MCID: PRM022
MIFTS: 32

Primary Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Primary Syphilis

MalaCards integrated aliases for Primary Syphilis:

Name: Primary Syphilis 12 15 71
Early Symptomatic Syphilis 12 71
Early Syphilis, Symptomatic 12
Symptomatic Early Syphilis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4156
ICD9CM 34 091
SNOMED-CT 67 57334003
UMLS 71 C0153139 C2931317

Summaries for Primary Syphilis

Disease Ontology : 12 A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes.

MalaCards based summary : Primary Syphilis, also known as early symptomatic syphilis, is related to urethritis and chancroid, and has symptoms including syphilitic chancre An important gene associated with Primary Syphilis is CD40LG (CD40 Ligand), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and tongue.

Related Diseases for Primary Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Primary Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 urethritis 30.3 CD40LG CD4
2 chancroid 30.3 CD40LG CD4
3 chorioretinitis 30.2 CD40LG CD4
4 syphilis 30.2 TPR POLA1 MYH9 DDX41 CD40LG CD4
5 optic papillitis 30.1 CD40LG CD4
6 papilledema 30.0 CD40LG CD4
7 bejel 29.2 TPR POLA1 EPB41L3
8 tertiary syphilis 28.8 TPR MYH9 DDX41 CD40LG CD4
9 secondary syphilis 28.0 TPR POLA1 MYH9 EPB41L3 DDX41 CD40LG
10 latent syphilis 27.7 TPR POLA1 MYH9 DDX41 CD40LG CD4
11 congenital syphilis 27.7 TPR POLA1 MYH9 EPB41L3 DDX41 CD40LG
12 late yaws 10.4 TPR CD40LG
13 late congenital syphilis 10.4 DDX41 CD40LG
14 riedel's fibrosing thyroiditis 10.3 CD40LG CD4
15 cork-handlers' disease 10.3 CD40LG CD4
16 syphilitic meningitis 10.3 CD40LG CD4
17 gastroduodenitis 10.3 CD40LG CD4
18 duodenitis 10.3 CD40LG CD4
19 norwegian scabies 10.3 CD40LG CD4
20 neuroretinitis 10.3 CD40LG CD4
21 viral exanthem 10.3 CD40LG CD4
22 acute retinal necrosis syndrome 10.3 CD40LG CD4
23 granulomatous hepatitis 10.3 CD40LG CD4
24 cerebral lymphoma 10.3 CD40LG CD4
25 gastrointestinal tuberculosis 10.3 CD40LG CD4
26 west nile encephalitis 10.3 CD40LG CD4
27 mononeuritis of upper limb and mononeuritis multiplex 10.3 CD40LG CD4
28 mononeuritis multiplex 10.3 CD40LG CD4
29 cerebritis 10.3 CD40LG CD4
30 cat-scratch disease 10.3 CD40LG CD4
31 parotid disease 10.3 CD40LG CD4
32 exanthema subitum 10.3 CD40LG CD4
33 trichinosis 10.3 CD40LG CD4
34 granulomatous dermatitis 10.3 CD40LG CD4
35 splenic sequestration 10.3 CD40LG CD4
36 abdominal tuberculosis 10.3 CD40LG CD4
37 bartonellosis 10.3 CD40LG CD4
38 pityriasis rosea 10.3 CD40LG CD4
39 blastomycosis 10.3 CD40LG CD4
40 cardiovascular syphilis 10.3 TPR DDX41
41 scleral disease 10.3 CD40LG CD4
42 lung abscess 10.3 CD40LG CD4
43 adenoid hypertrophy 10.3 CD40LG CD4
44 sporotrichosis 10.3 CD40LG CD4
45 uveoparotid fever 10.3 CD40LG CD4
46 chronic meningitis 10.3 CD40LG CD4
47 parotitis 10.3 CD40LG CD4
48 good syndrome 10.3 CD40LG CD4
49 chlamydia pneumonia 10.3 CD40LG CD4
50 mite infestation 10.3 CD40LG CD4

Graphical network of the top 20 diseases related to Primary Syphilis:



Diseases related to Primary Syphilis

Symptoms & Phenotypes for Primary Syphilis

UMLS symptoms related to Primary Syphilis:


syphilitic chancre

Drugs & Therapeutics for Primary Syphilis

Drugs for Primary Syphilis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents
2 Anti-Infective Agents
3 penicillins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparisons of Treatment Response to Standard Treatment With Penicillin Between HIV-infected and HIV-uninfected Patients With Syphilis Completed NCT01944358

Search NIH Clinical Center for Primary Syphilis

Genetic Tests for Primary Syphilis

Anatomical Context for Primary Syphilis

MalaCards organs/tissues related to Primary Syphilis:

40
Testes, Skin, Tongue, Tonsil, Whole Blood, Lymph Node, Cervix

Publications for Primary Syphilis

Articles related to Primary Syphilis:

(show top 50) (show all 503)
# Title Authors PMID Year
1
Disabling complications of primary syphilis in a 34-year-old woman living with HIV. 61
32024443 2020
2
Herpetiform Manifestation of Primary Syphilis: A Case Series. 61
32011725 2020
3
Neurosyphilis presenting as acute ischemic stroke. 61
31941739 2020
4
MiR-101-3p down-regulates TLR2 expression, leading to reduction in cytokines production by T. pallidum-stimulated macrophages. 61
31930972 2020
5
Usefulness of New Automated Treponemal Tests in the Diagnosis of Early Syphilis: A Series of 15 Cases. 61
31831159 2019
6
The Epidemiological and Clinical Characteristics of the Epidemic of Syphilis in Barcelona. 61
31587806 2019
7
Traumatic ulcerative granuloma with stromal eosinophilia - clinical case report, literature review, and differential diagnosis. 61
31706333 2019
8
Accuracy of PCR and serological testing for the diagnosis of primary syphilis: Both tests are necessary. 61
31551003 2019
9
Tolerability of IM penicillin G benzathine diluted or not with local anesthetics, or different gauge needles for syphilis treatment: a randomized clinical trial. 61
31646969 2019
10
Enhancing the Control of Syphilis Among Men Who Have Sex With Men by Focusing on Acute Infectious Primary Syphilis and Core Transmission Groups. 61
31356529 2019
11
Getting to the bottom of it: Sexual positioning and stage of syphilis at diagnosis, and implications for syphilis screening. 61
31420649 2019
12
[Implementation of the reverse screening syphilis algorithm in a clinical laboratory]. 61
31859779 2019
13
Neurosyphilis. 61
31533185 2019
14
The oral manifestations of syphilitic disease: a case report. 61
31345262 2019
15
Insights into the genetic variation profile of tprK in Treponema pallidum during the development of natural human syphilis infection. 61
31329597 2019
16
[A chancre instead of cancer]. 61
31361406 2019
17
Dermatologically challenging syphilis presentation. 61
31112488 2019
18
Novel tp0548 Sequence-Type of Treponema pallidum Identified in Barcelona, Spain. 61
30461599 2019
19
Neurosyphilis: Concordance between cerebrospinal fluid analysis and subsequent antibiotic strategy for patients undergoing evaluation of a diagnosis of neurosyphilis. 61
30853444 2019
20
Unusual Presentation of Primary Syphilis as Pharyngeal Chancre: A Case Report. 61
31428723 2019
21
Primary Syphilis in the Male Urethra: A Case Report. 61
30202933 2019
22
Performance of Treponemal Tests for the Diagnosis of Syphilis. 61
29986091 2019
23
Profile of the tprK gene in primary syphilis patients based on next-generation sequencing. 61
30789907 2019
24
Ocular Syphilis: An Update. 61
29020491 2019
25
Clinical factors associated with syphilis concordance in men in sexual partnerships: a cross-sectional couples study. 61
29191816 2018
26
Primary syphilis occurring as an extensive ulceration on the palatal gingival mucosa diagnosed by immunohistochemical staining. 61
29730886 2018
27
Disease Pattern among Sexually Transmitted Infection Clinic Attendees: A Hospital-Based Study. 61
30504980 2018
28
Reactor Grids for Prioritizing Syphilis Investigations: Are Primary Syphilis Cases Being Missed? 61
29528995 2018
29
Rectal syphilitic ulcer. 61
30032631 2018
30
Centers for Disease Control and Prevention Syphilis Summit-Diagnostics and Laboratory Issues. 61
30102681 2018
31
Utility of antitreponemal IgM testing in the diagnosis of early and repeat syphilis among HIV-infected and non-infected patients. 61
29629652 2018
32
Primary syphilitic proctitis : case report and literature review. 61
30350534 2018
33
Primary syphilis in a secondary stage. 61
28755824 2018
34
Frequency of Treponema pallidum invasion into cerebrospinal fluid in primary or secondary early-stage syphilis. 61
29229275 2018
35
Neurosyphilis as a Cause of Transverse Myelitis in a Teenage Girl. 61
29602529 2018
36
Sensitive detection of Treponema pallidum DNA from the whole blood of patients with syphilis by the nested PCR assay. 61
29739928 2018
37
CDC Syphilis Summit - Diagnostics and Laboratory Issues. 61
29596224 2018
38
Mathematical Analysis of the Transmission Dynamics of HIV Syphilis Co-infection in the Presence of Treatment for Syphilis. 61
29282597 2018
39
A five year retrospective study on Syphilis in the Sexual Transmitted Disease Centre (STDC) of the teaching Hospital Umberto I in Rome. 61
29215133 2018
40
Cross-sectional study of Treponema pallidum PCR in diagnosis of primary and secondary syphilis. 61
29090453 2018
41
A Case of Ceftriaxone-Induced Acute Generalized Exanthematous Pustulosis/Generalized Pustular Psoriasis Overlap. 61
29681811 2018
42
The Etiology of Genital Ulcer Disease and Coinfections With Chlamydia trachomatis and Neisseria gonorrhoeae in Zimbabwe: Results From the Zimbabwe STI Etiology Study. 61
29240636 2018
43
Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis. 61
29103618 2017
44
Syphilis Resurgence in Belgrade, Serbia, in the New Millennium: An Outbreak in 2014. 61
29346849 2017
45
Factors associated with syphilis treatment failure and reinfection: a longitudinal cohort study in Shenzhen, China. 61
28903736 2017
46
Usefulness of Positron Emission Tomography in Patients with Syphilis: A Systematic Review of Observational Studies. 61
28469107 2017
47
Primary syphilis: An uncommon manifestation in the oral cavity. 61
27502894 2017
48
[Circulating levels of Th1- and Th2-chemokines increase in patients with early syphilis]. 61
28274320 2017
49
A retrospective cross-sectional quantitative molecular approach in biological samples from patients with syphilis. 61
28161356 2017
50
Efficacy of Doxycycline in the Treatment of Syphilis. 61
27795370 2017

Variations for Primary Syphilis

Expression for Primary Syphilis

Search GEO for disease gene expression data for Primary Syphilis.

Pathways for Primary Syphilis

Pathways related to Primary Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.2 CD40LG CD4

GO Terms for Primary Syphilis

Biological processes related to Primary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actomyosin structure organization GO:0031032 8.62 MYH9 EPB41L3

Molecular functions related to Primary Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein membrane anchor GO:0043495 8.62 TPR MYH9

Sources for Primary Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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