Aliases & Classifications for Proctitis

MalaCards integrated aliases for Proctitis:

Name: Proctitis 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3127
ICD10 33 K62.89
MeSH 44 D011349
NCIt 50 C38011
SNOMED-CT 68 3951002
UMLS 73 C0033246

Summaries for Proctitis

Disease Ontology : 12 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding.

MalaCards based summary : Proctitis is related to radiation proctitis and ulcerative colitis, and has symptoms including rectal tenesmus An important gene associated with Proctitis is EPX (Eosinophil Peroxidase), and among its related pathways/superpathways are Selenium Micronutrient Network and Proteoglycans in cancer. The drugs Tacrolimus and Sucralfate have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and cervix.

Wikipedia : 76 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last 6�inches... more...

Related Diseases for Proctitis

Diseases related to Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 radiation proctitis 33.4 ENTPD1 FGF2 KDR LTF TNF
2 ulcerative colitis 31.0 CRP MPO TNF
3 inflammatory bowel disease 30.1 CRP EPX LTF MPO TNF
4 collagenous colitis 29.9 EPX MPO RNASE3
5 aseptic meningitis 29.9 LTF TNF
6 gastroenteritis 29.9 CRP RNASE3 TNF
7 ulcerative proctitis 12.6
8 colitis 10.7
9 lymphogranuloma venereum 10.5
10 chlamydia 10.5
11 prostate cancer 10.5
12 eosinophilic granuloma 10.3 EPX RNASE3
13 herpes simplex 10.3
14 eosinophil peroxidase deficiency 10.2 EPX MPO
15 inflammatory bowel disease 4 10.2 EPX RNASE3
16 conjunctival nevus 10.2 EPX RNASE3
17 cow milk allergy 10.2 RNASE3 TNF
18 eosinophilic gastroenteritis 10.2 EPX RNASE3
19 trichuriasis 10.2 RNASE3 TNF
20 autoimmune inner ear disease 10.2 MPO TNF
21 microscopic polyangiitis 10.2 MPO TNF
22 chronic rhinitis 10.2 EPX MPO
23 maxillary sinusitis 10.2 MPO RNASE3
24 urinary schistosomiasis 10.2 EPX RNASE3
25 drug reaction with eosinophilia and systemic symptoms 10.2 CRP TNF
26 anca-associated vasculitis 10.2 MPO TNF
27 salpingitis 10.2 CRP TNF
28 burns 10.2 CRP TNF
29 mononeuritis multiplex 10.2 CRP MPO
30 aortitis 10.2 CRP MPO
31 melancholia 10.2 CRP TNF
32 giant papillary conjunctivitis 10.2 LTF RNASE3
33 mediastinitis 10.2 CRP MPO
34 relapsing fever 10.2 CRP TNF
35 crohn's disease 10.2
36 cystitis 10.2
37 periodontosis 10.2 MPO TNF
38 central nervous system vasculitis 10.2 CRP TNF
39 granulocytopenia 10.2 MPO TNF
40 louse-borne relapsing fever 10.2 CRP TNF
41 haemophilus influenzae 10.2 LTF TNF
42 streptococcal meningitis 10.2 CRP TNF
43 tuberculous peritonitis 10.2 CRP TNF
44 rapidly progressive glomerulonephritis 10.2 CRP MPO
45 pulmonary aspergilloma 10.2 CRP MPO
46 rheumatoid vasculitis 10.2 LTF TNF
47 chronic maxillary sinusitis 10.2 MPO RNASE3
48 ischemic heart disease 10.2 CRP TNF
49 conjunctival disease 10.2 RNASE3 TNF
50 mycoplasma pneumoniae pneumonia 10.2 CRP TNF

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to Proctitis

Symptoms & Phenotypes for Proctitis

UMLS symptoms related to Proctitis:


rectal tenesmus

Drugs & Therapeutics for Proctitis

Drugs for Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Sucralfate Approved Phase 4 54182-58-0 0
3 Immunologic Factors Phase 4,Phase 3,Phase 2
4 Immunosuppressive Agents Phase 4,Phase 2
5 Calcineurin Inhibitors Phase 4,Phase 2
6 Antacids Phase 4
7 Anti-Ulcer Agents Phase 4
8 Gastrointestinal Agents Phase 4,Phase 2
9
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
10
Inulin Approved, Investigational, Nutraceutical Phase 3 9005-80-5 24763
11 glucocorticoids Phase 3,Phase 2
12 Bronchodilator Agents Phase 3,Phase 2
13 Hormones Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 3,Phase 2
15 Respiratory System Agents Phase 3,Phase 2
16 Hormone Antagonists Phase 3,Phase 2
17 Anti-Inflammatory Agents Phase 3,Phase 2
18 Autonomic Agents Phase 3,Phase 2
19 Anti-Asthmatic Agents Phase 3,Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
21 Cola Phase 3,Phase 2,Not Applicable
22 Acidophilus Phase 2, Phase 3
23 Vaccines Phase 3,Phase 2
24 Mesalamine Phase 3,Phase 2 89-57-6
25 Analgesics Phase 3,Phase 2
26 Analgesics, Non-Narcotic Phase 3,Phase 2
27 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
28 Antirheumatic Agents Phase 3,Phase 2
29
Bisacodyl Approved Phase 2 603-50-9
30
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
31 Orange Approved Phase 2
32
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
33
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
34
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
35
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
36
Niclosamide Approved, Investigational, Vet_approved Phase 1, Phase 2 50-65-7 4477
37
Amifostine Approved, Investigational Phase 2 20537-88-6 2141
38
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
39
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
40
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
41
Leuprolide Approved, Investigational Phase 2 53714-56-0 657181 3911
42
Camptothecin Experimental Phase 2 7689-03-4
43 Anti-Infective Agents Phase 1, Phase 2
44 Antiparasitic Agents Phase 1, Phase 2
45 Anthelmintics Phase 1, Phase 2
46 topoisomerase I inhibitors Phase 2
47 Radiation-Protective Agents Phase 2
48 Antineoplastic Agents, Phytogenic Phase 2
49 Topoisomerase Inhibitors Phase 2
50 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
2 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
3 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
4 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
5 Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer Unknown status NCT02964468 Phase 3
6 The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Completed NCT01349673 Phase 3 Budesonide Foam
7 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
8 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
9 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
10 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
11 Efficacy and Safety Study of MAX-002 Suppository Versus Placebo in Mild to Moderate Ulcerative Proctitis Terminated NCT01016262 Phase 3 MAX-002;Placebo;Canasa®
12 Clinical Trial With Mesalamine 1g Suppositories Terminated NCT01172444 Phase 3 Mesalamine;Canasa;Placebo
13 Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Terminated NCT00134628 Phase 3
14 Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer Unknown status NCT01340508 Phase 2
15 Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis Completed NCT01966783 Phase 2 Budesonide 2 mg suppository;Budesonide 4 mg suppository;Mesalazine 1 g suppository;Budesonide 2 mg suppository/Mesalazine 1 g suppository
16 Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis Completed NCT01837615 Phase 2
17 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
18 Ion Prostate Irradiation Completed NCT01641185 Phase 2
19 Brachytherapy for Recurrent Prostate Cancer Completed NCT01956058 Phase 2
20 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2 cisplatin
21 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
22 Safety, Tolerability, Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis Completed NCT01149707 Phase 2 PUR 0110 Rectal Enema 250 mg;PUR 0110 Rectal Enema 500 mg;PUR 0110 Rectal Enema 1000 mg;Placebo Enema
23 A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis Recruiting NCT03521232 Phase 1, Phase 2 Niclosamide
24 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
25 Radiation-protection Effect of Amifostine in Locally Advanced Rectal Cancer Recruiting NCT03702985 Phase 2 Capecitabine;Irinotecan;Amifostine
26 Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease Recruiting NCT03077412 Phase 2 Filgotinib;Placebo to match filgotinib
27 Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) Active, not recruiting NCT02724618 Phase 2 Curcumin;Placebo
28 Salvage Radiotherapy Combined With Hormonotherapy in Oligometastatic Pelvic Node Relapses of Prostate Cancer Active, not recruiting NCT02274779 Phase 2 ELIGARD
29 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
30 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
31 Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome Withdrawn NCT00514982 Phase 2 Mesalamine;Infliximab;Corticosteroids;6-Mercaptopurine;Tacrolimus;Adalimumab
32 Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula Recruiting NCT03643614 Phase 1
33 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933 Not Applicable
34 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492 Not Applicable
35 QUality of Life in pAtients With Mild to modeRate Active procTitis Treated by mesalaZine (Pentasa®) Completed NCT02368743 mesalazine
36 Evaluation of PillCam IBD Capsule Endoscopy System in Visualization of Lesions in the Colon Indicative of Ulcerative Colitis Disease Completed NCT02025777 Not Applicable
37 Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment Completed NCT01684514 Not Applicable
38 Quality of Life Study Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent Completed NCT02836379
39 Patients Overexposed for a Prostate Adenocarcinoma Completed NCT00773656
40 Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections Completed NCT02010294
41 Causes of Low Digestive Bleeding in Proctology Completed NCT02846285
42 Improving OutcoMes in the Pediatric to Adult Care Transition in Inflammatory Bowel Disease Completed NCT02085083 Not Applicable
43 Faecal Incontinence iNtervention Study Completed NCT02355834 Not Applicable
44 Feasibility of Online Adaptive Radiotherapy for Muscle Invasive Bladder Cancer Completed NCT01142102 Not Applicable
45 Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Recruiting NCT03259659
46 Bacterial Ano-rectitis Sexually Transmitted in a Specialized Consultation Center Recruiting NCT03625713
47 Effect of a Low Residue Diet in Comparison to the Dietetic Recommendations From the INCan in Cervical Cancer Patients Recruiting NCT03100409 Not Applicable
48 Radiation-induced Toxicity in Prostate Cancer/ Standard-Follow-Up Program Prostate Recruiting NCT03034187
49 Adjuvant Radiation for High Risk Bladder Cancer Recruiting NCT01954173 Not Applicable
50 Phenomics in Autoimmune and Inflammatory Diseases Recruiting NCT02466217

Search NIH Clinical Center for Proctitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: proctitis

Genetic Tests for Proctitis

Anatomical Context for Proctitis

MalaCards organs/tissues related to Proctitis:

41
Prostate, Colon, Cervix, Bone, Skin, Eye, Bone Marrow

Publications for Proctitis

Articles related to Proctitis:

(show top 50) (show all 714)
# Title Authors Year
1
Proctitis and perirectal abscesses: is there anything else to think about? ( 29722270 )
2018
2
Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis. ( 29702300 )
2018
3
A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm. ( 29399616 )
2018
4
Effects of mesalazine enemas on lymphoid follicular proctitis. ( 29931988 )
2018
5
Acetarsol Suppositories: Effective Treatment for Refractory Proctitis in a Cohort of Patients with Inflammatory Bowel Disease. ( 29457211 )
2018
6
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats. ( 29768539 )
2018
7
Mini-Fecal Microbiota Transplantation for Treatment of Clostridium difficile Proctitis Following Total Colectomy. ( 29020255 )
2018
8
Long extensive radiation proctitis treated with rectal band ligation (with video). ( 29884558 )
2018
9
Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository. ( 29393142 )
2018
10
Rectoprostate Fistula After Endoscopic Treatment of RadiationA Proctitis. ( 29678438 )
2018
11
Management of Radiation Proctitis. ( 29948565 )
2018
12
Proctitis Caused by <i>Mycobacterium avium-intracellulare</i> in an HIV-Infected Patient. ( 29738438 )
2018
13
Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo. ( 29080145 )
2018
14
Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model. ( 29629351 )
2018
15
Multi Matrix System Mesalazine Plus Rectal Mesalazine in the Treatment of Mild to Moderately Active Ulcerative Proctitis. ( 29339645 )
2018
16
Infectious proctitis: a necessary differential diagnosis in ulcerative colitis. ( 30402768 )
2018
17
Lymphogranuloma Venereum Proctitis. ( 30081010 )
2018
18
Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis. ( 30012529 )
2018
19
Phlegmonous Proctitis: A Rare Entity of the Presentation of Proctitis. ( 30022913 )
2018
20
International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study. ( 30157890 )
2018
21
Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis. ( 30186474 )
2018
22
Comparison of relative and absolute rectal dose-volume parameters and clinical correlation with acute and late radiation proctitis in prostate cancer patients. ( 30191285 )
2018
23
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Chronic Radiation Proctitis. ( 30192320 )
2018
24
The role of endoscopic evaluation for radiation proctitis in patients receiving intermediate-dose postoperative radiotherapy for rectal cancer. ( 30239826 )
2018
25
Linear IgA bullous dermatosis associated with ulcerative proctitis: treatment challenge. ( 30261573 )
2018
26
Early Onset Allergic Proctitis in a Preterm Neonate-A Case Report and Review of the Literature. ( 30286677 )
2018
27
Primary syphilitic proctitis : case report and literature review. ( 30350534 )
2018
28
Endoscopic progression of ulcerative proctitis to proximal disease. Can we identify predictors of progression? ( 30351984 )
2018
29
Acetarsol in the management of mesalazine-refractory ulcerative proctitis: a tertiary-level care experience. ( 30499784 )
2018
30
A Case of Asymptomatic Syphilitic Proctitis. ( 30516724 )
2018
31
Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in the Treatment for Left-Sided Ulcerative Colitis and Ulcerative Proctitis. ( 29207381 )
2017
32
Two Cases of Neisseria meningitidis Proctitis in HIV-Positive Men Who Have Sex with Men. ( 28221124 )
2017
33
Chlamydia trachomatis proctitis masquerading as carcinoma rectum: First case report from India. ( 28631649 )
2017
34
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
35
Expression of Vascular Endothelial Growth Factor (VEGF) and its Correlation with Clinical Symptoms and Endoscopic Findings in Patients with Chronic Radiation Proctitis. ( 28963746 )
2017
36
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
37
Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis. ( 28286194 )
2017
38
Therapeutic requirements in active ulcerative proctitis: A single-centre study. ( 28666605 )
2017
39
Efficacy of topical 5-aminosalicylate monotherapy in patients with ulcerative proctitis with skip inflammation. ( 29205498 )
2017
40
Are patients in the IBD clinic at risk of proctitis secondary to sexually transmitted infections? ( 29067152 )
2017
41
Proctitis And Anusitis ( 28613642 )
2017
42
The role of confocal laser endomicroscopy in assessing mucosal healing in patients with ulcerative proctitis. ( 29186737 )
2017
43
Ischemic Proctitis Presenting as Rectal Pain and Bloody Diarrhea with No Apparent Cause. ( 28761891 )
2017
44
Co-infection by lymphogranuloma venereum and Haemophilus parainfluenzae during an episode of proctitis. ( 28196678 )
2017
45
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
46
Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. ( 28232224 )
2017
47
Clinical and microbiological aspects of the use of Lactobacillus rhamnosus PL1 strains in proctological patients with symptoms of chronic proctitis. ( 28703111 )
2017
48
Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis. ( 28922252 )
2017
49
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
50
Herpes Simplex Proctitis Mimicking Inflammatory Bowel Disease in a Teenaged Male. ( 28473937 )
2017

Variations for Proctitis

Expression for Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for Proctitis

GO Terms for Proctitis

Cellular components related to Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CRP EPX FGF2 KLK3 LTF MPO
2 secretory granule GO:0030141 9.33 KLK3 LTF MPO
3 extracellular region GO:0005576 9.28 CRP EPX FGF2 KDR KLK3 LTF

Biological processes related to Proctitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.71 EPX LTF MPO RNASE3
2 extracellular matrix organization GO:0030198 9.65 FGF2 KDR TNF
3 defense response GO:0006952 9.5 EPX MPO TNF
4 antibacterial humoral response GO:0019731 9.49 LTF RNASE3
5 hydrogen peroxide catabolic process GO:0042744 9.46 EPX MPO
6 innate immune response in mucosa GO:0002227 9.43 LTF RNASE3
7 cell migration involved in sprouting angiogenesis GO:0002042 9.37 FGF2 KDR
8 defense response to Gram-positive bacterium GO:0050830 9.33 CRP RNASE3 TNF
9 negative regulation of growth of symbiont in host GO:0044130 9.26 MPO TNF
10 defense response to bacterium GO:0042742 9.02 EPX LTF MPO RNASE3 TNF
11 negative regulation of lipid storage GO:0010888 8.96 CRP TNF

Molecular functions related to Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.26 LTF RNASE3
2 peroxidase activity GO:0004601 9.16 EPX MPO
3 heparin binding GO:0008201 9.13 FGF2 LTF MPO
4 heme binding GO:0020037 8.8 CYP3A5 EPX MPO

Sources for Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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