Aliases & Classifications for Proctitis

MalaCards integrated aliases for Proctitis:

Name: Proctitis 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3127
ICD10 33 K62.89
MeSH 44 D011349
NCIt 50 C38011
UMLS 73 C0033246

Summaries for Proctitis

Disease Ontology : 12 A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding.

MalaCards based summary : Proctitis is related to radiation proctitis and ulcerative colitis, and has symptoms including rectal tenesmus An important gene associated with Proctitis is EPX (Eosinophil Peroxidase), and among its related pathways/superpathways are Folate Metabolism and Proteoglycans in cancer. The drugs Tacrolimus and Sucralfate have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and neutrophil.

Wikipedia : 76 Proctitis is an inflammation of the anus and the lining of the rectum, affecting only the last... more...

Related Diseases for Proctitis

Diseases related to Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 radiation proctitis 31.9 ENTPD1 FGF2 KDR LTF TNF
2 ulcerative colitis 31.0 CRP MPO TNF
3 collagenous colitis 30.1 EPX MPO RNASE3
4 gastroenteritis 30.0 CRP RNASE3 TNF
5 pneumonia 29.8 CRP MPO TNF
6 inflammatory bowel disease 29.2 CRP EPX LTF MPO TNF
7 ulcerative proctitis 12.5
8 eosinophilic granuloma 10.8 EPX RNASE3
9 inflammatory bowel disease 4 10.8 EPX RNASE3
10 eosinophil peroxidase deficiency 10.8 EPX MPO
11 conjunctival nevus 10.8 EPX RNASE3
12 eosinophilic gastroenteritis 10.7 EPX RNASE3
13 autoimmune inner ear disease 10.7 MPO TNF
14 urinary schistosomiasis 10.7 EPX RNASE3
15 maxillary sinusitis 10.7 MPO RNASE3
16 chronic rhinitis 10.7 EPX MPO
17 microscopic polyangiitis 10.7 MPO TNF
18 anca-associated vasculitis 10.7 MPO TNF
19 mononeuritis multiplex 10.6 CRP MPO
20 melancholia 10.6 CRP TNF
21 pollen allergy 10.6 EPX RNASE3
22 aortitis 10.6 CRP MPO
23 mediastinitis 10.6 CRP MPO
24 relapsing fever 10.6 CRP TNF
25 henoch-schoenlein purpura 10.6 MPO RNASE3
26 central nervous system vasculitis 10.6 CRP TNF
27 giant papillary conjunctivitis 10.6 LTF RNASE3
28 rapidly progressive glomerulonephritis 10.6 CRP MPO
29 hypersensitivity vasculitis 10.6 CRP MPO
30 louse-borne relapsing fever 10.6 CRP TNF
31 tuberculous peritonitis 10.5 CRP TNF
32 pulmonary aspergilloma 10.5 CRP MPO
33 ischemic heart disease 10.5 CRP TNF
34 haemophilus influenzae 10.5 LTF TNF
35 hypersensitivity reaction type iii disease 10.5 CRP MPO
36 chronic maxillary sinusitis 10.5 MPO RNASE3
37 bursitis 10.5 CRP KDR
38 streptococcal meningitis 10.5 CRP TNF
39 rheumatoid vasculitis 10.5 LTF TNF
40 colitis 10.5
41 laryngitis 10.5 FGF2 TNF
42 bronchial disease 10.4 EPX RNASE3 TNF
43 leukostasis 10.4 KDR MPO
44 scrub typhus 10.4 CRP TNF
45 vernal conjunctivitis 10.4 EPX MPO RNASE3
46 rectal disease 10.4 KLK3 TNF
47 systolic heart failure 10.4 CRP TNF
48 chronic ulcer of skin 10.4 CRP FGF2
49 decubitus ulcer 10.4 CRP FGF2
50 churg-strauss syndrome 10.4 MPO RNASE3 TNF

Graphical network of the top 20 diseases related to Proctitis:



Diseases related to Proctitis

Symptoms & Phenotypes for Proctitis

UMLS symptoms related to Proctitis:


rectal tenesmus

Drugs & Therapeutics for Proctitis

Drugs for Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
2
Sucralfate Approved Phase 4 54182-58-0 0
3 Calcineurin Inhibitors Phase 4,Phase 2
4 Immunosuppressive Agents Phase 4,Phase 2
5 Antacids Phase 4
6 Anti-Ulcer Agents Phase 4
7 Gastrointestinal Agents Phase 4,Phase 2
8
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
9
Inulin Approved, Investigational, Nutraceutical Phase 3 9005-80-5 24763
10 Anti-Asthmatic Agents Phase 3,Phase 2
11 Anti-Inflammatory Agents Phase 3,Phase 2
12 Autonomic Agents Phase 3,Phase 2
13 Bronchodilator Agents Phase 3,Phase 2
14 glucocorticoids Phase 3,Phase 2
15 Hormone Antagonists Phase 3,Phase 2
16 Hormones Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Respiratory System Agents Phase 3,Phase 2
20 Vaccines Phase 3,Phase 2
21 Analgesics Phase 3,Phase 2
22 Analgesics, Non-Narcotic Phase 3,Phase 2
23 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
24 Antirheumatic Agents Phase 3,Phase 2
25 Mesalamine Phase 3,Phase 2 89-57-6
26 Cola Nutraceutical Phase 3,Phase 2,Not Applicable
27 Acidophilus Nutraceutical Phase 2, Phase 3
28
Bisacodyl Approved Phase 2 603-50-9
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
30
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
31
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
32
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
33
Curcumin Approved, Investigational Phase 2 458-37-7 969516
34
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
35
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
36 Orange Approved, Nutraceutical Phase 2
37 Androgen Antagonists Phase 2
38 Androgens Phase 2
39 Antineoplastic Agents, Hormonal Phase 2
40 Complement System Proteins Phase 2
41 Fertility Agents Phase 2
42
Epinephrine Approved, Vet_approved 51-43-4 5816
43
Racepinephrine Approved 329-65-7 838
44 Epinephryl borate
45 Anesthetics Not Applicable

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis Completed NCT01418131 Phase 4 Rectal tacrolimus;Placebo
2 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
3 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
4 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
5 The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis Completed NCT01349673 Phase 3 Budesonide Foam
6 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
7 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008423 Phase 3 Budesonide;Placebo
8 Efficacy and Safety of Budesonide Foam for Patients With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis Completed NCT01008410 Phase 3 Budesonide;Placebo
9 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
10 Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer Recruiting NCT02964468 Phase 3
11 Efficacy and Safety Study of MAX-002 Suppository Versus Placebo in Mild to Moderate Ulcerative Proctitis Terminated NCT01016262 Phase 3 MAX-002;Placebo;Canasa®
12 Clinical Trial With Mesalamine 1g Suppositories Terminated NCT01172444 Phase 3 Mesalamine;Canasa;Placebo
13 Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries Terminated NCT00134628 Phase 3
14 Preoperative Concurrent Chemotherapy and Intensity Modulated Radiotherapy (IMRT) in Locally Advanced Rectal Cancer Unknown status NCT01340508 Phase 2
15 Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis Completed NCT01966783 Phase 2 Budesonide 2 mg suppository;Budesonide 4 mg suppository;Mesalazine 1 g suppository;Budesonide 2 mg suppository/Mesalazine 1 g suppository
16 Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis Completed NCT01837615 Phase 2
17 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
18 Ion Prostate Irradiation Completed NCT01641185 Phase 2
19 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2 cisplatin
20 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
21 Safety, Tolerability, Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis Completed NCT01149707 Phase 2 PUR 0110 Rectal Enema 250 mg;PUR 0110 Rectal Enema 500 mg;PUR 0110 Rectal Enema 1000 mg;Placebo Enema
22 A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis Recruiting NCT03521232 Phase 1, Phase 2 Niclosamide
23 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
24 Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease Recruiting NCT03077412 Phase 2 Filgotinib;Placebo to match filgotinib
25 Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT) Active, not recruiting NCT02724618 Phase 2 Curcumin;Placebo
26 Brachytherapy for Recurrent Prostate Cancer Active, not recruiting NCT01956058 Phase 2
27 Salvage Radiotherapy Combined With Hormonotherapy in Oligometastatic Pelvic Node Relapses of Prostate Cancer Active, not recruiting NCT02274779 Phase 2 ELIGARD
28 Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy Not yet recruiting NCT02814864 Phase 2
29 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
30 Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome Withdrawn NCT00514982 Phase 2 Mesalamine;Infliximab;Corticosteroids;6-Mercaptopurine;Tacrolimus;Adalimumab
31 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933 Not Applicable
32 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492 Not Applicable
33 QUality of Life in pAtients With Mild to modeRate Active procTitis Treated by mesalaZine (Pentasa®) Completed NCT02368743 mesalazine
34 Evaluation of PillCam IBD Capsule Endoscopy System in Visualization of Lesions in the Colon Indicative of Ulcerative Colitis Disease Completed NCT02025777 Not Applicable
35 Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment Completed NCT01684514 Not Applicable
36 Quality of Life Study Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent Completed NCT02836379
37 Patients Overexposed for a Prostate Adenocarcinoma Completed NCT00773656
38 Causes of Low Digestive Bleeding in Proctology Completed NCT02846285
39 Improving OutcoMes in the Pediatric to Adult Care Transition in Inflammatory Bowel Disease Completed NCT02085083 Not Applicable
40 Feasibility of Online Adaptive Radiotherapy for Muscle Invasive Bladder Cancer Completed NCT01142102 Not Applicable
41 Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis Recruiting NCT03259659
42 Effect of a Low Residue Diet in Comparison to the Dietetic Recommendations From the INCan in Cervical Cancer Patients Recruiting NCT03100409 Not Applicable
43 Radiation-induced Toxicity in Prostate Cancer/ Standard-Follow-Up Program Prostate Recruiting NCT03034187
44 Adjuvant Radiation for High Risk Bladder Cancer Recruiting NCT01954173 Not Applicable
45 Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections Recruiting NCT02010294
46 Faecal Incontinence iNtervention Study Recruiting NCT02355834 Not Applicable
47 Phenomics in Autoimmune and Inflammatory Diseases Recruiting NCT02466217
48 Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial) Active, not recruiting NCT01627288 Not Applicable
49 Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study Not yet recruiting NCT03397901 Not Applicable
50 Hyperbaric Oxygenation Treatment and Quality of Life Not yet recruiting NCT03570229

Search NIH Clinical Center for Proctitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: proctitis

Genetic Tests for Proctitis

Anatomical Context for Proctitis

MalaCards organs/tissues related to Proctitis:

41
Prostate, Colon, Neutrophil, Endothelial, Cervix, Skin, Bone

Publications for Proctitis

Articles related to Proctitis:

(show top 50) (show all 628)
# Title Authors Year
1
Proctitis and perirectal abscesses: is there anything else to think about? ( 29722270 )
2018
2
Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis. ( 29702300 )
2018
3
A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm. ( 29399616 )
2018
4
Effects of mesalazine enemas on lymphoid follicular proctitis. ( 29931988 )
2018
5
Acetarsol Suppositories: Effective Treatment for Refractory Proctitis in a Cohort of Patients with Inflammatory Bowel Disease. ( 29457211 )
2018
6
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats. ( 29768539 )
2018
7
Mini-Fecal Microbiota Transplantation for Treatment of Clostridium difficile Proctitis Following Total Colectomy. ( 29020255 )
2018
8
Long extensive radiation proctitis treated with rectal band ligation (with video). ( 29884558 )
2018
9
Optimized Management of Ulcerative Proctitis: When and How to Use Mesalazine Suppository. ( 29393142 )
2018
10
Rectoprostate Fistula After Endoscopic Treatment of RadiationA Proctitis. ( 29678438 )
2018
11
Management of Radiation Proctitis. ( 29948565 )
2018
12
Proctitis Caused by <i>Mycobacterium avium-intracellulare</i> in an HIV-Infected Patient. ( 29738438 )
2018
13
Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo. ( 29080145 )
2018
14
Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model. ( 29629351 )
2018
15
Multi Matrix System Mesalazine Plus Rectal Mesalazine in the Treatment of Mild to Moderately Active Ulcerative Proctitis. ( 29339645 )
2018
16
Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in the Treatment for Left-Sided Ulcerative Colitis and Ulcerative Proctitis. ( 29207381 )
2017
17
Two Cases of Neisseria meningitidis Proctitis in HIV-Positive Men Who Have Sex with Men. ( 28221124 )
2017
18
Chlamydia trachomatis proctitis masquerading as carcinoma rectum: First case report from India. ( 28631649 )
2017
19
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
20
Expression of Vascular Endothelial Growth Factor (VEGF) and its Correlation with Clinical Symptoms and Endoscopic Findings in Patients with Chronic Radiation Proctitis. ( 28963746 )
2017
21
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
22
Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis. ( 28286194 )
2017
23
Therapeutic requirements in active ulcerative proctitis: A single-centre study. ( 28666605 )
2017
24
Efficacy of topical 5-aminosalicylate monotherapy in patients with ulcerative proctitis with skip inflammation. ( 29205498 )
2017
25
Are patients in the IBD clinic at risk of proctitis secondary to sexually transmitted infections? ( 29067152 )
2017
26
Proctitis And Anusitis ( 28613642 )
2017
27
The role of confocal laser endomicroscopy in assessing mucosal healing in patients with ulcerative proctitis. ( 29186737 )
2017
28
Ischemic Proctitis Presenting as Rectal Pain and Bloody Diarrhea with No Apparent Cause. ( 28761891 )
2017
29
Co-infection by lymphogranuloma venereum and Haemophilus parainfluenzae during an episode of proctitis. ( 28196678 )
2017
30
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
31
Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. ( 28232224 )
2017
32
Clinical and microbiological aspects of the use of Lactobacillus rhamnosus PL1 strains in proctological patients with symptoms of chronic proctitis. ( 28703111 )
2017
33
Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis. ( 28922252 )
2017
34
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
35
Herpes Simplex Proctitis Mimicking Inflammatory Bowel Disease in a Teenaged Male. ( 28473937 )
2017
36
Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma. ( 28707144 )
2017
37
Lymphogranuloma Venereum Proctitis. ( 28365488 )
2017
38
Lymphoid follicular proctitis resembling rectal carcinoid tumor, confirmed by endoscopic resection. ( 28415161 )
2017
39
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
40
Editorial: does disease extension lead to disease progression in proctitis? ( 28621077 )
2017
41
Proctitis 1 Week after Stereotactic Body Radiation Therapy for Prostate Cancer: Implications for Clinical Trial Design. ( 27489794 )
2016
42
Did L Strains Responsible for Lymphogranuloma Venereum Proctitis Spread Among People With Genital Chlamydia trachomatis Infection in France in 2013? ( 27200521 )
2016
43
Azathioprine for refractory ulcerative proctitis: A retrospective multicenter study. ( 28089625 )
2016
44
Oral 5-Aminosalicylate, Mesalamine Suppository, and Mesalamine Enema as Initial Therapy for Ulcerative Proctitis in Clinical Practice with Quality of Care Implications. ( 27446860 )
2016
45
The contribution of Mycoplasma genitalium to the aetiology of sexually acquired infectious proctitis in men who have sex with men. ( 26686807 )
2016
46
Baseline Oral 5-ASA Use and Efficacy and Safety of Budesonide Foam in Patients with Ulcerative Proctitis and Ulcerative Proctosigmoiditis: Analysis of 2 Phase 3 Studies. ( 27416045 )
2016
47
Syphilitic proctitis. ( 27365889 )
2016
48
Severe Proctitis Caused by Chlamydia trachomatis Serovars D. ( 27803429 )
2016
49
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
50
Exploring the Management of Radiation Proctitis in Current Clinical Practice. ( 27504391 )
2016

Variations for Proctitis

Expression for Proctitis

Search GEO for disease gene expression data for Proctitis.

Pathways for Proctitis

Pathways related to Proctitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 CRP MPO TNF
2 11.8 FGF2 KDR TNF
3 10.64 FGF2 KDR
4 10.43 CRP TNF
5 10.16 MPO TNF
6 9.8 CYP3A5 MPO

GO Terms for Proctitis

Cellular components related to Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 CRP ENTPD1 EPX KLK3 LTF MPO
2 extracellular space GO:0005615 9.56 CRP EPX FGF2 KLK3 LTF MPO
3 secretory granule GO:0030141 9.33 KLK3 LTF MPO
4 extracellular region GO:0005576 9.28 CRP EPX FGF2 KDR KLK3 LTF

Biological processes related to Proctitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.76 EPX LTF MPO RNASE3
2 extracellular matrix organization GO:0030198 9.67 FGF2 KDR TNF
3 defense response GO:0006952 9.58 EPX MPO TNF
4 antibacterial humoral response GO:0019731 9.52 LTF RNASE3
5 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.51 FGF2 KDR
6 innate immune response in mucosa GO:0002227 9.48 LTF RNASE3
7 hydrogen peroxide catabolic process GO:0042744 9.43 EPX MPO
8 defense response to Gram-positive bacterium GO:0050830 9.43 CRP RNASE3 TNF
9 cell migration involved in sprouting angiogenesis GO:0002042 9.37 FGF2 KDR
10 negative regulation of growth of symbiont in host GO:0044130 9.32 MPO TNF
11 negative regulation of lipid storage GO:0010888 9.16 CRP TNF
12 defense response to bacterium GO:0042742 9.02 EPX LTF MPO RNASE3 TNF
13 negative regulation by host of viral process GO:0044793 8.96 CRP LTF

Molecular functions related to Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.26 LTF RNASE3
2 peroxidase activity GO:0004601 9.16 EPX MPO
3 heparin binding GO:0008201 9.13 FGF2 LTF MPO
4 heme binding GO:0020037 8.8 CYP3A5 EPX MPO

Sources for Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....