MCID: PRM050
MIFTS: 33

Primary Orthostatic Tremor

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Primary Orthostatic Tremor

MalaCards integrated aliases for Primary Orthostatic Tremor:

Name: Primary Orthostatic Tremor 54 60
Pot 54 60
Orthostatic Tremor, Primary 54
Shaky Leg Syndrome 54
Ot 54

Characteristics:

Orphanet epidemiological data:

60
primary orthostatic tremor
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

MESH via Orphanet 46 C536418
ICD10 via Orphanet 35 G25.2
UMLS via Orphanet 75 C0878578
Orphanet 60 ORPHA238606

Summaries for Primary Orthostatic Tremor

NIH Rare Diseases : 54 Primary orthostatic tremor (POT) is a rare, progressive movement disorder that causes unsteadiness when standing still, due to a rapid tremor affecting the legs and trunk. The tremor is sometimes described as having �??shaky legs,�?� and it improves or disappears when walking, sitting, or lying down. This may cause people with POT to attempt to sit again or walk immediately after standing, for fear of falling. People with POT may also experience tiredness, physical exhaustion, muscle stiffness or weakness, and/or pain. Symptoms tend to gradually worsen over time and may lead to the need for a mobility aid such as a cane, scooter, or wheelchair. The diagnosis of POT relies on a clinical exam as well as a specialized test called a surface electromyogram (EMG), which measures electrical activity in the muscles. The cause of POT is not completely understood, but the disorder is thought to involve dysfunction of the brain�??s ability to regulate nerve signals that control muscle activity. Some researchers believe that POT is a type of essential tremor. Treatment usually involves medications used to control seizures (anticonvulsants) such as clonazepam or gabapentin. In some cases, treatment may include medications used for Parkinson�??s disease (levodopa or pramipexole), and/or botulinum toxin (Botox) injections in the leg muscles. More than one therapy may be tried before finding one that helps. POT does not appear to alter life expectancy. However, quality of life for people with POT may be severely impaired due to physical symptoms, fear of falling, and uncertainty about the course of the disorder.

MalaCards based summary : Primary Orthostatic Tremor, also known as pot, is related to otosclerosis 1 and tremor. Affiliated tissues include brain, testes and skin, and related phenotypes are tremor and emg abnormality

Related Diseases for Primary Orthostatic Tremor

Diseases related to Primary Orthostatic Tremor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 otosclerosis 1 11.1
2 tremor 10.8
3 vitamin b12 deficiency 10.1
4 muscle hypertrophy 10.0
5 leukemia, chronic lymphocytic 2 9.9
6 bladder cancer 9.9
7 breast cancer 9.9
8 leukemia, chronic lymphocytic 9.9
9 retinoblastoma 9.9
10 triiodothyronine receptor auxiliary protein 9.9
11 down syndrome 9.9
12 hypoascorbemia 9.9
13 myelofibrosis 9.9
14 stroke, ischemic 9.9
15 graft-versus-host disease 9.9
16 dilated cardiomyopathy 9.9
17 leukemia 9.9
18 lymphoma 9.9
19 lymphocytic leukemia 9.9
20 dementia 9.9
21 dermatitis 9.9
22 peritonitis 9.9
23 learning disability 9.9
24 acute graft versus host disease 9.9
25 exfoliative dermatitis 9.9
26 glyceraldehyde-3-phosphate dehydrogenase deficiency 9.9
27 leukemia, b-cell, chronic 9.9
28 t-cell prolymphocytic leukemia 9.9

Graphical network of the top 20 diseases related to Primary Orthostatic Tremor:



Diseases related to Primary Orthostatic Tremor

Symptoms & Phenotypes for Primary Orthostatic Tremor

Human phenotypes related to Primary Orthostatic Tremor:

60 33 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 tremor 60 33 hallmark (90%) Very frequent (99-80%) HP:0001337
2 emg abnormality 60 33 hallmark (90%) Very frequent (99-80%) HP:0003457
3 muscle spasm 33 hallmark (90%) HP:0003394
4 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
5 abnormality of extrapyramidal motor function 60 33 occasional (7.5%) Occasional (29-5%) HP:0002071
6 abnormality of movement 60 Very frequent (99-80%)
7 muscle cramps 60 Very frequent (99-80%)
8 abnormality of the musculature 60 Very frequent (99-80%)

Drugs & Therapeutics for Primary Orthostatic Tremor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 rTMS Therapy for Primary Orthostatic Tremor Recruiting NCT02441985 Not Applicable
2 Trans-spinal Direct Current Stimulation in Primary Orthostatic Tremor Recruiting NCT02978924 Not Applicable

Search NIH Clinical Center for Primary Orthostatic Tremor

Genetic Tests for Primary Orthostatic Tremor

Anatomical Context for Primary Orthostatic Tremor

MalaCards organs/tissues related to Primary Orthostatic Tremor:

42
Brain, Testes, Skin, Colon, Bone, Cortex, T Cells

Publications for Primary Orthostatic Tremor

Articles related to Primary Orthostatic Tremor:

(show top 50) (show all 3027)
# Title Authors Year
1
MSOT/CT/MR imaging-guided and hypoxia-maneuvered oxygen self-supply radiotherapy based on one-pot MnO2-mSiO2@Au nanoparticles. ( 30882830 )
2019
2
A Low-Molecular-Weight Polyethylenimine/pDNA-VEGF Polyplex System Constructed in a One-Pot Manner for Hindlimb Ischemia Therapy. ( 30965617 )
2019
3
One-pot Facile Synthesis of Sulfur and Nitrogen co- functionalized Graphene material using Novel Deep Eutectic Solvent for Supercapacitor applications. ( 31077560 )
2019
4
One-Pot Synthesis of Poly(glycerol-co-succinic acid) Nanogels for Dermal Delivery. ( 30995401 )
2019
5
One-pot synthesis of a magnetic nanocomposite based on ultrasound-assisted co-precipitation for enrichment of Hg(II) prior to detection by a direct mercury analyzer. ( 30952282 )
2019
6
Living 3,4-(Co)Polymerization of Isoprene/Myrcene and One-Pot Synthesis of a Polyisoprene Blend Catalyzed by Binuclear Rare-Earth Metal Amidinate Complexes. ( 30537360 )
2019
7
Development and application of a high throughput one-pot extraction protocol for quantitative LC-MS/MS analysis of phospholipids in serum and lipoprotein fractions in normolipidemic and dyslipidemic subjects. ( 31035135 )
2019
8
One-pot Three Component Synthesis of 5-sulfenyl-2-iminothiazolines by Cross Dehydrogenative C-S Coupling Using I2/DMSO in Open Air. ( 31074279 )
2019
9
One-pot synthesis of catalytic molybdenum based nanocomposite nano-fiber membranes for aerosol air remediation. ( 30092529 )
2019
10
One-pot synthesis of framework W-doped TS-1 zeolite with robust Lewis acidity for effective oxidative desulfurization. ( 30946392 )
2019
11
TiO2@UiO-68-CIL: A Metal-Organic-Framework-Based Bifunctional Composite Catalyst for a One-Pot Sequential Asymmetric Morita-Baylis-Hillman Reaction. ( 30299930 )
2019
12
Wolf-Lamb-type Catalysis in One Pot Using Electrospun Polymeric Catalyst Membranes. ( 31070820 )
2019
13
Don't Touch My POT! ( 31074222 )
2019
14
Terminal Alkyne-Assisted One-Pot Synthesis of Arylamidines: Carbon Source of Amidine Group from Oxime Chlorides. ( 31074281 )
2019
15
Fast one-pot microwave preparation and plasma modification of porous carbon from waste lignin for energy storage application. ( 31079726 )
2019
16
Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination. ( 31082763 )
2019
17
Regioselective Intermolecular Sulfur-Oxygen Difunctionalization (Phenoxysulfonylation) of Alkynes: One-Pot Construction of ( Z)-β-Phenoxy Vinylsulfones. ( 31083959 )
2019
18
Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling Procedure. ( 31083960 )
2019
19
An ultrasensitive electrochemical detection of tryptase using 3D macroporous reduced graphene oxide nanocomposites by one-pot electrochemical synthesis. ( 31084740 )
2019
20
Facile, one-pot, in aqua synthesis of catalytically competent gold nanoparticles using pyrogallol[4]arene as the sole reagent. ( 31086901 )
2019
21
One-Pot Synthesis of B-Ring ortho-Hydroxylated Sappanin-type Homoisoflavonoids. ( 31090415 )
2019
22
A Novel One-Pot Synthesis of Poly(Propylene Carbonate) Containing Cross-Linked Networks by Copolymerization of Carbon Dioxide, Propylene Oxide, Maleic Anhydride, and Furfuryl Glycidyl Ether. ( 31091817 )
2019
23
Differences of Acer platanoides L. and Tilia cordata Mill. Response patterns/survival strategies during cultivation in extremely polluted mining sludge - A pot trial. ( 31100630 )
2019
24
An efficient one-pot synthesis of polyphenolic amino acids and evaluation of their radical-scavenging activity. ( 31102692 )
2019
25
One-pot sonochemical synthesis of Bi2WO6 nanospheres with multilayer reduced graphene nanosheets modified electrode as rapid electrochemical sensing platform for high sensitive detection of oxidative stress biomarker in biological sample. ( 31103278 )
2019
26
Highly regio- and enantioselective synthesis of chiral intermediate for pregabalin using one-pot bienzymatic cascade of nitrilase and amidase. ( 31104100 )
2019
27
One-Pot Allylation-Intramolecular Vinylogous Michael Addition-Isomerization Cascade of o-Hydroxycinnamates and Congeners: Synthesis of Substituted Benzofuran Derivatives. ( 30835484 )
2019
28
One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water. ( 30836604 )
2019
29
Rapid one-pot synthesis of pyrrole-appended isocorroles. ( 30838359 )
2019
30
Na2S-promoted reduction of azides in water: synthesis of pyrazolopyridines in one pot and evaluation of antimicrobial activity. ( 30839017 )
2019
31
One-pot synthesis of acid-induced in situ aggregating theranostic gold nanoparticles with enhanced retention in tumor cells. ( 30839987 )
2019
32
A One-Pot Ring-Opening/Ring-Closure Sequence for the Synthesis of Polycyclic Spirooxindoles. ( 30840339 )
2019
33
Trypsin mediated one-pot reaction for the synthesis of red fluorescent gold nanoclusters: Sensing of multiple analytes (carbidopa, dopamine, Cu2+, Co2+ and Hg2+ ions). ( 30840923 )
2019
34
Regioselective synthesis of pyrimidine-fused tetrahydropyridines and pyridines by microwave-assisted one-pot reaction. ( 30843127 )
2019
35
KOAc-Catalyzed one-pot three-component 1,3-dipolar cycloaddition of α-diazo compounds, nitrosoarenes, and alkenes: an approach to functionalized isoxazolidines. ( 30845800 )
2019
36
Facile one-pot synthesis of thiol-functionalized mesoporous silica submicrospheres for Tl(I) adsorption: Isotherm, kinetic and thermodynamic studies. ( 30849569 )
2019
37
Soil algae pipe assay: ex situ method for the evaluation of soil quality based on soil algae and its application to the pot test. ( 30849623 )
2019
38
Hazardous waste dewatering and dry mass reduction through hydrophobic modification by a facile one-pot, alkali-assisted hydrothermal reaction. ( 30851593 )
2019
39
The structure of sulfidized zero valent iron by one-pot synthesis: Impact on contaminant selectivity and long-term performance. ( 30859830 )
2019
40
One-Pot Oxidative Coupling/Decyanation of 6,7-Diphenylindolizine-5-carbonitriles and 2,3-Diphenylquinolizine-4-carbonitriles. ( 30864446 )
2019
41
A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1'-cyclopentane] skeleton. ( 30864584 )
2019
42
Single-Pot Access to Bisorganoborinates: Applications in Zweifel Olefination. ( 30864807 )
2019
43
Orthogonal One-Pot Synthesis of Oligosaccharides Based on Glycosyl ortho-Alkynylbenzoates. ( 30869522 )
2019
44
Isothermal double-cycle catalytic system using DNAzyme and RNase H for the highly selective one-pot detection of oligonucleotides. ( 30869659 )
2019
45
Spent pot liner from aluminum industry: genotoxic and mutagenic action on human leukocytes. ( 30875070 )
2019
46
One-Pot Synthesis and Formation Mechanism of Hollow ZSM-5. ( 30875125 )
2019
47
One-Pot FDCA Diester Synthesis from Mucic Acid and Their Solvent-Free Regioselective Polytransesterification for Production of Glycerol-Based Furanic Polyesters. ( 30875923 )
2019
48
Ultrafast one-pot anodic preparation of Co3O4/nanoporous gold composite electrode as an efficient nonenzymatic amperometric sensor for glucose and hydrogen peroxide. ( 30876632 )
2019
49
211At-labeled immunoconjugate via a one-pot three-component double click strategy: practical access to α-emission cancer radiotherapeutics. ( 30881623 )
2019
50
One-Pot Synthesis of Epirubicin-Capped Silver Nanoparticles and Their Anticancer Activity against Hep G2 Cells. ( 30884757 )
2019

Variations for Primary Orthostatic Tremor

Expression for Primary Orthostatic Tremor

Search GEO for disease gene expression data for Primary Orthostatic Tremor.

Pathways for Primary Orthostatic Tremor

GO Terms for Primary Orthostatic Tremor

Sources for Primary Orthostatic Tremor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....