MCID: PRL010
MIFTS: 32

Prolactin Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

MalaCards integrated aliases for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 12 15
Prolactin-Producing Pituitary Gland Carcinoma 12 17 70
Prolactin-Producing Pituitary Tumor 54 70
Malignant Prolactin Producing Neoplasm of Pituitary Gland 12
Prolactin Secreting Tumour of Pituitary 12
Prolactin Secreting Tumor of Pituitary 12
Prolactin Producing Pituitary Tumour 12
Malignant Prolactinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5396
NCIt 50 C5962 C7910
UMLS 70 C0278863 C1334614

Summaries for Prolactin Producing Pituitary Tumor

Disease Ontology : 12 A pituitary carcinoma that is located in the anterior lobe of the pituitary gland that produces prolactin.

MalaCards based summary : Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary gland carcinoma, is related to pituitary tumors and galactorrhea. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Relaxin signaling pathway. The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include anterior lobe of the pituitary gland and pituitary, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Prolactin Producing Pituitary Tumor

Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 30.6 SSTR5 PRL POMC
2 galactorrhea 30.5 PRL DRD2
3 pituitary adenoma, prolactin-secreting 30.2 SSTR5 PRL POMC DRD2
4 amenorrhea 30.1 PRL POMC
5 diabetes insipidus 30.0 PRL POMC
6 pituitary hormone deficiency, combined, 2 30.0 PRL POMC GHRH
7 hyperprolactinemia 29.7 PRL POMC GHRH DRD2
8 pituitary adenoma 29.4 SSTR5 PRL POMC GHRH DRD2
9 pituitary carcinoma 29.2 PRL POMC MGMT GHRH
10 adenoma 29.1 SSTR5 PRL POMC MGMT GHRH
11 schizophreniform disorder 10.2 PRL DRD2
12 adenohypophysitis 10.2 PRL POMC
13 chromophobe adenoma 10.2 PRL POMC
14 ectopic cushing syndrome 10.2 PRL POMC
15 antisocial personality disorder 10.2 PRL DRD2
16 abducens nerve disease 10.2 PRL POMC
17 personality disorder 10.2 PRL DRD2
18 hypothyroidism, congenital, nongoitrous, 4 10.2 PRL POMC
19 peripartum cardiomyopathy 10.2 PRL DRD2
20 benign essential hypertension 10.2 PRL POMC
21 cranial nerve palsy 10.2 PRL POMC
22 pituitary apoplexy 10.2 PRL POMC
23 empty sella syndrome 10.2 PRL POMC
24 social phobia 10.2 PRL DRD2
25 van maldergem syndrome 1 10.2 PRL POMC
26 acth deficiency, isolated 10.2 PRL POMC
27 melancholia 10.2 PRL POMC
28 steroid inherited metabolic disorder 10.1 PRL POMC
29 lactocele 10.1 PRL GHRH
30 migraine without aura 10.1 PRL DRD2
31 diabetes insipidus, neurohypophyseal 10.1 PRL POMC
32 gigantism 10.1 PRL GHRH
33 borderline personality disorder 10.1 PRL DRD2
34 opioid abuse 10.1 POMC DRD2
35 phobic disorder 10.1 POMC DRD2
36 sebaceous gland disease 10.1 PRL POMC
37 cocaine abuse 10.1 PRL DRD2
38 sexual disorder 10.1 PRL POMC
39 opiate dependence 10.1 POMC DRD2
40 pseudohypoparathyroidism, type ia 10.1 PRL GHRH
41 postpartum depression 10.1 PRL POMC
42 central nervous system benign neoplasm 10.1 PRL POMC
43 adrenal gland disease 10.1 PRL POMC
44 goiter 10.1
45 hyperthyroidism 10.1
46 partial third-nerve palsy 10.1 PRL MGMT
47 gynecomastia 10.1 PRL POMC
48 fibrous dysplasia 10.1 PRL GHRH
49 disorder of sexual development 10.0 PRL POMC
50 impotence 10.0 PRL POMC

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to Prolactin Producing Pituitary Tumor

Symptoms & Phenotypes for Prolactin Producing Pituitary Tumor

MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 DRD2 GHRH MGMT POMC PRL SSTR5
2 homeostasis/metabolism MP:0005376 9.5 DRD2 GHRH GPR4 MGMT POMC PRL
3 neoplasm MP:0002006 9.02 DRD2 GPR4 MGMT POMC PRL

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
2
Octreotide Approved, Investigational Phase 1 83150-76-9 6400441 383414
3
Phenylalanine Approved, Investigational, Nutraceutical Phase 1 63-91-2 6140
4 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
5 Radiopharmaceuticals Phase 1
6 Edotreotide Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Antineoplastons A10 and AS2-1 in Patients With Metastatic or Incurable Neuroendocrine Tumors Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 An Open Label, Multicenter, Phase II Study Evaluating the Safety and Efficacy of Temozolomide Treatment in Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
4 A Phase I Study of [111In-DTPA-D-Phe]-Octreotide in Patients With Refractory Malignancies Expressing Somatostatin Receptors Terminated NCT00002947 Phase 1
5 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

Anatomical Context for Prolactin Producing Pituitary Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Prolactin Producing Pituitary Tumor:

19
Anterior Lobe Of The Pituitary Gland

MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

40
Pituitary

Publications for Prolactin Producing Pituitary Tumor

Articles related to Prolactin Producing Pituitary Tumor:

(show all 13)
# Title Authors PMID Year
1
[Prolactin producing pituitary tumor]. 54 61
11808216 2001
2
Multiple Endocrine Tumors Associated with Germline MAX Mutations: Multiple Endocrine Neoplasia Type 5? 61
33367756 2021
3
Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells. 61
31956173 2020
4
Pituitary apoplexy caused by luteinizing hormone-releasing hormone in prolactin-producing adenoma. 61
11518116 2001
5
Prolactin producing pituitary tumors in postmenopausal patients--"infrequent or infrequently recognized". 54
9531902 1998
6
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. 61
7714616 1995
7
Plasma calcitonin, IGF-I levels and vertebral bone mineral density in hyperprolactinemic women during bromocriptine treatment. 61
8317189 1993
8
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. 61
2570719 1989
9
[Follow-up of a pediatric prolactin-producing hypophyseal tumor]. 61
3702892 1986
10
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. 61
7098479 1982
11
[Bromocriptine and a prolactin-producing pituitary tumor]. 61
7336060 1981
12
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. 61
985824 1976
13
Pulsatile gonadotropin output in menstrual dysfunction. 61
175324 1976

Variations for Prolactin Producing Pituitary Tumor

Expression for Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for Prolactin Producing Pituitary Tumor

GO Terms for Prolactin Producing Pituitary Tumor

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.8 SSTR5 PRL POMC GPR4 DRD2
2 G protein-coupled receptor signaling pathway GO:0007186 9.55 SSTR5 POMC GPR4 GHRH DRD2
3 negative regulation of cell death GO:0060548 9.43 MGMT DRD2
4 positive regulation of cytokinesis GO:0032467 9.37 SSTR5 DRD2
5 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.32 GPR4 DRD2
6 positive regulation of multicellular organism growth GO:0040018 9.26 GHRH DRD2
7 positive regulation of growth hormone secretion GO:0060124 8.96 GHRH DRD2
8 adenohypophysis development GO:0021984 8.62 GHRH DRD2

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 PRL POMC GHRH

Sources for Prolactin Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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