MCID: PRM227
MIFTS: 20

Primary Orthostatic Hypotension

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Primary Orthostatic Hypotension

MalaCards integrated aliases for Primary Orthostatic Hypotension:

Name: Primary Orthostatic Hypotension 53
Neurogenic Orthostatic Hypotension 53

Classifications:



Summaries for Primary Orthostatic Hypotension

NIH Rare Diseases : 53 Primary orthostatic hypotension is a rare type of orthostatic hypotension. It is not a disease per se, but a condition caused by several disorders that affect a specific part of the autonomic nervous system, such as multiple system atrophy, young-onset Parkinson’s disease, pure autonomic failure, dopamine beta-hydroxylase deficiency, familial dysautonomia, and pure autonomic failure among others. The autonomic nervous system is the part of the nervous system that regulates certain involuntary body functions such as heart rate, blood pressure, sweating, and bowel and bladder control. Orthostatic hypotension is a form of low blood pressure that happens when standing-up from sitting or lying down. Common symptoms may include dizziness, lightheadedness, generalized weakness, leg buckling, nausea, blurry vision, fatigue, and headaches. Additional symptoms can include chest pain (angina), head and neck pain (often affecting neck and shoulders with a coat hanger distribution), decline in cognitive functioning such as difficulty concentrating, temporary loss of consciousness or “blackout”. Some people with primary orthostatic hypotension may also have high blood pressure when lying down. The treatment depends upon several factors including the specific underlying cause including The treatment depends upon several factors including the specific underlying cause and may include physical counter-maneuvers like lying down, sitting down, squatting clenching buttocks, leg crossing, and support garment and medication.

MalaCards based summary : Primary Orthostatic Hypotension, also known as neurogenic orthostatic hypotension, is related to pure autonomic failure and multiple system atrophy 1. An important gene associated with Primary Orthostatic Hypotension is ACHE (Acetylcholinesterase (Cartwright Blood Group)). The drugs Midodrine and Droxidopa have been mentioned in the context of this disorder. Affiliated tissues include heart and brain.

Related Diseases for Primary Orthostatic Hypotension

Diseases related to Primary Orthostatic Hypotension via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pure autonomic failure 10.1
2 multiple system atrophy 1 9.9
3 parkinson disease, late-onset 9.9
4 postural orthostatic tachycardia syndrome 9.9
5 diabetic autonomic neuropathy 9.9
6 autonomic neuropathy 9.9
7 neuropathy 9.9
8 autonomic dysfunction 9.9

Graphical network of the top 20 diseases related to Primary Orthostatic Hypotension:



Diseases related to Primary Orthostatic Hypotension

Symptoms & Phenotypes for Primary Orthostatic Hypotension

Drugs & Therapeutics for Primary Orthostatic Hypotension

Drugs for Primary Orthostatic Hypotension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midodrine Approved Phase 4,Phase 2 133163-28-7, 42794-76-3 4195
2
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23651-95-8 443940
3 Pyridostigmine Bromide Phase 4 101-26-8
4 Adrenergic Agents Phase 4,Phase 2,Early Phase 1
5 Adrenergic Agonists Phase 4,Phase 2
6 Adrenergic alpha-Agonists Phase 4,Phase 2
7 Cholinergic Agents Phase 4
8 Cholinesterase Inhibitors Phase 4
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1
10 Vasoconstrictor Agents Phase 4,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
12 Anticonvulsants Phase 4
13 Antiparkinson Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
15 Bromides Phase 4
16 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
17 Atomoxetine Hydrochloride Phase 4,Phase 2
18
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
19
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
20 Dopamine Agents Phase 3,Phase 2
21 Protective Agents Phase 3,Early Phase 1
22
Norepinephrine Approved Phase 2 51-41-2 439260
23
Carbidopa Approved Phase 2 28860-95-9 34359 38101
24 Aromatic Amino Acid Decarboxylase Inhibitors Phase 2
25
Yohimbine Approved, Investigational, Vet_approved Early Phase 1 146-48-5 8969
26
Menthol Approved Not Applicable 2216-51-5 16666
27
Melatonin Approved, Nutraceutical, Vet_approved Early Phase 1 73-31-4 896
28 Central Nervous System Depressants Early Phase 1
29 Adrenergic alpha-Antagonists Early Phase 1
30 Adrenergic Antagonists Early Phase 1
31 Mydriatics Early Phase 1
32 Antihypertensive Agents Early Phase 1
33 Antioxidants Early Phase 1
34 Yohimbe Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study Completed NCT02308124 Phase 4 Midodrine;Pyridostigmine Bromide;Midodrine + pyridostigmine
2 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
3 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed NCT00555880 Phase 4 Midodrine hydrochloride;Placebo
4 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
5 Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH Recruiting NCT03350659 Phase 4 Midodrine;Atomoxetine
6 Brain Perfusion & Oxygenation in Parkinson's Disease With NOH Not yet recruiting NCT03229174 Phase 4 Droxidopa;Placebo
7 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
8 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
9 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) Completed NCT01132326 Phase 3 Droxidopa
10 A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa Completed NCT00782340 Phase 3 Placebo;Droxidopa
11 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00633880 Phase 3 Placebo;Droxidopa
12 A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease Completed NCT01176240 Phase 3 Droxidopa
13 A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy Terminated NCT01927055 Phase 3 Droxidopa;Placebo
14 Fipamezole in Neurogenic Orthostatic Hypotension Unknown status NCT00758849 Phase 2 Placebo;Fipamezole
15 Abdominal Binder to Treat Orthostatic Hypotension (OH) in Parkinson's Disease (PD) Completed NCT01971008 Phase 2
16 Phase II Study of Midodrine for Neurogenic Orthostatic Hypotension Completed NCT00004268 Phase 2 midodrine
17 Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa Completed NCT00983814 Phase 2 Droxidopa+Carbidopa;Placebo
18 Norepinephrine Transporter Blockade, Autonomic Failure (NETAF) Recruiting NCT02784535 Phase 2 Atomoxetine;Placebo
19 Norepinephrine Transporter Blockade, Autonomic Failure Recruiting NCT02796209 Phase 2 Atomexetine;Placebo
20 Carbidopa for the Treatment of Excessive Blood Pressure Variability Recruiting NCT02553265 Phase 2 Carbidopa Low Dose;Carbidopa High Dose
21 TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) Active, not recruiting NCT02705755 Phase 2 TD-9855;Placebo
22 Effect of L-Dihydroxyphenylserine (L-DOPS) on Falls in Patients With Neurogenic Orthostatic Hypotension (NOH) Not yet recruiting NCT03567447 Phase 2 Droxidopa
23 Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome Terminated NCT00977171 Phase 2 Droxidopa
24 Study of the Fed-Fast Pharmocokinetics and Bioequivalance of 300mg Capsules of Droxidopa Completed NCT01149629 Phase 1 Droxidopa;Droxidopa;Droxidopa
25 Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension Completed NCT01316666
26 Abdominal Compression in Orthostatic Hypotension Completed NCT01223391 Not Applicable
27 Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension Recruiting NCT02963181 Early Phase 1 Yohimbine;Melatonin
28 Natural History Study of Synucleinopathies Recruiting NCT01799915
29 Breathing Device for Orthostatic Hypotension (OH) Active, not recruiting NCT00962884 Not Applicable
30 Cardiovascular Effects of Exercise in Patients With Parkinson's Disease Not yet recruiting NCT03343574 Not Applicable

Search NIH Clinical Center for Primary Orthostatic Hypotension

Genetic Tests for Primary Orthostatic Hypotension

Anatomical Context for Primary Orthostatic Hypotension

MalaCards organs/tissues related to Primary Orthostatic Hypotension:

41
Heart, Brain

Publications for Primary Orthostatic Hypotension

Articles related to Primary Orthostatic Hypotension:

(show all 22)
# Title Authors Year
1
Impaired cortical autonomic responses during sympathetic activation in Neurogenic Orthostatic Hypotension characterized by post-ganglionic autonomic dysfunction. ( 29901433 )
2018
2
Evaluating the effectiveness of atomoxetine for the treatment of primary orthostatic hypotension in adults. ( 29569329 )
2018
3
Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension. ( 28623420 )
2017
4
Comparison of Heart Rate Variability Parameters to the Autonomic Reflex Screen in Postural Orthostatic Tachycardia Syndrome and Neurogenic Orthostatic Hypotension. ( 29210841 )
2017
5
The Treatment of Primary Orthostatic Hypotension. ( 28092986 )
2017
6
Managing neurogenic orthostatic hypotension in a patient presenting with pure autonomic failure who later developed Parkinson disease. ( 28699048 )
2017
7
Long-term safety of droxidopa in patients with symptomatic neurogenic orthostatic hypotension. ( 27614923 )
2016
8
Safety and Durability of Effect with Long-Term, Open-Label Droxidopa Treatment in Patients with Symptomatic Neurogenic Orthostatic Hypotension (NOH303). ( 27636856 )
2016
9
Analysis of number needed to treat for droxidopa in patients with symptomatic neurogenic orthostatic hypotension. ( 27538531 )
2016
10
Effects of the novel norepinephrine prodrug, droxidopa, on ambulatory blood pressure in patients with neurogenic orthostatic hypotension. ( 27622314 )
2016
11
Droxidopa in neurogenic orthostatic hypotension. ( 26092297 )
2015
12
Droxidopa in Patients with Neurogenic Orthostatic Hypotension Associated with Parkinson's Disease (NOH306A). ( 24326693 )
2013
13
[Pyridostigmine in the treatment of primary orthostatic hypotension]. ( 17492522 )
2007
14
Acetylcholinesterase inhibition: a novel approach in the treatment of neurogenic orthostatic hypotension. ( 12933939 )
2003
15
L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure. ( 11710796 )
2001
16
Improvement of the exercise capacity of a patient with primary orthostatic hypotension (primary sympathetic insufficiency) by programmed subcutaneous noradrenaline administration via microdosing pump. ( 2214613 )
1990
17
Study of autonomic functions in primary orthostatic hypotension. ( 7333808 )
1981
18
Atrial tachypacing for primary orthostatic hypotension. ( 7412811 )
1980
19
Atrial tachypacing in the treatment of a patient with primary orthostatic hypotension. ( 7374710 )
1980
20
Atrial tachypacing for primary orthostatic hypotension. ( 7412813 )
1980
21
The sympathetic-nervous-system defect in primary orthostatic hypotension. ( 831126 )
1977
22
The syndrome of primary orthostatic hypotension. ( 5364007 )
1969

Variations for Primary Orthostatic Hypotension

Expression for Primary Orthostatic Hypotension

Search GEO for disease gene expression data for Primary Orthostatic Hypotension.

Pathways for Primary Orthostatic Hypotension

GO Terms for Primary Orthostatic Hypotension

Sources for Primary Orthostatic Hypotension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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