Primary Hypereosinophilic Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

HES-M MCID: PRM149 MIFTS: 35	Primary Hypereosinophilic Syndrome (HES-M) Categories: Blood diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Primary Hypereosinophilic Syndrome

MalaCards integrated aliases for Primary Hypereosinophilic Syndrome:

Name: Primary Hypereosinophilic Syndrome ⁵⁹

Neoplastic Hypereosinophilic Syndrome ⁵⁹

Clonal Hypereosinophilic Syndrome ⁵⁹

Primary Hes ⁵⁹

Hes-M ⁵⁹

Hes-N ⁵⁹

Characteristics:

Orphanet epidemiological data:

⁵⁹

primary hypereosinophilic syndrome
Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Neoplasms

Neoplasms of uncertain or unknown behaviour

Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue

Chronic eosinophilic leukaemia [hypereosinophilic syndrome]

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

Orphanet ⁵⁹ ORPHA314950

ICD10 via Orphanet ³⁴ D47.5

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Summaries for Primary Hypereosinophilic Syndrome

MalaCards based summary : Primary Hypereosinophilic Syndrome, also known as neoplastic hypereosinophilic syndrome, is related to hypereosinophilic syndrome and endomyocardial fibrosis. An important gene associated with Primary Hypereosinophilic Syndrome is ETV6 (ETS Variant 6), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and PI3K-Akt signaling pathway. The drugs Imatinib Mesylate and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and myeloid, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Primary Hypereosinophilic Syndrome

Diseases in the Hypereosinophilic Syndrome family:

Secondary Hypereosinophilic Syndrome

Primary Hypereosinophilic Syndrome

Diseases related to Primary Hypereosinophilic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)

#	Related Disease	Score	Top Affiliating Genes
1	hypereosinophilic syndrome	29.6	FGFR1 FIP1L1 PDGFRA PDGFRB
2	endomyocardial fibrosis	29.5	FIP1L1 PDGFRA
3	loeffler endocarditis	29.3	ETV6 FIP1L1 PDGFRA
4	myeloproliferative disorder, chronic, with eosinophilia	10.1	ETV6 PDGFRB
5	myofibroma	10.1	ETV6 PDGFRB
6	breast secretory carcinoma	10.0	ETV6 FGFR1
7	8p11 myeloproliferative syndrome	10.0	FGFR1 PDGFRB
8	desmoid tumor	10.0	PDGFRA PDGFRB
9	heart sarcoma	10.0	PDGFRA PDGFRB
10	atypical chronic myeloid leukemia	10.0	PDGFRA PDGFRB
11	spinal chordoma	10.0	PDGFRA PDGFRB
12	chordoma	10.0	PDGFRA PDGFRB
13	fibrosarcoma of bone	9.9	PDGFRA PDGFRB
14	leukemia, acute lymphoblastic 3	9.9	ETV6 PDGFRA
15	dysentery	9.9
16	retinoblastoma	9.9
17	dermatofibrosarcoma protuberans	9.9	PDGFRA PDGFRB
18	chronic myelomonocytic leukemia	9.9	ETV6 PDGFRB
19	leiomyosarcoma	9.9	PDGFRA PDGFRB
20	pdgfra-associated chronic eosinophilic leukemia	9.9	FIP1L1 PDGFRA
21	sm-ahnmd	9.9	FIP1L1 PDGFRA
22	hematologic cancer	9.9	ETV6 FGFR1 PDGFRB
23	budd-chiari syndrome	9.8	FIP1L1 PDGFRA
24	myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1	9.8	FGFR1 PDGFRA PDGFRB
25	endocarditis	9.8
26	optic neuritis	9.8
27	neuritis	9.8
28	glioma	9.8	FGFR1 PDGFRA PDGFRB
29	polycythemia vera	9.8	PDGFRA PDGFRB
30	glioblastoma	9.7	FGFR1 PDGFRA PDGFRB
31	mastocytosis	9.7	FIP1L1 PDGFRA PDGFRB
32	hypereosinophilic syndrome, idiopathic	9.7	FIP1L1 PDGFRA PDGFRB
33	corneal dystrophy, subepithelial mucinous	9.7	FIP1L1 PDGFRA PDGFRB
34	ewing sarcoma	9.7	FGFR1 PDGFRA PDGFRB
35	bone marrow cancer	9.6	ETV6 FGFR1 PDGFRA PDGFRB
36	leukemia, chronic myeloid	9.6	ETV6 FGFR1 PDGFRA PDGFRB
37	chronic eosinophilic leukemia	9.5	FGFR1 FIP1L1 PDGFRA PDGFRB
38	systemic mastocytosis	9.5	FGFR1 FIP1L1 PDGFRA PDGFRB
39	myeloproliferative neoplasm	9.5	FGFR1 FIP1L1 PDGFRA PDGFRB

Graphical network of the top 20 diseases related to Primary Hypereosinophilic Syndrome:

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Symptoms & Phenotypes for Primary Hypereosinophilic Syndrome

GenomeRNAi Phenotypes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

²⁶ (show all 31)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00173-A	9.97	PDGFRA
2	Decreased viability	GR00221-A-1	9.97	FGFR1 PDGFRA PDGFRB
3	Decreased viability	GR00221-A-2	9.97	FGFR1
4	Decreased viability	GR00221-A-3	9.97	PDGFRA PDGFRB
5	Decreased viability	GR00221-A-4	9.97	PDGFRA PDGFRB
6	Decreased viability	GR00342-S-1	9.97	PDGFRB
7	Decreased viability	GR00402-S-2	9.97	FGFR1 PDGFRA PDGFRB
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	9.72	FGFR1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-101	9.72	ETV6
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-125	9.72	FGFR1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.72	FGFR1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-129	9.72	PDGFRA
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	9.72	ETV6
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-146	9.72	PDGFRA
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.72	ETV6
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-159	9.72	ETV6
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.72	FGFR1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.72	ETV6
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	9.72	FGFR1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.72	ETV6
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	9.72	ETV6
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-207	9.72	PDGFRA
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.72	PDGFRA
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.72	FGFR1
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.72	FGFR1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.72	PDGFRA
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.72	FGFR1
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	9.72	ETV6
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.72	ETV6 FGFR1 PDGFRA
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.72	FGFR1
31	Increased colony dispersion (increased number of colonies and decreased number of cells per colony)	GR00212-A	8.96	FGFR1 PDGFRA

MGI Mouse Phenotypes related to Primary Hypereosinophilic Syndrome:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.56	ETV6 FGFR1 PDGFRA PDGFRB
2	embryo	MP:0005380	9.46	ETV6 FGFR1 PDGFRA PDGFRB
3	integument	MP:0010771	9.26	ETV6 FGFR1 PDGFRA PDGFRB
4	normal	MP:0002873	8.92	ETV6 FGFR1 PDGFRA PDGFRB

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Drugs & Therapeutics for Primary Hypereosinophilic Syndrome

Drugs for Primary Hypereosinophilic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Imatinib Mesylate		Phase 2		220127-57-1	123596
2	Protein Kinase Inhibitors		Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Imatinib Mesylate in Hypereosinophilic Syndromes	Completed	NCT00787384	Phase 2	Imatinib

Search NIH Clinical Center for Primary Hypereosinophilic Syndrome

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Genetic Tests for Primary Hypereosinophilic Syndrome

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Anatomical Context for Primary Hypereosinophilic Syndrome

MalaCards organs/tissues related to Primary Hypereosinophilic Syndrome:

⁴¹

Bone, Heart, Myeloid, Bone Marrow

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Publications for Primary Hypereosinophilic Syndrome

Articles related to Primary Hypereosinophilic Syndrome:

#	Title	Authors	Year
1	Endomyocardial fibrosis complicating primary hypereosinophilic syndrome. ( 30006894 )	Doyen D...Dellamonica J	2018
2	Purtscher-like retinopathy and primary hypereosinophilic syndrome association. ( 25389731 )	Howard R.C....Zumbro D.S.	2012
3	Purtscher-like retinopathy associated with primary hypereosinophilic syndrome. ( 25391073 )	Gupta O.P....Maguire J.I.	2009
4	Episcleris, arthrofasciitis and hypereosinophilia: primary hypereosinophilic syndrome or atypical Wegener's granulomatosis? ( 17589852 )	do Prado A.D....Staub H.L.	2007
5	Recurrent optic neuritis as the presenting manifestation of primary hypereosinophilic syndrome: a report of two cases. ( 15937435 )	Lincoff N.S....Schlesinger D.	2005
6	Pathologic quiz case: a young woman with eosinophilia and heart failure. Primary hypereosinophilic syndrome with loeffler endocarditis. ( 15628926 )		2005

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Genes for Primary Hypereosinophilic Syndrome

Genes related to Primary Hypereosinophilic Syndrome (5 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ETV6	ETS Variant 6	Protein Coding	350	Gene fusion ⁵⁹
2	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	350	Gene fusion ⁵⁹
3	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	350	Gene fusion ⁵⁹
4	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	350	Gene fusion ⁵⁹
5	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	350	Gene fusion ⁵⁹

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Variations for Primary Hypereosinophilic Syndrome

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Expression for Primary Hypereosinophilic Syndrome

Search GEO for disease gene expression data for Primary Hypereosinophilic Syndrome.

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Pathways for Primary Hypereosinophilic Syndrome

Pathways related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

(show all 31)

#	Super pathways	Score	Top Affiliating Genes
1	Actin Nucleation by ARP-WASP Complex ⁶⁴ Show member pathways Actin Nucleation and Branching ⁶⁴ CDC42 Pathway ⁶⁴ RhoA Pathway ⁶⁴	12.66	FGFR1 PDGFRA PDGFRB
2	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.66	FGFR1 PDGFRA PDGFRB
3	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.55	FGFR1 PDGFRA PDGFRB
4	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.55	FGFR1 PDGFRA PDGFRB
5	Pathways in cancer ³⁷	12.5	FGFR1 PDGFRA PDGFRB
6	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.43	FGFR1 PDGFRA PDGFRB
7	MAPK signaling pathway ³⁷ ¹	12.42	FGFR1 PDGFRA PDGFRB
8	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.38	FGFR1 PDGFRA PDGFRB
9	Downstream signaling events of B Cell Receptor (BCR) ⁶⁶ Show member pathways Activation of RAS in B cells ⁶⁶ Signaling by the B Cell Receptor (BCR) ⁶⁶	12.37	FGFR1 PDGFRA PDGFRB
10	Regulation of actin cytoskeleton ¹ ³⁷	12.29	FGFR1 PDGFRA PDGFRB
11	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.15	FGFR1 PDGFRA PDGFRB
12	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.06	FGFR1 PDGFRA PDGFRB
13	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.05	FGFR1 PDGFRA PDGFRB
14	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	11.92	FGFR1 PDGFRA PDGFRB
15	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	11.84	FGFR1 PDGFRA PDGFRB
16	AKT Signaling Pathway ⁶⁷	11.74	FGFR1 PDGFRA PDGFRB
17	Glioblastoma Multiforme ⁶⁴	11.69	PDGFRA PDGFRB
18	Tyrosine Kinases / Adaptors ⁴	11.67	FGFR1 PDGFRA PDGFRB
19	Gap junction ³⁷	11.58	PDGFRA PDGFRB
20	VEGF Pathway (Tocris) ⁶¹ Show member pathways VEGF Pathway ⁷²	11.53	FGFR1 PDGFRB
21	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.51	FGFR1 PDGFRA
22	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Show member pathways Clozapine Pathway, Pharmacokinetics ⁶¹ Doxepin Pathway, Pharmacokinetics ⁶¹ Fluoxetine Pathway, Pharmacokinetics ⁶¹ Gefitinib Pathway, Pharmacokinetics ⁶¹ Nevirapine Pathway, Pharmacokinetics ⁶¹ Pazopanib Pathway, Pharmacokinetics ⁶¹ Warfarin Pathway, Pharmacokinetics ⁶¹	11.49	PDGFRA PDGFRB
23	G-protein signaling_RhoA regulation pathway ²²	11.39	FGFR1 PDGFRA PDGFRB
24	Angiogenesis (CST) ⁴	11.38	FGFR1 PDGFRA PDGFRB
25	Central carbon metabolism in cancer ³⁷	11.14	FGFR1 PDGFRA PDGFRB
26	G-protein signaling_Cross-talk between Ras-family GTPases ²²	11.05	FGFR1 PDGFRA PDGFRB
27	Cytoskeleton remodeling_Role of PDGFs in cell migration ²²	10.79	PDGFRA PDGFRB
28	Alzheimers Disease Pathway ⁶⁴	10.79	FGFR1 PDGFRA PDGFRB
29	G-protein signaling_Rap2B regulation pathway ²²	10.7	FGFR1 PDGFRA PDGFRB
30	Osteoblast Signaling ¹	10.51	PDGFRA PDGFRB
31	Vemurafenib Pathway, Pharmacodynamics ⁶¹	10.42	FGFR1 PDGFRA PDGFRB

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GO Terms for Primary Hypereosinophilic Syndrome

Cellular components related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic component of plasma membrane	GO:0031226	8.96	PDGFRA PDGFRB
2	receptor complex	GO:0043235	8.8	FGFR1 PDGFRA PDGFRB

Biological processes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	9.87	ETV6 FGFR1 PDGFRA PDGFRB
2	phosphorylation	GO:0016310	9.82	FGFR1 PDGFRA PDGFRB
3	protein phosphorylation	GO:0006468	9.82	FGFR1 PDGFRA PDGFRB
4	negative regulation of apoptotic process	GO:0043066	9.79	FGFR1 PDGFRA PDGFRB
5	positive regulation of cell proliferation	GO:0008284	9.79	FGFR1 PDGFRA PDGFRB
6	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.73	FGFR1 PDGFRA PDGFRB
7	MAPK cascade	GO:0000165	9.72	FGFR1 PDGFRA PDGFRB
8	cell migration	GO:0016477	9.7	FGFR1 PDGFRA PDGFRB
9	peptidyl-tyrosine phosphorylation	GO:0018108	9.69	FGFR1 PDGFRA PDGFRB
10	protein autophosphorylation	GO:0046777	9.67	FGFR1 PDGFRA PDGFRB
11	positive regulation of protein kinase B signaling	GO:0051897	9.65	FGFR1 PDGFRA PDGFRB
12	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.64	PDGFRA PDGFRB
13	wound healing	GO:0042060	9.63	PDGFRA PDGFRB
14	lung development	GO:0030324	9.63	FGFR1 PDGFRA
15	positive regulation of MAPK cascade	GO:0043410	9.63	FGFR1 PDGFRA PDGFRB
16	cell chemotaxis	GO:0060326	9.62	PDGFRA PDGFRB
17	positive regulation of MAP kinase activity	GO:0043406	9.61	FGFR1 PDGFRB
18	positive regulation of fibroblast proliferation	GO:0048146	9.6	PDGFRA PDGFRB
19	skeletal system morphogenesis	GO:0048705	9.59	FGFR1 PDGFRA
20	platelet-derived growth factor receptor signaling pathway	GO:0048008	9.58	PDGFRA PDGFRB
21	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.58	PDGFRA PDGFRB
22	negative regulation of signal transduction	GO:0009968	9.58	FGFR1 PDGFRA PDGFRB
23	cardiac myofibril assembly	GO:0055003	9.54	PDGFRA PDGFRB
24	phosphatidylinositol phosphorylation	GO:0046854	9.54	FGFR1 PDGFRA PDGFRB
25	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.5	FGFR1 PDGFRA PDGFRB
26	retina vasculature development in camera-type eye	GO:0061298	9.43	PDGFRA PDGFRB
27	metanephric glomerular capillary formation	GO:0072277	9.26	PDGFRA PDGFRB
28	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:0038091	9.16	PDGFRA PDGFRB
29	phosphatidylinositol-mediated signaling	GO:0048015	9.13	FGFR1 PDGFRA PDGFRB
30	positive regulation of phospholipase C activity	GO:0010863	8.8	FGFR1 PDGFRA PDGFRB

Molecular functions related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.67	FGFR1 PDGFRA PDGFRB
2	protein kinase activity	GO:0004672	9.65	FGFR1 PDGFRA PDGFRB
3	nucleotide binding	GO:0000166	9.63	FGFR1 PDGFRA PDGFRB
4	transmembrane signaling receptor activity	GO:0004888	9.61	FGFR1 PDGFRA PDGFRB
5	protein tyrosine kinase activity	GO:0004713	9.54	FGFR1 PDGFRA PDGFRB
6	Ras guanyl-nucleotide exchange factor activity	GO:0005088	9.43	FGFR1 PDGFRA PDGFRB
7	platelet-derived growth factor receptor binding	GO:0005161	9.4	PDGFRA PDGFRB
8	platelet-derived growth factor binding	GO:0048407	9.32	PDGFRA PDGFRB
9	vascular endothelial growth factor binding	GO:0038085	9.16	PDGFRA PDGFRB
10	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.13	FGFR1 PDGFRA PDGFRB
11	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.8	FGFR1 PDGFRA PDGFRB

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Sources for Primary Hypereosinophilic Syndrome

¹ BioSystems

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⁴¹ MalaCards

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⁵¹ NDF-RT

⁵² NIH Clinical Center

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⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

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⁶¹ PharmGKB

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Primary Hypereosinophilic Syndrome (HES-M)

Aliases & Classifications for Primary Hypereosinophilic Syndrome

MalaCards integrated aliases for Primary Hypereosinophilic Syndrome:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Primary Hypereosinophilic Syndrome

Related Diseases for Primary Hypereosinophilic Syndrome

Diseases in the Hypereosinophilic Syndrome family:

Diseases related to Primary Hypereosinophilic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Primary Hypereosinophilic Syndrome:

Symptoms & Phenotypes for Primary Hypereosinophilic Syndrome

GenomeRNAi Phenotypes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Primary Hypereosinophilic Syndrome:

Drugs & Therapeutics for Primary Hypereosinophilic Syndrome

Drugs for Primary Hypereosinophilic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Primary Hypereosinophilic Syndrome

Anatomical Context for Primary Hypereosinophilic Syndrome

MalaCards organs/tissues related to Primary Hypereosinophilic Syndrome:

Publications for Primary Hypereosinophilic Syndrome

Articles related to Primary Hypereosinophilic Syndrome:

Genes for Primary Hypereosinophilic Syndrome

Genes related to Primary Hypereosinophilic Syndrome (5 elite genes):

Variations for Primary Hypereosinophilic Syndrome

Expression for Primary Hypereosinophilic Syndrome

Pathways for Primary Hypereosinophilic Syndrome

Pathways related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

GO Terms for Primary Hypereosinophilic Syndrome

Cellular components related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

Biological processes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

Molecular functions related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

Sources for Primary Hypereosinophilic Syndrome