Primary Hypertrophic Osteoarthropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

PDP MCID: PRM018 MIFTS: 56	Primary Hypertrophic Osteoarthropathy (PDP) Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Primary Hypertrophic Osteoarthropathy

MalaCards integrated aliases for Primary Hypertrophic Osteoarthropathy:

Name: Primary Hypertrophic Osteoarthropathy ¹² ²⁰ ⁵⁸ ³⁶ ¹⁵

Pachydermoperiostosis ⁷³ ²⁰ ⁵⁸ ⁵⁴

Idiopathic Hypertrophic Osteoarthropathy ²⁰ ⁵⁸

Osteoarthropathy, Primary Hypertrophic ⁴⁴ ⁷⁰

Pachydermoperiostosis Syndrome ¹² ²⁹

Pdp ²⁰ ⁵⁸

Touraine-Solente-Gole Syndrome ⁵⁸

Touraine Solente Gole Syndrome ²⁰

Pachydermoperiostosis of Nail ¹²

Pho ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

primary hypertrophic osteoarthropathy
Inheritance: Autosomal recessive; Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

pachydermoperiostosis
Inheritance: Autosomal recessive; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases Genetic diseases
Anatomical: Bone diseases Skin diseases Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³² ³³

Diseases of the musculoskeletal system and connective tissue

Other osteopathies

Other disorders of bone

Other hypertrophic osteoarthropathy

Orphanet: ⁵⁸

Rare bone diseases

Rare skin diseases

Developmental anomalies during embryogenesis

External Ids:

Disease Ontology ¹² DOID:14283

KEGG ³⁶ H00457

MeSH ⁴⁴ D010004

NCIt ⁵⁰ C85023

SNOMED-CT ⁶⁷ 88220006

ICD10 ³² M89.4

MESH via Orphanet ⁴⁵ D010004

ICD10 via Orphanet ³³ M89.4

UMLS via Orphanet ⁷¹ C0029411

Orphanet ⁵⁸ ORPHA248095 ORPHA2796

UMLS ⁷⁰ C0029411

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Summaries for Primary Hypertrophic Osteoarthropathy

GARD : ²⁰ Pachydermoperiostosis is a rare disorder characterized by clubbing of the fingers and toes ; thickening of the skin of the face (pachyderma); excessive sweating ( hyperhidrosis ); and new bone formation associated with joint pain. Other features may include congenital heart disease and delayed closure of fontanelles. This condition typically appears during childhood or adolescence, often around the time of puberty, and progresses slowly for about ten years. Both autosomal dominant and autosomal recessive inheritance has been reported. Mutations in the HPGD gene have been found in those with the autosomal recessive form of this condition. Treatment is aimed at addressing the specific symptoms present in each individual and may include nonsteroidal anti-inflammatory medications for pain and swelling of joints, retinoid treatment of skin symptoms, and plastic surgery for facial involvement.

MalaCards based summary : Primary Hypertrophic Osteoarthropathy, also known as pachydermoperiostosis, is related to hypertrophic osteoarthropathy, primary, autosomal recessive, 1 and acroosteolysis, and has symptoms including arthralgia, flushing and metatarsalgia. An important gene associated with Primary Hypertrophic Osteoarthropathy is SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Celecoxib Pathway, Pharmacodynamics. The drugs Etoricoxib and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lung, and related phenotypes are hyperhidrosis and abnormal cortical bone morphology

KEGG : ³⁶ Primary hypertrophic osteoarthropathy (PHO) is a familial disorder with delayed cranial suture closure, digital clubbing, arthropathy, acro-osteolysis, periostosis, and pachydermia. Mutations in HPGD gene and SLCO2A1 gene, which encodes 15-hydroxyprostaglandin dehydrogenase and prostaglandin transporter, were reported.

Wikipedia : ⁷³ Pachydermoperiostosis (PDP) is a rare genetic disorder that affects both bones and skin. Other names are... more...

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Related Diseases for Primary Hypertrophic Osteoarthropathy

Diseases in the Primary Hypertrophic Osteoarthropathy family:

Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant	Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 2	Secondary Hypertrophic Osteoarthropathy

Diseases related to Primary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)

#	Related Disease	Score	Top Affiliating Genes
1	hypertrophic osteoarthropathy, primary, autosomal recessive, 1	31.7	SLCO2A1 HPGD
2	acroosteolysis	30.6	SLCO2A1 HPGD
3	secondary hypertrophic osteoarthropathy	30.5	SLCO2A1 HPGD
4	patent ductus arteriosus 1	29.4	SLCO2A1 SLC2A10 PTGER3 HPGD
5	hypertrophic osteoarthropathy, primary, autosomal recessive, 2	11.7
6	pyruvate dehydrogenase phosphatase deficiency	11.3
7	hypertrophic osteoarthropathy, primary, autosomal dominant	11.0
8	cutis verticis gyrata	10.6
9	psoriatic arthritis	10.4
10	fissured tongue	10.4
11	skin disease	10.4
12	seborrheic dermatitis	10.4
13	arthropathy	10.3
14	periostitis	10.3
15	myelofibrosis	10.3
16	gastritis	10.3
17	ptosis	10.2
18	crohn's disease	10.2
19	scleroderma, familial progressive	10.1
20	deficiency anemia	10.1
21	biliary atresia	10.1
22	hyperostosis	10.1
23	pulmonary fibrosis	10.1
24	hypokalemia	10.1
25	liver cirrhosis	10.1
26	juvenile rheumatoid arthritis	10.1
27	digital clubbing, isolated congenital	10.0
28	dermatitis, atopic	10.0
29	rosai-dorfman disease	10.0
30	osteoporosis	10.0
31	bone mineral density quantitative trait locus 8	10.0
32	bone mineral density quantitative trait locus 15	10.0
33	erythrokeratoderma ''en cocardes''	10.0
34	rare genetic skin disease	10.0
35	spondyloarthropathy 1	10.0
36	hypervitaminosis a	10.0
37	calvarial hyperostosis	10.0
38	inflammatory bowel disease	10.0
39	scoliosis	10.0
40	bone disease	10.0
41	bone resorption disease	10.0
42	osteonecrosis	10.0
43	osteomyelitis	10.0
44	glucose intolerance	10.0
45	gastric ulcer	10.0
46	palindromic rheumatism	10.0
47	iron deficiency anemia	10.0
48	inflammatory spondylopathy	10.0
49	plica syndrome	10.0
50	keratosis	10.0

Graphical network of the top 20 diseases related to Primary Hypertrophic Osteoarthropathy:

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Symptoms & Phenotypes for Primary Hypertrophic Osteoarthropathy

Human phenotypes related to Primary Hypertrophic Osteoarthropathy:

⁵⁸ ³¹ (show all 41)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	hyperhidrosis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000975
2	abnormal cortical bone morphology ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0003103
3	abnormality of epiphysis morphology ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0005930
4	seborrheic dermatitis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001051
5	osteomyelitis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002754
6	bone pain ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002653
7	ptosis ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0000508
8	coarse facial features ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0000280
9	arthritis ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001369
10	acne ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001061
11	abnormal fingernail morphology ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001231
12	arthralgia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002829
13	joint swelling ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001386
14	clubbing of toes ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0100760
15	abnormal hair quantity ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0011362
16	limitation of joint mobility ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001376
17	osteolysis ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002797
18	cutis gyrata of scalp ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0010541
19	scoliosis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002650
20	splenomegaly ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001744
21	hepatomegaly ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002240
22	avascular necrosis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0010885
23	malabsorption ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002024
24	anemia ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001903
25	palmoplantar keratoderma ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000982
26	osteoporosis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000939
27	neoplasm of the skin ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0008069
28	gastrointestinal hemorrhage ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002239
29	peptic ulcer ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0004398
30	gynecomastia ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000771
31	genu varum ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002970
32	small hand ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0200055
33	cerebral palsy ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0100021
34	neoplasm of the lung ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0100526
35	abnormal hair pattern ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0010720
36	abnormality of bone marrow cell morphology ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0005561
37	growth hormone excess ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000845
38	impaired temperature sensation ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0010829
39	eczematoid dermatitis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000976
40	thickened skin ⁵⁸		Very frequent (99-80%)
41	edema ⁵⁸		Frequent (79-30%)

UMLS symptoms related to Primary Hypertrophic Osteoarthropathy:

arthralgia; flushing; metatarsalgia

GenomeRNAi Phenotypes related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

²⁶ (show all 16)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	9.58	PTGER3
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-146	9.58	ERF PTGER3 SLCO4A1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-172	9.58	PTGER3
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.58	PTGER3
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-18	9.58	ERF
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-181	9.58	SLCO4A1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-206	9.58	PTGER3
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	9.58	PTGER3
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-216	9.58	SLCO4A1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.58	ERF
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.58	PTGER3
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.58	ERF
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-56	9.58	SLCO4A1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-77	9.58	ERF
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.58	SLCO4A1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-82	9.58	ERF

MGI Mouse Phenotypes related to Primary Hypertrophic Osteoarthropathy:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.61	ERF HPGD KDM4D PTGER3 PTGES SLC17A5
2	renal/urinary system	MP:0005367	9.02	ERF PTGER3 SLC2A10 SLC6A19 SLCO2A1

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Drugs & Therapeutics for Primary Hypertrophic Osteoarthropathy

Drugs for Primary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Etoricoxib

Approved, Investigational

Phase 3

202409-33-4

123619

Synonyms:

202409-33-4

5CH

5-chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine

5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine

5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulphonyl)phenyl)pyridine

5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine

5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl

5-Chloro-3-(4-methanesulphonyl-phenyl)-6'-methyl-[2,3']bipyridinyl

5-chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine

5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine

5-Chloro-6'-methyl-3-(p-(methylsulphonyl)phenyl)-2,3'-bipyridine

5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine

AC1L3WZM

Algix

Arcoxia

C11718

C422649

CHEBI:106706

CHEBI:6339

CHEMBL416146

CID123619

D03710

DB01628

DB07166

Etoricoxib

étoricoxib

Etoricoxib (USAN/INN)

Etoricoxib [USAN:INN:BAN]

Etoricoxibe

Etoricoxibum

FT-0082494

HMS2090A05

L001141

L791456

L-791456

LS-181802

Merck Sharp & Dohme brand of etoricoxib

MK 0663

MK 663

MK-0663

MK-663

MolPort-003-847-339

NCGC00164578-01

Nucoxia

Tauxib

UNII-WRX4NFY03R

ZINC00579472

Analgesics, Non-Narcotic

Phase 3

Cyclooxygenase 2 Inhibitors

Phase 3

Analgesics

Phase 3

Antirheumatic Agents

Phase 3

Cyclooxygenase Inhibitors

Phase 3

Anti-Inflammatory Agents

Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Application of COX-2 Inhibitor for Treatment of Primary Hypertrophic Osteoarthropathy	Unknown status	NCT02438709	Phase 3	COX-2 inhibitor
2	Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study	Unknown status	NCT02873182

Search NIH Clinical Center for Primary Hypertrophic Osteoarthropathy

Cochrane evidence based reviews: osteoarthropathy, primary hypertrophic

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Genetic Tests for Primary Hypertrophic Osteoarthropathy

Genetic tests related to Primary Hypertrophic Osteoarthropathy:

#	Genetic test	Affiliating Genes
1	Pachydermoperiostosis Syndrome ²⁹

Sources

Anatomical Context for Primary Hypertrophic Osteoarthropathy

MalaCards organs/tissues related to Primary Hypertrophic Osteoarthropathy:

⁴⁰

Bone, Bone Marrow, Lung, Skin, Spinal Cord, Endothelial, Tongue

Sources

Publications for Primary Hypertrophic Osteoarthropathy

Articles related to Primary Hypertrophic Osteoarthropathy:

(show top 50) (show all 477)

#	Title	Authors	PMID	Year
1	Digital clubbing as the predominant manifestation of hypertrophic osteoarthropathy caused by pathogenic variants in HPGD in three Indian families. ⁶¹ ⁶	Radhakrishnan P...Girisha KM	32282352	2020
2	A novel recessive 15-hydroxyprostaglandin dehydrogenase mutation in a family with primary hypertrophic osteoarthropathy. ⁶¹ ⁶	Erken E...Tolun A	24533558	2015
3	Primary hypertrophic osteoarthropathy caused by homozygous deletion in HPGD gene in a family: changing clinical and radiological findings with long-term follow-up. ⁶¹ ⁶	Tuysuz B...Gunel M	24816859	2014
4	The complete type of pachydermoperiostosis: a novel nonsense mutation p.E141* of the SLCO2A1 gene. ⁶¹ ⁶	Niizeki H...Kudoh J	24929850	2014
5	Three novel mutations in the SLCO2A1 gene in two Chinese families with primary hypertrophic osteoarthropathy. ⁶¹ ⁶	Cheng R...Yao Z	24153155	2013
6	Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis. ⁶¹ ⁶	Sasaki T...Kudoh J	22906430	2012
7	Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis. ⁶¹ ⁶	Diggle CP...Bonthron DT	22553128	2012
8	Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing. ⁶¹ ⁶	Seifert W...Horn D	22331663	2012
9	Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy. ⁶¹ ⁶	Zhang Z...Liu Y	22197487	2012
10	Homozygous mutations in the 15-hydroxyprostaglandin dehydrogenase gene in patients with primary hypertrophic osteoarthropathy. ⁶¹ ⁶	Yuksel-Konuk B...Tekin M	19306095	2009
11	Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. ⁶ ⁶¹	Uppal S...Bonthron DT	18500342	2008
12	Pachydermoperiostosis-critical analysis with report of five unusual cases. ⁶ ⁶¹	Latos-Bielenska A...Kozlowski K	17285282	2007
13	Cranio-osteoarthropathy in sibs. ⁶ ⁶¹	Dabir T...Hennekam RC	17551338	2007
14	Pachydermoperiostosis: an update. ⁶¹ ⁶	Castori M...Dallapiccola B	16283874	2005
15	Pachydermoperiostosis in childhood. ⁶ ⁶¹	Sinha GP...Bennett CP	9402870	1997
16	Common and recurrent HPGD mutations in Caucasian individuals with primary hypertrophic osteoarthropathy. ⁵⁴ ⁶¹	Diggle CP...Bonthron DT	20299379	2010
17	A novel homozygous splice site mutation in the HPGD gene causes mild primary hypertrophic osteoarthropathy. ⁶¹ ⁵⁴	Sinibaldi L...Dallapiccola B	20406614	2010
18	HPGD mutations cause cranioosteoarthropathy but not autosomal dominant digital clubbing. ⁶¹ ⁵⁴	Seifert W...Horn D	19568269	2009
19	SLCO2A1 gene is the causal gene for both primary hypertrophic osteoarthropathy and hereditary chronic enteropathy. ⁶¹	Umeno J...Torisu T	33575166	2021
20	Establishment of a novel human iPSC line (SDQLCHi032-A) derived from a patient with primary hypertrophic osteoarthropathy caused by HPGD homozygous mutation. ⁶¹	Li Y...Liu Y	33550138	2021
21	Pachydermoperiostosis Presenting With Vision Loss Secondary to Severe Phlyctenular Keratoconjunctivitis. ⁶¹	Cheng SK...Rizzuti AE	33758137	2021
22	Rare gastric manifestations in primary pachydermoperiostosis. ⁶¹	Chen X...Hu Q	33555339	2021
23	Frontal lifting using a tissue expander in pachydermoperiostosis: A case report. ⁶¹	Cunha DJD...Ramos JLM	33505684	2021
24	Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action. ⁶¹	Nakanishi T...Umeno J	33465398	2021
25	[Clinical and genetic characteristics of patients with chronic enteropathy associated with SLCO2A1 gene]. ⁶¹	Wang Q...Qian JM	33397021	2021
26	Primary hypertrophic osteoarthropathy with severe arthralgia identified by gene mutation of SLCO2A1. ⁶¹	Ishizuka T...Niizeki H	33308032	2021
27	Incomplete Pachydermoperiostosis Associated With Excessive Alcohol Intake. ⁶¹	Willis E...Fang MA	31295153	2020
28	[Primary hypertrophic osteoarthropathy with renal hypokalemia: a case report]. ⁶¹	Jiang RM...Niu M	32838506	2020
29	Diagnosis and Management of a Patient With Primary Hypertrophic Osteoarthropathy With SCLO2A1 Pathogenic Variants in Vietnam. ⁶¹	Tran TH...Van Tran K	32833909	2020
30	Paravertebral extramedullary haemopoiesis in a patient with pachydermoperiostosis. ⁶¹	Souto Filho JTD...Figueiredo LCS	32266716	2020
31	Pachydermoperiostosis: Classic Presentation of a Rare Disease. ⁶¹	Kharbanda R...Gupta L	32676559	2020
32	Incomplete primary hypertrophic osteoarthropathy. ⁶¹	Prasad A...Bhagirathi Mallikarjunaswamy M	32404375	2020
33	Characteristic Facial Appearance Was the Key to Diagnosing Chronic Enteropathy Associated with <i>SLCO2A1</i>-associated Primary Hypertrophic Osteoarthropathy. ⁶¹	Sonoda A...Murakami K	31611528	2020
34	Pachydermoperiostosis mimicking the acral abnormalities of acromegaly. ⁶¹	Marques P...Korbonits M	31916215	2020
35	Complete form of pachydermoperiostosis. ⁶¹	Honorio MLP...Costa VLDC	31889594	2020
36	Characterization of Mineral and Bone Metabolism Biomarkers in a Chinese Consanguineous Twin Family with Primary Hypertrophic Osteoarthropathy. ⁶¹	Li N...Zhao L	33343660	2020
37	Impaired bone microarchitecture in distal interphalangeal joints in patients with primary hypertrophic osteoarthropathy assessed by high-resolution peripheral quantitative computed tomography. ⁶¹	Pang Q...Qin L	31646353	2020
38	Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis. ⁶¹	Tsuzuki Y...Imaeda H	33328413	2020
39	Pachydermoperiostosis: A clinicopathological description. ⁶¹	Tabatabaei SA...Nozarian Z	31844800	2019
40	Primary hypertrophic osteoarthropathy related gastrointestinal complication has distinctive clinical and pathological characteristics: two cases report and review of the literature. ⁶¹	Wang Q...Wu D	31878983	2019
41	Pachydermoperiostosis Associated with Myelofibrosis: A Rare Case Report. ⁶¹	Secchin P...Magalhaes TC	31896854	2019
42	A case of primary hypertrophic osteoarthropathy: Management considerations. ⁶¹	Rostom H...Javaid MK	31647173	2019
43	A novel mutation in the SLCO2A1 gene in a Chinese family with pachydermoperiostosis. ⁶¹	Xiao J...Zhang L	30931527	2019
44	Complete form of pachydermoperiostosis with cutis verticis gyrata resulting from the SLCO2A1 gene mutation. ⁶¹	Li X...Jiang X	30880718	2019
45	Novel SLCO2A1compound heterozygous mutation causing primary hypertrophic osteoarthropathy with Bartter-like hypokalemia in a Chinese family. ⁶¹	Jiang Y...Xia WB	31004291	2019
46	Touraine-Solente-Gole syndrome: Clinical manifestation with bilateral true eyelid ptosis. ⁶¹	Akaranuchat N...Limsuvan P	32158879	2019
47	Bisphosphonates use in Pachydermoperiostosis. ⁶¹	Jagdish RK...Shailly	31561698	2019
48	Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial. ⁶¹	Yuan L...Xia WB	31508314	2019
49	The first case of primary hypertrophic osteoarthropathy with soft tissue giant tumors caused by HPGD loss-of-function mutation. ⁶¹	Pang Q...Xia W	31063976	2019
50	Inflammatory variant of pachydermoperiostosis responding to methotrexate: a report of two cases. ⁶¹	Vaidya B...Nakarmi S	31007935	2019

Sources

Genes for Primary Hypertrophic Osteoarthropathy

Genes related to Primary Hypertrophic Osteoarthropathy (2 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SLCO2A1	Solute Carrier Organic Anion Transporter Family Member 2A1	Protein Coding	802.97	Pathogenic ⁶ Causative germline mutation (loss of function) ⁵⁸ Likely pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)	22197487 22906430 24929850 (more) 22331663
2	HPGD	15-Hydroxyprostaglandin Dehydrogenase	Protein Coding	800.57	Pathogenic ⁶ Causative germline mutation ⁵⁸ Likely pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18500342 20406614 20299379 (more) 19568269
3	SLCO3A1	Solute Carrier Organic Anion Transporter Family Member 3A1	Protein Coding	5.72	DISEASES inferred ¹⁵
4	SLCO4A1	Solute Carrier Organic Anion Transporter Family Member 4A1	Protein Coding	5.37	DISEASES inferred ¹⁵
5	SLC6A19	Solute Carrier Family 6 Member 19	Protein Coding	5.25	DISEASES inferred ¹⁵
6	SLC2A10	Solute Carrier Family 2 Member 10	Protein Coding	5.22	DISEASES inferred ¹⁵
7	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	5.15	DISEASES inferred ¹⁵
8	ERF	ETS2 Repressor Factor	Protein Coding	4.92	DISEASES inferred ¹⁵
9	KDM4D	Lysine Demethylase 4D	Protein Coding	4.91	DISEASES inferred ¹⁵
10	PTGER3	Prostaglandin E Receptor 3	Protein Coding	4.83	DISEASES inferred ¹⁵
11	PTGES	Prostaglandin E Synthase	Protein Coding	4.74	DISEASES inferred ¹⁵

Sources

Variations for Primary Hypertrophic Osteoarthropathy

ClinVar genetic disease variations for Primary Hypertrophic Osteoarthropathy:

⁶ (show top 50) (show all 97)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	HPGD	NM_000860.6(HPGD):c.232_241delinsCA (p.Val78fs)	Indel	Pathogenic	7918	rs587776676	GRCh37: 4:175439205-175439214 GRCh38: 4:174518054-174518063
2	HPGD	NM_000860.6(HPGD):c.173_174CT[1] (p.Leu59fs)	Microsatellite	Pathogenic	7919	rs548208942	GRCh37: 4:175443136-175443137 GRCh38: 4:174521985-174521986
3	SLCO2A1	NM_005630.3(SLCO2A1):c.97-1G>A	SNV	Pathogenic	30186	rs1559943990	GRCh37: 3:133698463-133698463 GRCh38: 3:133979619-133979619
4	SLCO2A1	NM_005630.3(SLCO2A1):c.764G>A (p.Gly255Glu)	SNV	Pathogenic	30187	rs387906806	GRCh37: 3:133670149-133670149 GRCh38: 3:133951305-133951305
5	SLCO2A1	NM_005630.3(SLCO2A1):c.1634del (p.Asn545fs)	Deletion	Pathogenic	30188	rs1559927542	GRCh37: 3:133657329-133657329 GRCh38: 3:133938485-133938485
6	SLCO2A1	NM_005630.3(SLCO2A1):c.830dup (p.Phe278fs)	Duplication	Pathogenic	37167	rs751192029	GRCh37: 3:133670082-133670083 GRCh38: 3:133951238-133951239
7	SLCO2A1	NM_005630.3(SLCO2A1):c.1259G>T (p.Cys420Phe)	SNV	Pathogenic	37169	rs387907295	GRCh37: 3:133666136-133666136 GRCh38: 3:133947292-133947292
8	SLCO2A1	NM_005630.3(SLCO2A1):c.253A>T (p.Ile85Phe)	SNV	Pathogenic	37170	rs387907296	GRCh37: 3:133692651-133692651 GRCh38: 3:133973807-133973807
9	SLCO2A1	NM_005630.3(SLCO2A1):c.310G>T (p.Gly104Ter)	SNV	Pathogenic	37171	rs387907297	GRCh37: 3:133692594-133692594 GRCh38: 3:133973750-133973750
10	HPGD	NM_000860.6(HPGD):c.418G>C (p.Ala140Pro)	SNV	Pathogenic	7917	rs121434480	GRCh37: 4:175429850-175429850 GRCh38: 4:174508699-174508699
11	HPGD	NM_000860.6(HPGD):c.1A>T (p.Met1Leu)	SNV	Pathogenic	156026	rs577045722	GRCh37: 4:175443602-175443602 GRCh38: 4:174522451-174522451
12	HPGD	NM_000860.6(HPGD):c.308_309CT[1] (p.Leu104fs)	Microsatellite	Pathogenic	156027	rs587777719	GRCh37: 4:175439135-175439136 GRCh38: 4:174517984-174517985
13	SLCO2A1	NM_005630.3(SLCO2A1):c.664G>A (p.Gly222Arg)	SNV	Pathogenic	438675	rs774795340	GRCh37: 3:133672567-133672567 GRCh38: 3:133953723-133953723
14	HPGD	NM_000860.6(HPGD):c.34G>A (p.Gly12Ser)	SNV	Pathogenic	973741		GRCh37: 4:175443569-175443569 GRCh38: 4:174522418-174522418
15	HPGD	NM_000860.6(HPGD):c.313C>T (p.Gln105Ter)	SNV	Pathogenic	973742		GRCh37: 4:175439133-175439133 GRCh38: 4:174517982-174517982
16	SLCO2A1	NM_005630.3(SLCO2A1):c.1807C>T (p.Arg603Ter)	SNV	Pathogenic	225477	rs776813259	GRCh37: 3:133654625-133654625 GRCh38: 3:133935781-133935781
17	SLCO2A1	NM_005630.3(SLCO2A1):c.940+1G>A	SNV	Pathogenic	225478	rs765249238	GRCh37: 3:133667736-133667736 GRCh38: 3:133948892-133948892
18	SLCO2A1	NM_005630.3(SLCO2A1):c.830del (p.Phe277fs)	Deletion	Pathogenic	977938		GRCh37: 3:133670083-133670083 GRCh38: 3:133951239-133951239
19	HPGD	NM_000860.6(HPGD):c.307del (p.Thr103fs)	Deletion	Pathogenic	1032480		GRCh37: 4:175439139-175439139 GRCh38: 4:174517988-174517988
20	SLCO2A1	NM_005630.3(SLCO2A1):c.1931G>C (p.Ter644Ser)	SNV	Pathogenic	1033018		GRCh37: 3:133653558-133653558 GRCh38: 3:133934714-133934714
21	SLCO2A1	NM_005630.3(SLCO2A1):c.290G>A (p.Arg97His)	SNV	Likely pathogenic	931465		GRCh37: 3:133692614-133692614 GRCh38: 3:133973770-133973770
22	SLCO2A1	NM_005630.3(SLCO2A1):c.547G>A (p.Gly183Arg)	SNV	Likely pathogenic	977939		GRCh37: 3:133673888-133673888 GRCh38: 3:133955044-133955044
23	SLCO2A1	NM_005630.3(SLCO2A1):c.1279_1290del (p.Glu427_Pro430del)	Deletion	Likely pathogenic	225479	rs1085307096	GRCh37: 3:133666105-133666116 GRCh38: 3:133947261-133947272
24	SLCO2A1	NM_005630.3(SLCO2A1):c.1524del (p.Val509fs)	Deletion	Likely pathogenic	977936		GRCh37: 3:133661550-133661550 GRCh38: 3:133942706-133942706
25	HPGD	NM_000860.6(HPGD):c.446C>G (p.Pro149Arg)	SNV	Likely pathogenic	599096	rs375335006	GRCh37: 4:175416751-175416751 GRCh38: 4:174495600-174495600
26	SLCO2A1	NM_005630.3(SLCO2A1):c.86del (p.Gly29fs)	Deletion	Likely pathogenic	829873	rs1576467025	GRCh37: 3:133748561-133748561 GRCh38: 3:134029717-134029717
27	SLCO2A1	NM_005630.3(SLCO2A1):c.1106-1G>C	SNV	Likely pathogenic	829878	rs1576428882	GRCh37: 3:133666290-133666290 GRCh38: 3:133947446-133947446
28	HPGD	NM_000860.6(HPGD):c.*1594A>G	SNV	Uncertain significance	899800		GRCh37: 4:175411513-175411513 GRCh38: 4:174490362-174490362
29	HPGD	NM_000860.6(HPGD):c.*819T>C	SNV	Uncertain significance	899858		GRCh37: 4:175412288-175412288 GRCh38: 4:174491137-174491137
30	HPGD	NM_000860.6(HPGD):c.397A>G (p.Ile133Val)	SNV	Uncertain significance	900187		GRCh37: 4:175429871-175429871 GRCh38: 4:174508720-174508720
31	HPGD	NM_000860.6(HPGD):c.*1450C>T	SNV	Uncertain significance	900962		GRCh37: 4:175411657-175411657 GRCh38: 4:174490506-174490506
32	HPGD	NM_000860.6(HPGD):c.*709A>C	SNV	Uncertain significance	899859		GRCh37: 4:175412398-175412398 GRCh38: 4:174491247-174491247
33	HPGD	NM_000860.6(HPGD):c.*648A>T	SNV	Uncertain significance	901032		GRCh37: 4:175412459-175412459 GRCh38: 4:174491308-174491308
34	HPGD	NM_000860.6(HPGD):c.*41A>G	SNV	Uncertain significance	899919		GRCh37: 4:175413066-175413066 GRCh38: 4:174491915-174491915
35	HPGD	NM_000860.6(HPGD):c.721G>A (p.Ala241Thr)	SNV	Uncertain significance	901092		GRCh37: 4:175413187-175413187 GRCh38: 4:174492036-174492036
36	HPGD	NM_000860.6(HPGD):c.*451A>G	SNV	Uncertain significance	901586		GRCh37: 4:175412656-175412656 GRCh38: 4:174491505-174491505
37	HPGD	NM_000860.6(HPGD):c.606A>G (p.Gln202=)	SNV	Uncertain significance	796877	rs374385011	GRCh37: 4:175414358-175414358 GRCh38: 4:174493207-174493207
38	HPGD	NM_000860.6(HPGD):c.501G>T (p.Leu167Phe)	SNV	Uncertain significance	901640		GRCh37: 4:175414463-175414463 GRCh38: 4:174493312-174493312
39	SLCO2A1	NM_005630.3(SLCO2A1):c.1333C>T (p.Arg445Cys)	SNV	Uncertain significance	774302	rs146970901	GRCh37: 3:133664067-133664067 GRCh38: 3:133945223-133945223
40	HPGD	NM_000860.6(HPGD):c.*1556C>T	SNV	Uncertain significance	348173	rs886059244	GRCh37: 4:175411551-175411551 GRCh38: 4:174490400-174490400
41	HPGD	NM_001256301.1(HPGD):c.-319G>A	SNV	Uncertain significance	348209	rs116796476	GRCh37: 4:175443823-175443823 GRCh38: 4:174522672-174522672
42	HPGD	NM_000860.6(HPGD):c.*248A>G	SNV	Uncertain significance	348192	rs886059251	GRCh37: 4:175412859-175412859 GRCh38: 4:174491708-174491708
43	HPGD	NM_000860.6(HPGD):c.*941C>T	SNV	Uncertain significance	348183	rs886059247	GRCh37: 4:175412166-175412166 GRCh38: 4:174491015-174491015
44	HPGD	NM_000860.6(HPGD):c.*510G>C	SNV	Uncertain significance	348190	rs886059250	GRCh37: 4:175412597-175412597 GRCh38: 4:174491446-174491446
45	HPGD	NM_001256301.1(HPGD):c.-400C>T	SNV	Uncertain significance	348211	rs145977377	GRCh37: 4:175443904-175443904 GRCh38: 4:174522753-174522753
46	HPGD	NM_000860.6(HPGD):c.*157A>G	SNV	Uncertain significance	348194	rs886059252	GRCh37: 4:175412950-175412950 GRCh38: 4:174491799-174491799
47	HPGD	NM_000860.6(HPGD):c.*914A>G	SNV	Uncertain significance	348184	rs886059248	GRCh37: 4:175412193-175412193 GRCh38: 4:174491042-174491042
48	HPGD	NM_001256301.1(HPGD):c.-271+17T>C	SNV	Uncertain significance	348207	rs552078994	GRCh37: 4:175443758-175443758 GRCh38: 4:174522607-174522607
49	HPGD	NM_000860.6(HPGD):c.773C>A (p.Thr258Lys)	SNV	Uncertain significance	348199	rs886059254	GRCh37: 4:175413135-175413135 GRCh38: 4:174491984-174491984
50	HPGD	NM_000860.6(HPGD):c.*968T>C	SNV	Uncertain significance	348182	rs530460934	GRCh37: 4:175412139-175412139 GRCh38: 4:174490988-174490988

Sources

Expression for Primary Hypertrophic Osteoarthropathy

Search GEO for disease gene expression data for Primary Hypertrophic Osteoarthropathy.

Sources

Pathways for Primary Hypertrophic Osteoarthropathy

Pathways related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds ⁶⁵ Show member pathways Bicarbonate transporters ⁶⁵ Cation-coupled Chloride cotransporters ⁶⁵ Class II GLUTs ⁶⁵ Facilitative Na+-independent glucose transporters ⁶⁵ Inositol transporters ⁶⁵ Multifunctional anion exchangers ⁶⁵ Na+/Cl- dependent neurotransmitter transporters ⁶⁵ Na+-dependent glucose transporters ⁶⁵ Organic anion transport ⁶⁵ Organic anion transporters ⁶⁵ Organic cation transport ⁶⁵ Organic cation/anion/zwitterion transport ⁶⁵ Proton/oligopeptide cotransporters ⁶⁵ Proton-coupled monocarboxylate transport ⁶⁵ Rhesus glycoproteins mediate ammonium transport. ⁶⁵ SLC-mediated transmembrane transport ⁶⁵ Sodium/Calcium exchangers ⁶⁵ Sodium/Proton exchangers ⁶⁵ Sodium-coupled phosphate cotransporters ⁶⁵ Sodium-coupled sulphate, di- and tri-carboxylate transporters ⁶⁵ Transmembrane transport of small molecules ⁶⁵ Transport of inorganic cations/anions and amino acids/oligopeptides ⁶⁵ Type II Na+/Pi cotransporters ⁶⁵	12.56	SLCO4A1 SLCO3A1 SLCO2A1 SLC6A19 SLC2A10 SLC17A5
2	Celecoxib Pathway, Pharmacodynamics ⁶⁰	11.13	PTGES PTGER3
3	Prostaglandin Synthesis and Regulation ¹	10.8	PTGER3 HPGD
4	Ibuprofen Pathway, Pharmacodynamics ⁶⁰	10.7	PTGES PTGER3
5	Transport of vitamins, nucleosides, and related molecules ⁶⁵ Show member pathways Transport of fatty acids ⁶⁵ Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane ⁶⁵ Transport of nucleotide sugars ⁶⁵ Transport of organic anions ⁶⁵	10.69	SLCO4A1 SLCO3A1 SLCO2A1
6	Prostaglandin 2 biosynthesis and metabolism FM ²³	10.52	PTGES HPGD

Sources

GO Terms for Primary Hypertrophic Osteoarthropathy

Cellular components related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of membrane	GO:0016021	9.56	SLCO4A1 SLCO3A1 SLCO2A1 SLC6A19 SLC2A10 SLC17A5
2	integral component of plasma membrane	GO:0005887	9.17	SLCO4A1 SLCO3A1 SLCO2A1 SLC6A19 SLC2A10 SLC17A5

Biological processes related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ion transport	GO:0006811	9.62	SLCO4A1 SLCO3A1 SLCO2A1 SLC17A5
2	transmembrane transport	GO:0055085	9.43	SLCO4A1 SLCO3A1 SLCO2A1 SLC6A19 SLC2A10 SLC17A5
3	amino acid transport	GO:0006865	9.37	SLC6A19 SLC17A5
4	prostaglandin metabolic process	GO:0006693	9.26	PTGES HPGD
5	prostaglandin transport	GO:0015732	9.16	SLCO3A1 SLCO2A1
6	sodium-independent organic anion transport	GO:0043252	8.8	SLCO4A1 SLCO3A1 SLCO2A1

Molecular functions related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transporter activity	GO:0022857	9.46	SLCO4A1 SLCO2A1 SLC2A10 SLC17A5
2	prostaglandin E receptor activity	GO:0004957	9.26	PTGER3 HPGD
3	carbohydrate:proton symporter activity	GO:0005351	8.96	SLC2A10 SLC17A5
4	sodium-independent organic anion transmembrane transporter activity	GO:0015347	8.8	SLCO4A1 SLCO3A1 SLCO2A1

Sources

Sources for Primary Hypertrophic Osteoarthropathy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Primary Hypertrophic Osteoarthropathy (PDP)

Aliases & Classifications for Primary Hypertrophic Osteoarthropathy

MalaCards integrated aliases for Primary Hypertrophic Osteoarthropathy:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Primary Hypertrophic Osteoarthropathy

Related Diseases for Primary Hypertrophic Osteoarthropathy

Diseases in the Primary Hypertrophic Osteoarthropathy family:

Diseases related to Primary Hypertrophic Osteoarthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Primary Hypertrophic Osteoarthropathy:

Symptoms & Phenotypes for Primary Hypertrophic Osteoarthropathy

Human phenotypes related to Primary Hypertrophic Osteoarthropathy:

UMLS symptoms related to Primary Hypertrophic Osteoarthropathy:

GenomeRNAi Phenotypes related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Primary Hypertrophic Osteoarthropathy:

Drugs & Therapeutics for Primary Hypertrophic Osteoarthropathy

Drugs for Primary Hypertrophic Osteoarthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: osteoarthropathy, primary hypertrophic

Genetic Tests for Primary Hypertrophic Osteoarthropathy

Genetic tests related to Primary Hypertrophic Osteoarthropathy:

Anatomical Context for Primary Hypertrophic Osteoarthropathy

MalaCards organs/tissues related to Primary Hypertrophic Osteoarthropathy:

Publications for Primary Hypertrophic Osteoarthropathy

Articles related to Primary Hypertrophic Osteoarthropathy:

Genes for Primary Hypertrophic Osteoarthropathy

Genes related to Primary Hypertrophic Osteoarthropathy (2 elite genes):

Variations for Primary Hypertrophic Osteoarthropathy

ClinVar genetic disease variations for Primary Hypertrophic Osteoarthropathy:

Expression for Primary Hypertrophic Osteoarthropathy

Pathways for Primary Hypertrophic Osteoarthropathy

Pathways related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

GO Terms for Primary Hypertrophic Osteoarthropathy

Cellular components related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

Biological processes related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

Molecular functions related to Primary Hypertrophic Osteoarthropathy according to GeneCards Suite gene sharing:

Sources for Primary Hypertrophic Osteoarthropathy