MCID: PRM022
MIFTS: 31

Primary Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Primary Syphilis

MalaCards integrated aliases for Primary Syphilis:

Name: Primary Syphilis 12 15 73
Early Symptomatic Syphilis 12 73
Early Syphilis, Symptomatic 12
Symptomatic Early Syphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4156
ICD9CM 35 091
SNOMED-CT 68 57334003

Summaries for Primary Syphilis

Disease Ontology : 12 A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes.

MalaCards based summary : Primary Syphilis, also known as early symptomatic syphilis, is related to syphilis and congenital syphilis, and has symptoms including syphilitic chancre An important gene associated with Primary Syphilis is EXTL3 (Exostosin Like Glycosyltransferase 3). The drugs Penicillin G and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Primary Syphilis

Graphical network of the top 20 diseases related to Primary Syphilis:



Diseases related to Primary Syphilis

Symptoms & Phenotypes for Primary Syphilis

UMLS symptoms related to Primary Syphilis:


syphilitic chancre

GenomeRNAi Phenotypes related to Primary Syphilis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.32 PDE6D
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.32 DDX41 PDE6D
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.32 PDE6D
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.32 DDX41
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.32 DDX41
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.32 PDE6D
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.32 PDE6D
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.32 PDE6D
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.32 PDE6D

Drugs & Therapeutics for Primary Syphilis

Drugs for Primary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin G Approved, Vet_approved 61-33-6 5904
2 Anti-Infective Agents
3 Anti-Bacterial Agents
4 penicillins
5 Penicillin G Procaine
6 Penicillin G Benzathine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparisons of Serologic Response of Early Syphilis Completed NCT01944358
2 Penicillin Therapeutic Drug Monitoring in the Treatment of Infectious Syphilis. Terminated NCT01540227 Regular Treatment for Syphilis

Search NIH Clinical Center for Primary Syphilis

Genetic Tests for Primary Syphilis

Anatomical Context for Primary Syphilis

MalaCards organs/tissues related to Primary Syphilis:

41
Testes, Skin, Bone, Tonsil, Lymph Node, Tongue

Publications for Primary Syphilis

Articles related to Primary Syphilis:

(show top 50) (show all 136)
# Title Authors Year
1
Primary syphilis occurring as an extensive ulceration on the palatal gingival mucosa diagnosed by immunohistochemical staining. ( 29730886 )
2018
2
Reactor Grids for Prioritizing Syphilis Investigations: Are Primary Syphilis Cases Being Missed? ( 29528995 )
2018
3
Primary Syphilis in the Male Urethra - A Case Report. ( 30202933 )
2018
4
Kissing chancre of primary syphilis. ( 28070492 )
2017
5
Primary syphilis in a secondary stage. ( 28755824 )
2017
6
Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis. ( 29103618 )
2017
7
Unusual primary syphilis: Presentation of a likely case with a review of the stages of acquired syphilis, its differential diagnoses, management, and current recommendations. ( 26756536 )
2016
8
Primary syphilis: An uncommon manifestation in the oral cavity. ( 27502894 )
2016
9
Multiple primary syphilis on the lip, nipple-areola and penis: An immunohistochemical examination of Treponema pallidum localization using an anti-T.A pallidum antibody. ( 25708895 )
2015
10
Balanoposthitis and Penile Edema: Atypical Manifestations of Primary Syphilis. ( 26267879 )
2015
11
Painful and multiple anogenital lesions are common in men with Treponema pallidum PCR-positive primary syphilis without herpes simplex virus coinfection: a cross-sectional clinic-based study. ( 26378262 )
2015
12
Tonsillar chancre as unusual manifestation of primary syphilis. ( 25933085 )
2015
13
Use of Treponema pallidum PCR in testing of ulcers for diagnosis of primary syphilis. ( 25531672 )
2015
14
Oral and Maxillofacial Pathology. Case of the Month. Primary Syphilis. ( 26357808 )
2015
15
Indurative Edema of the Prepuce Mimicing Phimosis, an Atypical Manifestation of Primary Syphilis. ( 26724885 )
2015
16
An erythematous nodule on the nipple: An unusual presentation of primary syphilis. ( 25940793 )
2015
17
Primary syphilis presenting as bilateral nipple-areola eczematoid lesions. ( 24448719 )
2014
18
Primary syphilis in HIV-negative patients is on the rise in Greece: epidemiological data for the period 2005-2012 from a tertiary referral centre in Athens, Greece. ( 25327583 )
2014
19
Evaluation of diagnostic serological results in cases of suspected primary syphilis infection. ( 24722379 )
2014
20
Atypical pearly penile papules mimicking primary syphilis. ( 25580796 )
2014
21
Primary syphilis of the oropharynx: unusual location of a chancre. ( 25193247 )
2014
22
Clinical manifestations of primary syphilis in homosexual men. ( 22846130 )
2012
23
Chancre of the eyelid as manifestation of primary syphilis, and precocious chorioretinitis and uveitis in an HIV-infected patient: a case report. ( 23006858 )
2012
24
Primary syphilis of the urethral meatus complicated by urethral stricture. ( 21890554 )
2011
25
Multiple ulcers in primary syphilis with negative rapid plasma reagin and Venereal Disease Research Laboratory tests: an unusual presentation during the re-emergence of syphilis in Albania. ( 20215630 )
2010
26
Primary syphilis cases in Guangdong Province 1995-2008: opportunities for linking syphilis control and regional development. ( 21192782 )
2010
27
Primary syphilis of the finger. ( 20531029 )
2010
28
Clarithromycin treatment failure due to macrolide resistance in Treponema pallidum in a patient with primary syphilis. ( 20169316 )
2010
29
Mondor's disease of the penis associated with primary syphilis. ( 19541898 )
2009
30
Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, China. ( 19583516 )
2009
31
Expedited intervention services for possible occult primary syphilis among MSM with asymptomatic incident syphilis. ( 19661841 )
2009
32
The Architect Syphilis assay for antibodies to Treponema pallidum: an automated screening assay with high sensitivity in primary syphilis. ( 18790859 )
2009
33
Primary syphilis on the finger. ( 18663310 )
2008
34
Pseudotumoral primary syphilis on the tongue in an HIV positive patient. ( 18355362 )
2008
35
Male patient with a genital ulceration. Primary syphilis. ( 18246892 )
2008
36
Primary syphilis. ( 18397550 )
2008
37
Primary syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin. ( 18823862 )
2008
38
Unilateral penile swelling: an unusual presentation of primary syphilis? ( 18725559 )
2008
39
Rectal cancer or rectal chancre? Beware of primary syphilis. ( 18313998 )
2008
40
An evaluation of the relative sensitivities of the venereal disease research laboratory test and the Treponema pallidum particle agglutination test among patients diagnosed with primary syphilis. ( 18080352 )
2007
41
Primary syphilis presenting as balanitis. ( 17623510 )
2007
42
The influence of concomitant HIV infection on the serological diagnosis of primary syphilis in southern Africa. ( 18250927 )
2007
43
Acquired primary syphilis on a child's lip. ( 17533506 )
2007
44
Case series descriptive analysis of a primary syphilis outbreak in Edmonton, Alberta, July 2004-April 2006. ( 17520772 )
2007
45
Presternal indurated ulceration: primary syphilis. ( 16484829 )
2006
46
A case of primary syphilis in the rectum. ( 16224168 )
2005
47
Primary syphilis of oral mucosa: case report of an unusual manifestation. ( 15470997 )
2004
48
Genital lesions of primary syphilis. ( 14722141 )
2004
49
Primary syphilis. ( 17656890 )
2002
50
A patient with primary syphilis of the finger. ( 11800158 )
2001

Variations for Primary Syphilis

Expression for Primary Syphilis

Search GEO for disease gene expression data for Primary Syphilis.

Pathways for Primary Syphilis

GO Terms for Primary Syphilis

Sources for Primary Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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