MCID: PRM139
MIFTS: 16

Primary Melanoma of the Central Nervous System

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Primary Melanoma of the Central Nervous System

MalaCards integrated aliases for Primary Melanoma of the Central Nervous System:

Name: Primary Melanoma of the Central Nervous System 52 58
Primary Melanoma of the Cns 52 58
Primary Leptomeningeal Malignant Melanoma 71
Malignant Melanoma of Meninges 58
Primary Meningeal Melanoma 52
Primary Cns Melanoma 52

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA252050
UMLS 71 C2026298

Summaries for Primary Melanoma of the Central Nervous System

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 252050 Definition Primary melanoma of the central nervous system is a rare tumor of meninges arising from leptomeningeal melanocytes, typically in the perimedullary or high cervical region, in the absence of melanoma outside the CNS. The tumor is typically a darkly pigmented, solid mass, often containing hemorrhagic or necrotic areas, composed of sheets of pleomorphic cells with prominent nucleoli, with frequent mitotic figures and parenchymal invasion. Intracranial tumor may present with signs of raised intracranial pressure, focal neurological symptoms related to tumor location, seizures or subarachnoid hemorrhage, spinal tumor may present with back pain, muscle weakness, numbness, plegia or urinary incontinence. Visit the Orphanet disease page for more resources.

MalaCards based summary : Primary Melanoma of the Central Nervous System, also known as primary melanoma of the cns, is related to melanoma and meningeal melanoma. Affiliated tissues include lymph node, cerebellum and endothelial.

Related Diseases for Primary Melanoma of the Central Nervous System

Diseases related to Primary Melanoma of the Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.2
2 meningeal melanoma 10.2
3 melanoma, cutaneous malignant 10 10.1
4 meningioma, radiation-induced 10.0
5 meningioma, familial 10.0
6 spinal meningioma 10.0
7 secretory meningioma 10.0
8 lymphoplasmacyte-rich meningioma 10.0
9 skin melanoma 10.0
10 meningitis 9.9
11 tuberculous meningitis 9.9
12 melanosis, neurocutaneous 9.8
13 neurofibromatosis 9.8

Graphical network of the top 20 diseases related to Primary Melanoma of the Central Nervous System:



Diseases related to Primary Melanoma of the Central Nervous System

Symptoms & Phenotypes for Primary Melanoma of the Central Nervous System

Drugs & Therapeutics for Primary Melanoma of the Central Nervous System

Search Clinical Trials , NIH Clinical Center for Primary Melanoma of the Central Nervous System

Genetic Tests for Primary Melanoma of the Central Nervous System

Anatomical Context for Primary Melanoma of the Central Nervous System

MalaCards organs/tissues related to Primary Melanoma of the Central Nervous System:

40
Lymph Node, Cerebellum, Endothelial

Publications for Primary Melanoma of the Central Nervous System

Articles related to Primary Melanoma of the Central Nervous System:

(show all 20)
# Title Authors PMID Year
1
Rare cause of spontaneous haemothorax: mediastinal and distant lymph node metastases from uveal melanoma. 61
31753826 2019
2
Acquisition of Somatic NRAS Mutations in Central Nervous System Melanocytes: A Predisposing Risk Factor to Primary Melanoma of the Central Nervous System, a Frequently Forgotten Pitfall in Congenital Nevi. 61
29077579 2018
3
MEK inhibition appears to improve symptom control in primary NRAS-driven CNS melanoma in children. 61
28253523 2017
4
Primary leptomeningeal melanoma. 61
24331626 2014
5
A model for primary melanoma of the CNS implicates NRAS. 61
23580282 2013
6
Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes. 61
23303902 2013
7
Primary melanocytic neoplasms of the central nervous system. 61
20558070 2010
8
Malignant transformation of intramedullary melanocytoma: case report. 61
20657325 2010
9
Primary hemorrhagic intramedullary melanoma. Case report with emphasis on the difficult preoperative diagnosis. 61
17987003 2007
10
Leptomeningeal melanoma of unknown primary site: two cases with an atypical presentation of acute meningitis. 61
18232597 2007
11
Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report. 61
16823290 2006
12
Primitive cerebral melanoma: case report and review of the literature. 61
11311915 2001
13
[Primary melanoma of the central nervous system]. 61
12828166 2000
14
Primary melanoma of the central nervous system: report of a case and review of the literature. 61
1937553 1991
15
Primary dural melanomas: report of two cases and review of the literature. 61
6472585 1984
16
Primary malignant melanoma of the cerebellum: a case with metastases outside the nervous system. 61
342085 1978
17
[Primary melanoma of the central nervous system]. 61
616233 1977
18
Endothelial fenestrations and other vascular alterations in primary melanoma of the central nervous system. 61
4434328 1974
19
Primary melanoma of the central nervous system. Clinical-pathological report of a case, with survey and discussion of the literature. 61
14483757 1962
20
[Contribution to the knowledge of primary melanoma of the central nervous system]. 61
13839410 1960

Variations for Primary Melanoma of the Central Nervous System

Expression for Primary Melanoma of the Central Nervous System

Search GEO for disease gene expression data for Primary Melanoma of the Central Nervous System.

Pathways for Primary Melanoma of the Central Nervous System

GO Terms for Primary Melanoma of the Central Nervous System

Sources for Primary Melanoma of the Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....