MCID: PRL004
MIFTS: 28

Prolapse of Urethra

Categories: Reproductive diseases

Aliases & Classifications for Prolapse of Urethra

MalaCards integrated aliases for Prolapse of Urethra:

Name: Prolapse of Urethra 12 15 71
Urethrocele 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12369
ICD9CM 34 618.03
SNOMED-CT 67 12068006
ICD10 32 N81.0
UMLS 71 C0238502

Summaries for Prolapse of Urethra

Disease Ontology : 12 A prolapse of female genital organ that is characterized by the descent of the urethra from the normal anatomic location toward or through the vaginal opening.

MalaCards based summary : Prolapse of Urethra, also known as urethrocele, is related to intravascular fasciitis and polycystic kidney disease 4. An important gene associated with Prolapse of Urethra is MIIP (Migration And Invasion Inhibitory Protein), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. Affiliated tissues include skin, and related phenotypes are cardiovascular system and immune system

Related Diseases for Prolapse of Urethra

Diseases related to Prolapse of Urethra via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 intravascular fasciitis 10.3 ELN CALD1
2 polycystic kidney disease 4 10.3 ELN ALB
3 immuno-osseous dysplasia 10.2 ELN ALB
4 diffuse peritoneal leiomyomatosis 10.2 GNRH1 CALD1
5 peritoneal benign neoplasm 10.2 GNRH1 CALD1
6 stress polycythemia 10.2 LDHA ALB
7 chronic actinic dermatitis 10.2 MMP9 ELN
8 cardiomyopathy, familial hypertrophic, 20 10.2 NEXN ELN ALB
9 urethral diverticulum 10.2
10 infiltrating angiolipoma 10.2 GNRH1 CALD1
11 senile ectropion 10.2 MMP9 ELN
12 bladder leiomyoma 10.1 GNRH1 CALD1
13 pulmonary emphysema 10.0 MMP9 ELN ALB
14 pneumothorax 10.0 MMP9 GNRH1 ELN
15 coronary aneurysm 10.0 MMP9 ALB
16 noma 9.9 CDC42 ALB
17 ureterocele 9.9
18 spinal cord injury 9.9
19 lymphangioleiomyomatosis 9.9 MMP9 GNRH1 ELN
20 villonodular synovitis 9.9 MMP9 CSF1
21 aarskog-scott syndrome 9.9 NEXN CTTN CDC42
22 microvascular complications of diabetes 1 9.9 MMP9 IGFBP2 ALB
23 heart aneurysm 9.9 MMP9 ALB
24 diffuse idiopathic skeletal hyperostosis 9.9 GAPDH EGF ALB
25 chronic ulcer of skin 9.9 MMP9 EGF ALB
26 aortic aneurysm, familial abdominal, 1 9.9 MMP9 ELN ALB
27 hypotrichosis 1 9.8 GAPDH EGF ALB
28 endosteal hyperostosis, autosomal dominant 9.8 IGFBP2 EGF CSF1
29 pelizaeus-merzbacher disease 9.8 GAPDH EGF ALB
30 cerebral degeneration 9.8 GAPDH EGF ALB
31 shigellosis 9.8 CTTN CDC42 ALB
32 metachromatic leukodystrophy 9.8 GAPDH EGF ALB
33 hydronephrosis 9.7 MMP9 EGF ALB
34 tongue disease 9.7 MMP9 GAPDH EGF
35 distal arthrogryposis 9.7 GAPDH ELN EGF ALB
36 open-angle glaucoma 9.7 MMP9 GAPDH ELN ALB
37 ovarian disease 9.7 IGFBP2 GNRH1 GAPDH ALB
38 bone inflammation disease 9.7 MMP9 GAPDH ALB
39 amelogenesis imperfecta, type ig 9.6 GNRH1 GAPDH EGF ALB
40 x-linked recessive disease 9.6 GAPDH CDC42 ALB
41 pulmonary fibrosis, idiopathic 9.5 MMP9 GAPDH ELN EGF ALB
42 macular degeneration, age-related, 1 9.4 MMP9 GAPDH ELN EGF ALB
43 polycystic kidney disease 9.4 MMP9 GAPDH EGF CTTN ALB
44 amelogenesis imperfecta 9.4 MMP9 GNRH1 GAPDH EGF ALB
45 rasopathy 9.3 GAPDH ELN EGF CDC42 ALB
46 peripheral nervous system disease 9.2 MMP9 GAPDH EGF ALB
47 dilated cardiomyopathy 9.2 NEXN MMP9 ITGA5 GAPDH ELN ALB
48 osteoporosis 9.1 MMP9 IGFBP2 GNRH1 EGF CSF1 ALB
49 renal cell carcinoma, nonpapillary 9.1 TWSG1 MMP9 LDHA GAPDH EGF CSF1
50 amyotrophic lateral sclerosis 1 8.8 IGFBP2 GAPDH CTTN CSF1 CDC42 ALB

Graphical network of the top 20 diseases related to Prolapse of Urethra:



Diseases related to Prolapse of Urethra

Symptoms & Phenotypes for Prolapse of Urethra

MGI Mouse Phenotypes related to Prolapse of Urethra:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ALB CSF1 CTTN GAPDH IGFBP2 ITGA5
2 immune system MP:0005387 9.93 ALB CSF1 CTTN EGF GNRH1 HDAC6
3 normal MP:0002873 9.56 ALB EGF GNRH1 HDAC6 IGFBP2 ITGA5
4 respiratory system MP:0005388 9.17 CSF1 CTTN LDHA MCU MMP9 PAK1

Drugs & Therapeutics for Prolapse of Urethra

Search Clinical Trials , NIH Clinical Center for Prolapse of Urethra

Genetic Tests for Prolapse of Urethra

Anatomical Context for Prolapse of Urethra

MalaCards organs/tissues related to Prolapse of Urethra:

40
Skin

Publications for Prolapse of Urethra

Articles related to Prolapse of Urethra:

(show all 46)
# Title Authors PMID Year
1
Laparoscopic Pectopexy with Burch Colposuspension for Pelvic Prolapse Associated with Stress Urinary Incontinence. 61
31683027 2020
2
Congenital urethrocele in children. A case report. 61
33137671 2020
3
Urethro-vaginal reflux during micturition: An underestimated cause of urinary incontinence in adult women. 61
31436352 2019
4
Cesarean section after laparoscopic hysterosacropexy with Richardson's lateral repair and Burch operation-Case report. 61
31174002 2019
5
Liposomal bupivacaine decreases pain following retropubic sling placement: a randomized placebo-controlled trial. 61
28694151 2017
6
Late surgical correction of hypospadias increases the risk of complications: a series of 501 consecutive patients. 61
28083998 2017
7
Management of Proximal Hypospadias with 2-Stage Repair: 20-Year Experience. 61
25963188 2015
8
[Modified Mathieu urethroplasty for failed hypospadias repair]. 61
24218948 2013
9
Original Koyanagi urethroplasty versus modified Hayashi technique: outcome in 57 patients. 61
19457720 2009
10
Outcome of severe hypospadias repair using three different techniques. 61
19201261 2009
11
Observations on the function of the female urethra: III: An overview with special reference to the relation between urethral hypermobility and urethral incompetence. 61
14694452 2004
12
Four-corner colposuspension: clinical and functional results. 61
12851754 2003
13
Observations on the function of the female urethra: I: relation between maximum urethral closure pressure at rest and urethral hypermobility. 61
14595607 2003
14
Dynamic half Fourier acquisition, single shot turbo spin-echo magnetic resonance imaging for evaluating the female pelvis. 61
11025716 2000
15
[Posterior genital prolapse following the Burch method of colposuspension]. 61
10582398 1999
16
[Congenital urethrocele in children. A case report]. 61
10352818 1999
17
A one-stage dorsal free-graft urethroplasty for bulbar urethral strictures. 61
9014721 1996
18
[Incidence of pelvic-genital static disorders in patients with urinary incontinence]. 61
8925975 1996
19
Voiding cystourethrography in female stress incontinence. 61
8623628 1996
20
Dorsal free graft urethroplasty. 61
7490808 1996
21
Recurrent pelvic support defects after sacrospinous ligament fixation for vaginal vault prolapse. 61
7719548 1995
22
[Stenosis of the male urethra: single-stage canal reconstruction using a mobile, vascular, pedicled skin graft. 245 personal cases]. 61
8130803 1993
23
[Urethrocele in males]. 61
8253886 1993
24
Retrospective analysis of 711 patients operated on for pelvic relaxation in 1983-1989. 61
7901057 1993
25
[Urethrocele in males]. 61
8163849 1993
26
[Urethroplasty for repairing recurrent urethrocele and loss of urethral substance: apropos of 41 cases]. 61
1509271 1992
27
Urethroplasty of recurrent urethrocele: study of 41 cases. 61
1414710 1992
28
[Congenital urethrocele in man. Apropos of 10 personal cases]. 61
2113789 1990
29
[Female urethrocele. Difficult diagnosis and therapy. Apropos of 10 cases]. 61
2742341 1989
30
[Subjective and objective improvement of urinary incontinence in females following vaginal and abdominal incontinence operations]. 61
3758635 1986
31
Incontinence following transurethral resection of the bladder neck in the female. 61
7470800 1981
32
[A case of urethrocele (radiographic image)]. 61
443877 1979
33
Our surgical approach towards the treatment of urethrocele and urethral fistula. 61
104265 1978
34
Skene's duct cyst in a newborn: case report and review of the literature. 61
839610 1977
35
[Apropos of a case of urethrocele]. 61
5662098 1968
36
[A rare case of congenital urethrocele]. 61
5874557 1965
37
[URETHROCELE AND SUB-URETHRAL CYSTS IN WOMEN. CLINICAL AND THERAPEUTIC REMARKS APROPOS OF 16 CASES]. 61
14213246 1964
38
[A case of congenital diverticulum of the anterior urethra (urethrocele, Causa Raspall)]. 61
13927500 1963
39
Cystocele, urethrocele, rectocele and uterine prolapse in women of childbearing age report of a case. 61
14403009 1960
40
[Urethrocele and diverticulum of the female urethra]. 61
13836378 1959
41
[Diverticulum and urethrocele of the female urethra]. 61
13676727 1959
42
[Urethrocele, giant calculus, and urethrovaginal fistula; surgical therapy]. 61
13137579 1953
43
Unusual examples of urethrocele and ureterocele; operative cure. 61
18151891 1949
44
The surgical anatomy of cystocele and urethrocele with special reference to the pubocervical fascia. 61
18120506 1948
45
Prolapse of Urethra in a Child. 61
19992886 1944
46
A Case of Urethrocele. 61
29613065 1885

Variations for Prolapse of Urethra

Expression for Prolapse of Urethra

Search GEO for disease gene expression data for Prolapse of Urethra.

Pathways for Prolapse of Urethra

Pathways related to Prolapse of Urethra according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 PAK1 MMP9 ITGA5 GNRH1 ELN EGF
2
Show member pathways
12.83 ITGA5 HDAC6 GNRH1 ELN EGF CDC42
3
Show member pathways
12.17 PAK1 ITGA5 GNRH1 EGF CDC42
4 12.04 PAK1 ITGA5 CTTN CDC42 CALD1
5 11.92 PAK1 ITGA5 CTTN CDC42
6 11.75 LDHA GAPDH EGF
7 11.67 PAK1 MMP9 ITGA5 CTTN CDC42
8 11.59 MMP9 LDHA GAPDH
9 11.56 ITGA5 CTTN CDC42
10 11.41 MMP9 ELN EGF
11 11.34 PAK1 CTTN CDC42
12
Show member pathways
11.15 PAK1 MMP9 CDC42
13 10.73 LDHA GAPDH
14 10.07 PAK1 ITGA5 GNRH1 ELN EGF CSF1

GO Terms for Prolapse of Urethra

Cellular components related to Prolapse of Urethra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.35 PAK1 HDAC6 GNRH1 CTTN CDC42
2 ruffle GO:0001726 9.33 PAK1 ITGA5 CTTN
3 focal adhesion GO:0005925 9.02 PAK1 NEXN ITGA5 CTTN CDC42

Biological processes related to Prolapse of Urethra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.43 ITGA5 IGFBP2 GNRH1
2 positive regulation of cell migration GO:0030335 9.35 PAK1 MMP9 ITGA5 EGF CSF1
3 ephrin receptor signaling pathway GO:0048013 9.33 PAK1 MMP9 CDC42
4 regulation of autophagy of mitochondrion GO:1903146 9.32 HDAC6 CTTN
5 macrophage differentiation GO:0030225 8.8 MMP9 CSF1 CDC42

Molecular functions related to Prolapse of Urethra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TWSG1 PAK1 NEXN MMP9 MIIP MCU
2 identical protein binding GO:0042802 9.23 PAK1 MMP9 MCU LDHA GAPDH CSF1

Sources for Prolapse of Urethra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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