Progressive Bulbar Palsy

External Ids:

Disease Ontology 12 DOID:681 ICD10 33 G12.22 ICD9CM 35 335.22 MeSH 44 D010244

NCIt 50 C85026 SNOMED-CT 68 230547002 54304004 UMLS 73 C0030442

NIH Rare Diseases : ⁵³ Progressive bulbar palsy involves the brain stem. The brain stem is the part of the brain needed for swallowing, speaking, chewing, and other functions. Signs and symptoms of progressive bulbar palsy include difficulty swallowing, weak jaw and facial muscles, progressive loss of speech, and weakening of the tongue. Additional symptoms include less prominent weakness in the arms and legs, and outbursts of laughing or crying (called emotional lability). Progressive bulbar palsy is considered a variant form of amyotrophic lateral sclerosis (ALS). Many people with progressive bulbar palsy later develop ALS. While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms.

MalaCards based summary : Progressive Bulbar Palsy, also known as bulbar palsy, progressive, is related to fazio-londe disease and motor neuron disease. An important gene associated with Progressive Bulbar Palsy is SLC52A3 (Solute Carrier Family 52 Member 3). Affiliated tissues include brain, tongue and spinal cord, and related phenotype is Increased cell death HMECs cells.

Wikipedia : ⁷⁶ Progressive bulbar palsy (PBP) is a medical condition. It belongs to a group of disorders known as motor... more...

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death HMECs cells	GR00103-A-0	8.92	GSTP1 MUSK TF TNFRSF10A

Search NIH Clinical Center for Progressive Bulbar Palsy

Search GEO for disease gene expression data for Progressive Bulbar Palsy.