Primary Hypereosinophilic Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

HES-M MCID: PRM149 MIFTS: 31	Primary Hypereosinophilic Syndrome (HES-M) Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Primary Hypereosinophilic Syndrome

MalaCards integrated aliases for Primary Hypereosinophilic Syndrome:

Name: Primary Hypereosinophilic Syndrome ⁵⁸

Neoplastic Hypereosinophilic Syndrome ⁵⁸

Clonal Hypereosinophilic Syndrome ⁵⁸

Primary Hes ⁵⁸

Hes-M ⁵⁸

Hes-N ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

primary hypereosinophilic syndrome
Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Neoplasms of uncertain or unknown behaviour

Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue

Chronic eosinophilic leukaemia [hypereosinophilic syndrome]

Orphanet: ⁵⁸

Rare haematological diseases

External Ids:

ICD10 via Orphanet ³³ D47.5

Orphanet ⁵⁸ ORPHA314950

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Summaries for Primary Hypereosinophilic Syndrome

MalaCards based summary : Primary Hypereosinophilic Syndrome, also known as neoplastic hypereosinophilic syndrome, is related to loeffler endocarditis and hypereosinophilic syndrome. An important gene associated with Primary Hypereosinophilic Syndrome is ETV6 (ETS Variant Transcription Factor 6), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Actin Nucleation by ARP-WASP Complex. The drugs Protein Kinase Inhibitors and Imatinib Mesylate have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Primary Hypereosinophilic Syndrome

Diseases in the Hypereosinophilic Syndrome family:

Secondary Hypereosinophilic Syndrome

Primary Hypereosinophilic Syndrome

Diseases related to Primary Hypereosinophilic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Related Disease	Score	Top Affiliating Genes
1	loeffler endocarditis	29.5	PDGFRA FIP1L1
2	hypereosinophilic syndrome	29.4	PDGFRB PDGFRA FIP1L1 FGFR1
3	endomyocardial fibrosis	29.1	PDGFRB PDGFRA FIP1L1
4	infantile myofibromatosis	10.0	PDGFRB ETV6
5	8p11 myeloproliferative syndrome	10.0	PDGFRB FGFR1
6	pericarditis	10.0
7	b-lymphoblastic leukemia/lymphoma	9.9	FGFR1 ETV6
8	fibrosis of extraocular muscles, congenital, 1	9.9
9	exanthem	9.9
10	endocarditis	9.9
11	optic neuritis	9.9
12	neuritis	9.9
13	salivary gland carcinoma	9.9	FGFR1 ETV6
14	cerebellar angioblastoma	9.9	PDGFRA ETV6
15	leukemia, acute lymphoblastic 3	9.9	PDGFRA ETV6
16	mesenchymal cell neoplasm	9.8	PDGFRB PDGFRA
17	paraganglioma and gastric stromal sarcoma	9.8	PDGFRB PDGFRA
18	desmoid tumor	9.8	PDGFRB PDGFRA
19	pdgfra-associated chronic eosinophilic leukemia	9.8	PDGFRA FIP1L1
20	costello syndrome	9.8	PDGFRB PDGFRA
21	sm-ahnmd	9.8	PDGFRA FIP1L1
22	neurilemmoma	9.8	PDGFRB PDGFRA
23	disseminated eosinophilic collagen disease	9.8	PDGFRA FIP1L1
24	hemangioblastoma	9.8	PDGFRB PDGFRA
25	large cell carcinoma	9.8	PDGFRA FGFR1
26	dermatofibrosarcoma protuberans	9.8	PDGFRB PDGFRA
27	myelofibrosis	9.8	PDGFRB FGFR1 ETV6
28	leiomyosarcoma	9.8	PDGFRB PDGFRA
29	budd-chiari syndrome	9.7	PDGFRA FIP1L1
30	mastocytosis, cutaneous	9.7	PDGFRA FIP1L1
31	chordoma	9.7	PDGFRB PDGFRA
32	hematologic cancer	9.7	PDGFRB FGFR1 ETV6
33	myeloproliferative disorder, chronic, with eosinophilia	9.7	PDGFRB FIP1L1 ETV6
34	pilocytic astrocytoma	9.6	PDGFRB FGFR1
35	myelodysplastic/myeloproliferative neoplasm	9.6	PDGFRB PDGFRA ETV6
36	chronic myelomonocytic leukemia	9.6	PDGFRB PDGFRA ETV6
37	juvenile myelomonocytic leukemia	9.6	PDGFRB PDGFRA ETV6
38	myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1	9.6	PDGFRB PDGFRA FGFR1
39	brain cancer	9.6	PDGFRB PDGFRA ETV6
40	restrictive cardiomyopathy	9.6	PDGFRA FIP1L1
41	gliosarcoma	9.6	PDGFRB PDGFRA FGFR1
42	glioma	9.5	PDGFRB PDGFRA FGFR1
43	hypereosinophilic syndrome, idiopathic	9.5	PDGFRB PDGFRA FIP1L1
44	aggressive systemic mastocytosis	9.5	PDGFRB PDGFRA FIP1L1
45	chronic leukemia	9.5	PDGFRB PDGFRA FIP1L1
46	rhabdomyosarcoma	9.5	PDGFRB PDGFRA FGFR1
47	medulloblastoma	9.4	PDGFRB PDGFRA FGFR1
48	atypical chronic myeloid leukemia	9.3	PDGFRB PDGFRA FGFR1 ETV6
49	leukemia, chronic myeloid	9.3	PDGFRB PDGFRA FGFR1 ETV6
50	glioblastoma	9.3	PDGFRB PDGFRA FGFR1

Graphical network of the top 20 diseases related to Primary Hypereosinophilic Syndrome:

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Symptoms & Phenotypes for Primary Hypereosinophilic Syndrome

GenomeRNAi Phenotypes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

²⁶ (show all 16)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-126	9.81	FGFR1
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-139	9.81	FGFR1 PDGFRA
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-176	9.81	ETV6
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-198	9.81	ETV6
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-40	9.81	FGFR1
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-73	9.81	ETV6 FGFR1 PDGFRA
7	Decreased viability	GR00173-A	9.77	PDGFRA
8	Decreased viability	GR00221-A-1	9.77	FGFR1 PDGFRA PDGFRB
9	Decreased viability	GR00221-A-2	9.77	FGFR1
10	Decreased viability	GR00221-A-3	9.77	PDGFRA PDGFRB
11	Decreased viability	GR00221-A-4	9.77	PDGFRA PDGFRB
12	Decreased viability	GR00249-S	9.77	PDGFRA
13	Decreased viability	GR00342-S-1	9.77	PDGFRB
14	Decreased viability	GR00386-A-1	9.77	FGFR1
15	Decreased viability	GR00402-S-2	9.77	PDGFRA
16	Increased colony dispersion (increased number of colonies and decreased number of cells per colony)	GR00212-A	8.62	FGFR1 PDGFRA

MGI Mouse Phenotypes related to Primary Hypereosinophilic Syndrome:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.26	ETV6 FGFR1 PDGFRA PDGFRB
2	normal	MP:0002873	8.92	ETV6 FGFR1 PDGFRA PDGFRB

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Drugs & Therapeutics for Primary Hypereosinophilic Syndrome

Drugs for Primary Hypereosinophilic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Protein Kinase Inhibitors		Phase 2
2	Imatinib Mesylate		Phase 2		220127-57-1	123596

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Therapeutic and Biological Effects of Imatinib Mesylate in Primary Hypereosinophilic Syndromes	Completed	NCT00787384	Phase 2	Imatinib

Search NIH Clinical Center for Primary Hypereosinophilic Syndrome

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Genetic Tests for Primary Hypereosinophilic Syndrome

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Anatomical Context for Primary Hypereosinophilic Syndrome

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Publications for Primary Hypereosinophilic Syndrome

Articles related to Primary Hypereosinophilic Syndrome:

(show all 14)

#	Title	Authors	PMID	Year
1	A man with abdominal pain and eosinophilia : tissue is the issue. ⁶¹	Crape L...de Clerck F	31950810	2019
2	Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma. ⁶¹	Pagnoux C...Vasculitis Clinical Research Consortium	30652675	2019
3	Endomyocardial fibrosis complicating primary hypereosinophilic syndrome. ⁶¹	Doyen D...Dellamonica J	30006894	2018
4	Purtscher-like retinopathy and primary hypereosinophilic syndrome association. ⁶¹	Howard RC...Zumbro DS	25389731	2012
5	Purtscher-like retinopathy associated with primary hypereosinophilic syndrome. ⁶¹	Gupta OP...Maguire JI	25391073	2009
6	Episcleris, arthrofasciitis and hypereosinophilia: primary hypereosinophilic syndrome or atypical Wegener's granulomatosis? ⁶¹	do Prado AD...Staub HL	17589852	2007
7	The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study. ⁶¹	Baccarani M...Martinelli G	17666373	2007
8	Apoptosis induction by retinoids in eosinophilic leukemia cells: implication of retinoic acid receptor-alpha signaling in all-trans-retinoic acid hypersensitivity. ⁶¹	Robert C...Papp B	16778211	2006
9	[Primary hypereosinophilic syndrome]. ⁶¹	Ballanger F...Hamidou M	16760844	2006
10	Recurrent optic neuritis as the presenting manifestation of primary hypereosinophilic syndrome: a report of two cases. ⁶¹	Lincoff NS...Schlesinger D	15937435	2005
11	Pathologic quiz case: a young woman with eosinophilia and heart failure. Primary hypereosinophilic syndrome with loeffler endocarditis. ⁶¹	Cunningham K...Veinot JP	15628926	2005
12	The role of eosinophils in the pathobiology of Hodgkin's disease. ⁶¹	Pinto A...Carbone A	9209649	1997
13	Progesterone-responsive urticaria and eosinophilia. ⁶¹	Mittman RJ...Bernstein IL	2778236	1989
14	[Idiopathic or primary hypereosinophilic syndrome. Description of 6 cases and review of the literature]. ⁶¹	Lobato-Mendizabal E...Marin-Lopez A	3072631	1988

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Genes for Primary Hypereosinophilic Syndrome

Genes related to Primary Hypereosinophilic Syndrome (5 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ETV6	ETS Variant Transcription Factor 6	Protein Coding	350	Gene fusion ⁵⁸
2	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	350	Gene fusion ⁵⁸
3	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	350	Gene fusion ⁵⁸
4	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	350	Gene fusion ⁵⁸
5	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	350	Gene fusion ⁵⁸

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Variations for Primary Hypereosinophilic Syndrome

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Expression for Primary Hypereosinophilic Syndrome

Search GEO for disease gene expression data for Primary Hypereosinophilic Syndrome.

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Pathways for Primary Hypereosinophilic Syndrome

Pathways related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

(show all 31)

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.66	PDGFRB PDGFRA FGFR1
2	Actin Nucleation by ARP-WASP Complex ⁶³ Show member pathways Actin Nucleation and Branching ⁶³ CDC42 Pathway ⁶³ RhoA Pathway ⁶³	12.62	PDGFRB PDGFRA FGFR1
3	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.55	PDGFRB PDGFRA FGFR1
4	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.55	PDGFRB PDGFRA FGFR1
5	Pathways in cancer ³⁶	12.51	PDGFRB PDGFRA FGFR1
6	MAPK signaling pathway ³⁶ ¹	12.43	PDGFRB PDGFRA FGFR1
7	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.41	PDGFRB PDGFRA FGFR1
8	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.39	PDGFRB PDGFRA FGFR1
9	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.34	PDGFRB PDGFRA FGFR1
10	Regulation of actin cytoskeleton ³⁶ ¹	12.29	PDGFRB PDGFRA FGFR1
11	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	12.12	PDGFRB PDGFRA FGFR1
12	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	12.07	PDGFRB PDGFRA FGFR1
13	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.05	PDGFRB PDGFRA FGFR1
14	Calcium signaling pathway ³⁶	11.96	PDGFRB PDGFRA FGFR1
15	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.92	PDGFRB PDGFRA FGFR1
16	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	11.88	PDGFRB PDGFRA FGFR1
17	Glioblastoma Multiforme ⁶³	11.7	PDGFRB PDGFRA
18	Tyrosine Kinases / Adaptors ⁴	11.67	PDGFRB PDGFRA FGFR1
19	Gap junction ³⁶	11.59	PDGFRB PDGFRA
20	VEGF Pathway (Tocris) ⁶⁰ Show member pathways VEGF Pathway ⁷⁰	11.56	PDGFRB FGFR1
21	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.51	PDGFRA FGFR1
22	G-protein signaling_RhoA regulation pathway ²³	11.38	PDGFRB PDGFRA FGFR1
23	Angiogenesis (CST) ⁴	11.38	PDGFRB PDGFRA FGFR1
24	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Show member pathways Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰ Taxane Pathway, Pharmacokinetics ⁶⁰	11.28	PDGFRB PDGFRA
25	Central carbon metabolism in cancer ³⁶	11.18	PDGFRB PDGFRA FGFR1
26	Pazopanib Pathway, Pharmacokinetics ⁶⁰ Show member pathways Sunitinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.03	PDGFRB PDGFRA
27	Cytoskeleton remodeling_Role of PDGFs in cell migration ²³	10.79	PDGFRB PDGFRA
28	Alzheimers Disease Pathway ⁶³	10.79	PDGFRB PDGFRA FGFR1
29	G-protein signaling_Rap2B regulation pathway ²³	10.7	PDGFRB PDGFRA FGFR1
30	Osteoblast Signaling ¹	10.51	PDGFRB PDGFRA
31	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	10.43	PDGFRB PDGFRA FGFR1

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GO Terms for Primary Hypereosinophilic Syndrome

Cellular components related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic component of plasma membrane	GO:0031226	8.96	PDGFRB PDGFRA
2	receptor complex	GO:0043235	8.8	PDGFRB PDGFRA FGFR1

Biological processes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.79	PDGFRB PDGFRA FGFR1
2	protein phosphorylation	GO:0006468	9.78	PDGFRB PDGFRA FGFR1
3	positive regulation of cell proliferation	GO:0008284	9.77	PDGFRB PDGFRA FGFR1
4	MAPK cascade	GO:0000165	9.71	PDGFRB PDGFRA FGFR1
5	cell migration	GO:0016477	9.7	PDGFRB PDGFRA FGFR1
6	positive regulation of protein kinase B signaling	GO:0051897	9.69	PDGFRB PDGFRA FGFR1
7	protein autophosphorylation	GO:0046777	9.67	PDGFRB PDGFRA FGFR1
8	peptidyl-tyrosine phosphorylation	GO:0018108	9.63	PDGFRB PDGFRA FGFR1
9	wound healing	GO:0042060	9.61	PDGFRB PDGFRA
10	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.61	PDGFRB PDGFRA FGFR1
11	cell chemotaxis	GO:0060326	9.6	PDGFRB PDGFRA
12	positive regulation of MAP kinase activity	GO:0043406	9.58	PDGFRB FGFR1
13	positive regulation of fibroblast proliferation	GO:0048146	9.58	PDGFRB PDGFRA
14	skeletal system morphogenesis	GO:0048705	9.57	PDGFRA FGFR1
15	platelet-derived growth factor receptor signaling pathway	GO:0048008	9.56	PDGFRB PDGFRA
16	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.55	PDGFRB PDGFRA
17	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.54	PDGFRB PDGFRA FGFR1
18	positive regulation of kinase activity	GO:0033674	9.5	PDGFRB PDGFRA FGFR1
19	cardiac myofibril assembly	GO:0055003	9.48	PDGFRB PDGFRA
20	retina vasculature development in camera-type eye	GO:0061298	9.4	PDGFRB PDGFRA
21	metanephric glomerular capillary formation	GO:0072277	9.26	PDGFRB PDGFRA
22	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:0038091	9.16	PDGFRB PDGFRA
23	phosphatidylinositol-mediated signaling	GO:0048015	9.13	PDGFRB PDGFRA FGFR1
24	positive regulation of phospholipase C activity	GO:0010863	8.8	PDGFRB PDGFRA FGFR1

Molecular functions related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.61	PDGFRB PDGFRA FGFR1
2	protein kinase activity	GO:0004672	9.58	PDGFRB PDGFRA FGFR1
3	growth factor binding	GO:0019838	9.37	PDGFRB PDGFRA
4	protein tyrosine kinase activity	GO:0004713	9.33	PDGFRB PDGFRA FGFR1
5	platelet-derived growth factor receptor binding	GO:0005161	9.32	PDGFRB PDGFRA
6	platelet-derived growth factor binding	GO:0048407	9.26	PDGFRB PDGFRA
7	vascular endothelial growth factor binding	GO:0038085	8.96	PDGFRB PDGFRA
8	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.8	PDGFRB PDGFRA FGFR1

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Sources for Primary Hypereosinophilic Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Primary Hypereosinophilic Syndrome (HES-M)

Aliases & Classifications for Primary Hypereosinophilic Syndrome

MalaCards integrated aliases for Primary Hypereosinophilic Syndrome:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Primary Hypereosinophilic Syndrome

Related Diseases for Primary Hypereosinophilic Syndrome

Diseases in the Hypereosinophilic Syndrome family:

Diseases related to Primary Hypereosinophilic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Primary Hypereosinophilic Syndrome:

Symptoms & Phenotypes for Primary Hypereosinophilic Syndrome

GenomeRNAi Phenotypes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Primary Hypereosinophilic Syndrome:

Drugs & Therapeutics for Primary Hypereosinophilic Syndrome

Drugs for Primary Hypereosinophilic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Primary Hypereosinophilic Syndrome

Anatomical Context for Primary Hypereosinophilic Syndrome

Publications for Primary Hypereosinophilic Syndrome

Articles related to Primary Hypereosinophilic Syndrome:

Genes for Primary Hypereosinophilic Syndrome

Genes related to Primary Hypereosinophilic Syndrome (5 elite genes):

Variations for Primary Hypereosinophilic Syndrome

Expression for Primary Hypereosinophilic Syndrome

Pathways for Primary Hypereosinophilic Syndrome

Pathways related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

GO Terms for Primary Hypereosinophilic Syndrome

Cellular components related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

Biological processes related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

Molecular functions related to Primary Hypereosinophilic Syndrome according to GeneCards Suite gene sharing:

Sources for Primary Hypereosinophilic Syndrome