MCID: PRL003
MIFTS: 45

Proliferative Glomerulonephritis

Categories: Nephrological diseases

Aliases & Classifications for Proliferative Glomerulonephritis

MalaCards integrated aliases for Proliferative Glomerulonephritis:

Name: Proliferative Glomerulonephritis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4778
NCIt 50 C35281
UMLS 73 C0235618

Summaries for Proliferative Glomerulonephritis

MalaCards based summary : Proliferative Glomerulonephritis is related to mesangial proliferative glomerulonephritis and acute proliferative glomerulonephritis. An important gene associated with Proliferative Glomerulonephritis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Mycophenolic acid and Abatacept have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Proliferative Glomerulonephritis

Diseases in the Proliferative Glomerulonephritis family:

Acute Proliferative Glomerulonephritis

Diseases related to Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 mesangial proliferative glomerulonephritis 34.1 CCL2 CD79A IL6
2 acute proliferative glomerulonephritis 34.0 CCL2 MPO
3 glomerulonephritis 30.9 C3 CCL2 CD79A CFH CR1 MPO
4 iga glomerulonephritis 30.3 CCL2 CD79A IL6
5 cryoglobulinemia 30.1 CD79A CXCL10 CXCR3
6 membranoproliferative glomerulonephritis 30.0 C3 CD79A CFH
7 rheumatoid arthritis 29.8 CCL2 IFNG IL4 IL6
8 viral infectious disease 29.7 CXCL10 IFNG IL4 IL6
9 q fever 29.7 IFNG IL4 IL6
10 kidney disease 29.6 C3 CCL2 CFH IL6
11 psoriasis 29.0 CCL2 CXCL10 CXCR3 IFNG IL4 IL6
12 pulmonary disease, chronic obstructive 29.0 CCL2 CXCL10 CXCR3 IL6 MPO
13 malaria 28.7 CCL2 CR1 CXCL10 CXCR3 IFNG IL4
14 systemic lupus erythematosus 28.3 C3 CCL2 CD79A CFH CR1 CXCL10
15 c1q deficiency 11.2
16 focal segmental glomerulosclerosis 4 10.4
17 nephrotic syndrome, type 6 10.4
18 focal segmental glomerulosclerosis 10.4
19 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.4
20 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 10.4
21 nephrotic syndrome 10.4
22 hepatitis 10.2
23 lupus erythematosus 10.2
24 dense deposit disease 10.2 C3 CFH
25 retinal drusen 10.2 C3 CFH
26 histoplasmosis 10.2 C3 IFNG
27 t-cell/histiocyte rich large b cell lymphoma 10.2 CR1 IFNG
28 complement factor i deficiency 10.2 C3 CR1
29 enterocolitis 10.2 C3 CFH
30 diabetic foot ulcers 10.2 CCL2 IL6
31 chronic eosinophilic pneumonia 10.2 CCL2 CXCR3
32 denture stomatitis 10.2 CCL2 IL6
33 hyperlucent lung 10.2 IFNG IL4
34 autoimmune myocarditis 10.2 IFNG IL4
35 arteriolosclerosis 10.2 C3 CD79A
36 sporotrichosis 10.2 CD79A IFNG
37 nickel allergic contact dermatitis 10.2 IFNG IL4
38 baylisascariasis 10.2 IFNG IL4
39 penicillin allergy 10.2 IFNG IL4
40 meconium aspiration syndrome 10.2 IFNG IL6
41 hepatitis c virus 10.2
42 hepatitis c 10.2
43 relapsing polychondritis 10.2 IFNG IL6
44 central nervous system vasculitis 10.2 IFNG IL6
45 atopic keratoconjunctivitis 10.2 IFNG IL4
46 crustacean allergy 10.2 IFNG IL4
47 chronic graft versus host disease 10.2 CD79A IFNG
48 anterior uveitis 10.1 CFH IL6
49 strongyloidiasis 10.1 CD79A IFNG
50 degeneration of macula and posterior pole 10.1 C3 CCL2 CFH

Graphical network of the top 20 diseases related to Proliferative Glomerulonephritis:



Diseases related to Proliferative Glomerulonephritis

Symptoms & Phenotypes for Proliferative Glomerulonephritis

GenomeRNAi Phenotypes related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.6 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.6 IL4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 CD79A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.6 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.6 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.6 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.6 CD79A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.6 IL4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.6 MPO
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.6 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.6 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 IL4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.6 MPO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.6 CD79A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.6 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 CD79A IL4 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.6 CD79A

MGI Mouse Phenotypes related to Proliferative Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 C3 CD79A CFH CXCL10 CXCR3 IFNG
2 cardiovascular system MP:0005385 9.87 C3 CFH CXCL10 CXCR3 IFNG IL6
3 homeostasis/metabolism MP:0005376 9.85 C3 CD79A CFH CXCL10 CXCR3 IFNG
4 immune system MP:0005387 9.7 C3 CCL2 CD79A CFH CXCL10 CXCR3
5 renal/urinary system MP:0005367 9.17 C3 CD79A CFH CXCR3 IFNG IL4

Drugs & Therapeutics for Proliferative Glomerulonephritis

Drugs for Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 2, Phase 3 24280-93-1 446541
2
Abatacept Approved Phase 2, Phase 3 332348-12-6 10237
3
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
6
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
7
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
8
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
9 Immunologic Factors Phase 2, Phase 3
10 Antirheumatic Agents Phase 2, Phase 3
11 Antineoplastic Agents, Hormonal Phase 2, Phase 3
12 Antitubercular Agents Phase 2, Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
14 Prednisolone acetate Phase 2, Phase 3
15 Pharmaceutical Solutions Phase 2, Phase 3
16 Immunosuppressive Agents Phase 2, Phase 3
17 Antibiotics, Antitubercular Phase 2, Phase 3
18 Methylprednisolone acetate Phase 2, Phase 3
19 Hormone Antagonists Phase 2, Phase 3
20 Anti-Inflammatory Agents Phase 2, Phase 3
21 Hormones Phase 2, Phase 3
22 Anti-Infective Agents Phase 2, Phase 3
23 glucocorticoids Phase 2, Phase 3
24 Anti-Bacterial Agents Phase 2, Phase 3
25
Daratumumab Approved Phase 2 945721-28-8
26 Antibodies, Monoclonal Phase 2
27 Antibodies Phase 2
28 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis Terminated NCT00430677 Phase 2, Phase 3 Corticosteroids (prednisone or prednisolone);Abatacept;Abatacept;Mycophenolate mofetil (MMF);Abatacept
2 Daratumumab in Treatment of PGNMID and C3 GN Recruiting NCT03095118 Phase 2 Daratumumab

Search NIH Clinical Center for Proliferative Glomerulonephritis

Genetic Tests for Proliferative Glomerulonephritis

Anatomical Context for Proliferative Glomerulonephritis

MalaCards organs/tissues related to Proliferative Glomerulonephritis:

41
Kidney, T Cells, B Cells, Lung, Bone, Heart, Monocytes

Publications for Proliferative Glomerulonephritis

Articles related to Proliferative Glomerulonephritis:

(show top 50) (show all 430)
# Title Authors Year
1
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. ( 29782856 )
2018
2
Bilateral Diffuse and Cluster Pigment Epithelial Detachment Associated with Diffuse Proliferative Glomerulonephritis. ( 29675279 )
2018
3
Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress. ( 29607219 )
2018
4
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Lambda Deposits: Report of the First Pediatric Case. ( 29850460 )
2018
5
IgA-dominant extracapillary proliferative glomerulonephritis following Escherichia coli sepsis in a renal transplant recipient. ( 29809306 )
2018
6
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults. ( 29616329 )
2018
7
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft. ( 29716794 )
2018
8
A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits or de novo C3 glomerulonephritis after kidney transplantation. ( 29968411 )
2018
9
Proliferative glomerulonephritis with linear immunoglobulin deposition: is this atypical antiglomerular basement membrane disease? ( 29724870 )
2018
10
A clone-directed approach may improve diagnosis and treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposits. ( 29759418 )
2018
11
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits of lambda chains. ( 29706814 )
2018
12
Successful treatment with steroid and cyclosporine A in a patient with immunoglobulin A-proliferative glomerulonephritis with monoclonal immunoglobulin deposits. ( 29577510 )
2018
13
Bartonella Infectious Endocarditis Associated With Cryoglobulinemia and Multifocal Proliferative Glomerulonephritis. ( 30151411 )
2018
14
A Case of Switch from C3 Glomerulonephritis to Proliferative Glomerulonephritis with Monoclonal IgG Deposits. ( 30143498 )
2018
15
Suppressor of Cytokine Signaling-1/STAT1 Regulates Renal Inflammation in Mesangial Proliferative Glomerulonephritis Models. ( 30214448 )
2018
16
Kimura's Disease Presenting as Proliferative Glomerulonephritis with Complete Heart Block. ( 29962683 )
2018
17
Proliferative glomerulonephritis with unusual microlamellar organized deposits related to monoclonal immunoglobulin G3 (IgG3) kappa. ( 29987665 )
2018
18
Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts. ( 29996809 )
2018
19
Monoclonal immunoglobulin-associated proliferative glomerulonephritis characterized by organized deposits of striated ultra-substructures: A case report. ( 28628381 )
2017
20
A case report of proliferative glomerulonephritis with monoclonal immunoglobulin M-kappa deposits without associated lymphoproliferative disorder or detectable paraproteinemia. ( 29230710 )
2017
21
Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case report. ( 28385149 )
2017
22
Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change? ( 28621006 )
2017
23
Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation. ( 28381748 )
2017
24
Cetuximab-Associated Crescentic Diffuse Proliferative Glomerulonephritis. ( 29348949 )
2017
25
Proliferative glomerulonephritis with monoclonal IgG deposits in two kidney allografts successfully treated with rituximab. ( 28616219 )
2017
26
Urinalysis in the Evaluation of Proliferative Glomerulonephritis. ( 28973230 )
2017
27
Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. ( 28810602 )
2017
28
Proliferative glomerulonephritis with monotypic IgA-kappa deposits in a 10-year-old. ( 28807265 )
2017
29
Proliferative Glomerulonephritis With Masked Monoclonal Deposits Responsive to Myeloma Therapy. ( 29270532 )
2017
30
A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features. ( 29209544 )
2017
31
Proliferative glomerulonephritis with monoclonal IgG deposits; an unusual cause of de novo disease in kidney allograft. ( 28975104 )
2017
32
Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene. ( 28566604 )
2017
33
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
34
Th1, Th2 and Treg/T17 cytokines in two types of proliferative glomerulonephritis. ( 27194829 )
2016
35
AJKD Atlas of Renal Pathology: Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits. ( 26916379 )
2016
36
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits complicated by immunoglobulin A nephropathy in the renal allograft. ( 26971743 )
2016
37
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
38
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
39
De Novo Proliferative Glomerulonephritis with Monoclonal IgG Deposits of the IgG1I_ Subtype in a Kidney Allograft. ( 26976360 )
2016
40
Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft. ( 26997395 )
2016
41
Immune Complex-Mediated Proliferative Glomerulonephritis Induced by Paclitaxel Treatment. ( 27845869 )
2016
42
Proliferative Glomerulonephritis With Monoclonal IgG1I_ Deposits in a Hepatitis C Virus-Positive Patient. ( 26612277 )
2016
43
Significance of CD163-Positive Macrophages in Proliferative Glomerulonephritis. ( 26379042 )
2015
44
Post-Legionellosis Proliferative Glomerulonephritis. ( 26648502 )
2015
45
Hydrogen peroxide-inducible clone-5 regulates mesangial cell proliferation in proliferative glomerulonephritis in mice. ( 25835392 )
2015
46
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
47
Hepatitis C virus-related mixed cryoglobulinemic endocapillary proliferative glomerulonephritis and B-cell non-Hodgkin lymphoma: a case report and literature review. ( 26367728 )
2015
48
Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts. ( 26613031 )
2015
49
Diffuse mesangial and endocapillary cell proliferative glomerulonephritis with persistent hypocomplementemia in a child. ( 26629229 )
2015
50
Glomerular Damage in Experimental Proliferative Glomerulonephritis Under Glomerular Capillary Hypertension. ( 25871528 )
2015

Variations for Proliferative Glomerulonephritis

Expression for Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Proliferative Glomerulonephritis.

Pathways for Proliferative Glomerulonephritis

Pathways related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 C3 CCL2 CD79A CFH CR1 CXCL10
2
Show member pathways
12.85 C3 CCL2 CXCL10 IFNG IL6
3
Show member pathways
12.64 C3 CCL2 CXCL10 IFNG IL4 IL6
4
Show member pathways
12.45 CCL2 IFNG IL6 MPO
5 12.25 CCL2 CD79A CXCL10 IFNG IL4 MPO
6
Show member pathways
12.19 CCL2 IFNG IL4 IL6 MPO
7
Show member pathways
12.16 CCL2 CXCL10 IFNG IL4 IL6
8
Show member pathways
12.13 C3 CR1 IFNG IL4
9 12.09 C3 CR1 IFNG IL6
10
Show member pathways
12.04 CXCL10 IFNG IL4 IL6
11
Show member pathways
12 C3 CFH CR1
12 11.98 C3 CFH CR1
13
Show member pathways
11.96 C3 CFH CR1
14
Show member pathways
11.95 CCL2 IFNG IL4 IL6
15
Show member pathways
11.92 IFNG IL4 IL6
16
Show member pathways
11.88 CCL2 CXCL10 CXCR3
17 11.87 CCL2 IL4 IL6
18 11.85 CCL2 CXCL10 IL6
19
Show member pathways
11.82 C3 CFH CR1
20 11.77 CR1 IL4 IL6
21 11.73 CCL2 IFNG IL6
22 11.68 IFNG IL4 IL6
23 11.66 CXCR3 IFNG IL4
24 11.63 CCL2 CXCL10 IFNG IL4 IL6
25 11.55 CCL2 IL4 IL6
26 11.48 C3 CR1 IL6
27 11.42 CD79A IFNG IL4 IL6 MPO
28 11.36 CCL2 CXCL10 IL4 IL6
29 11.31 CCL2 CR1 IFNG IL6
30 11.19 IFNG IL4 IL6
31 11.13 IFNG IL4 IL6
32 11.08 IFNG IL4
33 11.08 CCL2 CXCL10 IL4 IL6
34 11.06 CCL2 IFNG
35 10.88 CCL2 CXCL10 IL4 IL6
36 10.87 CCL2 CXCL10 IFNG IL4 IL6
37 10.85 CCL2 MPO

GO Terms for Proliferative Glomerulonephritis

Cellular components related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 C3 CCL2 CFH CXCL10 IFNG IL4
2 extracellular region GO:0005576 9.28 C3 CCL2 CFH CXCL10 IFNG IL4

Biological processes related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 CCL2 CXCL10 IL4 IL6
2 defense response to virus GO:0051607 9.75 CXCL10 IFNG IL6
3 cellular response to lipopolysaccharide GO:0071222 9.74 CCL2 CXCL10 IL6
4 chemotaxis GO:0006935 9.73 CCL2 CXCL10 CXCR3
5 regulation of complement activation GO:0030449 9.71 C3 CFH CR1
6 response to bacterium GO:0009617 9.7 C3 CCL2 CXCL10
7 cell chemotaxis GO:0060326 9.65 CCL2 CXCL10 CXCR3
8 regulation of signaling receptor activity GO:0010469 9.65 CCL2 CXCL10 IFNG IL4 IL6
9 chemokine-mediated signaling pathway GO:0070098 9.61 CCL2 CXCL10 CXCR3
10 B cell activation GO:0042113 9.58 CD79A IL4
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNG IL4 IL6
12 regulation of regulatory T cell differentiation GO:0045589 9.55 CR1 IFNG
13 cell surface receptor signaling pathway GO:0007166 9.55 CCL2 CD79A CXCL10 CXCR3 IFNG
14 complement activation, alternative pathway GO:0006957 9.51 C3 CFH
15 humoral immune response GO:0006959 9.5 CCL2 IFNG IL6
16 T cell chemotaxis GO:0010818 9.49 CXCL10 CXCR3
17 inflammatory response GO:0006954 9.43 C3 CCL2 CXCL10 CXCR3 IL6 SIGLEC1
18 positive regulation of apoptotic cell clearance GO:2000427 9.37 C3 CCL2
19 immune response GO:0006955 9.17 C3 CCL2 CXCL10 CXCR3 IFNG IL4

Molecular functions related to Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.13 CFH CXCL10 MPO
2 cytokine activity GO:0005125 9.02 CCL2 CXCL10 IFNG IL4 IL6

Sources for Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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