MCID: PRL010
MIFTS: 40

Prolactin Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

MalaCards integrated aliases for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 12 15
Prolactin-Producing Pituitary Gland Carcinoma 12 73
Prolactin-Producing Pituitary Tumor 55 73
Malignant Prolactin Producing Neoplasm of Pituitary Gland 12
Prolactin Secreting Tumor of Pituitary 12
Malignant Prolactinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5396
NCIt 50 C5962 C7910

Summaries for Prolactin Producing Pituitary Tumor

Disease Ontology : 12 A pituitary carcinoma that is located in the anterior lobe of the pituitary gland that produces prolactin.

MalaCards based summary : Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary gland carcinoma, is related to pituitary tumors and galactorrhea. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Neuroscience. The drugs Hormones and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include the anterior lobe of the pituitary gl, pituitary and brain, and related phenotypes are behavior/neurological and integument

Related Diseases for Prolactin Producing Pituitary Tumor

Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 30.9 PRL SST
2 galactorrhea 30.7 DRD2 PRL
3 schizophreniform disorder 10.6 DRD2 PRL
4 social phobia 10.6 DRD2 PRL
5 peripartum cardiomyopathy 10.5 DRD2 PRL
6 pituitary infarct 10.5 PRL SST
7 tsh producing pituitary tumor 10.5 PRL SST
8 chiasmal syndrome 10.5 PRL SST
9 pituitary adenoma 1, multiple types 10.4 PRL SST
10 pituitary carcinoma 10.4 PRL SST
11 migraine without aura 10.4 DRD2 PRL
12 nelson syndrome 10.4 PRL SST
13 hyperpituitarism 10.4 PRL SST
14 cocaine abuse 10.4 DRD2 PRL
15 growth hormone secreting pituitary adenoma 10.4 PRL SST
16 adrenal cortex disease 10.4 PRL SST
17 adrenal gland disease 10.4 PRL SST
18 neuropathy, hereditary sensory and autonomic, type v 10.3 NGF NTRK1
19 pituitary-dependent cushing's disease 10.3 PRL SST
20 askin's tumor 10.3 NGF NTRK1
21 endocrine organ benign neoplasm 10.3 PRL SST
22 traumatic brain injury 10.3 DRD2 NGF
23 conjunctival nevus 10.3 NGF NTRK1
24 central nervous system organ benign neoplasm 10.3 PRL TP53
25 sweat gland disease 10.3 NGF NTRK1
26 mccune-albright syndrome 10.2 PRL SST
27 cortical thymoma 10.2 NGF SST
28 granulosa cell tumor of the ovary 10.2 PRL TP53
29 adrenal gland hyperfunction 10.2 PRL SST
30 chromophobe adenoma 10.2 PRL TP53
31 anhidrosis 10.2 NGF NTRK1
32 opiate dependence 10.2 DRD2 NGF
33 ocular cicatricial pemphigoid 10.2 NGF NTRK1
34 pituitary gland disease 10.2 PRL SST
35 cerebral cavernous malformations 2 10.1 NGF NTRK1
36 substance abuse 10.1 DRD2 PRL
37 phaeochromocytoma 10.1 NGF SST
38 cerebral neuroblastoma 10.1 NGF TP53
39 ependymoblastoma 10.1 NGF TP53
40 meningeal melanomatosis 10.1 NGF TP53
41 hereditary sensory neuropathy 10.1 NGF NTRK1
42 ovarian cystic teratoma 10.0 CALCA PRL
43 functioning pituitary adenoma 10.0 DRD2 PRL SST
44 hyperprolactinemia 10.0 DRD2 PRL SST
45 pituitary adenoma, prolactin-secreting 10.0 DRD2 PRL SST
46 wdha syndrome 9.9 CALCA SST
47 algoneurodystrophy 9.9 CALCA NGF
48 pancreatic somatostatinoma 9.9 CALCA SST
49 duodenal somatostatinoma 9.9 CALCA SST
50 goiter 9.9

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to Prolactin Producing Pituitary Tumor

Symptoms & Phenotypes for Prolactin Producing Pituitary Tumor

MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 NTRK1 PRL SST TP53 DRD2 TYRP1
2 integument MP:0010771 9.85 NTRK1 PRL TP53 DRD2 TYRP1 NGF
3 nervous system MP:0003631 9.8 NTRK1 PRL SST TP53 DRD2 TYRP1
4 neoplasm MP:0002006 9.62 PRL TP53 DRD2 TYRP1
5 no phenotypic analysis MP:0003012 9.55 NTRK1 SST TP53 DRD2 NGF
6 normal MP:0002873 9.35 NGF NTRK1 SST TP53 DRD2
7 pigmentation MP:0001186 8.92 NTRK1 TP53 DRD2 TYRP1

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
3
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
4 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
5 Gastrointestinal Agents Phase 1
6 Edotreotide Phase 1
7 Radiopharmaceuticals Phase 1
8 Antineoplastic Agents, Hormonal Phase 1
9 Hormone Antagonists Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
11 phenylalanine Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1
5 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

Anatomical Context for Prolactin Producing Pituitary Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Prolactin Producing Pituitary Tumor:

19
The Anterior Lobe Of The Pituitary Gl

MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

41
Pituitary, Brain

Publications for Prolactin Producing Pituitary Tumor

Articles related to Prolactin Producing Pituitary Tumor:

# Title Authors Year
1
[Prolactin producing pituitary tumor]. ( 11808216 )
2001
2
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". ( 9531902 )
1998
3
Estrogen induction of prolactin-producing pituitary tumors in the Fischer 344 rat: modulation by dietary-energy but not protein consumption. ( 9808163 )
1998
4
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. ( 9808162 )
1998
5
Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. ( 9500197 )
1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. ( 7714616 )
1995
7
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. ( 2570719 )
1989
8
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. ( 7098479 )
1982
9
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. ( 985824 )
1976

Variations for Prolactin Producing Pituitary Tumor

Expression for Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for Prolactin Producing Pituitary Tumor

Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 NGF NTRK1 PRL TP53
2 12.03 CALCA NGF NTRK1
4
Show member pathways
11.31 NGF NTRK1 TP53
5 11.22 NTRK1 TP53
6
Show member pathways
11.15 NGF NTRK1
7
Show member pathways
9.66 NGF NTRK1

GO Terms for Prolactin Producing Pituitary Tumor

Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 CALCA DRD2 NGF NTRK1

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.77 DRD2 NTRK1 SST
2 regulation of signaling receptor activity GO:0010469 9.62 CALCA NGF PRL SST
3 response to nutrient levels GO:0031667 9.61 NTRK1 PRL
4 activation of MAPKK activity GO:0000186 9.6 NGF NTRK1
5 response to heat GO:0009408 9.58 CALCA SST
6 phosphatidylinositol-mediated signaling GO:0048015 9.58 NGF NTRK1
7 feeding behavior GO:0007631 9.57 CALCA DRD2
8 response to nicotine GO:0035094 9.56 DRD2 NTRK1
9 modulation of chemical synaptic transmission GO:0050804 9.55 DRD2 NGF
10 pigmentation GO:0043473 9.54 DRD2 TYRP1
11 cellular response to nerve growth factor stimulus GO:1990090 9.52 CALCA NTRK1
12 regulation of heart rate GO:0002027 9.51 CALCA DRD2
13 negative regulation of blood pressure GO:0045776 9.49 CALCA DRD2
14 response to axon injury GO:0048678 9.48 DRD2 NTRK1
15 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.46 PRL TP53
16 positive regulation of Ras protein signal transduction GO:0046579 9.43 NGF NTRK1
17 neurotrophin TRK receptor signaling pathway GO:0048011 9.4 NGF NTRK1
18 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.37 CALCA NTRK1
19 G-protein coupled receptor internalization GO:0002031 9.26 CALCA DRD2
20 cell-cell signaling GO:0007267 9.26 CALCA DRD2 NGF SST
21 nerve growth factor signaling pathway GO:0038180 9.16 NGF NTRK1
22 negative regulation of cell proliferation GO:0008285 9.02 DRD2 NGF NTRK1 SST TP53

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA PRL SST

Sources for Prolactin Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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