiradenoma	10.0	VIM S100B
29	optic nerve glioma	10.0	VIM S100B
30	parathyroid adenoma	10.0	CHGA ALPP
31	monophasic synovial sarcoma	10.0	VIM S100B
32	syringoma	10.0	VIM S100B
33	osteochondroma	10.0	VIM S100B
34	pleomorphic liposarcoma	10.0	VIM S100B
35	perineurioma	10.0	VIM S100B
36	cutaneous fibrous histiocytoma	10.0	VIM S100B
37	fibrous histiocytoma	10.0	VIM S100B
38	acute cystitis	10.0	VIM GPT
39	budd-chiari syndrome	10.0	VIM CHGA
40	spindle cell sarcoma	10.0	VIM S100B
41	ureter small cell carcinoma	10.0	SYP CHGA
42	small cell carcinoma	10.0	SYP CHGA
43	ovarian large-cell neuroendocrine carcinoma	10.0	SYP CHGA
44	meningioma, radiation-induced	10.0	VIM S100B
45	small cell carcinoma of the bladder	10.0	SYP CHGA
46	acinar cell cystadenocarcinoma	10.0	SYP CHGA
47	vulvar eccrine porocarcinoma	10.0	SYP CHGA
48	amelanotic melanoma	10.0	VIM S100B
49	urinary bladder small cell neuroendocrine carcinoma	10.0	SYP CHGA
50	laryngeal neuroendocrine tumor	10.0	SYP CHGA

Graphical network of the top 20 diseases related to Primary Hepatic Neuroendocrine Carcinoma:

Sources

Symptoms & Phenotypes for Primary Hepatic Neuroendocrine Carcinoma

Human phenotypes related to Primary Hepatic Neuroendocrine Carcinoma:

⁵⁸ ³¹ (show all 38)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	neoplasm of the liver ⁵⁸ ³¹	obligate (100%)	Obligate (100%)	HP:0002896
2	hepatomegaly ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002240
3	dyspnea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002094
4	ascites ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001541
5	weight loss ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001824
6	elevated hepatic transaminase ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002910
7	anorexia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002039
8	chronic fatigue ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0012432
9	diarrhea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002014
10	episodic abdominal pain ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002574
11	abdominal distention ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0003270
12	nausea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002018
13	chronic noninfectious lymphadenopathy ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002730
14	heart murmur ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0030148
15	hepatic cysts ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001407
16	carcinoid tumor ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0100570
17	facial telangiectasia ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0007380
18	increased serum serotonin ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003144
19	palpitations ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001962
20	night sweats ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0030166
21	hepatic encephalopathy ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002480
22	right ventricular failure ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001708
23	erythematous plaque ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0025474
24	bronchospasm ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0025428
25	ptosis ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0000508
26	neoplasm of the lung ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0100526
27	reduced visual acuity ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0007663
28	neoplasm of the eye ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0100012
29	elevated alkaline phosphatase of hepatic origin ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0010638
30	abnormal brain fdg positron emission tomography ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0012658
31	elevated gamma-glutamyltransferase activity ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0030948
32	intermittent jaundice ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0001046
33	biliary tract obstruction ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0005230
34	intrahepatic cholestasis with episodic jaundice ⁵⁸ ³¹	very rare (1%)	Very rare (<4-1%)	HP:0006575
35	neuroendocrine neoplasm ⁵⁸		Obligate (100%)
36	neoplasm of the nervous system ⁵⁸		Very rare (<4-1%)
37	elevated alpha-fetoprotein ⁵⁸		Excluded (0%)
38	elevated carcinoembryonic antigen level ⁵⁸		Excluded (0%)

Sources

Drugs & Therapeutics for Primary Hepatic Neuroendocrine Carcinoma

Search Clinical Trials , NIH Clinical Center for Primary Hepatic Neuroendocrine Carcinoma

Sources

Genetic Tests for Primary Hepatic Neuroendocrine Carcinoma

Sources

Anatomical Context for Primary Hepatic Neuroendocrine Carcinoma

MalaCards organs/tissues related to Primary Hepatic Neuroendocrine Carcinoma:

⁴⁰

Liver, Lung, Eye, Brain, Heart, Breast, Bone

Sources

Publications for Primary Hepatic Neuroendocrine Carcinoma

Articles related to Primary Hepatic Neuroendocrine Carcinoma:

(show all 40)

#	Title	Authors	PMID	Year
1	Primary hepatic neuroendocrine carcinoma with massive hepatomegaly in a young-old woman. ⁶¹	Zeng YC...Zhao YH	31429180	2019
2	[Repeat Hepatectomy for Primary Hepatic Neuroendocrine Carcinoma in the Remnant Liver Nine Years after the First Resection]. ⁶¹	Hijikawa T...Sekimoto M	31631169	2019
3	Primary Hepatic Neuroendocrine Carcinoma Treated with Doxorubicin and Cyclophosphamide in a Dog. ⁶¹	Morgan E...Sandy J	30870605	2019
4	Primary hepatic neuroendocrine carcinoma: report of two cases and literature review. ⁶¹	Zhao ZM...Townsend JP	29507528	2018
5	[A Case of Mixed Hepatocellular and Primary Hepatic Neuroendocrine Carcinomas with Remnant Liver Recurrence and Rapid Exacerbation]. ⁶¹	Matsumoto H...Okajima M	29394763	2017
6	Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report. ⁶¹	Okumura Y...Oda Y	28647212	2017
7	Combination therapies for primary hepatic neuroendocrine carcinoma: a case report. ⁶¹	Nakatake R...Kon M	28895097	2017
8	Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature. ⁶¹	Choi GH...Song IH	27895410	2016
9	Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review. ⁶¹	Nishino H...Uemoto S	27384317	2016
10	[A Case of Composite Hepatocellular Carcinoma and Neuroendocrine Carcinoma in a Patient with Liver Cirrhosis Caused by Chronic Hepatitis B]. ⁶¹	Yun EY...Song DH	27554219	2016
11	Primary Hepatic Neuroendocrine Carcinoma: Case Reports and Review of the Literature. ⁶¹	Segura S...Pathan N	26882787	2016
12	[Diagnosis and treatment of primary hepatic neuroendocrine carcinoma]. ⁶¹	Xu K...Yan L	26463150	2015
13	Hepatic primary neuroendocrine carcinoma: about a new case. ⁶¹	Derouich H...Badre W	26161177	2015
14	Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. ⁶¹	Kano Y...Watanabe M	26184027	2014
15	Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma. ⁶¹	Rasmussen JO...Heegaard S	25051214	2014
16	Imaging and pathological features of primary hepatic neuroendocrine carcinoma: An analysis of nine cases and review of the literature. ⁶¹	Chen Z...Huang HJ	24944650	2014
17	Surgery for giant primary neuroendocrine carcinoma of the liver. ⁶¹	Sotiropoulos GC...Kouraklis G	24146337	2014
18	Diagnosis and therapy of primary hepatic neuroendocrine carcinoma: clinical analysis of 10 cases. ⁶¹	Wang LM...Wu JX	24761861	2014
19	Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. ⁶¹	Li RK...Qiang JW	23942951	2013
20	Postoperative outcomes of primary hepatic neuroendocrine carcinomas: review article. ⁶¹	Shinkawa H...Yamazaki O	24575586	2013
21	Necrolytic migratory erythema associated with a glucagon-producing primary hepatic neuroendocrine carcinoma in a cat. ⁶¹	Asakawa MG...Linder KE	23738981	2013
22	Primary hepatic neuroendocrine carcinoma. ⁶¹	Kim JM...Park CK	26155210	2013
23	Combined hepatocellular carcinoma and neuroendocrine carcinoma with sarcomatous change of the liver after transarterial chemoembolization. ⁶¹	Nakanishi C...Satomi S	23094854	2012
24	Clinical features and outcomes of primary hepatic neuroendocrine carcinomas. ⁶¹	Park CH...Park JY	22414232	2012
25	Neuroendocrine liver metastases: contributions of endoscopy and surgery to primary tumor search. ⁶¹	Cerwenka H	22416174	2012
26	Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. ⁶¹	Alekseev D...Obed A	22288038	2012
27	[Primary hepatic neuroendocrine carcinoma]. ⁶¹	Dvorackova J...Plasek J	22716014	2012
28	Primary hepatic neuroendocrine carcinoma with nonbacterial thrombotic endocarditis: a case report. ⁶¹	Lee MH...Hsu YH	21329891	2011
29	[Case of primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy]. ⁶¹	Hasegawa H...Mita E	21139365	2010
30	Primary hepatic neuroendocrine carcinoma: clinical analysis of 11 cases. ⁶¹	Huang YQ...Huang B	20133228	2010
31	Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case. ⁶¹	Akahoshi T...Muto Y	20107963	2010
32	Primary hepatic neuroendocrine carcinoma in a baboon (Papio sp.). ⁶¹	Aloisio F...Hubbard GB	18715267	2009
33	Hyperammonemic encephalopathy in a patient with primary hepatic neuroendocrine carcinoma. ⁶¹	Turken O...Kandemir EG	19031017	2009
34	Neuroendocrine carcinoma of the liver associated with dermatomyositis: autopsy case and review of the literature. ⁶¹	Yasuda E...Shibayama Y	17096733	2006
35	[A case of primary neuroendocrine carcinoma of liver presenting with liver abscess]. ⁶¹	Lee SH...Kim HS	17060722	2006
36	Primary hepatic neuroendocrine carcinoma: an underdiagnosed entity. ⁶¹	Dala R...Cabello-Inchausti B	16414542	2006
37	Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case. ⁶¹	Ishida M...Yamaguchi A	12658390	2003
38	Primary neuroendocrine carcinoma of the liver: an autopsy case. ⁶¹	Kaya G...Fontolliet C	11844054	2001
39	Primary hepatic neuroendocrine carcinoma with multiple metastases: a case report. ⁶¹	Tsuchimochi S...Yoshida H	8539446	1995
40	Primary hepatic neuroendocrine carcinoma in a child. Morphologic, immunocytochemical, and molecular biologic studies. ⁶¹	Hsueh C...Gonzalez-Crussi F	8453589	1993

Sources

Genes for Primary Hepatic Neuroendocrine Carcinoma

Genes related to Primary Hepatic Neuroendocrine Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ALPP	Alkaline Phosphatase, Placental	Protein Coding	6.9	GeneCards inferred via : Publications (show sections)
2	CHGA	Chromogranin A	Protein Coding	6.9	GeneCards inferred via : Publications (show sections)
3	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	6.9	GeneCards inferred via : Publications (show sections)
4	S100B	S100 Calcium Binding Protein B	Protein Coding	6.9	GeneCards inferred via : Publications (show sections)
5	SYP	Synaptophysin	Protein Coding	6.9	GeneCards inferred via : Publications (show sections)
6	VIM	Vimentin	Protein Coding	6.9	GeneCards inferred via : Publications (show sections)

Sources

Variations for Primary Hepatic Neuroendocrine Carcinoma

Sources

Expression for Primary Hepatic Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Primary Hepatic Neuroendocrine Carcinoma.

Sources

Pathways for Primary Hepatic Neuroendocrine Carcinoma

Pathways related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.7	VIM SYP S100B

Sources

GO Terms for Primary Hepatic Neuroendocrine Carcinoma

Biological processes related to Primary Hepatic Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of neuronal synaptic plasticity	GO:0048168	8.62	SYP S100B

Sources

Sources for Primary Hepatic Neuroendocrine Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia