MCID: PRL003
MIFTS: 44

Proliferative Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Proliferative Glomerulonephritis

MalaCards integrated aliases for Proliferative Glomerulonephritis:

Name: Proliferative Glomerulonephritis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4778
NCIt 50 C35281
SNOMED-CT 68 441815006
UMLS 73 C0235618

Summaries for Proliferative Glomerulonephritis

MalaCards based summary : Proliferative Glomerulonephritis is related to acute proliferative glomerulonephritis and mesangial proliferative glomerulonephritis. An important gene associated with Proliferative Glomerulonephritis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Abatacept and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Proliferative Glomerulonephritis

Diseases in the Proliferative Glomerulonephritis family:

Acute Proliferative Glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 acute proliferative glomerulonephritis 34.5 CCL2 CD79A
2 mesangial proliferative glomerulonephritis 33.9 CCL2 CD79A IL6
3 glomerulonephritis 30.3 C3 CCL2 CD79A CFH CR1
4 anemia, autoimmune hemolytic 30.0 C3 CD79A
5 iga glomerulonephritis 30.0 CCL2 CD79A IL6
6 temporal arteritis 29.9 CCL2 IFNG IL6
7 membranoproliferative glomerulonephritis 29.8 C3 CD79A CFH
8 pulmonary disease, chronic obstructive 29.6 CCL2 CXCR3 IL6
9 brucellosis 29.5 IFNG IL4 IL6
10 psoriasis 28.1 CCL2 CXCR3 IFNG IL4 IL6
11 rheumatoid arthritis 28.0 CCL2 CD79A IFNG IL4 IL6
12 malaria 27.3 CCL2 CR1 CXCR3 IFNG IL4 IL6
13 systemic lupus erythematosus 26.5 C3 CCL2 CD79A CR1 CXCR3 IFNG
14 c1q deficiency 11.1
15 dense deposit disease 10.7 C3 CFH
16 retinal drusen 10.7 C3 CFH
17 t-cell/histiocyte rich large b cell lymphoma 10.6 CR1 IFNG
18 posterior uveitis 10.6 CFH IFNG
19 neuroschistosomiasis 10.6 CD79A IFNG
20 sporotrichosis 10.6 CD79A IFNG
21 enterocolitis 10.6 C3 CFH
22 complement factor i deficiency 10.6 C3 CR1
23 denture stomatitis 10.5 CCL2 IL6
24 strongyloidiasis 10.5 CD79A IFNG
25 chronic graft versus host disease 10.5 CD79A IFNG
26 clonorchiasis 10.5 CD79A IFNG
27 acute maxillary sinusitis 10.5 C3 CD79A
28 pleural tuberculosis 10.5 CCL2 IFNG
29 arteriolosclerosis 10.5 C3 CD79A
30 meconium aspiration syndrome 10.5 IFNG IL6
31 mycoplasmal pneumonia 10.5 IFNG IL4
32 relapsing polychondritis 10.5 IFNG IL6
33 orthostatic proteinuria 10.5 C3 CD79A
34 multicentric castleman disease 10.5 IFNG IL6
35 hypersensitivity vasculitis 10.5 C3 CD79A
36 stachybotrys chartarum 10.5 CCL2 IL6
37 hyperlucent lung 10.5 IFNG IL4
38 nonspecific interstitial pneumonia 10.5 CCL2 CXCR3 IFNG
39 baylisascariasis 10.4 IFNG IL4
40 penicillin allergy 10.4 IFNG IL4
41 pulmonary sarcoidosis 10.4 CCL2 CXCR3 IFNG
42 hand, foot and mouth disease 10.4 IFNG IL6
43 dendritic cell tumor 10.4 CR1 IFNG
44 atopic keratoconjunctivitis 10.4 IFNG IL4
45 chronic eosinophilic pneumonia 10.4 CXCR3 IL6
46 sarcoidosis 1 10.4 CCL2 CXCR3 IFNG
47 scleritis 10.4 CCL2 IL4
48 post-thrombotic syndrome 10.4 CCL2 IL6
49 septic arthritis 10.4 CXCR3 IFNG
50 eumycotic mycetoma 10.4 CR1 IFNG

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to Proliferative Glomerulonephritis

Symptoms & Phenotypes for Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 C3 IFNG IL4 CD79A CFH IL6
2 hematopoietic system MP:0005397 10.01 C3 IFNG IL4 CD79A CFH IL6
3 immune system MP:0005387 9.97 CCL2 IL4 CD79A CFH IL6 SIGLEC1
4 liver/biliary system MP:0005370 9.73 IFNG IL4 CD79A IL6 CTGF C3
5 normal MP:0002873 9.7 IL4 CD79A CFH CTGF CXCR3 C3
6 renal/urinary system MP:0005367 9.5 IL4 CD79A CFH IL6 CXCR3 C3
7 vision/eye MP:0005391 9.1 C3 IFNG IL4 CFH IL6 CTGF

Drugs & Therapeutics for Proliferative Glomerulonephritis

Drugs for Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 2, Phase 3 332348-12-6 10237
2
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
3
Mycophenolic acid Approved Phase 2, Phase 3 24280-93-1 446541
4
Mycophenolate mofetil Approved, Investigational Phase 2, Phase 3 128794-94-5 5281078
5
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
6
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
7 Prednisolone acetate Phase 2, Phase 3
8 glucocorticoids Phase 2, Phase 3
9 Methylprednisolone acetate Phase 2, Phase 3
10 Methylprednisolone Hemisuccinate Phase 2, Phase 3
11 Hormone Antagonists Phase 2, Phase 3
12 Hormones Phase 2, Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
14 Anti-Bacterial Agents Phase 2, Phase 3
15 Antibiotics, Antitubercular Phase 2, Phase 3
16 Pharmaceutical Solutions Phase 2, Phase 3
17 Immunosuppressive Agents Phase 2, Phase 3
18 Prednisolone hemisuccinate Phase 2, Phase 3
19 Prednisolone phosphate Phase 2, Phase 3
20 Anti-Infective Agents Phase 2, Phase 3
21 Anti-Inflammatory Agents Phase 2, Phase 3
22 Antitubercular Agents Phase 2, Phase 3
23 Antirheumatic Agents Phase 2, Phase 3
24 Antineoplastic Agents, Hormonal Phase 2, Phase 3
25
Daratumumab Approved Phase 2 945721-28-8
26 Antibodies Phase 2
27 Immunoglobulins Phase 2
28 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis Terminated NCT00430677 Phase 2, Phase 3 Corticosteroids (prednisone or prednisolone);Abatacept;Abatacept;Mycophenolate mofetil (MMF);Abatacept
2 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

Anatomical Context for Proliferative Glomerulonephritis

MalaCards organs/tissues related to Proliferative Glomerulonephritis:

41
Kidney, Endothelial, T Cells, B Cells, Monocytes, Neutrophil, Prostate

Publications for Proliferative Glomerulonephritis

Articles related to Proliferative Glomerulonephritis:

(show top 50) (show all 415)
# Title Authors Year
1
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. ( 29782856 )
2018
2
Bilateral Diffuse and Cluster Pigment Epithelial Detachment Associated with Diffuse Proliferative Glomerulonephritis. ( 29675279 )
2018
3
Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress. ( 29607219 )
2018
4
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Lambda Deposits: Report of the First Pediatric Case. ( 29850460 )
2018
5
IgA-dominant extracapillary proliferative glomerulonephritis following Escherichia coli sepsis in a renal transplant recipient. ( 29809306 )
2018
6
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults. ( 29616329 )
2018
7
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft. ( 29716794 )
2018
8
A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits or de novo C3 glomerulonephritis after kidney transplantation. ( 29968411 )
2018
9
Proliferative glomerulonephritis with linear immunoglobulin deposition: is this atypical antiglomerular basement membrane disease? ( 29724870 )
2018
10
A clone-directed approach may improve diagnosis and treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits. ( 29759418 )
2018
11
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits of lambda chains. ( 29706814 )
2018
12
Successful treatment with steroid and cyclosporine A in a patient with immunoglobulin A-proliferative glomerulonephritis with monoclonal immunoglobulin deposits. ( 29577510 )
2018
13
Kimura's Disease Presenting as Proliferative Glomerulonephritis with Complete Heart Block. ( 29962683 )
2018
14
Monoclonal immunoglobulin-associated proliferative glomerulonephritis characterized by organized deposits of striated ultra-substructures: A case report. ( 28628381 )
2017
15
A case report of proliferative glomerulonephritis with monoclonal immunoglobulin M-kappa deposits without associated lymphoproliferative disorder or detectable paraproteinemia. ( 29230710 )
2017
16
Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report. ( 28385149 )
2017
17
Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change? ( 28621006 )
2017
18
Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation. ( 28381748 )
2017
19
Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis. ( 29348949 )
2017
20
Proliferative glomerulonephritis with monoclonal IgG deposits in two kidney allografts successfully treated with rituximab. ( 28616219 )
2017
21
Urinalysis in the Evaluation of Proliferative Glomerulonephritis. ( 28973230 )
2017
22
Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. ( 28810602 )
2017
23
Proliferative glomerulonephritis with monotypic IgA-kappa deposits in a 10-year-old. ( 28807265 )
2017
24
Proliferative Glomerulonephritis With Masked Monoclonal Deposits Responsive to Myeloma Therapy. ( 29270532 )
2017
25
A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features. ( 29209544 )
2017
26
Proliferative glomerulonephritis with monoclonal IgG deposits; an unusual cause of de novo disease in kidney allograft. ( 28975104 )
2017
27
Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene. ( 28566604 )
2017
28
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
29
Th1, Th2 and Treg/T17 cytokines in two types of proliferative glomerulonephritis. ( 27194829 )
2016
30
AJKD Atlas of Renal Pathology: Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits. ( 26916379 )
2016
31
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits complicated by immunoglobulin A nephropathy in the renal allograft. ( 26971743 )
2016
32
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
33
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
34
De Novo Proliferative Glomerulonephritis with Monoclonal IgG Deposits of the IgG1I_ Subtype in a Kidney Allograft. ( 26976360 )
2016
35
Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft. ( 26997395 )
2016
36
Immune Complex-Mediated Proliferative Glomerulonephritis Induced by Paclitaxel Treatment. ( 27845869 )
2016
37
Proliferative Glomerulonephritis With Monoclonal IgG1I_ Deposits in a Hepatitis C Virus-Positive Patient. ( 26612277 )
2016
38
Significance of CD163-Positive Macrophages in Proliferative Glomerulonephritis. ( 26379042 )
2015
39
Post-Legionellosis Proliferative Glomerulonephritis. ( 26648502 )
2015
40
Hydrogen peroxide-inducible clone-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. ( 25835392 )
2015
41
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
42
Hepatitis C virus-related mixed cryoglobulinemic endocapillary proliferative glomerulonephritis and B-cell non-Hodgkin lymphoma: a case report and literature review. ( 26367728 )
2015
43
Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts. ( 26613031 )
2015
44
Diffuse mesangial and endocapillary cell proliferative glomerulonephritis with persistent hypocomplementemia in a child. ( 26629229 )
2015
45
Glomerular Damage in Experimental Proliferative Glomerulonephritis Under Glomerular Capillary Hypertension. ( 25871528 )
2015
46
Correlation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression. ( 25715120 )
2015
47
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. ( 25932265 )
2015
48
A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain. ( 25410550 )
2015
49
Proliferative glomerulonephritis with monoclonal immunoglobulin deposition disease: The utility of routine staining with immunoglobulin light chains. ( 26664209 )
2015
50
Recurrent Proliferative Glomerulonephritis With Monoclonal IgG Deposits After a Renal Transplant Which Was Insensitive to Pulse Therapy Remitted by Double Filtration Plasmapheresis. ( 25275829 )
2014

Variations for Proliferative Glomerulonephritis

Expression for Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for Proliferative Glomerulonephritis

Pathways related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 C3 CCL2 CD79A CFH CR1 IFNG
2
Show member pathways
13.1 CCL2 CTGF CXCR3 IL4 IL6
3
Show member pathways
12.56 C3 CCL2 IFNG IL4 IL6
4 12.4 CCL2 CD79A IFNG IL4
5
Show member pathways
12.16 CCL2 IFNG IL4 IL6
6
Show member pathways
12.14 CCL2 IFNG IL4 IL6
7
Show member pathways
12.03 C3 CR1 IFNG IL4
8
Show member pathways
12.02 IFNG IL4 IL6
9 11.99 C3 CR1 IFNG IL6
10
Show member pathways
11.96 C3 CFH CR1
11 11.94 C3 CFH CR1
12
Show member pathways
11.91 C3 CFH CR1
13 11.84 CCL2 IL4 IL6
14
Show member pathways
11.81 CCL2 CTGF IFNG IL4 IL6
15
Show member pathways
11.8 C3 CFH CR1
16 11.75 CR1 IL4 IL6
17 11.71 CCL2 IFNG IL6
18 11.66 IFNG IL4 IL6
19 11.64 CXCR3 IFNG IL4
20 11.64 CCL2 IFNG IL4 IL6
21 11.52 CD79A IFNG IL4 IL6
22 11.45 C3 CR1 IL6
23 11.36 CCL2 IL4 IL6
24 11.17 IFNG IL4
25 11.06 CCL2 CTGF IL4 IL6
26 11.05 IFNG IL4
27 11.05 IFNG IL4 IL6
28 11.03 CCL2 IFNG
29 10.97 IFNG IL4 IL6
30 10.61 CCL2 CR1 IFNG IL6

GO Terms for Proliferative Glomerulonephritis

Cellular components related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 C3 CCL2 CFH CTGF IFNG IL4
2 extracellular region GO:0005576 9.23 C3 CCL2 CFH CTGF IFNG IL4

Biological processes related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.67 CCL2 CD79A CXCR3 IFNG
2 positive regulation of protein phosphorylation GO:0001934 9.65 C3 CTGF IFNG
3 regulation of complement activation GO:0030449 9.61 C3 CFH CR1
4 immune response GO:0006955 9.55 C3 CCL2 IFNG IL4 IL6
5 B cell activation GO:0042113 9.49 CD79A IL4
6 regulation of regulatory T cell differentiation GO:0045589 9.46 CR1 IFNG
7 humoral immune response GO:0006959 9.43 CCL2 IFNG IL6
8 complement activation, alternative pathway GO:0006957 9.4 C3 CFH
9 regulation of signaling receptor activity GO:0010469 9.35 CCL2 CTGF IFNG IL4 IL6
10 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 CCL2
11 inflammatory response GO:0006954 9.02 C3 CCL2 CXCR3 IL6 SIGLEC1

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 CTGF IL4 IL6
2 cytokine activity GO:0005125 8.92 CCL2 IFNG IL4 IL6

Sources for Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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