OT
MCID: PRM050
MIFTS: 34

Primary Orthostatic Tremor (OT)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Primary Orthostatic Tremor

MalaCards integrated aliases for Primary Orthostatic Tremor:

Name: Primary Orthostatic Tremor 54 60
Pot 54 60
Orthostatic Tremor, Primary 54
Shaky Leg Syndrome 54
Ot 54

Characteristics:

Orphanet epidemiological data:

60
primary orthostatic tremor
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

MESH via Orphanet 46 C536418
ICD10 via Orphanet 35 G25.2
UMLS via Orphanet 75 C0878578
Orphanet 60 ORPHA238606

Summaries for Primary Orthostatic Tremor

NIH Rare Diseases : 54 Primary orthostatic tremor (POT) is a rare, progressive movement disorder that causes unsteadiness when standing still, due to a rapid tremor affecting the legs and trunk. The tremor is sometimes described as having �??shaky legs,�?� and it improves or disappears when walking, sitting, or lying down. This may cause people with POT to attempt to sit again or walk immediately after standing, for fear of falling. People with POT may also experience tiredness, physical exhaustion, muscle stiffness or weakness, and/or pain. Symptoms tend to gradually worsen over time and may lead to the need for a mobility aid such as a cane, scooter, or wheelchair. The diagnosis of POT relies on a clinical exam as well as a specialized test called a surface electromyogram (EMG), which measures electrical activity in the muscles. The cause of POT is not completely understood, but the disorder is thought to involve dysfunction of the brain�??s ability to regulate nerve signals that control muscle activity. Some researchers believe that POT is a type of essential tremor. Treatment usually involves medications used to control seizures (anticonvulsants) such as clonazepam or gabapentin. In some cases, treatment may include medications used for Parkinson�??s disease (levodopa or pramipexole), and/or botulinum toxin (Botox) injections in the leg muscles. More than one therapy may be tried before finding one that helps. POT does not appear to alter life expectancy. However, quality of life for people with POT may be severely impaired due to physical symptoms, fear of falling, and uncertainty about the course of the disorder.

MalaCards based summary : Primary Orthostatic Tremor, also known as pot, is related to otosclerosis 1 and tremor. Affiliated tissues include testes, brain and breast, and related phenotypes are tremor and emg abnormality

Related Diseases for Primary Orthostatic Tremor

Diseases related to Primary Orthostatic Tremor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 otosclerosis 1 11.1
2 tremor 10.8
3 vitamin b12 deficiency 10.1
4 muscle hypertrophy 10.0
5 leukemia, chronic lymphocytic 2 9.9
6 breast cancer 9.9
7 leukemia, chronic lymphocytic 9.9
8 retinoblastoma 9.9
9 triiodothyronine receptor auxiliary protein 9.9
10 down syndrome 9.9
11 hypoascorbemia 9.9
12 myelofibrosis 9.9
13 stroke, ischemic 9.9
14 graft-versus-host disease 9.9
15 dilated cardiomyopathy 9.9
16 leukemia 9.9
17 lymphoma 9.9
18 lymphocytic leukemia 9.9
19 dementia 9.9
20 dermatitis 9.9
21 peritonitis 9.9
22 learning disability 9.9
23 acute graft versus host disease 9.9
24 exfoliative dermatitis 9.9
25 leukemia, b-cell, chronic 9.9
26 t-cell prolymphocytic leukemia 9.9

Graphical network of the top 20 diseases related to Primary Orthostatic Tremor:



Diseases related to Primary Orthostatic Tremor

Symptoms & Phenotypes for Primary Orthostatic Tremor

Human phenotypes related to Primary Orthostatic Tremor:

60 33 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 tremor 60 33 hallmark (90%) Very frequent (99-80%) HP:0001337
2 emg abnormality 60 33 hallmark (90%) Very frequent (99-80%) HP:0003457
3 muscle spasm 33 hallmark (90%) HP:0003394
4 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
5 abnormality of extrapyramidal motor function 60 33 occasional (7.5%) Occasional (29-5%) HP:0002071
6 abnormality of movement 60 Very frequent (99-80%)
7 muscle cramps 60 Very frequent (99-80%)
8 abnormality of the musculature 60 Very frequent (99-80%)

Drugs & Therapeutics for Primary Orthostatic Tremor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 rTMS Therapy for Primary Orthostatic Tremor Recruiting NCT02441985 Not Applicable
2 Trans-spinal Direct Current Stimulation in Primary Orthostatic Tremor Recruiting NCT02978924 Not Applicable

Search NIH Clinical Center for Primary Orthostatic Tremor

Genetic Tests for Primary Orthostatic Tremor

Anatomical Context for Primary Orthostatic Tremor

MalaCards organs/tissues related to Primary Orthostatic Tremor:

42
Testes, Brain, Breast, Colon, Bone, Skin, Cortex

Publications for Primary Orthostatic Tremor

Articles related to Primary Orthostatic Tremor:

(show top 50) (show all 2994)
# Title Authors Year
1
Asthma in the melting pot. ( 30465857 )
2019
2
MSOT/CT/MR imaging-guided and hypoxia-maneuvered oxygen self-supply radiotherapy based on one-pot MnO2-mSiO2@Au nanoparticles. ( 30882830 )
2019
3
One-pot synthesis of catalytic molybdenum based nanocomposite nano-fiber membranes for aerosol air remediation. ( 30092529 )
2019
4
One-Pot Synthesis of the Repeating Unit of Type VII Group B Streptococcus Polysaccharide and the Dimer. ( 30888190 )
2019
5
One-pot synthesis of a CdS-reduced graphene oxide-carbon nitride composite for self-powered photoelectrochemical aptasensing of PCB72. ( 30888368 )
2019
6
One-Pot Production of RNA Nanoparticles via Automated Processing and Self Assembly. ( 30888787 )
2019
7
A metal free mild and green approach for tandem opening of 4,6-O-benzylidene acetals to their corresponding 6-O-acetyl derivatives: Application in the synthesis of a trisaccharide using one-pot glycosylation reactions. ( 30889504 )
2019
8
Effects of polyester microfibers on soil physical properties: Perception from a field and a pot experiment. ( 30893616 )
2019
9
One-pot synthesis of benzo[b]fluorenones via a cobalt-catalyzed MHP-directed [3+2] annulation/ring-opening/dehydration sequence. ( 30895992 )
2019
10
Poly(thioether)s from Closed-System One-Pot Reaction of Carbonyl Sulfide and Epoxides by Organic Bases. ( 30896154 )
2019
11
Sweetening the Therapeutic Pot for Type 2 Diabetes with Long Noncoding RNAs. ( 30901557 )
2019
12
Design of combined crosslinked enzyme aggregates (combi-CLEAs) of β-galactosidase and glucose isomerase for the one-pot production of fructose syrup from lactose. ( 30902269 )
2019
13
Single pot bioprocessing for ethanol production from biogenic municipal solid waste. ( 30903822 )
2019
14
One-pot fabrication of magnetic porous Fe3C/MnO/graphitic carbon microspheres for dispersive solid-phase extraction of herbicides prior to their quantification by HPLC. ( 30904959 )
2019
15
PIDA/I2-Mediated Domino Approach for Pyrrolo[1,4]Thiazines and 1,4-Thiazines via a 'One-pot' Morin Rearrangement of N,S-Acetals. ( 30908789 )
2019
16
Nanocrystalline Cu-ZnO as an Green Catalyst for One Pot Synthesis of 4,4'-((phenyl)methylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) Derivatives. ( 30913758 )
2019
17
Efficient Quantification by X-ray Photoelectron Spectroscopy and Thermogravimetric Analyses of the One-Pot Grafting of Two Molecules on the Surface of Iron Oxide Nanoparticles. ( 30913803 )
2019
18
'A light inside a pot': Sites and sources of power emerging from an ethnography of traditional healing in South India. ( 30614381 )
2019
19
Transition-Metal-Free Regioselective One-Pot Synthesis of Aryl Sulfones from Sodium Sulfinates via Quinone Imine Ketal. ( 30623654 )
2019
20
Ligand-Free Iron-Catalyzed C-F Amination of Diarylamines: A One-Pot Regioselective Synthesis of Diaryl Dihydrophenazines. ( 30628796 )
2019
21
Ru-Catalyzed Dehydrogenative Silylation of POSS-Silanols with Hydrosilanes: Its Introduction to One-Pot Synthesis. ( 30629423 )
2019
22
A one-pot metal-free protocol for the synthesis of chalcogenated furans from 1,4-enediones and thiols. ( 30632591 )
2019
23
Robust yet self-healing antifogging/antibacterial dual-functional composite films by a simple one-pot strategy. ( 30634058 )
2019
24
A General One-Pot Approach to Synthesize Binary and Ternary Metal Sulfide Nanocrystals. ( 30635803 )
2019
25
Data-based bivariate uncertainty assessment of extreme rainfall-runoff using copulas: comparison between annual maximum series (AMS) and peaks over threshold (POT). ( 30637530 )
2019
26
One-pot green synthesis of polymeric nanocomposite: Biodegradation studies and application in sorption-degradation of organic pollutants. ( 30639858 )
2019
27
Correction to "One-Pot" Protection, Glycosylation, and Protection-Glycosylation Strategies of Carbohydrates. ( 30653294 )
2019
28
Green one-pot synthesis of carboxymethylcellulose/Zn-based metal-organic framework/graphene oxide bio-nanocomposite as a nanocarrier for drug delivery system. ( 30658803 )
2019
29
An innovative "unlocked mechanism" by a double key avenue for one-pot detection of microRNA-21 and microRNA-141. ( 30662567 )
2019
30
Uric acid supported one-pot solvothermal fabrication of rhombic-like Pt35Cu65 hollow nanocages for highly efficient and stable electrocatalysis. ( 30665171 )
2019
31
One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2-Sp3 Cross-Coupling. ( 30673257 )
2019
32
One-pot synthesis of SiO2@SiO2 core-shell microspheres with controllable mesopore size as a new stationary phase for fast HPLC separation of alkyl benzenes and β-agonists. ( 30673884 )
2019
33
Odorless Isocyanide Chemistry:One-Pot Synthesis of Heterocycles via Passerini and the Post-Modification Tandem Reaction Based on In-situ Capture of Isocyanides. ( 30676019 )
2019
34
Growth of legal pot farms drives smog worries. ( 30679350 )
2019
35
Convenient One-Pot Synthesis of 1,2,3,4-Thiatriazoles Towards a Novel Electron Acceptor for Highly-Efficient Thermally-Activated Delayed-Fluorescence Emitters. ( 30680814 )
2019
36
A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions. ( 30681091 )
2019
37
Fusion of Aromatic Ring to Azoarenes: One-Pot Access to 5,6-Phenanthroliniums for Mitochondria-Targeted Far-Red/NIR Fluorescent Probes. ( 30681876 )
2019
38
Examining derelict pot impacts on harvest in a commercial blue crab Callinectes sapidus fishery. ( 30686413 )
2019
39
Pills to pot: observational analyses of cannabis substitution among medical cannabis users with chronic pain. ( 30690169 )
2019
40
Hydroxyl alkyl ammonium ionic liquid assisted green and one-pot regioselective access to functionalized pyrazolodihydropyridine core and their pharmacological evaluation. ( 30690337 )
2019
41
1,2- trans Glycosylation via Neighboring Group Participation of 2- O-Alkoxymethyl Groups: Application to One-Pot Oligosaccharide Synthesis. ( 30693782 )
2019
42
One-pot synthesis of ZnS nanowires/Cu7S4 nanoparticles/reduced graphene oxide nanocomposites for supercapacitor and photocatalysis applications. ( 30693915 )
2019
43
Corrigendum: Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation. ( 30694014 )
2019
44
A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans. ( 30702732 )
2019
45
Correction: Multifunctional mixed valence N-doped CNT@MFe2O4 hybrid nanomaterials: from engineered one-pot coprecipitation to application in energy storage paper supercapacitors. ( 30706935 )
2019
46
Tandem Rh(III)-Catalyzed C-H Heteroarylation of Indolyl Ketones and Cu(II)-Promoted Intramolecular Cyclization: One-Pot Access to Blue-Emitting Phenanthrone-Type Polyheterocycles. ( 30714379 )
2019
47
Simultaneous determination of multi-class phytohormones in sub-milligram plant samples by one-pot multi-functional derivatization assisted liquid chromatography-tandem mass spectrometry. ( 30715858 )
2019
48
One-pot selective synthesis of azoxy compounds and imines via the photoredox reaction of nitroaromatic compounds and amines in water. ( 30718720 )
2019
49
One-pot synthesized Cu/Au/Pt trimetallic nanoparticles with enhanced catalytic and plasmonic properties as a universal platform for biosensing and cancer theranostics. ( 30720028 )
2019
50
Specific detection of hypochlorite based on the size-selective effect of luminophore integrated MOF-801 synthesized by a one-pot strategy. ( 30720803 )
2019

Variations for Primary Orthostatic Tremor

Expression for Primary Orthostatic Tremor

Search GEO for disease gene expression data for Primary Orthostatic Tremor.

Pathways for Primary Orthostatic Tremor

GO Terms for Primary Orthostatic Tremor

Sources for Primary Orthostatic Tremor

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