MCID: PRG077
MIFTS: 22

Progressive Nodular Histiocytosis

Categories: Bone diseases, Skin diseases, Rare diseases

Aliases & Classifications for Progressive Nodular Histiocytosis

MalaCards integrated aliases for Progressive Nodular Histiocytosis:

Name: Progressive Nodular Histiocytosis 59

Characteristics:

Orphanet epidemiological data:

59
progressive nodular histiocytosis
Inheritance: Not applicable;

Classifications:



External Ids:

Orphanet 59 ORPHA158022
ICD10 via Orphanet 34 D76.3

Summaries for Progressive Nodular Histiocytosis

MalaCards based summary : Progressive Nodular Histiocytosis is related to histiocytosis and laryngitis. An important gene associated with Progressive Nodular Histiocytosis is ACTC1 (Actin, Alpha, Cardiac Muscle 1). Affiliated tissues include skin and bone, and related phenotypes are subcutaneous nodule and fever

Wikipedia : 76 Progressive nodular histiocytosis is a cutaneous condition clinically characterized by the development... more...

Related Diseases for Progressive Nodular Histiocytosis

Diseases related to Progressive Nodular Histiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 10.4
2 laryngitis 9.9
3 juvenile xanthogranuloma 9.8
4 scleromyxedema 9.6 ACTC1 F13A1
5 fibroblastic rheumatism 9.6 ACTC1 F13A1
6 angiolipoma 9.6 ACTC1 F13A1
7 cutaneous fibrous histiocytoma 9.5 ACTC1 F13A1
8 non-langerhans-cell histiocytosis 9.5 ACTC1 F13A1
9 hemangiopericytoma, malignant 9.4 ACTC1 F13A1
10 malignant fibroxanthoma 9.3 ACTC1 F13A1
11 fibrous histiocytoma 9.2 ACTC1 F13A1
12 dermatofibrosarcoma protuberans 9.0 ACTC1 F13A1

Graphical network of the top 20 diseases related to Progressive Nodular Histiocytosis:



Diseases related to Progressive Nodular Histiocytosis

Symptoms & Phenotypes for Progressive Nodular Histiocytosis

Human phenotypes related to Progressive Nodular Histiocytosis:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
2 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
3 cachexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0004326
4 papule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200034

Drugs & Therapeutics for Progressive Nodular Histiocytosis

Search Clinical Trials , NIH Clinical Center for Progressive Nodular Histiocytosis

Genetic Tests for Progressive Nodular Histiocytosis

Anatomical Context for Progressive Nodular Histiocytosis

MalaCards organs/tissues related to Progressive Nodular Histiocytosis:

41
Skin, Bone

Publications for Progressive Nodular Histiocytosis

Articles related to Progressive Nodular Histiocytosis:

(show all 17)
# Title Authors Year
1
A Case with Juvenile Xanthogranuloma and Progressive Nodular Histiocytosis Overlap. ( 28297144 )
2017
2
Progressive nodular histiocytosis improved by methotrexate. ( 29165296 )
2017
3
Laryngeal involvement with fatal outcome in progressive nodular histiocytosis: A rare case report. ( 27990389 )
2016
4
Progressive Nodular Histiocytosis Associated with Eale's Disease. ( 26288410 )
2015
5
Effective surgical treatment of progressive nodular histiocytosis. ( 24428162 )
2014
6
Reddish-brown nodules and papules in an elderly man. Progressive nodular histiocytosis. ( 23945611 )
2013
7
Progressive nodular histiocytosis. ( 23231636 )
2013
8
Progressive nodular histiocytosis with normal karyotypic analysis. ( 24011326 )
2013
9
Progressive nodular histiocytosis: a case report and literature review. ( 22098005 )
2011
10
Progressive nodular histiocytosis. ( 21083716 )
2010
11
Laryngeal involvement in progressive nodular histiocytosis: a case report. ( 20479385 )
2010
12
Progressive nodular histiocytosis: a case report with literature review, and discussion of differential diagnosis and classification. ( 19878386 )
2009
13
Progressive nodular histiocytosis - A five-year follow up. ( 18424392 )
2008
14
Progressive nodular histiocytosis in a child with a hypothalamic tumor. ( 11852916 )
2002
15
Progressive nodular histiocytosis accompanied by systemic disorders. ( 10971342 )
2000
16
Solitary and generalized variants of spindle cell xanthogranuloma (progressive nodular histiocytosis). ( 7557901 )
1995
17
Progressive nodular histiocytosis. ( 8335756 )
1993

Variations for Progressive Nodular Histiocytosis

Expression for Progressive Nodular Histiocytosis

Search GEO for disease gene expression data for Progressive Nodular Histiocytosis.

Pathways for Progressive Nodular Histiocytosis

GO Terms for Progressive Nodular Histiocytosis

Cellular components related to Progressive Nodular Histiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.62 ACTC1 F13A1

Sources for Progressive Nodular Histiocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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