MCID: PRM163
MIFTS: 45

Primary Mediastinal Large B-Cell Lymphoma

Categories: Cancer diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Primary Mediastinal Large B-Cell Lymphoma

MalaCards integrated aliases for Primary Mediastinal Large B-Cell Lymphoma:

Name: Primary Mediastinal Large B-Cell Lymphoma 59
Mediastinal Diffuse Large-Cell Lymphoma with Sclerosis 59
Primary Mediastinal Clear Cell Lymphoma of B-Cell Type 59
Large Cell Lymphoma of the Mediastinum 59
Mediastinal Large B-Cell Lymphoma 73
Med-Dlbcl 59

Characteristics:

Orphanet epidemiological data:

59
primary mediastinal large b-cell lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA98838
UMLS via Orphanet 74 C0855152 C1292754
ICD10 via Orphanet 34 C83.3
ICD10 33 C85.2
UMLS 73 C1292754

Summaries for Primary Mediastinal Large B-Cell Lymphoma

MalaCards based summary : Primary Mediastinal Large B-Cell Lymphoma, also known as mediastinal diffuse large-cell lymphoma with sclerosis, is related to primary mediastinal b-cell lymphoma and lymphoma, hodgkin, classic. An important gene associated with Primary Mediastinal Large B-Cell Lymphoma is BCL6 (B Cell CLL/Lymphoma 6), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Notch signaling pathway (KEGG). The drugs Sunitinib and rituximab have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and heart, and related phenotypes are cellular and hematopoietic system

Related Diseases for Primary Mediastinal Large B-Cell Lymphoma

Diseases in the Primary Mediastinal B-Cell Lymphoma family:

Primary Mediastinal Large B-Cell Lymphoma

Diseases related to Primary Mediastinal Large B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 primary mediastinal b-cell lymphoma 32.6 BCL6 STAT6
2 lymphoma, hodgkin, classic 30.0 BCL6 IRF4
3 diffuse large b-cell lymphoma 29.9 BCL6 FOXP1 IRF4
4 b-cell lymphomas 29.8 BCL2 BCL6 FOXP1 IRF4
5 lymphoma 11.0
6 mediastinitis 11.0
7 gray zone lymphoma 10.3
8 colon lymphoma 10.3 BCL6 IRF4
9 myasthenic syndrome, congenital, 14 10.3 CD274 JAK2
10 mediastinal gray zone lymphoma 10.2
11 primary effusion lymphoma 10.2 BCL6 IRF4
12 testicular lymphoma 10.2 BCL6 FOXP1
13 epstein-barr virus-associated gastric carcinoma 10.0 CD274 JAK2
14 hemopericardium 9.9
15 pericardial effusion 9.9
16 liposarcoma 9.9
17 thyroiditis 9.9
18 bone marrow necrosis 9.9
19 nodular lymphocyte predominant hodgkin lymphoma 9.9
20 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 9.9 BCL2 BCL6
21 nodal marginal zone b-cell lymphoma 9.9 BCL2 BCL6
22 follicular lymphoma 1 9.9 BCL2 BCL6
23 mediastinal malignant lymphoma 9.9 BCL6 CD274 XPO1
24 intravascular large b-cell lymphoma 9.8 BCL2 BCL6
25 primary central nervous system lymphoma 9.8 BCL2 BCL6
26 central nervous system lymphoma 9.8 BCL6 FOXP1
27 human herpesvirus 8 9.7 BCL2 BCL6
28 gastric lymphoma 9.7 BCL2 BCL6
29 marginal zone b-cell lymphoma 9.4 BCL2 BCL6 IRF4
30 follicular lymphoma 9.4 BCL2 BCL6 IRF4
31 lymphoma, non-hodgkin, familial 9.1 BCL2 BCL6 IRF4
32 lymphoma, mucosa-associated lymphoid type 8.8 BCL2 BCL6 FOXP1 IRF4

Graphical network of the top 20 diseases related to Primary Mediastinal Large B-Cell Lymphoma:



Diseases related to Primary Mediastinal Large B-Cell Lymphoma

Symptoms & Phenotypes for Primary Mediastinal Large B-Cell Lymphoma

MGI Mouse Phenotypes related to Primary Mediastinal Large B-Cell Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 BCL6 CD274 IRF4 JAK2 STAT6 BCL2
2 hematopoietic system MP:0005397 9.63 BCL2 BCL6 CD274 IRF4 JAK2 STAT6
3 immune system MP:0005387 9.43 BCL2 BCL6 CD274 IRF4 JAK2 STAT6
4 neoplasm MP:0002006 8.92 BCL2 IRF4 JAK2 STAT6

Drugs & Therapeutics for Primary Mediastinal Large B-Cell Lymphoma

Drugs for Primary Mediastinal Large B-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
2
rituximab Approved Phase 2,Not Applicable 174722-31-7 10201696
3
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
4
Doxorubicin Approved, Investigational Phase 1, Phase 2,Phase 2 23214-92-8 31703
5
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
6
Vinorelbine Approved, Investigational Phase 1, Phase 2 71486-22-1 60780 44424639
7
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
8
nivolumab Approved Phase 1, Phase 2 946414-94-4
9
Azacitidine Approved, Investigational Phase 1, Phase 2 320-67-2 9444
10
Decitabine Approved, Investigational Phase 1, Phase 2 2353-33-5 451668
11
Etoposide Approved Phase 2 33419-42-0 36462
12
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
13
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
14
Pembrolizumab Approved Phase 2,Phase 1 1374853-91-4
15
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
16
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
17
Doxil Approved June 1999 Phase 1, Phase 2,Phase 2 31703
18 Angiogenesis Inhibitors Phase 2,Phase 1
19 Angiogenesis Modulating Agents Phase 2,Phase 1
20 Antibodies Phase 2,Phase 1
21 Immunoglobulins Phase 2,Phase 1
22 Antibodies, Monoclonal Phase 2,Phase 1
23 Prednisolone acetate Phase 1, Phase 2
24 glucocorticoids Phase 1, Phase 2,Phase 2
25 Methylprednisolone acetate Phase 1, Phase 2
26 Methylprednisolone Hemisuccinate Phase 1, Phase 2
27 Gastrointestinal Agents Phase 1, Phase 2
28 Neuroprotective Agents Phase 1, Phase 2
29 Hormone Antagonists Phase 1, Phase 2,Phase 2
30 Hormones Phase 1, Phase 2,Phase 2
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2,Phase 2
32 Peripheral Nervous System Agents Phase 1, Phase 2
33 Prednisolone hemisuccinate Phase 1, Phase 2
34 Prednisolone phosphate Phase 1, Phase 2
35 Antiemetics Phase 1, Phase 2
36 Protective Agents Phase 1, Phase 2
37 Anti-Inflammatory Agents Phase 1, Phase 2,Phase 2
38 Antirheumatic Agents Phase 2,Not Applicable
39 Antimetabolites Phase 1, Phase 2
40 Autonomic Agents Phase 1, Phase 2
41 Antimetabolites, Antineoplastic Phase 1, Phase 2
42 Antineoplastic Agents, Hormonal Phase 1, Phase 2,Phase 2
43 Alkylating Agents Phase 2
44 Topoisomerase Inhibitors Phase 2
45 Anti-Bacterial Agents Phase 2
46 Antibiotics, Antitubercular Phase 2
47 Etoposide phosphate Phase 2
48 Immunosuppressive Agents Phase 2
49 Antimitotic Agents Phase 2
50 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Pilot Study of Ruxolitinib in Relapsed or Refractory Hodgkin Lymphoma and Primary Mediastinal Large B-cell Lymphoma Completed NCT01965119 Phase 2 Ruxolitinib
2 A Study of SGN-35 (Brentuximab Vedotin) of Patients With Relapsed or Refractory PMLBCL Completed NCT02423291 Phase 2 Brentuximab Vedotin
3 Sunitinib in Treating Patients With Relapsed or Refractory Diffuse or Mediastinal Large B-Cell Lymphoma Completed NCT00392496 Phase 2 sunitinib malate
4 CT-011 MAb in DLBCL Patients Following ASCT Completed NCT00532259 Phase 2 CT-011
5 Combination of Chemotherapy, SHR-1210 and/or Decitabine for Relapsed/Refractory PMBCLs Recruiting NCT03346642 Phase 1, Phase 2 Decitabine;GVD chemotherapy;SHR-1210
6 An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas Recruiting NCT02581631 Phase 1, Phase 2 Brentuximab Vedotin
7 Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma Recruiting NCT00001337 Phase 2 EPOCH
8 Open-Label, Multicenter, Phase 1/2 Study of Tazemetostat (EZH2 Histone Methyl Transferase [HMT] Inhibitor) as a Single Agent in Subjects With Adv. Solid Tumors or With B-cell Lymphomas and Tazemetostat in Combination With Prednisolone in Subjects With DLB Recruiting NCT01897571 Phase 1, Phase 2 Tazemetostat
9 Study of Pembrolizumab (MK-3475) in Participants With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma or Relapsed or Refractory Richter Syndrome (MK-3475-170/KEYNOTE-170) Active, not recruiting NCT02576990 Phase 2
10 Intergroup Trial for Children or Adolescents With Primary Mediastinal Large B-Cell Lymphoma: DA-EPOCH-Rituximab Evaluation Active, not recruiting NCT01516567 Phase 2 Etoposide, Doxorubicin, Vincristine, Cyclophosphamide, Rituximab
11 A Phase I/II Study Of Brentuximab Vedotin In Combination With Multi-Agent Chemotherapy As Front-Line Treatment In Patients With CD30 Positive Primary Mediastinal Large B-Cell, Diffuse Large B-Cell, And Grey Zone Lymphomas Active, not recruiting NCT01994850 Phase 1, Phase 2 brentuximab vedotin
12 Copanlisib and Nivolumab in Treating Participants With Recurrent or Refractory Diffuse Large B-cell Lymphoma or Primary Mediastinal Large B-cell Lymphoma Not yet recruiting NCT03484819 Phase 2 Copanlisib
13 Ph II CHOP+Velcade in Mediastinal LBCL Terminated NCT00361621 Phase 2 bortezomib;Rituximab;Cyclophosphamide;Doxorubicin;Vincristine;Prednisone
14 Rituximab and Combination Chemotherapy With or Without Bleomycin Sulfate in Treating Patients With Primary Mediastinal Large B-Cell Lymphoma Withdrawn NCT00983944 Phase 2 EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
15 Efficacy and Safety Study of MDV9300 in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL) Withdrawn NCT02653989 Phase 2
16 Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma Withdrawn NCT02623920 Phase 2 Brentuximab;Bendamustine;Rituximab
17 A Trial of Pembrolizumab (MK-3475) in Participants With Blood Cancers (MK-3475-013/KEYNOTE-013) Active, not recruiting NCT01953692 Phase 1 Lenalidomide
18 Randomized, Open-label, Two-arms, Phase III Comparative Study Assessing the Role of Involved Mediastinal Radiotherapy After Rituximab Containing Chemotherapy Regimens to Patients With Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma Recruiting NCT01599559 Not Applicable

Search NIH Clinical Center for Primary Mediastinal Large B-Cell Lymphoma

Genetic Tests for Primary Mediastinal Large B-Cell Lymphoma

Anatomical Context for Primary Mediastinal Large B-Cell Lymphoma

MalaCards organs/tissues related to Primary Mediastinal Large B-Cell Lymphoma:

41
B Cells, Bone, Heart, Bone Marrow, Thyroid

Publications for Primary Mediastinal Large B-Cell Lymphoma

Articles related to Primary Mediastinal Large B-Cell Lymphoma:

(show top 50) (show all 136)
# Title Authors Year
1
Advances in the management of primary mediastinal large B-cell lymphoma. ( 29741502 )
2018
2
Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation. ( 29467182 )
2018
3
Primary mediastinal large B-cell lymphoma: Outcome of a series of pediatric patients treated with high-dose methotrexate and cytarabine plus anti-CD20. ( 29049862 )
2018
4
Expression pattern of PD-L1 and PD-L2 in classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, and gray zone lymphoma. ( 29377256 )
2018
5
Brentuximab vedotin in relapsed primary mediastinal large B-cell lymphoma: results from a phase 2 clinical trial. ( 28264798 )
2017
6
Performance of a Commercially Available MAL Antibody in the Diagnosis of Primary Mediastinal Large B-Cell Lymphoma. ( 27879516 )
2017
7
Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma. ( 27779774 )
2017
8
Primary mediastinal large B-cell lymphoma. ( 28318892 )
2017
9
PDCD1LG2 (PD-L2) RNA inA situ hybridization is a sensitive, specific, and practical marker of primary mediastinal large B-cell lymphoma. ( 28369778 )
2017
10
J chain and myocyte enhancer factor 2B are useful in differentiating classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. ( 28851661 )
2017
11
Evaluation of primary mediastinal large B cell lymphoma by flow cytometry. ( 28732145 )
2017
12
Primary mediastinal large B cell lymphoma in a woman who is human immunodeficiency virus positive presenting with superior vena cava syndrome: a case report. ( 28187791 )
2017
13
The treatment of primary mediastinal large B-cell lymphoma: a two decades monocentric experience with 98 patients. ( 28415982 )
2017
14
Poor predictive value of positive interim FDG-PET/CT in primary mediastinal large B-cell lymphoma. ( 28634685 )
2017
15
Safety and tolerability of pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma. ( 28490569 )
2017
16
Primary mediastinal large B-cell lymphoma in Japanese children and adolescents. ( 27858330 )
2016
17
Primary mediastinal large B-cell lymphoma and its mimickers: a rare case report with literature review. ( 27568673 )
2016
18
Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma). ( 27124935 )
2016
19
Bowel perforation from occult ileal involvement after diagnosis in a case of primary mediastinal large B-cell lymphoma. ( 27417993 )
2016
20
PET/CT in primary mediastinal large B-cell lymphoma responding to rituximab-CHOP. ( 27183879 )
2016
21
PET/CT in primary mediastinal large B-cell lymphoma responding to rituximab-CHOP: An analysis of 106 patients regarding prognostic significance and implications for subsequent radiotherapy. ( 25971363 )
2016
22
Primary Mediastinal large B-Cell Lymphoma as an incidental finding: report of a case. ( 27094863 )
2016
23
Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting. ( 27806315 )
2016
24
A retrospective analysis of outcomes for primary mediastinal large B-cell lymphoma treated with RCHOP followed by radiotherapy or front-line autologous stem cell transplantation. ( 27884092 )
2016
25
Functional Imaging Using 18-Fluorodeoxyglucose PET in the Management of Primary Mediastinal Large B-Cell Lymphoma: The Contributions of the International Extranodal Lymphoma Study Group. ( 27249743 )
2016
26
Primary Mediastinal Large B-cell Lymphoma Exhibiting Endobronchial Involvement. ( 27803409 )
2016
27
Primary mediastinal large B-cell lymphoma in pregnancy. ( 25956044 )
2016
28
A single-institution retrospective analysis of outcomes for stage I-II primary mediastinal large B-cell lymphoma treated with immunochemotherapy with or without radiotherapy. ( 26159046 )
2016
29
The immunophenotypic spectrum of primary mediastinal large B-cell lymphoma reveals prognostic biomarkers associated with outcome. ( 27419920 )
2016
30
Racial patterns of patients with primary mediastinal large B-cell lymphoma: SEER analysis. ( 27399089 )
2016
31
Favorable outcome of primary mediastinal large B-cell lymphoma patients treated with sequential RCHOP-RICE regimen without radiotherapy. ( 27056383 )
2016
32
Surface Light Chain Expression in Primary Mediastinal Large B-Cell Lymphomas by Multiparameter Flow Cytometry. ( 26386085 )
2015
33
Emerging Biological Insights and Novel Treatment Strategies in Primary Mediastinal Large B-Cell Lymphoma. ( 25805591 )
2015
34
Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression. ( 26549456 )
2015
35
Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling. ( 26135560 )
2015
36
(P109) Standard Immunochemotherapy Plus Radiation vs Dose-Intense Chemotherapy With Rituximab in Stage I/II Primary Mediastinal Large B-Cell Lymphoma: A Single-Institution Experience. ( 25930861 )
2015
37
Rituximab induction therapy, survival benefits, and the increasing selection of radiotherapy as the postinduction treatment in patients with primary mediastinal large B-cell lymphoma. ( 25801492 )
2015
38
Primary mediastinal large B-cell lymphoma arising from thyroid in a renal recipient with Hashimoto's thyroiditis. ( 26191324 )
2015
39
Role of radiation therapy in primary mediastinal large B-cell lymphoma in rituximab era: A US population-based analysis. ( 26270899 )
2015
40
High-dose chemotherapy followed by autologous stem cell transplantation for relapsed/refractory primary mediastinal large B-cell lymphoma. ( 26636287 )
2015
41
Current trends in the treatment of primary mediastinal large B-cell lymphoma - an overview. ( 26843837 )
2015
42
Role of radiotherapy in the treatment of primary mediastinal large B-cell lymphoma. ( 26722265 )
2015
43
Primary mediastinal large B-cell lymphoma. ( 25913715 )
2015
44
Activating mutations affecting the NF-kappa B pathway and EZH2-mediated epigenetic regulation are rare events in primary mediastinal large B-cell lymphoma. ( 25275047 )
2014
45
Primary mediastinal large B-cell lymphoma: a single-center experience in Korea. ( 24724065 )
2014
46
[18F]fluorodeoxyglucose positron emission tomography predicts survival after chemoimmunotherapy for primary mediastinal large B-cell lymphoma: results of the International Extranodal Lymphoma Study Group IELSG-26 Study. ( 24799481 )
2014
47
The impact of R-VACOP-B and interim FDG-PET/CT on outcome in primary mediastinal large B cell lymphoma. ( 24595734 )
2014
48
Primary mediastinal large B-cell lymphoma: Clinical features, prognostic factors and survival with RCHOP in Arab patients in the PET scan era. ( 25125808 )
2014
49
Primary mediastinal large B-cell lymphoma. ( 24952250 )
2014
50
Prognostic significance of pleural or pericardial effusion, and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan. ( 25216682 )
2014

Variations for Primary Mediastinal Large B-Cell Lymphoma

Cosmic variations for Primary Mediastinal Large B-Cell Lymphoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM34215 JAK3 haematopoietic and lymphoid tissue,mediastinum,lymphoid neoplasm,B cell lymphoma unspecified c.1718C>T p.A573V 19:17837197-17837197 1

Expression for Primary Mediastinal Large B-Cell Lymphoma

Search GEO for disease gene expression data for Primary Mediastinal Large B-Cell Lymphoma.

Pathways for Primary Mediastinal Large B-Cell Lymphoma

Pathways related to Primary Mediastinal Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 BCL2 BCL6 IRF4 JAK2 STAT6
2
Show member pathways
12.31 BCL2 BCL6 JAK2
3
Show member pathways
12.29 BCL2 JAK2 STAT6
4
Show member pathways
12.27 BCL2 JAK2 STAT6
5
Show member pathways
12.15 BCL2 IRF4 JAK2 STAT6
6
Show member pathways
12.09 IRF4 JAK2 STAT6
7
Show member pathways
12.07 BCL2 JAK2 STAT6
8 12.07 BCL6 CD274 IRF4 JAK2 STAT6
9
Show member pathways
11.78 BCL2 JAK2 STAT6
10 11.27 BCL2 XPO1
11 11.24 BCL6 XPO1
12 11.22 JAK2 STAT6
13 11.2 JAK2 STAT6
14 11.17 BCL2 JAK2
15 11.11 JAK2 STAT6
16 11.08 BCL2 BCL6 IRF4 JAK2 STAT6
17 11.06 BCL6 IRF4 JAK2 STAT6
18 11.02 IRF4 JAK2
19 10.96 BCL6 XPO1
20
Show member pathways
10.87 IRF4 JAK2

GO Terms for Primary Mediastinal Large B-Cell Lymphoma

Cellular components related to Primary Mediastinal Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.17 BCL2 BCL6 FOXP1 IRF4 JAK2 STAT6
2 nuclear membrane GO:0031965 9.13 BCL2 STAT6 XPO1

Biological processes related to Primary Mediastinal Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.67 BCL2 BCL6 JAK2
2 regulation of cell proliferation GO:0042127 9.63 BCL6 JAK2 STAT6
3 B cell differentiation GO:0030183 9.52 BCL2 BCL6
4 interferon-gamma-mediated signaling pathway GO:0060333 9.51 IRF4 JAK2
5 positive regulation of B cell proliferation GO:0030890 9.48 BCL2 BCL6
6 positive regulation of DNA binding GO:0043388 9.43 IRF4 JAK2
7 regulation of inflammatory response GO:0050727 9.43 BCL6 FOXP1 JAK2
8 axon regeneration GO:0031103 9.4 BCL2 JAK2
9 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 9.37 BCL2 JAK2
10 negative regulation of B cell apoptotic process GO:0002903 9.32 BCL6 FOXP1
11 negative regulation of type 2 immune response GO:0002829 9.16 BCL6 STAT6
12 response to cytokine GO:0034097 9.13 BCL2 CD274 STAT6
13 cytokine-mediated signaling pathway GO:0019221 9.02 BCL2 BCL6 IRF4 JAK2 STAT6

Molecular functions related to Primary Mediastinal Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 BCL2 BCL6 FOXP1 JAK2 STAT6
2 protein phosphatase binding GO:0019903 9.16 BCL2 STAT6
3 sequence-specific DNA binding GO:0043565 9.02 BCL2 BCL6 FOXP1 IRF4 STAT6

Sources for Primary Mediastinal Large B-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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