Aliases & Classifications for Progesterone Resistance

MalaCards integrated aliases for Progesterone Resistance:

Name: Progesterone Resistance 58 30 13 56 41 74
Pseudocorpus Luteum Insufficiency 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
progesterone resistance:
Inheritance autosomal recessive inheritance


External Ids:

OMIM 58 264080
MedGen 43 C1849699
SNOMED-CT via HPO 70 258211005 6738008
UMLS 74 C1849699

Summaries for Progesterone Resistance

OMIM : 58 Progesterone prepares the endometrium for blastocyst implantation and allows maintenance of pregnancy. The major sources of progesterone are the corpus luteum during the second half of the menstrual cycle and at the beginning of pregnancy, and the placenta. The main hormones responsible for stimulation of progesterone secretion are luteinizing hormone (LH) for the corpus luteum of the menstrual cycle and chorionic gonadotropin for the corpus luteum of pregnancy. Complete end-organ resistance to progesterone would be incompatible with reproductive competence in females. Males would not be expected to be affected since progesterone has no known function in men. Failure of the uterus to respond to progesterone would lead to the development of a 'constantly proliferative' endometrium incompatible with blastocyst implantation. Partial resistance to progesterone, on the other hand, would be expected to be associated with various degrees of incomplete maturation of the endometrium, perhaps expressed clinically as infertility or early abortions. The syndrome would present with the clinical and histologic picture of a luteal phase defect in which the life span of the corpus luteum and the plasma progesterone concentrations would be normal or elevated. (264080)

MalaCards based summary : Progesterone Resistance, also known as pseudocorpus luteum insufficiency, is related to endometrial cancer and endometriosis. An important gene associated with Progesterone Resistance is PGR (Progesterone Receptor), and among its related pathways/superpathways are Circadian entrainment and Gastric cancer. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include uterus, placenta and breast, and related phenotypes are abnormality of metabolism/homeostasis and female infertility

Related Diseases for Progesterone Resistance

Diseases related to Progesterone Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 endometrial cancer 29.8 ESR1 ESR2 KRAS PGR
2 endometriosis 29.7 ESR1 ESR2 MIR29C PGR
3 vestibular gland benign neoplasm 10.3 ESR1 PGR
4 bartholin's gland adenoma 10.3 ESR1 PGR
5 vulvar syringoma 10.3 ESR1 PGR
6 lung leiomyoma 10.3 ESR1 PGR
7 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
8 vulvar benign neoplasm 10.3 ESR1 PGR
9 trigonitis 10.3 ESR1 PGR
10 vulvar leiomyoma 10.3 ESR1 PGR
11 predominantly cortical thymoma 10.3 ESR1 PGR
12 breast medullary carcinoma 10.3 ESR1 PGR
13 breast scirrhous carcinoma 10.3 ESR1 PGR
14 bartholin's gland benign neoplasm 10.2 ESR1 PGR
15 oncocytic breast carcinoma 10.2 ESR1 PGR
16 endometrial squamous cell carcinoma 10.2 ESR1 PGR
17 cribriform carcinoma 10.2 ESR1 PGR
18 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
19 adenoid basal cell carcinoma 10.2 ESR1 PGR
20 apocrine adenocarcinoma 10.2 ESR1 PGR
21 peritoneal benign neoplasm 10.2 ESR1 PGR
22 deep angioma 10.2 ESR1 PGR
23 diffuse peritoneal leiomyomatosis 10.2 ESR1 PGR
24 leiomyomatosis 10.2 ESR1 PGR
25 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
26 breast adenoid cystic carcinoma 10.2 ESR1 PGR
27 female reproductive endometrioid cancer 10.2 ESR1 PGR
28 cervical carcinosarcoma 10.2 ESR1 PGR
29 intramuscular hemangioma 10.2 ESR1 PGR
30 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
31 mammographic density 10.2 ESR1 PGR
32 cervical clear cell adenocarcinoma 10.2 ESR1 PGR
33 retinitis pigmentosa 47 10.2 ESR1 PGR
34 inflammatory breast carcinoma 10.2 ESR1 PGR
35 retinitis pigmentosa 20 10.2 ESR1 PGR
36 adenosarcoma 10.2 ESR1 PGR
37 luminal breast carcinoma 10.2 ESR1 PGR
38 postmenopausal atrophic vaginitis 10.2 ESR1 ESR2
39 vaginitis 10.2 ESR1 ESR2
40 breast benign neoplasm 10.2 ESR1 PGR
41 thoracic benign neoplasm 10.2 ESR1 PGR
42 uterine corpus cancer 10.2 ESR1 PGR
43 lipid-rich carcinoma 10.2 ESR1 PGR
44 smooth muscle tumor 10.2 ESR1 PGR
45 uterine benign neoplasm 10.2 ESR1 PGR
46 endometritis 10.2 ESR1 PGR
47 dental fluorosis 10.2 ESR1 ESR2
48 prostatic hypertrophy 10.2 ESR1 PGR
49 lobular neoplasia 10.1 ESR1 ESR2
50 mammary paget's disease 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Progesterone Resistance:



Diseases related to Progesterone Resistance

Symptoms & Phenotypes for Progesterone Resistance

Human phenotypes related to Progesterone Resistance:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 33 HP:0001939
2 female infertility 33 HP:0008222

Symptoms via clinical synopsis from OMIM:

58
G U:
female infertility
normal menstrual cycle
normal luteal phase duration

Lab:
normal plasma immunoreactive lh and progesterone
histologically immature endometrium
decreased endometrial progesterone receptors

Clinical features from OMIM:

264080

MGI Mouse Phenotypes related to Progesterone Resistance:

47 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.21 BCL6 DHCR24 ERRFI1 ESR1 ESR2 FKBP4
2 growth/size/body region MP:0005378 10.2 BCL6 DHCR24 ERRFI1 ESR1 ESR2 FKBP4
3 behavior/neurological MP:0005386 10.19 DHCR24 ERRFI1 ESR1 ESR2 HSD17B2 KRAS
4 homeostasis/metabolism MP:0005376 10.18 BCL6 DHCR24 ERRFI1 ESR1 ESR2 FKBP4
5 cardiovascular system MP:0005385 10.13 BCL6 ERRFI1 ESR1 ESR2 KRAS PGR
6 mortality/aging MP:0010768 10.13 BCL6 DHCR24 ERRFI1 ESR1 ESR2 FKBP4
7 integument MP:0010771 10.1 DHCR24 ERRFI1 ESR1 ESR2 FKBP4 KRAS
8 hematopoietic system MP:0005397 10.08 BCL6 ERRFI1 ESR1 ESR2 KRAS PGR
9 digestive/alimentary MP:0005381 10.05 ERRFI1 ESR1 ESR2 FKBP4 KRAS SIRT1
10 immune system MP:0005387 10.05 BCL6 ERRFI1 ESR1 ESR2 KRAS PGR
11 embryo MP:0005380 10.04 ESR1 FKBP4 HSD17B2 KRAS PGR SIRT1
12 limbs/digits/tail MP:0005371 9.95 ERRFI1 ESR1 ESR2 KRAS PGR SIRT1
13 liver/biliary system MP:0005370 9.93 BCL6 ERRFI1 ESR1 ESR2 KRAS SIRT1
14 no phenotypic analysis MP:0003012 9.91 BCL6 ERRFI1 ESR1 ESR2 KRAS PGR
15 neoplasm MP:0002006 9.88 ERRFI1 ESR1 ESR2 KRAS PGR SIRT1
16 normal MP:0002873 9.87 BCL6 ERRFI1 ESR1 ESR2 KRAS PGR
17 reproductive system MP:0005389 9.81 BCL6 DHCR24 ERRFI1 ESR1 ESR2 FKBP4
18 renal/urinary system MP:0005367 9.8 ERRFI1 ESR1 ESR2 FKBP4 HSD17B2 KRAS
19 respiratory system MP:0005388 9.43 BCL6 ERRFI1 ESR1 ESR2 KRAS SIRT1
20 skeleton MP:0005390 9.02 ERRFI1 ESR1 ESR2 KRAS PGR

Drugs & Therapeutics for Progesterone Resistance

Drugs for Progesterone Resistance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Polyestradiol phosphate Approved Phase 4 28014-46-2
3
Nandrolone phenpropionate Approved, Illicit, Investigational Phase 4 62-90-8 229455
4
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
5
Dienogest Approved Phase 4 65928-58-7
6
Nandrolone Experimental, Investigational Phase 4 434-22-0 9904
7 Androgens Phase 4
8 Estradiol Valerate, dienogest drug combination Phase 4
9 Contraceptive Agents Phase 4
10 Contraceptive Agents, Male Phase 4
11 Hormones Phase 4,Early Phase 1
12 Contraceptives, Oral Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
14 Hormone Antagonists Phase 4,Early Phase 1
15 Anabolic Agents Phase 4
16 Estradiol 17 beta-cypionate Phase 4
17 Estradiol 3-benzoate Phase 4
18 Estrogens Phase 4
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Early Phase 1
20
Progesterone Approved, Vet_approved ,Early Phase 1 57-83-0 5994
21 Progestins ,Early Phase 1
22 Follicle Stimulating Hormone Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Dienogest and Dienogest Plus Estradiol Valerate in Ovarian Endometrioma Recruiting NCT03789123 Phase 4 Estradiol valerate/dienogest
2 Variation of Progesterone in IVF Cycles Recruiting NCT03519776
3 Step Down FSH Approach and Late Follicular Phase in Progesterone Level Recruiting NCT03356964 Early Phase 1 follicle stimulating hormone
4 Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance Not yet recruiting NCT03756480

Search NIH Clinical Center for Progesterone Resistance

Genetic Tests for Progesterone Resistance

Genetic tests related to Progesterone Resistance:

# Genetic test Affiliating Genes
1 Progesterone Resistance 30 PGR

Anatomical Context for Progesterone Resistance

MalaCards organs/tissues related to Progesterone Resistance:

42
Uterus, Placenta, Breast

Publications for Progesterone Resistance

Articles related to Progesterone Resistance:

(show all 31)
# Title Authors Year
1
Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line. ( 30813939 )
2019
2
Progesterone Resistance in Endometriosis: an Acquired Property? ( 29934050 )
2018
3
Progesterone resistance in endometriosis: origins, consequences and interventions. ( 28423456 )
2017
4
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma. ( 28112250 )
2017
5
KRAS Activation and over-expression of SIRT1/BCL6 Contributes to the Pathogenesis of Endometriosis and Progesterone Resistance. ( 28754906 )
2017
6
Progesterone resistance in endometriosis is modulated by the altered expression of microRNA-29c and FKBP4. ( 27778641 )
2016
7
Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma. ( 27402506 )
2016
8
Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis. ( 27075616 )
2016
9
Upregulation of mitogen-inducible gene 6 triggers antitumor effect and attenuates progesterone resistance in endometrial carcinoma cells. ( 26450625 )
2015
10
Endometrial progesterone resistance and PCOS. ( 24405633 )
2014
11
Progesterone receptor isoforms A and B: new insights into the mechanism of progesterone resistance for the treatment of endometrial carcinoma. ( 24386010 )
2013
12
Mechanisms of endometrial progesterone resistance. ( 22085558 )
2012
13
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. ( 21411543 )
2011
14
Progesterone resistance in a baboon model of endometriosis. ( 20104431 )
2010
15
Dioxin and endometrial progesterone resistance. ( 20104429 )
2010
16
Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. ( 20660062 )
2010
17
Progesterone resistance and endometrial disease. Preface. ( 20104423 )
2010
18
Altered gene expression profiling in endometrium: evidence for progesterone resistance. ( 20104428 )
2010
19
17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis. ( 20108182 )
2010
20
Revisiting reproduction: Prematurity and the puzzle of progesterone resistance. ( 20448578 )
2010
21
Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis. ( 20104427 )
2010
22
Endometriosis is associated with progesterone resistance in the baboon (Papio anubis) oviduct: evidence based on the localization of oviductal glycoprotein 1 (OVGP1). ( 18923157 )
2009
23
The altered distribution of the steroid hormone receptors and the chaperone immunophilin FKBP52 in a baboon model of endometriosis is associated with progesterone resistance during the window of uterine receptivity. ( 17636225 )
2007
24
FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific. ( 17571166 )
2007
25
Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. ( 17510236 )
2007
26
Progesterone resistance in endometriosis: link to failure to metabolize estradiol. ( 16406281 )
2006
27
Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) gene. ( 15117941 )
2004
28
Progesterone resistance in women who have had breast cancer. ( 9532998 )
1998
29
Progesterone resistance. ( 3087144 )
1986
30
Pseudocorpus luteum insufficiency: a study of cytosol progesterone receptors in human endometrium. ( 3982727 )
1985
31
Pseudocorpus luteum insufficiency: a local defect of progesterone action on endometrial stroma. ( 217888 )
1979

Variations for Progesterone Resistance

Expression for Progesterone Resistance

Search GEO for disease gene expression data for Progesterone Resistance.

Pathways for Progesterone Resistance

Pathways related to Progesterone Resistance according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 ESR1 ESR2 FKBP4 KRAS PGR
2
Show member pathways
12.4 ESR1 ESR2 KRAS PGR
3
Show member pathways
12.35 ERRFI1 ESR1 ESR2 KRAS
4 11.84 ESR1 KRAS SIRT1
5
Show member pathways
11.72 BCL6 KRAS SIRT1
6
Show member pathways
11.58 ESR1 KRAS PGR
7 11.48 ESR1 ESR2 KRAS
8
Show member pathways
11.29 ESR1 ESR2 PGR
9 11.07 BCL6 ESR1
10 11.03 ESR2 PGR
11 10.96 ESR1 ESR2
12 10.91 ESR1 ESR2
13 10.16 ESR1 ESR2 KRAS
14 9.56 ESR1 ESR2

GO Terms for Progesterone Resistance

Cellular components related to Progesterone Resistance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.1 ESR2 FKBP4 KRAS MIR29C PGR SIRT1

Biological processes related to Progesterone Resistance according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.61 ESR1 ESR2 PGR
2 regulation of cellular response to heat GO:1900034 9.51 FKBP4 SIRT1
3 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 9.49 ESR1 SIRT1
4 lung alveolus development GO:0048286 9.48 ERRFI1 PGR
5 negative regulation of cell-matrix adhesion GO:0001953 9.4 BCL6 MIR29C
6 negative regulation of cellular senescence GO:2000773 9.37 BCL6 SIRT1
7 negative regulation of cell growth GO:0030308 9.33 BCL6 ESR2 SIRT1
8 intracellular estrogen receptor signaling pathway GO:0030520 9.32 ESR1 ESR2
9 positive regulation of cellular senescence GO:2000774 9.26 KRAS SIRT1
10 transcription, DNA-templated GO:0006351 9.16 ESR1
11 ovulation from ovarian follicle GO:0001542 8.96 PGR SIRT1
12 negative regulation of gene expression GO:0010629 8.92 ESR1 MIR29C PGR SIRT1

Molecular functions related to Progesterone Resistance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 BCL6 ESR1 ESR2 PGR SIRT1
2 sequence-specific DNA binding GO:0043565 9.73 BCL6 ESR1 ESR2 PGR
3 steroid hormone receptor activity GO:0003707 9.43 ESR1 ESR2 PGR
4 estrogen receptor activity GO:0030284 9.37 ESR1 ESR2
5 enzyme binding GO:0019899 9.35 DHCR24 ESR1 ESR2 PGR SIRT1
6 nuclear receptor activity GO:0004879 9.33 ESR1 ESR2 PGR
7 estrogen response element binding GO:0034056 9.32 ESR1 ESR2
8 steroid binding GO:0005496 8.8 ESR1 ESR2 PGR

Sources for Progesterone Resistance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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