MCID: PRG003
MIFTS: 29

Progesterone-Receptor Negative Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Progesterone-Receptor Negative Breast Cancer

MalaCards integrated aliases for Progesterone-Receptor Negative Breast Cancer:

Name: Progesterone-Receptor Negative Breast Cancer 12 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0060078

Summaries for Progesterone-Receptor Negative Breast Cancer

Disease Ontology : 12 A breast cancer that is characterized by the absence of progesterone receptors.

MalaCards based summary : Progesterone-Receptor Negative Breast Cancer is related to breast cancer and scirrhous adenocarcinoma. An important gene associated with Progesterone-Receptor Negative Breast Cancer is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include breast, lymph node and prostate, and related phenotype is neoplasm.

Related Diseases for Progesterone-Receptor Negative Breast Cancer

Diseases in the Progesterone-Receptor Positive Breast Cancer family:

Progesterone-Receptor Negative Breast Cancer

Diseases related to Progesterone-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 breast cancer 10.5
2 scirrhous adenocarcinoma 10.3 PGR ERBB2
3 lipid-rich breast carcinoma 10.3 PGR ERBB2
4 apocrine adenosis of breast 10.3 PGR ERBB2
5 luminal breast carcinoma b 10.3 PGR ERBB2
6 breast mucinous carcinoma 10.3 PGR ERBB2
7 gastric diffuse adenocarcinoma 10.3 PGR ERBB2
8 linitis plastica 10.3 PGR ERBB2
9 breast sarcoma 10.3 PGR ERBB2
10 triple-receptor negative breast cancer 10.3 PGR ERBB2
11 breast papillomatosis 10.3 PGR ERBB2
12 submandibular gland cancer 10.2 ERBB2 EGFR
13 bartholin's gland adenoma 10.2 PGR ESR1
14 bartholin's gland adenoid cystic carcinoma 10.2 PGR ESR1
15 uterine corpus adenosarcoma 10.2 PGR ESR1
16 bartholin's gland benign neoplasm 10.2 PGR ESR1
17 chronic tympanitis 10.2 PGR ESR1
18 paronychia 10.2 ERBB2 EGFR
19 vestibular gland benign neoplasm 10.2 PGR ESR1
20 granulomatous endometritis 10.2 PGR ESR1
21 vulvar syringoma 10.2 PGR ESR1
22 lung leiomyoma 10.2 PGR ESR1
23 adult type testicular granulosa cell tumor 10.2 PGR ESR1
24 cervical clear cell adenocarcinoma 10.2 PGR ESR1
25 biliary tract cancer 10.2 ERBB2 EGFR
26 ovarian seromucinous carcinoma 10.2 PGR ESR1
27 ethmoid sinus adenocarcinoma 10.2 ERBB2 EGFR
28 liver leiomyoma 10.2 PGR ESR1
29 breast squamous cell carcinoma 10.2 ESR1 ERBB2
30 intravenous leiomyomatosis 10.2 PGR ESR1
31 intracranial meningioma 10.2 PGR ESR1
32 vulvar leiomyoma 10.2 PGR ESR1
33 bizarre leiomyoma 10.2 PGR ESR1
34 breast adenoma 10.2 PGR ESR1
35 prostate stromal sarcoma 10.2 PGR ESR1
36 lung non-squamous non-small cell carcinoma 10.2 ERBB2 EGFR
37 benign breast adenomyoepithelioma 10.2 ESR1 EGFR
38 urethral benign neoplasm 10.2 PGR ESR1
39 cervical adenosarcoma 10.2 PGR ESR1
40 gender identity disorder 10.2 PGR ESR1
41 gastroesophageal junction adenocarcinoma 10.2 ERBB2 EGFR
42 progesterone resistance 10.2 PGR ESR1
43 vulvar disease 10.2 ERBB2 EGFR
44 biphasic synovial sarcoma 10.2 PGR ESR1
45 vaginal cancer 10.1 PGR ESR1
46 primary peritoneal carcinoma 10.1 PGR ERBB2 EGFR
47 juvenile nasopharyngeal angiofibroma 10.1 PGR ESR1
48 trigonitis 10.1 PGR ESR1
49 vaginal discharge 10.1 PGR ESR1
50 periampullary adenocarcinoma 10.1 ERBB2 EGFR

Graphical network of the top 20 diseases related to Progesterone-Receptor Negative Breast Cancer:



Diseases related to Progesterone-Receptor Negative Breast Cancer

Symptoms & Phenotypes for Progesterone-Receptor Negative Breast Cancer

MGI Mouse Phenotypes related to Progesterone-Receptor Negative Breast Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 EGFR ERBB2 ESR1 PGR TLR4

Drugs & Therapeutics for Progesterone-Receptor Negative Breast Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II, Randomised, Double-Blind, Placebocontrolled Study To Investigate The Effects Of ZD1839 (IRESSA™) On Cell Proliferation In Oestrogen And Progesterone Receptor Negative Breast Cancer Prior To Surgery Withdrawn NCT00252811 Phase 2 Gefitinib

Search NIH Clinical Center for Progesterone-Receptor Negative Breast Cancer

Genetic Tests for Progesterone-Receptor Negative Breast Cancer

Anatomical Context for Progesterone-Receptor Negative Breast Cancer

MalaCards organs/tissues related to Progesterone-Receptor Negative Breast Cancer:

40
Breast, Lymph Node, Prostate

Publications for Progesterone-Receptor Negative Breast Cancer

Articles related to Progesterone-Receptor Negative Breast Cancer:

(show all 37)
# Title Authors PMID Year
1
A meta-analysis of Watson for Oncology in clinical application. 61
33707577 2021
2
Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study. 61
32878860 2020
3
Estrogen Receptor Positive and Progesterone Receptor Negative Breast Cancer: the Role of Hormone Therapy. 61
32519274 2020
4
Low RAB6C expression is a predictor of tamoxifen benefit in estrogen receptor-positive/progesterone receptor-negative breast cancer. 61
32257197 2020
5
Increased androgen receptor expression in estrogen receptor-positive/progesterone receptor-negative breast cancer. 61
31950383 2020
6
RAB6C is an independent prognostic factor of estrogen receptor-positive/progesterone receptor-negative breast cancer. 61
31897114 2020
7
Final Analysis of the Prevention of Early Menopause Study (POEMS)/SWOG Intergroup S0230. 61
30371800 2019
8
Geographic Distribution and Survival Outcomes for Rural Patients With Cancer Treated in Clinical Trials. 61
30646114 2018
9
Identification of a novel human estrogen receptor-α splice variant able to enhance malignant biological behaviors of breast cancer cells. 61
29552176 2018
10
[Research progress on significance of androgen receptor and epidermal growth factor receptor expression in estrogen receptor-negative and progesterone receptor-negative breast cancer]. 61
29534371 2018
11
Outcome after neoadjuvant chemotherapy in estrogen receptor-positive and progesterone receptor-negative breast cancer patients: a pooled analysis of individual patient data from ten prospectively randomized controlled neoadjuvant trials. 61
28875243 2018
12
SF3B1 mutation is a poor prognostic indicator in luminal B and progesterone receptor-negative breast cancer patients. 61
29383138 2017
13
Mediation of Racial and Ethnic Disparities in Estrogen/Progesterone Receptor-Negative Breast Cancer by Socioeconomic Position and Reproductive Factors. 61
27076668 2016
14
Elevated Resistin Gene Expression in African American Estrogen and Progesterone Receptor Negative Breast Cancer. 61
27314854 2016
15
Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer. 61
26392082 2015
16
A model of spontaneous mouse mammary tumor for human estrogen receptor- and progesterone receptor-negative breast cancer. 61
25230850 2014
17
Reproductive risk factors and oestrogen/progesterone receptor-negative breast cancer in the Breast Cancer Family Registry. 61
24548865 2014
18
A clinical trial of lovastatin for modification of biomarkers associated with breast cancer risk. 61
24166281 2013
19
Physical activity and risk of breast cancer: a meta-analysis of prospective studies. 61
23274845 2013
20
Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. 61
21791674 2011
21
Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health Study. 61
20937636 2010
22
Oral contraceptive use and estrogen/progesterone receptor-negative breast cancer among African American women. 61
20647407 2010
23
Meat mutagens and breast cancer in postmenopausal women--a cohort analysis. 61
20447922 2010
24
Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. 61
19898421 2010
25
Statins May Reduce Breast Cancer Risk, Particularly Hormone Receptor-Negative Disease. 61
22540021 2009
26
Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea. 61
19190159 2009
27
Caffeine consumption and the risk of breast cancer in a large prospective cohort of women. 61
18852405 2008
28
A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk. 61
17975727 2008
29
A prospective study of multivitamin supplement use and risk of breast cancer. 61
18344515 2008
30
A significant correlation between nuclear CXCR4 expression and axillary lymph node metastasis in hormonal receptor negative breast cancer. 61
17763975 2008
31
Randomized trial of high-dose chemotherapy with autologous peripheral-blood stem-cell support compared with standard-dose chemotherapy in women with metastatic breast cancer: NCIC MA.16. 61
18025439 2008
32
Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance. 61
16145046 2005
33
Association of cyclin D1 genotype with breast cancer risk and survival. 61
15668481 2005
34
Increased dihydropyrimidine dehydrogenase activity in breast cancer. 61
12619061 2003
35
Preferential topography of proteins regulating vascularization and apoptosis in a MX1 xenotransplant after treatment with hypoxia, hyperthermia, ifosfamide, and irradiation. 61
12151958 2002
36
Differences in breast cancer hormone receptor status and histology by race and ethnicity among women 50 years of age and older. 61
12101106 2002
37
Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line. 61
3702420 1986

Variations for Progesterone-Receptor Negative Breast Cancer

Expression for Progesterone-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Progesterone-Receptor Negative Breast Cancer.

Pathways for Progesterone-Receptor Negative Breast Cancer

Pathways related to Progesterone-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 PGR ESR1 ERBB2 EGFR
2
Show member pathways
11.96 ESR1 ERBB2 EGFR
3
Show member pathways
11.59 TLR4 ERBB2 EGFR
4 11.57 TLR4 ESR1 ERBB2 EGFR
5 11.47 TLR4 ERBB2 EGFR
6
Show member pathways
11.3 ESR1 ERBB2 EGFR
7
Show member pathways
10.96 PGR ESR1 ERBB2 EGFR
8 10.92 ERBB2 EGFR
9 10.88 ERBB2 EGFR

GO Terms for Progesterone-Receptor Negative Breast Cancer

Cellular components related to Progesterone-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.65 TLR4 SPATS2L SPATS2 RAB6C PGR NXF2B
2 receptor complex GO:0043235 9.33 TLR4 ERBB2 EGFR
3 nuclear RNA export factor complex GO:0042272 8.62 NXF2B NXF2

Biological processes related to Progesterone-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.95 TLR4 RETN PGR ESR1 ERBB2 EGFR
2 positive regulation of protein kinase B signaling GO:0051897 9.54 ESR1 ERBB2 EGFR
3 regulation of cell motility GO:2000145 9.46 ERBB2 EGFR
4 regulation of ERK1 and ERK2 cascade GO:0070372 9.43 ERBB2 EGFR
5 ERBB2 signaling pathway GO:0038128 9.4 ERBB2 EGFR
6 steroid hormone mediated signaling pathway GO:0043401 9.32 PGR ESR1
7 poly(A)+ mRNA export from nucleus GO:0016973 9.26 NXF2B NXF2
8 RNA transport GO:0050658 9.16 NXF2B NXF2
9 intracellular steroid hormone receptor signaling pathway GO:0030518 8.96 PGR ESR1
10 negative regulation of ERBB signaling pathway GO:1901185 8.62 ERBB2 EGFR

Molecular functions related to Progesterone-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.26 PGR ESR1
2 steroid hormone receptor activity GO:0003707 9.16 PGR ESR1
3 ATPase binding GO:0051117 9.13 PGR ESR1 EGFR
4 nitric-oxide synthase regulator activity GO:0030235 8.62 ESR1 EGFR

Sources for Progesterone-Receptor Negative Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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