MCID: PRG080
MIFTS: 35

Progressive Non-Infectious Anterior Vertebral Fusion

Categories: Bone diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Progressive Non-Infectious Anterior Vertebral Fusion

MalaCards integrated aliases for Progressive Non-Infectious Anterior Vertebral Fusion:

Name: Progressive Non-Infectious Anterior Vertebral Fusion 58 29
Copenhagen Syndrome 58
Copenhagen 17

Characteristics:

Orphanet epidemiological data:

58
progressive non-infectious anterior vertebral fusion
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: any age;

Classifications:

Orphanet: 58  
Rare bone diseases
Developmental anomalies during embryogenesis


Summaries for Progressive Non-Infectious Anterior Vertebral Fusion

MalaCards based summary : Progressive Non-Infectious Anterior Vertebral Fusion, also known as copenhagen syndrome, is related to adenoid hypertrophy and stroke, ischemic. The drugs Naltrexone and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart, and related phenotypes are depressed nasal bridge and hypertelorism

Wikipedia : 74 Copenhagen disease, sometimes known as Copenhagen syndrome, refers to progressive non-infectious... more...

Related Diseases for Progressive Non-Infectious Anterior Vertebral Fusion

Diseases related to Progressive Non-Infectious Anterior Vertebral Fusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 419)
# Related Disease Score Top Affiliating Genes
1 adenoid hypertrophy 11.3
2 stroke, ischemic 10.4
3 poliomyelitis 10.4
4 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
5 coronary heart disease 1 10.2
6 osteoarthritis 10.2
7 atrial fibrillation 10.2
8 liver disease 10.2
9 cerebrovascular disease 10.2
10 pulmonary disease, chronic obstructive 10.2
11 syphilis 10.2
12 alcohol dependence 10.2
13 bladder cancer 10.2
14 adenocarcinoma 10.2
15 spinal disease 10.2
16 situs inversus 10.2
17 fetal thalidomide syndrome 10.2
18 cardiac arrest 10.1
19 dermatitis 10.1
20 ulcerative colitis 10.1
21 in situ carcinoma 10.1
22 crohn's disease 10.1
23 acute myocardial infarction 10.1
24 headache 10.1
25 lipoprotein quantitative trait locus 10.1
26 salmonellosis 10.1
27 heart disease 10.1
28 transient cerebral ischemia 10.1
29 angina pectoris 10.1
30 inflammatory bowel disease 10.1
31 hepatitis a 10.1
32 viral hepatitis 10.1
33 congestive heart failure 10.1
34 peptic ulcer disease 10.1
35 47,xyy 10.1
36 schizophrenia 10.1
37 immune deficiency disease 10.1
38 allergic rhinitis 10.1
39 myocardial infarction 10.1
40 aphasia 10.1
41 chlamydia 10.1
42 personality disorder 10.1
43 duodenal ulcer 10.1
44 dental caries 10.1
45 papilloma 10.1
46 rhinitis 10.1
47 measles 10.1
48 hypercholesterolemia, familial, 1 10.0
49 thrombophilia due to thrombin defect 10.0
50 body mass index quantitative trait locus 1 10.0

Graphical network of the top 20 diseases related to Progressive Non-Infectious Anterior Vertebral Fusion:



Diseases related to Progressive Non-Infectious Anterior Vertebral Fusion

Symptoms & Phenotypes for Progressive Non-Infectious Anterior Vertebral Fusion

Human phenotypes related to Progressive Non-Infectious Anterior Vertebral Fusion:

58 31 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depressed nasal bridge 58 31 hallmark (90%) Very frequent (99-80%) HP:0005280
2 hypertelorism 58 31 hallmark (90%) Very frequent (99-80%) HP:0000316
3 scoliosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002650
4 kyphosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002808
5 wide nasal bridge 58 31 hallmark (90%) Very frequent (99-80%) HP:0000431
6 brachycephaly 58 31 hallmark (90%) Very frequent (99-80%) HP:0000248
7 flat face 58 31 hallmark (90%) Very frequent (99-80%) HP:0012368
8 thickened skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0001072
9 micrognathia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000347
10 wide mouth 58 31 hallmark (90%) Very frequent (99-80%) HP:0000154
11 downslanted palpebral fissures 58 31 hallmark (90%) Very frequent (99-80%) HP:0000494
12 hemivertebrae 58 31 hallmark (90%) Very frequent (99-80%) HP:0002937
13 short philtrum 58 31 hallmark (90%) Very frequent (99-80%) HP:0000322
14 round face 58 31 hallmark (90%) Very frequent (99-80%) HP:0000311
15 thin vermilion border 58 31 hallmark (90%) Very frequent (99-80%) HP:0000233
16 large hands 58 31 hallmark (90%) Very frequent (99-80%) HP:0001176
17 abnormality of the intervertebral disk 58 31 hallmark (90%) Very frequent (99-80%) HP:0005108
18 joint stiffness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001387
19 spinal rigidity 58 31 occasional (7.5%) Occasional (29-5%) HP:0003306
20 abdominal situs inversus 58 31 occasional (7.5%) Occasional (29-5%) HP:0003363
21 exostoses 58 31 occasional (7.5%) Occasional (29-5%) HP:0100777
22 tall stature 58 31 occasional (7.5%) Occasional (29-5%) HP:0000098
23 proximal radio-ulnar synostosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0005037
24 bone pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002653
25 morphological central nervous system abnormality 31 occasional (7.5%) HP:0002011
26 abnormal facial shape 58 Occasional (29-5%)
27 abnormality of the vertebral column 58 Very frequent (99-80%)
28 morphological abnormality of the central nervous system 58 Occasional (29-5%)

Drugs & Therapeutics for Progressive Non-Infectious Anterior Vertebral Fusion

Drugs for Progressive Non-Infectious Anterior Vertebral Fusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 319)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
2
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
4
Polyestradiol phosphate Approved Phase 4 28014-46-2
5
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
6
Glucagon Approved Phase 4 16941-32-5
7
Ibuprofen Approved Phase 4 15687-27-1 3672
8
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
9
Magnesium oxide Approved Phase 4 1309-48-4 14792
10
Ethanol Approved Phase 4 64-17-5 702
11
Levetiracetam Approved Phase 4 102767-28-2 441341
12
Selenium Approved, Investigational, Vet_approved Phase 4 7782-49-2
13
leucovorin Approved Phase 4 58-05-9 6006 143
14
Zinc Approved, Investigational Phase 4 7440-66-6 32051
15
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
16
Morphine Approved, Investigational Phase 4 57-27-2 5288826
17
Iodine Approved, Investigational Phase 4 7553-56-2 807
18
Simvastatin Approved Phase 4 79902-63-9 54454
19
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
20
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
21
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
22
Copper Approved, Investigational Phase 4 7440-50-8 27099
23
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
24
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173 46783403
25
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
26
Liraglutide Approved Phase 4 204656-20-2 44147092
27
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
28
Insulin aspart Approved Phase 4 116094-23-6 16132418
29
Pancrelipase Approved, Investigational Phase 4 53608-75-6
30
Atorvastatin Approved Phase 4 134523-00-5 60823
31
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
32
Rivaroxaban Approved Phase 4 366789-02-8
33
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
34
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
35
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
36
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
37
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
38
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
39
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 59-43-8, 70-16-6 1130
40
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
41
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
42
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
43 Tocotrienol Investigational Phase 4 6829-55-6
44
Cobalamin Experimental Phase 4 13408-78-1 6857388
45 Narcotic Antagonists Phase 4
46 Hormones Phase 4
47 Anesthetics Phase 4
48 Soy Bean Phase 4
49 Estradiol 17 beta-cypionate Phase 4
50 Progestins Phase 4

Interventional clinical trials:

(show top 50) (show all 381)
# Name Status NCT ID Phase Drugs
1 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
2 Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery Unknown status NCT02270723 Phase 4 5% Human Albumin " Behring";Lactated Ringer
3 Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being Unknown status NCT02796378 Phase 4 Training+Simvastatin+Q10-placebo;Training+Simvastatin-placebo+Q10-placebo;Training+Simvastatin+Q10
4 The Luteal Phase After GnRHa Trigger - a Proof of Concept Study Completed NCT01504139 Phase 4 hCG(r-hCG, Ovitrelle, Merck-Serono, Hellerup, Denmark) in the late follicular phase + luteal phase;hCG(r-hCG, Ovitrelle,Merck-Serono, Hellerup, Denmark) in the follicular phase + luteal phase;LH(r-LH,Luveris, Merck-Serono, Hellerup, Denmark) in the luteal phase;vaginal progesterone(Crinone; Merck-Serono, Hellerup, Denmark) and estradiol(Estrofem; Novo Nordisk, Copenhagen, Denmark) in the luteal phase
5 Pain Management After Cardiac Surgery - Opioids or NSAID? A Randomized Prospective Study Completed NCT02479165 Phase 4 Ibuprofene;Oxycodone
6 Effects of Photodynamic Therapy on Clinical and Immunological Parameters in a Group of Periodontal Patients Undergoing Supportive Periodontal Therapy Completed NCT02666573 Phase 4
7 Effects of Levetiracetam on Chronic Neuropathic Pain Following Spinal Cord Injury: a Randomized, Double-blind, Placebo-controlled, Cross-over, Multi-center Study Completed NCT00252954 Phase 4 Levetiracetam
8 Ophthalmic Findings During 10-year Enzyme Substitution of Danish Fabry Patients Completed NCT01997489 Phase 4 Enzyme replacement
9 Short Term Physiological Effects of Nasal High Oxygen Flow vs Low Oxygen Flow and Noninvasive Ventilation (NIV) on Respiratory Mechanics Completed NCT02363920 Phase 4
10 Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being Completed NCT02255682 Phase 4 Simvastatin
11 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
12 Ultrasound-guided Transmuscular Quadratus Lumborum Block for Laparoscopic Hysterectomy. A Double Blind, Randomized, Placebo Controlled Trial. Completed NCT03650998 Phase 4 Ropivacaine;Saline
13 Multicenter, Randomised Study of the Use of Non-Invasive Ventilation (NIV) Versus Oxygen Therapy (O2) in Reducing Dyspnea in End-stage Solid Cancer Patients With Respiratory Failure and Distress Completed NCT00533143 Phase 4
14 Intestinal Decontamination With Rifaximin. Effects on the Inflammatory and Circulatory State in Patients With Cirrhosis and Ascites - A Randomised Controlled Clinical Study Completed NCT01769040 Phase 4 Rifaximin;placebo
15 Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome: A Randomized, Double Blind, Parallel Group, Flexible Dose, Placebo Controlled Trial. Completed NCT00610610 Phase 4 Paroxetine CR;Placebo
16 Effect of Prenatal Nutritional Supplementation on Birth Outcome in Hounde District, Burkina Faso Completed NCT00909974 Phase 4
17 Effect of Glucagon-like Peptide-1 Stimulation on Coronary Microvascular Dysfunction in Women With Angina Pectoris and no Obstructive Stenosis of Major Coronary Vessels Completed NCT02602600 Phase 4 Liraglutide
18 AID-trial:A Randomized Clinical Trial Comparing the Effect on Repeated Self-harm of Assertive Intervention and Standard Treatment After Deliberate Self-harm Completed NCT00700089 Phase 4
19 Oral Potassium Supplementation in Healthy Men - Interactions With the Renin-angiotensin-aldosterone System and the Sympathetic Nervous System Completed NCT02380157 Phase 4 Kaleorid, 750mg (trade name), Potassium chloride (active substance);Placebo
20 A Randomized, Double-blind, Placebo Controlled, Parallel, Multicenter Study of the Effects of 12-weeks of Sodium Zirconium Cyclosilicate (Lokelma) on Albuminuria (UACR) in Patients With Type 2 Diabetes and Hyperkalemia Recruiting NCT04063930 Phase 4 LOKELMA 5 GM Powder for Oral Suspension;Placebos
21 Comparison of Two Induction Regimens Using Topical Lidocaine or Muscle Relaxant; Impact on Postoperative Sore Throat and Haemodynamics Recruiting NCT03031808 Phase 4 Lidocaine spray (2%);Muscle Relaxant (Rocuronium)
22 The Effect of Allergen Immunotherapy on Anti-viral Immunity in Patients With Allergic Asthma - A Randomized, Double-blind, Placebo-controlled Trial of HDM-AIT Recruiting NCT04100902 Phase 4 ODACTRA 12 SQ-HDM Sublingual Tablet;Placebo sublingual tablet
23 Dual-hormone Closed-loop Glucose Control in Type 1 Diabetes Recruiting NCT04053712 Phase 4 Glucagon
24 Statins for Prevention of Disease Progression and Hospitalization in Liver Cirrhosis: A Multi-center, Randomized, Double Blind, Placebo-controlled Trial. The STATLiver Trial Recruiting NCT04072601 Phase 4 Placebo oral tablet;Atorvastatin 10mg
25 Randomized Trial of Aspirin Versus Rivaroxaban After Replacement of the Aortic Valve With a Biological Valve Prosthesis Recruiting NCT02974920 Phase 4 Rivaroxaban 10 MG;Aspirin
26 Acute Effects of Sodium-glucose Cotransporter-2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes Not yet recruiting NCT04193566 Phase 4 Forxiga
27 Multicentre Randomized Trial Assessing the Impact of Maintaining 2 Blood Glucose Levels on Hospital Mortality in Patients Admitted to the ICU (INSUREA STUDY) Unknown status NCT00591071 Phase 3
28 Anti-IL-17 a New Treatment for Contact Dermatititis Unknown status NCT02778711 Phase 3 secukinumab
29 Comparison of a Fixed-Schedule Therapy Versus a Symptom-Triggered Therapy for Alcohol Withdrawal Syndrome in Medical Out-Patients Completed NCT00136617 Phase 3 chlordiazepoxide
30 Succinylcholine vs Rocuronium for Prehospital Emergency Intubation : a Randomized Trial Completed NCT02000674 Phase 3 Succinylcholine : 1mg/kg;Rocuronium : 1.2 mg/kg
31 The Effect of i.v. Bisphosphonate on Health-Related Quality of Life and Skeletal Morbidity for Newly Diagnosed Treatment Demanding Multiple Myeloma. A Prospective Randomised Double Blinded Dose-Effective Study With Cost-Utility Analysis. Completed NCT00376883 Phase 3 pamidronate
32 Weight Loss Maintenance of a New Bioactive Compound (Metobes-Long) Completed NCT00302276 Phase 2, Phase 3 Metobes-compound
33 ExStroke Pilot Trial: Physical Exercise After Acute Ischaemic Stroke Completed NCT00132483 Phase 3
34 Family and Coping Oriented Palliative Homecare Nursing as a Supplement to Standard Homecare Nursing Aimed at Advanced Cancer Patients - a Randomized Intervention Trial Completed NCT01444157 Phase 3
35 Cognitive Function and Addiction in Patients With Chronic Pain Under Opioid Tapering in a Multidisciplinary Pain Treatment Completed NCT03365817 Phase 3 Opioids taper off;Opioid stable treatment
36 A Prospective, Randomized Controlled Trial of Mindfulness-based Stress Reduction (MBSR) Among Women Operated for Breast Cancer Completed NCT00990977 Phase 2, Phase 3
37 Vitamin D Supplementation and Male Infertility: The Copenhagen Bone-Gonadal Study a Double Blinded Randomized Clinical Trial Completed NCT01304927 Phase 2, Phase 3 Cholecalciferol and calcium
38 NEUROCOM: Cognitive Training for Patients With First Episode Schizophrenia Completed NCT00472862 Phase 3
39 Treatment of Traumatised Refugees: the Effect of Basic Body Awareness Therapy Versus Mixed Physical Activity as add-on Treatment. A Randomised Controlled Trial. Completed NCT01955538 Phase 3
40 Effects of the PCSK9 Antibody AliroCuMab on Coronary Atherosclerosis in PatieNts With Acute Myocardial Infarction: A Serial, Multivessel, Intravascular Ultrasound, Near-Infrared Spectroscopy And Optical Coherence Tomography Imaging Study Recruiting NCT03067844 Phase 3 Alirocumab
41 Application of BCG Vaccine for Immune-prophylaxis Among Egyptian Healthcare Workers During the Pandemic of COVID-19 Not yet recruiting NCT04350931 Phase 3
42 Using BCG Vaccine to Enhance Non-specific Protection of Health Care Workers During the COVID-19 Pandemic. A Randomized Controlled Multi-center Trial Not yet recruiting NCT04373291 Phase 3
43 PRESS Pathogen Reduction Extended Storage Study PRESS (Pathogen Reduction Extended Storage Study) A Pilot Study of Mirasol Platelets Treated in Platelet Additive Solution in Thrombocytopenic Patients Terminated NCT01368211 Phase 2, Phase 3
44 Rosiglitazone and Insulin Resistance in Renally Impaired Patients Terminated NCT00452166 Phase 3 rosiglitazone
45 Electrochemotherapy on Head and Neck Cancer Unknown status NCT02549742 Phase 2 Bleomycin
46 The Effect of Medical Cannabis Inpatients With Palliative Pancreatic Cancer Unknown status NCT03245658 Phase 2 THC and CBD Mixture
47 The Effect of Triheptanoin in Adults With Mc Ardle Disease (Glycogen Storage Disease Type V) Unknown status NCT02919631 Phase 2 Triheptanoin;Placebo oil
48 Impact of the 7 Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. Pneumoniae in Healthy Jordanian Infants. Unknown status NCT00900978 Phase 1, Phase 2
49 The Øresund Copenhagen-Malmø Acute Stroke Cooling Trial Completed NCT01500421 Phase 2
50 The Effect of Rehabilitation for Patients Living With an ICD Completed NCT00569478 Phase 2

Search NIH Clinical Center for Progressive Non-Infectious Anterior Vertebral Fusion

Genetic Tests for Progressive Non-Infectious Anterior Vertebral Fusion

Genetic tests related to Progressive Non-Infectious Anterior Vertebral Fusion:

# Genetic test Affiliating Genes
1 Progressive Non-Infectious Anterior Vertebral Fusion 29

Anatomical Context for Progressive Non-Infectious Anterior Vertebral Fusion

MalaCards organs/tissues related to Progressive Non-Infectious Anterior Vertebral Fusion:

40
Liver, Testes, Heart, Bone, Breast, Brain, Spinal Cord

Publications for Progressive Non-Infectious Anterior Vertebral Fusion

Articles related to Progressive Non-Infectious Anterior Vertebral Fusion:

# Title Authors PMID Year
1
Turning the backbone into an ankylosed concrete-like structure: Case report. 61
29642148 2018
2
Clinical Images: Progressive Noninfectious Anterior Vertebral Fusion (Copenhagen Syndrome) in a 15-Year-Old Boy. 61
28235247 2017
3
Long-term clinical and radiological outcomes of Copenhagen syndrome with 19 affected levels: a case report. 61
25485486 2015
4
Progressive non-infectious anterior vertebral fusion, split cord malformation and situs inversus visceralis. 61
17147792 2006
5
Progressive non-infectious anterior vertebral fusion (Copenhagen Syndrome) in three children: features on radiographs and MR imaging. 61
16328382 2006
6
Progressive non-infectious anterior vertebral fusion ('Copenhagen disease'). 61
11858144 2002
7
Progressive non-infectious anterior vertebral fusion. 61
3810179 1986

Variations for Progressive Non-Infectious Anterior Vertebral Fusion

Expression for Progressive Non-Infectious Anterior Vertebral Fusion

Search GEO for disease gene expression data for Progressive Non-Infectious Anterior Vertebral Fusion.

Pathways for Progressive Non-Infectious Anterior Vertebral Fusion

GO Terms for Progressive Non-Infectious Anterior Vertebral Fusion

Sources for Progressive Non-Infectious Anterior Vertebral Fusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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