MCID: PRM026
MIFTS: 31

Primary Systemic Mycosis

Categories: Infectious diseases

Aliases & Classifications for Primary Systemic Mycosis

MalaCards integrated aliases for Primary Systemic Mycosis:

Name: Primary Systemic Mycosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050292

Summaries for Primary Systemic Mycosis

Disease Ontology : 12 A systemic mycosis that results in infection located in human body, has material basis in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

MalaCards based summary : Primary Systemic Mycosis is related to coccidioidomycosis and paracoccidioidomycosis. An important gene associated with Primary Systemic Mycosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include human body, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Primary Systemic Mycosis

Diseases related to Primary Systemic Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 coccidioidomycosis 31.2 CARD9 CD40LG CLEC7A CYP51A1
2 paracoccidioidomycosis 30.5 IFNG IL10 IL4 TLR2 TNF
3 sporotrichosis 30.2 CALM1 CALM2 CALM3 CD40LG IFNG IL10
4 adiaspiromycosis 10.9
5 allescheriosis 10.9
6 blastomycosis 10.9
7 phaeohyphomycosis 10.9
8 histoplasmosis 10.9
9 punctate inner choroidopathy 10.9 IL10 TNF
10 microscopic polyangiitis 10.8 IL10 TNF
11 multifocal choroiditis 10.8 IL10 TNF
12 transient hypogammaglobulinemia 10.8 IL10 TNF
13 ross river fever 10.7 CD40LG IL10
14 encephalitozoonosis 10.6 CD40LG TNF
15 subcutaneous mycosis 10.6 CARD9 CLEC7A
16 miller fisher syndrome 10.6 CD40LG TNF
17 idiopathic achalasia 10.6 IL10 TNF
18 necrotizing ulcerative gingivitis 10.6 CD40LG IL10
19 acute dacryocystitis 10.5 CALM1 CALM2 CALM3
20 pneumocystosis 10.5 CD40LG CLEC7A TNF
21 external ear disease 10.5 CALM1 CALM2 CALM3
22 long qt syndrome 15 10.5 CALM1 CALM2 CALM3
23 otitis externa 10.5 CALM1 CALM2 CALM3
24 otomycosis 10.5 CALM1 CALM2 CALM3
25 spontaneous ocular nystagmus 10.5 CALM1 CALM2 CALM3
26 deafness, autosomal recessive 44 10.5 CALM1 CALM2 CALM3
27 dystonia 24 10.5 CALM1 CALM2 CALM3
28 haemophilus influenzae 10.5 CLEC7A TLR2 TNF
29 triosephosphate isomerase deficiency 10.5 CALM1 CALM2 CALM3
30 staphylococcal toxic shock syndrome 10.5 IFNG TNF
31 leber congenital amaurosis 2 10.5 CALM1 CALM2 CALM3
32 mycobacterium abscessus 10.5 CLEC7A TLR2 TNF
33 autoimmune myocarditis 10.5 IFNG TNF
34 clear cell acanthoma 10.5 CALM1 CALM2 CALM3
35 cardiomyopathy, dilated, 1a 10.5 CALM1 CALM2 CALM3
36 cardiomyopathy, dilated, 1p 10.5 CALM1 CALM2 CALM3
37 churg-strauss syndrome 10.5 CD40LG IL10 TNF
38 deafness, autosomal dominant 2a 10.5 CALM1 CALM2 CALM3
39 hemorrhagic fever with renal syndrome 10.5 CD40LG IL10 TNF
40 idiopathic neutropenia 10.5 CD40LG IL10 TNF
41 pertussis 10.5 CALM1 IL10 TNF
42 tropical endomyocardial fibrosis 10.5 IL10 IL4 TNF
43 trichuriasis 10.5 IL10 TNF
44 primary cutaneous amyloidosis 10.4 CALM1 CALM2 CALM3
45 tungiasis 10.4 IL10 IL4 TNF
46 endomyocardial fibrosis 10.4 IL10 IL4 TNF
47 retinitis pigmentosa 22 10.4 IL10 IL4
48 chronic beryllium disease 10.4 IFNG TNF
49 mucocutaneous leishmaniasis 10.4 IL10 TNF
50 aphthous stomatitis 10.4 IL10 IL4 TNF

Graphical network of the top 20 diseases related to Primary Systemic Mycosis:



Diseases related to Primary Systemic Mycosis

Symptoms & Phenotypes for Primary Systemic Mycosis

GenomeRNAi Phenotypes related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.3 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.3 CLEC7A CALM2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.3 CLEC7A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.3 CLEC7A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.3 IL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.3 RHAG
7 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.3 CLEC7A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.3 RHAG
9 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.3 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.3 CLEC7A RHAG CALM2 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.3 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.3 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.3 CLEC7A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.3 CLEC7A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.3 CLEC7A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.3 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.3 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.3 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.3 CLEC7A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-182 10.3 RHAG
21 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.3 CLEC7A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.3 IL10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.3 CLEC7A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.3 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.3 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.3 IL10 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.3 IL10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.3 CLEC7A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.3 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.3 IL10
31 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.3 CLEC7A
32 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.3 IL10
33 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.3 CLEC7A
34 Increased shRNA abundance (Z-score > 2) GR00366-A-80 10.3 IL10
35 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10.3 IL10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.3 CALM2 IL10
37 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.3 CLEC7A
38 Increased shRNA abundance (Z-score > 2) GR00366-A-97 10.3 RHAG
39 Reduced mammosphere formation GR00396-S 9.1 IL17A CLEC7A CYP51A1 CALM1 CALM2 CALM3

MGI Mouse Phenotypes related to Primary Systemic Mycosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 IL4 IFNG RHAG TLR2 IL10 CARD9
2 homeostasis/metabolism MP:0005376 10.06 IL4 IFNG RHAG TLR2 IL10 CARD9
3 digestive/alimentary MP:0005381 10.01 IFNG TLR2 IL10 TNF IL17A CLEC7A
4 immune system MP:0005387 9.96 IL4 IFNG TLR2 IL10 CARD9 TNF
5 craniofacial MP:0005382 9.91 CYP51A1 IL4 IFNG IL10 TNF IL17A
6 no phenotypic analysis MP:0003012 9.63 CYP51A1 IL4 IFNG IL10 TNF IL17A
7 respiratory system MP:0005388 9.5 IL4 IFNG TLR2 IL10 TNF IL17A
8 skeleton MP:0005390 9.23 CYP51A1 IL4 IFNG TLR2 IL10 CD40LG

Drugs & Therapeutics for Primary Systemic Mycosis

Search Clinical Trials , NIH Clinical Center for Primary Systemic Mycosis

Genetic Tests for Primary Systemic Mycosis

Anatomical Context for Primary Systemic Mycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Primary Systemic Mycosis:

19
Human Body

Publications for Primary Systemic Mycosis

Variations for Primary Systemic Mycosis

Expression for Primary Systemic Mycosis

Search GEO for disease gene expression data for Primary Systemic Mycosis.

Pathways for Primary Systemic Mycosis

Pathways related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CALM1 CALM2 CALM3 CARD9 CD40LG CLEC7A
2
Show member pathways
13.66 CALM1 CALM2 CALM3 CD40LG IFNG IL10
3
Show member pathways
13.38 CD40LG IL10 IL17A IL4 TLR2 TNF
4
Show member pathways
13.33 CALM1 CALM2 CALM3 CD40LG IFNG IL10
5
Show member pathways
13 CARD9 IFNG IL10 TLR2 TNF
6
Show member pathways
12.92 CALM1 CALM2 CALM3 CD40LG TNF
7 12.85 CALM1 CALM2 CALM3 IFNG IL4
8
Show member pathways
12.8 CALM1 CALM2 CALM3 IFNG IL4 TLR2
9
Show member pathways
12.76 CALM1 CALM2 CALM3 CD40LG IFNG IL10
10
Show member pathways
12.72 CALM1 CALM2 CALM3 CD40LG TLR2 TNF
11
Show member pathways
12.67 IFNG IL10 IL17A IL4 TNF
12
Show member pathways
12.62 CALM1 CALM2 CALM3 IL4 TNF
13
Show member pathways
12.6 CALM1 CALM2 CALM3 TLR2 TNF
14
Show member pathways
12.58 IFNG IL10 IL17A TNF
15
Show member pathways
12.54 CALM1 CALM2 CALM3 IFNG IL4 TNF
16
Show member pathways
12.5 CALM1 CALM2 CALM3 TNF
17
Show member pathways
12.46 CALM1 CALM2 CALM3 CARD9 CLEC7A
18
Show member pathways
12.46 IFNG IL10 IL17A IL4 TLR2 TNF
19
Show member pathways
12.41 CALM1 CALM2 CALM3 CD40LG
20 12.37 CARD9 CD40LG IFNG IL10 IL17A IL4
21
Show member pathways
12.36 IFNG IL17A IL4 TLR2 TNF
22
Show member pathways
12.3 CALM1 CALM2 CALM3 IFNG TNF
23
Show member pathways
12.28 IFNG IL10 IL17A TLR2 TNF
24
Show member pathways
12.23 IFNG IL4 TLR2 TNF
25
Show member pathways
12.21 CD40LG IFNG IL10 IL4 TLR2 TNF
26
Show member pathways
12.17 CALM1 CALM2 CD40LG IFNG IL10 IL17A
27
Show member pathways
12.16 CALM1 CALM2 CALM3 TNF
28 12.13 CALM1 CALM2 CALM3 IFNG TNF
29
Show member pathways
12.1 CALM1 CALM2 CALM3 CARD9 CLEC7A IL10
30 12.07 CALM1 CALM2 CALM3
31
Show member pathways
12.05 CALM1 CALM2 CALM3 IFNG IL10 IL17A
32 12.03 IFNG IL10 IL4 TNF
33
Show member pathways
12.02 CALM1 CALM2 CALM3
34 12.02 IL10 IL17A IL4 TNF
35 12.01 IFNG IL4 TNF
36
Show member pathways
12 CALM1 CALM2 CALM3
37
Show member pathways
11.98 CALM1 CALM2 CALM3
38
Show member pathways
11.95 CALM1 CALM2 CALM3
39 11.93 CALM1 CALM2 CALM3
40 11.93 CALM1 CALM2 CALM3
41 11.93 IFNG IL10 TLR2 TNF
42
Show member pathways
11.91 CALM1 CALM2 CALM3
43 11.9 CALM1 CALM2 CALM3
44 11.9 IFNG IL17A TLR2 TNF
45
Show member pathways
11.88 CALM1 CALM2 CALM3
46
Show member pathways
11.88 CALM1 CALM2 CALM3
47 11.83 IFNG IL10 IL17A IL4 TNF
48
Show member pathways
11.81 CALM1 CALM2 CALM3
49
Show member pathways
11.8 CALM1 CALM2 CALM3
50
Show member pathways
11.79 CALM1 CALM2 CALM3

GO Terms for Primary Systemic Mycosis

Cellular components related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle pole GO:0000922 9.54 CALM1 CALM2 CALM3
2 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
3 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
4 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
5 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3
6 plasma membrane GO:0005886 10.02 CALM1 CALM2 CALM3 CARD9 CD40LG CLEC7A

Biological processes related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CD40LG IFNG IL10 IL17A IL4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.98 IL10 IL17A IL4 TNF
3 inflammatory response GO:0006954 9.91 CD40LG CLEC7A IL10 IL17A TLR2 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.85 CARD9 TLR2 TNF
5 B cell differentiation GO:0030183 9.85 CD40LG IL10 IL4
6 response to calcium ion GO:0051592 9.83 CALM1 CALM2 CALM3
7 positive regulation of interleukin-6 production GO:0032755 9.82 CARD9 TLR2 TNF
8 substantia nigra development GO:0021762 9.81 CALM1 CALM2 CALM3
9 regulation of cytokinesis GO:0032465 9.8 CALM1 CALM2 CALM3
10 regulation of heart rate GO:0002027 9.79 CALM1 CALM2 CALM3
11 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.78 CALM1 CALM2 CALM3
12 positive regulation of interleukin-12 production GO:0032735 9.77 CD40LG IFNG TLR2
13 positive regulation of protein autophosphorylation GO:0031954 9.76 CALM1 CALM2 CALM3
14 positive regulation of protein dephosphorylation GO:0035307 9.75 CALM1 CALM2 CALM3
15 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.74 CALM1 CALM2 CALM3
16 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.73 CALM1 CALM2 CALM3
17 regulation of cardiac muscle contraction GO:0055117 9.72 CALM1 CALM2 CALM3
18 positive regulation of osteoclast differentiation GO:0045672 9.71 IFNG IL17A TNF
19 defense response to protozoan GO:0042832 9.7 CLEC7A IL10
20 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.7 CALM1 CALM2 CALM3
21 immune response GO:0006955 9.7 CD40LG IFNG IL10 IL17A IL4 TLR2
22 positive regulation of chemokine production GO:0032722 9.69 TLR2 TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IFNG TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
25 response to molecule of bacterial origin GO:0002237 9.68 IL10 TLR2
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL10 TNF
27 endothelial cell apoptotic process GO:0072577 9.67 IL10 TNF
28 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL10 IL4
29 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.67 CALM1 CALM2 CALM3
30 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 IL10 TNF
31 type 2 immune response GO:0042092 9.66 IL10 IL4
32 positive regulation of interleukin-23 production GO:0032747 9.65 IFNG IL17A
33 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
34 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.65 CALM1 CALM2 CALM3
35 regulation of isotype switching GO:0045191 9.64 IL10 IL4
36 detection of calcium ion GO:0005513 9.63 CALM1 CALM2 CALM3
37 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IFNG TNF
39 positive regulation of vitamin D biosynthetic process GO:0060557 9.6 IFNG TNF
40 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.58 CALM1 CALM2 CALM3
41 positive regulation of protein serine/threonine kinase activity GO:0071902 9.56 CALM1 CALM2 CALM3 IFNG
42 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.54 CALM1 CALM2 CALM3
43 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.5 CALM1 CALM2 CALM3
44 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
45 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Primary Systemic Mycosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.76 CALM1 CALM2 CALM3 CARD9
2 ion channel binding GO:0044325 9.67 CALM1 CALM2 CALM3
3 disordered domain specific binding GO:0097718 9.58 CALM1 CALM2 CALM3
4 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
5 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
6 calcium channel inhibitor activity GO:0019855 9.48 CALM1 CALM2
7 signaling pattern recognition receptor activity GO:0008329 9.43 CLEC7A TLR2
8 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
9 cytokine activity GO:0005125 9.43 CD40LG IFNG IL10 IL17A IL4 TNF
10 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
11 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Primary Systemic Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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