MCID: PRG090
MIFTS: 27

Progressive Relapsing Multiple Sclerosis

Categories: Neuronal diseases

Aliases & Classifications for Progressive Relapsing Multiple Sclerosis

MalaCards integrated aliases for Progressive Relapsing Multiple Sclerosis:

Name: Progressive Relapsing Multiple Sclerosis 12 15
Multiple Sclerosis, Progressive Relapsing 73
Progressive-Relapsing Ms 12
Prms 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050785
MeSH 44 D020528
SNOMED-CT 68 230374002
UMLS 73 C0393666

Summaries for Progressive Relapsing Multiple Sclerosis

Disease Ontology : 12 A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset.

MalaCards based summary : Progressive Relapsing Multiple Sclerosis, also known as multiple sclerosis, progressive relapsing, is related to encephalitis and japanese encephalitis. An important gene associated with Progressive Relapsing Multiple Sclerosis is FCN1 (Ficolin 1), and among its related pathways/superpathways are Innate Immune System and Complement and coagulation cascades. The drugs Adrenocorticotropic Hormone and beta-endorphin have been mentioned in the context of this disorder.

Related Diseases for Progressive Relapsing Multiple Sclerosis

Diseases related to Progressive Relapsing Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 encephalitis 10.4
2 japanese encephalitis 10.3
3 tick-borne encephalitis 10.1
4 west nile virus 9.9
5 murray valley encephalitis 9.9
6 vaccinia 9.9
7 reproductive system disease 9.9 PGR PRM2
8 multiple sclerosis 9.9
9 leiomyoma, uterine 9.8
10 osteoporosis 9.8
11 dengue virus 9.8
12 osteoarthritis 9.8
13 louping ill 9.8
14 st. louis encephalitis 9.8
15 leiomyoma 9.8
16 rhabdomyosarcoma 9.8
17 rheumatic heart disease 9.3 MASP2 MBL2
18 iga glomerulonephritis 9.1 MASP1 MBL2
19 3mc syndrome 8.9 MASP1 MASP2 MBL2
20 mannose-binding lectin deficiency 8.7 FCN1 FCN3 MASP2 MBL2
21 rheumatic fever 8.4 FCN1 FCN2 FCN3 MASP2 MBL2

Graphical network of the top 20 diseases related to Progressive Relapsing Multiple Sclerosis:



Diseases related to Progressive Relapsing Multiple Sclerosis

Symptoms & Phenotypes for Progressive Relapsing Multiple Sclerosis

Drugs & Therapeutics for Progressive Relapsing Multiple Sclerosis

Drugs for Progressive Relapsing Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Adrenocorticotropic Hormone Phase 2
2 beta-endorphin Phase 2
3 Hormone Antagonists Phase 2
4 Hormones Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
6 Melanocyte-Stimulating Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ACTH in Progressive Forms of MS Recruiting NCT01950234 Phase 2 ACTH;Placebo
2 Autologous Mesenchymal Stem Cell (MSC) Transplantation in MS Completed NCT00813969 Phase 1

Search NIH Clinical Center for Progressive Relapsing Multiple Sclerosis

Genetic Tests for Progressive Relapsing Multiple Sclerosis

Anatomical Context for Progressive Relapsing Multiple Sclerosis

Publications for Progressive Relapsing Multiple Sclerosis

Articles related to Progressive Relapsing Multiple Sclerosis:

# Title Authors Year
1
Clinical characteristics of progressive relapsing multiple sclerosis. ( 15327045 )
2004
2
A cost-utility analysis of mitoxantrone hydrochloride and interferon beta-1b in the treatment of patients with secondary progressive or progressive relapsing multiple sclerosis. ( 12749517 )
2003

Variations for Progressive Relapsing Multiple Sclerosis

Expression for Progressive Relapsing Multiple Sclerosis

Search GEO for disease gene expression data for Progressive Relapsing Multiple Sclerosis.

Pathways for Progressive Relapsing Multiple Sclerosis

GO Terms for Progressive Relapsing Multiple Sclerosis

Cellular components related to Progressive Relapsing Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2
2 collagen trimer GO:0005581 8.92 FCN1 FCN2 FCN3 MBL2

Biological processes related to Progressive Relapsing Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2
2 immune system process GO:0002376 9.8 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2
3 innate immune response GO:0045087 9.7 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2
4 defense response to Gram-positive bacterium GO:0050830 9.61 FCN2 MBL2 NOD1
5 recognition of apoptotic cell GO:0043654 9.5 FCN1 FCN2 FCN3
6 negative regulation of viral entry into host cell GO:0046597 9.46 FCN1 FCN3
7 complement activation GO:0006956 9.43 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2
8 opsonization GO:0008228 9.4 FCN2 MBL2
9 complement activation, lectin pathway GO:0001867 9.1 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2

Molecular functions related to Progressive Relapsing Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 ATN1 FCN1 FCN2 FCN3 MASP1 MASP2
2 carbohydrate binding GO:0030246 9.46 FCN1 FCN2 FCN3 MBL2
3 calcium-dependent protein binding GO:0048306 9.26 FCN2 MASP1 MASP2 MBL2
4 serine-type endopeptidase activity GO:0004252 9.1 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2

Sources for Progressive Relapsing Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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