MCID: PRL004
MIFTS: 27

Prolapse of Urethra

Categories: Reproductive diseases

Aliases & Classifications for Prolapse of Urethra

MalaCards integrated aliases for Prolapse of Urethra:

Name: Prolapse of Urethra 12 15 71
Urethrocele 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12369
ICD9CM 34 618.03
NCIt 49 C123256
SNOMED-CT 67 12068006
ICD10 32 N81.0
UMLS 71 C0238502

Summaries for Prolapse of Urethra

Disease Ontology : 12 A prolapse of female genital organ that is characterized by the descent of the urethra from the normal anatomic location toward or through the vaginal opening.

MalaCards based summary : Prolapse of Urethra, also known as urethrocele, is related to balanitis xerotica obliterans and urethral diverticulum. An important gene associated with Prolapse of Urethra is OMG (Oligodendrocyte Myelin Glycoprotein), and among its related pathways/superpathways are Cytoskeletal Signaling and Spinal Cord Injury. Affiliated tissues include heart, skin and bone, and related phenotypes are cardiovascular system and cellular

Related Diseases for Prolapse of Urethra

Diseases related to Prolapse of Urethra via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 10.4 MCU ELN
2 urethral diverticulum 10.4
3 intravascular fasciitis 10.4 ELN CALD1
4 ureteric orifice cancer 10.3 SLC7A1 ELN
5 meningitis and encephalitis 10.3 CAT ALB
6 immuno-osseous dysplasia 10.2 ELN ALB
7 polycystic kidney disease 4 10.2 ELN ALB
8 chronic actinic dermatitis 10.2 MMP9 ELN
9 ureterocele 10.2
10 spinal cord injury 10.2
11 cardiomyopathy, familial hypertrophic, 20 10.1 NEXN ELN ALB
12 senile ectropion 10.1 MMP9 ELN
13 endocardium disease 10.1 ELN CAT ALB
14 carbuncle 10.0 CAT ALB
15 noma 10.0 CDC42 ALB
16 aarskog-scott syndrome 10.0 NEXN CTTN CDC42
17 lymphangioleiomyomatosis 9.9 MMP9 IGFBP2 ELN
18 lymphoepithelioma-like thymic carcinoma 9.9 BRD4 ALB
19 heart aneurysm 9.9 MMP9 ALB
20 coronary aneurysm 9.9 MMP9 ALB
21 pulmonary emphysema 9.9 MMP9 ELN ALB
22 decubitus ulcer 9.8 SLC7A1 MMP9 ALB
23 gastroenteritis 9.8 MMP9 CAT ALB
24 bone squamous cell carcinoma 9.8 MMP9 CTTN
25 shigellosis 9.8 CTTN CDC42 ALB
26 parotitis 9.7 MMP9 ALB
27 hydronephrosis 9.7 MMP9 MCU ALB
28 bronchitis 9.7 MMP9 CAT ALB
29 inguinal hernia 9.5 TBX1 MMP9 ELN
30 atrial heart septal defect 9.5 TBX1 ELN ALB
31 tetralogy of fallot 9.3 TBX1 MMP9 ELN CAT
32 coronary artery anomaly 9.2 TBX1 MMP9 ELN ALB
33 patent foramen ovale 9.1 TBX1 ELN ALB
34 hypertension, essential 9.0 SLC7A1 POLB MMP9 ELN CAT BRD4
35 myeloma, multiple 9.0 MMP9 HDAC6 CSF1 BRD4 ALB

Graphical network of the top 20 diseases related to Prolapse of Urethra:



Diseases related to Prolapse of Urethra

Symptoms & Phenotypes for Prolapse of Urethra

MGI Mouse Phenotypes related to Prolapse of Urethra:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ALB CSF1 CTTN IGFBP2 MCU MMP9
2 cellular MP:0005384 10 ALB CAT CSF1 CTTN HDAC6 MCU
3 mortality/aging MP:0010768 9.97 ALB CAT CSF1 CTTN HDAC6 MCU
4 muscle MP:0005369 9.56 ALB CSF1 MCU MMP9 NEXN PDXP
5 respiratory system MP:0005388 9.17 CSF1 CTTN MCU MMP9 POLB TBX1

Drugs & Therapeutics for Prolapse of Urethra

Search Clinical Trials , NIH Clinical Center for Prolapse of Urethra

Genetic Tests for Prolapse of Urethra

Anatomical Context for Prolapse of Urethra

MalaCards organs/tissues related to Prolapse of Urethra:

40
Heart, Skin, Bone, Spinal Cord, Kidney

Publications for Prolapse of Urethra

Articles related to Prolapse of Urethra:

(show all 45)
# Title Authors PMID Year
1
Laparoscopic Pectopexy with Burch Colposuspension for Pelvic Prolapse Associated with Stress Urinary Incontinence. 61
31683027 2019
2
Urethro-vaginal reflux during micturition: An underestimated cause of urinary incontinence in adult women. 61
31436352 2019
3
Cesarean section after laparoscopic hysterosacropexy with Richardson's lateral repair and Burch operation-Case report. 61
31174002 2019
4
Liposomal bupivacaine decreases pain following retropubic sling placement: a randomized placebo-controlled trial. 61
28694151 2017
5
Late surgical correction of hypospadias increases the risk of complications: a series of 501 consecutive patients. 61
28083998 2017
6
Management of Proximal Hypospadias with 2-Stage Repair: 20-Year Experience. 61
25963188 2015
7
[Modified Mathieu urethroplasty for failed hypospadias repair]. 61
24218948 2013
8
Original Koyanagi urethroplasty versus modified Hayashi technique: outcome in 57 patients. 61
19457720 2009
9
Outcome of severe hypospadias repair using three different techniques. 61
19201261 2009
10
Observations on the function of the female urethra: III: An overview with special reference to the relation between urethral hypermobility and urethral incompetence. 61
14694452 2004
11
Four-corner colposuspension: clinical and functional results. 61
12851754 2003
12
Observations on the function of the female urethra: I: relation between maximum urethral closure pressure at rest and urethral hypermobility. 61
14595607 2003
13
Dynamic half Fourier acquisition, single shot turbo spin-echo magnetic resonance imaging for evaluating the female pelvis. 61
11025716 2000
14
[Posterior genital prolapse following the Burch method of colposuspension]. 61
10582398 1999
15
[Congenital urethrocele in children. A case report]. 61
10352818 1999
16
A one-stage dorsal free-graft urethroplasty for bulbar urethral strictures. 61
9014721 1996
17
[Incidence of pelvic-genital static disorders in patients with urinary incontinence]. 61
8925975 1996
18
Voiding cystourethrography in female stress incontinence. 61
8623628 1996
19
Dorsal free graft urethroplasty. 61
7490808 1996
20
Recurrent pelvic support defects after sacrospinous ligament fixation for vaginal vault prolapse. 61
7719548 1995
21
[Stenosis of the male urethra: single-stage canal reconstruction using a mobile, vascular, pedicled skin graft. 245 personal cases]. 61
8130803 1993
22
Retrospective analysis of 711 patients operated on for pelvic relaxation in 1983-1989. 61
7901057 1993
23
[Urethrocele in males]. 61
8253886 1993
24
[Urethrocele in males]. 61
8163849 1993
25
[Urethroplasty for repairing recurrent urethrocele and loss of urethral substance: apropos of 41 cases]. 61
1509271 1992
26
Urethroplasty of recurrent urethrocele: study of 41 cases. 61
1414710 1992
27
[Congenital urethrocele in man. Apropos of 10 personal cases]. 61
2113789 1990
28
[Female urethrocele. Difficult diagnosis and therapy. Apropos of 10 cases]. 61
2742341 1989
29
[Subjective and objective improvement of urinary incontinence in females following vaginal and abdominal incontinence operations]. 61
3758635 1986
30
Incontinence following transurethral resection of the bladder neck in the female. 61
7470800 1981
31
[A case of urethrocele (radiographic image)]. 61
443877 1979
32
Our surgical approach towards the treatment of urethrocele and urethral fistula. 61
104265 1978
33
Skene's duct cyst in a newborn: case report and review of the literature. 61
839610 1977
34
[Apropos of a case of urethrocele]. 61
5662098 1968
35
[A rare case of congenital urethrocele]. 61
5874557 1965
36
[URETHROCELE AND SUB-URETHRAL CYSTS IN WOMEN. CLINICAL AND THERAPEUTIC REMARKS APROPOS OF 16 CASES]. 61
14213246 1964
37
[A case of congenital diverticulum of the anterior urethra (urethrocele, Causa Raspall)]. 61
13927500 1963
38
Cystocele, urethrocele, rectocele and uterine prolapse in women of childbearing age report of a case. 61
14403009 1960
39
[Urethrocele and diverticulum of the female urethra]. 61
13836378 1959
40
[Diverticulum and urethrocele of the female urethra]. 61
13676727 1959
41
[Urethrocele, giant calculus, and urethrovaginal fistula; surgical therapy]. 61
13137579 1953
42
Unusual examples of urethrocele and ureterocele; operative cure. 61
18151891 1949
43
The surgical anatomy of cystocele and urethrocele with special reference to the pubocervical fascia. 61
18120506 1948
44
Prolapse of Urethra in a Child. 61
19992886 1944
45
A Case of Urethrocele. 61
29613065 1885

Variations for Prolapse of Urethra

Expression for Prolapse of Urethra

Search GEO for disease gene expression data for Prolapse of Urethra.

Pathways for Prolapse of Urethra

Pathways related to Prolapse of Urethra according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 PDXP CTTN CDC42 CALD1
2 11.21 OMG MMP9 CDC42

GO Terms for Prolapse of Urethra

Biological processes related to Prolapse of Urethra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendritic spine morphogenesis GO:0060997 9.32 HDAC6 CDC42
2 regulation of autophagy of mitochondrion GO:1903146 9.26 HDAC6 CTTN
3 response to hyperoxia GO:0055093 9.16 POLB CAT
4 salivary gland morphogenesis GO:0007435 8.96 TWSG1 POLB
5 macrophage differentiation GO:0030225 8.8 MMP9 CSF1 CDC42

Molecular functions related to Prolapse of Urethra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 TWSG1 TBX1 SLC7A1 POLB PDXP MMP9

Sources for Prolapse of Urethra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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