MCID: PRM293
MIFTS: 35

Primary Mediastinal B-Cell Lymphoma

Categories: Cancer diseases, Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Primary Mediastinal B-Cell Lymphoma

MalaCards integrated aliases for Primary Mediastinal B-Cell Lymphoma:

Name: Primary Mediastinal B-Cell Lymphoma 12
Mediastinal Diffuse Large-Cell Lymphoma with Sclerosis 12
Primary Mediastinal Clear Cell Lymphoma of B-Cell Type 12
Large Cell Lymphoma of the Mediastinum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080210
ICD10 33 C85.2

Summaries for Primary Mediastinal B-Cell Lymphoma

Disease Ontology : 12 A diffuse large B-cell lymphoma that is is characterized by a diffuse proliferation of medium to large B-cells associated with sclerosis.

MalaCards based summary : Primary Mediastinal B-Cell Lymphoma, also known as mediastinal diffuse large-cell lymphoma with sclerosis, is related to primary mediastinal large b-cell lymphoma and b-cell lymphomas. An important gene associated with Primary Mediastinal B-Cell Lymphoma is BCL6 (B Cell CLL/Lymphoma 6), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Interleukin-4 and 13 signaling. The drugs Cyclophosphamide and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include b cells and t cells, and related phenotype is homeostasis/metabolism.

Related Diseases for Primary Mediastinal B-Cell Lymphoma

Diseases in the Primary Mediastinal B-Cell Lymphoma family:

Primary Mediastinal Large B-Cell Lymphoma

Diseases related to Primary Mediastinal B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 primary mediastinal large b-cell lymphoma 31.8 BCL6 STAT6
2 b-cell lymphomas 29.7 BCL6 REL
3 diffuse large b-cell lymphoma 29.0 BCL6 REL
4 lymphoma 10.7
5 mediastinitis 10.7
6 lymphoma, hodgkin, classic 10.2
7 gray zone lymphoma 10.1
8 mediastinal gray zone lymphoma 10.0
9 follicular lymphoma 9.9
10 leukemia 9.9
11 neutropenia 9.9
12 t-cell leukemia 9.9
13 t-cell/histiocyte rich large b cell lymphoma 9.9 BCL6 SLC22A2
14 mediastinal malignant lymphoma 9.4 BCL6 REL

Graphical network of the top 20 diseases related to Primary Mediastinal B-Cell Lymphoma:



Diseases related to Primary Mediastinal B-Cell Lymphoma

Symptoms & Phenotypes for Primary Mediastinal B-Cell Lymphoma

MGI Mouse Phenotypes related to Primary Mediastinal B-Cell Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 BCL6 PTPN1 REL SLC22A2 STAT6

Drugs & Therapeutics for Primary Mediastinal B-Cell Lymphoma

Drugs for Primary Mediastinal B-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
2
Cytarabine Approved, Investigational Phase 2,Not Applicable 147-94-4 6253
3
Doxorubicin Approved, Investigational Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
4
Etoposide Approved Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
5
Lenograstim Approved, Investigational Phase 2,Not Applicable 135968-09-1
6
Methylprednisolone Approved, Vet_approved Phase 2,Not Applicable 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 2,Not Applicable 50-24-8 5755
8
rituximab Approved Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
9
Vincristine Approved, Investigational Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
10
Ifosfamide Approved Phase 2,Not Applicable 3778-73-2 3690
11
Mechlorethamine Approved, Investigational Phase 2,Not Applicable 51-75-2 4033
12
Methotrexate Approved Phase 2,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
13
Prednisone Approved, Vet_approved Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
14
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
15
Melphalan Approved Phase 2 148-82-3 4053 460612
16
Pembrolizumab Approved Phase 2,Phase 1 1374853-91-4
17
Fludarabine Approved Phase 1, Phase 2,Phase 2 21679-14-1, 75607-67-9 30751
18
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
19
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
20
Obinutuzumab Approved, Investigational Phase 2 949142-50-1
21
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
22
leucovorin Approved, Nutraceutical Phase 2,Not Applicable,Early Phase 1 58-05-9 143 6006
23
Doxil Approved June 1999 Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
24 Antiemetics Phase 2,Not Applicable
25 Anti-Inflammatory Agents Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Autonomic Agents Phase 2,Not Applicable
27 Etoposide phosphate Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Gastrointestinal Agents Phase 2,Not Applicable
29 glucocorticoids Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Hormone Antagonists Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Hormones Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Methylprednisolone acetate Phase 2,Not Applicable
34 Methylprednisolone Hemisuccinate Phase 2,Not Applicable
35 Neuroprotective Agents Phase 2,Not Applicable
36 Peripheral Nervous System Agents Phase 2,Not Applicable
37 Prednisolone acetate Phase 2,Not Applicable
38 Prednisolone hemisuccinate Phase 2,Not Applicable
39 Prednisolone phosphate Phase 2,Not Applicable
40 Protective Agents Phase 2,Not Applicable
41 Alkylating Agents Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Antineoplastic Agents, Alkylating Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Antirheumatic Agents Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Antineoplastic Agents, Phytogenic Phase 2,Phase 1,Not Applicable,Early Phase 1
45
Isophosphamide mustard Phase 2,Not Applicable 0
46 Topoisomerase Inhibitors Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
48 Antimetabolites Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Antimetabolites, Antineoplastic Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Antiviral Agents Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 R-MegaCHOP-ESHAP-BEAM in Patients With High-Risk Aggressive B-Cell Lymphomas Completed NCT00558220 Phase 2
2 Study of Ibrutinib in Combination With Bendamustine and Rituximab for Patients With Relapsed/Refractory Aggressive BCL Recruiting NCT02747732 Phase 2 Bendamustine 90 mg/m2 IV on Days 1-2, Cycles 1-6
3 Pembrolizumab and Fractionated External Beam Radiotherapy (EBRT) in Patients With Non-Hodgkin Lymphoma (NHL) Recruiting NCT03210662 Phase 2 Pembrolizumab
4 A Phase 1-2 Multi-Center Study Evaluating Axicabtagene Ciloleucel in Subjects With Refractory Aggressive Non-Hodgkin Lymphoma (ZUMA-1) Recruiting NCT02348216 Phase 1, Phase 2
5 Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL Recruiting NCT02393157 Phase 2 Obinutuzumab;Liposomal ARA-C;Ifosfamide;Carboplatin;Etoposide
6 Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma Recruiting NCT00001337 Phase 2 EPOCH
7 Treatment for Advanced B-Cell Lymphoma Recruiting NCT01859819 Phase 2 Rituximab;IT Cytarabine
8 Ibrutinib and Lenalidomide With Dose Adjusted EPOCH-R in Subjects With Relapsed/Refractory Diffuse Large B-cell Lymphoma Active, not recruiting NCT02142049 Phase 1, Phase 2 Ibrutinib;Part 1: Dose Level 1
9 Copanlisib and Nivolumab in Treating Participants With Recurrent or Refractory Diffuse Large B-cell Lymphoma or Primary Mediastinal Large B-cell Lymphoma Not yet recruiting NCT03484819 Phase 2 Copanlisib
10 T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas Recruiting NCT03049449 Phase 1 Cyclophosphamide;Fludarabine
11 Study Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (TRANSCEND-NHL-001) Recruiting NCT02631044 Phase 1
12 CAR T Cell Receptor Immunotherapy for Patients With B-cell Lymphoma Active, not recruiting NCT00924326 Phase 1 Fludarabine;Cyclophosphamide
13 A Trial of Pembrolizumab (MK-3475) in Participants With Blood Cancers (MK-3475-013/KEYNOTE-013) Active, not recruiting NCT01953692 Phase 1 Lenalidomide
14 Combination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymphoma Unknown status NCT00689845 Not Applicable cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide phosphate;ifosfamide;methotrexate;prednisolone;prednisone;vincristine sulfate;vindesine
15 A Clinico-Pathologic Study of Primary Mediastinal B-Cell Lymphoma Completed NCT00944567
16 Mediastinal Grey Zone Lymphoma From the LYSA Completed NCT03037177
17 Dose Adjusted EPOCH-R, to Treat Mature B Cell Malignancies Completed NCT01760226 Early Phase 1 DA-EPOCH-R for DLBCL, PTLD, AND PMBCL;Methotrexate;Etoposide;Doxorubicin;Vincristine;Rituximab;Cyclophosphamide;Prednisone;G-CSF
18 Randomized, Open-label, Two-arms, Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma Recruiting NCT01599559 Not Applicable
19 Axicabtagene Ciloleucel Expanded Access Study Available NCT03153462

Search NIH Clinical Center for Primary Mediastinal B-Cell Lymphoma

Genetic Tests for Primary Mediastinal B-Cell Lymphoma

Anatomical Context for Primary Mediastinal B-Cell Lymphoma

MalaCards organs/tissues related to Primary Mediastinal B-Cell Lymphoma:

41
B Cells, T Cells

Publications for Primary Mediastinal B-Cell Lymphoma

Articles related to Primary Mediastinal B-Cell Lymphoma:

(show top 50) (show all 51)
# Title Authors Year
1
Autologous stem cell transplantation for primary mediastinal B-cell lymphoma: long-term outcome and role of post-transplant radiotherapy. A report of the European Society for Blood and Marrow Transplantation. ( 29463854 )
2018
2
End-of-treatment and serial PET imaging in primary mediastinal B-cell lymphoma following dose-adjusted-EPOCH-R: A paradigm shift in clinical decision making. ( 29748435 )
2018
3
Metabolic heterogeneity on baseline 18FDG-PET/CT scan is a predictor of outcome in primary mediastinal B-cell lymphoma. ( 29720487 )
2018
4
What is the standard of care for primary mediastinal B cell lymphoma; R-CHOP or DA-EPOCH-R? - Response to Melani etA al. ( 29528099 )
2018
5
STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma. ( 29501729 )
2018
6
Lactate dehydrogenase levels and 18F-FDG PET/CT metrics differentiate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma. ( 29672465 )
2018
7
Ruxolitinib significantly enhances <i>in vitro</i> apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model. ( 29515770 )
2018
8
A study of the dosimetric characteristics between different fixed-field IMRT and VMAT in early-stage primary mediastinal B-cell lymphoma. ( 28935521 )
2018
9
Management of Primary Mediastinal B-Cell Lymphoma in Pregnancy. ( 29686956 )
2018
10
R-CHOP versus dose-adjusted R-EPOCH in frontline management of primary mediastinal B-cell lymphoma: a multi-centre analysis. ( 29265182 )
2018
11
What is the standard of care for primary mediastinal b-cell lymphoma; R-CHOP or DA-EPOCH-R? ( 29532904 )
2018
12
How I treat primary mediastinal B-cell lymphoma. ( 29976557 )
2018
13
Combined PD-1 and JAK1/2 inhibition in refractory primary mediastinal B-cell lymphoma. ( 29327077 )
2018
14
Outcomes of adults and children with primary mediastinal B-cell lymphoma treated with dose-adjusted EPOCH-R. ( 29082519 )
2017
15
Second cancer incidence in primary mediastinal B-cell lymphoma treated with methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin regimen with or without rituximab and mediastinal radiotherapy: Results from a monoinstitutional cohort analysis of long-term survivors. ( 28078727 )
2017
16
High-grade neutropenia in a patient successfully treated with nivolumab for refractory primary mediastinal B-cell lymphoma. ( 29296772 )
2017
17
Primary mediastinal B-cell lymphoma: biology and evolving therapeutic strategies. ( 29222270 )
2017
18
Addition of rituximab to CHOP-like chemotherapy in first line treatment of primary mediastinal B-cell lymphoma. ( 28532396 )
2017
19
Management of Primary Mediastinal B-Cell Lymphoma and Gray Zone Lymphoma. ( 28620906 )
2017
20
Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma. ( 27312795 )
2016
21
Prognostic Role of Pre-Radiation Therapy (18)F-Fluorodeoxyglucose Positron Emission Tomography for Primary Mediastinal B-Cell Lymphomas Treated with R-CHOP or R-CHOP-Like Chemotherapy Plus Radiation. ( 27130796 )
2016
22
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. ( 27670424 )
2016
23
Optimizing Outcomes in Primary Mediastinal B-cell Lymphoma. ( 27888880 )
2016
24
Mediastinal Gray Zone Lymphoma with Features Intermediate between Classical Hodgkin Lymphoma and Primary Mediastinal B-Cell Lymphoma. ( 27623181 )
2016
25
Female fertility following dose-adjusted EPOCH-R chemotherapy in primary mediastinal B-cell lymphomas. ( 27183887 )
2016
26
Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? ( 25499450 )
2015
27
Malignant hematopoietic cell lines: in vitro models for the study of primary mediastinal B-cell lymphomas. ( 25480038 )
2015
28
Absence of BRAF and KRAS hotspot mutations in primary mediastinal B-cell lymphoma. ( 24397598 )
2014
29
KIT mutations in primary mediastinal B-cell lymphoma. ( 25148223 )
2014
30
FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma. ( 24977668 )
2014
31
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma. ( 24531327 )
2014
32
STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL). ( 23852366 )
2013
33
T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. ( 20382409 )
2010
34
Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma. ( 19423726 )
2009
35
Expression of Grb2 distinguishes classical Hodgkin lymphomas from primary mediastinal B-cell lymphomas and other diffuse large B-cell lymphomas. ( 19716163 )
2009
36
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. ( 19380639 )
2009
37
STAT6 activity is regulated by SOCS-1 and modulates BCL-XL expression in primary mediastinal B-cell lymphoma. ( 18401415 )
2008
38
Primary mediastinal B-cell lymphoma. ( 17575573 )
2007
39
Gains of REL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein. ( 17243160 )
2007
40
Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma. ( 17638864 )
2007
41
Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH). ( 17728785 )
2007
42
Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma. ( 16871282 )
2006
43
Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma. ( 15744341 )
2005
44
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. ( 15377470 )
2004
45
Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins. ( 12507907 )
2003
46
Pathobiology of primary mediastinal B-cell lymphoma. ( 15202521 )
2003
47
Superior vena cava syndrome and hypercalcaemia in a patient with a primary mediastinal B-cell lymphoma secreting parathyroid hormone-related protein. ( 12358896 )
2002
48
Alteration of chromosome arm 6p is characteristic of primary mediastinal B-cell lymphoma, as identified by genome-wide allelotyping. ( 11319807 )
2001
49
Pleomorphic large cell lymphomas of the mediastinum. ( 8554112 )
1996
50
Molecular characterization of primary mediastinal B cell lymphoma. ( 8669486 )
1996

Variations for Primary Mediastinal B-Cell Lymphoma

Cosmic variations for Primary Mediastinal B-Cell Lymphoma:

9
(show top 50) (show all 79)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM96797 XPO1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1711G>A p.E571K 2:61492337-61492337 3
2 COSM45892 TP53 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.857A>C p.E286A 17:7673763-7673763 3
3 COSM45652 TP53 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.914A>C p.K305T 17:7673706-7673706 3
4 COSM35925 TNFAIP3 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1004T>G p.L335* 6:137878449-137878449 3
5 COSM35928 TNFAIP3 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.2343A>T p.E781D 6:137881289-137881289 3
6 COSM35930 TNFAIP3 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.569C>A p.S190* 6:137875770-137875770 3
7 COSM6932498 SOX17 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.146C>T p.P49L 8:54458284-54458284 3
8 COSM6986929 SOCS1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.14A>T p.N5I 16:11255465-11255465 3
9 COSM6986928 SOCS1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.182A>T p.H61L 16:11255297-11255297 3
10 COSM6986927 SOCS1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.533G>A p.C178Y 16:11254946-11254946 3
11 COSM6932501 SOCS1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.274C>G p.R92G 16:11255205-11255205 3
12 COSM6932499 SOCS1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.550G>A p.A184T 16:11254929-11254929 3
13 COSM6936864 RAD50 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.2443A>G p.I815V 5:132609147-132609147 3
14 COSM6936879 RAB35 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.262T>G p.Y88D 12:120099120-120099120 3
15 COSM6932496 PIM1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.427C>A p.L143M 6:37171311-37171311 3
16 COSM6936865 PIM1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.202C>T p.H68Y 6:37170993-37170993 3
17 COSM1581454 PIK3CD haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.3061G>A p.E1021K 1:9726972-9726972 3
18 COSM6936881 PIK3C3 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.452C>T p.A151V 18:41970377-41970377 3
19 COSM6936872 PIK3C2G haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1175T>G p.L392R 12:18320999-18320999 3
20 COSM6936878 PIK3C2G haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.2366C>A p.A789D 12:18424024-18424024 3
21 COSM6936875 PIK3C2G haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.2105A>C p.D702A 12:18399760-18399760 3
22 COSM6929577 NTRK2 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1912C>T p.H638Y 9:84948609-84948609 3
23 COSM6932493 MYCN haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1178G>A p.R393H 2:15945880-15945880 3
24 COSM6929580 MRE11 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.757C>T p.P253S 11:94471662-94471662 3
25 COSM6936868 KMT2C haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.34C>T p.P12S 7:152435753-152435753 3
26 COSM12600 JAK2 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1849G>T p.V617F 9:5073770-5073770 3
27 COSM6936858 JAK1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1208T>G p.L403W 1:64860231-64860231 3
28 COSM3410849 HIST1H3F haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.191G>A p.R64H 6:26250415-26250415 3
29 COSM6932497 HGF haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1978G>T p.G660W 7:81705422-81705422 3
30 COSM6936880 FOXA1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1219T>C p.S407P 14:37591565-37591565 3
31 COSM6929573 FAT1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.8456T>C p.V2819A 4:186618130-186618130 3
32 COSM6932495 FAT1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.12674C>T p.T4225M 4:186596866-186596866 3
33 COSM6932494 FAT1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.12674C>T p.T4225M 4:186596866-186596866 3
34 COSM6929574 FAT1 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.8456T>C p.V2819A 4:186618130-186618130 3
35 COSM37028 EZH2 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1937A>T p.Y646F 7:148811635-148811635 3
36 COSM6936862 ERBB4 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.1904A>G p.Y635C 2:211657796-211657796 3
37 COSM231560 DNMT3A haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.2206C>T p.R736C 2:25240418-25240418 3
38 COSM6986923 CDKN2B haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.68C>G p.A23G 9:22008886-22008886 3
39 COSM12475 CDKN2A haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.238C>T p.R80* 9:21971121-21971121 3
40 COSM6929581 CDKN1B haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.322G>A p.D108N 12:12718161-12718161 3
41 COSM6929588 BCL2 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.40A>C p.I14L 18:63318627-63318627 3
42 COSM4170969 BCL2 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.4G>C p.A2P 18:63318663-63318663 3
43 COSM144522 B2M haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.2T>A p.M1K 15:44711548-44711548 3
44 COSM5383384 B2M haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.67+2T>C p.? 15:44711615-44711615 3
45 COSM6929579 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.757C>T p.P253S 11:94471662-94471662 3
46 COSM99935 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.404C>T p.P135L 9:21971121-21971121 3
47 COSM4243207 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.3133G>A p.E1045K 1:9726972-9726972 3
48 COSM99191 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.238C>T p.R80* 9:21971121-21971121 3
49 COSM3077774 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.295T>C p.C99R 6:394899-394899 3
50 COSM6936874 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,primary mediastinal B cell lymphoma c.2228A>C p.D743A 12:18399760-18399760 3

Copy number variations for Primary Mediastinal B-Cell Lymphoma from CNVD:

7 (show all 32)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16483 1 125000000 249250621 Gain Primary mediastinal b-cell lymphoma
2 37060 1 84900000 88400000 Amplification BCL10 Primary mediastinal b-cell lymphoma
3 37527 1 92000000 94700000 Amplification TGFBR3 Primary mediastinal b-cell lymphoma
4 49708 11 110400000 121200000 Gain Primary mediastinal b-cell lymphoma
5 57454 11 63400000 77100000 Gain Primary mediastinal b-cell lymphoma
6 58554 11 68400000 70400000 Loss FADD Primary mediastinal b-cell lymphoma
7 61549 12 1 35800000 Gain Primary mediastinal b-cell lymphoma
8 70078 12 58100000 67700000 Gain MDM2 Primary mediastinal b-cell lymphoma
9 77099 13 40100000 45200000 Loss Primary mediastinal b-cell lymphoma
10 88311 14 89800000 107349540 Loss Primary mediastinal b-cell lymphoma
11 89760 15 19000000 20700000 Loss Primary mediastinal b-cell lymphoma
12 106724 17 1 10700000 Loss ABR Primary mediastinal b-cell lymphoma
13 106727 17 1 10700000 Loss TUSC5 Primary mediastinal b-cell lymphoma
14 121464 18 43500000 61600000 Gain BCL2 Primary mediastinal b-cell lymphoma
15 121465 18 43500000 61600000 Gain MALT1 Primary mediastinal b-cell lymphoma
16 137935 2 154900000 169700000 Gain or amplification IL8RA Primary mediastinal b-cell lymphoma
17 137936 2 154900000 169700000 Gain or amplification IL8RB Primary mediastinal b-cell lymphoma
18 147240 2 61300000 64100000 Amplification REL Primary mediastinal b-cell lymphoma
19 147241 2 61300000 64100000 Gain or amplificatio n BCL11A Primary mediastinal b-cell lymphoma
20 157133 21 13200000 48129895 Gain Primary mediastinal b-cell lymphoma
21 172486 3 182700000 187900000 Gain BCL6 Primary mediastinal b-cell lymphoma
22 187516 4 50400000 191154276 Loss Primary mediastinal b-cell lymphoma
23 195325 5 15000000 18400000 Amplification Primary mediastinal b-cell lymphoma
24 211275 6 32548521 32557528 Loss Primary mediastinal b-cell lymphoma
25 228595 7 77500000 98000000 Amplification CDK6 Primary mediastinal b-cell lymphoma
26 230112 7 98000000 107400000 Gain Primary mediastinal b-cell lymphoma
27 233698 8 12700000 19000000 Loss Primary mediastinal b-cell lymphoma
28 233886 8 128753680 129113499 Gain MYC Primary mediastinal b-cell lymphoma
29 244977 9 1 9000000 Amplification PDL2 Primary mediastinal b-cell lymphoma
30 244983 9 1 9000000 Gain Primary mediastinal b-cell lymphoma
31 244986 9 1 9000000 Gain or amplificatio n JAK2 Primary mediastinal b-cell lymphoma
32 247560 9 130300000 141213431 Gain Primary mediastinal b-cell lymphoma

Expression for Primary Mediastinal B-Cell Lymphoma

Search GEO for disease gene expression data for Primary Mediastinal B-Cell Lymphoma.

Pathways for Primary Mediastinal B-Cell Lymphoma

Pathways related to Primary Mediastinal B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 BCL6 REL
2 11.43 BCL6 STAT6
3
Show member pathways
11.37 REL STAT6
4 11.31 BCL6 REL STAT6
5 11.06 BCL6 STAT6
6
Show member pathways
10.78 PTPN1 STAT6
7 10.56 PTPN1 STAT6

GO Terms for Primary Mediastinal B-Cell Lymphoma

Biological processes related to Primary Mediastinal B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.33 BCL6 REL STAT6
2 response to cytokine GO:0034097 8.96 REL STAT6
3 negative regulation of type 2 immune response GO:0002829 8.62 BCL6 STAT6

Molecular functions related to Primary Mediastinal B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 BCL6 REL STAT6
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.8 BCL6 REL STAT6

Sources for Primary Mediastinal B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....