MCID: PRL015
MIFTS: 21

Prolapse of Female Genital Organ

Categories: Reproductive diseases

Aliases & Classifications for Prolapse of Female Genital Organ

MalaCards integrated aliases for Prolapse of Female Genital Organ:

Name: Prolapse of Female Genital Organ 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1284
ICD9CM 35 618.8 618.89
UMLS 73 C0029801

Summaries for Prolapse of Female Genital Organ

Disease Ontology : 12 A female reproductive system disease that is characteried by the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening.

MalaCards based summary : Prolapse of Female Genital Organ is related to pelvic muscle wasting and enterocele. An important gene associated with Prolapse of Female Genital Organ is BRD2 (Bromodomain Containing 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Thromboxane A2 receptor signaling. The drugs Baclofen and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include uterus and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Prolapse of Female Genital Organ

Diseases related to Prolapse of Female Genital Organ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 pelvic muscle wasting 32.0 HCK LMNA
2 enterocele 30.0 ARHGEF1 BRD2 CD9 CMKLR1 COL1A1 PPAN
3 prolapse of urethra 11.3
4 paralytic poliomyelitis 10.2 ARHGEF1 PVR
5 poliomyelitis 10.2 ARHGEF1 PVR
6 facial hemiatrophy 10.1 ARHGEF1 SLC4A1
7 de quervain disease 10.0 HCK SLC4A1
8 syringomyelia 10.0 COL1A1 PVR
9 splenic artery aneurysm 10.0 HCK SLC4A1
10 peripheral osteosarcoma 9.9 SPARC WDFY2
11 osteogenesis imperfecta, type iv 9.9 COL1A1 SPARC

Graphical network of the top 20 diseases related to Prolapse of Female Genital Organ:



Diseases related to Prolapse of Female Genital Organ

Symptoms & Phenotypes for Prolapse of Female Genital Organ

MGI Mouse Phenotypes related to Prolapse of Female Genital Organ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 ARHGEF1 BRD2 CD9 CMKLR1 COL1A1 HCK
2 immune system MP:0005387 9.61 ARHGEF1 BRD2 CD9 CMKLR1 COL1A1 HCK
3 respiratory system MP:0005388 9.1 BRD2 CD9 CMKLR1 COL1A1 HCK LMNA

Drugs & Therapeutics for Prolapse of Female Genital Organ

Drugs for Prolapse of Female Genital Organ (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Baclofen Approved Phase 4 1134-47-0 2284
2 Anesthetics Not Applicable
3 Mitogens

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 National,Multicentric Randomised Study of the Correction of Genital Prolapse With Fascial Repair or Mesh-Prolift Unknown status NCT00771225 Phase 4
2 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
3 Vaginal Estriol Before and Vaginal Surgery for Prolapse Unknown status NCT02906111 Phase 4 estriol
4 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
5 Dysfunctional Voiding and Lower Urinary Tract Symptoms With Baclofen Terminated NCT01003249 Phase 4 Baclofen;Placebo
6 Pelvic Organ Prolapse Repair Plus Mini-Sling Versus Pelvic Organ Prolapse Repair Alone Completed NCT01384084 Phase 3
7 Prenatal Pelvic Floor Prevention (3PN) Completed NCT00551551 Phase 3
8 Surgical Correction of Pelvic Organ Prolapse Completed NCT01182090 Phase 3
9 Mesh Repair of Anterior Vaginal Wall Prolapse Completed NCT00420225 Phase 3
10 Mechanism of Incontinence Before and After Genital Prolapse Surgery Unknown status NCT02050568
11 Conservative Management of Symptomatic Pelvic Organ Prolapse Using Vaginal Pessaries: Generation of a Standardized Management Protocol Unknown status NCT02113969 Not Applicable
12 Long Term Outcomes Following Total Laparoscopic Hysterectomy and Laparoscopic Supracervical Hysterectomy Unknown status NCT01289314 Not Applicable
13 Dynamic MRI of the Behaviour of Female Pelvic Floor Completed NCT00747370 Early Phase 1
14 Comparison of Single Versus Multicenter Outcomes for Pelvic Organ Prolapse Repair Using a Mesh-capturing Device Completed NCT03077490
15 Single Incision Transvaginal Mesh in Treatment of Posterior Vaginal Wall Prolapse Completed NCT02092623 Not Applicable
16 Observational Data Collection of Surgical Outcomes in the Treatment of Vaginal Prolapse With AMS Products Completed NCT00388947
17 Vaginal Microbiota as a Decisive Factor in Vaginal Prosthetic Surgery Completed NCT02890498
18 Validation of a New Sexuality Questionnaire for Patients With Urinary Incontinence or Pelvic Organ Prolapse Completed NCT01548989
19 Validation of a French Version of the PISQ-R Completed NCT01548976
20 Prosthetic Pelvic Organ Prolapse Repair Completed NCT01637441 Not Applicable
21 Comparison of the Result of TVT Performed at the Time of Prolapse Surgery or 3 Months After Completed NCT00308009 Not Applicable
22 Pessary Satisfaction Criteria for Urogenital Prolapse Recruiting NCT03615872
23 Bilateral Sacrospinous Colposuspension (BSC) in the Female Genital Prolapse With Urinary Urge Symptomatology Recruiting NCT03640364
24 Laparoscopic Sacrocolpexy Versus Lateral Suspension Recruiting NCT03582852 Not Applicable
25 A Novel Assay for Predicting Surgical Outcomes in Pelvic Organ Prolapse Recruiting NCT03534830
26 Comparison of Anterior Prosthetic Vaginal Sacrospinofixation With Laparoscopic Promontofixation for the Treatment of Anterior and Apical Genitourinary Prolapse Recruiting NCT03200327 Not Applicable
27 Per-operative Ultrasonographic Assessement of the Placement of the Mesh in Laparoscopic Sacral Colpo/Hysteropexy Recruiting NCT03410303 Not Applicable
28 The Change in Vaginal Axis on MRI After Uterus Preserving Laparoscopic Lateral Mesh Suspension Recruiting NCT03772015
29 Materiovigilance After Urinary Incontinence or Prolapse Surgery Recruiting NCT03052985
30 Assessment and Comparison of Biomarkers in Women With Symptoms of Overactive Bladder (OAB) and Pelvic Organ Prolapse (POP) Recruiting NCT03516292
31 Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor Recruiting NCT02484820 Not Applicable
32 Ambulatory Prolapse Surgery Active, not recruiting NCT02585544 Not Applicable
33 Efficacy of IFABONDTM Synthetic Glue for Fixation of Implanted Material in Laparoscopic Sacrocolpopexy: a Prospective Multicenter Study Active, not recruiting NCT02011373 Not Applicable
34 Advanced Genital Prolapse Surgery With and Without Mid Urethral Sling to Prevent Stress Urinary Incontinence Enrolling by invitation NCT02578056 Not Applicable
35 The Effect of Pessary Post Vaginal Prolapse Repair, for One Month, to Reduce the Recurrence Rate of Prolapse Not yet recruiting NCT03056586 Not Applicable
36 Observing Pelvic Organ Prolapse Symptoms And Treatment Outcomes Terminated NCT00784602
37 Intraoperative Goal-directed Fluid Management Withdrawn NCT00554944 Not Applicable

Search NIH Clinical Center for Prolapse of Female Genital Organ

Genetic Tests for Prolapse of Female Genital Organ

Anatomical Context for Prolapse of Female Genital Organ

MalaCards organs/tissues related to Prolapse of Female Genital Organ:

41
Uterus, Bone

Publications for Prolapse of Female Genital Organ

Variations for Prolapse of Female Genital Organ

Expression for Prolapse of Female Genital Organ

Search GEO for disease gene expression data for Prolapse of Female Genital Organ.

Pathways for Prolapse of Female Genital Organ

Pathways related to Prolapse of Female Genital Organ according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 ARHGEF1 LMNA PVR RAB4A
2 10.61 ARHGEF1 HCK

GO Terms for Prolapse of Female Genital Organ

Cellular components related to Prolapse of Female Genital Organ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 9.13 RAB4A SPARC WDFY2
2 platelet alpha granule membrane GO:0031092 8.62 CD9 SPARC

Biological processes related to Prolapse of Female Genital Organ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of fat cell differentiation GO:0045600 9.16 CMKLR1 WDFY2
2 response to cAMP GO:0051591 8.96 COL1A1 SPARC
3 protein localization to nucleus GO:0034504 8.62 COL1A1 LMNA

Molecular functions related to Prolapse of Female Genital Organ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.4 ARHGEF1 BRD2 CD9 CMKLR1 COL1A1 HCK

Sources for Prolapse of Female Genital Organ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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