MCID: PRL010
MIFTS: 41

Prolactin Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Prolactin Producing Pituitary Tumor

MalaCards integrated aliases for Prolactin Producing Pituitary Tumor:

Name: Prolactin Producing Pituitary Tumor 12 15
Prolactin-Producing Pituitary Gland Carcinoma 12 73
Prolactin-Producing Pituitary Tumor 55 73
Malignant Prolactin Producing Neoplasm of Pituitary Gland 12
Prolactin Secreting Tumor of Pituitary 12
Malignant Prolactinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5396
NCIt 50 C5962 C7910

Summaries for Prolactin Producing Pituitary Tumor

Disease Ontology : 12 A pituitary carcinoma that is located in the anterior lobe of the pituitary gland that produces prolactin.

MalaCards based summary : Prolactin Producing Pituitary Tumor, also known as prolactin-producing pituitary gland carcinoma, is related to pituitary tumors and galactorrhea. An important gene associated with Prolactin Producing Pituitary Tumor is PRL (Prolactin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Neuroscience. The drugs Hormones and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, cortex and lung, and related phenotypes are behavior/neurological and integument

Related Diseases for Prolactin Producing Pituitary Tumor

Diseases related to Prolactin Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 30.8 PRL SST
2 galactorrhea 30.2 DRD2 PRL
3 hyperprolactinemia 30.0 DRD2 PRL SST
4 schizophreniform disorder 10.2 DRD2 PRL
5 social phobia 10.2 DRD2 PRL
6 peripartum cardiomyopathy 10.2 DRD2 PRL
7 pituitary infarct 10.1 PRL SST
8 chiasmal syndrome 10.1 PRL SST
9 pituitary carcinoma 10.1 PRL SST
10 migraine without aura 10.1 DRD2 PRL
11 nelson syndrome 10.1 PRL SST
12 hyperpituitarism 10.1 PRL SST
13 growth hormone secreting pituitary adenoma 10.1 PRL SST
14 tsh producing pituitary tumor 10.1 PRL SST
15 spinocerebellar degeneration 10.1 PRL SST
16 cocaine abuse 10.1 DRD2 PRL
17 pituitary adenoma 1, multiple types 10.1 PRL SST
18 personality disorder 10.1 DRD2 PRL
19 adrenal cortex disease 10.1 PRL SST
20 askin's tumor 10.1 NGF NTRK1
21 pituitary-dependent cushing's disease 10.1 PRL SST
22 conjunctival nevus 10.1 NGF NTRK1
23 neuropathy, hereditary sensory and autonomic, type v 10.1 NGF NTRK1
24 mccune-albright syndrome 10.1 PRL SST
25 granulosa cell tumor of the ovary 10.1 PRL TP53
26 sweat gland disease 10.1 NGF NTRK1
27 cortical thymoma 10.1 NGF SST
28 chromophobe adenoma 10.1 PRL TP53
29 anhidrosis 10.1 NGF NTRK1
30 opiate dependence 10.1 DRD2 NGF
31 adenomyosis 10.1 NGF PRL
32 ocular cicatricial pemphigoid 10.1 NGF NTRK1
33 pituitary gland disease 10.1 PRL SST
34 cerebral cavernous malformations 2 10.0 NGF NTRK1
35 cerebral neuroblastoma 10.0 NGF TP53
36 ependymoblastoma 10.0 NGF TP53
37 hereditary sensory neuropathy 10.0 NGF NTRK1
38 meningeal melanomatosis 10.0 NGF TP53
39 cluster headache 10.0 CALCA PRL
40 ovarian cystic teratoma 10.0 CALCA PRL
41 functioning pituitary adenoma 10.0 DRD2 PRL SST
42 pituitary adenoma, prolactin-secreting 10.0 DRD2 PRL SST
43 gastrointestinal system benign neoplasm 10.0 SST TP53
44 goiter 10.0
45 amenorrhea 10.0
46 hyperthyroidism 10.0
47 wdha syndrome 10.0 CALCA SST
48 diabetic neuropathy 10.0 NGF NTRK1
49 algoneurodystrophy 10.0 CALCA NGF
50 pancreatic somatostatinoma 10.0 CALCA SST

Graphical network of the top 20 diseases related to Prolactin Producing Pituitary Tumor:



Diseases related to Prolactin Producing Pituitary Tumor

Symptoms & Phenotypes for Prolactin Producing Pituitary Tumor

MGI Mouse Phenotypes related to Prolactin Producing Pituitary Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 DRD2 NGF NTRK1 PRL SST TP53
2 integument MP:0010771 9.85 DRD2 NGF NTRK1 PRL TP53 TYRP1
3 nervous system MP:0003631 9.8 DRD2 NGF NTRK1 PRL SST TP53
4 neoplasm MP:0002006 9.62 DRD2 PRL TP53 TYRP1
5 no phenotypic analysis MP:0003012 9.55 DRD2 NGF NTRK1 SST TP53
6 normal MP:0002873 9.35 DRD2 NGF NTRK1 SST TP53
7 pigmentation MP:0001186 8.92 DRD2 NTRK1 TP53 TYRP1

Drugs & Therapeutics for Prolactin Producing Pituitary Tumor

Drugs for Prolactin Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
3
Somatostatin Approved, Investigational Phase 1 51110-01-1, 38916-34-6 53481605
4 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
5 Radiopharmaceuticals Phase 1
6 Antineoplastic Agents, Hormonal Phase 1
7 Edotreotide Phase 1
8 Gastrointestinal Agents Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
10 Hormone Antagonists Phase 1
11 phenylalanine Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1
5 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Prolactin Producing Pituitary Tumor

Genetic Tests for Prolactin Producing Pituitary Tumor

Anatomical Context for Prolactin Producing Pituitary Tumor

MalaCards organs/tissues related to Prolactin Producing Pituitary Tumor:

41
Pituitary, Cortex, Lung, Ovary, Pancreas, Thyroid, Adrenal Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Prolactin Producing Pituitary Tumor:

19
The Anterior Lobe Of The Pituitary Gl

Publications for Prolactin Producing Pituitary Tumor

Articles related to Prolactin Producing Pituitary Tumor:

# Title Authors Year
1
[Prolactin producing pituitary tumor]. ( 11808216 )
2001
2
Prolactin-producing pituitary tumor: resistance to dopamine agonist therapy. Case report. ( 7714616 )
1995
3
Reduction in the size of prolactin-producing pituitary tumor after Cabergoline administration. ( 2570719 )
1989
4
Variations in the levels of estrogen receptors in prolactin producing pituitary tumor cells. ( 7098479 )
1982
5
Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. ( 985824 )
1976

Variations for Prolactin Producing Pituitary Tumor

Expression for Prolactin Producing Pituitary Tumor

Search GEO for disease gene expression data for Prolactin Producing Pituitary Tumor.

Pathways for Prolactin Producing Pituitary Tumor

Pathways related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 NGF NTRK1 PRL TP53
2 12.08 CALCA NGF NTRK1
3
Show member pathways
11.79 NGF NTRK1 TP53
5
Show member pathways
11.51 NGF NTRK1 TP53
6
Show member pathways
11.22 NGF NTRK1
7 10.45 DRD2 NGF NTRK1
8
Show member pathways
10 NGF NTRK1

GO Terms for Prolactin Producing Pituitary Tumor

Cellular components related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 CALCA DRD2 NGF NTRK1

Biological processes related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.62 CALCA NGF PRL SST
2 response to nutrient levels GO:0031667 9.58 NTRK1 PRL
3 response to heat GO:0009408 9.58 CALCA SST
4 activation of MAPKK activity GO:0000186 9.57 NGF NTRK1
5 phosphatidylinositol-mediated signaling GO:0048015 9.56 NGF NTRK1
6 response to nicotine GO:0035094 9.55 DRD2 NTRK1
7 pigmentation GO:0043473 9.54 DRD2 TYRP1
8 cellular response to nerve growth factor stimulus GO:1990090 9.52 CALCA NTRK1
9 feeding behavior GO:0007631 9.51 CALCA DRD2
10 negative regulation of blood pressure GO:0045776 9.49 CALCA DRD2
11 response to axon injury GO:0048678 9.48 DRD2 NTRK1
12 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.46 PRL TP53
13 neurotrophin TRK receptor signaling pathway GO:0048011 9.43 NGF NTRK1
14 positive regulation of Ras protein signal transduction GO:0046579 9.4 NGF NTRK1
15 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.37 CALCA NTRK1
16 G protein-coupled receptor internalization GO:0002031 9.26 CALCA DRD2
17 response to drug GO:0042493 9.26 DRD2 NTRK1 PRL SST
18 nerve growth factor signaling pathway GO:0038180 9.16 NGF NTRK1
19 negative regulation of cell proliferation GO:0008285 9.02 DRD2 NGF NTRK1 SST TP53

Molecular functions related to Prolactin Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA PRL SST

Sources for Prolactin Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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