MCID: PRM026
MIFTS: 35

Primary Systemic Mycosis

Categories: Infectious diseases

Aliases & Classifications for Primary Systemic Mycosis

MalaCards integrated aliases for Primary Systemic Mycosis:

Name: Primary Systemic Mycosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050292

Summaries for Primary Systemic Mycosis

Disease Ontology : 12 A systemic mycosis that results in infection located in human body, has material basis in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

MalaCards based summary : Primary Systemic Mycosis is related to phaeohyphomycosis and coccidioidomycosis. An important gene associated with Primary Systemic Mycosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include lung, skin and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Primary Systemic Mycosis

Diseases related to Primary Systemic Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 phaeohyphomycosis 31.7 CALM1 CALM2 CALM3 CARD9
2 coccidioidomycosis 31.7 CARD9 CLEC7A CYP51A1 IL10
3 sporotrichosis 31.3 CALM1 CALM2 CALM3 IFNG IL10
4 paracoccidioidomycosis 31.2 IFNG IL10 IL4 TLR2 TNF
5 adiaspiromycosis 11.1
6 allescheriosis 11.1
7 blastomycosis 11.1
8 histoplasmosis 11.1
9 candidiasis, familial, 2 10.3 CARD9 CLEC7A
10 cow milk allergy 10.3 IL10 TNF
11 subcutaneous mycosis 10.3 CARD9 CLEC7A
12 transient hypogammaglobulinemia 10.3 IL10 TNF
13 microscopic polyangiitis 10.3 IL10 TNF
14 multifocal choroiditis 10.3 IL10 TNF
15 punctate inner choroidopathy 10.3 IL10 TNF
16 trench fever 10.3 TLR2 TNF
17 retinitis pigmentosa 22 10.3 IL10 IL4
18 palladium allergic contact dermatitis 10.3 IL10 IL17A
19 kashin-beck disease 10.2 IL1B TNF
20 burns 10.2 IL1B TNF
21 exudative glomerulonephritis 10.2 IL1B TNF
22 vulvar vestibulitis syndrome 10.2 IL1B TNF
23 endocarditis 10.2 IL10 TLR2 TNF
24 periodontitis, chronic 10.2 IL1B TLR2
25 rheumatic heart disease 10.2 IL10 IL4 TNF
26 nose disease 10.2 IL10 IL4 TNF
27 rubella 10.2 IL10 IL4 TNF
28 parasitic helminthiasis infectious disease 10.2 IL10 IL4 TNF
29 prosthetic joint infection 10.2 IL1B TLR2
30 autoimmune vasculitis 10.2 IL1B IL4
31 ceroid lipofuscinosis, neuronal, 11 10.2 CALM1 CALM2 CALM3
32 primary cutaneous amyloidosis 10.2 CALM1 CALM2 CALM3
33 cardiac arrest 10.2 CALM1 CALM2 CALM3
34 catecholaminergic polymorphic ventricular tachycardia 10.2 CALM1 CALM2 CALM3
35 uveal disease 10.2 IL10 IL17A TNF
36 tropical endomyocardial fibrosis 10.2 IL10 IL4 TNF
37 endomyocardial fibrosis 10.2 IL10 IL4 TNF
38 tungiasis 10.2 IL10 IL4 TNF
39 long qt syndrome 15 10.1 CALM1 CALM2 CALM3
40 long qt syndrome 1 10.1 CALM1 CALM2 CALM3
41 otomycosis 10.1 CALM1 CALM2 CALM3
42 external ear disease 10.1 CALM1 CALM2 CALM3
43 emery-dreifuss muscular dystrophy 5, autosomal dominant 10.1 CALM1 CALM2 CALM3
44 mycobacterium abscessus 10.1 CLEC7A TLR2 TNF
45 otitis externa 10.1 CALM1 CALM2 CALM3
46 spontaneous ocular nystagmus 10.1 CALM1 CALM2 CALM3
47 chromoblastomycosis 10.1 CARD9 CLEC7A IL4
48 pulmonary edema 10.1 IL10 IL1B TNF
49 pyelonephritis 10.1 IL10 IL1B TNF
50 deafness, autosomal recessive 44 10.1 CALM1 CALM2 CALM3

Graphical network of the top 20 diseases related to Primary Systemic Mycosis:



Diseases related to Primary Systemic Mycosis

Symptoms & Phenotypes for Primary Systemic Mycosis

GenomeRNAi Phenotypes related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.3 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.3 CALM2 CLEC7A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.3 CLEC7A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.3 CLEC7A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.3 IL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.3 RHAG
7 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.3 CLEC7A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.3 RHAG
9 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.3 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.3 CALM2 CLEC7A IL10 RHAG
11 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.3 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.3 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.3 CLEC7A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.3 CLEC7A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.3 CLEC7A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.3 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.3 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.3 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.3 CLEC7A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-182 10.3 RHAG
21 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.3 CLEC7A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.3 IL10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.3 CLEC7A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.3 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.3 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.3 CLEC7A IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.3 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.3 CLEC7A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.3 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.3 IL10
31 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.3 CLEC7A
32 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.3 IL10
33 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.3 CLEC7A
34 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.3 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.3 IL10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.3 CALM2 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.3 CLEC7A
38 Increased shRNA abundance (Z-score > 2) GR00366-A-97 10.3 RHAG
39 Reduced mammosphere formation GR00396-S 9.1 CALM1 CALM2 CALM3 CLEC7A CYP51A1 IL17A

MGI Mouse Phenotypes related to Primary Systemic Mycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 CARD9 CLEC7A IFNG IL10 IL17A IL1B
2 homeostasis/metabolism MP:0005376 10 CARD9 CLEC7A CYP51A1 IFNG IL10 IL17A
3 digestive/alimentary MP:0005381 9.97 CLEC7A CYP51A1 IFNG IL10 IL17A IL4
4 craniofacial MP:0005382 9.95 CYP51A1 IFNG IL10 IL17A IL1B IL4
5 immune system MP:0005387 9.85 CARD9 CLEC7A CYP51A1 IFNG IL10 IL17A
6 respiratory system MP:0005388 9.5 CLEC7A IFNG IL10 IL17A IL4 TLR2
7 skeleton MP:0005390 9.23 CYP51A1 IFNG IL10 IL17A IL1B IL4

Drugs & Therapeutics for Primary Systemic Mycosis

Search Clinical Trials , NIH Clinical Center for Primary Systemic Mycosis

Genetic Tests for Primary Systemic Mycosis

Anatomical Context for Primary Systemic Mycosis

MalaCards organs/tissues related to Primary Systemic Mycosis:

41
Lung, Skin, Bone, Heart, Lymph Node, Eye, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Primary Systemic Mycosis:

19
Human Body

Publications for Primary Systemic Mycosis

Variations for Primary Systemic Mycosis

Expression for Primary Systemic Mycosis

Search GEO for disease gene expression data for Primary Systemic Mycosis.

Pathways for Primary Systemic Mycosis

Pathways related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CALM1 CALM2 CALM3 CARD9 CLEC7A IFNG
2
Show member pathways
13.71 CALM1 CALM2 CALM3 IFNG IL10 IL17A
3
Show member pathways
13.58 CALM1 CALM2 CALM3 IFNG IL10 IL17A
4
Show member pathways
13.4 CALM1 CALM2 CALM3 IFNG IL10 IL17A
5
Show member pathways
13.26 CALM1 CALM2 CALM3 IFNG IL1B IL4
6
Show member pathways
13.1 CALM1 CALM2 CALM3 IL1B TLR2 TNF
7
Show member pathways
13.06 CARD9 IFNG IL10 IL1B TLR2 TNF
8
Show member pathways
12.92 CALM1 CALM2 CALM3 IFNG IL10 IL17A
9 12.87 CALM1 CALM2 CALM3 IFNG IL4
10
Show member pathways
12.83 IFNG IL1B IL4 TLR2 TNF
11
Show member pathways
12.78 CALM1 CALM2 CALM3 IL1B TLR2 TNF
12
Show member pathways
12.7 CALM1 CALM2 CALM3 IL1B TLR2 TNF
13
Show member pathways
12.69 CALM1 CALM2 CALM3 IFNG IL10 IL4
14
Show member pathways
12.66 IFNG IL10 IL17A IL1B IL4 TLR2
15
Show member pathways
12.65 IFNG IL10 IL17A IL1B TNF
16
Show member pathways
12.65 CALM1 CALM2 CALM3 IL4 TNF
17
Show member pathways
12.6 CALM1 CALM2 CALM3 IFNG IL4 TNF
18
Show member pathways
12.56 CALM1 CALM2 CALM3 IL1B
19 12.55 CARD9 IFNG IL10 IL17A IL1B IL4
20
Show member pathways
12.52 CALM1 CALM2 CALM3 TNF
21
Show member pathways
12.52 CALM1 CALM2 CALM3 CARD9 CLEC7A IL1B
22
Show member pathways
12.41 IFNG IL17A IL1B IL4 TLR2 TNF
23
Show member pathways
12.39 CALM1 CALM2 CALM3 IFNG IL1B TNF
24
Show member pathways
12.38 IFNG IL1B IL4 TNF
25
Show member pathways
12.35 IFNG IL10 IL17A IL1B IL4 TNF
26
Show member pathways
12.33 IFNG IL10 IL1B IL4 TLR2 TNF
27
Show member pathways
12.28 IFNG IL1B IL4 TLR2 TNF
28
Show member pathways
12.26 CALM1 CALM2 CALM3 IL1B TLR2
29
Show member pathways
12.19 CALM1 CALM2 CALM3 TNF
30 12.18 CALM1 CALM2 CALM3 IFNG IL1B TNF
31
Show member pathways
12.17 CALM1 CALM2 IFNG IL10 IL17A IL1B
32
Show member pathways
12.14 IFNG IL1B IL4 TLR2 TNF
33
Show member pathways
12.14 IFNG IL10 IL17A IL1B TLR2 TNF
34
Show member pathways
12.13 CALM1 CALM2 CALM3 IFNG IL10 IL17A
35 12.09 IFNG IL1B IL4 TNF
36 12.09 IL10 IL17A IL1B IL4 TNF
37 12.07 IFNG IL10 IL4 TNF
38 12.06 IFNG IL1B TNF
39
Show member pathways
12.04 CALM1 CALM2 CALM3
40
Show member pathways
12.02 CALM1 CALM2 CALM3
41
Show member pathways
12 IFNG IL1B IL4
42
Show member pathways
12 CALM1 CALM2 CALM3
43 11.99 IFNG IL10 IL1B TLR2 TNF
44
Show member pathways
11.97 CALM1 CALM2 CALM3
45 11.96 CALM1 CALM2 CALM3
46 11.95 CALM1 CALM2 CALM3
47 11.95 IFNG IL17A IL1B TLR2 TNF
48
Show member pathways
11.93 CALM1 CALM2 CALM3
49 11.93 IL1B IL4 TNF
50 11.92 CALM1 CALM2 CALM3

GO Terms for Primary Systemic Mycosis

Cellular components related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.67 CALM1 CALM2 CALM3 UNC119
2 vesicle GO:0031982 9.62 CALM1 CALM2 CALM3 IL1B
3 sarcomere GO:0030017 9.58 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.46 CALM1 CALM2 CALM3 UNC119
5 spindle microtubule GO:0005876 9.43 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
7 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 CLEC7A IL10 IL17A IL1B TLR2 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 IL10 IL1B TNF
3 defense response to Gram-positive bacterium GO:0050830 9.9 CARD9 TLR2 TNF
4 calcium-mediated signaling GO:0019722 9.89 CALM1 CALM2 CALM3
5 positive regulation of JNK cascade GO:0046330 9.89 CARD9 IL1B TNF
6 regulation of insulin secretion GO:0050796 9.88 IFNG IL1B TNF
7 response to glucocorticoid GO:0051384 9.88 IL10 IL1B TNF
8 response to calcium ion GO:0051592 9.87 CALM1 CALM2 CALM3
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL1B TLR2 TNF
10 substantia nigra development GO:0021762 9.83 CALM1 CALM2 CALM3
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL1B TNF
12 regulation of cytokinesis GO:0032465 9.83 CALM1 CALM2 CALM3
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.82 IL1B TLR2 TNF
14 regulation of heart rate GO:0002027 9.81 CALM1 CALM2 CALM3
15 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.81 CALM1 CALM2 CALM3
16 immune response GO:0006955 9.8 IFNG IL10 IL17A IL1B IL4 TLR2
17 positive regulation of interleukin-8 production GO:0032757 9.79 IL1B TLR2 TNF
18 positive regulation of protein dephosphorylation GO:0035307 9.78 CALM1 CALM2 CALM3
19 positive regulation of protein autophosphorylation GO:0031954 9.77 CALM1 CALM2 CALM3
20 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.77 CALM1 CALM2 CALM3
21 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.76 CALM1 CALM2 CALM3
22 positive regulation of osteoclast differentiation GO:0045672 9.75 IFNG IL17A TNF
23 regulation of cardiac muscle contraction GO:0055117 9.74 CALM1 CALM2 CALM3
24 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
25 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B TNF
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.73 IL1B TNF
27 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.73 CALM1 CALM3
28 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
29 positive regulation of interleukin-6 production GO:0032755 9.73 CARD9 IL1B TLR2 TNF
30 regulation of synaptic vesicle endocytosis GO:1900242 9.72 CALM1 CALM3
31 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR2
32 establishment of protein localization to membrane GO:0090150 9.72 CALM1 CALM3
33 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.72 CALM1 CALM2 CALM3
34 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IFNG IL1B TNF
37 positive regulation of protein serine/threonine kinase activity GO:0071902 9.71 CALM1 CALM2 CALM3 IFNG
38 positive regulation of MHC class II biosynthetic process GO:0045348 9.7 IL10 IL4
39 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
40 regulation of high voltage-gated calcium channel activity GO:1901841 9.7 CALM1 CALM3
41 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.7 CALM1 CALM2 CALM3
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
43 positive regulation of neuroinflammatory response GO:0150078 9.69 IL1B TNF
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL10 IL1B TNF
45 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
46 positive regulation of interleukin-23 production GO:0032747 9.68 IFNG IL17A
47 chronic inflammatory response to antigenic stimulus GO:0002439 9.67 IL1B TNF
48 regulation of isotype switching GO:0045191 9.67 IL10 IL4
49 sequestering of triglyceride GO:0030730 9.67 IL1B TNF
50 detection of calcium ion GO:0005513 9.67 CALM1 CALM2 CALM3

Molecular functions related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.8 CALM1 CALM2 CALM3 CARD9 IL1B
2 ion channel binding GO:0044325 9.72 CALM1 CALM2 CALM3
3 disordered domain specific binding GO:0097718 9.65 CALM1 CALM2 CALM3
4 protein serine/threonine kinase activator activity GO:0043539 9.63 CALM1 CALM2 CALM3
5 nitric-oxide synthase binding GO:0050998 9.54 CALM1 CALM3
6 titin binding GO:0031432 9.54 CALM1 CALM2 CALM3
7 calcium channel inhibitor activity GO:0019855 9.52 CALM1 CALM2
8 signaling pattern recognition receptor activity GO:0008329 9.51 CLEC7A TLR2
9 adenylate cyclase binding GO:0008179 9.5 CALM1 CALM2 CALM3
10 nitric-oxide synthase regulator activity GO:0030235 9.49 CALM1 CALM3
11 type 3 metabotropic glutamate receptor binding GO:0031800 9.43 CALM1 CALM3
12 protein phosphatase activator activity GO:0072542 9.43 CALM1 CALM2 CALM3
13 cytokine activity GO:0005125 9.43 IFNG IL10 IL17A IL1B IL4 TNF
14 adenylate cyclase activator activity GO:0010856 9.33 CALM1 CALM2 CALM3
15 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Primary Systemic Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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