MCID: PRM026
MIFTS: 34

Primary Systemic Mycosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Primary Systemic Mycosis

MalaCards integrated aliases for Primary Systemic Mycosis:

Name: Primary Systemic Mycosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050292

Summaries for Primary Systemic Mycosis

Disease Ontology : 12 A systemic mycosis that results in infection located in human body, has material basis in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

MalaCards based summary : Primary Systemic Mycosis is related to phaeohyphomycosis and histoplasmosis. An important gene associated with Primary Systemic Mycosis is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include human body, lung and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Primary Systemic Mycosis

Diseases in the Rare Mycosis family:

Primary Systemic Mycosis

Diseases related to Primary Systemic Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 667)
# Related Disease Score Top Affiliating Genes
1 phaeohyphomycosis 32.0 CLEC7A CLEC6A CLEC4E CBSL CARD9
2 histoplasmosis 31.6 TNFRSF1B TNF IFNG CLEC7A CD8A CD40LG
3 coccidioidomycosis 31.6 IL17A CLEC7A CLEC6A CLEC4E CD40LG CD4
4 paracoccidioidomycosis 31.5 TNF TLR2 IL6 IL4 IL10 IFNG
5 sporotrichosis 31.4 TNF IL10 IFNG EMB CLEC7A CD40LG
6 blastomycosis 31.1 TNF IL17A CLEC7A CLEC6A CLEC4E CD8A
7 adiaspiromycosis 11.3
8 allescheriosis 11.3
9 riedel's fibrosing thyroiditis 10.6 CD40LG CD4
10 punctate inner choroidopathy 10.6 TNF IL10
11 penicilliosis 10.6 CLEC7A CD4 CARD9
12 multifocal choroiditis 10.6 TNF IL10
13 ventilation pneumonitis 10.6 CD8A CD4
14 necrotic uveal melanoma 10.5 IFNG CD8A
15 glossopharyngeal nerve paralysis 10.5 TNFRSF1B CD40LG
16 pustulosis palmaris et plantaris 10.5 TNF CD40LG CCR6
17 spongiotic dermatitis 10.5 CD8A CD4 CCR6
18 intestinal tuberculosis 10.5 TNF IFNG CD4
19 diffuse infiltrative lymphocytosis syndrome 10.5 CD8A CD4
20 external pathological resorption 10.5 TNF IL6
21 autoimmune lymphoproliferative syndrome, type iia 10.5 CD8A CD4
22 polyarticular juvenile idiopathic arthritis 10.5 TNF IFNG
23 diabetes mellitus, insulin-dependent, 23 10.5 TNF CD8A CD4
24 cork-handlers' disease 10.5 CD8A CD40LG CD4
25 staphylococcal toxic shock syndrome 10.5 TNF IFNG
26 syphilitic meningitis 10.5 CD8A CD40LG CD4
27 autoimmune polyendocrine syndrome 10.5 IL17A IL10 CCR6
28 autoimmune myocarditis 10.5 TNF IFNG
29 autoimmune disease of skin and connective tissue 10.5 CD40LG CD4 CCR6
30 transient arthritis 10.5 IL17A CD40LG CD4
31 meningovascular neurosyphilis 10.5 IL17A CD40LG CD4
32 early yaws 10.5 CD8A CD40LG CD4
33 chromosome 14q11-q22 deletion syndrome 10.5 CD8A CD4
34 scorpion envenomation 10.5 TNF IL6
35 t-cell adult acute lymphocytic leukemia 10.5 CD8A CD4 CCR6
36 adult acute lymphocytic leukemia 10.5 CD8A CD4 CCR6
37 transient hypogammaglobulinemia 10.5 TNF IL10 CD40LG
38 trichuriasis 10.5 TNF IL10 CCR6
39 farmer's lung 10.5 TNF CD8A CD4
40 autoimmune glomerulonephritis 10.5 CD8A CD4 CCR6
41 tertiary syphilis 10.5 CD8A CD40LG CD4
42 acute retinal necrosis syndrome 10.5 CD8A CD40LG CD4
43 tropical endomyocardial fibrosis 10.5 TNF IL4 IL10
44 endomyocardial fibrosis 10.5 TNF IL4 IL10
45 west nile encephalitis 10.5 CD8A CD40LG CD4
46 cryptogenic organizing pneumonia 10.5 TNF CD8A CD4
47 cerebritis 10.5 CD8A CD40LG CD4
48 parotid disease 10.5 CD8A CD40LG CD4
49 bullous skin disease 10.5 CD40LG CD4 CCR6
50 secondary syphilis 10.5 CD8A CD40LG CD4

Graphical network of the top 20 diseases related to Primary Systemic Mycosis:



Diseases related to Primary Systemic Mycosis

Symptoms & Phenotypes for Primary Systemic Mycosis

MGI Mouse Phenotypes related to Primary Systemic Mycosis:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.49 CARD9 CBSL CCR6 CD4 CD40LG CD8A
2 immune system MP:0005387 10.46 CARD9 CBSL CCR6 CD4 CD40LG CD8A
3 homeostasis/metabolism MP:0005376 10.43 CARD9 CBSL CCR6 CD4 CD40LG CLEC4E
4 mortality/aging MP:0010768 10.41 CBSL CD4 CD40LG CD8A CLEC4E CLEC6A
5 cellular MP:0005384 10.39 CBSL CD4 CD40LG CD8A CSF2 HSPD1
6 endocrine/exocrine gland MP:0005379 10.39 CBSL CD4 CD40LG CD8A CSF2 EMB
7 cardiovascular system MP:0005385 10.36 CBSL CCR6 CD40LG CLEC4E CSF2 EMB
8 integument MP:0010771 10.31 CBSL CD4 CD40LG CD8A CSF2 IFNG
9 digestive/alimentary MP:0005381 10.26 CD4 CLEC7A IFNG IL10 IL17A IL4
10 nervous system MP:0003631 10.21 CBSL CCR6 CD4 CD40LG CD8A CSF2
11 craniofacial MP:0005382 10.17 CBSL CSF2 IFNG IL10 IL17A IL4
12 liver/biliary system MP:0005370 10.13 CBSL EMB IFNG IL10 IL4 IL6
13 muscle MP:0005369 10.03 CBSL HSPD1 IFNG IL10 IL6 TLR2
14 renal/urinary system MP:0005367 10 CBSL CD40LG CD8A CLEC6A CSF2 IFNG
15 neoplasm MP:0002006 9.95 CSF2 IFNG IL10 IL6 TLR2 TNF
16 no phenotypic analysis MP:0003012 9.92 CD4 CLEC4E CLEC6A IFNG IL10 IL17A
17 reproductive system MP:0005389 9.85 CBSL CD40LG CSF2 EMB HSPD1 IFNG
18 respiratory system MP:0005388 9.7 CBSL CLEC7A CSF2 IFNG IL10 IL17A
19 skeleton MP:0005390 9.32 CD40LG CSF2 IFNG IL10 IL17A IL4

Drugs & Therapeutics for Primary Systemic Mycosis

Search Clinical Trials , NIH Clinical Center for Primary Systemic Mycosis

Genetic Tests for Primary Systemic Mycosis

Anatomical Context for Primary Systemic Mycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Primary Systemic Mycosis:

19
Human Body

MalaCards organs/tissues related to Primary Systemic Mycosis:

40
Lung, Bone, T Cells, Skin, B Cells, Eye, Thyroid

Publications for Primary Systemic Mycosis

Articles related to Primary Systemic Mycosis:

# Title Authors PMID Year
1
Histoplasmosis in children. 61
19879506 2009

Variations for Primary Systemic Mycosis

Expression for Primary Systemic Mycosis

Search GEO for disease gene expression data for Primary Systemic Mycosis.

Pathways for Primary Systemic Mycosis

Pathways related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 TNFRSF1B TNF TLR2 IL6 IL4 IL17A
2
Show member pathways
13.87 TNFRSF1B TNF IL6 IL4 IL17A IL10
3
Show member pathways
13.75 TNFRSF1B TNF IL6 IL4 IL17A IL10
4
Show member pathways
13.58 TNFRSF1B TNF IL6 IL4 IL17A IL10
5
Show member pathways
13.5 TNFRSF1B TNF TLR2 IL6 IL4 IL17A
6
Show member pathways
13.45 TNFRSF1B TNF IL6 IL4 IL17A IL10
7
Show member pathways
13.39 TNFRSF1B TNF IL6 IL4 IL17A IL10
8
Show member pathways
12.98 TNFRSF1B TNF TLR2 IL6 CSF2 CD4
9
Show member pathways
12.9 TNF IL6 IL4 IL17A IL10 IFNG
10 12.83 TNF TLR2 IL6 IFNG CARD9
11
Show member pathways
12.75 TNFRSF1B TNF IL4 IL10 IFNG CD40LG
12
Show member pathways
12.74 TNFRSF1B TNF TLR2 IL6 CD40LG
13
Show member pathways
12.72 TNF TLR2 IL6 IL4 IL17A IL10
14
Show member pathways
12.71 TNFRSF1B TNF IFNG CD40LG CD4
15
Show member pathways
12.69 TNF IL6 IL17A IL10 IFNG CD4
16 12.54 TNFRSF1B TNF TLR2 IL4 IL17A IL10
17
Show member pathways
12.48 TNF TLR2 IL6 IL4 IL17A IFNG
18
Show member pathways
12.45 IL6 IL4 IL10 IFNG CSF2
19
Show member pathways
12.42 TNFRSF1B TNF IL6 IL10 CCR6
20
Show member pathways
12.39 TNF TLR2 IL4 IL10 IFNG CD40LG
21 12.37 TNF IL6 CSF2 CD4
22
Show member pathways
12.37 TNF IL6 IL4 IL17A IL10 IFNG
23
Show member pathways
12.36 TNF IL6 IL4 IFNG
24
Show member pathways
12.33 TNF IL6 IL10 CLEC7A CLEC6A CLEC4E
25
Show member pathways
12.28 TNF TLR2 IL6 IL4 IFNG
26 12.24 TNF TLR2 IL6 IFNG
27
Show member pathways
12.24 TNF TLR2 IL6 IL4 IL17A IL10
28 12.22 TNF IL6 IL10 HSPD1
29
Show member pathways
12.18 TNF TLR2 IL6 IL17A IL10 IFNG
30 12.17 TNF TLR2 IL6 IL10 IFNG HSPD1
31
Show member pathways
12.15 TNF TLR2 IL6 IL4 IFNG HSPD1
32 12.14 TNFRSF1B TNF IL6 IL4 IL17A IL10
33 12.08 TNF IL6 IL4 IFNG
34 12.08 TNF TLR2 IL6 IL10 IFNG CSF2
35 12.06 TNF IL6 IL4 CSF2 CD8A CD4
36
Show member pathways
12.05 IL4 IFNG CD8A CD4
37 12.04 TNFRSF1B TNF IL6 CSF2
38 12.03 TNF IL6 IL4 IL10 IFNG CSF2
39 12.01 TNF TLR2 IL6 IL17A IFNG CSF2
40 11.9 IL6 IL4 IFNG CSF2
41
Show member pathways
11.9 TNF IL4 IFNG CSF2 CD40LG
42 11.85 TNF IL6 IL10 IFNG CSF2 CD8A
43 11.82 IL6 IFNG CSF2
44
Show member pathways
11.81 TNF IL6 IFNG CSF2 CD40LG
45 11.8 TNF IL6 IL4 IL17A IL10 IFNG
46 11.79 TNF IL6 IL10
47
Show member pathways
11.77 TNFRSF1B TNF CD40LG
48 11.77 TNF IL6 IL4 CSF2
49 11.72 TNF TLR2 IL6 HSPD1
50 11.7 IL4 IL10 CD40LG

GO Terms for Primary Systemic Mycosis

Cellular components related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 TNFRSF1B TNF TLR2 HSPD1 EMB CLEC7A
2 extracellular space GO:0005615 9.91 TNF IL6 IL4 IL17A IL10 IFNG
3 extracellular region GO:0005576 9.85 TNFRSF1B TNF IL6 IL4 IL17A IL10
4 membrane raft GO:0045121 9.67 TNFRSF1B TNF TLR2 CD4
5 cell surface GO:0009986 9.5 TNF TLR2 HSPD1 CLEC7A CD40LG CD4
6 external side of plasma membrane GO:0009897 9.1 TNF IL17A CD8A CD40LG CD4 CCR6

Biological processes related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.1 TLR2 CLEC7A CLEC6A CLEC4E CD8A CD4
2 positive regulation of gene expression GO:0010628 10.02 TNF TLR2 IL6 IL4 IFNG CSF2
3 cell surface receptor signaling pathway GO:0007166 10.01 TNFRSF1B IFNG CD8A CD4
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 TNF CLEC6A CD4 CARD9
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TNF TLR2 IL6 CD40LG
6 cellular response to lipopolysaccharide GO:0071222 9.93 TNFRSF1B TNF IL6 IL10 CSF2
7 defense response to Gram-positive bacterium GO:0050830 9.91 TNF TLR2 IL6 CARD9
8 B cell differentiation GO:0030183 9.89 IL4 IL10 CD40LG
9 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
10 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.85 TNF CLEC7A CARD9
11 positive regulation of phagocytosis GO:0050766 9.84 TNF IFNG CLEC7A
12 extrinsic apoptotic signaling pathway GO:0097191 9.84 TNFRSF1B TNF IFNG
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF IFNG CLEC7A
14 positive regulation of T cell proliferation GO:0042102 9.83 IL6 IL4 CD40LG CD4
15 positive regulation of protein complex assembly GO:0031334 9.82 TNF IFNG CLEC7A
16 B cell proliferation GO:0042100 9.81 IL10 HSPD1 CD40LG
17 positive regulation of interleukin-6 secretion GO:2000778 9.81 TNF TLR2 IL17A
18 humoral immune response GO:0006959 9.81 TNF IL6 IFNG CCR6
19 positive regulation of JAK-STAT cascade GO:0046427 9.79 TNF IL6 IL10
20 microglial cell activation GO:0001774 9.79 TNF TLR2 IFNG
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 TNF IL6 IL4 IFNG CSF2
22 positive regulation of interleukin-10 production GO:0032733 9.76 TLR2 HSPD1 CD40LG
23 inflammatory response GO:0006954 9.76 TNFRSF1B TNF TLR2 IL6 IL17A IL10
24 positive regulation of osteoclast differentiation GO:0045672 9.75 TNF IL17A IFNG
25 positive regulation of chemokine production GO:0032722 9.74 TNF TLR2 IL6
26 positive regulation of cytokine secretion GO:0050715 9.73 TNF IL10 CLEC6A CLEC4E
27 positive regulation of chemokine biosynthetic process GO:0045080 9.72 TNF IFNG
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 TNFRSF1B TNF IFNG
29 positive regulation of interleukin-6 production GO:0032755 9.72 TNF TLR2 IL6 HSPD1 CARD9
30 pattern recognition receptor signaling pathway GO:0002221 9.71 CLEC7A CLEC4E
31 negative regulation of amyloid-beta clearance GO:1900222 9.71 TNF IFNG
32 regulation of neuroinflammatory response GO:0150077 9.71 TNFRSF1B IL6
33 positive regulation of interleukin-12 production GO:0032735 9.71 TLR2 IFNG HSPD1 CD40LG
34 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.7 IL4 IL10
35 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.7 CSF2 CD4
36 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
37 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
38 positive regulation of killing of cells of other organism GO:0051712 9.69 IFNG CLEC7A
39 response to peptidoglycan GO:0032494 9.68 IL6 CARD9
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 TNF IL10
41 neuroinflammatory response GO:0150076 9.68 IL4 IFNG
42 regulation of immunoglobulin secretion GO:0051023 9.67 TNF CD40LG
43 type 2 immune response GO:0042092 9.67 IL4 IL10
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL4 IL10 IFNG
45 positive regulation of cellular respiration GO:1901857 9.65 IL4 IFNG
46 regulation of isotype switching GO:0045191 9.65 IL4 IL10
47 T cell activation GO:0042110 9.65 IL4 HSPD1 CLEC7A CD8A CD4
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IFNG
49 positive regulation of interleukin-23 production GO:0032747 9.63 IL17A IFNG CSF2
50 receptor biosynthetic process GO:0032800 9.62 TNF IL10

Molecular functions related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.46 TLR2 CLEC4E CD4 CCR6
2 signaling pattern recognition receptor activity GO:0008329 9.26 TLR2 CLEC7A
3 growth factor activity GO:0008083 9.26 IL6 IL4 IL10 CSF2
4 cytokine activity GO:0005125 9.23 TNF IL6 IL4 IL17A IL10 IFNG

Sources for Primary Systemic Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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