MCID: PRM026
MIFTS: 35

Primary Systemic Mycosis

Categories: Infectious diseases

Aliases & Classifications for Primary Systemic Mycosis

MalaCards integrated aliases for Primary Systemic Mycosis:

Name: Primary Systemic Mycosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050292

Summaries for Primary Systemic Mycosis

Disease Ontology : 12 A systemic mycosis that results in infection located in human body, has material basis in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

MalaCards based summary : Primary Systemic Mycosis is related to sporotrichosis and coccidioidomycosis. An important gene associated with Primary Systemic Mycosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include t cells, skin and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Primary Systemic Mycosis

Diseases related to Primary Systemic Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
# Related Disease Score Top Affiliating Genes
1 sporotrichosis 32.3 IFNG IL10
2 coccidioidomycosis 31.5 CARD9 CLEC7A CYP51A1 IL10 TLR4
3 paracoccidioidomycosis 31.2 IFNG IL10 IL4 TLR2 TLR4 TNF
4 adiaspiromycosis 11.1
5 allescheriosis 11.1
6 blastomycosis 11.1
7 phaeohyphomycosis 11.1
8 histoplasmosis 11.1
9 candidiasis, familial, 2 10.5 CARD9 CLEC7A
10 cow milk allergy 10.5 IL10 TNF
11 subcutaneous mycosis 10.5 CARD9 CLEC7A
12 trichuriasis 10.5 IL10 TNF
13 transient hypogammaglobulinemia 10.5 IL10 TNF
14 mucocutaneous leishmaniasis 10.5 IL10 TNF
15 idiopathic achalasia 10.5 IL10 TNF
16 multifocal choroiditis 10.5 IL10 TNF
17 punctate inner choroidopathy 10.5 IL10 TNF
18 retinitis pigmentosa 22 10.5 IL10 IL4
19 cephalosporin allergy 10.4 IFNG IL10
20 miliary tuberculosis 10.4 IFNG TNF
21 autoimmune myocarditis 10.4 IFNG TNF
22 chronic beryllium disease 10.4 IFNG TNF
23 b-cell growth factor 10.4 IFNG IL4
24 penicillin allergy 10.4 IFNG IL4
25 crustacean allergy 10.4 IFNG IL4
26 atopic keratoconjunctivitis 10.4 IFNG IL4
27 pouchitis 10.4 IL10 TLR4
28 rheumatic heart disease 10.3 IL10 IL4 TNF
29 nose disease 10.3 IL10 IL4 TNF
30 rubella 10.3 IL10 IL4 TNF
31 parasitic helminthiasis infectious disease 10.3 IL10 IL4 TNF
32 uveal disease 10.3 IL10 IL17A TNF
33 tropical endomyocardial fibrosis 10.3 IL10 IL4 TNF
34 endomyocardial fibrosis 10.3 IL10 IL4 TNF
35 respiratory allergy 10.3 IL10 IL17A IL4
36 variola major 10.3 IFNG TLR4
37 autoimmune atherosclerosis 10.3 HSPD1 IL10
38 salpingitis 10.3 HSPD1 TNF
39 vulvovaginitis 10.3 HSPD1 IL10
40 tungiasis 10.3 IL10 IL4 TNF
41 dengue hemorrhagic fever 10.3 IFNG IL10 TNF
42 hemophagocytic lymphohistiocytosis 10.3 IFNG IL10 TNF
43 hepatitis a 10.3 IFNG IL10 TNF
44 plasmodium falciparum malaria 10.3 IFNG IL10 TNF
45 human immunodeficiency virus infectious disease 10.3 IFNG IL10 TNF
46 ige responsiveness, atopic 10.3 IFNG IL10 IL4
47 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.3 IFNG IL10 IL4
48 allergic rhinitis 10.3 IFNG IL10 IL4
49 mucormycosis 10.3 CSF2 IFNG
50 chromoblastomycosis 10.3 CARD9 CLEC7A IL4

Graphical network of the top 20 diseases related to Primary Systemic Mycosis:



Diseases related to Primary Systemic Mycosis

Symptoms & Phenotypes for Primary Systemic Mycosis

GenomeRNAi Phenotypes related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

27 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.99 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.99 CLEC7A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.99 CLEC7A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.99 CLEC7A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.99 IL10 TLR4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.99 RHAG TLR4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.99 CLEC7A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.99 RHAG
9 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.99 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.99 CLEC7A IL10 RHAG TLR4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.99 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.99 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.99 CLEC7A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.99 CLEC7A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.99 CLEC7A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.99 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.99 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.99 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.99 CLEC7A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.99 TLR4
21 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.99 RHAG
22 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.99 CLEC7A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.99 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.99 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.99 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.99 IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.99 CLEC7A IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.99 IL10
29 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.99 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.99 CLEC7A
31 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.99 IL10
32 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.99 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.99 IL10 RHAG
34 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.99 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.99 CLEC7A
36 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.99 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.99 IL10
38 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.99 IL10
39 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.99 CLEC7A
40 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.99 RHAG

MGI Mouse Phenotypes related to Primary Systemic Mycosis:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.32 CARD9 CLEC7A CSF2 CYP51A1 IFNG IL10
2 hematopoietic system MP:0005397 10.3 CARD9 CLEC7A CSF2 IFNG IL10 IL17A
3 growth/size/body region MP:0005378 10.28 CSF2 CYP51A1 HSPD1 IFNG IL10 IL17A
4 immune system MP:0005387 10.27 CARD9 CLEC7A CSF2 CYP51A1 IFNG IL10
5 mortality/aging MP:0010768 10.21 CLEC7A CSF2 CYP51A1 HSPD1 IFNG IL10
6 digestive/alimentary MP:0005381 10.2 CLEC7A CYP51A1 IFNG IL10 IL17A IL4
7 cardiovascular system MP:0005385 10.17 CSF2 CYP51A1 IFNG IL10 IL1B TLR2
8 craniofacial MP:0005382 10.16 CSF2 CYP51A1 IFNG IL10 IL17A IL1B
9 integument MP:0010771 10.08 CSF2 IFNG IL10 IL1B IL4 TLR2
10 nervous system MP:0003631 10.02 CSF2 ERC2 HSPD1 IFNG IL10 IL1B
11 muscle MP:0005369 9.95 CYP51A1 HSPD1 IFNG IL10 TLR2 TLR4
12 liver/biliary system MP:0005370 9.93 IFNG IL10 IL4 TLR2 TLR4 TNF
13 neoplasm MP:0002006 9.91 CSF2 IFNG IL10 IL1B TLR2 TLR4
14 no phenotypic analysis MP:0003012 9.73 CYP51A1 IFNG IL10 IL17A IL4 TNF
15 renal/urinary system MP:0005367 9.63 CSF2 IFNG IL17A IL4 TLR2 TLR4
16 respiratory system MP:0005388 9.61 CLEC7A CSF2 IFNG IL10 IL17A IL4
17 skeleton MP:0005390 9.32 CSF2 CYP51A1 IFNG IL10 IL17A IL1B

Drugs & Therapeutics for Primary Systemic Mycosis

Search Clinical Trials , NIH Clinical Center for Primary Systemic Mycosis

Genetic Tests for Primary Systemic Mycosis

Anatomical Context for Primary Systemic Mycosis

MalaCards organs/tissues related to Primary Systemic Mycosis:

42
T Cells, Skin, Bone, Lymph Node, Eye, Prostate, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Primary Systemic Mycosis:

20
Human Body

Publications for Primary Systemic Mycosis

Variations for Primary Systemic Mycosis

Expression for Primary Systemic Mycosis

Search GEO for disease gene expression data for Primary Systemic Mycosis.

Pathways for Primary Systemic Mycosis

Pathways related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CARD9 CLEC7A CSF2 IFNG IL10 IL17A
2
Show member pathways
13.65 CSF2 IFNG IL10 IL17A IL1B IL4
3
Show member pathways
13.42 CSF2 IL10 IL17A IL1B IL4 TLR2
4
Show member pathways
13.36 CSF2 IFNG IL10 IL17A IL1B IL4
5
Show member pathways
13.27 CSF2 IL10 IL17A IL1B IL4 TNF
6
Show member pathways
13.19 IFNG IL1B IL4 TLR2 TLR4 TNF
7
Show member pathways
13.13 CARD9 IFNG IL10 IL1B TLR2 TLR4
8
Show member pathways
12.93 CSF2 IL1B TLR2 TLR4 TNF
9
Show member pathways
12.92 HSPD1 IFNG IL10 IL17A IL1B IL4
10
Show member pathways
12.63 CSF2 IFNG IL10 IL17A IL1B IL4
11
Show member pathways
12.63 IFNG IL10 IL17A IL1B IL4 TLR2
12
Show member pathways
12.62 IFNG IL10 IL17A IL1B TNF
13
Show member pathways
12.6 IFNG IL10 IL4 TNF
14 12.57 CARD9 IFNG IL10 IL17A IL1B IL4
15
Show member pathways
12.5 CSF2 IFNG IL4 TNF
16
Show member pathways
12.41 CSF2 IFNG IL17A IL1B IL4 TLR2
17
Show member pathways
12.39 CSF2 IFNG IL10 IL4
18
Show member pathways
12.34 IFNG IL1B IL4 TNF
19
Show member pathways
12.33 IFNG IL10 IL1B IL4 TLR2 TLR4
20
Show member pathways
12.32 IFNG IL10 IL17A IL1B IL4 TNF
21
Show member pathways
12.31 IFNG IL1B TLR4 TNF
22
Show member pathways
12.28 CARD9 CLEC7A IL10 IL1B TNF
23
Show member pathways
12.28 IFNG IL1B IL4 TLR2 TLR4 TNF
24
Show member pathways
12.24 IFNG IL1B TLR4 TNF
25 12.21 IFNG TLR2 TLR4 TNF
26 12.21 HSPD1 IL10 IL1B TNF
27
Show member pathways
12.1 IFNG IL10 IL17A IL1B IL4
28 12.1 IFNG IL1B IL4 TLR4 TNF
29 12.09 CSF2 IFNG IL10 IL4 TNF
30
Show member pathways
12.09 IFNG IL10 IL17A IL1B TLR2 TLR4
31 12.07 IL10 IL17A IL1B IL4 TNF
32 12.02 IFNG IL1B TNF
33
Show member pathways
12.01 IL1B TLR2 TLR4
34
Show member pathways
11.96 IFNG IL1B IL4
35 11.96 CSF2 IL1B IL4 TNF
36 11.95 CSF2 IL1B TNF
37 11.9 IL1B TLR4 TNF
38 11.9 CSF2 IFNG IL1B TLR4
39 11.89 CSF2 IFNG IL10 IL1B TLR2 TLR4
40
Show member pathways
11.87 CSF2 IL17A TLR4
41 11.86 CSF2 IFNG IL10 IL1B TNF
42 11.86 IFNG IL10 IL17A IL1B IL4 TNF
43
Show member pathways
11.84 CSF2 IFNG IL4 TNF
44 11.84 IL10 IL1B TLR4 TNF
45 11.82 CLEC7A TLR2 TLR4
46 11.82 CSF2 IFNG IL17A IL1B TLR2 TLR4
47 11.81 CSF2 IFNG IL4
48 11.75 CSF2 IL1B IL4 TNF
49
Show member pathways
11.75 CSF2 IFNG IL1B TNF
50 11.71 HSPD1 IL1B TLR2 TLR4 TNF

GO Terms for Primary Systemic Mycosis

Cellular components related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 CSF2 HSPD1 IFNG IL10 IL17A IL1B
2 lipopolysaccharide receptor complex GO:0046696 8.96 HSPD1 TLR4

Biological processes related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 CARD9 IL1B TLR4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.99 CSF2 IL10 IL17A IL1B IL4 TNF
3 regulation of signaling receptor activity GO:0010469 9.98 CSF2 IFNG IL10 IL17A IL1B IL4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 IL1B TLR2 TLR4 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.96 CSF2 IL10 IL1B TLR4 TNF
6 positive regulation of gene expression GO:0010628 9.95 CSF2 IFNG IL1B IL4 TLR2 TLR4
7 activation of MAPK activity GO:0000187 9.92 IL1B TLR4 TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL10 IL1B TNF
9 positive regulation of JNK cascade GO:0046330 9.91 CARD9 IL1B TLR4 TNF
10 defense response to Gram-positive bacterium GO:0050830 9.9 CARD9 TLR2 TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 CSF2 IFNG IL4
12 regulation of insulin secretion GO:0050796 9.88 IFNG IL1B TNF
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.87 CARD9 TLR4 TNF
14 response to lipopolysaccharide GO:0032496 9.87 IL10 IL1B TLR2 TLR4
15 positive regulation of tumor necrosis factor production GO:0032760 9.86 CARD9 TLR2 TLR4
16 T cell activation GO:0042110 9.86 CLEC7A HSPD1 IL4
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL1B TLR2 TLR4 TNF
18 positive regulation of interferon-gamma production GO:0032729 9.84 HSPD1 IL1B TLR4 TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 CSF2 IL1B TNF
20 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.83 HSPD1 TLR2 TLR4
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL1B TLR4 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.82 IL10 TLR4 TNF
23 positive regulation of interleukin-10 production GO:0032733 9.8 HSPD1 TLR2 TLR4
24 positive regulation of osteoclast differentiation GO:0045672 9.8 IFNG IL17A TNF
25 inflammatory response GO:0006954 9.8 CLEC7A IL10 IL17A IL1B TLR2 TLR4
26 positive regulation of chemokine production GO:0032722 9.79 TLR2 TLR4 TNF
27 positive regulation of macrophage activation GO:0043032 9.78 HSPD1 IL10 TLR4
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR2 TLR4 TNF
29 positive regulation of inflammatory response GO:0050729 9.77 TLR2 TLR4 TNF
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 IFNG IL1B TNF
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 IL1B TNF
32 defense response to protozoan GO:0042832 9.75 CLEC7A IL10
33 positive regulation of stress-activated MAPK cascade GO:0032874 9.75 CARD9 TLR4
34 microglial cell activation GO:0001774 9.75 TLR2 TNF
35 myeloid dendritic cell differentiation GO:0043011 9.75 CSF2 IL4
36 negative regulation of lipid catabolic process GO:0050995 9.75 IL1B TNF
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.74 IL17A TLR4
38 positive regulation of glial cell proliferation GO:0060252 9.74 IL1B TNF
39 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.74 IL1B TNF
40 negative regulation of growth of symbiont in host GO:0044130 9.74 IL10 TNF
41 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
42 response to drug GO:0042493 9.73 CARD9 IL10
43 positive regulation of interferon-alpha production GO:0032727 9.73 HSPD1 TLR4
44 regulation of cytokine secretion GO:0050707 9.73 TLR2 TLR4
45 dendritic cell differentiation GO:0097028 9.73 CSF2 IL4
46 I-kappaB phosphorylation GO:0007252 9.73 TLR2 TLR4
47 negative regulation of interleukin-17 production GO:0032700 9.72 IFNG TLR4
48 positive regulation of podosome assembly GO:0071803 9.72 CSF2 TNF
49 response to molecule of bacterial origin GO:0002237 9.72 IL10 TLR2
50 response to organic substance GO:0010033 9.72 IL10 TNF

Molecular functions related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling pattern recognition receptor activity GO:0008329 9.26 CLEC7A TLR2
2 cytokine activity GO:0005125 9.17 CSF2 IFNG IL10 IL17A IL1B IL4
3 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
4 lipopolysaccharide binding GO:0001530 9.13 HSPD1 TLR2 TLR4

Sources for Primary Systemic Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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